CA2214488A1 - Determination of cpsa - Google Patents

Determination of cpsa

Info

Publication number
CA2214488A1
CA2214488A1 CA002214488A CA2214488A CA2214488A1 CA 2214488 A1 CA2214488 A1 CA 2214488A1 CA 002214488 A CA002214488 A CA 002214488A CA 2214488 A CA2214488 A CA 2214488A CA 2214488 A1 CA2214488 A1 CA 2214488A1
Authority
CA
Canada
Prior art keywords
fpsa
cpsa
antibody
specific
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002214488A
Other languages
French (fr)
Other versions
CA2214488C (en
Inventor
William Jeffrey Allard
Kwok K. Yeung
Zeqi Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2214488(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/903,750 external-priority patent/US5840501A/en
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of CA2214488A1 publication Critical patent/CA2214488A1/en
Application granted granted Critical
Publication of CA2214488C publication Critical patent/CA2214488C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Abstract

A method for determining the complexed forms of immunologically determinable prostate specific antigen (cPSA) in a blood sample, e.g., by two- site immunometric assays, in which the blood sample is treated to render free PSA (fPSA) immunologically nondetectable. A particularly preferred immunometric assay method employs three anti-PSA antibodies: an antibody that binds to both cPSA and fPSA (anti-tPSA), a second anti-tPSA antibody which is characterized by the unique property that binding to fPSA is blocked by binding of fPSA-specific antibodies, and a third antibody which is a fPSA-specific antibody. Thus, binding of the fPSA-specific antibody to PSA in the sample allows only cPSA to be measured in the immunometric assay. Measurement of cPSA blood levels has been found to provide a method for aiding in the diagnosis and monitoring of prostate cancer that is highly sensitive and specific, and eliminates the need for a significant number of patients to undergo unnecessary prostate biopsy.
CA002214488A 1996-10-25 1997-09-03 Determination of cpsa Expired - Fee Related CA2214488C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US73838396A 1996-10-25 1996-10-25
US738,383 1996-10-25
US83496997A 1997-04-07 1997-04-07
US834,969 1997-04-07
US08/903,750 1997-07-31
US08/903,750 US5840501A (en) 1996-10-25 1997-07-31 Determination of cPSA

Publications (2)

Publication Number Publication Date
CA2214488A1 true CA2214488A1 (en) 1998-04-25
CA2214488C CA2214488C (en) 2007-06-19

Family

ID=27419236

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002214488A Expired - Fee Related CA2214488C (en) 1996-10-25 1997-09-03 Determination of cpsa

Country Status (14)

Country Link
US (2) US5928878A (en)
EP (1) EP0838680B1 (en)
JP (1) JP4274330B2 (en)
AT (1) ATE267399T1 (en)
AU (1) AU746345B2 (en)
CA (1) CA2214488C (en)
CZ (1) CZ295854B6 (en)
DE (1) DE69729156T2 (en)
DK (1) DK0838680T3 (en)
ES (1) ES2221006T3 (en)
HU (1) HU221350B1 (en)
IL (1) IL121659A (en)
NO (1) NO974534L (en)
PT (1) PT838680E (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19641560A1 (en) * 1996-10-09 1998-04-16 Boehringer Mannheim Gmbh Monoclonal antibodies against a complex of human ACT and a serine protease
CA2243033A1 (en) * 1997-07-31 1999-01-31 Bayer Corporation Determination of psa-act
AU1682699A (en) * 1997-12-25 1999-07-19 Japan Tobacco Inc. Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
GB9827845D0 (en) * 1998-12-17 1999-02-10 Scolab S A Immunoassay or proteins
CA2311512A1 (en) * 1999-07-24 2001-01-24 Bayer Corporation Reflex method for the detection of prostate cancer
JP3536731B2 (en) * 1999-07-28 2004-06-14 富士レビオ株式会社 HIV-1 p24 antigen immunoassay method and reagent
US6569684B2 (en) 2000-01-06 2003-05-27 University Of Central Florida Method of identifying and treating invasive carcinomas
DE60107022T2 (en) 2000-07-24 2005-11-24 Health Research Inc. Method for the detection of prostate-specific membrane antigen in serum
US6379550B1 (en) 2000-07-24 2002-04-30 Health Research, Inc. Method for detecting PSA and its molecular forms using thiophilic gel
EP1307538B1 (en) * 2000-08-07 2009-01-07 Vanderbilt University Detection of cox-2 activity and anandamide metabolites
CA2422856C (en) * 2000-09-25 2012-02-07 Abbott Laboratories Methods and kits for decreasing interferences of assay samples containing plasma or serum in specific binding assays by using a large polycation
US6764825B1 (en) * 2000-10-13 2004-07-20 Tang J. Wang Methods and device for detecting prostate specific antigen (PSA)
US6838264B2 (en) * 2000-12-05 2005-01-04 Immutopics, Inc. Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84
US7226749B2 (en) * 2000-12-05 2007-06-05 Zahradnik Richard J Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84
ATE331958T1 (en) * 2002-03-13 2006-07-15 Biomerieux Sa METHOD FOR DETECTING AND QUANTIFYING CIRCULATIVE TUMOR CELLS ARISING FROM SOLID TUMORS
US20040018580A1 (en) * 2002-05-10 2004-01-29 Chai Karl X. Synthetic substrates for prostasin
US7666981B1 (en) 2002-05-10 2010-02-23 University Of Central Florida Research Foundation, Inc. Inhibitors of prostasin
US7314709B2 (en) * 2002-08-06 2008-01-01 Vanderbilt University Compositions and methods for detecting and quantifying COX-2 activity by lipoamino acid metabolism
EP1507147A1 (en) * 2003-08-12 2005-02-16 Erasmus University Medical Center Rotterdam Method for detecting low levels of a fusion protein
ATE412181T1 (en) * 2004-01-28 2008-11-15 Turun Yliopisto IMPROVED METHOD FOR DIAGNOSING ACUTE CORONARY SYNDROME
US8012694B2 (en) 2006-09-14 2011-09-06 Immutopics, Inc. Assay for the detection of phosphorylated PTH
EP2107377A1 (en) * 2008-04-04 2009-10-07 BRAHMS Aktiengesellschaft Pro-endothelin-1 levels for the prediction of risk of tachyarrhytmic events
WO2009124978A1 (en) * 2008-04-09 2009-10-15 Brahms Aktiengesellschaft Pro-endothelin-1 for the prediction of impaired peak oxygen consumption
US8632971B2 (en) 2011-11-08 2014-01-21 Caldera Health Limited Methods and materials for determining the efficacy of prostate cancer therapies
US20130116131A1 (en) 2011-11-08 2013-05-09 Caldera Health Limited Methods and materials for the diagnosis of prostate cancers
US8658164B2 (en) 2011-11-08 2014-02-25 Caldera Health Limited Methods and materials for the diagnosis of prostate cancers
US8658166B2 (en) 2011-11-08 2014-02-25 Caldera Health Limited Methods and materials for the diagnosis of prostate cancers
JP6604081B2 (en) * 2014-08-13 2019-11-13 東ソー株式会社 Method for measuring pancreatic ribonuclease 1 to which an N-type sugar chain is added

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0690203B2 (en) * 1985-08-23 1994-11-14 中外製薬株式会社 Method for quantifying prostate-specific antigen and α-lower 1-antitrypsin complex
SE9002480D0 (en) * 1990-07-23 1990-07-23 Hans Lilja ASSAY OF FREE AND COMPLEXED PROSTATE-SPECIFIC ANTIGEN
DE4322342A1 (en) * 1993-07-05 1995-02-09 Gif Ges Fuer Immunologische Fo Method for the differential diagnosis of carcinoma of the prostate
EP0635575A1 (en) * 1993-07-22 1995-01-25 Wallac Oy Monoclonal antibodies against epitopes found in free but not in alpha-1-antichmotrypsin complexed prostate specific antigen
US5599677A (en) * 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5698402A (en) * 1995-02-23 1997-12-16 Dianon Systems, Inc. Methods for diagnosing benign prostatic hyperplasia
US5710007A (en) * 1995-09-29 1998-01-20 Luderer; Albert A. Methods for diagnosing prostatic adenocarcinoma

Also Published As

Publication number Publication date
HUP9701717A2 (en) 1998-05-28
CA2214488C (en) 2007-06-19
IL121659A (en) 2000-07-16
NO974534L (en) 1998-04-27
ES2221006T3 (en) 2004-12-16
DE69729156T2 (en) 2005-05-25
US6107049A (en) 2000-08-22
AU3926797A (en) 1998-04-30
EP0838680A1 (en) 1998-04-29
IL121659A0 (en) 1998-02-22
CZ335797A3 (en) 1998-05-13
US5928878A (en) 1999-07-27
CZ295854B6 (en) 2005-11-16
HUP9701717A3 (en) 2000-04-28
JP4274330B2 (en) 2009-06-03
PT838680E (en) 2004-08-31
HU221350B1 (en) 2002-09-28
NO974534D0 (en) 1997-10-01
JPH10177027A (en) 1998-06-30
EP0838680B1 (en) 2004-05-19
ATE267399T1 (en) 2004-06-15
DK0838680T3 (en) 2004-09-27
AU746345B2 (en) 2002-04-18
DE69729156D1 (en) 2004-06-24
HU9701717D0 (en) 1997-12-29

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20160906