CA2218255A1 - Method of treatment using electroporation-mediated delivery of drugs and genes - Google Patents

Method of treatment using electroporation-mediated delivery of drugs and genes

Info

Publication number
CA2218255A1
CA2218255A1 CA002218255A CA2218255A CA2218255A1 CA 2218255 A1 CA2218255 A1 CA 2218255A1 CA 002218255 A CA002218255 A CA 002218255A CA 2218255 A CA2218255 A CA 2218255A CA 2218255 A1 CA2218255 A1 CA 2218255A1
Authority
CA
Canada
Prior art keywords
electroporation
treatment
genes
drugs
mediated delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002218255A
Other languages
French (fr)
Other versions
CA2218255C (en
Inventor
S. B. Dev
Gunter A. Hofmann
Richard A. Gilbert
Yasuhiko Hayakawa
Richard Heller
Mark J. Jaroszeski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetronics Inc
Original Assignee
Genetronics, Inc.
S. B. Dev
Gunter A. Hofmann
Richard A. Gilbert
Yasuhiko Hayakawa
Richard Heller
Mark J. Jaroszeski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/467,566 external-priority patent/US5702359A/en
Application filed by Genetronics, Inc., S. B. Dev, Gunter A. Hofmann, Richard A. Gilbert, Yasuhiko Hayakawa, Richard Heller, Mark J. Jaroszeski filed Critical Genetronics, Inc.
Publication of CA2218255A1 publication Critical patent/CA2218255A1/en
Application granted granted Critical
Publication of CA2218255C publication Critical patent/CA2218255C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion

Abstract

A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
CA002218255A 1995-06-06 1996-05-22 Method of treatment using electroporation-mediated delivery of drugs and genes Expired - Fee Related CA2218255C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/467,566 US5702359A (en) 1995-06-06 1995-06-06 Needle electrodes for mediated delivery of drugs and genes
US08/467,566 1995-06-06
US08/537,265 1995-09-29
US08/537,265 US5993434A (en) 1993-04-01 1995-09-29 Method of treatment using electroporation mediated delivery of drugs and genes
PCT/US1996/007470 WO1996039226A1 (en) 1995-06-06 1996-05-22 Method of treatment using electroporation-mediated delivery of drugs and genes

Publications (2)

Publication Number Publication Date
CA2218255A1 true CA2218255A1 (en) 1996-12-12
CA2218255C CA2218255C (en) 2001-11-20

Family

ID=27042102

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002218255A Expired - Fee Related CA2218255C (en) 1995-06-06 1996-05-22 Method of treatment using electroporation-mediated delivery of drugs and genes

Country Status (12)

Country Link
US (6) US5993434A (en)
EP (1) EP0874663B1 (en)
JP (1) JPH11506630A (en)
KR (1) KR100260238B1 (en)
CN (1) CN1150950C (en)
AT (1) ATE185083T1 (en)
AU (1) AU702054B2 (en)
CA (1) CA2218255C (en)
DE (1) DE69604509T2 (en)
ES (1) ES2140096T3 (en)
GR (1) GR3031963T3 (en)
WO (1) WO1996039226A1 (en)

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