CA2219342A1 - Antimicrobial impregnated catheters and medical implants and method for impregnating the same - Google Patents

Antimicrobial impregnated catheters and medical implants and method for impregnating the same

Info

Publication number
CA2219342A1
CA2219342A1 CA002219342A CA2219342A CA2219342A1 CA 2219342 A1 CA2219342 A1 CA 2219342A1 CA 002219342 A CA002219342 A CA 002219342A CA 2219342 A CA2219342 A CA 2219342A CA 2219342 A1 CA2219342 A1 CA 2219342A1
Authority
CA
Canada
Prior art keywords
medical implant
impregnating
antimicrobial
group
metallic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002219342A
Other languages
French (fr)
Other versions
CA2219342C (en
Inventor
Rabih O. Darouiche
Issam Raad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
University of Texas System
Original Assignee
Baylor College Of Medicine
Rabih O. Darouiche
Issam Raad
Board Of Regents, The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College Of Medicine, Rabih O. Darouiche, Issam Raad, Board Of Regents, The University Of Texas System filed Critical Baylor College Of Medicine
Publication of CA2219342A1 publication Critical patent/CA2219342A1/en
Application granted granted Critical
Publication of CA2219342C publication Critical patent/CA2219342C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/26—Penis implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections

Abstract

A non-metallic antimicrobial impregnated medical implant, such as a catheter, and a method for impregnating a non-metallic medical implant with an antimicrobial agent is provided. The method for making the impregnated implant comprises the steps of forming an antimicrobial composition of an effective concentration to inhibit the growth of organisms, such as staphylococci, other gram-positive bacteria, gram-negative bacilli and Candida and applying the antimicrobial composition to at least a portion of the medical implant under conditions where the antimicrobial composition permeates the material of the medical implant. The antimicrobial composition is formed by dissolving an antimicrobial agent in an organic solvent, adding a penetrating agent to the composition, and adding an alkalinizing agent to the composition. The antimicrobial composition is preferably heated to a temperature between about 30 ~C and 70 ~C prior to applying the composition to the medical implant to enhance the adherence of the antimicrobial agent to the medical implant material. After the impregnated implant is removed from the antimicrobial solution, the impregnated implant is allowed to dry, then rinsed with a liquid and milked to remove excess granular deposits and ensure uniform color of the impregnated implant.

Claims (52)

1. A method for impregnating a non-metallic implant with an antimicrobial agent comprising the steps of:

forming an antimicrobial composition of an effective concentration to inhibit the growth of bacterial and fungal organisms relative to uncoated implants by Dissolving the antimicrobial agent in a organic solvent , adding a penetrating agent to the composition;
adding an alkalinizing agent to the composition;and applying the antimicrobial composition to at least a portion of medical implant under conditions where the antimicrobial composition permeates the matorial of the medical implant.
2. The method for impregnating a non-metallic medical implant according to claim 1 , wherein the alkalinizing agent is selected is select from the group consisting of sodium hydroxide,potassium hydroxide,ammonis in water,diethylamine,and triethylamine.
3. The method for impregnating a non-metallic medical implant according to claim 1 ,wherein the alkalinizing agent comprises sodium hydroxide.
4. The method for impregnating a non-metallic medical implant according to claim 1,further comprising the step of heating the solution.
5. The method for impregnating a non-metallic medical implant according to claim 4, wherein the solution is heated to a temperature between about 30°C and 70°C.
6. The method for impregnating a non-metallic medical implant according to claim 1, wherein the step of applying the antimicrobial composition to the medical implant comprises dipping the implant in the composition for a period ofbetween 15 and 120 minutes, and removing the impregnated medical implant from the antimicrobial composition.
7. The method for impregnating a non-metallic medical implant according to claim 6, wherein the medical implant is dipped in the solution for a period of approximately 60 minutes.
8. The method for impregnating a non-metallic medical implant according to claim 1, further comprising the steps of rinsing with a liquid and milking the impregnated medical implant.
9. The method for impregnating a non-metallic medical implant according to claim 1, wherein the bacterial and fungal organisms are selected from the group consisting of gram-positive bacteria, gram-negative bacilli and Candida.
10. The method for impregnating a non-metallic medical implant according to claim 1, wherein the organic solvent is selected from the group consisting of alcohols, ketones, ethers, aldehydes, acetonitrile, acetic acid, methylene chloride and chloroform.
11. The method for impregnating a non-metallic medical implant according to claim 10, wherein the organic solvent is methanol.
12. The method for impregnating a non-metallic medical implant according to claim 1, wherein the penetrating agent is selected from the group consisting of esters, ketones, methylene chloride and chloroform.
13. The method for impregnating a non-metallic medical implant according to claim 12, wherein the penetrating agent is an ester selected from the group consisting of butyl acetate, ethyl acetate, propyl acetate, amyl acetate and combinations thereof.
14. The method for impregnating a non-metallic medical implant according to claim 1, wherein the step of forming an antimicrobial composition further comprises adding a salt exhibiting a high ionic strength.
15. The method for impregnating a non-metallic medical implant according to claim 1, wherein the medical implant is made from a material selected from the group consisting of silicone, polyurethane, polyethylene, polytetrafluoroethylene, polyethylene tetraphthalate and polyethylene tetraphthalate sealed with gelatin,collagen or albumin.
16. The method for impregnating a non-metallic medical implant according to claim 1, wherein the medical implant is a vascular catheter selected from the group consisting of peripherally insertable central venous catheters, dialysis catheters, long term tunneled central venous catheters, peripheral venous catheters, short-term central venous catheters, arterial catheters and pulmonaryartery Swan-Ganz catheters.
17. The method for impregnating a non-metallic medical implant according to claim 1, wherein the medical implant is a urinary catheter.
18. The method for impregnating a non-metallic medical implant according to claim 1, wherein the medical implant is a vascular graft.
19. The method for impregnating a non-metallic medical implant according to claim 1, wherein the medical implant is selected from the group consisting of vascular catheter ports, wound drain tubes, hydrocephalus shunts, peritoneal dialysis catheters,pecemaker capsules, artificial urinary sphincters, small or temporary joint replacements, urinary dilators, long term urinary devices, tissue bonding urinary devices, penile prostheses and heart valves.
20. The method for impregnating a non-metallic medical implant according to claim 1, wherein the antimicrobial agent is selected from the group consisting of antibiotics, antiseptics, disinfectants and synthetic moieties.
21.The method of impregnating a non-metallic medical implant according to claim 20,wherein the antimicrobial agent is an antibiotic selected from the group consisting of tetracyclines,penicillins,macrolides,rifampin and combinations thereof.
22. The method for impregnating a non-metallic medical implant according to claim 20,wherein the antimicrobial agent is an antibiotic comprising a combination of minocycline and rifampin.
23. The method for impregnating a non-metallic medical implant according to claim 20,wherein the antimicrobial agent is an antiseptic comprising hexachiorophene.
24. A method for impregnating a catheter formed of a polymeric material whith an antimicrobial agent comprising the steps of:
forming an antimicrobial solution of an effective concentration to inhibit the growth of bacterial and fungal organisms relative to uncoated implants by dissolving an alkalinizing agent selected from the group consisting of sodium hydroxide and potassium hydroxide in methanol,dissolving minocycline and rifampin in the solutoin,adding a penetrating agent selected from the group consisting of butyl acetate,ethyl acetate and combinations thereof to the solution;
heating the antimicrobial solution to a temperature of between about 30°C
and 70°C;

dipping at least a portion of the catheter in said antimicrobial solution under conditions where the antimicrobial solution permeates the polymeric material of the catheter ; and removing the catheter from the solution.
25. The method for impregnating a catheter according to claim 24, wherein the polymeric material is selected from the group consisting of rubber, plastic, silicone, polyurethane, polyethylene, polytetrefluoroethylone, polyethylenetetraphthalate and polyethylene tetraphthalate sealed with galatin, collagan or albumin.
26. The method for impregnating a catheter according to claim 24, wherein the bacterial and fungal organisms are selected from the group consisying of gram-positive bacteria, gram-negative bacilli and Candida.
27. A method for impregnating a catheter formed of a polymeric material with an antimicrobial agent comprising the steps of:
forming an antimicrobial solution of an effective concentration to inhibit the growth of bacterial and fungal organisms relative to uncoated implants by dissolving an alkalinizing agent selected from the group consisting of sodium hydroxide and potassium hydroxide in methanol, dissolving minocycline and rifampin in the solution , adding methylene chloride to the solution:
heating the antimicrobial solution to a temperature of between about 30°C
and 70°C;

dipping at least a portion of the catheter in said antimicrobial solution under condition wherein the antimicrobial solution permeates the polymeric material of the catheter;and removing the catheter from solution.
28. The method for impregnating a catheter according to claim 27,wherein the polymeric material is selected from the group consisting of silicone,polyurethane, polythylene,polytetrafluoroethylene,polyethylene tetraphalate and polyethylene teraphthalate sealed with gelatin,collagen or albumin.
29. The method for impregnating a catheter according to claim 27, wherein the bacterial and fungal organisms are selected from the group consisting of gram-positive bacteria,gram-negative bacilli and Candida.
30. An implantable medical device comprising:
a medical implant comprising a non-metallic material; and an antimicrobial composition,of an effective concentration to inhibit the growth of bacterial an fungal organisms,coating the surface of the implant and impregnating the non-metallic material of the medical implant;
wherein the antimicrobial composition comprises a mixture of an antimicrobial agent,an organic solvent and a penetrating agent.
31. The implantable medical device according to claim 30, wherein the bacterial and fungal organisms are selected from the group consisting of staphylococci, other gram-positive bacteria, gram-negative bacilli and Candida.
32.The implantable medical device according to claim 30,wherein the non-metallic material is selected from the group consisting of rubber,plastic, silicone, polyethylene tetraphthalate sealed with gelatin,collagen or albumin.
33. The implantable medical device according to claim 30, wherein the antimicrobial composition comprises a mixture of an antimicrobial agent , an organic solvent and a penetrating agent .
34. The implantable medical device according to claim 30 , wherein the organic solvent is selected from the group consisting alcohols,ketones , ethers,aldehydes, acetonitrile ,acetic acid , methylene chloride and chloroform.
35. The implantable medical device according to claim 34,wherein the organic solvent is methanol.
36. The implantable medical device according to claim 30, wherein the penetrating agent is select from the group consisting of esters,ketones,methylene chloride and chloroform.
37. The implantable medical device according to claim 36,wherein the penetrating agent is an ester selected from the group consisting of butyl acetate, ethyl acetate,propyl acetate, amyl acetate and combinations thereof.
38. The implantable medical device according to claim 30, wherein the mixture further comprises an alkalinizing agent.
39. The implantable medical device according to claim 38,wherein the alkalinizing agent is select from the group consisting of sodium hydroxide, potassium hydroxide,ammonia in water,diethylamine,and triethylamine.
40. The implantable medical device according to claim 38, wherein the alkalinizing agent comprises sodium hydroxide.
41. The implantable medical device according to claim 30, wherein the mixture further comprises a salt exhibiting a high ionic strength.
42. The implantable medical device according to claim 30, wherein the antimicrobial agent is selected from the group consisting of antibiotics,antiseptics, disinfectants and synthetic moeities.
43. The implantable medical device according to claim 42, wherein the antimicrobial agent is an antibiotic selected from the group consisting of tatracyclines, penicillins ,macrolides,rifampin and combinations thereof.
44. The implantable medical device according to claim 42,wherein the antimicrobial agent antibiotic comprising a combination of minocycline and rifampin.
45. The implantable medical device according to claim 42, wherein the antimicrobial agent is an antiseptic comprising hexachlorophene.
46. The implantable medical device according to claim 30, wherein the medical implant is a urinary catheter.
47. The implantable medical device according to claim 30, wherein the medical implant is a vascular catheter selected from the group consisting of peripherally insertable central venous catheters, dialysis catheters, long term tunneled central venous catheters, peripheral venous catheters, short-term central venous catheters, arterial catheters and pulmonary artery Swan-Ganz catheters.
48. The implantable medical device according claim 30, wherein the medical implant is a vascular graft.
49. The implantable medical device according to claim 30, wherein the medical implant is selected from the group consisting of vascular catheter ports, wound drain tubes, hydrocephalus shunts, peritoneal dialysis catheters, pacemaker capsules, artificial urinary sphincters, small or temporary joint replacements, urinary dilators, long term urinary devices, tissue bonding urinary devices, penile prostheses and heart valves.
50. The method for impregnating a non-metallic medical implant according to claim 1, wherein the medical implant is made from rubber or plastic.
51. The method for impregnating a catheter according to claim 25 or 28, wherein the medical implant is made from rubber or plastic.
52. The method for impregnating an implantable medical device according to claim 30, wherein the medical implant is made of rubber or plastic.
CA2219342A 1995-04-24 1996-04-22 Antimicrobial impregnated catheters and medical implants and method for impregnating the same Expired - Lifetime CA2219342C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/427,379 1995-04-24
US08/427,379 US5624704A (en) 1995-04-24 1995-04-24 Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
PCT/US1996/005776 WO1996033670A1 (en) 1995-04-24 1996-04-22 Antimicrobial impregnated catheters and medical implants and method for impregnating the same

Publications (2)

Publication Number Publication Date
CA2219342A1 true CA2219342A1 (en) 1996-10-31
CA2219342C CA2219342C (en) 2010-10-26

Family

ID=23694621

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2219342A Expired - Lifetime CA2219342C (en) 1995-04-24 1996-04-22 Antimicrobial impregnated catheters and medical implants and method for impregnating the same

Country Status (8)

Country Link
US (2) US5624704A (en)
EP (1) EP0830107B1 (en)
JP (2) JPH11504241A (en)
AU (1) AU705163B2 (en)
CA (1) CA2219342C (en)
DE (1) DE69633177T2 (en)
ES (1) ES2248809T3 (en)
WO (1) WO1996033670A1 (en)

Families Citing this family (255)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6468649B1 (en) * 1995-02-22 2002-10-22 Scimed Life Systems, Inc. Antimicrobial adhesion surface
US6558798B2 (en) 1995-02-22 2003-05-06 Scimed Life Systems, Inc. Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity
US7846202B2 (en) * 1995-06-07 2010-12-07 Cook Incorporated Coated implantable medical device
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US20070203520A1 (en) * 1995-06-07 2007-08-30 Dennis Griffin Endovascular filter
US7867275B2 (en) * 1995-06-07 2011-01-11 Cook Incorporated Coated implantable medical device method
US7550005B2 (en) * 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US7896914B2 (en) * 1995-06-07 2011-03-01 Cook Incorporated Coated implantable medical device
US5756145A (en) * 1995-11-08 1998-05-26 Baylor College Of Medicine Durable, Resilient and effective antimicrobial coating for medical devices and method of coating therefor
US6558686B1 (en) * 1995-11-08 2003-05-06 Baylor College Of Medicine Method of coating medical devices with a combination of antiseptics and antiseptic coating therefor
FR2743496B1 (en) * 1996-01-15 1998-04-10 Univ Rennes MACROPOROUS COMPOSITE SUPPORT FOR DRUG SUBSTANCE (S) FOR USE AS BONE RECONSTRUCTION MATERIAL AND PROCESS FOR PREPARING THE SAME
US20070161967A1 (en) * 1996-06-04 2007-07-12 Vance Products Inc., Dba Cook Urological Inc. Implantable medical device with pharmacologically active ingredient
US20040068241A1 (en) * 1996-06-04 2004-04-08 Fischer Frank J. Implantable medical device
US20060025726A1 (en) * 1996-06-04 2006-02-02 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with pharmacologically active layer
DE69714994T2 (en) * 1996-06-04 2003-04-30 Cook Inc IMPLANTABLE MEDICAL DEVICE
US20060030826A1 (en) * 1996-06-04 2006-02-09 Vance Products Incorporated,d/b/a Cook Urological Incorporated Implantable medical device with anti-neoplastic drug
US20060052757A1 (en) * 1996-06-04 2006-03-09 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with analgesic or anesthetic
US6800278B1 (en) 1996-10-28 2004-10-05 Ballard Medical Products, Inc. Inherently antimicrobial quaternary amine hydrogel wound dressings
US6039940A (en) * 1996-10-28 2000-03-21 Ballard Medical Products Inherently antimicrobial quaternary amine hydrogel wound dressings
DE19751132C2 (en) * 1997-11-19 2000-04-06 Udo Dunzendorfer Surface coated catheter
US6146688A (en) 1997-12-23 2000-11-14 Morgan; Harry C. Method of creating a biostatic agent using interpenetrating network polymers
DE19812160C1 (en) * 1998-03-20 1999-07-08 Bayer Ag Polyurethane articles containing antibiotic
US6129757A (en) * 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
AUPP437698A0 (en) 1998-06-30 1998-07-23 Baumgart, Karl Methods for treatment of coronary, carotid and other vascular disease
EP0985413A1 (en) * 1998-08-06 2000-03-15 Jörg Michael Dr. Dr. Schierholz Medical articles with sustained pharmacological activity and process for their preparation
DE59913045D1 (en) * 1998-08-06 2006-04-06 Schierholz Joerg Michael MEDICAL DEVICES WITH RETARDED PHARMACOLOGICAL ACTIVITY AND METHOD FOR THE PRODUCTION THEREOF
EP1115289A2 (en) 1998-09-23 2001-07-18 Phycogen, Inc. Environmentally benign crop protection agents
US6596401B1 (en) 1998-11-10 2003-07-22 C. R. Bard Inc. Silane copolymer compositions containing active agents
US6720415B2 (en) * 1998-12-02 2004-04-13 Princeton University Compositions and methods for regulating bacterial pathogenesis
US7326542B2 (en) * 1998-12-02 2008-02-05 Princeton University Compositions and methods for regulating bacterial pathogenesis
US6475434B1 (en) * 1998-12-07 2002-11-05 Baylor College Of Medicine Composition and methods for preventing and removing biofilm embedded microorganisms from the surface of medical devices
US6528107B2 (en) 1999-01-19 2003-03-04 Sulzer Carbomedics Inc. Method for producing antimicrobial antithrombogenic medical devices
US7081133B2 (en) * 1999-01-19 2006-07-25 Carbomedics Inc. Antibiotic treated implantable medical devices
US6416549B1 (en) 1999-07-19 2002-07-09 Sulzer Carbomedics Inc. Antithrombogenic annuloplasty ring having a biodegradable insert
US6416548B2 (en) 1999-07-20 2002-07-09 Sulzer Carbomedics Inc. Antimicrobial annuloplasty ring having a biodegradable insert
US6685694B2 (en) * 1999-07-23 2004-02-03 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6579539B2 (en) 1999-12-22 2003-06-17 C. R. Bard, Inc. Dual mode antimicrobial compositions
JP2003532698A (en) 2000-05-10 2003-11-05 プリンストン ユニバーシティ Compounds and methods for regulating bacterial growth and pathogenesis
AU2001261496A1 (en) * 2000-05-10 2001-11-20 Princeton University Luxo-sigma54 interactions and methods of use
WO2001095876A1 (en) * 2000-06-09 2001-12-20 Baylor College Of Medicine The combination of antimicrobial agents and bacterial interference to coat medical devices
US6562898B2 (en) * 2000-07-05 2003-05-13 Katsuhisa Masumoto Resin composition and manufacturing method therefor
US6534112B1 (en) * 2000-08-01 2003-03-18 Ams Research Corporation Semi-automatic coating system methods for coating medical devices
US6585677B2 (en) 2000-08-30 2003-07-01 John A. Cowan, Jr. Shunt
US7025063B2 (en) 2000-09-07 2006-04-11 Ams Research Corporation Coated sling material
US6592515B2 (en) 2000-09-07 2003-07-15 Ams Research Corporation Implantable article and method
US20040151765A1 (en) * 2001-09-18 2004-08-05 Ritchie Branson W. Methods and compositions for wound management
US20020091074A1 (en) * 2000-09-20 2002-07-11 Wooley Richard E. Medical compositions, dressings and methods for treating microbial infections of skin lesions
US20070003508A1 (en) 2005-07-01 2007-01-04 Wooley Richard E Methods and compositions for promoting wound healing
US20040208842A1 (en) * 2001-09-18 2004-10-21 Ritchie Branson W. Antimicrobial cleansing compositions and methods of use
US6588425B2 (en) 2000-12-21 2003-07-08 Kimberly-Clark Worldwide, Inc. Respiratory suction catheter apparatus with antimicrobial chamber
US7329412B2 (en) * 2000-12-22 2008-02-12 The Trustees Of Columbia University In The City Of New York Antimicrobial medical devices containing chlorhexidine free base and salt
CA2434254C (en) * 2001-01-12 2013-08-13 Board Of Regents, The University Of Texas System Novel antiseptic derivatives with broad spectrum antimicrobial activity for the impregnation of surfaces
US6582719B2 (en) * 2001-02-02 2003-06-24 The Trustees Of Columbia University In The City Of New York Combinations of antiseptic and antibiotic agents that inhibit the development of resistant microorganisms
WO2002065946A1 (en) * 2001-02-23 2002-08-29 Angiogene Inc. Apparatus for loading a therapeutic agent onto an endovascular device
WO2002069893A2 (en) * 2001-03-02 2002-09-12 Neuron Therapeutics, Inc. Treatment of neurological disease
DE10115740A1 (en) * 2001-03-26 2002-10-02 Ulrich Speck Preparation for restenosis prophylaxis
US7520897B2 (en) * 2001-04-11 2009-04-21 Helix Medical, Llc Medical devices having antimicrobial properties
US8317861B2 (en) * 2001-04-11 2012-11-27 Helix Medical, Llc Antimicrobial indwelling voice prosthesis
US7393547B2 (en) * 2001-04-11 2008-07-01 Helix Medical, Llc Antimicrobial elastomer composition and method for making
US20040092890A1 (en) * 2001-05-10 2004-05-13 Ash Stephen R. Catheter lock solution including a photo-oxidant
US20050215978A1 (en) * 2001-05-25 2005-09-29 Ash Stephen R Method of enhancing catheter patency using a citrate salt catheter lock solution
US20030065292A1 (en) * 2001-06-08 2003-04-03 Darouiche Rabih O. Ozonated medical devices and methods of using ozone to prevent complications from indwelling medical devices
US6589591B1 (en) * 2001-07-10 2003-07-08 Baylor College Of Medicine Method for treating medical devices using glycerol and an antimicrobial agent
IS6390A (en) * 2001-08-31 2003-03-03 Heraeus Kulzer Gmbh & Co. Kg Experiences of antibiotic coating of carcasses containing microspheres, thus coated carcasses and also of their use
US20070173460A1 (en) * 2001-09-20 2007-07-26 Oculus Innovative Sciences, Inc. Compositions comprising lignin and methods of making and using the same
US6981977B2 (en) * 2001-10-26 2006-01-03 Atrium Medical Corporation Body fluid cartridge exchange platform device
US6716200B2 (en) 2002-01-18 2004-04-06 C.R. Bard, Inc. Antimicrobial urine collection system and methods of manufacturing the same
CA2473355C (en) * 2002-01-18 2012-01-03 Michael E. Snyder Sustained release ophthalmological device and method of making and using the same
RU2314831C2 (en) * 2002-01-22 2008-01-20 Фармация Энд Апджон Компани Infection-proof medical devices
US20050192547A1 (en) * 2002-01-31 2005-09-01 Modak Shanta M. Combinations of antiseptic and antibiotic agents containing medical devices
US8133501B2 (en) 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
US8685427B2 (en) * 2002-07-31 2014-04-01 Boston Scientific Scimed, Inc. Controlled drug delivery
US7993390B2 (en) * 2002-02-08 2011-08-09 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US6887270B2 (en) * 2002-02-08 2005-05-03 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US8506647B2 (en) * 2002-02-14 2013-08-13 Boston Scientific Scimed, Inc. System for maintaining body canal patency
GB0207021D0 (en) * 2002-03-25 2002-05-08 Univ Warwick Anti-bacterial agents
US8313760B2 (en) * 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
PT1509256E (en) * 2002-05-24 2009-10-15 Angiotech Int Ag Compositions and methods for coating medical implants
DK1521603T3 (en) 2002-07-12 2011-04-18 Cook Inc Coated medical device
US8920826B2 (en) * 2002-07-31 2014-12-30 Boston Scientific Scimed, Inc. Medical imaging reference devices
DE10242476B4 (en) * 2002-09-11 2006-10-26 Heraeus Kulzer Gmbh Antibiotic / antibiotics-polymer combination
DE10244847A1 (en) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medical device for drug delivery
US6819951B2 (en) 2002-09-24 2004-11-16 Mayo Foundation For Medical Education And Research Peripherally inserted central catheter with continuous central venous oximetry and proximal high flow port
US20050008763A1 (en) * 2002-09-24 2005-01-13 Schachter Steven C. Antimicrobial coatings for medical applications
US9597067B2 (en) 2002-10-04 2017-03-21 Ethicon, Inc. Packaged antimicrobial medical device and method of preparing same
US7513093B2 (en) * 2002-10-04 2009-04-07 Ethicon, Inc. Method of preparing a packaged antimicrobial medical device
US20050101993A1 (en) * 2002-10-04 2005-05-12 Howard Scalzo Antimicrobial packaged medical device and method of preparing same
US8133437B2 (en) 2002-10-04 2012-03-13 Ethicon, Inc. Method of preparing an antimicrobial packaged medical device
US9474524B2 (en) 2002-10-04 2016-10-25 Ethicon, Inc. Packaged antimicrobial medical device having improved shelf life and method of preparing same
US20040068293A1 (en) * 2002-10-04 2004-04-08 Howard Scalzo Packaged antimicrobial medical device and method of preparing same
US8112973B2 (en) 2002-10-04 2012-02-14 Ethicon, Inc. Method of making a packaged antimicrobial suture
US20040220614A1 (en) * 2002-10-04 2004-11-04 Howard Scalzo Packaged antimicrobial medical device and method of preparing same
US20050079365A1 (en) * 2002-10-09 2005-04-14 Widenhouse Christopher W. Method for the surface modification of silicone surfaces
US20040115477A1 (en) * 2002-12-12 2004-06-17 Bruce Nesbitt Coating reinforcing underlayment and method of manufacturing same
US20040186528A1 (en) * 2003-03-20 2004-09-23 Medtronic, Inc. Subcutaneous implantable medical devices with anti-microbial agents for chronic release
US8404269B2 (en) * 2003-04-11 2013-03-26 Michael Snyder Sustained release implantable eye device
US7306580B2 (en) * 2003-04-16 2007-12-11 Cook Incorporated Medical device with therapeutic agents
US20040256561A1 (en) * 2003-06-17 2004-12-23 Allyson Beuhler Wide band light sensing pixel array
AU2004251823B2 (en) * 2003-06-19 2010-06-03 Janssen Pharmaceutica N.V. Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists
US6996952B2 (en) * 2003-09-30 2006-02-14 Codman & Shurtleff, Inc. Method for improving stability and effectivity of a drug-device combination product
WO2005037338A1 (en) * 2003-10-14 2005-04-28 Cook Incorporated Hydrophilic coated medical device
CA2536188A1 (en) * 2003-11-20 2005-06-09 Angiotech International Ag Electrical devices and anti-scarring agents
WO2005061003A1 (en) * 2003-12-12 2005-07-07 Medtronic, Inc. Anti-infective medical device
US8691258B2 (en) * 2003-12-12 2014-04-08 Medtronic, Inc. Anti-infective medical device
US20050197634A1 (en) * 2004-01-20 2005-09-08 Board Of Regents, The University Of Texas System Methods for coating and impregnating medical devices with antiseptic compositions
WO2005091967A2 (en) * 2004-03-03 2005-10-06 University Of Georgia Research Foundation, Inc. Methods and compositions for ophthalmic treatment of fungal and bacterial infections
WO2005096990A2 (en) * 2004-04-02 2005-10-20 Baylor College Of Medicine Novel modification of medical prostheses
EP2255832A3 (en) * 2004-06-16 2011-02-09 Affinergy, Inc. IFBM's to promote attachment of target analytes
BRPI0512222A (en) * 2004-06-18 2008-02-19 Boc Group Inc antimicrobial coating for gas cylinders and coupling components
US7794490B2 (en) * 2004-06-22 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices with antimicrobial and biodegradable matrices
EP1809349B1 (en) * 2004-07-05 2009-10-14 Ziscoat N.V. Biocompatible coating of medical devices comprising molecular sieves
US20060009839A1 (en) * 2004-07-12 2006-01-12 Scimed Life Systems, Inc. Composite vascular graft including bioactive agent coating and biodegradable sheath
US20060020328A1 (en) * 2004-07-23 2006-01-26 Tan Sharon M L Composite vascular graft having bioactive agent
US20060039946A1 (en) * 2004-08-20 2006-02-23 Medtronic Inc. Drug eluting medical device
US20060058737A1 (en) * 2004-09-16 2006-03-16 Herweck Steve A Catheter treatment stylet
GB0421164D0 (en) * 2004-09-23 2004-10-27 Univ Nottingham Medical devices and methods of making medical devices
US20060116636A1 (en) * 2004-11-30 2006-06-01 Murphy Kieran P Self-sealing catheter for deformable tissue
US20060126751A1 (en) * 2004-12-10 2006-06-15 Anthony Bessios Technique for disparity bounding coding in a multi-level signaling system
US7749529B2 (en) 2005-02-08 2010-07-06 Ash Access Technology, Inc. Catheter lock solution comprising citrate and a paraben
AU2005100176A4 (en) * 2005-03-01 2005-04-07 Gym Tv Pty Ltd Garbage bin clip
CN101146558B (en) * 2005-03-03 2012-11-07 科维蒂恩股份公司 Medical treatment device and its making method
MX2007011771A (en) * 2005-03-22 2008-03-14 Biosafe Inc Method of creating a solvent-free polymeric silicon-containing quaternary ammonium antimicrobial agent having superior sustained antimicrobial properties.
US20070048249A1 (en) 2005-08-24 2007-03-01 Purdue Research Foundation Hydrophilized bactericidal polymers
US20070093894A1 (en) * 2005-10-25 2007-04-26 Baylor College Of Medicine Incorporation of antimicrobial combinations onto devices to reduce infection
US20070213835A1 (en) * 2005-11-04 2007-09-13 Markus Wimmer Plastic implant impregnated with an antibiotic
WO2007062306A2 (en) * 2005-11-18 2007-05-31 The Board Of Regents Of The University Of Texas System Methods for coating surfaces with antimicrobial agents
US20070134287A1 (en) * 2005-12-09 2007-06-14 Biomet Manufacturing Corp Method for coating biocompatible substrates with antibiotics
US8591531B2 (en) 2006-02-08 2013-11-26 Tyrx, Inc. Mesh pouches for implantable medical devices
WO2009113972A2 (en) 2006-02-08 2009-09-17 Tyrx Pharma, Inc. Temporarily stiffened mesh prostheses
US20080033371A1 (en) * 2006-06-26 2008-02-07 Updegraff Debra K Cover for catheter assembly
US7981128B2 (en) 2006-06-30 2011-07-19 Atheromed, Inc. Atherectomy devices and methods
US20090018566A1 (en) 2006-06-30 2009-01-15 Artheromed, Inc. Atherectomy devices, systems, and methods
US8361094B2 (en) 2006-06-30 2013-01-29 Atheromed, Inc. Atherectomy devices and methods
EP2037821B1 (en) 2006-06-30 2022-06-22 Atheromed, Inc. Atherectomy devices
US8298564B2 (en) * 2006-09-27 2012-10-30 Medtronic, Inc. Two part antimicrobial boot
US20080075628A1 (en) * 2006-09-27 2008-03-27 Medtronic, Inc. Sterilized minocycline and rifampin-containing medical device
US20080082038A1 (en) * 2006-09-28 2008-04-03 Vance Products Incorporated, D/B/A/ Cook Urological Incorporated Medical Device including a Bioactive in a Non-ionic and an Ionic Form and Methods of Preparation Thereof
US20080081829A1 (en) * 2006-09-28 2008-04-03 Med Institute, Inc Medical Device Including an Anesthetic and Method of Preparation Thereof
US20080108824A1 (en) * 2006-09-28 2008-05-08 Med Institute, Inc Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices
JP5161452B2 (en) 2006-10-03 2013-03-13 日本コヴィディエン株式会社 Method for manufacturing medical device, method for applying antibiotic to surface of medical device, and medical device
US9023114B2 (en) * 2006-11-06 2015-05-05 Tyrx, Inc. Resorbable pouches for implantable medical devices
US20100136072A1 (en) * 2006-11-08 2010-06-03 Massachusetts Institute Of Technology Polymeric Coatings that Inactivate Viruses and Bacteria
DE102006062111A1 (en) 2006-12-23 2008-06-26 Farco-Pharma Gmbh Composition, in particular for blocking catheters
US20080228139A1 (en) * 2007-02-06 2008-09-18 Cook Incorporated Angioplasty Balloon With Concealed Wires
US8323307B2 (en) * 2007-02-13 2012-12-04 Cook Medical Technologies Llc Balloon catheter with dilating elements
US8573218B2 (en) 2007-03-07 2013-11-05 Michael John RUTTER Tracheostomy tube
WO2008112592A1 (en) * 2007-03-09 2008-09-18 Anthem Orthopaedics Llc Implantable medicament delivery device and delivery tool and method for use therewith
EP2136855A2 (en) * 2007-03-20 2009-12-30 Boston Scientific Scimed, Inc. Urological medical devices for release of prostatically beneficial therapeutic agents
WO2008121750A2 (en) * 2007-03-28 2008-10-09 Vance Products Incorporated D/B/A Medical device for delivering a bioactive and method of use thereof
CA2682190C (en) * 2007-03-29 2015-01-27 Tyrx Pharma, Inc. Biodegradable, polymer coverings for breast implants
TW200901890A (en) * 2007-04-03 2009-01-16 Sure Internat Ventures B V New compostions and methods for cell killing
US8430852B2 (en) * 2007-04-17 2013-04-30 Medtronic, Inc. Therapeutic sleeve for implantable medical device
EP2144640B1 (en) * 2007-04-17 2012-03-28 Medtronic, Inc. Reduction of infection associated with medical device
US20080300610A1 (en) 2007-05-31 2008-12-04 Cook Incorporated Device for treating hardened lesions and method of use thereof
US9981069B2 (en) 2007-06-20 2018-05-29 The Trustees Of Columbia University In The City Of New York Bio-film resistant surfaces
EP2018864A1 (en) 2007-07-23 2009-01-28 Biomet Deutschland GmbH Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition
US20090041727A1 (en) * 2007-08-08 2009-02-12 Conjugon, Inc. Compositions and Methods for Microbe Storage and Delivery
WO2009032605A2 (en) * 2007-08-27 2009-03-12 Massachusetts Institute Of Technology Bi-functional polymer-attached inhibitors of influenza virus
US8637455B2 (en) * 2007-10-22 2014-01-28 Affinergy, Llc Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces
US8070762B2 (en) 2007-10-22 2011-12-06 Atheromed Inc. Atherectomy devices and methods
US20090171283A1 (en) * 2007-12-27 2009-07-02 Cook Incorporated Method of bonding a dilation element to a surface of an angioplasty balloon
US20090171284A1 (en) * 2007-12-27 2009-07-02 Cook Incorporated Dilation system
US8211165B1 (en) 2008-01-08 2012-07-03 Cook Medical Technologies Llc Implantable device for placement in a vessel having a variable size
US8053020B2 (en) * 2008-02-28 2011-11-08 Cook Medical Technologies Llc Process for coating a portion of an implantable medical device
US8192675B2 (en) 2008-03-13 2012-06-05 Cook Medical Technologies Llc Cutting balloon with connector and dilation element
US9034365B2 (en) 2008-05-20 2015-05-19 Poly-Med, Inc. Biostable, multipurpose, microbicidal intravaginal devices
US8389583B2 (en) 2008-05-23 2013-03-05 Zurex Pharma, Inc. Antimicrobial compositions and methods of use
DE102008026207B4 (en) * 2008-05-30 2015-01-15 Manouchehr Abdolali Coating agent for coating a surface of a medical implant
WO2010036427A1 (en) 2008-06-17 2010-04-01 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
US20100010521A1 (en) * 2008-07-10 2010-01-14 Cook Incorporated Cutting balloon with movable member
US7939488B2 (en) 2008-08-26 2011-05-10 The Clorox Company Natural disinfecting cleaners
BRPI0918540A2 (en) * 2008-09-11 2015-12-08 Bacterin Int Inc method for impregnating a polymer, and bioactive metal impregnated polymer
US8420153B2 (en) * 2008-09-19 2013-04-16 Mentor Worldwide Llc Coating with antimicrobial agents
US8419793B2 (en) * 2008-09-19 2013-04-16 Mentor Worldwide Llc Coating with antimicrobial agents
US8445008B2 (en) * 2008-10-17 2013-05-21 Medtronic, Inc. Reduction of infection associated with medical device
WO2010051506A1 (en) 2008-10-31 2010-05-06 Alure Medical, Inc. Minimally invasive tissue support system and method with a superior tissue support and an inferior anchor
US8640643B2 (en) * 2008-12-26 2014-02-04 Ams Research Corporation Method for controlling drug loading in a medical device
US20100203100A1 (en) * 2009-02-02 2010-08-12 Medtronic, Inc. Antimicrobial accessory for an implantable medical device
JP2010187910A (en) * 2009-02-18 2010-09-02 Nippon Sherwood Medical Industries Ltd Antibacterial medical device and manufacturing method thereof
GB2480791B (en) 2009-03-20 2014-11-05 Univ Texas Method for imparting antimicrobial activity to a medical device
US8209016B2 (en) * 2009-03-20 2012-06-26 Medtronic, Inc. Implantable lead management
US20100249783A1 (en) * 2009-03-24 2010-09-30 Warsaw Orthopedic, Inc. Drug-eluting implant cover
US20100247600A1 (en) * 2009-03-24 2010-09-30 Warsaw Orthopedic, Inc. Therapeutic drug eluting implant cover and method of making the same
US8092443B2 (en) 2009-03-30 2012-01-10 Medtronic, Inc. Element for implantation with medical device
WO2010120620A1 (en) 2009-04-13 2010-10-21 Cook Incorporated Coated balloon catheter
US9078712B2 (en) * 2009-04-15 2015-07-14 Warsaw Orthopedic, Inc. Preformed drug-eluting device to be affixed to an anterior spinal plate
US9414864B2 (en) * 2009-04-15 2016-08-16 Warsaw Orthopedic, Inc. Anterior spinal plate with preformed drug-eluting device affixed thereto
US8858983B2 (en) * 2009-04-30 2014-10-14 Medtronic, Inc. Antioxidants and antimicrobial accessories including antioxidants
EP2475406B1 (en) * 2009-09-09 2015-10-21 Cook Medical Technologies LLC Methods of manufacturing drug-loaded substrates
US20110066141A1 (en) * 2009-09-11 2011-03-17 Cook Incorporated Implantable medical device having an anti-gastric distress agent
US9006278B2 (en) * 2010-02-02 2015-04-14 Poly-Med, Inc. Controlled release systems of pluribioactive antifungal drugs and applications thereof
WO2011118680A1 (en) * 2010-03-26 2011-09-29 テルモ株式会社 Process for production of antimicrobial medical instrument, and antimicrobial medical instrument
US9308298B2 (en) * 2010-03-30 2016-04-12 Medcatheters, Inc. Drug releasing medical catheters, tubes, and devices
DE102010020940B4 (en) * 2010-05-19 2014-09-25 Heraeus Medical Gmbh Antibiotic coating
US8951577B2 (en) 2010-08-03 2015-02-10 Teleflex Medical Incorporated Antimicrobial hydrochloric acid catheter lock solution and method of use
SE535732C2 (en) 2010-09-17 2012-11-27 Nanexa Ab Polymeric product with protective layer that prevents the ingrowth of fungi or other microbial substances
GB201021186D0 (en) * 2010-12-14 2011-01-26 Novabiotics Ltd Composition
AU2010254599B1 (en) * 2010-12-15 2011-02-17 Cook Incorporated Hybrid Type A dissection device
US8911427B2 (en) 2010-12-28 2014-12-16 Medtronic, Inc. Therapeutic agent reservoir delivery system
US20120208744A1 (en) * 2011-02-16 2012-08-16 The Penn State Research Foundation Anti-microbial agents and compositions and methods of production and use thereof
JP2014516604A (en) 2011-03-24 2014-07-17 シー・アール・バード・インコーポレーテッド Immobilization and protection of implanted medical devices
WO2012137166A1 (en) 2011-04-07 2012-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. An oxoborolidine compound and uses thereof
WO2012137164A1 (en) 2011-04-07 2012-10-11 Biolinerx Ltd. Antimicrobial compositions, antibiofilm compositions and uses thereof
WO2013013221A1 (en) 2011-07-20 2013-01-24 Brigham Young University Hydrophobic ceragenin compounds and devices incorporating same
US20140302113A1 (en) * 2011-09-30 2014-10-09 Sparkmed Research, Llc Systems, devices, and methods for embedding drug molecules into medical catheters or tubes
US20140296706A1 (en) 2011-10-19 2014-10-02 Interperc Technologies, Llc Devices to Support, Measure and Characterize Luminal Structures
US10245025B2 (en) 2012-04-06 2019-04-02 Ethicon, Inc. Packaged antimicrobial medical device having improved shelf life and method of preparing same
CA2872399C (en) 2012-05-02 2021-01-12 Brigham Young University Ceragenin particulate materials and methods for making same
ES2729968T3 (en) 2012-08-08 2019-11-07 Univ Texas Antimicrobial compositions comprising glyceryl nitrates
CA2889981A1 (en) 2012-10-29 2014-05-08 Ariste Medical, Inc. Polymer coating compositions and coated products
US9943529B2 (en) 2013-01-07 2018-04-17 Brigham Young University Methods for reducing cellular proliferation and treating certain diseases
WO2014137454A1 (en) 2013-03-07 2014-09-12 Tyrx, Inc. Methods and compositions to inhibit the assemblage of microbial cells irreversibly associated with surfaces of medical devices
AU2014249274B2 (en) * 2013-03-11 2016-11-24 Teleflex Medical Incorporated Devices with anti-thrombogenic and anti-microbial treatment
US9320592B2 (en) 2013-03-15 2016-04-26 Covidien Lp Coated medical devices and methods of making and using same
US9545301B2 (en) 2013-03-15 2017-01-17 Covidien Lp Coated medical devices and methods of making and using same
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
DK2967967T3 (en) * 2013-03-15 2019-12-09 Donald Griffith Systems and methods for zones of microbial resistance
JP6518230B2 (en) 2013-03-15 2019-05-22 ブリガム・ヤング・ユニバーシティＢｒｉｇｈａｍ Ｙｏｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ Methods of treating inflammation, autoimmune disease, and pain
US10568893B2 (en) 2013-03-15 2020-02-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
EP2986342B1 (en) * 2013-04-18 2020-08-19 Board of Regents, The University of Texas System Antimicrobial catheters
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US9668890B2 (en) 2013-11-22 2017-06-06 Covidien Lp Anti-thrombogenic medical devices and methods
US10286190B2 (en) 2013-12-11 2019-05-14 Cook Medical Technologies Llc Balloon catheter with dynamic vessel engaging member
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
EP2898920B1 (en) 2014-01-24 2018-06-06 Cook Medical Technologies LLC Articulating balloon catheter
CN106029156A (en) 2014-02-21 2016-10-12 阿瓦蒂姆技术股份有限公司 Method for maintenance of urethral catheters
CA2844321C (en) 2014-02-27 2021-03-16 Brigham Young University Cationic steroidal antimicrobial compounds
US10220045B2 (en) 2014-03-13 2019-03-05 Brigham Young University Compositions and methods for forming stabilized compositions with reduced CSA agglomeration
US9931350B2 (en) 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
WO2015164524A1 (en) 2014-04-22 2015-10-29 Ariste Medical, Inc. Methods and processes for application of drug delivery polymeric coatings
US10441595B2 (en) 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10227376B2 (en) 2014-08-22 2019-03-12 Brigham Young University Radiolabeled cationic steroid antimicrobials and diagnostic methods
US10155788B2 (en) 2014-10-07 2018-12-18 Brigham Young University Cationic steroidal antimicrobial prodrug compositions and uses thereof
CA2968525A1 (en) 2014-11-19 2016-05-26 Avadim Technologies, Inc. Method for the prevention and treatment of acne
US9789228B2 (en) 2014-12-11 2017-10-17 Covidien Lp Antimicrobial coatings for medical devices and processes for preparing such coatings
US10149956B2 (en) 2015-02-28 2018-12-11 John P. Ure Bi-lateral endobronchial suctioning device and medical suctioning system for intubated patients
US10370403B2 (en) 2015-04-22 2019-08-06 Brigham Young University Methods for the synthesis of ceragenins
US20170080128A1 (en) * 2015-09-21 2017-03-23 Brigham Young University Novel endotracheal tube for the reduction of intubation-related complication in neonates and babies
ES2951010T3 (en) 2016-02-01 2023-10-17 Schierholz Joerg Michael Implantable health products, procedure for their preparation and use thereof
WO2017147067A1 (en) 2016-02-22 2017-08-31 Board Of Regents, The University Of Texas System Antimicrobial compositions and uses thereof
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
RU2620161C1 (en) * 2016-07-26 2017-05-23 Акционерное общество "Медсил" Method for manufacture of bypass system catheter with antimicrobial properties for hydrocephalia treatment
CA3049919A1 (en) 2016-12-22 2018-06-28 Wiab Water Innovation Ab Preparations for controlled-release of hypochlorous acid
CN106730044B (en) * 2016-12-28 2020-07-07 创领心律管理医疗器械（上海）有限公司 Antibacterial hydrogel bag and preparation method thereof
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
US20180340046A1 (en) 2017-05-27 2018-11-29 Poly Group LLC Dispersible antimicrobial complex and coatings therefrom
EP3638740A1 (en) 2017-06-16 2020-04-22 Poly Group LLC Polymeric antimicrobial surfactant
IL258467A (en) 2018-03-29 2018-07-04 Ilana Kolodkin Gal Methods of disrupting a biofilm and/or preventing formation of same
CO2018009806A1 (en) * 2018-09-18 2019-03-18 Gomez William Gomez William System and device for infection prevention and measurement of body fluids
KR20220027800A (en) 2018-11-02 2022-03-08 더블유아이에이비 워터 이노베이션 에이비 Compositions and methods for treating transient biofilms
KR20220027799A (en) 2018-11-02 2022-03-08 더블유아이에이비 워터 이노베이션 에이비 Compositions for treating biofilms without inducing antimicrobial resistance
US11304723B1 (en) 2020-12-17 2022-04-19 Avantec Vascular Corporation Atherectomy devices that are self-driving with controlled deflection
WO2023014730A1 (en) * 2021-08-03 2023-02-09 Mcglynn Patrick Subcutaneous tunneling catheter for peritoneal access

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598127A (en) * 1968-06-06 1971-08-10 James G Wepsic Catheter having antibacterial substance therein provided with means permitting slow release of said substance
US3566874A (en) * 1968-08-13 1971-03-02 Nat Patent Dev Corp Catheter
US3695921A (en) * 1970-09-09 1972-10-03 Nat Patent Dev Corp Method of coating a catheter
FR2498813A1 (en) * 1981-01-27 1982-07-30 Instruments Sa EQUIPMENT TREATMENT FACILITY FOR SEMICONDUCTOR PRODUCTION
DE3272706D1 (en) * 1981-05-27 1986-09-25 Unitika Ltd Urethral catheter capable of preventing urinary tract infection and process for producing the same
US4603152A (en) * 1982-11-05 1986-07-29 Baxter Travenol Laboratories, Inc. Antimicrobial compositions
US4592920A (en) * 1983-05-20 1986-06-03 Baxter Travenol Laboratories, Inc. Method for the production of an antimicrobial catheter
US4605564A (en) * 1984-01-23 1986-08-12 Biological & Environmental Control Laboratories, Inc. Coating process for making antimicrobial medical implant device
US4842575A (en) * 1984-01-30 1989-06-27 Meadox Medicals, Inc. Method for forming impregnated synthetic vascular grafts
US4581028A (en) * 1984-04-30 1986-04-08 The Trustees Of Columbia University In The City Of New York Infection-resistant materials and method of making same through use of sulfonamides
US4723950A (en) * 1984-12-12 1988-02-09 C. R. Bard, Inc. Urine drainage bag outlet with barrier against microbial infection
US4612337A (en) * 1985-05-30 1986-09-16 The Trustees Of Columbia University In The City Of New York Method for preparing infection-resistant materials
US4917686A (en) * 1985-12-16 1990-04-17 Colorado Biomedical, Inc. Antimicrobial device and method
US4895566A (en) * 1986-07-25 1990-01-23 C. R. Bard, Inc. Coating medical devices with cationic antibiotics
US4803256A (en) * 1988-02-01 1989-02-07 Dow Corning Corporation Method of altering the surface of a solid synthetic polymer
US5019096A (en) * 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US4865870A (en) * 1988-07-07 1989-09-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic
US4925668A (en) * 1989-01-18 1990-05-15 Becton, Dickinson And Company Anti-infective and lubricious medical articles and method for their preparation
US5013306A (en) * 1989-01-18 1991-05-07 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US5165952A (en) * 1989-01-18 1992-11-24 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US4999210A (en) * 1989-01-18 1991-03-12 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US5069899A (en) * 1989-11-02 1991-12-03 Sterilization Technical Services, Inc. Anti-thrombogenic, anti-microbial compositions containing heparin
US5142010A (en) * 1990-05-10 1992-08-25 H. B. Fuller Licensing & Financing Inc. Polymeric biocidal agents
WO1991017724A1 (en) * 1990-05-17 1991-11-28 Harbor Medical Devices, Inc. Medical device polymer
US5344411A (en) * 1991-02-27 1994-09-06 Leonard Bloom Method and device for inhibiting HIV, hepatitis B and other viruses and germs when using a catheter in a medical environment
JPH0564660A (en) * 1991-05-21 1993-03-19 Sumitomo Bakelite Co Ltd Medical catheter and making thereof
WO1993006881A1 (en) * 1991-10-10 1993-04-15 Menlo Care, Inc. Therapeutic agent in hydrophilic matrix
US5217493A (en) * 1992-03-11 1993-06-08 Board Of Regents, The University Of Texas System Antibacterial coated medical implants
DE4216271A1 (en) * 1992-05-16 1993-11-18 Siegel Rolf Process for the wet chemical surface modification of moldings made of organopolysiloxanes and use of the process products
DE4226810C1 (en) * 1992-08-13 1994-01-27 Theodor Dipl Ing Krall Hoses and other objects made of plastic for medical use, which are not colonized by germs and processes for their manufacture
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5362754A (en) * 1992-11-12 1994-11-08 Univ. Of Tx Md Anderson Cancer Center M-EDTA pharmaceutical preparations and uses thereof
US5494765A (en) * 1993-01-14 1996-02-27 Mita Industrial Co. Ltd Electrophotosensitive material using a phenylenediamine derivative

Also Published As

Publication number Publication date
EP0830107A1 (en) 1998-03-25
ES2248809T3 (en) 2006-03-16
JPH11504241A (en) 1999-04-20
EP0830107B1 (en) 2004-08-18
AU705163B2 (en) 1999-05-20
JP4630238B2 (en) 2011-02-09
CA2219342C (en) 2010-10-26
DE69633177D1 (en) 2004-09-23
AU5575696A (en) 1996-11-18
EP0830107A4 (en) 2000-10-25
JP2006305375A (en) 2006-11-09
WO1996033670A1 (en) 1996-10-31
US5624704A (en) 1997-04-29
US5902283A (en) 1999-05-11
DE69633177T2 (en) 2005-08-11

Similar Documents

Publication Publication Date Title
CA2219342A1 (en) Antimicrobial impregnated catheters and medical implants and method for impregnating the same
US5567495A (en) Infection resistant medical devices
US6162487A (en) Method of coating medical devices with a combination of antiseptics and antiseptic coating therefor
Riedl et al. Heparin coating reduces encrustation of ureteral stents: a preliminary report
US6475434B1 (en) Composition and methods for preventing and removing biofilm embedded microorganisms from the surface of medical devices
JP4999842B2 (en) Antibacterial composition for inhibiting the growth and proliferation of microbial biofilms on medical devices
Jansen et al. Bacterial adherence to hydrophilic polymer–coated polyurethane stents
US4563485A (en) Injection-resistant materials and method of making same through use of nalidixic acid derivatives
EP1960013B1 (en) Methods for coating surfaces with antimicrobial agents
US4605564A (en) Coating process for making antimicrobial medical implant device
US6340465B1 (en) Lubricious coatings for medical devices
US6106505A (en) Triclosan-containing medical devices
US7087661B1 (en) Safe and effective biofilm inhibitory compounds and health-related uses thereof
US7314857B2 (en) Synergistic antimicrobial compositions and methods of inhibiting biofilm formation
US20060246208A1 (en) Method for treating medical devices using glycerol and an antimicrobial agent
JP2001500408A (en) EPTFE small diameter vascular grafts with significant patency enhancement via a surface coating containing covalent heparin
JPH03501691A (en) catheter
US9228996B2 (en) Method and device for detecting device colonization
WO2005018701A1 (en) Synergistic antimicrobial compositions and methods of inhibiting biofilm formation
JP2010508109A (en) Method for producing an implantable prosthesis from a base element made of a porous material, a prosthesis related thereto and use thereof
RU2462273C1 (en) Method for processing synthetic textile implanted blood contact medical devices
Lin et al. Antimicrobial activities of iodinated polystyrene derivatives
CA2452032C (en) Synergistic antimicrobial compositions and methods of inhibiting biofilm formation
AU767489B2 (en) Triclosan-containing medical devices
Busscher et al. Biomaterials Biocompatibility in Health Problems

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20160422