CA2210133C - Infusion balloon catheter - Google Patents

Infusion balloon catheter Download PDF

Info

Publication number
CA2210133C
CA2210133C CA002210133A CA2210133A CA2210133C CA 2210133 C CA2210133 C CA 2210133C CA 002210133 A CA002210133 A CA 002210133A CA 2210133 A CA2210133 A CA 2210133A CA 2210133 C CA2210133 C CA 2210133C
Authority
CA
Canada
Prior art keywords
balloon
catheter
guide wire
infusion
proximal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002210133A
Other languages
French (fr)
Other versions
CA2210133A1 (en
Inventor
Rudy J. Kranys
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cordis Corp
Original Assignee
Cordis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cordis Corp filed Critical Cordis Corp
Publication of CA2210133A1 publication Critical patent/CA2210133A1/en
Application granted granted Critical
Publication of CA2210133C publication Critical patent/CA2210133C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/104Balloon catheters used for angioplasty
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M2025/0183Rapid exchange or monorail catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M2025/1043Balloon catheters with special features or adapted for special applications
    • A61M2025/105Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M2025/1043Balloon catheters with special features or adapted for special applications
    • A61M2025/1095Balloon catheters with special features or adapted for special applications with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft

Abstract

Apparatus and method is disclosed relating to a rapid exchange perfusion and infusion balloon catheter for treating a blood vessel with a treatment fluid. A guide catheter allows the balloon catheter to be inserted into the subject and placed near a treatment region within the vascular system. A fluid source is used to selectively inflate an infusion balloon. A guide wire tube having perfusion holes and extending through the balloon allows continuous blood flow while the balloon is inflated. An exit spaced along the guide wire tube allows the infusion balloon catheter to be rapidly exchanged with another infusion balloon catheter without having to remove the guide wire from its position within the subject.

Description

Infusion Balloon Catheter Field of th-e Invention The present invention concerns an infusion balloon catheter having an infusion balloon for delivering a treatment fluid to a treatment site within a subject while allowing blood flow past the infusion balloon.

Background Art Catheterization procedures are well known for diagnosis and treatment of lesions in the cardiovascular system. One such catheterization procedure is known as angioplasty and is used to reduce the damaging effects of vascular plaque blockage or constriction in a subject blood vessel.
In an angioplasty procedure, an expandable balloon is introduced into the patient's arterial system and advanced until it is positioned in the region of the blockage or constriction. Once the balloon is properly positioned, it is expanded by filling it with a liquid. In successful procedures, the expandable balloon presses outwardly against the walls of the artery and expands the artery to increase blood flow.
Infusion catheters are catheters having an infusion balloon designed to deliver a treatment fluid to a treatment site within a blood vessel. The infusion balloon is placed at a subject treatment site in a manner similar to the process of placing a dilation catheter. The infusion balloon has openings in its side wall so that as medication is forced into the balloon from outside the subject it exits the balloon and passes into the blood vessel wall.
An infusion catheter is often used in conjunction with an.angioplasty procedure to re-establish normal blood flow in a blood vessel. The infusion catheter is used to deliver drugs which can prevent restenosis or re-blockage of the blood vessel.
Examples of prior art patents relating to infusion catheters are U.S.
patent 5,087,244 to Wolinsky, U.S. patent 5,232,444 to Just et al., U.S patent 5,049,132 to Shaffer et al., U.S. patent 5,213,576 to Abiuso et al., and U.S.
patent 5,318,531 to Leone. The disclosures of the Abiuso et al and the Leone
2 patents.
The present invention concerns an improved infusion catheter designed to deliver medication into a subject blood vessel while maintaining adequate blood flow through the vessel.
Summarv of the Invention The present invention provides an infusion balloon catheter used in combination with an elongated guide wire for injecting drugs and other substances into a blood vessel of a patient.
In accordance with one embodiment of the present invention, the infusion catheter includes an elongated catheter tube having a lumen for delivering a treatment fluid. A proximal end of the catheter tube remains outside the patient and a distal end is placed at a treatment location within the patient's vascular system.
Attached to the distal end of the elongated catheter tube is an inflatable infusion balloon for receiving the treatment fluid that is injected into the lumen of the catheter tube. Upon inflation of the infusion balloon, the treatment fluid is discharged through the balloon wall and into the patient's blood vessel.
According to the invention, a guide wire tube routes a guide wire through a distal part of the balloon catheter for use in positioning the infusion balloon. The guide wire tube includes a longitudinal portion at its proximal end along the elongated catheter tube that has one or more perfusion holes.
The perfusion holes allow blood to flow through the guide wire tube once the guide wire has been partially withdrawn so that blood flow continues even after the infusion balloon is inflated.
The use of perfusion holes in the guide wire tube allows blood to flow past the inflated infusion balloon, while treatment fluid is being administered.
In the illustrated embodiment the blood actually flows through the inflated infusion balloon.
According to another feature of the invention, the longitudinal portion of the guide wire tube has an exit spaced from a proximal end of the elongated
3 catheter tube that allows rapid exchange of the infusion catheter.
These and other features of the invention will be better understood from a detailed description of alternate embodiments of the invention which are described in conjunction with the accompanying drawings.
Brief Description of the Drawings Figure 1 is a schematic depiction of a guide catheter routing a balloon catheter (either an infusion or a dilation catheter) to a treatment site within a subject blood vessel;
Figure 2 is a schematic depiction of a first embodiment of an infusion catheter constructed in accordance with the present invention;
Figure 3 is an enlarged section view of the first embodiment of an infusion catheter constructed in accordance with the present invention;
Figure 4 is an enlarged cross section view as seen from the plane 4-4 in Fig.3, showing an infusion lumen and stiffening wire lumen;
Figure 5 is an enlarged cross section view as seen from the plane 5-5 in Fig.3, showing an infusion lumen, guide wire tube, and perfusion holes;
Figure 6 is a schematic depiction of a second embodiment of an infusion catheter constructed in accordance with the present invention;
Figure 7 is an enlarged section view of the second embodiment of an infusion catheter constructed in accordance with the present invention; and, Figure 8 is a cross section view as seen from the plane 8-8 in Fig.7, showing an infusion lumen, guide wire tube, and perfusion holes.

Detailed Description of the Preferred Embodiments Figure 1 illustrates use of a guide catheter 10 for positioning a balloon catheter 12 within a subject blood vessel. The guide catheter 10 includes an elongated body having a central passageway 14 that extends from a fitting 16 outside the subject blood vessel through the elongated body and out the distal end 20 of the guide catheter 10. In most applications, the guide catheter 10 is advanced until the guide catheter's distal end 20 reaches a position within the subject's cardiovascular system close to a treatment region. The treatinent
4 region can be the location of a lesion that is to be compressed or can be the location for delivery of a treatment fluid such as heparin. In the former instance a balloon 22 treats the lesion by coming into contact with it and in the latter instance the balloon 22 is only positioned within the blood vessel for delivery of a treatment fluid.
Positioning of the balloon 22 is performed with the aid of a guide wire 26. Before placing the infusion catheter 12 within the guide catheter 10, the guide wire 26 is inserted into and pushed through a guide wire tube 120 at the catheter's distal end (Figure 2) The guidewire's distal tip extends a few centimeters beyond the balloon catheter's distal end. The combination of the guide wire 26, the balloon catheter 12 and its attached balloon 22 are then inserted into the guide catheter 10 until the end of the guide wire 26 exits the guide catheter 10. Both the guide wire 26 and the balloon 22 are pushed forward until the guide wire 26 tip extends beyond the treatment region and the balloon catheter 12 is properly positioned. Positioning of the balloon 22 is facilitated by use of a marker member attached to the catheter that can be viewed on a monitor by an attending physician. The present invention is principally concerned with use of the disclosed embodiments of the invention for delivering a treatment fluid to a treatment region while allowing continued blood flow through the blood vessel being treated.
Figure 2 depicts in greater detail one embodiment of an infusion balloon catheter 110 for injecting a fluid into a subject. The infusion catheter 110 includes an elongated catheter tube 112 for delivering a fluid (such as heparin) to an infusion site within a subject. A lumen 114 for injecting the fluid extends from a proximally located fluid input port 116 to a distal end of the elongated catheter tube 112.
Attached to the distal end of the elongated catheter tube 112 is an inflatable infusion balloon 115. The infusion balloon 115 comprises inner and outer fluid confining balloons 130, 132 that together bridge a fluid delivery region within a blood vessel. A first balloon 130 bounds an inner chamber 140. A center wall portion 142 that bounds the inner chamber 140 has openings or holes 144 spaced along the center wall portion 142. At a'proximal end 134 of the infusion balloon the two balloons 130, 132 overlap an end of the catheter body 112 to form a fluid entryway or opening 146 in fluid communication with the lumen 114 passing through the elongated catheter body 112. Fluid injected into the input port 116 passes through the lumen 114
5 from outside a subject into the inner chamber 140 by means of the entryway 146.
An outer chamber 150 is bounded by an outer wall 152 of the second balloon 132. The outer chamber 150 is bounded by an outer surface of the wall 142 that defines the inner chamber 140. The outer wall 152 includes fluid delivery openings 154 spaced outwardly from a center region of the inner chamber wall 142 that defines the holes or openings 144. Fluid exits the inner chamber to the outer chamber by means of these holes 144, passes through the outer chamber 150 and enters the wall of a blood vessel through the delivery openings 154 in the outer wall 152.
At its distal end the elongated catheter 110 includes a guide wire tube 120 for positioning the catheter within the subject. In the Figure 2 embodiment, the guide wire tube 120 extends completely through the inner chamber 140 and includes distal 122 and proximal ends 124 that open into the blood vessel.
As best shown in Figure 3, a longitudinal portion of the guide wire tube 120 outside the infusion balloon 115 extends alongside the distal end of the elongated catheter tube 112 and includes a number of perfusion holes 128.
The perfusion holes 128, which also extend through a portion of the inner balloon 130, allow continued blood flow through the subject blood vessel while the infusion balloon 115 is inflated, thereby avoiding cut-off of blood flow through the subject vessel.
The guide wire tube 120 defines an exit 126 at its proximal end 124 spaced from the balloon 115 toward a proximal end of the elongated catheter tube 112. The guide wire tube 120 allows for rapid exchange of the catheter with a similar catheter of slightly different dimension without withdrawing the guidewire 26. To exchange catheters, a guidewire 26 is held stationary (the guide wire may have been put in place with some difficulty so it is desirable
6 not to have to withdraw it) and the catheter body 112 is withdrawn over the guidewire 26 until the catheter balloon 115 exits from the guide catheter 10.
A
portion of the guidewire 26 distal to the catheter balloon 115 can then be grasped by an attending physician and an alternate catheter having a similar guide wire tube can be pushed over the guidewire 26 and inserted back into the guide catheter to position the alternate catheter at a treatment site.
As shown in Figure 4 of the drawings, the elongated catheter tube 112 com'nSe,s a pair of lumens; an infusion lumen 114 which routes the inflation fluid into the balloon, and another second lumen 135 which encloses a metal stiffening wire 136 (see Figure 3). The stiffening wire 136 may be fixed in place, typically by fusing, within the catheter body 112. This wire 136 extends from the proximal end of the elongated catheter body 112 to a point just behind the exit 126 through which the guidewire 26 exits the catheter body 112. The second lumen 135 may be closed at its distal end 137 typically by fusing, and at its proximal end by a connector 170 that defines the infusion input port 116. As clearly shown in Figures 3 and 5 depicting the first embodiment, the perfusion holes 128 are in fluid communication with the inner lumen 125 of the guide wire tube 120.
In accordance with practice of the invention, the balloon 115 is positioned within the patient's blood vessel near a treatment location. During this positioning the guidewire 26 extends completely through the guidewire tube 120. Prior to inflating the infusion balloon 115 with the treatment fluid, the guidewire 26 is partially withdrawn from the guide wire tube 120, but not beyond the guide wire tube exit 126. The treatment fluid is injected into the infusion balloon 115 to inflate the infusion balloon 115. The guide wire tube 120 allows blood to pass through the perfusion holes 128 in the wall of the guide wire tube 120, and, because it extends completely through the inflated infusion balloon, allows continuous blood flow through the holes 128 in the sidewall of the tube 120 while the infusion occurs. Subsequent to the infusion treatment, the balloon 115 is deflated and the guidewire 26 pushed through the guidewire tube 120 and out the distal end 122 of the guidewire tube 120. The catheter 110 may then be withdrawn over the guide wire 26 and, if desired,
7 exchanged with another catheter.
Figures 6 - 8 depict a second balloon catheter 210 having a guide wire tube 220'with perfusion holes 228 for allowing continued blood flow with the catheter's distally located balloon inflated.
The second catheter 210 has an elongated body 211 having a single lumen 212 for injecting treatment fluid into a chamber 213 bounded by an inner balloon 214. Treatment fluid passes through a number of openings 215 into a chamber 216 bounded by an outer balloon 217. The outer balloon 217 has openings 218 that deliver the fluid to the blood vessel. A portion of the inner balloon 214 includes perfusion openings 238 that allow blood to pass through to the openings 228 of the guidewire tube 220. Fabrication of the catheter 210 the guide wire tube 220 and the body 211 are fused together to form an oval shape depicted in Figure 8. For the second embodiment depicted in Figures 6-8, the tube 220 has a proximal end 226 that opens into the subject blood vessel without resort to a bend in the tube lumen 230. This second embodiment has a proximal fitting 240 that is connected to the body 211 that defines an inlet port 242. Although no stiffening wire is shown in this second embodiment such a wire could be employed to control the flexibility of the catheter.
Experience with an infusion catheter constructed in accordance with the present invention suggests cer tain ranges of values for the dimensions for lengths of the guide wire tubes 120, 220 that extend proximal to the infusion balloon. A preferred length of the guide wire tube 120, 220 that includes perfusion openings 128, 228 should extend 2 to 3 inches from the guide wire tube exits 126, 226 to the proximal end 134, 234 of the outer balloon 132, 217.
This length will facilitate proper blood perfusion through the guide wire tube 120, 220 with the guide wire 26, 221 still positioned within the proximal end of the guide wire tube 120, 220 to ensure the guide wire 26, 221 can be re-inserted subsequent to infusion.
It has been found through practice of the invention that preferred sizes for the inside diameter of the infusion lumen 114 may typically be about 0.016 to 0.017 inches. For the guide wire tube 120, 220 preferred sizes for the inside
8 diameter may typically be about 0.030 to 0.032 inches, or about twice that of the diameter of the infusion lumen. This preferred guide wire tube 120, 220 diameter "allows for a preferred blood flow rate of about 40 cubic centimeters per minute to be maintained while infusion occurs.
While the present invention has been,described with a degree of particularity, it is the intent that the invention include all modifications and alterations from the disclosed design falling within the spirit and scope of the appended claims.

Claims (15)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
1. A rapid exchange perfusion and infusion balloon catheter for use in combination with an elongated guide wire to infuse drugs and other therapeutic substances into a blood vessel of a patient, comprising:
a) an elongated catheter shaft having a lumen for delivering an inflation fluid;
said catheter shaft including a proximal end that remains outside the patient and a distal end for placement at a treatment location within the patient's vascular system;
b) an inflatable infusion balloon attached to and in fluid communication with the distal end of the elongated catheter shaft for receiving inflation fluid injected into the lumen of the elongated catheter shaft to inflate the infusion balloon, wherein the balloon has a cylindrical inflatable portion and a proximal leg and a distal leg attached to the catheter shaft, said inflatable portion having a plurality of apertures providing fluid communication between an interior of the infusion balloon and the blood vessel of the patient, such that said inflation fluid can be delivered along a flow path directly from the lumen of the catheter shaft, into the infusion balloon, and out through the apertures to infuse a desired site in the blood vessel;
c) a guide wire tube that routes a guide wire through a distal part of the balloon catheter for positioning the infusion balloon; said guide wire tube defining a rapid exchange configuration by having a distal opening at the distal end of the catheter and a proximal opening in communication with an exterior of the catheter shaft, the proximal opening being disposed a relatively short distance proximal from the balloon and a much longer distance distal from the proximal end of the catheter;
d) wherein the guide wire tube further defines a perfusion configuration by a longitudinal perfusion portion near the proximal end of the guide wire tube and extending along the elongated catheter shaft; said longitudinal perfusion portion of the guide wire tube having a plurality of inner perfusion holes to allow blood to flow through the guide wire tube and out the distal opening of the guide wire tube, after the guide wire has been partially withdrawn such that the distal end of the guidewire is disposed proximal from the perfusion holes; and e) wherein the proximal leg of the balloon also has a plurality of outer perfusion holes in positions matching the positions of the inner perfusion holes, thereby enabling the longitudinal perfusion portion of the guidewire tube and the proximal leg of the balloon to overlap.
2. The catheter of claim 1 wherein the apertures are formed as microporous holes spaced along the center of the balloon.
3. The catheter of claim 2 wherein said balloon has a proximal segment attached to a distal portion of the elongated catheter tube and a proximal portion of the guide wire tube.
4. The catheter of claim 3 wherein said balloon has a distal segment attached to a distal portion of the guide wire tube.
5. The catheter of claim 1 where the infusion balloon further comprises an outer balloon attached to and surrounding said infusion balloon, wherein the outer balloon also has a plurality of outer apertures providing fluid communication and allowing infusion of the infusion fluid from within the infusion balloon and out through the outer apertures.
6. The catheter of claim 5 wherein said infusion balloon has a fluid containing lobe at its proximal end and a fluid containing lobe at its distal end, and said lobes are in fluid communication with and are connected by a center section having microporous holes.
7. The catheter of claim 6 wherein said outer balloon is attached to the infusion balloon at the lobes of the infusion balloon, and is spaced from the infusion balloon at said center section, wherein the outer balloon has microporous holes between said fluid containing lobes.
8. The catheter of claim 6 wherein said infusion balloon has a proximal segment attached to a distal portion of the elongated catheter shaft and a proximal portion of the guide wire tube.
9. The catheter of claim 6 wherein said infusion balloon has a distal segment attached to a distal portion of the guide wire tube.
10. The catheter of claim 1 where the infusion balloon comprises an outer sheath attached to an inner balloon.
11. The catheter of claim 10 wherein said infusion balloon has a fluid containing lobe at a proximal end and a fluid containing lobe at a distal end, and said lobes are in fluid communication with and are connected by a center section having microporous holes.
12. The catheter of claim 11 wherein said outer sheath is attached to the infusion balloon at the lobes of the infusion balloon, and is spaced from the infusion balloon at said center section, wherein the outer balloon has microporous holes between said fluid containing lobes.
13. The catheter of claim 11 wherein said infusion balloon has a proximal segment attached to a distal portion of the elongated catheter shaft and a proximal portion of the guide wire tube.
14. The catheter of claim 11 wherein said infusion balloon has a distal segment attached to a distal portion of the guide wire tube.
15. The catheter of claim 1 where the guide wire tube has a larger inside diameter than the outside diameter of a guide wire inserted within the guide wire tube.
CA002210133A 1996-07-10 1997-07-09 Infusion balloon catheter Expired - Lifetime CA2210133C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/678,003 US5833659A (en) 1996-07-10 1996-07-10 Infusion balloon catheter
US08/678,003 1996-07-10

Publications (2)

Publication Number Publication Date
CA2210133A1 CA2210133A1 (en) 1998-01-10
CA2210133C true CA2210133C (en) 2007-10-30

Family

ID=24720978

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002210133A Expired - Lifetime CA2210133C (en) 1996-07-10 1997-07-09 Infusion balloon catheter

Country Status (3)

Country Link
US (1) US5833659A (en)
EP (1) EP0818216A3 (en)
CA (1) CA2210133C (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6280411B1 (en) * 1998-05-18 2001-08-28 Scimed Life Systems, Inc. Localized delivery of drug agents
US6206283B1 (en) * 1998-12-23 2001-03-27 At&T Corp. Method and apparatus for transferring money via a telephone call
US8177743B2 (en) * 1998-05-18 2012-05-15 Boston Scientific Scimed, Inc. Localized delivery of drug agents
US7637886B2 (en) 1999-01-25 2009-12-29 Atrium Medical Corporation Expandable fluoropolymer device and method of making
US6955661B1 (en) 1999-01-25 2005-10-18 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US6569180B1 (en) * 2000-06-02 2003-05-27 Avantec Vascular Corporation Catheter having exchangeable balloon
US7238168B2 (en) * 2000-06-02 2007-07-03 Avantec Vascular Corporation Exchangeable catheter
US20030055377A1 (en) * 2000-06-02 2003-03-20 Avantec Vascular Corporation Exchangeable catheter
US6585926B1 (en) 2000-08-31 2003-07-01 Advanced Cardiovascular Systems, Inc. Method of manufacturing a porous balloon
US6544223B1 (en) * 2001-01-05 2003-04-08 Advanced Cardiovascular Systems, Inc. Balloon catheter for delivering therapeutic agents
US8277868B2 (en) * 2001-01-05 2012-10-02 Abbott Cardiovascular Systems Inc. Balloon catheter for delivering therapeutic agents
US6636758B2 (en) 2001-05-01 2003-10-21 Concentric Medical, Inc. Marker wire and process for using it
US6605154B1 (en) * 2001-05-31 2003-08-12 Advanced Cardiovascular Systems, Inc. Stent mounting device
US6638245B2 (en) 2001-06-26 2003-10-28 Concentric Medical, Inc. Balloon catheter
US6702782B2 (en) 2001-06-26 2004-03-09 Concentric Medical, Inc. Large lumen balloon catheter
US6695920B1 (en) * 2001-06-27 2004-02-24 Advanced Cardiovascular Systems, Inc. Mandrel for supporting a stent and a method of using the mandrel to coat a stent
US6673154B1 (en) * 2001-06-28 2004-01-06 Advanced Cardiovascular Systems, Inc. Stent mounting device to coat a stent
AU2002350164A1 (en) 2001-11-08 2003-05-19 William D. Hare Rapid exchange catheter with stent deployment, therapeutic infusion, and lesion sampling features
US7613503B2 (en) * 2002-08-09 2009-11-03 Boston Scientific Scimed, Inc. Device with infusion holes for imaging inside a blood vessel
US6818063B1 (en) * 2002-09-24 2004-11-16 Advanced Cardiovascular Systems, Inc. Stent mandrel fixture and method for minimizing coating defects
US7335265B1 (en) * 2002-10-08 2008-02-26 Advanced Cardiovascular Systems Inc. Apparatus and method for coating stents
US7074276B1 (en) 2002-12-12 2006-07-11 Advanced Cardiovascular Systems, Inc. Clamp mandrel fixture and a method of using the same to minimize coating defects
US7108684B2 (en) * 2003-01-02 2006-09-19 Novoste Corporation Drug delivery balloon catheter
US7678333B2 (en) * 2003-01-22 2010-03-16 Duoject Medical Systems Inc. Fluid transfer assembly for pharmaceutical delivery system and method for using same
ES2344896T3 (en) * 2003-01-22 2010-09-09 Duoject Medical Systems Inc PHARMACEUTICAL PRODUCT SUPPLY SYSTEMS.
US7354480B1 (en) 2003-02-26 2008-04-08 Advanced Cardiovascular Systems, Inc. Stent mandrel fixture and system for reducing coating defects
US20050015048A1 (en) 2003-03-12 2005-01-20 Chiu Jessica G. Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof
US7250041B2 (en) 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US7323209B1 (en) 2003-05-15 2008-01-29 Advanced Cardiovascular Systems, Inc. Apparatus and method for coating stents
US20040236410A1 (en) * 2003-05-22 2004-11-25 Atrium Medical Corp. Polymeric body formation
US20040236278A1 (en) * 2003-05-22 2004-11-25 Atrium Medical Corp. Therapeutic agent delivery
US20040236279A1 (en) * 2003-05-22 2004-11-25 Atrium Medical Corp. Gaseous therapeutic agent delivery
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
US7022104B2 (en) * 2003-12-08 2006-04-04 Angioscore, Inc. Facilitated balloon catheter exchange
US8042485B1 (en) 2003-12-30 2011-10-25 Advanced Cardiovascular Systems, Inc. Stent mandrel fixture and method for coating stents
US8349388B1 (en) 2004-03-18 2013-01-08 Advanced Cardiovascular Systems, Inc. Method of coating a stent
US20050226991A1 (en) * 2004-04-07 2005-10-13 Hossainy Syed F Methods for modifying balloon of a catheter assembly
US20050267562A1 (en) * 2004-05-13 2005-12-01 Medtronic Vascular, Inc. Stent-reduction sleeve
US7648727B2 (en) 2004-08-26 2010-01-19 Advanced Cardiovascular Systems, Inc. Methods for manufacturing a coated stent-balloon assembly
US7892592B1 (en) 2004-11-30 2011-02-22 Advanced Cardiovascular Systems, Inc. Coating abluminal surfaces of stents and other implantable medical devices
US7823533B2 (en) 2005-06-30 2010-11-02 Advanced Cardiovascular Systems, Inc. Stent fixture and method for reducing coating defects
US7735449B1 (en) 2005-07-28 2010-06-15 Advanced Cardiovascular Systems, Inc. Stent fixture having rounded support structures and method for use thereof
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US7985441B1 (en) 2006-05-04 2011-07-26 Yiwen Tang Purification of polymers for coating applications
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US8287585B2 (en) * 2007-12-26 2012-10-16 The Regents Of The University Of Michigan Ostial stenting system
EP2262566A1 (en) * 2008-03-06 2010-12-22 Boston Scientific Scimed, Inc. Balloon catheter devices with folded balloons
US20110054396A1 (en) * 2009-08-27 2011-03-03 Boston Scientific Scimed, Inc. Balloon Catheter Devices With Drug-Coated Sheath
WO2013171276A1 (en) 2012-05-16 2013-11-21 Endovascular Development AB An assembly with a guide tube, a fixator for attaching to a blood vessel, and a pump
WO2014036530A1 (en) * 2012-08-30 2014-03-06 Celso Bagaoisan Devices and methods for the treatment of vascular disease
US10173030B2 (en) 2013-11-15 2019-01-08 Oakwood Healthcare, Inc. Catheter for infusion of a cardiovascular fluid
US10350395B2 (en) 2017-06-23 2019-07-16 Cook Medical Technologies Llc Introducer for lumen support or dilation
CN111938724A (en) * 2020-08-05 2020-11-17 民勤县人民医院 Obstetric apparatus for pelvic region of obstetrics and gynecology department

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581017B1 (en) * 1983-03-07 1994-05-17 Bard Inc C R Catheter systems
DE3442736A1 (en) * 1984-11-23 1986-06-05 Tassilo Dr.med. 7800 Freiburg Bonzel DILATATION CATHETER
US5040548A (en) * 1989-06-01 1991-08-20 Yock Paul G Angioplasty mehtod
US4944745A (en) * 1988-02-29 1990-07-31 Scimed Life Systems, Inc. Perfusion balloon catheter
DE3821544C2 (en) * 1988-06-25 1994-04-28 H Prof Dr Med Just Dilatation catheter
US5087244A (en) * 1989-01-31 1992-02-11 C. R. Bard, Inc. Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen
US5049132A (en) 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
US5318531A (en) 1991-06-11 1994-06-07 Cordis Corporation Infusion balloon catheter
US5213576A (en) 1991-06-11 1993-05-25 Cordis Corporation Therapeutic porous balloon catheter
WO1993001856A1 (en) * 1991-07-24 1993-02-04 Advanced Cardiovascular Systems, Inc. Low profile perfusion-type dilatation catheter
US5368566A (en) * 1992-04-29 1994-11-29 Cardiovascular Dynamics, Inc. Delivery and temporary stent catheter having a reinforced perfusion lumen
WO1994021320A1 (en) * 1993-03-15 1994-09-29 Advanced Cardiovascular Systems, Inc. Fluid delivery catheter
US5344402A (en) * 1993-06-30 1994-09-06 Cardiovascular Dynamics, Inc. Low profile perfusion catheter
US5792106A (en) * 1993-12-02 1998-08-11 Scimed Life Systems, Inc. In situ stent forming catheter

Also Published As

Publication number Publication date
CA2210133A1 (en) 1998-01-10
EP0818216A3 (en) 1998-03-04
EP0818216A2 (en) 1998-01-14
US5833659A (en) 1998-11-10

Similar Documents

Publication Publication Date Title
CA2210133C (en) Infusion balloon catheter
US9907615B2 (en) Eccentric balloon laser catheter
US6458098B1 (en) Vascular therapy device
US5823996A (en) Infusion balloon catheter
US5370617A (en) Blood perfusion balloon catheter
EP0850660B1 (en) Centering balloon catheter
JP2636504B2 (en) Dilatation catheter with injection lumen
US6309379B1 (en) Sheath for selective delivery of multiple intravascular devices and methods of use thereof
US4892519A (en) Steerable perfusion dilatation catheter
CA2068450C (en) Intravascular device such as introducer sheath or balloon catheter or the like and methods for use
US4909252A (en) Perfusion balloon catheter
US5090960A (en) Regional perfusion dissolution catheter
US5143093A (en) Methods of angioplasty treatment of stenotic regions
US7645260B2 (en) Catheter having auxiliary lumen
US5713854A (en) Method and apparatus for dilatation catheterization
JP4118514B2 (en) Conversion catheter having a single proximal lumen
JPH04215767A (en) Expansion catheter and guide wire
JPH0623055A (en) Catheter apparatus and treatment method using catheter
JPH0538366A (en) Device for forming arterial drainage
IL143534A (en) Endovascular system for the treatment of stenoses of the carotid and catheter for this system
JPH1099444A (en) Vibratory stent to open calcified lesion part
JP2008521536A (en) Drug delivery device
WO2004026387A1 (en) Catheter and guide wire exchange system
JP2000051361A (en) Dilating balloon catheter
JPH05137795A (en) Balloon catheter device for expanding urethra suffering from prostatitis

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170710