CA2218995A1 - Diagnostic detection device and method - Google Patents

Diagnostic detection device and method

Info

Publication number
CA2218995A1
CA2218995A1 CA002218995A CA2218995A CA2218995A1 CA 2218995 A1 CA2218995 A1 CA 2218995A1 CA 002218995 A CA002218995 A CA 002218995A CA 2218995 A CA2218995 A CA 2218995A CA 2218995 A1 CA2218995 A1 CA 2218995A1
Authority
CA
Canada
Prior art keywords
analyte
volume
liquid sample
casing
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002218995A
Other languages
French (fr)
Other versions
CA2218995C (en
Inventor
Albert Nazareth
Mary Beth Boyle
Yea-Shun Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armkel LLC
Original Assignee
Carter Wallace, Inc.
Albert Nazareth
Mary Beth Boyle
Yea-Shun Cheng
Medpointe Healthcare Inc.
Armkel Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carter Wallace, Inc., Albert Nazareth, Mary Beth Boyle, Yea-Shun Cheng, Medpointe Healthcare Inc., Armkel Llc filed Critical Carter Wallace, Inc.
Publication of CA2218995A1 publication Critical patent/CA2218995A1/en
Application granted granted Critical
Publication of CA2218995C publication Critical patent/CA2218995C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick

Abstract

The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing (10) defining a liquid sample inlet, a reservoir volume a test volume and a window (16) through the casing at the test volume. Disposed within the cell is a sample absorbent, a novel biphasic substrate and a reservoir, together capable of transporting an aqueous solution within the casing along a flow path extending from the sample inlet through the test volume and into the reservoir volume.
The invention further comprises a method for detecting the presence of an analyte in a liquid sample using the device and a biphasic chromatographic material for carrying out the method. The release medium is e.g. absorbent paper and holds a band of e.g. antibody-metal sol, and a band of e.g. antibody-biotin which bind to first and second epitopes respectively of the analyte.
The capture site is e.g. nitrocellulose or nylon, holding an immobilized capture component, e.g. streptavidin. A control site may be present. The release medium and capture site are joined by overlapping to form the chromatographic substrate.
CA002218995A 1995-05-02 1996-05-01 Diagnostic detection device and method Expired - Fee Related CA2218995C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/432,894 1995-05-02
US08/432,894 US6319676B1 (en) 1995-05-02 1995-05-02 Diagnostic detection device and method
PCT/US1996/006087 WO1996035123A1 (en) 1995-05-02 1996-05-01 Diagnostic detection device and method

Publications (2)

Publication Number Publication Date
CA2218995A1 true CA2218995A1 (en) 1996-11-07
CA2218995C CA2218995C (en) 2002-12-31

Family

ID=23718008

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002218995A Expired - Fee Related CA2218995C (en) 1995-05-02 1996-05-01 Diagnostic detection device and method

Country Status (9)

Country Link
US (4) US6319676B1 (en)
EP (1) EP0823972B1 (en)
JP (1) JPH10511774A (en)
AT (1) ATE251752T1 (en)
AU (1) AU709403B2 (en)
CA (1) CA2218995C (en)
DE (1) DE69630295T2 (en)
ES (1) ES2208746T3 (en)
WO (1) WO1996035123A1 (en)

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CA2218995C (en) 2002-12-31
US7045342B2 (en) 2006-05-16
US6319676B1 (en) 2001-11-20
EP0823972A1 (en) 1998-02-18
ATE251752T1 (en) 2003-10-15
JPH10511774A (en) 1998-11-10
WO1996035123A1 (en) 1996-11-07
AU709403B2 (en) 1999-08-26
ES2208746T3 (en) 2004-06-16
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US20010051350A1 (en) 2001-12-13
EP0823972B1 (en) 2003-10-08
DE69630295D1 (en) 2003-11-13
AU5852196A (en) 1996-11-21
MX9708428A (en) 1998-08-30
US6767714B2 (en) 2004-07-27
US20020042082A1 (en) 2002-04-11
US20040171174A1 (en) 2004-09-02

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