CA2220026C - Dentifrice compositions - Google Patents
Dentifrice compositions Download PDFInfo
- Publication number
- CA2220026C CA2220026C CA002220026A CA2220026A CA2220026C CA 2220026 C CA2220026 C CA 2220026C CA 002220026 A CA002220026 A CA 002220026A CA 2220026 A CA2220026 A CA 2220026A CA 2220026 C CA2220026 C CA 2220026C
- Authority
- CA
- Canada
- Prior art keywords
- abrasive
- ratio
- particles
- sodium
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 82
- 239000000551 dentifrice Substances 0.000 title claims description 29
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 101
- 239000002245 particle Substances 0.000 claims abstract description 39
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 39
- 238000005299 abrasion Methods 0.000 claims abstract description 29
- 238000004140 cleaning Methods 0.000 claims abstract description 29
- 230000002285 radioactive effect Effects 0.000 claims abstract description 24
- 210000004268 dentin Anatomy 0.000 claims abstract description 21
- 238000010521 absorption reaction Methods 0.000 claims abstract description 17
- 239000000606 toothpaste Substances 0.000 claims abstract description 13
- 229910001369 Brass Inorganic materials 0.000 claims abstract description 9
- 239000010951 brass Substances 0.000 claims abstract description 9
- 229920000728 polyester Polymers 0.000 claims abstract description 9
- 239000004094 surface-active agent Substances 0.000 claims description 17
- -1 alkali metal citrates Chemical class 0.000 claims description 16
- 239000002738 chelating agent Substances 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 10
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 9
- 229910052783 alkali metal Inorganic materials 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 229940071089 sarcosinate Drugs 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229940034610 toothpaste Drugs 0.000 claims description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- 210000003298 dental enamel Anatomy 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 239000011775 sodium fluoride Substances 0.000 claims description 5
- 235000013024 sodium fluoride Nutrition 0.000 claims description 5
- 229960000414 sodium fluoride Drugs 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- 239000003906 humectant Substances 0.000 claims description 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 4
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 4
- 108700004121 sarkosyl Proteins 0.000 claims description 4
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 claims description 4
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 4
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 4
- 239000001433 sodium tartrate Substances 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 239000007937 lozenge Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 229960002167 sodium tartrate Drugs 0.000 claims description 3
- 235000011004 sodium tartrates Nutrition 0.000 claims description 3
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 3
- 229960002799 stannous fluoride Drugs 0.000 claims description 3
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims description 2
- 239000006072 paste Substances 0.000 claims description 2
- 239000011698 potassium fluoride Substances 0.000 claims description 2
- 235000003270 potassium fluoride Nutrition 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 2
- 229940104261 taurate Drugs 0.000 claims description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 2
- 108010077895 Sarcosine Proteins 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229940041672 oral gel Drugs 0.000 claims 1
- AUHKUMFBHOJIMU-UHFFFAOYSA-M sodium;2-[hexadecanoyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCCCCC(=O)N(C)CC([O-])=O AUHKUMFBHOJIMU-UHFFFAOYSA-M 0.000 claims 1
- VLKIFCBXANYYCK-GMFCBQQYSA-M sodium;2-[methyl-[(z)-octadec-9-enoyl]amino]acetate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC(=O)N(C)CC([O-])=O VLKIFCBXANYYCK-GMFCBQQYSA-M 0.000 claims 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract description 19
- 239000003921 oil Substances 0.000 description 15
- 239000000306 component Substances 0.000 description 14
- 229940123150 Chelating agent Drugs 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000000796 flavoring agent Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 7
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- 229940091249 fluoride supplement Drugs 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 229920001577 copolymer Polymers 0.000 description 5
- 235000011180 diphosphates Nutrition 0.000 description 5
- 235000013355 food flavoring agent Nutrition 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 description 4
- 239000003093 cationic surfactant Substances 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 239000001488 sodium phosphate Substances 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 150000001340 alkali metals Chemical class 0.000 description 3
- 150000008064 anhydrides Chemical class 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229920005646 polycarboxylate Polymers 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 2
- TYIOVYZMKITKRO-UHFFFAOYSA-N 2-[hexadecyl(dimethyl)azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)CC([O-])=O TYIOVYZMKITKRO-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000003082 abrasive agent Substances 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 229910052910 alkali metal silicate Inorganic materials 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 2
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 2
- 238000007429 general method Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 229940075468 lauramidopropyl betaine Drugs 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229960003975 potassium Drugs 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 2
- 235000019801 trisodium phosphate Nutrition 0.000 description 2
- CKUJRAYMVVJDMG-IYEMJOQQSA-L (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;tin(2+) Chemical compound [Sn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O CKUJRAYMVVJDMG-IYEMJOQQSA-L 0.000 description 1
- OZCMOJQQLBXBKI-UHFFFAOYSA-N 1-ethenoxy-2-methylpropane Chemical compound CC(C)COC=C OZCMOJQQLBXBKI-UHFFFAOYSA-N 0.000 description 1
- IYSIFQMHXXJRHX-UHFFFAOYSA-M 1-ethyl-2-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCC1=CC=CC=[N+]1CC IYSIFQMHXXJRHX-UHFFFAOYSA-M 0.000 description 1
- BMVLUGUCGASAAK-UHFFFAOYSA-M 1-hexadecylpyridin-1-ium;fluoride Chemical compound [F-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 BMVLUGUCGASAAK-UHFFFAOYSA-M 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- GEZAUFNYMZVOFV-UHFFFAOYSA-J 2-[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetan-2-yl)oxy]-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetane 2-oxide Chemical compound [Sn+2].[Sn+2].[O-]P([O-])(=O)OP([O-])([O-])=O GEZAUFNYMZVOFV-UHFFFAOYSA-J 0.000 description 1
- NPKLJZUIYWRNMV-UHFFFAOYSA-N 2-[decyl(dimethyl)azaniumyl]acetate Chemical compound CCCCCCCCCC[N+](C)(C)CC([O-])=O NPKLJZUIYWRNMV-UHFFFAOYSA-N 0.000 description 1
- HVYJSOSGTDINLW-UHFFFAOYSA-N 2-[dimethyl(octadecyl)azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CC([O-])=O HVYJSOSGTDINLW-UHFFFAOYSA-N 0.000 description 1
- KKMIHKCGXQMFEU-UHFFFAOYSA-N 2-[dimethyl(tetradecyl)azaniumyl]acetate Chemical compound CCCCCCCCCCCCCC[N+](C)(C)CC([O-])=O KKMIHKCGXQMFEU-UHFFFAOYSA-N 0.000 description 1
- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 101100313763 Arabidopsis thaliana TIM22-2 gene Proteins 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
- 108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 241001340526 Chrysoclista linneella Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 1
- 244000024873 Mentha crispa Species 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 244000227633 Ocotea pretiosa Species 0.000 description 1
- 235000004263 Ocotea pretiosa Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 208000008617 Tooth Demineralization Diseases 0.000 description 1
- 206010072665 Tooth demineralisation Diseases 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 description 1
- 229960005164 acesulfame Drugs 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- BAPJBEWLBFYGME-UHFFFAOYSA-N acrylic acid methyl ester Natural products COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000004964 aerogel Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- VVYPIVJZLVJPGU-UHFFFAOYSA-L copper;2-aminoacetate Chemical compound [Cu+2].NCC([O-])=O.NCC([O-])=O VVYPIVJZLVJPGU-UHFFFAOYSA-L 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000016693 dipotassium tartrate Nutrition 0.000 description 1
- 235000019524 disodium tartrate Nutrition 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 235000010985 glycerol esters of wood rosin Nutrition 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 229940071145 lauroyl sarcosinate Drugs 0.000 description 1
- 229940094506 lauryl betaine Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- BSDKWFAJZDUHKQ-UHFFFAOYSA-N methoxyethene Chemical compound COC=C.COC=C BSDKWFAJZDUHKQ-UHFFFAOYSA-N 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 235000019960 monoglycerides of fatty acid Nutrition 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 235000016337 monopotassium tartrate Nutrition 0.000 description 1
- 229940070782 myristoyl sarcosinate Drugs 0.000 description 1
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical group [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001444 polymaleic acid Polymers 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 229940086065 potassium hydrogentartrate Drugs 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 description 1
- 239000001472 potassium tartrate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Inorganic materials [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 1
- 239000001476 sodium potassium tartrate Substances 0.000 description 1
- 235000011006 sodium potassium tartrate Nutrition 0.000 description 1
- NKAAEMMYHLFEFN-ZVGUSBNCSA-M sodium;(2r,3r)-2,3,4-trihydroxy-4-oxobutanoate Chemical compound [Na+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O NKAAEMMYHLFEFN-ZVGUSBNCSA-M 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- DIORMHZUUKOISG-UHFFFAOYSA-N sulfoformic acid Chemical compound OC(=O)S(O)(=O)=O DIORMHZUUKOISG-UHFFFAOYSA-N 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/113—Silicon oxides; Hydrates thereof
- C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
- C01B33/18—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
- C01B33/187—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof by acidic treatment of silicates
- C01B33/193—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof by acidic treatment of silicates of aqueous solutions of silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/02—Amorphous compounds
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/61—Micrometer sized, i.e. from 1-100 micrometer
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/19—Oil-absorption capacity, e.g. DBP values
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/90—Other properties not specified above
Abstract
Oral compositions, such as oral gels and toothpastes, containing a novel abrasive. An amorphous silica abrasive composition, comprising: a) a precipitated silica, comprising particles wherein said particles have: i) a mean particle size of from 5 to 11 microns (s.d. < 9); ii) an Einlehner hardness of from 0.8 to 2.5 for abrasive to brass screen and from 5 to 8 for abrasive to polyester screen; iii) an oil absorption of from 95 ml/100 gm to 135 ml/100 gm; and iv) a radioactive dentin abrasion of from 25 to 90; and b ) a gel silica, comprising particles wherein said particles have: i) a mean particle size of from 5 to 11 microns (s.d. < 9); ii) an Einlehner hardne ss of from 3 to 15 for abrasive to brass screen and from 8 to 20 for abrasive to polyester screen; iii) an oil absorption of from 60 ml/100 gm to 130 ml/100 gm; and iv) a radioactive dentin abrasion of from 80 to 200 wherein at least 70 % of all of said particles have a diameter of below 25 microns and wherei n the pellicle cleaning ratio is from 90 to 135, preferably from 110 to 135, a nd the radioactive dentin abrasion is from 60 to 100, preferably from 65 to 85, with a pellicle cleaning ratio/radioactive dentin abrasion ratio of from 1.2 0 to 1.60, preferably 1.25 to 1.50, and wherein the ratio of precipitated sili ca to gel silica isfrom 90:10 to 60:40, preferably 80:20 to 60:40, respectively .
Description
DENTIFRICE COMPOSITIONS
TECHNICAL FIELD
This invention relates to dentifrice compositions such as toothpastes which ' provide improved oral cleaning.
BACKGROUND OF THE INVENTION
Synthetically produced amorphous silicas play an important role as an ingredient in many of today's toothpaste formulations. In addition to their cleaning albility, they are also relatively safe, nontoxic, and compatible with other toothpaste ingredients, including glycerin, sorbitol (or xylitol), thickening agents, detergents coloring and fragrance materials and, optionally, fluoride containing compositions.
Synthetic precipitated silicas are prepared by admixing dilute alkali silicate solutions with strong aqueous mineral acids under conditions where aggregation to the sol and gel cannot occur, stirring and then filtering out the precipitated silica.
The resulting precipitate is next washed, dried and comminuted to desired size.
Silica gels include silica hydrogels, hydrous gels, aerogels, and xerogels.
Silica gels are also formed by reacting alkali silicate solutions with strong acids to form a hydrosol and aging the newly formed hydrosol to form the hydrogel. The hydrogel is then washed, dried and comminuted as described above.
When preparing synthetic silicas, the objective is to obtain silicas which provide maximal cleaning with minimal damage to oral tissue. Dental researchers are continually concerned with identifying precipitated silicas meeting these objectives.
Examples of precipitated silicas described in the art include U.S. Patent 4 122.161 to Wason, October 24, 1978, U. S. Patents 4.992.251 and 5.03 S 879 to Aldcroft et al., February 12, 1991 and July 30, 1991 respectively, U.S. Patent 5 098_695 to Newton et al., March 24, 1992, and U.S. Patent 5.279.815 to Wason et al., January 18, 1994. Similarly, silica gels have also been described in the art as demonstrated by U.S. Patent 4,303,641. December 1, 1981, to DeWolf, II et al., U.S. Patent 4.153,680, May 8, 1979, to Seybert, and U.S. Patent 3.538.230, November 3, 1970, to Pader et al..
Moreover, various combinations of silicas have been described in the art.
Silica combinations involving compositions of differing particle sizes and specific surface areas are disclosed in U.S. Patent .3.577,521 to Karlheinz Scheller et al., May 4, 1971 and U.S. Patent 4.618.488 to Maeyama et al., October 21, 1986, respectively. Similarly, U.S. Patents 5.110.574 to Reinhardt et al., May 5, discloses combining precipitated thickener and polishing silicas to form silica compositions having oil absorption values of at least 200. Further examples of silica combinations include U.S. Patent 5.124.143 to Muhlemann, June 23, 1992 and U.S.
Patent 4.632.826 to Ploger et al., December 30, 1986.
While the prior art discloses a variety of silica compositions useful as dental °
cleaning abrasives, there is still a need for additional compositions providing improved cleaning with minimal abrasion. The present inventor has discovered °
amorphous silica abrasive compositions comprising precipitated and gel silicas providing improved dental cleaning with minimal abrasion.
Accordingly, it is the object of the present invention to provide a precipitated silica and gel silica compositions providing improved pellicle cleaning without a corresponding increase in dentin or enamel abrasion. Another object of the present invention is to provide an improved method for the prevention or removal tooth stains. A further object of the present invention is to provide an improved method for the prevention or removal of plaque. These and other objects will become readily apparent from the disclosure which follows.
SUMMARY OF THE INVENTION
The present invention relates to amorphous silica abrasive compositions, comprising:
a.) a precipitated silica, comprising particles wherein said particles have:
i.) a mean particle size of from about 5 to about 11 microns (s.d. < 9);
ii.) an Einlehner hardness of from about 0.8 to about 2.5 for abrasive to brass screen and from about 5 to about 8 for abrasive to polyester screen;
iii.) an oil absorption of from about 95 ml/100 gm to about 135 ml/100 gm; and iv.) a radioactive dentin abrasion of from about 25 to about 90;
and b.) a gel silica, comprising particles wherein said particles have:
i.) a mean particle size of from about 5 to about 11 °
microns (s.d. < 9);
ii.) an Einlehner hardness of from about 3 to about I 5 for abrasive to brass screen and from about 8 to about 20 for abrasive to polyester screen;
WO 961'34593 PCT/US96/45497 iii.) . an oil absorption of from about 60 ml/100 gm to about 130 ml/100 gm; and iv) a radioactive dentin abrasion of from about 80 to about 200 v~~herein at least about 70% of all of said particles have a diameter of below about 25 i rrucrons and wherein the pellicle cleaning ratio is from about 90 to about 135 and the radioactive dentin abrasion is from about 60 to about 100 with a pellicle cleaning ratio/radioactive dentin abrasion ratio of from about 1.20 to about 1.60 and wherein the ratio of precipitated silica to gel silica is from about 90:10 to about 60:40, respectively.
All levels and ratios are by weight of the total composition, unless otherwise indicated. Additionally, all measurements are made at 25C
unless otherwise specified.
The pH of the present herein described compositions range from about 4 to about 9.5, with the preferred pH being from about 6.5 to about 9.0 and the most preferred pH being 7.0 to about 8.5, as measured in a 5%
aqueous slurry.
DETAILED DESCRIPTION OF THE INVENTION
By "safe and effective amount," as used herein, means a suffcient amount to reduce stain and/or plaque/gingivitis without harming the tissues and structures of the oral cavity.
By the term "orally-acceptable carrier," as used herein, means a suitable vehicle which can be used to apply the present compositions to the oral cavity in a safe and effective manner.
The essential as well as optional components of the compositions of the present invention are described in the following paragraphs.
've The amorphous silicas used to form the precipitated silica and gel silica combinations of the present invention can be characterized as either Low Structure or Medium Structure silicas in accordance with the definitions set forth in the J. Soc.
Cosmet. Chem. 29., 497-521 (August, 1978), and Pigment Handbook:
Volume 1, Properties and Economics, Second Edition, Edited by Peter A. Lewis, John Wiley &
Sons, Inc., 1988, p. 139-159 and are preferably characterized as synthetic hydrated amorphous silicas, also known as silicon dioxides or Si02.
Further, these silicas may be characterized as having a BET surface area in the range of 50 to 250 m2/g. and as containing less than about 10%, more preferably less than about 5%, alumina.
The amorphous silica combinations of the present invention may be characterized as having a median average particle size ranging from about 5 microns to about 11 microns with at least 70% of the particle size distribution being less than 20 microns. The average particle size (mean value and median or 50%) is measured using a MicrotracTM II apparatus, Leeds and Northrup. Specifically, a laser beam is projected through a transparent cell, which contains a stream of moving particles suspended in a liquid. Light rays which strike the particles are scattered through angles which are inversely proportional to their sizes. The photodetector array measures the quantity of light at several predetermined angles. Electrical signals proportional to the measured light flux values are then processed by a microcomputer system to form a multi-channel histogram of the particle size distribution.
The amorphous precipitated and gel silicas used to form the combinatory compositions of the present invention are further characterized by means of their respective Einlehner hardness values, Radioactive Dentin Abrasion (RDA) values and oil absorption values.
Einlehner hardness values are measured using an Einlehner At-1000 Abrader to measure the softness of the silicas in the following manner: A Fourdrinier wire screen is weighed and exposed to the action of a 10% aqueous silica suspension for a certain length of time. The amount of abrasion is then determined as milligrams weight lost of the Fourdrinier wire screen per 100,000 revolutions. Brass Einlehner (BE) and Polyester Einlehner (PE) results are expressed in milligrams.
The RDA values are determined according to the method set forth by Hefferren, Journal of Dental Research, July-August 1976, pp. 563-573, and described in the Wason U.S. Patents 4_,,340,583, 4;420"312 and 4_,,421,527.
The amorphous silica combinations are, preferably, characterized as having oil absorption values less than 200 cc/ 100 gm. Oil absorption values are measured using the ASTM rub-out method D281. Surface area is determined by the BET
nitrogen adsorption method of Brunaur et al., J. Am. Chem. Soc., 60, 309 (1938). To measure brightness, fine powder materials that are pressed into a smooth surfaced pellet are evaluated using a Technidyne BrightimeterTM S-SBC. This instrument has a dual beam optical system where the sample is illuminated at an angle of 45°, and the reflected light viewed at 0°. It conforms to TAPPI test methods T452 and T646, and ASTM Standard D985. A series of filters direct to reflected light of desired wavelengths to a photocell where it is converted to an output voltage. This signal is amplified and then processed by an internal microcomputer for display and printout.
Precipitated silica suspensions are prepared in accordance with general methods described, for example, in prior U.S. Patents: 3. 893,840, issued July 8, 1975, to Wason; 3_.988,162, issued October 26, 1976, to Wason, 4.067,246, issued January 10, 1978, to Wason; and 4_,340,583, issued July 29, 1982, to Wason:
varying reaction parameters to form precipitated silicas having BE values in the range of from about 0.8 mg to about 2.5 mg and PE values in the range of about 5 mg to about 8 mg, an RDA ranging from about 25 to about 90, and an oil absorption of from about 95m1/100gm to about 135m1/100gm. Reaction parameters which affect the characteristics of the resultant silica include: the rate at which the various reactants are added; the levels of concentration of the various reactants; the reaction pH; the reaction temperature or the rate at which electrolytes are added. The formed suspension is subsequently filtered, followed by a washing and drying of the filtered precipitate. The resulting precipitated silica is next milled to a particle size in which 70% of the particle size distribution is below 20 microns.
In a separate process, gel silicas are prepared in accordance with general methods described, for example, in prior U.S. Patents: 4,153,680, to Seybert, issued May 8, 1979; 4 303,ø41, to DeWolf II et al., issued December 1, 1981 and 4.632,826, to Ploger et al., issued December 30, 1986, varying reaction parameters to form gel silicas having BE values in the range of from about 3 mg to about 15 mg and PE
values in the range of 8 mg to about 20 mg, an RDA ranging from about 80 to about 200, and an oil absorption of from about 130m1/100gm to about 60m1/100gm. Once formed, the gel silica is milled to a particle size in which 70% of the particle size distribution is below 20 microns.
The precipitated and gel silicas, next, are combined (e.g., by physical mixing) to form the amorphous silica compositions of the present invention. The resultant amorphous silica composition can then be incorporated into suitable dentifrice compositions.
In addition to the above described essential components, the dentifrice compositions of the present invention can contain a variety of optional dentifrice ingredients some of which are described below. Optional ingredients include, for example, but are not limited to, adhesives, sudsing agents, flavoring agents, sweetening agents, additional antiplaque agents, abrasives, and coloring agents.
These and other optional components are further described in U.S. Patent 5,004,597, April 2, 1991 to Majeti; U.S. Patent 4,885,155, December 5, 1989 to Parran, Jr. et al.;
U.S. Patent 3,959,458, May 25, 1976 to Agricola et al. and U.S. Patent 3,937,807, February 10, 1976 to Haefele.
The Pellicle Cleaning Ratio (PCR) of the inventive silica composition, which is a measurement of the cleaning characteristics of a dentifrice, ranges from 90 to 135 and preferably from 100 to 130 for the amorphous silica combination of the invention. The Radioactive Dentin Abrasion (RDA) of the inventive silicas, which is a measurement of the abrasiveness of the precipitated silica combination when incorporated into a dentifrice, ranges from 60 to 10, preferably from 80 to 90.
The PCR (Pellicle Cleaning Ratio) cleaning values are determined by a slightly modified version of the PCR test described in "In Vitro Removal of Stain With Dentifrice", G. K. Stookey, T.A. Burkhard and B. R. Schemerhorn, J.
Dental Research, 61, 1236-9, 1982. Cleaning is assessed in vitro by use of the modified pellicle cleaning ratio test. This test is identical to that described by Stookey et al.
with the following modifications: (1) a clear artificial pellicle film is applied to bovine chips prior to application of the stained film, (2) solution heating is used rather than radiative heating during film application, (3) the number of brush strokes is reduced to 200 strokes and (4) the slurry concentration is 1 part dentifrice to 3 parts water.
The amorphous silica combinations of the present invention, when incorporated into a dentifrice composition further provide an improved PCR/RDA
ratio. The PCR/RDA ratio is used to determine the relative ratio of cleaning and abrasion characteristics of a dentifrice formulation. Commercially available dentifrice formulations generally have a PCR/RDA ratio in the range of 0.5 to below 1Ø
The amorphous silicas used in the compositions of the present invention provide PCR to RDA ratios to dentifrice formulations of greater than 1, usually in the range of 1.20 to 1.60, but more preferably in the range 1.25 to 1.50.
The abrasive, in the form of a precipitated silica and gel silica compositions of the present invention, when incorporated into the compositions described herein, is present at a level of from about 6% to about 70%, preferably from about 15% to about 35% when the dentifi-ice is a toothpaste. Higher levels, as high as 95%, may be used if the composition is a toothpowder.
OPTIONAL COMPONENTS
Pharnnaceutically Acceptable Carrier The carrier for the components of the present compositions is optional and can be any dentifi-ice vehicle suitable for use in the oral cavity. Such carriers include the usual components of toothpastes, tooth powders, prophylaxis pastes, lozenges, gums and the like and are more fully described hereinafter. Toothpastes are the preferred systems.
Surfactants:
One of the preferred optional agents of the present invention is a surfactant, preferably one selected from the group consisting of sarcosinate surfactants, isethionate surfactants and taurate surfactants. Preferred for use herein are alkali metal or ammonium salts of these surfactants. Most preferred herein are the sodium and potassium salts of the following: lauroyl sarcosinate, myristoyl sarcosinate, palmitoyl sarcosinate, stearoyl sarcosinate and oleoyl sarcosinate.
This surfactant can be present in the compositions of the present invention from about 0.1% to about 2.5%, preferably from about 0.3% to about 2.5% and most preferably from about 0.5% to about 2.0% by weight of the total composition.
Other suitable compatible suractants can optionally be used along with the sarcosinate surfactant in the compositions of the present invention. Suitable optional suractants are described more fully in U.S. Patent 3,959,458, May 25, 1976 to Agricola et al.; U.S. Patent 3,937,807, February 10, 1976 to Haefele; and U.S.
Patent 4_.051 234_, September 27, 1988 to Gieske et al.
Preferred anionic surfactants useful herein include the water-soluble salts of alkyl sulfates having from 10 to 18 carbon atoms in the alkyl radical and the water-soluble salts of sulfonated monoglycerides of fatty acids having from 10 to 18 carbon atoms. Sodium lauryl sulfate and sodium coconut monoglyceride sulfonates are examples of anionic surfactants of this type. Mixtures of anionic surfactants can also be utilized.
Preferred cationic surfactants useful in the present invention can be broadly defined as derivatives of aliphatic quaternary ammonium compounds having one long alkyl chain containing from about 8 to 18 carbon atoms such as lauryl trimethylam-monium chloride; cetyl pyridinium chloride; cetyl trimethylammonium bromide;
di-is-obutylphenoxyethyl-dimethylbenzylammonium chloride; coconut alkyltrimethyl-ammonium nitrite; cetyl pyridinium fluoride; etc. Preferred compounds are the quaternary ammonium fluorides described in U.S. Patent 3,535,421, October 20, 1970, to Briner et al., quaternary ammonium fluorides have detergent properties.
Certain cationic surfactants can also act as germicides in the compositions disclosed herein. Cationic surfactants such as chlorhexadine, although suitable for use in the current invention, are not preferred due to their capacity to stain the oral cavity's hard tissues. Persons skilled in the art are aware of this possibility and should incorporate cationic surfactants only with this limitation in mind.
Preferred nonionic surfactants that can be used in the compositions of the present invention can be broadly defined as compounds produced by the condensation of the alkylene oxide groups (hydrophilic in nature) with an organic hydrophobic compound which may be aliphatic or alkylaromatic in nature. Examples of suitable nonionic surfactants include the Pluronics, polyethylene oxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide with the reaction product of propylene oxide and ethylene diamine, ethylene oxide condensates of aliphatic alcohols, long chain tertiary amine oxides, long chain tertiary phosphine oxides, long chain dialkyl sulfoxides and mixtures of such materials.
Preferred zwitterionic synthetic surfactants useful in the present invention can be broadly described as derivatives of aliphatic quaternary ammonium, phos-phomium, and sulfonium compounds, in which the aliphatic radicals can be straight chain or branched, and wherein one of the aliphatic substituents contains from about 8 to 18 carbon atoms and one contains an anionic water-solubilizing group, e.g., carboxy, sulfonate, sulfate, phosphate or phosphonate.
Preferred betaine surfactants are disclosed in U.S. Patent 5,180,577 to Poleflca et al., issued January 19, 1993. Typical alkyl dimethyl betaines include decyl betaine or 2-(N-decyl-N,N-dimethylammonio) acetate, coco betaine or 2-(N-coc-N, N-dimethyl ammonio) acetate, myristyl betaine, palmityl betaine, lauryl betaine, cetyl betaine, cetyl betaine, stearyl betaine, etc. The amidobetaines are exemplified by cocoamidoethyl betaine, cocoamidopropyl betaine, lauramidopropyl betaine and the like. The betaines of choice are preferably the cocoamidopropyl betaine and, more preferably, the lauramido propyl betaine.
Chelating-agents:
Another preferred optional agent is a chelating agent selected from the group consisting of tartaric acid and pharmaceutically-acceptable salts thereof, citric acid and alkali metal citrates and mixtures thereof. Chelating agents are able to complex calcium found in the cell walls of the bacteria. Chelating agents can also disrupt plaque by removing calcium from the calcium bridges which help hold this biomass intact. However, it is possible to use a chelating agent which has an affinity for calcium that is too high. This results in tooth demineralization and is contrary to the objects and intentions of the present invention.
Sodium and potassium citrate are the preferred alkali metal citrates, with sodium citrate being the most preferred. Also preferred is a citric acidlalkali metal citrate combination. Preferred herein are alkali metal salts of tartaric acid.
Most preferred for use herein are disodium tartrate, dipotassium tartrate, sodium potassium tartrate, sodium hydrogen tartrate and potassium hydrogen tartrate. The amounts of chelating agent suitable for use in the present invention are about 0.1% to about 2.5%, preferably from about 0.5% to about 2.5% and more preferably from about 1.0% to about 2.5%. The tartaric acid salt chelating agent can be used alone or in combination with other optional chelating agents.
TECHNICAL FIELD
This invention relates to dentifrice compositions such as toothpastes which ' provide improved oral cleaning.
BACKGROUND OF THE INVENTION
Synthetically produced amorphous silicas play an important role as an ingredient in many of today's toothpaste formulations. In addition to their cleaning albility, they are also relatively safe, nontoxic, and compatible with other toothpaste ingredients, including glycerin, sorbitol (or xylitol), thickening agents, detergents coloring and fragrance materials and, optionally, fluoride containing compositions.
Synthetic precipitated silicas are prepared by admixing dilute alkali silicate solutions with strong aqueous mineral acids under conditions where aggregation to the sol and gel cannot occur, stirring and then filtering out the precipitated silica.
The resulting precipitate is next washed, dried and comminuted to desired size.
Silica gels include silica hydrogels, hydrous gels, aerogels, and xerogels.
Silica gels are also formed by reacting alkali silicate solutions with strong acids to form a hydrosol and aging the newly formed hydrosol to form the hydrogel. The hydrogel is then washed, dried and comminuted as described above.
When preparing synthetic silicas, the objective is to obtain silicas which provide maximal cleaning with minimal damage to oral tissue. Dental researchers are continually concerned with identifying precipitated silicas meeting these objectives.
Examples of precipitated silicas described in the art include U.S. Patent 4 122.161 to Wason, October 24, 1978, U. S. Patents 4.992.251 and 5.03 S 879 to Aldcroft et al., February 12, 1991 and July 30, 1991 respectively, U.S. Patent 5 098_695 to Newton et al., March 24, 1992, and U.S. Patent 5.279.815 to Wason et al., January 18, 1994. Similarly, silica gels have also been described in the art as demonstrated by U.S. Patent 4,303,641. December 1, 1981, to DeWolf, II et al., U.S. Patent 4.153,680, May 8, 1979, to Seybert, and U.S. Patent 3.538.230, November 3, 1970, to Pader et al..
Moreover, various combinations of silicas have been described in the art.
Silica combinations involving compositions of differing particle sizes and specific surface areas are disclosed in U.S. Patent .3.577,521 to Karlheinz Scheller et al., May 4, 1971 and U.S. Patent 4.618.488 to Maeyama et al., October 21, 1986, respectively. Similarly, U.S. Patents 5.110.574 to Reinhardt et al., May 5, discloses combining precipitated thickener and polishing silicas to form silica compositions having oil absorption values of at least 200. Further examples of silica combinations include U.S. Patent 5.124.143 to Muhlemann, June 23, 1992 and U.S.
Patent 4.632.826 to Ploger et al., December 30, 1986.
While the prior art discloses a variety of silica compositions useful as dental °
cleaning abrasives, there is still a need for additional compositions providing improved cleaning with minimal abrasion. The present inventor has discovered °
amorphous silica abrasive compositions comprising precipitated and gel silicas providing improved dental cleaning with minimal abrasion.
Accordingly, it is the object of the present invention to provide a precipitated silica and gel silica compositions providing improved pellicle cleaning without a corresponding increase in dentin or enamel abrasion. Another object of the present invention is to provide an improved method for the prevention or removal tooth stains. A further object of the present invention is to provide an improved method for the prevention or removal of plaque. These and other objects will become readily apparent from the disclosure which follows.
SUMMARY OF THE INVENTION
The present invention relates to amorphous silica abrasive compositions, comprising:
a.) a precipitated silica, comprising particles wherein said particles have:
i.) a mean particle size of from about 5 to about 11 microns (s.d. < 9);
ii.) an Einlehner hardness of from about 0.8 to about 2.5 for abrasive to brass screen and from about 5 to about 8 for abrasive to polyester screen;
iii.) an oil absorption of from about 95 ml/100 gm to about 135 ml/100 gm; and iv.) a radioactive dentin abrasion of from about 25 to about 90;
and b.) a gel silica, comprising particles wherein said particles have:
i.) a mean particle size of from about 5 to about 11 °
microns (s.d. < 9);
ii.) an Einlehner hardness of from about 3 to about I 5 for abrasive to brass screen and from about 8 to about 20 for abrasive to polyester screen;
WO 961'34593 PCT/US96/45497 iii.) . an oil absorption of from about 60 ml/100 gm to about 130 ml/100 gm; and iv) a radioactive dentin abrasion of from about 80 to about 200 v~~herein at least about 70% of all of said particles have a diameter of below about 25 i rrucrons and wherein the pellicle cleaning ratio is from about 90 to about 135 and the radioactive dentin abrasion is from about 60 to about 100 with a pellicle cleaning ratio/radioactive dentin abrasion ratio of from about 1.20 to about 1.60 and wherein the ratio of precipitated silica to gel silica is from about 90:10 to about 60:40, respectively.
All levels and ratios are by weight of the total composition, unless otherwise indicated. Additionally, all measurements are made at 25C
unless otherwise specified.
The pH of the present herein described compositions range from about 4 to about 9.5, with the preferred pH being from about 6.5 to about 9.0 and the most preferred pH being 7.0 to about 8.5, as measured in a 5%
aqueous slurry.
DETAILED DESCRIPTION OF THE INVENTION
By "safe and effective amount," as used herein, means a suffcient amount to reduce stain and/or plaque/gingivitis without harming the tissues and structures of the oral cavity.
By the term "orally-acceptable carrier," as used herein, means a suitable vehicle which can be used to apply the present compositions to the oral cavity in a safe and effective manner.
The essential as well as optional components of the compositions of the present invention are described in the following paragraphs.
've The amorphous silicas used to form the precipitated silica and gel silica combinations of the present invention can be characterized as either Low Structure or Medium Structure silicas in accordance with the definitions set forth in the J. Soc.
Cosmet. Chem. 29., 497-521 (August, 1978), and Pigment Handbook:
Volume 1, Properties and Economics, Second Edition, Edited by Peter A. Lewis, John Wiley &
Sons, Inc., 1988, p. 139-159 and are preferably characterized as synthetic hydrated amorphous silicas, also known as silicon dioxides or Si02.
Further, these silicas may be characterized as having a BET surface area in the range of 50 to 250 m2/g. and as containing less than about 10%, more preferably less than about 5%, alumina.
The amorphous silica combinations of the present invention may be characterized as having a median average particle size ranging from about 5 microns to about 11 microns with at least 70% of the particle size distribution being less than 20 microns. The average particle size (mean value and median or 50%) is measured using a MicrotracTM II apparatus, Leeds and Northrup. Specifically, a laser beam is projected through a transparent cell, which contains a stream of moving particles suspended in a liquid. Light rays which strike the particles are scattered through angles which are inversely proportional to their sizes. The photodetector array measures the quantity of light at several predetermined angles. Electrical signals proportional to the measured light flux values are then processed by a microcomputer system to form a multi-channel histogram of the particle size distribution.
The amorphous precipitated and gel silicas used to form the combinatory compositions of the present invention are further characterized by means of their respective Einlehner hardness values, Radioactive Dentin Abrasion (RDA) values and oil absorption values.
Einlehner hardness values are measured using an Einlehner At-1000 Abrader to measure the softness of the silicas in the following manner: A Fourdrinier wire screen is weighed and exposed to the action of a 10% aqueous silica suspension for a certain length of time. The amount of abrasion is then determined as milligrams weight lost of the Fourdrinier wire screen per 100,000 revolutions. Brass Einlehner (BE) and Polyester Einlehner (PE) results are expressed in milligrams.
The RDA values are determined according to the method set forth by Hefferren, Journal of Dental Research, July-August 1976, pp. 563-573, and described in the Wason U.S. Patents 4_,,340,583, 4;420"312 and 4_,,421,527.
The amorphous silica combinations are, preferably, characterized as having oil absorption values less than 200 cc/ 100 gm. Oil absorption values are measured using the ASTM rub-out method D281. Surface area is determined by the BET
nitrogen adsorption method of Brunaur et al., J. Am. Chem. Soc., 60, 309 (1938). To measure brightness, fine powder materials that are pressed into a smooth surfaced pellet are evaluated using a Technidyne BrightimeterTM S-SBC. This instrument has a dual beam optical system where the sample is illuminated at an angle of 45°, and the reflected light viewed at 0°. It conforms to TAPPI test methods T452 and T646, and ASTM Standard D985. A series of filters direct to reflected light of desired wavelengths to a photocell where it is converted to an output voltage. This signal is amplified and then processed by an internal microcomputer for display and printout.
Precipitated silica suspensions are prepared in accordance with general methods described, for example, in prior U.S. Patents: 3. 893,840, issued July 8, 1975, to Wason; 3_.988,162, issued October 26, 1976, to Wason, 4.067,246, issued January 10, 1978, to Wason; and 4_,340,583, issued July 29, 1982, to Wason:
varying reaction parameters to form precipitated silicas having BE values in the range of from about 0.8 mg to about 2.5 mg and PE values in the range of about 5 mg to about 8 mg, an RDA ranging from about 25 to about 90, and an oil absorption of from about 95m1/100gm to about 135m1/100gm. Reaction parameters which affect the characteristics of the resultant silica include: the rate at which the various reactants are added; the levels of concentration of the various reactants; the reaction pH; the reaction temperature or the rate at which electrolytes are added. The formed suspension is subsequently filtered, followed by a washing and drying of the filtered precipitate. The resulting precipitated silica is next milled to a particle size in which 70% of the particle size distribution is below 20 microns.
In a separate process, gel silicas are prepared in accordance with general methods described, for example, in prior U.S. Patents: 4,153,680, to Seybert, issued May 8, 1979; 4 303,ø41, to DeWolf II et al., issued December 1, 1981 and 4.632,826, to Ploger et al., issued December 30, 1986, varying reaction parameters to form gel silicas having BE values in the range of from about 3 mg to about 15 mg and PE
values in the range of 8 mg to about 20 mg, an RDA ranging from about 80 to about 200, and an oil absorption of from about 130m1/100gm to about 60m1/100gm. Once formed, the gel silica is milled to a particle size in which 70% of the particle size distribution is below 20 microns.
The precipitated and gel silicas, next, are combined (e.g., by physical mixing) to form the amorphous silica compositions of the present invention. The resultant amorphous silica composition can then be incorporated into suitable dentifrice compositions.
In addition to the above described essential components, the dentifrice compositions of the present invention can contain a variety of optional dentifrice ingredients some of which are described below. Optional ingredients include, for example, but are not limited to, adhesives, sudsing agents, flavoring agents, sweetening agents, additional antiplaque agents, abrasives, and coloring agents.
These and other optional components are further described in U.S. Patent 5,004,597, April 2, 1991 to Majeti; U.S. Patent 4,885,155, December 5, 1989 to Parran, Jr. et al.;
U.S. Patent 3,959,458, May 25, 1976 to Agricola et al. and U.S. Patent 3,937,807, February 10, 1976 to Haefele.
The Pellicle Cleaning Ratio (PCR) of the inventive silica composition, which is a measurement of the cleaning characteristics of a dentifrice, ranges from 90 to 135 and preferably from 100 to 130 for the amorphous silica combination of the invention. The Radioactive Dentin Abrasion (RDA) of the inventive silicas, which is a measurement of the abrasiveness of the precipitated silica combination when incorporated into a dentifrice, ranges from 60 to 10, preferably from 80 to 90.
The PCR (Pellicle Cleaning Ratio) cleaning values are determined by a slightly modified version of the PCR test described in "In Vitro Removal of Stain With Dentifrice", G. K. Stookey, T.A. Burkhard and B. R. Schemerhorn, J.
Dental Research, 61, 1236-9, 1982. Cleaning is assessed in vitro by use of the modified pellicle cleaning ratio test. This test is identical to that described by Stookey et al.
with the following modifications: (1) a clear artificial pellicle film is applied to bovine chips prior to application of the stained film, (2) solution heating is used rather than radiative heating during film application, (3) the number of brush strokes is reduced to 200 strokes and (4) the slurry concentration is 1 part dentifrice to 3 parts water.
The amorphous silica combinations of the present invention, when incorporated into a dentifrice composition further provide an improved PCR/RDA
ratio. The PCR/RDA ratio is used to determine the relative ratio of cleaning and abrasion characteristics of a dentifrice formulation. Commercially available dentifrice formulations generally have a PCR/RDA ratio in the range of 0.5 to below 1Ø
The amorphous silicas used in the compositions of the present invention provide PCR to RDA ratios to dentifrice formulations of greater than 1, usually in the range of 1.20 to 1.60, but more preferably in the range 1.25 to 1.50.
The abrasive, in the form of a precipitated silica and gel silica compositions of the present invention, when incorporated into the compositions described herein, is present at a level of from about 6% to about 70%, preferably from about 15% to about 35% when the dentifi-ice is a toothpaste. Higher levels, as high as 95%, may be used if the composition is a toothpowder.
OPTIONAL COMPONENTS
Pharnnaceutically Acceptable Carrier The carrier for the components of the present compositions is optional and can be any dentifi-ice vehicle suitable for use in the oral cavity. Such carriers include the usual components of toothpastes, tooth powders, prophylaxis pastes, lozenges, gums and the like and are more fully described hereinafter. Toothpastes are the preferred systems.
Surfactants:
One of the preferred optional agents of the present invention is a surfactant, preferably one selected from the group consisting of sarcosinate surfactants, isethionate surfactants and taurate surfactants. Preferred for use herein are alkali metal or ammonium salts of these surfactants. Most preferred herein are the sodium and potassium salts of the following: lauroyl sarcosinate, myristoyl sarcosinate, palmitoyl sarcosinate, stearoyl sarcosinate and oleoyl sarcosinate.
This surfactant can be present in the compositions of the present invention from about 0.1% to about 2.5%, preferably from about 0.3% to about 2.5% and most preferably from about 0.5% to about 2.0% by weight of the total composition.
Other suitable compatible suractants can optionally be used along with the sarcosinate surfactant in the compositions of the present invention. Suitable optional suractants are described more fully in U.S. Patent 3,959,458, May 25, 1976 to Agricola et al.; U.S. Patent 3,937,807, February 10, 1976 to Haefele; and U.S.
Patent 4_.051 234_, September 27, 1988 to Gieske et al.
Preferred anionic surfactants useful herein include the water-soluble salts of alkyl sulfates having from 10 to 18 carbon atoms in the alkyl radical and the water-soluble salts of sulfonated monoglycerides of fatty acids having from 10 to 18 carbon atoms. Sodium lauryl sulfate and sodium coconut monoglyceride sulfonates are examples of anionic surfactants of this type. Mixtures of anionic surfactants can also be utilized.
Preferred cationic surfactants useful in the present invention can be broadly defined as derivatives of aliphatic quaternary ammonium compounds having one long alkyl chain containing from about 8 to 18 carbon atoms such as lauryl trimethylam-monium chloride; cetyl pyridinium chloride; cetyl trimethylammonium bromide;
di-is-obutylphenoxyethyl-dimethylbenzylammonium chloride; coconut alkyltrimethyl-ammonium nitrite; cetyl pyridinium fluoride; etc. Preferred compounds are the quaternary ammonium fluorides described in U.S. Patent 3,535,421, October 20, 1970, to Briner et al., quaternary ammonium fluorides have detergent properties.
Certain cationic surfactants can also act as germicides in the compositions disclosed herein. Cationic surfactants such as chlorhexadine, although suitable for use in the current invention, are not preferred due to their capacity to stain the oral cavity's hard tissues. Persons skilled in the art are aware of this possibility and should incorporate cationic surfactants only with this limitation in mind.
Preferred nonionic surfactants that can be used in the compositions of the present invention can be broadly defined as compounds produced by the condensation of the alkylene oxide groups (hydrophilic in nature) with an organic hydrophobic compound which may be aliphatic or alkylaromatic in nature. Examples of suitable nonionic surfactants include the Pluronics, polyethylene oxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide with the reaction product of propylene oxide and ethylene diamine, ethylene oxide condensates of aliphatic alcohols, long chain tertiary amine oxides, long chain tertiary phosphine oxides, long chain dialkyl sulfoxides and mixtures of such materials.
Preferred zwitterionic synthetic surfactants useful in the present invention can be broadly described as derivatives of aliphatic quaternary ammonium, phos-phomium, and sulfonium compounds, in which the aliphatic radicals can be straight chain or branched, and wherein one of the aliphatic substituents contains from about 8 to 18 carbon atoms and one contains an anionic water-solubilizing group, e.g., carboxy, sulfonate, sulfate, phosphate or phosphonate.
Preferred betaine surfactants are disclosed in U.S. Patent 5,180,577 to Poleflca et al., issued January 19, 1993. Typical alkyl dimethyl betaines include decyl betaine or 2-(N-decyl-N,N-dimethylammonio) acetate, coco betaine or 2-(N-coc-N, N-dimethyl ammonio) acetate, myristyl betaine, palmityl betaine, lauryl betaine, cetyl betaine, cetyl betaine, stearyl betaine, etc. The amidobetaines are exemplified by cocoamidoethyl betaine, cocoamidopropyl betaine, lauramidopropyl betaine and the like. The betaines of choice are preferably the cocoamidopropyl betaine and, more preferably, the lauramido propyl betaine.
Chelating-agents:
Another preferred optional agent is a chelating agent selected from the group consisting of tartaric acid and pharmaceutically-acceptable salts thereof, citric acid and alkali metal citrates and mixtures thereof. Chelating agents are able to complex calcium found in the cell walls of the bacteria. Chelating agents can also disrupt plaque by removing calcium from the calcium bridges which help hold this biomass intact. However, it is possible to use a chelating agent which has an affinity for calcium that is too high. This results in tooth demineralization and is contrary to the objects and intentions of the present invention.
Sodium and potassium citrate are the preferred alkali metal citrates, with sodium citrate being the most preferred. Also preferred is a citric acidlalkali metal citrate combination. Preferred herein are alkali metal salts of tartaric acid.
Most preferred for use herein are disodium tartrate, dipotassium tartrate, sodium potassium tartrate, sodium hydrogen tartrate and potassium hydrogen tartrate. The amounts of chelating agent suitable for use in the present invention are about 0.1% to about 2.5%, preferably from about 0.5% to about 2.5% and more preferably from about 1.0% to about 2.5%. The tartaric acid salt chelating agent can be used alone or in combination with other optional chelating agents.
Other optional chelating agents can be used. Preferably these chelating agents have a calcium binding constant of about 10' to 105 provide improved cleaning with reduced plaque and calculus formation.
Another group of agents suitable for use as chelating agents in the present invention are the soluble pyrophosphates. The pyrophosphate salts used in the present compositions can be any of the alkali metal pyrophosphate salts.
Specific salts include tetra alkali metal pyrophosphate, dialkali metal diacid pyrophosphate, trialkali metal monoacid pyrophosphate and mixtures thereof, wherein the alkali metals are preferably sodium or potassium. The salts are useful in both their hydrated and unhydrated forms. An effective amount of pyrophosphate salt useful in the present composition is generally enough to provide at least 1.0% pyrophosphate ion, preferably from about 1.5% to about 6%, more preferably from about 3.5% to about 6% of such ions. It is to be appreciated that the level of pyrophosphate ions is that capable of being provided to the composition (i.e., the theoretical amount at an appropriate pH) and that pyrophosphate forms other than P20~~(e.g., (HP20~-3)) may be present when a final product pH is established.
The pyrophosphate salts are described in more detail in Kirk & Othmer, Enc,~pedia of Chemical Technoloav, Second Edition, Volume 15, Interscience Publishers ( 1968).
Still another possible group of chelating agents suitable for use in the present invention are the anionic polymeric polycarboxylates. Such materials are well known in the art, being employed in the form of their free acids or partially or preferably fully neutralized water soluble alkali metal (e.g. potassium and preferably sodium) or ammonium salts. Preferred are 1:4 to 4:1 copolymers of malefic anhydride or acid with another polymerizable ethylenically unsaturated monomer, preferably methyl vinyl ether (methoxyethylene) having a molecular weight (M.W.) of about 30,000 to about 1,000,000. These copolymers are available for example as GantrezTM AN
(M.W. 500,000), AN 119 (M.W. 250,000) and preferably S-97 Pharmaceutical Grade (M.W. 70,000), of GAF Chemicals Corporation.
Other operative polymeric polycarboxylates include those such as the 1:1 copolymers of malefic anhydride with ethyl acrylate, hydroxyethyl methacrylate, N-vinyl-2-pyrollidone, or ethylene, the latter being available for example as Monsanto EMA No. 1103, M.W. 10,000 and EMA Grade 61, and 1:1 copolymers of acrylic acid with methyl or hydroxyethyl methacrylate, methyl or ethyl acrylate, isobutylvinyl ether or N-vinyl-2-pyrrolidone.
Additional operative polymeric polycarboxylates are disclosed in U.S. Patent 4~138T477, February 6, 1979 to Gaffar and U.S. Patent 4,183,914, January 15, to Gaffar et al. and include copolymers or malefic anhydride with styrene, isobutylene or ethyl vinyl ether, polyacrylic, polyitaconic and polymaleic acids, and sulfoacrylic oligomers of M.W. as low as 1,000 available as UniroyalTM ND-2.
Flavoring agents can also be added to dentifrice compositions. Suitable flavoring agents include oil of wintergreen, oil of peppermint, oil of spearmint, oil of sassafras, and oil of clove. Sweetening agents which can be used include aspartame, acesulfame, saccharin, dextrose, levulose and sodium cyclamate. Flavoring and sweetening agents are generally used in dentifrices at levels of from about 0.005% to about 2% by weight.
It is common to have a water-soluble fluoride compound present in dentifrices and other oral compositions in an amount sufficient to give a fluoride ion concentration in the composition at 25°C, and/or when it is used of from about 0.0025% to about 5.0% by weight, preferably from about 0.005% to about 2.0% by weight, to provide additional anticaries effectiveness. A wide variety of fluoride ion-yielding materials can be employed as sources of soluble fluoride in the present compositions. Examples of suitable fluoride ion-yielding materials are found in Ice,, Patent No. 3,5350.421, October 20, 1970 to Briner et al. and U.S. Patent No.
3_.678.1 ~_4, July 18, 1972 to Widder et al. Representative fluoride ion sources include:
stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate and many others. Stannous fluoride and sodium fluoride are particularly preferred, as well as mixtures thereof.
Water is also present in the toothpastes of this invention. Water employed in the preparation of commercially suitable toothpastes should preferably be deionized and free of organic impurities. Water generally comprises from about 10% to 50%, preferably from about 20% to 40%, by weight of the toothpaste compositions herein.
These amounts of water include the free water which is added plus that which is introduced with other materials such as with sorbitol.
In preparing toothpastes, it is necessary to add some thickening material to provide a desirable consistency. Preferred thickening agents are carboxyvinyl polymers, carrageenan, hydroxethyl cellulose and water-soluble salts of cellulose ethers such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxethyl cellulose. Natural gums such as gum karaya, xanthan gum, gum arabic, and gum tragacanth can also be used. Thickening agents in an amount from 0.5%
to 5.0% by weight of the total composition can be used.
ll It is also desirable to include some humectant material in a toothpaste to keep it from hardening. Suitable humectants include glycerin, sorbital, and other edible polyhydric alcohols at a level of from about 15% to about 70%.
Also desirable for inclusion in the compositions of the present invention are other stannous salts such as stannous pyrophosphate and stannous gluconate and antimicrobials such as quaternary ammonium salts, such as cetyl pyridinium chloride and tetradecylethyl pyridinium chloride, bis-biquanide salts, copper bisglycinate, nonionic antimicrobial salts and flavor oils. Such agents are disclosed in U.S. Patent No. 2,,946,725, July 26, 1960, to Norris et al. and U.S. Patent No. 4,Q51,234, September 27, 1977 to Gieske et al. Other optional components include buffering agents, bicarbonates, peroxides, nitrate salts such as sodium and potassium nitrate.
These agents, if present, are included at levels of from about 0.01% to about 30%.
Other useful carriers include biphasic dentifrice formulations such as those disclosed in LJ.S. Patents S.~a790, issued May 23, 1993, x,145,666, issued September 8, 1992, and 5 ~$1~Q issued January 25, 1994 all to Lukacovic et al.
and in U.S. Patents 4,849,213 and 4.528,180 to Schaeffer.
Suitable lozenge and chewing gum components are disclosed in U.S. Patent No. 4,083,955, April 11, 1978 to Grabenstetter et al.
EXAMPLES
The following examples further describe and demonstrate preferred embodiments within the scope of the present invention. The examples are given solely for illustration, and are not to be construed as limitation of this invention as many variations thereof are possible without departing from its spirit and scope.
~xammle 1 A dentifrice composition of the present invention contains the following components as described below.
Component Wgt Sorbitol 70% soln 24.200 RO Water 24.757 Glycerin 7.000 Carboxymethyl Cellulose'0.500 PEG 6 4.000 Sodium Fluoride 0.243 Sodium Saccharine 0.130 WO 96/34593 PC'T/LTS96/05497 Monosodium Phosphate 0.415 Trisodium Phosphate 0.395 Sodium Tartrate 1.000 r Ti02 0.500 Silica2 35.000 r Sodium Lauroyl Sarcosinate (95% active) 1.060 Flavor 0.800 1 Supplied by Aqualon Company.
2The amorphous silica ingredient possesses the following characteristics: APS
Mean Value = 8.3 microns; oil absorption = 108cc/100g; BE = 2.6; PE = 9; PCR = 118;
RDA = 80.
The jacket temperature of a mixing tank is set to about 150°F
(65°C) to about 160°F (71°C). The humectants and water are added to the mixing tank and agitation is started. When the temperature reaches approximately 120°F
(50°C) fluoride, sweetening agents, buffering agents, chelant, coloring agents and titanium dioxide are added. Thickening agents are added to the abrasive and the resulting mixture is added to the mixing tank with high agitation. The surfactant is added to the combination and mixing is continued. The tank is cooled to 120°F
(50°C) and the flavoring agents are added. Mixing is continued for approximately 5 minutes.
The resulting composition will have a pH of about 7.
Example II
A dentifrice composition of the present invention contains the following com-ponents as described below.
Component Wgt Sorbitol 70% soln 29.810 RO Water 24.757 Glycerin 7.000 Carboxymethyl Cellulose) 0.750 PEG 6 4.000 Sodium Fluoride 0.243 Sodium Saccharine 0.130 Monosodium Phosphate 0.415 Trisodium Phosphate 0.395 Ti02 0.500 Silica2 30.000 Sodium Lauryl Sulfate 1.200 Flavor 0.800 WO 96,/34593 PCT/iTS96105497 Supplied by Aqualon Company.
%~The amorphous silica ingredient possesses the following characteristics: APS
Mean 'Jalue = 8.3 microns; oil absorption = 108cc/100g; BE = 2.6; PE = 9; PCR =
118;
RDA = 80.
Example III
A gum composition of the present invention contains the following com-ponents as described below.
Component Weight Gum Base 30.000 30 parts Estergum 45 parts Coumorone Resin parts Dry Latex Silical 10.00 Sugar 40.000 15 Corn Syrup 18.175 Sodium Lauroyl Sarcosinate 0.075 Sodium Tartrate 0.250 Flavor 1.500 /The amorphous silica ingredient possesses the following characteristics: APS
Mean ''alue = 8.2 microns; oil absorption = 106 cc/100g; BE = 3.3; PE = 10.
Another group of agents suitable for use as chelating agents in the present invention are the soluble pyrophosphates. The pyrophosphate salts used in the present compositions can be any of the alkali metal pyrophosphate salts.
Specific salts include tetra alkali metal pyrophosphate, dialkali metal diacid pyrophosphate, trialkali metal monoacid pyrophosphate and mixtures thereof, wherein the alkali metals are preferably sodium or potassium. The salts are useful in both their hydrated and unhydrated forms. An effective amount of pyrophosphate salt useful in the present composition is generally enough to provide at least 1.0% pyrophosphate ion, preferably from about 1.5% to about 6%, more preferably from about 3.5% to about 6% of such ions. It is to be appreciated that the level of pyrophosphate ions is that capable of being provided to the composition (i.e., the theoretical amount at an appropriate pH) and that pyrophosphate forms other than P20~~(e.g., (HP20~-3)) may be present when a final product pH is established.
The pyrophosphate salts are described in more detail in Kirk & Othmer, Enc,~pedia of Chemical Technoloav, Second Edition, Volume 15, Interscience Publishers ( 1968).
Still another possible group of chelating agents suitable for use in the present invention are the anionic polymeric polycarboxylates. Such materials are well known in the art, being employed in the form of their free acids or partially or preferably fully neutralized water soluble alkali metal (e.g. potassium and preferably sodium) or ammonium salts. Preferred are 1:4 to 4:1 copolymers of malefic anhydride or acid with another polymerizable ethylenically unsaturated monomer, preferably methyl vinyl ether (methoxyethylene) having a molecular weight (M.W.) of about 30,000 to about 1,000,000. These copolymers are available for example as GantrezTM AN
(M.W. 500,000), AN 119 (M.W. 250,000) and preferably S-97 Pharmaceutical Grade (M.W. 70,000), of GAF Chemicals Corporation.
Other operative polymeric polycarboxylates include those such as the 1:1 copolymers of malefic anhydride with ethyl acrylate, hydroxyethyl methacrylate, N-vinyl-2-pyrollidone, or ethylene, the latter being available for example as Monsanto EMA No. 1103, M.W. 10,000 and EMA Grade 61, and 1:1 copolymers of acrylic acid with methyl or hydroxyethyl methacrylate, methyl or ethyl acrylate, isobutylvinyl ether or N-vinyl-2-pyrrolidone.
Additional operative polymeric polycarboxylates are disclosed in U.S. Patent 4~138T477, February 6, 1979 to Gaffar and U.S. Patent 4,183,914, January 15, to Gaffar et al. and include copolymers or malefic anhydride with styrene, isobutylene or ethyl vinyl ether, polyacrylic, polyitaconic and polymaleic acids, and sulfoacrylic oligomers of M.W. as low as 1,000 available as UniroyalTM ND-2.
Flavoring agents can also be added to dentifrice compositions. Suitable flavoring agents include oil of wintergreen, oil of peppermint, oil of spearmint, oil of sassafras, and oil of clove. Sweetening agents which can be used include aspartame, acesulfame, saccharin, dextrose, levulose and sodium cyclamate. Flavoring and sweetening agents are generally used in dentifrices at levels of from about 0.005% to about 2% by weight.
It is common to have a water-soluble fluoride compound present in dentifrices and other oral compositions in an amount sufficient to give a fluoride ion concentration in the composition at 25°C, and/or when it is used of from about 0.0025% to about 5.0% by weight, preferably from about 0.005% to about 2.0% by weight, to provide additional anticaries effectiveness. A wide variety of fluoride ion-yielding materials can be employed as sources of soluble fluoride in the present compositions. Examples of suitable fluoride ion-yielding materials are found in Ice,, Patent No. 3,5350.421, October 20, 1970 to Briner et al. and U.S. Patent No.
3_.678.1 ~_4, July 18, 1972 to Widder et al. Representative fluoride ion sources include:
stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate and many others. Stannous fluoride and sodium fluoride are particularly preferred, as well as mixtures thereof.
Water is also present in the toothpastes of this invention. Water employed in the preparation of commercially suitable toothpastes should preferably be deionized and free of organic impurities. Water generally comprises from about 10% to 50%, preferably from about 20% to 40%, by weight of the toothpaste compositions herein.
These amounts of water include the free water which is added plus that which is introduced with other materials such as with sorbitol.
In preparing toothpastes, it is necessary to add some thickening material to provide a desirable consistency. Preferred thickening agents are carboxyvinyl polymers, carrageenan, hydroxethyl cellulose and water-soluble salts of cellulose ethers such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxethyl cellulose. Natural gums such as gum karaya, xanthan gum, gum arabic, and gum tragacanth can also be used. Thickening agents in an amount from 0.5%
to 5.0% by weight of the total composition can be used.
ll It is also desirable to include some humectant material in a toothpaste to keep it from hardening. Suitable humectants include glycerin, sorbital, and other edible polyhydric alcohols at a level of from about 15% to about 70%.
Also desirable for inclusion in the compositions of the present invention are other stannous salts such as stannous pyrophosphate and stannous gluconate and antimicrobials such as quaternary ammonium salts, such as cetyl pyridinium chloride and tetradecylethyl pyridinium chloride, bis-biquanide salts, copper bisglycinate, nonionic antimicrobial salts and flavor oils. Such agents are disclosed in U.S. Patent No. 2,,946,725, July 26, 1960, to Norris et al. and U.S. Patent No. 4,Q51,234, September 27, 1977 to Gieske et al. Other optional components include buffering agents, bicarbonates, peroxides, nitrate salts such as sodium and potassium nitrate.
These agents, if present, are included at levels of from about 0.01% to about 30%.
Other useful carriers include biphasic dentifrice formulations such as those disclosed in LJ.S. Patents S.~a790, issued May 23, 1993, x,145,666, issued September 8, 1992, and 5 ~$1~Q issued January 25, 1994 all to Lukacovic et al.
and in U.S. Patents 4,849,213 and 4.528,180 to Schaeffer.
Suitable lozenge and chewing gum components are disclosed in U.S. Patent No. 4,083,955, April 11, 1978 to Grabenstetter et al.
EXAMPLES
The following examples further describe and demonstrate preferred embodiments within the scope of the present invention. The examples are given solely for illustration, and are not to be construed as limitation of this invention as many variations thereof are possible without departing from its spirit and scope.
~xammle 1 A dentifrice composition of the present invention contains the following components as described below.
Component Wgt Sorbitol 70% soln 24.200 RO Water 24.757 Glycerin 7.000 Carboxymethyl Cellulose'0.500 PEG 6 4.000 Sodium Fluoride 0.243 Sodium Saccharine 0.130 WO 96/34593 PC'T/LTS96/05497 Monosodium Phosphate 0.415 Trisodium Phosphate 0.395 Sodium Tartrate 1.000 r Ti02 0.500 Silica2 35.000 r Sodium Lauroyl Sarcosinate (95% active) 1.060 Flavor 0.800 1 Supplied by Aqualon Company.
2The amorphous silica ingredient possesses the following characteristics: APS
Mean Value = 8.3 microns; oil absorption = 108cc/100g; BE = 2.6; PE = 9; PCR = 118;
RDA = 80.
The jacket temperature of a mixing tank is set to about 150°F
(65°C) to about 160°F (71°C). The humectants and water are added to the mixing tank and agitation is started. When the temperature reaches approximately 120°F
(50°C) fluoride, sweetening agents, buffering agents, chelant, coloring agents and titanium dioxide are added. Thickening agents are added to the abrasive and the resulting mixture is added to the mixing tank with high agitation. The surfactant is added to the combination and mixing is continued. The tank is cooled to 120°F
(50°C) and the flavoring agents are added. Mixing is continued for approximately 5 minutes.
The resulting composition will have a pH of about 7.
Example II
A dentifrice composition of the present invention contains the following com-ponents as described below.
Component Wgt Sorbitol 70% soln 29.810 RO Water 24.757 Glycerin 7.000 Carboxymethyl Cellulose) 0.750 PEG 6 4.000 Sodium Fluoride 0.243 Sodium Saccharine 0.130 Monosodium Phosphate 0.415 Trisodium Phosphate 0.395 Ti02 0.500 Silica2 30.000 Sodium Lauryl Sulfate 1.200 Flavor 0.800 WO 96,/34593 PCT/iTS96105497 Supplied by Aqualon Company.
%~The amorphous silica ingredient possesses the following characteristics: APS
Mean 'Jalue = 8.3 microns; oil absorption = 108cc/100g; BE = 2.6; PE = 9; PCR =
118;
RDA = 80.
Example III
A gum composition of the present invention contains the following com-ponents as described below.
Component Weight Gum Base 30.000 30 parts Estergum 45 parts Coumorone Resin parts Dry Latex Silical 10.00 Sugar 40.000 15 Corn Syrup 18.175 Sodium Lauroyl Sarcosinate 0.075 Sodium Tartrate 0.250 Flavor 1.500 /The amorphous silica ingredient possesses the following characteristics: APS
Mean ''alue = 8.2 microns; oil absorption = 106 cc/100g; BE = 3.3; PE = 10.
Claims (14)
1. An amorphous silica abrasive composition, comprising:
a.) a precipitated silica, comprising particles wherein said particles have:
i.) a mean particle size of from 5 to 11 microns (s.d.<9);
ii.) an Einlehner hardness of from 0.8 to 2.5 for abrasive to brass screen and from 5 to 8 for abrasive to polyester screen;
iii.) an oil absorption of from 95 ml/100 gm to 135 ml/100 gm;
and iv.) a radioactive dentin abrasion of from 25 to 90;
and b.) a gel silica, comprising particles wherein said particles have:
i.) a mean particle size of from 5 to 11 microns (s.d.<9);
ii.) an Einlehner hardness of from 3 to 15 for abrasive to brass screen and from 8 to 20 for abrasive to polyester screen;
iii.) an oil absorption of from 60 ml/100 gm to 130 ml/100 gm;
and iv.) a radioactive dentin abrasion of from 80 to 200 wherein at least 70% of all of said particles have a diameter of below 25 microns and wherein the pellicle cleaning ratio is from 90 to 135, and the radioactive dentin abrasion is from 60 to 100, with a pellicle cleaning ratio/radioactive dentin abrasion ratio of from 1.20 to 1.60, and wherein the ratio of precipitated silica to gel silica is from 90:10 to 60:40, respectively.
a.) a precipitated silica, comprising particles wherein said particles have:
i.) a mean particle size of from 5 to 11 microns (s.d.<9);
ii.) an Einlehner hardness of from 0.8 to 2.5 for abrasive to brass screen and from 5 to 8 for abrasive to polyester screen;
iii.) an oil absorption of from 95 ml/100 gm to 135 ml/100 gm;
and iv.) a radioactive dentin abrasion of from 25 to 90;
and b.) a gel silica, comprising particles wherein said particles have:
i.) a mean particle size of from 5 to 11 microns (s.d.<9);
ii.) an Einlehner hardness of from 3 to 15 for abrasive to brass screen and from 8 to 20 for abrasive to polyester screen;
iii.) an oil absorption of from 60 ml/100 gm to 130 ml/100 gm;
and iv.) a radioactive dentin abrasion of from 80 to 200 wherein at least 70% of all of said particles have a diameter of below 25 microns and wherein the pellicle cleaning ratio is from 90 to 135, and the radioactive dentin abrasion is from 60 to 100, with a pellicle cleaning ratio/radioactive dentin abrasion ratio of from 1.20 to 1.60, and wherein the ratio of precipitated silica to gel silica is from 90:10 to 60:40, respectively.
2. An amorphous silica abrasive composition according to Claim 1, wherein the pellicle cleaning ratio is from 110 to 135.
3. An amorphous silica abrasive composition according to Claim 1, wherein the radioactive dentin abrasion is from 65 to 85.
4. An amorphous silica abrasive composition according to Claim 1, wherein the pellicle cleaning ratio/radioactive dentin abrasion ratio is from 1.25 to 1.50 and the ratio of precipitated silica to gel silica is from 80:20 to 60:40.
5. An amorphous silica abrasive composition according to Claim 1, wherein the pellicle cleaning ratio is from 90 to 135, the radioactive enamel abrasion is from 2.5 to 5, and wherein the pellicle cleaning ratio/radioactive enamel abrasion ratio of said amorphous silica abrasive composition is greater than 30.
6. An amorphous silica abrasive composition according to Claim 1, wherein the pellicle cleaning ratio is from 110 to 135, the radioactive enamel abrasion is from 2.5 to 3.5 and wherein the pellicle cleaning ratio/radioactive enamel abrasion ratio of said amorphous silica abrasive composition is from 35 to 44.
7. A dentifrice composition, comprising:
A.) from 0.1% to 99% of an amorphous silica abrasive composition, comprising:
a.) a precipitated silica, comprising particles wherein said particles have:
i.) a mean particle size of from 5 to 11 microns (s.d.<9);
ii.) an Einlehner hardness of from 0.8 to 2.5 for abrasive to brass screen and from 5 to 8 for abrasive to polyester screen;
iii.) an oil absorption of from 95 ml/100 gm to 135 ml/100 gm; and iv.) a radioactive dentin abrasion of from 25 to 90;
and b.) a gel silica, comprising particles wherein said particles have:
i.) a mean particle size of from 5 to 11 microns (s.d.<9);
ii.) an Einlehner hardness of from 3 to 15 for abrasive to brass screen and from 8 to 20 for abrasive to polyester screen;
iii.) an oil absorption of from 130 ml/100 gm to 60 ml/100 gm; and iv.) a radioactive dentin abrasion of from 80 to 200 wherein at least 70% of said particles have a diameter of below 25 microns and wherein the pellicle cleaning ration is from 90 to 135 and the radioactive dentin abrasion is from 60 to 100 with a pellicle cleaning ratio/radioactive dentin abrasion ratio of from 1.20 to 1.60 and wherein the ratio of precipitated silica to gel silica is from 90:10 to 60:40, respectively;
and B.) from 0.1% to 99% of an orally-acceptable dentifrice carrier.
A.) from 0.1% to 99% of an amorphous silica abrasive composition, comprising:
a.) a precipitated silica, comprising particles wherein said particles have:
i.) a mean particle size of from 5 to 11 microns (s.d.<9);
ii.) an Einlehner hardness of from 0.8 to 2.5 for abrasive to brass screen and from 5 to 8 for abrasive to polyester screen;
iii.) an oil absorption of from 95 ml/100 gm to 135 ml/100 gm; and iv.) a radioactive dentin abrasion of from 25 to 90;
and b.) a gel silica, comprising particles wherein said particles have:
i.) a mean particle size of from 5 to 11 microns (s.d.<9);
ii.) an Einlehner hardness of from 3 to 15 for abrasive to brass screen and from 8 to 20 for abrasive to polyester screen;
iii.) an oil absorption of from 130 ml/100 gm to 60 ml/100 gm; and iv.) a radioactive dentin abrasion of from 80 to 200 wherein at least 70% of said particles have a diameter of below 25 microns and wherein the pellicle cleaning ration is from 90 to 135 and the radioactive dentin abrasion is from 60 to 100 with a pellicle cleaning ratio/radioactive dentin abrasion ratio of from 1.20 to 1.60 and wherein the ratio of precipitated silica to gel silica is from 90:10 to 60:40, respectively;
and B.) from 0.1% to 99% of an orally-acceptable dentifrice carrier.
8. A dentifrice composition according to any one of the Claims 1 to 7, wherein said composition further comprises a fluoride ion source wherein the fluoride ion source is selected from the group consisting of sodium fluoride, stannous fluoride, sodium monofluorophosphate, potassium fluoride and mixtures thereof.
9. A dentifrice composition according to any one of the Claims 1 to 8, further comprising a surfactant selected from the group consisting of sarcosinate surfactants, isethionate surfactants and taurate surfactants.
10. A dentifrice composition according to any one of the Claims 1 to 9, further comprising from 0.1% to 2.5% of a chelating agent selected from the group consisting of tartaric acid and pharmaceutically-acceptable salts thereof, citric acid and alkali metal citrates and mixtures thereof.
11. A dentifrice composition according to any one of the Claims 1 to 10, wherein said composition has a pH above 7 and wherein the surfactant is selected from the group consisting of sodium lauroyl sarcosinate, sodium decyl sarcosinate, sodium myristyl sarcosinate, sodium stearyl sarcosinate, sodium palmitoyl sarcosinate, sodium oleoyl sarcosinate and mixtures thereof.
12. A dentifrice composition according to any one of the Claims 1 to 11, further comprising from 15% to 70% of a humectant selected from among the group consisting of glycerin, sorbitol, propylene glycol and mixtures thereof.
13. A dentifrice composition according to any one of the Claims 1 to 12, wherein the surfactant is a combination of sodium lauroyl sarcosinate and cocoamidopropyl betaine and the chelating agent is a combination of tartaric acid and sodium tartrate.
14. A dentifrice composition according to any one of the Claims 1 to 13, in the form of a toothpaste, tooth powder, prophylaxis paste, lozenge, gum, or oral gel.
Applications Claiming Priority (3)
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US434,154 | 1989-11-13 | ||
US08/434,154 US5658553A (en) | 1995-05-02 | 1995-05-02 | Dentifrice compositions |
PCT/US1996/005497 WO1996034593A1 (en) | 1995-05-02 | 1996-04-19 | Dentifrice compositions |
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CA2220026A1 CA2220026A1 (en) | 1996-11-07 |
CA2220026C true CA2220026C (en) | 2001-09-11 |
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EP (1) | EP0825847B1 (en) |
JP (1) | JPH11504919A (en) |
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CA (1) | CA2220026C (en) |
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PE (1) | PE3598A1 (en) |
PT (1) | PT825847E (en) |
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- 1996-04-19 AT AT96911814T patent/ATE197894T1/en not_active IP Right Cessation
- 1996-04-19 WO PCT/US1996/005497 patent/WO1996034593A1/en not_active Application Discontinuation
- 1996-04-19 PT PT96911814T patent/PT825847E/en unknown
- 1996-04-19 DE DE69611165T patent/DE69611165T2/en not_active Revoked
- 1996-04-19 EP EP96911814A patent/EP0825847B1/en not_active Revoked
- 1996-04-19 AU AU54879/96A patent/AU5487996A/en not_active Abandoned
- 1996-04-19 DK DK96911814T patent/DK0825847T3/en active
- 1996-04-19 MX MX9708433A patent/MX9708433A/en unknown
- 1996-04-19 CA CA002220026A patent/CA2220026C/en not_active Expired - Fee Related
- 1996-04-19 ES ES96911814T patent/ES2152520T3/en not_active Expired - Lifetime
- 1996-04-30 CO CO96021331A patent/CO4750635A1/en unknown
- 1996-05-02 PE PE1996000304A patent/PE3598A1/en not_active Application Discontinuation
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2000
- 2000-11-08 GR GR20000402485T patent/GR3034792T3/en not_active IP Right Cessation
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US5658553A (en) | 1997-08-19 |
ATE197894T1 (en) | 2000-12-15 |
AU5487996A (en) | 1996-11-21 |
CO4750635A1 (en) | 1999-03-31 |
CA2220026A1 (en) | 1996-11-07 |
GR3034792T3 (en) | 2001-02-28 |
DE69611165T2 (en) | 2001-07-19 |
PT825847E (en) | 2001-04-30 |
EP0825847A1 (en) | 1998-03-04 |
DE69611165D1 (en) | 2001-01-11 |
EP0825847B1 (en) | 2000-12-06 |
JPH11504919A (en) | 1999-05-11 |
WO1996034593A1 (en) | 1996-11-07 |
DK0825847T3 (en) | 2000-12-27 |
PE3598A1 (en) | 1998-03-27 |
ES2152520T3 (en) | 2001-02-01 |
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