CA2206591A1 - Optical techniques for examination of biological tissue - Google Patents

Optical techniques for examination of biological tissue

Info

Publication number
CA2206591A1
CA2206591A1 CA002206591A CA2206591A CA2206591A1 CA 2206591 A1 CA2206591 A1 CA 2206591A1 CA 002206591 A CA002206591 A CA 002206591A CA 2206591 A CA2206591 A CA 2206591A CA 2206591 A1 CA2206591 A1 CA 2206591A1
Authority
CA
Canada
Prior art keywords
radiation
detected
detector
tissue
examination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002206591A
Other languages
French (fr)
Other versions
CA2206591C (en
Inventor
Britton Chance
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Non Invasive Technology Inc
Original Assignee
Non-Invasive Technology, Inc.
Britton Chance
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Non-Invasive Technology, Inc., Britton Chance filed Critical Non-Invasive Technology, Inc.
Publication of CA2206591A1 publication Critical patent/CA2206591A1/en
Application granted granted Critical
Publication of CA2206591C publication Critical patent/CA2206591C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14555—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for the eye fundus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4312—Breast evaluation or disorder diagnosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Abstract

Methods and systems are described that examine tissue (8) positioned between input ports (101, 103) and a detection port (107). At least one source of a visible or infrared wavelength (102, 104) is provided that introduces electromagnetic radiation into the subject. The detection port is optically coupled to a detector (106) that is connected to a detector circuit (101). Radiation intensities are selected for introduction at the input ports to define a null plane (105) in the tissue. The detection port is positioned relative to the null plane. Radiation is introduced into the subject at the first input port and the radiation that migrates through the tissue is detected. The detector circuit stores a first detector signal corresponding to the first detected radiation. Radiation is introduced at the second input port and is detected. The first detector signal is substracted from a second detector signal corresponding to the second detected radiation to obtain processed data.
CA002206591A 1994-12-02 1995-12-04 Optical techniques for examination of biological tissue Expired - Fee Related CA2206591C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/349,018 1994-12-02
US08/349,018 US5673701A (en) 1994-10-07 1994-12-02 Optical techniques for examination of biological tissue
PCT/US1995/015694 WO1996016596A1 (en) 1994-12-02 1995-12-04 Optical techniques for examination of biological tissue

Publications (2)

Publication Number Publication Date
CA2206591A1 true CA2206591A1 (en) 1996-06-06
CA2206591C CA2206591C (en) 2009-09-29

Family

ID=23370544

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002206591A Expired - Fee Related CA2206591C (en) 1994-12-02 1995-12-04 Optical techniques for examination of biological tissue

Country Status (6)

Country Link
US (1) US5673701A (en)
EP (1) EP0796057A4 (en)
JP (1) JP3745775B2 (en)
CN (1) CN1124109C (en)
CA (1) CA2206591C (en)
WO (1) WO1996016596A1 (en)

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Also Published As

Publication number Publication date
CN1170344A (en) 1998-01-14
JPH10510626A (en) 1998-10-13
EP0796057A4 (en) 1999-11-03
JP3745775B2 (en) 2006-02-15
US5673701A (en) 1997-10-07
EP0796057A1 (en) 1997-09-24
WO1996016596A1 (en) 1996-06-06
CA2206591C (en) 2009-09-29
CN1124109C (en) 2003-10-15

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