CA2211100A1 - Diagnostic imaging contrast agents with extended blood retention - Google Patents
Diagnostic imaging contrast agents with extended blood retentionInfo
- Publication number
- CA2211100A1 CA2211100A1 CA002211100A CA2211100A CA2211100A1 CA 2211100 A1 CA2211100 A1 CA 2211100A1 CA 002211100 A CA002211100 A CA 002211100A CA 2211100 A CA2211100 A CA 2211100A CA 2211100 A1 CA2211100 A1 CA 2211100A1
- Authority
- CA
- Canada
- Prior art keywords
- diagnostic imaging
- contrast agents
- blood
- moiety
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/507—Clinical applications involving determination of haemodynamic parameters, e.g. perfusion CT
Abstract
The present invention provides diagnostic imaging contrast agents which exhibit improved blood retention. The novel compounds comprise: a) an image-enhancing (or signal-generating) moiety (IEM); b) a plasma protein binding moiety (PPBM); and c) a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging. These contrast agents exhibit reduced rates of both renal and hepatocellular uptake and no apparent uptake by the RE system. The agents may be targeted to the blood pool or any other biological component. Since the agent is lost less rapidly from the bloodstream, lower doses can be used at a higher margin of safety. The approach is general to both large and small molecules.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002539215A CA2539215A1 (en) | 1995-02-01 | 1996-01-16 | Diagnostic imaging contrast agents with extended blood retention |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38231795A | 1995-02-01 | 1995-02-01 | |
US08/382,317 | 1995-02-01 | ||
PCT/US1996/000164 WO1996023526A2 (en) | 1995-02-01 | 1996-01-16 | Diagnostic imaging contrast agents with extended blood retention |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002539215A Division CA2539215A1 (en) | 1995-02-01 | 1996-01-16 | Diagnostic imaging contrast agents with extended blood retention |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2211100A1 true CA2211100A1 (en) | 1996-08-08 |
CA2211100C CA2211100C (en) | 2007-03-20 |
Family
ID=23508434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002211100A Expired - Lifetime CA2211100C (en) | 1995-02-01 | 1996-01-16 | Diagnostic imaging contrast agents with extended blood retention |
Country Status (25)
Country | Link |
---|---|
US (8) | US6676929B2 (en) |
EP (2) | EP1716871A3 (en) |
JP (4) | JP4064458B2 (en) |
KR (1) | KR100403755B1 (en) |
CN (3) | CN101011586A (en) |
AR (1) | AR006510A1 (en) |
AT (1) | ATE342738T1 (en) |
AU (1) | AU689700B2 (en) |
BR (1) | BR9607136A (en) |
CA (1) | CA2211100C (en) |
DE (3) | DE122006000061I1 (en) |
DK (1) | DK0806968T3 (en) |
ES (1) | ES2274523T3 (en) |
FI (1) | FI973183A (en) |
HK (2) | HK1002551A1 (en) |
IL (1) | IL116847A (en) |
IS (1) | IS2505B (en) |
MY (1) | MY128089A (en) |
NL (1) | NL300253I2 (en) |
NO (2) | NO326114B1 (en) |
NZ (1) | NZ301181A (en) |
PT (1) | PT806968E (en) |
TW (1) | TW319763B (en) |
WO (1) | WO1996023526A2 (en) |
ZA (1) | ZA96417B (en) |
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