CA2211512C - Aneurysm closure device assembly - Google Patents

Aneurysm closure device assembly Download PDF

Info

Publication number
CA2211512C
CA2211512C CA002211512A CA2211512A CA2211512C CA 2211512 C CA2211512 C CA 2211512C CA 002211512 A CA002211512 A CA 002211512A CA 2211512 A CA2211512 A CA 2211512A CA 2211512 C CA2211512 C CA 2211512C
Authority
CA
Canada
Prior art keywords
occlusion
lumen
retaining device
retaining
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002211512A
Other languages
French (fr)
Other versions
CA2211512A1 (en
Inventor
David Kupiecki
Clifford Teoh
Hong Doan
Son M. Gia
Erik T. Engelson
Uriel Hiram Chee
Mehran Bashiri
Joseph C. Eder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Target Therapeutics Inc
Original Assignee
Target Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Target Therapeutics Inc filed Critical Target Therapeutics Inc
Publication of CA2211512A1 publication Critical patent/CA2211512A1/en
Application granted granted Critical
Publication of CA2211512C publication Critical patent/CA2211512C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/88Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A61B17/12118Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm for positioning in conjunction with a stent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214Coils or wires
    • A61B17/12145Coils or wires having a pre-set deployed three-dimensional shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214Coils or wires
    • A61B17/12154Coils or wires having stretch limiting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • A61B2017/12054Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12063Details concerning the detachment of the occluding device from the introduction device electrolytically detachable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006Properties of materials and coating materials
    • A61F2002/30092Properties of materials and coating materials using shape memory or superelastic materials, e.g. nitinol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00023Titanium or titanium-based alloys, e.g. Ti-Ni alloys

Abstract

This is an artificial occlusion kit for implanting and retaining an artificial occlusion device in a body space adjacent to and extending from a body lumen in a mammal. The includes at least one occlusion device and a retaining device for blocking the migration of the occlusion device out of the occlusion site. The retaining device is radially expandable at a retaining site adjacent the body space to be occluded to a diameter that is sufficient to engage the body lumen wall at the retaining site and form a barrier across the entrance zone of the body space to be occluded. The expanded retaining device also forms a lumen for flow through body lumen at the retaining site. At least one semi-penetrable space may also beprovided in the retaining device, allowing introduction of occlusion devices into the body space to be occluded, but preventing subsequent migration of the occlusion devices out of the body space. This semi-penetrable space may also be distensible to allow for delivery of occlusion devices therethrough. An introducer wire or a tapered-tip delivery catheter may be used to distend the distensible space and deliver the occlusion devices. The retaining device structure may further include a radiopaque metal wire wound into a primary helix over an inner core member made of a superelastic alloy of nickel and titanium. An implantable medical device assembly is also provided, having the structure described for theretaining device of the novel artificial occlusion kit, and which is attached to an elongate pusher via a sacrificial link that is electrolytically dissolvable.

Description

ANEURYSM CLOSURF DEVICE ASSE1~'IBLY
FIELD OF THE INVENTION
This invention is an implantable medical device assembly for use in surgical procedures. The invention includes an artificial occlusion kit that uses a S retaining device to prevent migration of artificial occlusion implants from an occlusion site, such as an aneurysm, and into an adjacent body space, such as a blood vessel.
BACKGROUND OF THE INVENTION
Different implantable medical devices have been developed for treating various ailments associated with body lumens. such as ailments of body vessel walls or other lumenal walls. One category of implantable medical device that has been developed for artificial occlusion of body spaces is the category of "artificial occlusion devices." Although artificial occlusion devices are useful in occluding body spaces, other applications include occluding body lumens. Examples of lumens that have been identified as candidates for treatment with artificial occlusion devices include, for example, the vas deferens or the fallopian tubes.
Most commonly, however, artificial occlusion devices have been disclosed for medical treatment of the vascular lumens and aneurysms in the walls of such vessels. This treatment is commonly referred to as "artificial vaso-occlusion."
Artificial Vaso-occlusion Artificial vaso-occlusion is a medical treatment that has involved techniques such as the delivery of various occlusive agents including solidifying suspensions, thrombogenic fluids, or emboli such as hog hair or suspensions of metal particles. Delivery of such agents or emboli normally causes a thrombogenic or other occlusive tissue response. Recent advancements in artificial occlusion of vessels and aneurysms have included the delivery and implantation of metal coils. Implantable metal coils that are useful as artificial occlusion devices in vascular lumens or aneurysms are herein referred to as "vaso-occlusion coils."
Vaso-occlusion coils generally are constructed of a wire, usually made of a metal or metal alloy, that is wound into a helix. Vaso-occlusion coils are normally delivered through microcatheters such as the type disclosed in U.S.
Patent No. 4,739,768 to Engelson. The microcatheter commonly tracks a guide wire to a point just proximal of or within the desired site for occlusion. The coil is advanced through the microcatheter and out the distal end hole so to at least partially fill the selected space and create an occlusion.
Once a vaso-occlusion coil is implanted at a desired site, occlusion results either from the space-filling mechanism inherent in the coil itself, or from a cellular response to the coil such as a thrombus formation, or both. The space-filling mechanism of the vaso-occlusion coil may be either based upon a pre-determined secondary geometry, or may be based upon random flow characteristics of the coil as it is expelled from a delivery sheath lumen.
Vaso-occlusion coils have been disclosed that have a secondary geometry or shape which dictates at least in part their space-filling occlusion mechanism.
Such a secondary shape may include a secondary helical structure which involves the primary coil helix being itself wound into a second helix. In addition to the space-filling feature, another benefit to having a secondary coil shape is that it may allow the coil readily to anchor itself against the walls of a delivery site. For example, a vaso-occlusion coil having a secondary shape may be ejected from a
2~ sheath lumen where it was constrained in a stretched condition to have a first outer diameter equal to the sheath lumen inner diameter. When ejected, the coil passively expands to its secondary shape, often having a larger, second outer diameter to aid in space-filling the body cavity or lumen. This may be an expansion to the coil's relaxed. unrestrained memory state--or at least until the ;: ..

coil encounters a vessel wall against which it exerts a force to complete the anchoring process.
One example of a type of vaso-occlusion coil having a pre-determined secondary shape is described in US Patent No. 4,994,069 to Ritchart et al.
Ritchart describes a vaso-occlusive wire having a memory imparted thereto by heating the wire at about 800°F for 24 hours after it is shaped. This memory is effective to return the wire from a stretched, linear condition in which it is advanced through a catheter to a space-filling relaxed condition as the wire is released from the catheter. The diameter of the secondary shape is approximately equal to and may be larger than the vessel in which it is deployed.
In contrast to vaso-occlusion coils having pre-determined secondary shapes that dictate in part their space-filling mechanism, other vaso-occlusion coils have been disclosed that take on random shapes when expelled from a delivery sheath.
This type of vaso-occlusive coil is often referred to as the "liquid coil."
One example of such a vaso-occlusive coil which takes on a random occlusive shape when delivered into a body space is disclosed in pending U.S. Patent Application Serial No. 08/413,970, filed March 30, 1995 which corresponds in part to Canadian Patent Application No. 2,173, 023. This document describes very soft and flexible coils which are flow-injectable through the delivery catheter using, e.g., saline solution.
In addition to the various types of space-filling mechanisms and geometries of vaso-occlusion coils, other particularized features of coil designs, such as mechanisms for delivering vaso-occlusion coils through delivery catheters and implanting them in a desired occlusion site, have also been described.
Examples of categories of vaso-occlusion coils based upon their delivery mechanisms include pushable coils, mechanically detachable coils, and electrolytically detachable coils.
One example of the type of vaso-occlusion coil referred to as the "pushable coil" is disclosed in U.S. Patent No. 4,994,069 to Ritchart et al., introduced above. Pushable coils are commonly provided in a cartridge and are pushed or "plunged" from the cartridge into a delivery catheter lumen. A pusher rod advances the pushable coil through and out of the delivery catheter lumen and into the site for occlusion.
In contrast to pushable coils, mechanically detachable vaso-occlusion coils are integrated with a pusher rod and mechanically detached from the pusher after exiting a delivery chatheter. Examples of such mechanically detachable vaso-occlusion coils are provided in U.S. Patent No. 5,261,916 to Engelson, or U.S. Patent No. 5,250,071 to Palermo.
Further in contrast to the mechanically detachable type of vaso-occlusion coil, the electrolytically detachable type is also integrated with a pusher rod, but is detached from the pusher by applying a direct current that dissolves a sacrificial link between the pusher and the coil. Examples of such electrolyrically detachable vaso-occlusion coils are disclosed in U.S. Patent No.
5,122,136 to Guglielmi, et al. and U.S. Patent No. 5,354,295 to Guglielmi, et al.
A further improvement upon the electrolytic detachment mechanisms just previously referenced is disclosed in co-pending Canadian Application No.
2,162,117. This document describes superimposing an alternating current signal over the direct current signal, wherein a sensing circuit monitors the alternating current signal as an indicator of the progression of coil detachment.
Improvements for enhancing the thrombogenic or other occlusive tissue response to metal coils have also been disclosed. For example, vaso-occlusion coils having vaso-occlusive fibers attached thereto have been described (see for example, U.S. Patent No. 5,226,911 to Chee et al.). A further type of vaso-occlusion coil is used as a detachable dielectric electrode in .a radio-frequency artificial vaso-occlusion system, is disclosed in co-pending Canadian Application No. 2,182,738.

Vaso-occlusion Coils in Aneurysms A wide variety of clinical abnormalities in body lumens may be treated with artificial occlusion methods. For example, artificial occlusion methods have been disclosed for treating feeder vessels into tumors, arterio-venous malformations, fistulas, and aneurysms of vessel walls. Among arterial abnormalities, aneurysms present particular medical risk due to the dangers of potential rupture of the thinned wall inherent in an aneurysm. Occlusion of aneurysms with vaso-occlusion coils without occluding the adjacent artery is a desirable method of reducing such risk.
In one disclosed method of treating aneurysms with vaso-occlusion coils, a microcatheter is initially steered into or adjacent the entrance of an aneurysm, aided by a steerable wire. The wire is then withdrawn from the microcatheter lumen and replaced by the vaso-occlusion coil. The vaso-occlusion coil is advanced through and out of the microcatheter, desirably being completely delivered into the aneurysm. After or during delivery of such a coil into the aneurysm, a portion of the coil might then migrate out of the aneurysm entrance zone and into the feeding vessel. This may cause an undesirable response of occluding the feeding vessel. Also, there is an additional risk that the blood flow may induce movement of the coil farther out of the aneurysm, resulting in a more developed embolus in the good vessel.
One type of aneurysm, commonly referred to as a "wide-neck aneurysm,"
is known to present particular difficulty in placing and retaining vaso-occlusion coils. Wide-neck aneurysms are herein referred to as aneurysms of vessel walls having a neck or "entrance zone" from the adjacent vessel, which entrance zone has a diameter that either: ( 1 ) is at least 80% of the largest diameter of the aneurysm; or (2) is clinically observed to be too wide to effectively retain vaso-occlusion coils that are deployed using conventional techniques.
In attempting to prevent potential migration of vaso-occlusion coils from :0 aneurysms. catheter distal tip shapes may be formed on delivery microcatheters to help support the distal tip during deployment of vaso-occlusive agents.
However.
this may provide only a partial solution, particularly in the case of wide-neck aneurysms.
There is a need for a retaining device that is adapted to block an entrance S zone to an aneurysm such that occlusion devices may be implanted in and retained within the aneurysm and are prevented from migrating through the entrance zone of the aneurysm and into the adjacent vessel.
SUMMARY OF THE INV NTION
This invention is a novel artificial occlusion kit, which includes a novel I 0 implantable medical device useful for retaining occlusion devices at an occlusion site, and related method for use. A particularly useful application of the invention is in the treatment of wide-neck aneurysms and aneurysms emanating from a curving vessel..
An artificial occlusion kit is provided for implanting and retaining an 15 artificial occlusion device in a body space adjacent to and extending from a bode lumen in a mammal. The artificial occlusion kit has at least one occlusion device adapted for filling at least a portion of the body space, and a retaining device assembly that includes a retaining device.
The retaining device of the artificial occlusion kit is adapted to be 20 delivered and implanted at a retaining site in the body lumen adjacent to the body space to be occluded. This retaining device has a first shape that is radially expandable to a diameter that is sufficient to engage the wall of the body lumen at a retaining site adjacent the body space to be occluded. V~~hen engaged with the body lumen wall, the retaining device forms a lumen having a diameter that is 2~ sufficient to allow flow therethrough, and also forms a barrier that prevents occlusion devices that are implanted in the body space from migrating out of the body space and into the adjacent body lumen.
In one retaining device variation. the first shape is formed when the retaining device is radiallv constrained during delivery to the retaining site. and a (, second shape with an expanded outer diameter is formed when the retaining device is released from radial constraint at the retaining site. Either a coaxial delivery sheath or a coaxial delivery wire may provide this radial constraint.
Alternatively, the retaining device may be balloon expandable from the first shape S to the second shape.
In another retaining device variation, at least one semi-penetrable space is provided in the barrier formed at the entrance zone into the body space to be occluded. This retaining device may be delivered to the retaining site, followed by introduction of at least one occlusion device into the body space to be occluded through the semi-penetrable space.
In another aspect of the invention, the retaining device may be a metal wire wound into a primary helix that has a secondary geometry which is also a secondary helix. The adjacent windings of the secondary helix may be the semi-penetrable space provided by the appropriate retaining device variation.
1 S In another variation, the semi-penetrable space is sized to allow at least one occlusion device, when radially artificially constrained to a first occlusion device outer diameter, to be inserted therethrough. Subsequent release of the radial constraint on the occlusion device allows it to reconfigure to a second outer diameter which prevents migration back through the semi-penetrable space.
In still a further variation, the semi-penetrable space of the retaining device is distendable. A delivery catheter with a tapered tip may be provided such that the semi-penetrable space is distendable by forcing the delivery catheter tip therethrough and into the body space to be occluded. Alternatively to a tapered-tip delivery catheter, an introduces wire is provided to distend the semi-penetrable spaces of the retaining device. At least one occlusion device is introduced into the body space to be occluded either coaxially through the delivery catheter or over the introduces wire. Subsequent withdrawal of the delivery catheter or introduces wire allows the once distended semi-penetrable space to reform to its original shape. forming a barrier-against migration of the occlusion devices out of the ~0 occlusion site and into the adjacent lumen.

In a further variation of the artificial occlusion kit, the retaining device is a wire wound into a primary helix over a core member. In a preferred variation of this embodiment, the core member is a metal, preferably a shape-memory alloy, and most preferably a shape-memory alloy of nickel and titanium. The wire is also preferably a metal, most preferably radiopaque.
Each of the variations discussed herein may further include a smaller diameter "leading helix" in the retaining device to assist in the alignment and deployment of the retaining device as it exits the catheter.
An implantable medical device assembly is also provided, having the structure described for the retaining device of the novel artificial occlusion kit and which is attached to an elongate pusher via a sacrificial link that is electrolytically dissolvable. In one variation, this implantable medical device may take the form of the "wire wound over core member" variation described for the artificial vaso-occlusion kit aspect of the invention.
1 S This invention includes methods for using the apparatus here described.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 A shows a side view of a vessel with an aneurysm in its wall, wherein a vaso-occlusion coil component of an artificial occlusion kit is shown '_'0 being delivered into the aneurysm.
Figure I B shows a side view of the vessel and aneurysm of Figure 1 A, wherein a retaining device assembly of the artificial occlusion kit is shown being delivered to a retaining site in the vessel adjacent the aneurysm which is substantially filled with a plurality of vaso-occlusion coils.
2~ Figure IC shows a side view of the same vessel and aneurysm wherein the retaining device is shown electrolytically detached from a pusher, the retaining device engaging the vessel wall adjacent the entrance zone of the aneurysm.
bridging across the entrance zone to form a barrier against vaso-occlusion coil migration into the vessel, and forming a lumen allowing for physiological flow through the vessel.
Figures 2A-2C show in partial section, a side view of an electrolytically deployed device.
Figure 3 shows in side view cross-section, a portion of the device shown in figures 2A-2C emphasizing the section of the device employing an electrolytically erodible link.
Figures 4A, 4B, and 4C show in partial cut-away, cross-section, variations of the shape of retainers made according to this invention.
Figure 5 shows a side view of a vessel having in its wall a wide-neck aneurysm, showing a variation ~f the artificial occlusion kit where the retaining device has a semi-penetrable space through whic!~ an artificial occlusion device is being introduced into an aneurysm.
Figure 6 shows a side view of a vessel having in its wall a wide-neck aneurysm, showing a variation of the artificial occlusion kit where the retaining device has a distensible semi-penetrable space that is shown distended by a delivery catheter through which vaso-occlusion coils are being introduced into the aneun~sm.
Figure 7 shows a side view of the vessel and wide-neck aneurysm, showing a further variation of the assembly shown in Figure 5, wherein the distensible semi-penetrable space is shown distended by an introducer wire over which vaso-occlusion coils are being coaxially advanced into the aneun-sm.
Figure 8 shows a perspective view of a further variation of retaining device wherein the retaining device is shown to be constructed of a wire wound into a 2~ helix over a core member, the helical wire and core member being formed into a secondary geometry.
Figures 9A and 9B show in schematic cross-section anatomically shaped filler coils suitable for use in conjunction with the retention devices made according to this invention.

The present invention provides a novel solution to the problem of vaso-occlusion device migration out of aneurysms or other implantation sites and into the feeding vessels that are not the target of vaso-occlusion. A retaining device is used in a novel artificial occlusion assembly to prevent migration of one or more occlusion devices from a target occlusion site by forming a barrier at the entrance zone to the target site from a feeding vessel. Variations of a novel implantable medical device are provided as the retaining device, which novel implantable medical device is included within the scope of the present invention.
Artificial Occlusion Kit wJ Retaining Device Figures 1 A-C show sequential steps of a novel method of occluding a body space -- here an aneurysm of a body lumen wall -- using one artificial occlusion kit embodiment of the current invention. In this series of Figures, a retaining device is provided in a kit together with at least one vaso-occlusion device, which kit is also shown in use with at least one delivery catheter.
Figure lA shows the first of a plurality of vaso-occlusion coils is shown as it is being implanted into an aneurysm. In Figure I B, a retaining device of a retaining device assembly is shown being delivered to a retaining site in the body lumen adjacent the aneurysm after the aneurysm is substantially occluded with vaso-occlusion coils. In Figure 1 C, the retaining device is completely implanted at the retaining site and detached from a pusher via electrolytic detachment from a pusher. The implanted retaining device shown forms a barrier against migration of the vaso-occlusion coils from the aneurysm and into the body lumen, while maintaining an open conduit for flow through the body lumen.
In Figure 1 A, a cut-away side view of a vessel (2) having an aneun~sm (4) in its wall is shown. Vaso-occlusion coil (8) is shown being delivered into aneurysm (4) out of the distal end of delivery catheter (10) in order to occlude the ~0 aneuy sm (4).

Vaso-occlusion coil (8) for the purposes of this invention may be any one of a wide variety of coils that are known in the art for occluding vessels or aneurysms. For example, vaso-occlusion coil (8) may be a pushable coil of the type described in US 4,994,069. Or, coil (8) may be a mechanically detachable S coil such as that described in US 5,261,916 or US 5,250,071. Alternatively, coil (8) may be an electrolytically detachable coil such as that described in US
5,122, I 36 or US 5,354,294.
Still further, vaso-occlusion coil (8) may have a pre-formed secondary shape that is constrained in a stretched orientation when being delivered through delivery catheter (10) but reconfigures when delivered beyond delivery catheter ( I 0). Such reconfiguring often includes radial expansion to a relaxed memory state having a desired, pre-determined shaped geometry. Alternatively, coil (8) may have highly flexible portions that ball up from random convolutions formed while the coil flows distally during delivery, such as the coils described in I S pending US Pat. Appl. No. 08/413,970, filed March 30, 1995.
The type and geometry of vaso-occlusion coil are normally chosen for the particular delivery mechanism and space-filling characteristics, as may be appropriate for a particular occlusion site. ' The appropriate design for delivery catheter (10) is defined by the ability to reach the desired occlusion site atraumatically and to efficaciously deliver the vaso-occlusion coil into the site as an occlusion implant. One example of a catheter that may be used in the present invention is described in US
4,739,768 to Engelson.
Figure 1B shows a retaining device (19) being delivered through delivery catheter (20) and into vessel (2) at the site of aneurysm (4). A plurality of vaso-occlusion coils (12) is also shown having been implanted into aneurysm (4) prior to delivery of the retaining device ( I 9). Retaining device ( 19) is shown as a distal segment of a retaining device assembly ( 15), wherein it is attached at its proximal end to a pusher ( I 6) which is relatively more stiff than the implantable retaining device ( 19). Pusher ( 16) is adapted for advancing the retaining device percutaneously through the delivery catheter (20), even when in tortuous bends of the vasculature, into remote internal body spaces for occlusion.
In retaining device assembly (IS), retaining device (19) and pusher (16) are shown to be coupled or attached via a joint or link (17). The scope of this invention contemplates that retaining device (19) and pusher (16) can be either electrolyically detachable at link (17) or mechanically detachable at link (17). In the electrol5~tically detachable embodiment, link ( 17) is electrolytically dissolvable when current is applied thereto. Electrolytic detachment mechanisms of the types described in US 5,122,136 or US 5,354,295 may be suitable. In the mechanically detachable embodiment, pusher (16) and retaining device (19) are mechanically detachably engaged at link (17). In such an assembly, the mechanical detachment mechanisms of the types described in US 5,261,916 or US
5,250,071 may be suitable.
It is further contemplated that the use of a retaining device to prevent migration of vaso-occlusion devices from an occlusion site need not be limited to use with a "detachable" pusher-retaining device mechanism as is shown in retaining device assembly ( 15). It may be equally efficacious, and perhaps even preferred in a given circumstance, to use separate, non-attached retaining device and pusher without the need for a detachable link such as Iink (17).
Where the pusher is separate and not attached to the retaining device, pushers such as the type described in US 4,994,069 to Ritchart et al. may be satisfactory. In use, the distal end of the pusher can be advanced axially within a delivery catheter lumen to abut a proximal end of the retaining device, also disposed within the delivery lumen. With the distal pusher end in confronting engagement with the retaining device proximal end, further advancement of the pusher by the user will effectively push the retaining device distally through the lumen, out of the delivery catheter from a distal port thereof, and into a vessel site adjacent a body space where occlusion devices are deployed.
In the artificial occlusion kit variation of Figure 1 B, retaining device ( 19) has a memory in the form of a pre-determined, shaped, secondary geometry.
Retaining device (19) is shown to have a first shape with a first outer diameter "A" where it is positioned within delivery catheter (20). The delivery lumen (22), which ends distally in distal delivery port (23), radially constrains the retaining device such that the first outer diameter is defined by the delivery lumen (22) inner diameter. When released from a radially constraining condition, retaining device ( 19) also forms a second shape with a second outer diameter greater than the first outer diameter "A." and sufficient to engage the vessel wall. In Figure 1B, retaining device (19) is shown extending beyond the distal delivery port of the delivery lumen (22) where it is radially artificially unconstrained and expanded to an outer diameter "B" larger than the first diameter "A," engaging the lumen wall at the retaining site adjacent the aneurysm.
It is contemplated that the completely relaxed, unconstrained second outer diameter of the retaining device may be slightly greater than the diameter of the vessel. This may be necessary in order to maintain accurate placement of the retaining device in the vessel lumen at the aneurysm site. However, the purpose of the retaining device is merely to form a barrier at the entrance zone of the aneurysm to prevent occlusion coil migration. Unnecessary trauma to the vessel wall, such as from oversizing or coil designs that are too stiff to perform the stated purpose should be avoided.
Retaining device (19) is shown in Figure 1B to have a helical geometn~.
2~ In one preferred embodiment, retaining device (19) is a metal wire that is wound into a primary helix, shown in Figure 1 B having a primary helix diameter "C".
This primary helix is preferably pre-formed into a secondary geometry that. as shown for this embodiment, is also in the form of a secondary helix.
Therefore.
the first and second shapes and corresponding first and second outer diameters that the retaining device takes when being delivered to and implanted in the 1;

vessel, respectively, are defined by the secondary geometry of the retaining device. These shapes are formed about a longitudinal axis, shown in Figure I B
at "L," and their respective outer diameters are defined on a radial plane perpendicular to that axis.
Retaining device (19) is also shown in Figure 1B to form a lumen (30). In this embodiment, lumen (30) is defined by the simple helical shape of the retaining device's secondary geometry and extends along the longitudinal axis "L"
of that helix. It is contemplated that first and second shapes other than a simple helix may still fall within the scope of the present invention. However, the purpose of the retaining device is to form a barrier at the entrance zone to the body space being artificially occluded by occlusion devices. Occlusion of the body lumen adjacent to the occlusion site is to be avoided in the use of the present invention. It is therefore an important aspect of the present invention that there be a physiologically acceptable through-lumen formed by the retaining device when I S implanted into the body lumen.
In the artificial occlusion kit embodiment of Figure 1B, delivery catheter ( 10) may be the same catheter as that used for delivering the occlusion devices, such as deliver, catheter ( 10) in Figure 1 A. Or, the two delivery catheters may in certain circumstances have different required characteristics for delivering the occlusion devices and retaining devices, respectively. For instance, a desired tip shape for delivering the occlusion devices into an aneurysm radially at the vessel wall may be different than the tip shape appropriate for delivering the retaining device transversely into the vessel lumen adjacent the aneurysm. Similarly, the retaining device and the occluding devices are characteristically of different designs, since one's function is to substantially space fill and the other's is to fonm a barrier at the aneurysm and aiso to keep the vessel lumen open. Thus, the delivery catheters for the two designs may require different delivery lumen diameters. material construction. etc. as may be appropriate according to one of ordinaw skill.
1-~

The current invention further contemplates radially expandable retaining device assemblies other than the type that is delivered through a radially confining sheath. For instance, a delivery wire may provide a coaxial rail over which a retaining device may be advanced such as by a pusher located proximally of the retaining device. In such an assembly, the retaining device may have a lumen that coaxially tracks the delivery wire, the delivery wire providing radial constraint on the retaining device to form the first radially constrained shape. Advancing the retaining device distally past the end of the delivery wire releases the radial constraint and allows the retaining device to expand to a second shape.
Alternatively, a further retaining device variation may be delivered upon and expanded by a balloon on the distal end of a balloon catheter. In such a variation, the retaining device is provided for delivery to the retaining site while it is formed in its first shape coaxially engaged over a balloon in a deflated state.
Once at the retaining site, inflation of the balloon radially expands the retaining device into a second shape having an outer diameter sufficient to engage the vessel wall and which forms a barrier across the entrance zone to an aneurysm.
Subsequent deflation and withdrawal of the balloon leaves the radially expanded retaining device implanted at the retaining site, which retaining device forms a lumen where the expanded balloon once was.
F~ectrol ~t~ ieallv Detachable Retaining Device In Figure 1 C, a particular retaining device variation is shown detached at the retaining site in vessel (2) that is adjacent to a body space to be occluded, here aneurysm (4). Retaining device ( 19) is shown having a shape that is expanded along its length to a diameter sufficient to engage the vessel wall at regions adjacent an entrance zone (6) to aneurysm (4). Retaining device (19) also bridges across entrance zone (6) and forms a barrier against any of the pluraliy of vaso-occlusion devices ( 12) from migrating out of the aneurysm and into vessel (?).
In the embodiment shown in Figure 1 C. retaining device ( 19) has been detached from pusher ( 16) by means of electrolyic or erosive severing of link 1~

(17). As mentioned earlier, such electrolytic detachment may occur via the systems and methods as described in US 5,122,136; US 5,354,294; or co-pending Canadian Application No. 2,180,750, as may be apparent to one of ordinary skill in the art.
Much different from those disclosures, however, is the fact that the retaining device of the current invention is not ;an occlusion device and must provide a through-lumen for flow when implanted) into a vessel lumen (in fact the opposite function of the previously disclosed ele~ctroIytically detachable occlusion devices).
Briefly, however, power source "E" is electrically caupled to electrolytically severable link ( 17). An electrode (40) is also shown schematicall}~
in Figure 1 C, where it is also shown electrically coupled with power source "E.'' Electrode (40) may be a skin electrode having a relatively high surface area in contact with the patient when compared to that of link ( 17).
In clinical use, retaining device assembly (15) is disposed within the body such that lint: (17) is in patient contact. Since electrode (40) is in skin contact with the patient, a circuit may be formed wherein direct current from power source "E" may pass through link (17), quickly dissipate at a low current density through the patient as an electrical conductor, and through electrode (40) back to power source "E." This current serves to dissolve lint: (17) until retaining device ( 19) is detached from pusher ( 16).
Power source "E" may additionally superimpose an alternating current over the direct current signal, which alternating current signal may be sensed by a sensing circuit (not shown) as an indicator of the progression of electrolytic detachment at link (17). Additionally, a control circuit (not shown) may be used to alter the output power signal or shut the signal off upon the sensing of a critical parameter by the sensing circuit, such as the sensing of a particular change in the alternating current component of the output signal. Such monitoring and feedback control of electrolytic detachment may employ the apparatus and methods as described in co-pending Canadian Application No. 2,162,1 lL7 (previously discussed).
In the artificial occlusion kit embodiments described, cross sectional intrusion into the vessel lumen where implanted should be kept to a minimum.
Beneficially to this invention, the electrolytic detachment allows for minimal engaging structure at the detachable coupling end of the implantable medical device (as compared to mechanically detachable designs which may require clasps, enlarged balls, etc. on the end of the implant coil). It is believed.
therefore, that electrolytic dissolution of link (17) thus provides an optimal solution for implanting an implantable medical device for use as an occlusion coil retaining device.
Figures 2A-2C depict a different variation of the artificial occlusion kit. In this variation, a vaso-occlusive coil (I2) is maintained in an aneurysm (4) emanating from an artery (2) by a retaining device assembly (30) which is delivered to the site of the aneurysm (4) by guidewire. The retaining device assembly (30) is maintained in a radially compressed fashion by the use of a pair of electrolytic lima (32, 33). As will be shown below in discussion of Figure
3.
Figure 2A shows the retaining device assembly (30) closely coiled to the body of the core or guidewire (31). Preferably, the retaining device assembly (30) is of a material or has been treated in such a way that the "normal" or relaxed condition of the retaining device assembly (30) is as shown in Figure 2C. A
single wire device is depicted in Figures 2A, 2B and 2C, but a helically wound coil is certainly suitable as well. In the variation shown in these figures, the retaining device assembly (30) must be either insulated in its entirety from the surrounding fluid (via, e.g., a plastic coating or the like) or of a material which is more noble or higher in the electromotive series than are the links (32) and (33) shown in the drawing. Further, the guidewire (31 ) distal tip coil (34) and the like must be insulated as well. As was discussed above in some detail, this detachment link operates via the electrolytic erosion of the bard links found at (32) and (33). In the sequence shown in Figures 2A. 2B and 2C, the link found at (3) is smaller in diameter than is the link found at (32). In this way, as current is applied to core wire (3 I ) and passes from that core wire into the links (32) and (33), link (33) erodes to a point where it breaks earlier than does the lint;
at (32) simply because of the smaller diameter of link (33).
Once lint: (33) has disintegrated as is shown in Figure 2B, link (32) continues to electrolvtically erode as time passes. After the second joint (32) has broken and the retaining device assembly (30) has expanded as shown in Figure 2C, the core wire and its allied parts (31 ) are removed.
Figure 3 shows a portion of the core wire (31 ) with the retaining device assembly (30) closely disposed on its outer surface as would be the case in Figure 2A. In this close up arrangement, the inner core (36) is covered by an insulating layer (37) of; e.g., a polytetrafluoroethylene. The displayed link (33) is in an electrical contact with the core (36) and holds the retaining device assembly (30) in close contact with the core wire assembly (31 ). It is this lint; (33) which erodes to release the retaining device assembly (30).
Figure 4A shows a variation of the overall shape of a retaining device assembly (38) made in keeping with this invention. In particular, the retaining device assembly (38) has two end regions (39) which have a diameter when deployed which approximates (or is slightly larger than) the inner diameter of the vessel lumen into which it is placed. The retaining device assembly (38) has a center section (41 ) which has a smaller overall radius than the two end sections (39). The smaller mid-section (41 ) has a variety of benefits. For instance, it does not press on the vessel or on the coil (12) within aneurysm (4). Yet it is sufficiently close to the mouth of aneurysm (4) to prevent coil ( 12) from migrating to other parts of the body. The retaining device assembly (38) made in this form is easier to move should it be mal-placed in the human body. It has smaller regions in contact with the vessel lumen.
The shape of the device is not particularly critical in many of these variations. The shape of retaining device assembly (38) must be sufficiently appropriate for it to maintain the coil (12) within aneurysm (14). It must have sufficient radial springiness to allow its shape to be maintained in the lumen of the body vessel described herein.
We have found that, on occasion, the retaining devices shown in the Figures will not achieve the desirable generally cylindrical shape found in those Figures. This problem can be alleviated in a variety of ways. A careful user will find it possible to twist the catheter during the initial ejection of a couple of turns of the retaining device assembly to maintain the device in the proper orientation in the lumen. Some users will find that the use of a catheter distal tip havinb a turn will help in deployment f the retainer. One very effective and highly desirable method of preventing the retainer from turning in the vessel lumen during deployment is found in Figures 4B and 4C. In this variation of the invention, the retaining device assembly (43 in Figure 4B and 46 in Figure 4C), incorporates a leading or distal helix section which has a deployed diameter which is smaller than the diameter of the vessel lumen.
IS In Figure 4B, the retaining device assembly (43) is first deployed to the right (or distal end) of the Figure. The proximal end of the retaining device assembly has a diameter (44) which is equal to or larger than the diameter of the vessel lumen. the earlier deployed distal end has a smaller diameter (45).
during deployment of the device, the smaller diameter distal section exits the catheter end and simply forms a tubular cylinder within the lumen of the vessel. The distal end of the retainer device assembly (43) conceptually forms an indexing end and aligns the remainder of the retainer device assembly (43) with the lumen for further deployment. The distal diameter (45) should not be appreciably smaller than the lumen diameter (44) lest the retaining device assembly (43) begin to 2~ block blood flow. We believe that the distal diameter (45) should be at least 75%
of the lumen diameter (44).
It should also be noted that the proximal diameter portion of the retaining device assembly (43) does not completely cover the mouth (6) of the aneun~sm
(4) in the Figures. This is not critical but the is an option in this variation.

Figure 4C shows a similar variation of the invention in which the distal portion of the retaining device assembly (46) is stepped and has two short sections of respectively smaller diameters (48,49).
Semi-Penetrable Retaining Device A further artificial occlusion kit embodiment allows for implantation of the retaining device prior to implantation of occlusion devices, an embodiment particularly useful in ''wide-neck" aneurysms. In artificially occluding these types of body spaces using conventional systems, occlusion devices may not be implantable at all into the aneurysm without immediate migration into a flowing vessel prior to insertion of a retaining device at the entrance zone. This embodiment solves this problem by providing semi-penetrable spaces in the retaining device at the entrance zone from the body lumen to the adjacent body space to be occluded.
As is shown in Figures 5-7, the retaining device in the variations of this embodiment may be a helically wound member, wherein the semi-penetrable space for occlusion device insertion is provided by the space between adjacent windings of the helix. In a preferred mode, the helically wound member that forms the retaining device is a metal wire wound into a primary helix which is further wound into a secondary helix. In this mode, windings of the secondal-y helix form the semi-penetrabl; space for occlusion device insertion.
In the variation shown in Figure 5, the pre-determined, semi-penetrable space (60) of retaining device (69) is defined by the space between adjacent helical windings (58) and (59). This semi-penetrable space (60) is equal to or greater in diameter than occlusion device (62) when it is being introduced into aneurysm (54). However, semi-penetrable space (60) is less than the diameter of occlusion device (62) after it is in the aneurysm. Thus, in this embodiment, the spacing provided by the retaining device allows the introduction of occlusion devices into the aneurysm but does not allow significant migration of occlusion devices. once implanted, back into the adjacent vessel lumen (~3).

More particularly, in Figure 5 the occlusion device (62) is radially constrained to a first shape having a first outer diameter when within the delivery lumen of delivery catheter (70). The delivery catheter distal end is abutting the inner surface of the retaining device (69). The occlusion device (62) is then S advanced out the distal end of the delivery catheter (70) and through the space in the retaining device (69), where it is then radially artificially unconstrained. Once released into the aneurysm sac through the retaining device semi-penetrable space, the occlusion device (62) takes on a second shape having a second outer diameter that prevents it from migrating back through the semi-penetrable space and into the body lumen (53).
In a more particular embodiment of the artificial occlusion kit shov~m in Figure S, the semi-penetrable spaces of the retaining device are distensible.
This distensibility enhances the semi-penetrability of the spaces. More specifically, occlusion devices may be introduced through such spaces when an applied force distends open the spaces. Once the occlusion devices are implanted into the occlusion site, however, passive migration of the devices back through the spaces does not provide the requisite force to distend open these spaces--the passive migration is thus prevented.
In one aspect of this variation, a particular occlusion device may be used in conjunction with a retaining device, and be of such construction and dimension that it may be advanced unaided through the spaces provided in the retaining device. For example, detachable occlusion devices such as those described in US
5.122,136 or US 5,354,295 may be constructed with sufficient pushability to be advanced between adjacent coil winds of the retaining device and into the aneurysm sac. They may thereafter be detached within the aneurysm for occlusion.
Another aspect of this variation is shown in Figure 6. Here. retaining device (119) is shown implanted into vessel (102) such that it radially engages the vessel wall adjacent to entrance zone (106) to wide-neck aneun~sm (104) and brides across entrance zone (106). The helical shape of retaining device (119) is show to have a pre-determined spacing which may be spread when adjacent helical windings are forced apart. In Figure 6, delivery catheter (110) is advanced through the retaining device and into the entrance zone ( 106) of the aneurysm ( 104).
In the particular variation of Figure 6, delivery catheter (110) has a tip ( 1 I 1 ) which is tapered and dimensioned such that adjacent helical windings of retaining device (119) are forced apart when delivery catheter (110) is forced radiallv against the retaining device ( 119) from its inner lumen ( 130) and toward the entrance zone ( 106). To achieve this interaction, delivery catheter ( 1 I
0) ma~~, for example, have a pre-shaped bend in the distal delivery catheter region ending in tip ( 111 ). This shape may aid in the advancement of the delivery catheter through the branching vasculature, or may also be sufficiently straightened coaxially over a guidewire to avoid proximal vessel trauma while tracking to the site.
1 S In a further variation shov~m in Figure 7, an introduces wire (140) may be forced through spaces provided in the retaining device, such as between adjacent winds of a helically shaped retaining device as shown in Figure 7. Once the introduces wire (140) is advanced through the retaining device and into the aneurysm, a delivery catheter such as delivery catheter (110) (shown in Figure
6) may thereafter be advanced coaxially over the introduces wire ( 140) and into the entrance zone of the wide-neck aneurysm. An advantage to using an introduces wire in this technique as compared to that previously described in reference to Figure 6 is that the delivery catheter may be introduced into the aneurysm over the introduces without the need for preshaping the delivery catheter.
2~ In the particular variation of Figure 7, however, delivery catheter (120) is not shown to be advanced into entrance zone ( 106) or aneurysm ( 104), but rather is advanced merely to abut the inner diameter of the helical windings forming retaining device (I 19). Vaso-occlusion coil (108) is shown being advanced coaxially over introduces wire (140) while advancing through delivery catheter (120). through adjacent windings of helical retaining device (119). and ultimately off the distal end of introducer wire (140) and into the sac of aneurysm (104).
Such coaxial advancement of vaso-occlusion coil ( 108) may occur, for example, by coaxially advancing a pusher member, located proximally of vaso-occlusion coil (108), in the distal direction against a proximal end of vaso-occlusion coil.
S The critical performance of the introducer wire is that it must be sufficiently stiff and of such diameter and geometry to allow it to pass through the spacing provided in the retaining device ( 119). However, it should also not be too stiff so as to present risk of trauma or perforation of the thinned aneurysm wall.
Such introducer wire (140) may also be shapeable such that it is adapted for tracking to the retaining site adjacent the aneurysm, as well as for advancing through the spaces in the retaining device barrier at the aneurysm entrance zone.
Conventional guidewires of the type known in the art may perform sufficiently as introducer wire ( 140) in a particular case. Alternatively, the present invention further contemplates obvious alterations to known wire designs in order to function with the individual features of a particular retaining device design, as may be apparent to one of ordinary skill. Such particularized retaining device features that may dictate introducer wire design parameters, for example, may be the diameter and degree of distensibility of the semi-permeable space.
"Coil Over Core" Retaining Device A further embodiment of the present invention is shown in Figure 8. In this variation, the implantable medical device that functions as a retaining device in the novel artificial occlusion kit has a particular construction that includes a wire (202) wound into a primary helix over an inner core member (204). The inner core member (204) and primary wire helix are also wound into a secondary geometry, and are soldered or welded at both of two ends (210) and (212). The secured ends (210) and (212) serve to secure the "wire over core" composite relationship and also provide smooth ends for safety considerations in this implantable device.

Preferably, the inner core member (204) is a metal mandrel, and more preferably is a superelastic alloy of nickel-titanium. In one particular variation, the inner core member (204) is constructed of a nickel-titanium alloy and has an outer diameter from 0.003" to 0.006". The heIically wound wire (202) in this preferred variation may be a radiopaque metal, such as platinum, gold, or tungsten, and has an outer diameter in the range of 0.001 " to 0.006". The coil may have 0-100% spacing. Preferably, wire (202) is wound at a pitch of 0.001"
to 0.008" with 0-100% spacing. For instance, a coil made with 0.003" wire with 0.006'' pitch has 100% spacing; a coil with 0.003'' wire and 0.006" pitch has spacing.
In this variation, wire (202) is secured to the inner core member (204) using the following process: the coil is secured to the inner core member at least two or several locations, preferably at both ends. One method for joining the components involves resistance welding or a similar such process. Soldering or brazing is similarly useful in joining the metals.
In the "wire over core" combination structure such as that just described, the inner core member (204) is chosen such as to provide the requisite shape memory and stiffness. This inner core member may not by itself provide optimal radiopacity, since it is not chosen for that purpose. The requisite radiopacity of the device may instead be provided by the outer wound coil (202), which might not provide optimal stiffness or material memory if it were only available alone in the device. It is believed that the combined features of this "wire over core"
design may optimally adapt prior known implantable coil technologies to meet the particular structural needs of a retaining device in the current invention.
2~ For instance, it is important that the elongate retaining device be flexible along its length so that it can be implanted into lumens having bends.
However, it is believed that too much flexibility may correspond to irregular and random conformations of the coil when implanted in-vivo, which may produce an occlusive effect. A primary helical coil wound into a secondary helix, without ~0 more. may be too flexible to effectively engage a vessel wall along the requisite ~4 length to form a barrier against occlusion device migration. However. the addition of the mandrel in what would otherwise be the primary helix lumen provides a stiffening structure that still allows for a certain controlled flexibility of the secondary helical shape.
Additionally, prior vaso-occlusion coils require substantial space filling for effective cross-sectional blockage of a body lumen, for example. In these devices, only a minimal portion of the device may be required to actually radially engage a vessel wall for primarily the purpose of anchoring the device at the occlusion site.
This means only a small portion of the coil may need to reconfigure from a first constrained diameter during delivery to a second diameter at least approximating the lumenal wall diameter when delivered. It may be acceptable, even desirable, for such occlusion coils to have portions not so significantly altered in their cross-sectional diameter when they are delivered at an implantation site, so long as their shape presents an occlusion to flow.
1 S In contrast, the present inventive retaining device must take on a shape at the retaining site that has sufficient outer diameter along a sufficient length of the device to form an effective barrier across the aneurysm entrance zone at the vessel wall. Impinging into the lumen's cross-section is generally undesirable. The reconfiguration to this expanded shape from a first radially constrained shape during delivery may correspond to a higher degree of requisite material memory than is possible from a simple fine wire wound into the primary and secondary helix shapes as previously disclosed. An inner core mandrel, however, may offer the structure necessan~ to provide such memory.
In another particular retaining device variation, the wire forming the ?~ primary helical core is wound much tighter than a similar wire might be wound to optimally form an occlusion device. It is believed that coil stiffness may be controlled by adjusting the outer diameter of the primary coil helix (e.g.
tightness of winding) to which a given wire is wound. It is believed that, by providing one preferred retaining device may comprise a wire wound very tightly into a primary helix that has also a secondary shape.

One preferred application of this "tightly wound" variation comprises a platinum wire of 0.005" outer diameter wound over a .009" mandrel. In contrast, common known occlusion coils for occluding aneurysms is constructed a .005"
wire wound over a .011" mandrel. Similarly, when a smaller diameter primary S helix i s desired, a wire having an outer diameter of .003" may be wound over a mandrel having an outer diameter of 0.007". In any case, the wire is thereafter annealed in the wound shape to form a primary coil of pre-determined dimensions. A secondan~ shape may then be imparted to the primary coil, which secondary shape ma5- also be a helical coil.
It should be apparent to those skilled in this art that the coil placed within an aneurysm need not be the random shape described and shown above. indeed, many shapes would be suitable for use with this invention. We have found that anatomically shaped oval (222) or semi-oval (224) coils are suitable for this invention. It should be apparent that both these are regularly wound and are provided with the shape of the anatomical cavity into which they are placed.
Coils (222) and (224) provide a similar amount a rate of occlusion within the aneurysm structure and yet do so with a significantly smaller mass of coil than the random shapes :-.hown above in many of the drawings.
Other Clinical Applications and Design Embodiments The ultimate goal of the particular artificial occlusion kits, novel components thereof, and related methods described above is to occlude aneurysms having entrance zones or necks that are of such width and geometry that conventional techniques would result in unwanted migration of occlusion devices from the aneurysm and into the adjacent vessel. However, the assemblies, components, and methods of the present invention that were conceived of in order to meet this need may provide additional benefits in other medical treatments.
Additionally. the invention contemplates retaining device designs that meet the general requirements of the novel artificial occlusion kit but vary from the specific variations just described.

In one aspect of the invention, for example, the artificial occlusion kit embodiments and variations have been described specifically as applied to aneurysms in vessel walls. However, other occlusion sites adjacent to and in fluid communication with body lumens may present similar concerns as to migration of occlusion devices from an occlusion site and into an adjacent lumen. For instance, a vessel that branches off of a feeding vessel may be a body space to be occluded and the feeding vessel at a region adjacent to the branching vessel may be a desired retaining site. The present invention contemplates use of the apparatus embodiments described in such body spaces and lumens in addition to aneurysm sites in vessels.
The invention also broadly contemplates a retaining device structure that is expandable at a retaining site of a body lumen to form a barrier against migration of at least one occlusion device through an entrance zone between an occlusion site and an adjacent lumen, and that also provides a lumen for flow through the body lumen at the retaining site. Examples have been provided in the form of shape memory coils delivered through radially confining delivery sheaths or over delivery wires, in addition to an alternative balloon expandable retaining device embodiment. Various specific retaining device designs that meet the broad requirements provided, beyond the particular variations provided, are within the scope of this invention.
Also, while various retaining device designs may meet the requirements of the novel artificial occlusion kit described, at least one novel electrolytically detachable implantable medical device has been conceived of for use as a retaining device in the artificial occlusion kit. This novel implantable medical device may have useful medical applications in addition to retaining artificial occlusion devices. The scope of this aspect of the invention, while intimately pertaining to an artificial occlusion kit, should not be limited to the kit embodiments described for artificial occlusion.
?7 Modification of the above-described variations for carrying out the invention that would be apparent to those of skill in the fields of medical device design are intended to be within the scope of the following claims.

Claims (33)

WE CLAIM AS OUR INVENTION:
1. An artificial occlusion kit for implanting and retaining an artificial occlusion device in a body space to be occluded adjacent to and extending from abody lumen in a mammal, comprising:
at least one occlusion device adapted for filling at least a portion of the body space; and a retaining device assembly having a retaining device adapted to be delivered and implanted at a retaining site in the body lumen adjacent to the body space, said retaining device having two opposite ends and forming a first shape with a first outer diameter, said retaining device being expandable to a second shape having a second outer diameter larger than said first outer diameter and sufficient to engage a body lumen wall at the retaining site such that a barrier is formed against migration of said at least one occlusion device out of the body space and into the body lumen, said second shape also forming a lumen along a longitudinal axis sufficient to allow flow of fluids therethrough.
2. The artificial occlusion kit of claim 1, wherein said retaining device forms said first shape when radially constrained for percutaneous delivery to the retaining site, and forms said second shape upon release from said radial constraint at the retaining site.
3. The artificial occlusion kit of claim 2, further comprising a delivery catheter having a proximal delivery catheter end with a proximal delivery port, an opposite distal delivery catheter end portion with a distal delivery port, and a delivery lumen extending between said delivery portsand having a delivery lumen inner diameter less than said second outer diameter,wherein said retaining device is slideably disposable under radial constraint within said delivery lumen.
4. The artificial occlusion kit of claim 3, wherein said retaining device assembly further comprises a pusher that is coaxially slidable within said delivery lumen and has a distal pusher end portion and a proximal pusher end portion, wherein said distal pusher end portion may be advanced through said delivery lumen in confronting engagement with a proximal end of said retaining device such that said retaining device may be pushed with the pusher out of the delivery lumen through the distal delivery port and into the body space.
5. The artificial occlusion kit of claim 2, wherein said retaining device assembly further comprises a pusher having a distal pusher end portion that is detachably secured to said retaining device and a proximal pusher end portion that is adapted to be axially manipulated by a user.
6. The artificial occlusion kit of claim 5, wherein said distal pusher end portion is electrolytically detachable from said retaining device via an electrolytically severable link.
7. The artificial occlusion kit of claim 6, further comprising:
a power source electrically coupled to said electrolytically severable link;
and an electrode electrically coupled to said power source;
wherein a circuit is formed when said electrode and electrolytically severable joint are both in contact with a patient.
8. The artificial occlusion kit of claim 5, wherein said distal pusher end portion is mechanically detachable from said retaining device.
9. The artificial occlusion kit of claim 3, wherein said retaining device comprises at least one wire wound into a primary helix and having a secondary shape imparted thereto.
10. The artificial occlusion kit of claim 9, wherein said primary helix forms a primary helix lumen, said retaining device further comprising an elongate core member coaxially disposed within said primary helix lumen.
11. The artificial occlusion kit of claim 10, wherein said elongate core member is a metal.
12. The artificial occlusion kit of claim 1, wherein said second shape defines at least one semi-penetrable space between the body space to be occludedand the adjacent body lumen.
13. The artificial occlusion kit of claim 12, wherein said at least one occlusion device forms a first occlusion device shape that is advanceable through said semi-penetrable space, and is also expandable to a second occlusion device shape that is not advanceable through said semi-penetrable space.
14. The artificial occlusion kit of claim 12, wherein said second shape comprises a helix and said semi-penetrable space is the spacing between adjacenthelical windings of said helix.
15. The artificial occlusion kit of claim 12, wherein said semi-penetrable space is distensible.
16. The artificial occlusion kit of claim 15, further comprising:
a delivery catheter having a proximal delivery catheter end with a proximal delivery port, an opposite distal delivery catheter end portion with a distal delivery port, and a delivery lumen extending between said delivery ports, said distal delivery catheter end portion further having a tapered tip portion with a distal tip diameter smaller than said semi-penetrable space, wherein said semi-penetrable spacing is distensible by advancing said tapered tip portion at least partially therethrough, and wherein said at least one occlusion device is advanceable within said delivery lumen.
17. The artificial occlusion kit of claim 15, wherein said at least one occlusion device comprises two opposite ends and forms an occlusion device lumen extending between two opposite occlusion device ports at said opposite ends said kit further comprising:
an introducer wire being coaxially advanceable through said occlusion device lumen and through said opposite occlusion device ports, and having an introducer wire tip portion that is advanceable through and is adapted to distend said semi-penetrable spacing, wherein said at least one occlusion device is advanceable through said semi-penetrable spacing when said introducer wire tip portion is advanced through and distending said semi-penetrable spacing, and wherein said at least one occlusion device is prevented from migrating from a body space to be occluded and through said semi-penetrable spacing when said semi-penetrable spacing is not distended.
18. The artificial occlusion kit of claim 2, wherein said retaining device form said first shape when radially constrained for a percutaneous delivery to acore wire extending between said retaining device's opposite ends and constrained to said core wire by electrolytic links, and wherein said retaining device formssaid second shape upon electrolytic release from said radial constraint.
19. The artificial occlusion kit of claim 19 wherein said retaining device assembly and said core wire are insulated from any fluid found in said body space and body lumen.
20. The artificial occlusion kit of claim 1 wherein said at least one occlusion device approximates the shape of the body space into which it is placed.
21. The artificial occlusion kit of claim 1 wherein said retaining device assembly further comprises a distal end having a distal diameter smaller than said body lumen and said second outer diameter.
22. An implantable medical device assembly for engaging a body space wall in a mammalian body, comprising:
a.) an elongate implantable member having two opposite ends. and wherein said member forms a first shape having a longitudinal axis and a first outer diameter on a radial aspect of said longitudinal axis when radially artificially constrained for percutaneous delivery into a body space having a body space wall, and a second shape about said longitudinal axis upon release from said radial constraint, said second shape having a second outer diameter larger than said first outer diameter and sufficient to engage the body space wall and forming a lumen along said longitudinal axis with a lumen diameter sufficient to allow fluid flow through said implantable member; and b.) an elongate pusher extending from one of said opposite ends and being attached to said implantable member via an electrolytically severable joint.
23. The implantable medical device assembly of claim 22, further comprising a delivery catheter having a proximal end with a proximal delivery port, an opposite distal end with a distal delivery port, and a delivery lumen extending between said delivery ports and having a delivery lumen inner diameter less thansaid second outer diameter, wherein said elongate implantable member is slideably disposable under radial constraint within said delivery lumen.
24. The implantable medical device assembly of claim 22, wherein said implant able member comprises at least one wire wound into a primary helix and having a secondary geometry imparted thereto.
25. The implantable medical device assembly of claim 22, further comprising a power source electrically coupled to said electrolytically severable joint;
and an electrode electrically coupled to said power source;
wherein a circuit may be formed when said electrode and electrolytically severable joint are both in contact with a patient.
26. The implantable medical device assembly of claim 25, wherein said power source comprises a direct current source.
27. The implantable medical device assembly of claim 26, wherein said power source comprises an alternating current source.
28. The implantable medical device assembly of claim 27, wherein said power source produces a signal comprising an alternating current signal superimposed over a direct current signal, said assembly further comprising a sensing circuit for monitoring changes in said alternating current signal indicative of progression of electrolytic detachment of said implantable member from said pusher at said electrolytically severable joint.
29. The implantable medical device assembly of claim 24, wherein said primary helix forms a primary helix lumen, said implantable member further comprising an elongate core member coaxially disposed within said primary helix lumen.
30. The implantable medical device assembly of claim 29, wherein said elongate core member is a metal.
31. The implantable medical device assembly of claim 30, wherein said metal is a super-elastic alloy.
32. The implantable medical device assembly of claim 31, wherein said super-elastic alloy comprises nickel and titanium.
33. The implantable medical device assembly of claim 22 wherein said elongate implantable member having two opposite ends further comprises a distal end having a distal diameter smaller than said body lumen and said second outer diameter.
CA002211512A 1996-07-26 1997-07-25 Aneurysm closure device assembly Expired - Fee Related CA2211512C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/690,183 US5980514A (en) 1996-07-26 1996-07-26 Aneurysm closure device assembly
US08/690,183 1996-07-26

Publications (2)

Publication Number Publication Date
CA2211512A1 CA2211512A1 (en) 1998-01-26
CA2211512C true CA2211512C (en) 2000-11-28

Family

ID=24771444

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002211512A Expired - Fee Related CA2211512C (en) 1996-07-26 1997-07-25 Aneurysm closure device assembly

Country Status (11)

Country Link
US (3) US5980514A (en)
EP (1) EP0820726B1 (en)
JP (2) JP3205526B2 (en)
KR (1) KR980008179A (en)
AT (1) ATE249171T1 (en)
AU (1) AU709076B2 (en)
CA (1) CA2211512C (en)
DE (1) DE69724712T2 (en)
ES (1) ES2202553T3 (en)
NO (1) NO973373L (en)
TW (1) TW359601B (en)

Families Citing this family (353)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083220A (en) 1990-03-13 2000-07-04 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42625E1 (en) 1990-03-13 2011-08-16 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42756E1 (en) 1990-03-13 2011-09-27 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US6638291B1 (en) 1995-04-20 2003-10-28 Micrus Corporation Three dimensional, low friction vasoocclusive coil, and method of manufacture
US8790363B2 (en) 1995-04-20 2014-07-29 DePuy Synthes Products, LLC Three dimensional, low friction vasoocclusive coil, and method of manufacture
US6638293B1 (en) 1996-02-02 2003-10-28 Transvascular, Inc. Methods and apparatus for blocking flow through blood vessels
US6190402B1 (en) 1996-06-21 2001-02-20 Musc Foundation For Research Development Insitu formable and self-forming intravascular flow modifier (IFM) and IFM assembly for deployment of same
US6096034A (en) * 1996-07-26 2000-08-01 Target Therapeutics, Inc. Aneurysm closure device assembly
US5980514A (en) 1996-07-26 1999-11-09 Target Therapeutics, Inc. Aneurysm closure device assembly
US5733329A (en) * 1996-12-30 1998-03-31 Target Therapeutics, Inc. Vaso-occlusive coil with conical end
US5980554A (en) * 1997-05-05 1999-11-09 Micro Therapeutics, Inc. Wire frame partial flow obstruction for aneurysm treatment
AU8772198A (en) * 1997-08-05 1999-03-08 Target Therapeutics, Inc. Detachable aneurysm neck bridge
US6063070A (en) * 1997-08-05 2000-05-16 Target Therapeutics, Inc. Detachable aneurysm neck bridge (II)
US6168570B1 (en) 1997-12-05 2001-01-02 Micrus Corporation Micro-strand cable with enhanced radiopacity
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6036720A (en) * 1997-12-15 2000-03-14 Target Therapeutics, Inc. Sheet metal aneurysm neck bridge
US6063111A (en) * 1998-03-31 2000-05-16 Cordis Corporation Stent aneurysm treatment system and method
US6168615B1 (en) 1998-05-04 2001-01-02 Micrus Corporation Method and apparatus for occlusion and reinforcement of aneurysms
US6139564A (en) 1998-06-16 2000-10-31 Target Therapeutics Inc. Minimally occlusive flow disruptor stent for bridging aneurysm necks
DK173411B2 (en) * 1998-06-19 2007-04-16 Coloplast As Collection bag for human body secretions
US5935148A (en) * 1998-06-24 1999-08-10 Target Therapeutics, Inc. Detachable, varying flexibility, aneurysm neck bridge
US6656218B1 (en) * 1998-07-24 2003-12-02 Micrus Corporation Intravascular flow modifier and reinforcement device
US6165194A (en) * 1998-07-24 2000-12-26 Micrus Corporation Intravascular flow modifier and reinforcement device
US6093199A (en) * 1998-08-05 2000-07-25 Endovascular Technologies, Inc. Intra-luminal device for treatment of body cavities and lumens and method of use
US7410482B2 (en) 1998-09-04 2008-08-12 Boston Scientific-Scimed, Inc. Detachable aneurysm neck bridge
AU5905599A (en) * 1998-09-04 2000-03-27 Boston Scientific Limited Detachable aneurysm neck closure patch
US6458092B1 (en) 1998-09-30 2002-10-01 C. R. Bard, Inc. Vascular inducing implants
US6432126B1 (en) 1998-09-30 2002-08-13 C.R. Bard, Inc. Flexible vascular inducing implants
US6248112B1 (en) 1998-09-30 2001-06-19 C. R. Bard, Inc. Implant delivery system
WO2000021443A1 (en) * 1998-10-09 2000-04-20 Cook Incorporated Vasoocclusion coil device having a core therein
US6254612B1 (en) * 1998-10-22 2001-07-03 Cordis Neurovascular, Inc. Hydraulic stent deployment system
US6383204B1 (en) 1998-12-15 2002-05-07 Micrus Corporation Variable stiffness coil for vasoocclusive devices
US6692520B1 (en) 1998-12-15 2004-02-17 C. R. Bard, Inc. Systems and methods for imbedded intramuscular implants
US6203779B1 (en) * 1999-03-19 2001-03-20 Charlie Ricci Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
US6620170B1 (en) 1999-04-26 2003-09-16 C. R. Bard, Inc. Devices and methods for treating ischemia by creating a fibrin plug
JP2002543912A (en) * 1999-05-14 2002-12-24 シー・アール・バード・インク Implant mooring system
US20020169473A1 (en) * 1999-06-02 2002-11-14 Concentric Medical, Inc. Devices and methods for treating vascular malformations
US6719805B1 (en) * 1999-06-09 2004-04-13 C. R. Bard, Inc. Devices and methods for treating tissue
US6663607B2 (en) * 1999-07-12 2003-12-16 Scimed Life Systems, Inc. Bioactive aneurysm closure device assembly and kit
US6277082B1 (en) 1999-07-22 2001-08-21 C. R. Bard, Inc. Ischemia detection system
US6709667B1 (en) * 1999-08-23 2004-03-23 Conceptus, Inc. Deployment actuation system for intrafallopian contraception
US6419675B1 (en) * 1999-09-03 2002-07-16 Conmed Corporation Electrosurgical coagulating and cutting instrument
US6602261B2 (en) 1999-10-04 2003-08-05 Microvention, Inc. Filamentous embolic device with expansile elements
US6238403B1 (en) 1999-10-04 2001-05-29 Microvention, Inc. Filamentous embolic device with expansible elements
US6790218B2 (en) * 1999-12-23 2004-09-14 Swaminathan Jayaraman Occlusive coil manufacture and delivery
US20050187564A1 (en) * 1999-12-23 2005-08-25 Swaminathan Jayaraman Occlusive coil manufacturing and delivery
US6632241B1 (en) 2000-03-22 2003-10-14 Endovascular Technologies, Inc. Self-expanding, pseudo-braided intravascular device
US7153323B1 (en) * 2000-06-30 2006-12-26 Boston Scientific Scimed, Inc. Aneurysm liner with multi-segment extender
CA2418299C (en) * 2000-08-11 2009-06-23 Scimed Life Systems, Inc. Variable softness vaso-occlusive coils
US6554849B1 (en) * 2000-09-11 2003-04-29 Cordis Corporation Intravascular embolization device
US7029486B2 (en) * 2000-09-26 2006-04-18 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US6605101B1 (en) * 2000-09-26 2003-08-12 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US6589265B1 (en) 2000-10-31 2003-07-08 Endovascular Technologies, Inc. Intrasaccular embolic device
US6569194B1 (en) 2000-12-28 2003-05-27 Advanced Cardiovascular Systems, Inc. Thermoelastic and superelastic Ni-Ti-W alloy
US7294137B2 (en) * 2001-03-27 2007-11-13 Boston Scientific Scimed Device for multi-modal treatment of vascular lesions
DE10118017B4 (en) * 2001-04-10 2017-04-13 Dendron Gmbh Occlusion coil and device for implantation of occlusion coils
US6616676B2 (en) * 2001-04-10 2003-09-09 Scimed Life Systems, Inc. Devices and methods for removing occlusions in vessels
CA2449055C (en) * 2001-05-29 2010-03-02 Microvention, Inc. Method of manufacturing expansile filamentous embolization devices
US6673106B2 (en) * 2001-06-14 2004-01-06 Cordis Neurovascular, Inc. Intravascular stent device
US7179275B2 (en) * 2001-06-18 2007-02-20 Rex Medical, L.P. Vein filter
US8282668B2 (en) * 2001-06-18 2012-10-09 Rex Medical, L.P. Vein filter
AU2002312441B8 (en) 2001-06-18 2008-08-21 Rex Medical, L.P. Vein Filter
US6793665B2 (en) * 2001-06-18 2004-09-21 Rex Medical, L.P. Multiple access vein filter
US6783538B2 (en) 2001-06-18 2004-08-31 Rex Medical, L.P Removable vein filter
US6623506B2 (en) * 2001-06-18 2003-09-23 Rex Medical, L.P Vein filter
US20030100945A1 (en) 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
US20030014075A1 (en) * 2001-07-16 2003-01-16 Microvention, Inc. Methods, materials and apparatus for deterring or preventing endoleaks following endovascular graft implanation
US8252040B2 (en) 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
US8715312B2 (en) * 2001-07-20 2014-05-06 Microvention, Inc. Aneurysm treatment device and method of use
US7572288B2 (en) * 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
GB0121980D0 (en) 2001-09-11 2001-10-31 Cathnet Science Holding As Expandable stent
US6811560B2 (en) * 2001-09-20 2004-11-02 Cordis Neurovascular, Inc. Stent aneurysm embolization method and device
US6802851B2 (en) * 2001-09-20 2004-10-12 Gordia Neurovascular, Inc. Stent aneurysm embolization method using collapsible member and embolic coils
EP1300120A1 (en) * 2001-10-08 2003-04-09 Jomed Nv Stent delivery system
DE10155191A1 (en) * 2001-11-12 2003-05-22 Dendron Gmbh Medical implant
US20060292206A1 (en) * 2001-11-26 2006-12-28 Kim Steven W Devices and methods for treatment of vascular aneurysms
US7309350B2 (en) 2001-12-03 2007-12-18 Xtent, Inc. Apparatus and methods for deployment of vascular prostheses
US7351255B2 (en) 2001-12-03 2008-04-01 Xtent, Inc. Stent delivery apparatus and method
US7270668B2 (en) * 2001-12-03 2007-09-18 Xtent, Inc. Apparatus and methods for delivering coiled prostheses
US8080048B2 (en) 2001-12-03 2011-12-20 Xtent, Inc. Stent delivery for bifurcated vessels
US20030135266A1 (en) 2001-12-03 2003-07-17 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7182779B2 (en) 2001-12-03 2007-02-27 Xtent, Inc. Apparatus and methods for positioning prostheses for deployment from a catheter
US7137993B2 (en) 2001-12-03 2006-11-21 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7294146B2 (en) 2001-12-03 2007-11-13 Xtent, Inc. Apparatus and methods for delivery of variable length stents
US20040186551A1 (en) 2003-01-17 2004-09-23 Xtent, Inc. Multiple independent nested stent structures and methods for their preparation and deployment
US7892273B2 (en) 2001-12-03 2011-02-22 Xtent, Inc. Custom length stent apparatus
US7147656B2 (en) 2001-12-03 2006-12-12 Xtent, Inc. Apparatus and methods for delivery of braided prostheses
CA2474324C (en) 2002-01-25 2011-09-20 Atritech, Inc. Atrial appendage blood filtration systems
US20050267407A1 (en) * 2002-02-01 2005-12-01 Vascular Designs, Inc. Multi-function catheter and use thereof
JP4597526B2 (en) * 2002-02-01 2010-12-15 ロバート,ジェー. ゴールドマン Multifunctional catheter and method of use thereof
US8062251B2 (en) * 2002-02-01 2011-11-22 Vascular Designs, Inc. Multi-function catheter and use thereof
US6989024B2 (en) 2002-02-28 2006-01-24 Counter Clockwise, Inc. Guidewire loaded stent for delivery through a catheter
US7695488B2 (en) * 2002-03-27 2010-04-13 Boston Scientific Scimed, Inc. Expandable body cavity liner device
US7195648B2 (en) * 2002-05-16 2007-03-27 Cordis Neurovascular, Inc. Intravascular stent device
DE10233085B4 (en) 2002-07-19 2014-02-20 Dendron Gmbh Stent with guide wire
US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US8273100B2 (en) 2002-07-31 2012-09-25 Microvention, Inc. Three element coaxial vaso-occlusive device
US20040044391A1 (en) * 2002-08-29 2004-03-04 Stephen Porter Device for closure of a vascular defect and method of treating the same
WO2004026183A2 (en) 2002-09-20 2004-04-01 Nellix, Inc. Stent-graft with positioning anchor
US7481821B2 (en) * 2002-11-12 2009-01-27 Thomas J. Fogarty Embolization device and a method of using the same
US20050043585A1 (en) * 2003-01-03 2005-02-24 Arindam Datta Reticulated elastomeric matrices, their manufacture and use in implantable devices
US7229454B2 (en) * 2003-01-07 2007-06-12 Boston Scientific Scimed, Inc. Occlusive cinching devices and methods of use
US20040260382A1 (en) 2003-02-12 2004-12-23 Fogarty Thomas J. Intravascular implants and methods of using the same
US6979330B2 (en) * 2003-03-13 2005-12-27 Boston Scientific Scimed, Inc. System for indirectly ablating tissue using implanted electrode devices
US8123774B2 (en) * 2003-03-20 2012-02-28 Boston Scientific Scimed, Inc. Piezoelectric vascular implant release device
US20040193246A1 (en) * 2003-03-25 2004-09-30 Microvention, Inc. Methods and apparatus for treating aneurysms and other vascular defects
US20050209672A1 (en) * 2004-03-02 2005-09-22 Cardiomind, Inc. Sliding restraint stent delivery systems
US7771463B2 (en) 2003-03-26 2010-08-10 Ton Dai T Twist-down implant delivery technologies
ATE467402T1 (en) 2003-03-26 2010-05-15 Cardiomind Inc IMPLANT DEPOSIT CATHETER WITH ELECTROLYTICALLY DEGRADABLE COMPOUNDS
US20040193178A1 (en) 2003-03-26 2004-09-30 Cardiomind, Inc. Multiple joint implant delivery systems for sequentially-controlled implant deployment
US7651513B2 (en) * 2003-04-03 2010-01-26 Boston Scientific Scimed, Inc. Flexible embolic device delivery system
CA2525792C (en) 2003-05-15 2015-10-13 Biomerix Corporation Reticulated elastomeric matrices, their manufacture and use in implantable devices
US7241308B2 (en) 2003-06-09 2007-07-10 Xtent, Inc. Stent deployment systems and methods
US20040260384A1 (en) * 2003-06-17 2004-12-23 Medtronic Ave Superelastic coiled stent
US20050015110A1 (en) * 2003-07-18 2005-01-20 Fogarty Thomas J. Embolization device and a method of using the same
US8043321B2 (en) * 2003-07-24 2011-10-25 Boston Scientific Scimed, Inc. Embolic coil
US7309345B2 (en) * 2003-07-25 2007-12-18 Boston Scientific-Scimed, Inc. Method and system for delivering an implant utilizing a lumen reducing member
US7553324B2 (en) 2003-10-14 2009-06-30 Xtent, Inc. Fixed stent delivery devices and methods
US7232461B2 (en) * 2003-10-29 2007-06-19 Cordis Neurovascular, Inc. Neck covering device for an aneurysm
US7403966B2 (en) * 2003-12-08 2008-07-22 Freescale Semiconductor, Inc. Hardware for performing an arithmetic function
US7326236B2 (en) 2003-12-23 2008-02-05 Xtent, Inc. Devices and methods for controlling and indicating the length of an interventional element
US7763077B2 (en) 2003-12-24 2010-07-27 Biomerix Corporation Repair of spinal annular defects and annulo-nucleoplasty regeneration
DE102004003265A1 (en) 2004-01-21 2005-08-11 Dendron Gmbh Device for the implantation of electrically isolated occlusion coils
US9510929B2 (en) 2004-01-22 2016-12-06 Argon Medical Devices, Inc. Vein filter
US7338512B2 (en) * 2004-01-22 2008-03-04 Rex Medical, L.P. Vein filter
US8062326B2 (en) 2004-01-22 2011-11-22 Rex Medical, L.P. Vein filter
US8500774B2 (en) 2004-01-22 2013-08-06 Rex Medical, L.P. Vein filter
US8211140B2 (en) * 2004-01-22 2012-07-03 Rex Medical, L.P. Vein filter
US8162972B2 (en) 2004-01-22 2012-04-24 Rex Medical, Lp Vein filter
US7976562B2 (en) * 2004-01-22 2011-07-12 Rex Medical, L.P. Method of removing a vein filter
US7704266B2 (en) 2004-01-22 2010-04-27 Rex Medical, L.P. Vein filter
US7876738B2 (en) * 2004-03-02 2011-01-25 Nokia Corporation Preventing an incorrect synchronization between a received code-modulated signal and a replica code
US7651521B2 (en) 2004-03-02 2010-01-26 Cardiomind, Inc. Corewire actuated delivery system with fixed distal stent-carrying extension
US20050209670A1 (en) * 2004-03-02 2005-09-22 Cardiomind, Inc. Stent delivery system with diameter adaptive restraint
US20050209671A1 (en) * 2004-03-02 2005-09-22 Cardiomind, Inc. Corewire actuated delivery system with fixed distal stent-carrying extension
US7323006B2 (en) 2004-03-30 2008-01-29 Xtent, Inc. Rapid exchange interventional devices and methods
US20070190108A1 (en) * 2004-05-17 2007-08-16 Arindam Datta High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair
BRMU8400954Y8 (en) * 2004-05-20 2013-02-19 Language wiper arrangement
EP2419048A4 (en) 2004-05-25 2014-04-09 Covidien Lp Vascular stenting for aneurysms
US8628564B2 (en) 2004-05-25 2014-01-14 Covidien Lp Methods and apparatus for luminal stenting
US8267985B2 (en) 2005-05-25 2012-09-18 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8617234B2 (en) * 2004-05-25 2013-12-31 Covidien Lp Flexible vascular occluding device
US20060206200A1 (en) 2004-05-25 2006-09-14 Chestnut Medical Technologies, Inc. Flexible vascular occluding device
EP1750619B1 (en) 2004-05-25 2013-07-24 Covidien LP Flexible vascular occluding device
US20050288766A1 (en) 2004-06-28 2005-12-29 Xtent, Inc. Devices and methods for controlling expandable prostheses during deployment
US8317859B2 (en) 2004-06-28 2012-11-27 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
WO2006012567A2 (en) 2004-07-22 2006-02-02 Nellix, Inc. Methods and systems for endovascular aneurysm treatment
US8048145B2 (en) 2004-07-22 2011-11-01 Endologix, Inc. Graft systems having filling structures supported by scaffolds and methods for their use
EP1793744B1 (en) * 2004-09-22 2008-12-17 Dendron GmbH Medical implant
CA2581272A1 (en) * 2004-09-22 2006-05-18 Lee R. Guterman Cranial aneurysm treatment arrangement
US8845676B2 (en) 2004-09-22 2014-09-30 Micro Therapeutics Micro-spiral implantation device
CA2580124C (en) * 2004-09-27 2014-05-13 Rex Medical, L.P. Vein filter
US6951571B1 (en) 2004-09-30 2005-10-04 Rohit Srivastava Valve implanting device
US8535345B2 (en) 2004-10-07 2013-09-17 DePuy Synthes Products, LLC Vasoocclusive coil with biplex windings to improve mechanical properties
US20060085057A1 (en) * 2004-10-14 2006-04-20 Cardiomind Delivery guide member based stent anti-jumping technologies
US20060116714A1 (en) * 2004-11-26 2006-06-01 Ivan Sepetka Coupling and release devices and methods for their assembly and use
US8771294B2 (en) 2004-11-26 2014-07-08 Biomerix Corporation Aneurysm treatment devices and methods
US8425550B2 (en) * 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US20060200190A1 (en) * 2005-03-02 2006-09-07 Lorenzo Juan A Embolic coil with twisted wire
US7998164B2 (en) * 2005-03-11 2011-08-16 Boston Scientific Scimed, Inc. Intravascular filter with centering member
US20060206199A1 (en) * 2005-03-12 2006-09-14 Churchwell Stacey D Aneurysm treatment devices
US20060206198A1 (en) * 2005-03-12 2006-09-14 Churchwell Stacey D Aneurysm treatment devices and methods
US20060224175A1 (en) * 2005-03-29 2006-10-05 Vrba Anthony C Methods and apparatuses for disposition of a medical device onto an elongate medical device
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
US7402168B2 (en) 2005-04-11 2008-07-22 Xtent, Inc. Custom-length stent delivery system with independently operable expansion elements
US8273101B2 (en) 2005-05-25 2012-09-25 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
JP4945714B2 (en) 2005-05-25 2012-06-06 タイコ ヘルスケア グループ リミテッド パートナーシップ System and method for supplying and deploying an occlusion device in a conduit
US20070073379A1 (en) * 2005-09-29 2007-03-29 Chang Jean C Stent delivery system
JP2009500121A (en) 2005-07-07 2009-01-08 ネリックス・インコーポレーテッド System and method for treatment of an intraluminal aneurysm
US20070014831A1 (en) * 2005-07-12 2007-01-18 Hsing-Wen Sung Biodegradable occlusive device with moisture memory
US8057495B2 (en) * 2005-09-13 2011-11-15 Cook Medical Technologies Llc Aneurysm occlusion device
US20070073334A1 (en) * 2005-09-29 2007-03-29 Kamal Ramzipoor Combined electrolytic and mechanical separation background
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8545530B2 (en) 2005-10-19 2013-10-01 Pulsar Vascular, Inc. Implantable aneurysm closure systems and methods
BRPI0617652A2 (en) 2005-10-19 2011-08-02 Pulsar Vascular Inc methods and systems for endovascular incision and repair of tissue and lumen defects
US20070100414A1 (en) 2005-11-02 2007-05-03 Cardiomind, Inc. Indirect-release electrolytic implant delivery systems
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US20070150041A1 (en) * 2005-12-22 2007-06-28 Nellix, Inc. Methods and systems for aneurysm treatment using filling structures
WO2007100556A1 (en) 2006-02-22 2007-09-07 Ev3 Inc. Embolic protection systems having radiopaque filter mesh
CA2646885A1 (en) 2006-03-20 2007-09-27 Xtent, Inc. Apparatus and methods for deployment of linked prosthetic segments
US7699884B2 (en) 2006-03-22 2010-04-20 Cardiomind, Inc. Method of stenting with minimal diameter guided delivery systems
US20070239199A1 (en) * 2006-03-31 2007-10-11 Swaminathan Jayaraman Inferior vena cava filter
KR20090008347A (en) 2006-04-17 2009-01-21 마이크로 테라퓨틱스 인코포레이티드 System and method for mechanically positioning intravascular implants
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
US7790273B2 (en) * 2006-05-24 2010-09-07 Nellix, Inc. Material for creating multi-layered films and methods for making the same
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
BRPI0711784B8 (en) 2006-06-15 2021-06-22 Microvention Inc embolization device constructed of expandable polymer and its method of preparation
EP2043531B1 (en) 2006-06-15 2013-01-02 Cook Medical Technologies LLC Systems and devices for the delivery of endoluminal prostheses
US8366720B2 (en) * 2006-07-31 2013-02-05 Codman & Shurtleff, Inc. Interventional medical device system having an elongation retarding portion and method of using the same
US10076401B2 (en) 2006-08-29 2018-09-18 Argon Medical Devices, Inc. Vein filter
US20080269774A1 (en) 2006-10-26 2008-10-30 Chestnut Medical Technologies, Inc. Intracorporeal Grasping Device
WO2008058019A2 (en) * 2006-11-02 2008-05-15 Pakbaz R Sean Devices and methods for accessing and treating an aneurysm
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US8246641B2 (en) * 2006-11-08 2012-08-21 Cook Medical Technolgies, LLC Thrombus removal device
WO2008074027A1 (en) * 2006-12-13 2008-06-19 Biomerix Corporation Aneurysm occlusion devices
CN101605509B (en) * 2006-12-15 2012-09-19 生物传感器国际集团有限公司 Stent systems
US20080166526A1 (en) * 2007-01-08 2008-07-10 Monk Russell A Formed panel structure
US20080199510A1 (en) 2007-02-20 2008-08-21 Xtent, Inc. Thermo-mechanically controlled implants and methods of use
US20080208214A1 (en) * 2007-02-26 2008-08-28 Olympus Medical Systems Corp. Applicator and tissue fastening method through natural orifice
KR20100015521A (en) 2007-03-13 2010-02-12 마이크로 테라퓨틱스 인코포레이티드 An implant, a mandrel, and a method of forming an implant
US8328860B2 (en) 2007-03-13 2012-12-11 Covidien Lp Implant including a coil and a stretch-resistant member
US8486132B2 (en) 2007-03-22 2013-07-16 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US20080255654A1 (en) * 2007-03-22 2008-10-16 Bay Street Medical System for delivering a stent
US20080300667A1 (en) * 2007-05-31 2008-12-04 Bay Street Medical System for delivering a stent
JP5734650B2 (en) 2007-06-25 2015-06-17 マイクロベンション インコーポレイテッド Self-expanding prosthesis
AU2008276344A1 (en) * 2007-07-13 2009-01-22 Stryker Corporation Hybrid and portable power supplies for electrolytically detaching implantable medical devices
CA2694027A1 (en) * 2007-07-20 2009-01-29 Boston Scientific Scimed, Inc. Power supply using time varying signal for electrolytically detaching implantable device
JP5580737B2 (en) 2007-08-17 2014-08-27 ミクラス エンドバスキュラー エルエルシー Twisted primary wind coil for vascular treatment, method for forming the same, and secondary wind coil
US8545514B2 (en) 2008-04-11 2013-10-01 Covidien Lp Monorail neuro-microcatheter for delivery of medical devices to treat stroke, processes and products thereby
US8585713B2 (en) 2007-10-17 2013-11-19 Covidien Lp Expandable tip assembly for thrombus management
US8926680B2 (en) 2007-11-12 2015-01-06 Covidien Lp Aneurysm neck bridging processes with revascularization systems methods and products thereby
US10123803B2 (en) 2007-10-17 2018-11-13 Covidien Lp Methods of managing neurovascular obstructions
US9198687B2 (en) * 2007-10-17 2015-12-01 Covidien Lp Acute stroke revascularization/recanalization systems processes and products thereby
US11337714B2 (en) 2007-10-17 2022-05-24 Covidien Lp Restoring blood flow and clot removal during acute ischemic stroke
US20100174309A1 (en) * 2008-05-19 2010-07-08 Mindframe, Inc. Recanalization/revascularization and embolus addressing systems including expandable tip neuro-microcatheter
US8088140B2 (en) 2008-05-19 2012-01-03 Mindframe, Inc. Blood flow restorative and embolus removal methods
US8066757B2 (en) * 2007-10-17 2011-11-29 Mindframe, Inc. Blood flow restoration and thrombus management methods
US20100256600A1 (en) * 2009-04-04 2010-10-07 Ferrera David A Neurovascular otw pta balloon catheter and delivery system
US9220522B2 (en) 2007-10-17 2015-12-29 Covidien Lp Embolus removal systems with baskets
CA2709379C (en) 2007-12-21 2016-08-16 Microvention, Inc. Hydrogel filaments for biomedical uses
WO2009089297A2 (en) * 2008-01-07 2009-07-16 Intersect Partners, Llc Novel enhanced ptna rapid exchange type of catheter system
US7862538B2 (en) * 2008-02-04 2011-01-04 Incept Llc Surgical delivery system for medical sealant
JP2011511701A (en) * 2008-02-13 2011-04-14 ネリックス・インコーポレーテッド Graft inner frame with axially variable properties
WO2009103125A1 (en) * 2008-02-20 2009-08-27 Neustent Pty Ltd A stent
ES2647310T3 (en) 2008-02-22 2017-12-20 Covidien Lp Device for flow restoration
WO2009105699A1 (en) 2008-02-22 2009-08-27 Endologix, Inc. Design and method of placement of a graft or graft system
US9101503B2 (en) 2008-03-06 2015-08-11 J.W. Medical Systems Ltd. Apparatus having variable strut length and methods of use
EP3970633A1 (en) 2008-04-21 2022-03-23 Covidien LP Braid-ball embolic devices and delivery systems
AU2009240419A1 (en) 2008-04-25 2009-10-29 Nellix, Inc. Stent graft delivery system
US8702746B2 (en) * 2008-04-29 2014-04-22 Cook Medical Technologies Llc Device and method for occlusion of fluid flow through a body vessel
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
US8974487B2 (en) * 2008-05-01 2015-03-10 Aneuclose Llc Aneurysm occlusion device
US9675482B2 (en) * 2008-05-13 2017-06-13 Covidien Lp Braid implant delivery systems
JP2011522615A (en) 2008-06-04 2011-08-04 ネリックス・インコーポレーテッド Sealing device and method of use
US20090319029A1 (en) * 2008-06-04 2009-12-24 Nellix, Inc. Docking apparatus and methods of use
CN102137626A (en) 2008-07-22 2011-07-27 微治疗公司 Vascular remodeling device
ES2879278T3 (en) * 2008-09-05 2021-11-22 Pulsar Vascular Inc Systems to support or occlude a physiological opening or cavity
US11298252B2 (en) 2008-09-25 2022-04-12 Advanced Bifurcation Systems Inc. Stent alignment during treatment of a bifurcation
US8821562B2 (en) 2008-09-25 2014-09-02 Advanced Bifurcation Systems, Inc. Partially crimped stent
AU2009296415B2 (en) 2008-09-25 2015-11-19 Advanced Bifurcation Systems Inc. Partially crimped stent
US8828071B2 (en) 2008-09-25 2014-09-09 Advanced Bifurcation Systems, Inc. Methods and systems for ostial stenting of a bifurcation
WO2010048177A2 (en) * 2008-10-20 2010-04-29 IMDS, Inc. Systems and methods for aneurysm treatment and vessel occlusion
US20100131002A1 (en) * 2008-11-24 2010-05-27 Connor Robert A Stent with a net layer to embolize and aneurysm
WO2010068814A1 (en) 2008-12-10 2010-06-17 Boston Scientific Scimed, Inc. Introducer sheath with an embolic coil device and methods for making the same
CA2750222C (en) * 2009-01-22 2018-02-27 Cornell University Method and apparatus for restricting flow through the wall of a lumen
EP2429452B1 (en) 2009-04-28 2020-01-15 Endologix, Inc. Endoluminal prosthesis system
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
US9579103B2 (en) 2009-05-01 2017-02-28 Endologix, Inc. Percutaneous method and device to treat dissections
US10772717B2 (en) 2009-05-01 2020-09-15 Endologix, Inc. Percutaneous method and device to treat dissections
US20120071911A1 (en) * 2009-05-20 2012-03-22 University Of Miami Spherical helix embolic coils for the treatment of cerebral aneurysms
US8657870B2 (en) 2009-06-26 2014-02-25 Biosensors International Group, Ltd. Implant delivery apparatus and methods with electrolytic release
WO2011003147A1 (en) * 2009-07-09 2011-01-13 Murray Vascular Pty Limited A support device for a tubular structure
JP5731512B2 (en) 2009-09-04 2015-06-10 パルサー バスキュラー インコーポレイテッド System and method for sealing an anatomical opening
JP2013505791A (en) * 2009-09-24 2013-02-21 マイクロベンション インコーポレイテッド Injectable hydrogel fiber for medical use
BR112012009287A2 (en) 2009-10-26 2017-06-06 Microvention Inc embolization device made of expandable polymer
US20110202085A1 (en) 2009-11-09 2011-08-18 Siddharth Loganathan Braid Ball Embolic Device Features
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
US20110276078A1 (en) 2009-12-30 2011-11-10 Nellix, Inc. Filling structure for a graft system and methods of use
US8906057B2 (en) * 2010-01-04 2014-12-09 Aneuclose Llc Aneurysm embolization by rotational accumulation of mass
JP4499831B1 (en) * 2010-01-22 2010-07-07 規方 田熊 Aneurysm embolizer
CN102740799A (en) * 2010-01-28 2012-10-17 泰科保健集团有限合伙公司 Vascular remodeling device
EP2528541B1 (en) * 2010-01-28 2016-05-18 Covidien LP Vascular remodeling device
AU2011232361B2 (en) 2010-03-24 2015-05-28 Advanced Bifurcation Systems Inc. Stent alignment during treatment of a bifurcation
CN103037815B (en) 2010-03-24 2015-05-13 高级分支系统股份有限公司 Methods and systems for treating a bifurcation with provisional side branch stenting
WO2011119884A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc System and methods for treating a bifurcation
US8425548B2 (en) 2010-07-01 2013-04-23 Aneaclose LLC Occluding member expansion and then stent expansion for aneurysm treatment
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US9039749B2 (en) 2010-10-01 2015-05-26 Covidien Lp Methods and apparatuses for flow restoration and implanting members in the human body
EP2635241B1 (en) 2010-11-02 2019-02-20 Endologix, Inc. Apparatus for placement of a graft or graft system
WO2012068298A1 (en) 2010-11-17 2012-05-24 Endologix, Inc. Devices and methods to treat vascular dissections
RU2704539C2 (en) 2011-01-17 2019-10-29 Метэктив Медикал, Инк. Medical device (versions)
US11484318B2 (en) 2011-01-17 2022-11-01 Artio Medical, Inc. Expandable body device and method of use
US8801768B2 (en) 2011-01-21 2014-08-12 Endologix, Inc. Graft systems having semi-permeable filling structures and methods for their use
EP2672932B1 (en) 2011-02-08 2018-09-19 Advanced Bifurcation Systems, Inc. System for treating a bifurcation with a fully crimped stent
CA2826760A1 (en) 2011-02-08 2012-08-16 Advanced Bifurcation Systems, Inc. Multi-stent and multi-balloon apparatus for treating bifurcations and methods of use
AU2012214240B2 (en) 2011-02-11 2015-03-12 Covidien Lp Two-stage deployment aneurysm embolization devices
WO2012112967A1 (en) * 2011-02-18 2012-08-23 Guided Delivery Systems Inc. Systems and methods for variable stiffness tethers
US20120245674A1 (en) 2011-03-25 2012-09-27 Tyco Healthcare Group Lp Vascular remodeling device
WO2012135859A2 (en) * 2011-04-01 2012-10-04 Cornell University Method and apparatus for restricting flow through an opening in the side wall of a body lumen, and/or for reinforcing a weakness in the side wall of a body lumen, while still maintaining substantially normal flow through the body lumen
EP2693980B1 (en) 2011-04-06 2022-07-13 Endologix LLC System for endovascular aneurysm treatment
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
US20120271409A1 (en) * 2011-04-25 2012-10-25 Medtronic Vascular, Inc. Helical Radiopaque Marker
JP2014522263A (en) 2011-05-11 2014-09-04 マイクロベンション インコーポレイテッド Device for occluding a lumen
US9138232B2 (en) 2011-05-24 2015-09-22 Aneuclose Llc Aneurysm occlusion by rotational dispensation of mass
US10004510B2 (en) 2011-06-03 2018-06-26 Pulsar Vascular, Inc. Systems and methods for enclosing an anatomical opening, including shock absorbing aneurysm devices
ES2656328T3 (en) 2011-06-03 2018-02-26 Pulsar Vascular, Inc. Aneurism devices with additional anchoring mechanisms and associated systems
US20120330341A1 (en) 2011-06-22 2012-12-27 Becking Frank P Folded-Flat Aneurysm Embolization Devices
WO2013008204A2 (en) 2011-07-12 2013-01-17 Maestroheart Sa System for tissue marking and treatment
WO2013028998A2 (en) 2011-08-25 2013-02-28 Tyco Health Care Group Lp Systems, devices, and methods for treatment of luminal tissue
US8945171B2 (en) 2011-09-29 2015-02-03 Covidien Lp Delivery system for implantable devices
WO2013049448A1 (en) 2011-09-29 2013-04-04 Covidien Lp Vascular remodeling device
US8795313B2 (en) 2011-09-29 2014-08-05 Covidien Lp Device detachment systems with indicators
EP3735916A1 (en) 2011-10-05 2020-11-11 Pulsar Vascular, Inc. Devices for enclosing an anatomical opening
WO2013055703A1 (en) * 2011-10-07 2013-04-18 Cornell University Method and apparatus for restricting flow through an opening in a body lumen while maintaining normal flow
CA2855003C (en) 2011-11-08 2019-01-15 Boston Scientific Scimed, Inc. Handle assembly for a left atrial appendage occlusion device
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
JP6356612B2 (en) * 2012-01-17 2018-07-11 メタクティブ・メディカル・インコーポレイテッドMetactive Medical, Inc. Expandable device and usage
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
US9259229B2 (en) 2012-05-10 2016-02-16 Pulsar Vascular, Inc. Systems and methods for enclosing an anatomical opening, including coil-tipped aneurysm devices
DE102012010687B4 (en) * 2012-05-30 2021-08-19 ADMEDES GmbH A method for producing a body implant, an assembly comprising a guide wire and a body implant, and a medical instrument
US9155647B2 (en) 2012-07-18 2015-10-13 Covidien Lp Methods and apparatus for luminal stenting
US9326774B2 (en) 2012-08-03 2016-05-03 Covidien Lp Device for implantation of medical devices
WO2014058043A1 (en) 2012-10-12 2014-04-17 日本発條株式会社 Member for implanting in living organism, stent, embolization member, blood vessel expansion kit, and aneurysm embolization kit
US9301831B2 (en) 2012-10-30 2016-04-05 Covidien Lp Methods for attaining a predetermined porosity of a vascular device
US9452070B2 (en) 2012-10-31 2016-09-27 Covidien Lp Methods and systems for increasing a density of a region of a vascular device
US9314248B2 (en) 2012-11-06 2016-04-19 Covidien Lp Multi-pivot thrombectomy device
US9943427B2 (en) 2012-11-06 2018-04-17 Covidien Lp Shaped occluding devices and methods of using the same
US9295571B2 (en) 2013-01-17 2016-03-29 Covidien Lp Methods and apparatus for luminal stenting
US9157174B2 (en) 2013-02-05 2015-10-13 Covidien Lp Vascular device for aneurysm treatment and providing blood flow into a perforator vessel
US9463105B2 (en) 2013-03-14 2016-10-11 Covidien Lp Methods and apparatus for luminal stenting
JP6533776B2 (en) 2013-03-14 2019-06-19 エンドーロジックス インコーポレイテッド System for treating an aneurysm in a patient's body and method of operating the same
CN105142545B (en) 2013-03-15 2018-04-06 柯惠有限合伙公司 Locking device
US10660645B2 (en) 2013-03-15 2020-05-26 Embo Medical Limited Embolization systems
US9907684B2 (en) 2013-05-08 2018-03-06 Aneuclose Llc Method of radially-asymmetric stent expansion
US9844383B2 (en) 2013-05-08 2017-12-19 Embolx, Inc. Devices and methods for low pressure tumor embolization
CN105530986A (en) 2013-05-08 2016-04-27 埃姆博尔克斯公司 Device and methods for transvascular tumor embolization with integrated flow regulation
US10076399B2 (en) 2013-09-13 2018-09-18 Covidien Lp Endovascular device engagement
US9730701B2 (en) 2014-01-16 2017-08-15 Boston Scientific Scimed, Inc. Retrieval wire centering device
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
CN106456836B (en) 2014-04-29 2019-12-06 微仙美国有限公司 Polymers comprising active agents
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
US9808256B2 (en) 2014-08-08 2017-11-07 Covidien Lp Electrolytic detachment elements for implant delivery systems
US9814466B2 (en) 2014-08-08 2017-11-14 Covidien Lp Electrolytic and mechanical detachment for implant delivery systems
CN107530090B (en) 2014-09-17 2021-03-09 阿提奥医疗公司 Expandable body device and method of use
US9717503B2 (en) 2015-05-11 2017-08-01 Covidien Lp Electrolytic detachment for implant delivery systems
US11129737B2 (en) 2015-06-30 2021-09-28 Endologix Llc Locking assembly for coupling guidewire to delivery system
US10307168B2 (en) 2015-08-07 2019-06-04 Terumo Corporation Complex coil and manufacturing techniques
EP3344161B1 (en) * 2015-09-04 2023-12-20 The Texas A&M University System Shape memory polymer vessel occlusion device
US10478194B2 (en) 2015-09-23 2019-11-19 Covidien Lp Occlusive devices
WO2017083660A1 (en) 2015-11-13 2017-05-18 Cardiac Pacemakers, Inc. Bioabsorbable left atrial appendage closure with endothelialization promoting surface
US10350382B1 (en) 2018-06-08 2019-07-16 Embolx, Inc. High torque catheter and methods of manufacture
US9550046B1 (en) 2016-02-16 2017-01-24 Embolx, Inc. Balloon catheter and methods of fabrication and use
US11464948B2 (en) 2016-02-16 2022-10-11 Embolx, Inc. Balloon catheters and methods of manufacture and use
US11517321B2 (en) 2016-05-26 2022-12-06 Nanostructures, Inc. System and methods for embolized occlusion of neurovascular aneurysms
US10828037B2 (en) 2016-06-27 2020-11-10 Covidien Lp Electrolytic detachment with fluid electrical connection
US10828039B2 (en) 2016-06-27 2020-11-10 Covidien Lp Electrolytic detachment for implantable devices
US11051822B2 (en) 2016-06-28 2021-07-06 Covidien Lp Implant detachment with thermal activation
US9848906B1 (en) 2017-06-20 2017-12-26 Joe Michael Eskridge Stent retriever having an expandable fragment guard
JP7013591B2 (en) 2017-12-18 2022-01-31 ボストン サイエンティフィック サイムド,インコーポレイテッド Closure device with expandable members
WO2019144072A1 (en) 2018-01-19 2019-07-25 Boston Scientific Scimed, Inc. Occlusive medical device with delivery system
US11589872B2 (en) 2018-01-31 2023-02-28 Nanostructures, Inc. Vascular occlusion devices utilizing thin film nitinol foils
WO2019213274A1 (en) 2018-05-02 2019-11-07 Boston Scientific Scimed, Inc. Occlusive sealing sensor system
EP3793450A1 (en) 2018-05-15 2021-03-24 Boston Scientific Scimed, Inc. Occlusive medical device with charged polymer coating
US11123079B2 (en) 2018-06-08 2021-09-21 Boston Scientific Scimed, Inc. Occlusive device with actuatable fixation members
US11672541B2 (en) 2018-06-08 2023-06-13 Boston Scientific Scimed, Inc. Medical device with occlusive member
CN112566566A (en) 2018-07-06 2021-03-26 波士顿科学医学有限公司 Closed medical device
US11540838B2 (en) 2019-08-30 2023-01-03 Boston Scientific Scimed, Inc. Left atrial appendage implant with sealing disk
EP4125634A1 (en) 2020-03-24 2023-02-08 Boston Scientific Scimed Inc. Medical system for treating a left atrial appendage

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US497507A (en) 1893-05-16 Alexander wurts
US413970A (en) 1889-10-29 Retaining device for bottle-stoppers
US205512A (en) 1878-07-02 Improvement in razor-strops
US4512338A (en) * 1983-01-25 1985-04-23 Balko Alexander B Process for restoring patency to body vessels
US4878906A (en) * 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
US4739768B2 (en) * 1986-06-02 1995-10-24 Target Therapeutics Inc Catheter for guide-wire tracking
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US5354295A (en) 1990-03-13 1994-10-11 Target Therapeutics, Inc. In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5122136A (en) * 1990-03-13 1992-06-16 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5569245A (en) * 1990-03-13 1996-10-29 The Regents Of The University Of California Detachable endovascular occlusion device activated by alternating electric current
US5221261A (en) * 1990-04-12 1993-06-22 Schneider (Usa) Inc. Radially expandable fixation member
US5344426A (en) 1990-04-25 1994-09-06 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
JPH0447414A (en) 1990-06-13 1992-02-17 Japan Servo Co Ltd Origin position adjusting method for linear actuator
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
NL9101159A (en) 1991-07-03 1993-02-01 Industrial Res Bv FORMATTABLE EXPANDABLE RING, CYLINDER OR SLEEVE.
FR2678508B1 (en) * 1991-07-04 1998-01-30 Celsa Lg DEVICE FOR REINFORCING VESSELS OF THE HUMAN BODY.
US5226911A (en) * 1991-10-02 1993-07-13 Target Therapeutics Vasoocclusion coil with attached fibrous element(s)
CA2380683C (en) 1991-10-28 2006-08-08 Advanced Cardiovascular Systems, Inc. Expandable stents and method for making same
US5261916A (en) * 1991-12-12 1993-11-16 Target Therapeutics Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling
US5258042A (en) 1991-12-16 1993-11-02 Henry Ford Health System Intravascular hydrogel implant
CA2087132A1 (en) 1992-01-31 1993-08-01 Michael S. Williams Stent capable of attachment within a body lumen
ES2086633T3 (en) * 1992-02-03 1996-07-01 Schneider Europ Ag CATHETER WITH A VASCULAR SUPPORT.
US5282823A (en) 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5201757A (en) 1992-04-03 1993-04-13 Schneider (Usa) Inc. Medial region deployment of radially self-expanding stents
US5250071A (en) * 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
US5354294A (en) * 1993-05-26 1994-10-11 Xintec Corporation Combination reflectance fiber optic laser beam angle delivery
US5389106A (en) 1993-10-29 1995-02-14 Numed, Inc. Impermeable expandable intravascular stent
US5476505A (en) 1993-11-18 1995-12-19 Advanced Cardiovascular Systems, Inc. Coiled stent and delivery system
FR2714815B1 (en) * 1994-01-10 1996-03-08 Microfil Ind Sa Elastic prosthesis to widen a duct, in particular a blood vessel.
US5795331A (en) 1994-01-24 1998-08-18 Micro Therapeutics, Inc. Balloon catheter for occluding aneurysms of branch vessels
US5453090A (en) 1994-03-01 1995-09-26 Cordis Corporation Method of stent delivery through an elongate softenable sheath
DE69534194T2 (en) * 1994-03-03 2006-02-16 Boston Scientific Ltd., Barbados DEVICE FOR SEARCHING THE DIVISION IN A VASSOUCHCLUSION DEVICE
WO1995025480A1 (en) 1994-03-18 1995-09-28 Cook Incorporated Helical embolization coil
US5522836A (en) * 1994-06-27 1996-06-04 Target Therapeutics, Inc. Electrolytically severable coil assembly with movable detachment point
US5397355A (en) 1994-07-19 1995-03-14 Stentco, Inc. Intraluminal stent
JP3148819B2 (en) 1995-01-12 2001-03-26 株式会社カネカメディックス Indwelling device
US5609628A (en) * 1995-04-20 1997-03-11 Keranen; Victor J. Intravascular graft and catheter
US5639277A (en) * 1995-04-28 1997-06-17 Target Therapeutics, Inc. Embolic coils with offset helical and twisted helical shapes
US5624461A (en) * 1995-06-06 1997-04-29 Target Therapeutics, Inc. Three dimensional in-filling vaso-occlusive coils
US5582619A (en) * 1995-06-30 1996-12-10 Target Therapeutics, Inc. Stretch resistant vaso-occlusive coils
US6190402B1 (en) 1996-06-21 2001-02-20 Musc Foundation For Research Development Insitu formable and self-forming intravascular flow modifier (IFM) and IFM assembly for deployment of same
US5980514A (en) 1996-07-26 1999-11-09 Target Therapeutics, Inc. Aneurysm closure device assembly
US5951599A (en) 1997-07-09 1999-09-14 Scimed Life Systems, Inc. Occlusion system for endovascular treatment of an aneurysm

Also Published As

Publication number Publication date
ES2202553T3 (en) 2004-04-01
DE69724712D1 (en) 2003-10-16
US5980514A (en) 1999-11-09
CA2211512A1 (en) 1998-01-26
EP0820726A3 (en) 1998-04-15
TW359601B (en) 1999-06-01
DE69724712T2 (en) 2004-07-01
KR980008179A (en) 1998-04-30
JP3205526B2 (en) 2001-09-04
AU709076B2 (en) 1999-08-19
US6344041B1 (en) 2002-02-05
NO973373D0 (en) 1997-07-22
AU3012597A (en) 1998-02-05
US6168592B1 (en) 2001-01-02
JP2001245892A (en) 2001-09-11
EP0820726B1 (en) 2003-09-10
JPH1071154A (en) 1998-03-17
EP0820726A2 (en) 1998-01-28
NO973373L (en) 1998-01-27
ATE249171T1 (en) 2003-09-15

Similar Documents

Publication Publication Date Title
CA2211512C (en) Aneurysm closure device assembly
US6096034A (en) Aneurysm closure device assembly
US6551305B2 (en) Shape memory segmented detachable coil
USRE43311E1 (en) Fast-detaching electrically insulated implant
US6036720A (en) Sheet metal aneurysm neck bridge
US5522836A (en) Electrolytically severable coil assembly with movable detachment point
JP4106178B2 (en) Quick removal electrical insulation implant
EP1003422A1 (en) Detachable aneurysm neck bridge
WO1995025480A1 (en) Helical embolization coil
KR20200115320A (en) Aneurysm treatment device
KR20180103065A (en) Transplantation systems for vascular grafts and vascular grafts using flexible separation zones
JP2007507313A (en) Platform catheter
CN113727671A (en) Micro-macro endovascular occlusion devices and methods
AU4739199A (en) Aneurysm closure device assembly
WO2024035592A1 (en) Delivery devices for treatment of vascular defects

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130725