CA2213694A1 - Composite waveguide for solid phase binding assays - Google Patents

Composite waveguide for solid phase binding assays

Info

Publication number
CA2213694A1
CA2213694A1 CA002213694A CA2213694A CA2213694A1 CA 2213694 A1 CA2213694 A1 CA 2213694A1 CA 002213694 A CA002213694 A CA 002213694A CA 2213694 A CA2213694 A CA 2213694A CA 2213694 A1 CA2213694 A1 CA 2213694A1
Authority
CA
Canada
Prior art keywords
binding assays
solid phase
composite waveguide
phase binding
waveguide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002213694A
Other languages
French (fr)
Other versions
CA2213694C (en
Inventor
W. Monty Reichert
James N. Herron
Hsu-Kun Wang
Douglas A. Christensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
University Of Utah Research Foundation
W. Monty Reichert
James N. Herron
Hsu-Kun Wang
Douglas A. Christensen
University Of Utah
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Utah Research Foundation, W. Monty Reichert, James N. Herron, Hsu-Kun Wang, Douglas A. Christensen, University Of Utah, Duke University filed Critical University Of Utah Research Foundation
Publication of CA2213694A1 publication Critical patent/CA2213694A1/en
Application granted granted Critical
Publication of CA2213694C publication Critical patent/CA2213694C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes

Abstract

A step-gradient composite waveguide (100) for evanescent sensing in fluorescent binding assays comprises a thick substrate layer (102) having one or more thin film waveguide channels (104) deposited thereon.
CA002213694A 1995-02-23 1996-02-23 Composite waveguide for solid phase binding assays Expired - Lifetime CA2213694C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/393,450 1995-02-23
US08/393,450 US5814565A (en) 1995-02-23 1995-02-23 Integrated optic waveguide immunosensor
PCT/US1996/002662 WO1996026432A1 (en) 1995-02-23 1996-02-23 Composite waveguide for solid phase binding assays

Publications (2)

Publication Number Publication Date
CA2213694A1 true CA2213694A1 (en) 1996-08-29
CA2213694C CA2213694C (en) 2009-01-27

Family

ID=23554757

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002213694A Expired - Lifetime CA2213694C (en) 1995-02-23 1996-02-23 Composite waveguide for solid phase binding assays

Country Status (6)

Country Link
US (4) US5814565A (en)
EP (1) EP0812416A4 (en)
JP (1) JPH11500826A (en)
AU (1) AU693666B2 (en)
CA (1) CA2213694C (en)
WO (1) WO1996026432A1 (en)

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