CA2205553A1 - Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process - Google Patents

Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process

Info

Publication number
CA2205553A1
CA2205553A1 CA002205553A CA2205553A CA2205553A1 CA 2205553 A1 CA2205553 A1 CA 2205553A1 CA 002205553 A CA002205553 A CA 002205553A CA 2205553 A CA2205553 A CA 2205553A CA 2205553 A1 CA2205553 A1 CA 2205553A1
Authority
CA
Canada
Prior art keywords
capsule
caplets
encapsulation
dosage forms
solid dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002205553A
Other languages
French (fr)
Other versions
CA2205553C (en
Inventor
James Amey
Dominique Cade
Paul Maes
Robert Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Capsugel Belgium NV
Original Assignee
Warner-Lambert Company
James Amey
Dominique Cade
Paul Maes
Robert Scott
Warner-Lambert Company Llc
Capsugel Belgium Bvba
Capsugel Belgium Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company, James Amey, Dominique Cade, Paul Maes, Robert Scott, Warner-Lambert Company Llc, Capsugel Belgium Bvba, Capsugel Belgium Nv filed Critical Warner-Lambert Company
Publication of CA2205553A1 publication Critical patent/CA2205553A1/en
Application granted granted Critical
Publication of CA2205553C publication Critical patent/CA2205553C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

Abstract

A process for encapsulation of caplets in a capsule comprises the following steps: a) providing empty capsule parts; b) filling at least one of said capsule parts with one or more caplets; c) putting said capsule parts together, and d) treating the combined parts by cold shrinking. The solid dosage forms obtainable by such a process are tamper-proof in that they cannot be opened in a way to be reassembled without showing such opening process.
CA002205553A 1994-12-16 1995-11-09 Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process Expired - Lifetime CA2205553C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US358,137 1982-03-15
US35813794A 1994-12-16 1994-12-16
PCT/US1995/014651 WO1996018370A1 (en) 1994-12-16 1995-11-09 Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process

Publications (2)

Publication Number Publication Date
CA2205553A1 true CA2205553A1 (en) 1996-06-20
CA2205553C CA2205553C (en) 2009-04-07

Family

ID=23408454

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002205553A Expired - Lifetime CA2205553C (en) 1994-12-16 1995-11-09 Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process

Country Status (14)

Country Link
US (1) US6080426A (en)
EP (1) EP0797424B1 (en)
JP (1) JP3670016B2 (en)
KR (1) KR100468335B1 (en)
CN (1) CN1132566C (en)
AT (1) ATE194486T1 (en)
CA (1) CA2205553C (en)
DE (1) DE69518006T2 (en)
DK (1) DK0797424T3 (en)
ES (1) ES2150017T3 (en)
GR (1) GR3034491T3 (en)
MX (1) MX9703773A (en)
PT (1) PT797424E (en)
WO (1) WO1996018370A1 (en)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2205553C (en) * 1994-12-16 2009-04-07 Warner-Lambert Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US6245350B1 (en) 1994-12-16 2001-06-12 Warner-Lambert Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
FR2757173A1 (en) * 1996-12-17 1998-06-19 Warner Lambert Co POLYMERIC COMPOSITIONS OF NON-ANIMAL ORIGIN FOR FILM FORMATION
US6428809B1 (en) * 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
EP1365745A2 (en) * 2001-02-15 2003-12-03 King Pharmaceuticals, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
US20030072731A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing starch or dextrin
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
US20030070584A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
DE10125883A1 (en) 2001-05-28 2002-12-12 Serumwerk Bernburg Ag Medicines containing an effector of glutathione metabolism together with alpha-lipoic acid in the context of kidney replacement therapy
WO2002098403A1 (en) * 2001-06-01 2002-12-12 Georgetown University Steroid hormone and non-steroidal anti-inflammatory drug combinations for inducing tumor cell apoptosis
ITMI20011401A1 (en) 2001-07-02 2003-01-02 Altergon Sa PHARMACEUTICAL FORMULATIONS FOR THYROID HORMONES
US20030180353A1 (en) * 2001-08-10 2003-09-25 Franz G. Andrew Stabilized pharmaceutical compositions
US20030190349A1 (en) * 2001-08-10 2003-10-09 Franz G. Andrew Methods of stabilizing pharmaceutical compositions
US20030198671A1 (en) * 2001-08-10 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique plasma AUC properties
US20030198667A1 (en) * 2001-08-10 2003-10-23 Franz Andrew G. Methods of producing dispersible pharmaceutical compositions
US20030199587A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique Cmax properties
US20030203967A1 (en) * 2001-08-14 2003-10-30 Franz G. Andrew Levothyroxine compositions having unique Tmax properties
US20030198672A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique triidothyronine plasma AUC properties
US20030199586A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Unique levothyroxine aqueous materials
US20030195253A1 (en) * 2001-08-14 2003-10-16 Franz G. Andrew Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration
US20040253312A1 (en) 2001-09-28 2004-12-16 Sowden Harry S. Immediate release dosage form comprising shell having openings therein
US20040146559A1 (en) * 2002-09-28 2004-07-29 Sowden Harry S. Dosage forms having an inner core and outer shell with different shapes
US8309118B2 (en) * 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US20030181524A1 (en) * 2001-10-29 2003-09-25 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
US20030166732A1 (en) * 2002-02-27 2003-09-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ambroxol for the treatment of painful conditions in the mouth and pharyngeal cavity
US6946156B2 (en) * 2002-05-15 2005-09-20 Mcneil-Ppc, Inc. Process for enrobing a core
US7169450B2 (en) 2002-05-15 2007-01-30 Mcneil-Ppc, Inc. Enrobed core
US7429619B2 (en) * 2002-08-02 2008-09-30 Mcneil Consumer Healthcare Polyacrylic film forming compositions
EP1396263A1 (en) * 2002-08-09 2004-03-10 Warner-Lambert Company Film coating for tablets and caplets
RU2005108576A (en) 2002-09-28 2005-09-20 МакНЕЙЛ-ППС, ИНК. (US) POLYMERIC COMPOSITION AND CONTAINING ITS MEDICINAL FORMS
US20050079213A1 (en) * 2003-06-06 2005-04-14 Unilab Pharmatech Ltd Pharmaceutical compositions
CA2533150C (en) * 2003-07-25 2013-03-12 Warner Chilcott Company, Inc. A doxycycline metal complex in a solid dosage form
ATE354354T1 (en) * 2003-07-30 2007-03-15 Merrion Res I Ltd METHOD AND MACHINE FOR THE AUTOMATIC PRODUCTION OF ENTERIC JUICE RESISTANT CAPSULES
US7879354B2 (en) 2004-01-13 2011-02-01 Mcneil-Ppc, Inc. Rapidly disintegrating gelatinous coated tablets
US8067029B2 (en) * 2004-01-13 2011-11-29 Mcneil-Ppc, Inc. Rapidly disintegrating gelatinous coated tablets
US20050202079A1 (en) * 2004-03-15 2005-09-15 Mylan Pharmaceuticals Inc. Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation
WO2006031584A2 (en) * 2004-09-13 2006-03-23 L. Perrigo Company Quick dissolve medicament and method of manufacturing
JP5235416B2 (en) * 2005-01-21 2013-07-10 ワーナー・チルコット・カンパニー・エルエルシー Tetracycline metal complexes in solid dosage forms.
US20060222699A1 (en) * 2005-03-29 2006-10-05 Jonathan Gilinski Flavored vegetarian cellulose capsule and methods for producing said capsule.
US20070072910A1 (en) * 2005-09-29 2007-03-29 Smith Michael L Compositions and methods for lowering plasma concentrations of low density lipoproteins in humans
DE602007008384D1 (en) * 2006-03-28 2010-09-23 Mcneil Ppc Inc FORM COATINGS WITH INCORRECT DOSAGE
EP2433621B1 (en) 2006-09-15 2013-05-01 Capsugel Belgium NV Rapidly disintegrating dosage form
WO2008042802A2 (en) * 2006-09-29 2008-04-10 Sensient Pharmaceutical Technologies Inc. Wet edible pearlescent film coatings
PL2099312T3 (en) * 2006-12-14 2016-10-31 Pearlescent pigment compositions and methods for making and using the same
MX2009013384A (en) * 2007-06-08 2010-01-25 Addrenex Pharmaceuticals Inc Extended release formulation and method of treating adrenergic dysregulation.
US20100172991A1 (en) * 2007-06-08 2010-07-08 Henry Joseph Horacek Extended Release Formulation and Methods of Treating Adrenergic Dysregulation
US20100092548A1 (en) * 2008-08-28 2010-04-15 Viva Pharmaceuticals Inc. Chewable softgel capsules
CN102300571A (en) * 2008-12-01 2011-12-28 英沃兹科医疗有限公司 Compositions Comprising Renin-angiotensin Aldosterone System Inhibitors And Lipoic Acid Compounds, And The Use Thereof For The Treatment Of Renin-angiotensin Aldosterone System Related Disorders
WO2012024360A2 (en) 2010-08-18 2012-02-23 Mcneil-Ppc, Inc. Tablet sleeve for improved performance
US9119793B1 (en) 2011-06-28 2015-09-01 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for doxycycline
CN102688212B (en) * 2012-05-29 2013-08-07 北京均大高科科技孵化器有限公司 Isosorbide mononitrate sustained release tablet and preparation method thereof
US20140141075A1 (en) 2012-11-21 2014-05-22 Warner Chilcott Company, Llc 5-aminosalicylic acid capsule formulation
US10842802B2 (en) 2013-03-15 2020-11-24 Medicis Pharmaceutical Corporation Controlled release pharmaceutical dosage forms
CN103461335B (en) * 2013-09-26 2015-08-05 卞佳林 A kind of pleocidin and griseofulvin composite microcapsule method for producing insecticide
CN103461336B (en) * 2013-09-26 2015-08-05 卞佳林 A kind of pleocidin and griseofulvin composite microcapsule insecticide
EP3167869A1 (en) 2015-11-16 2017-05-17 Capsugel Belgium NV Tamperproof oral dosage form
EP3167870B1 (en) 2015-11-16 2024-01-03 Capsugel Belgium NV Tamperproof oral dosage form
US11318101B2 (en) 2016-07-06 2022-05-03 Qualicaps Co., Ltd. Hard capsule having improved hardness, and method for manufacturing same
RU2749902C2 (en) * 2018-10-31 2021-06-18 Общество С Ограниченной Ответственностью "Валента-Интеллект" Pharmaceutical composition for treatment of infectious and inflammatory diseases
CN110279890A (en) * 2019-04-15 2019-09-27 首都医科大学附属北京世纪坛医院 Method of modifying and application of the dexamethasone/minocycline based on liposome on the surface PEEK
EP3805577A1 (en) * 2019-10-11 2021-04-14 Hilti Aktiengesellschaft Threadlike package

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US599865A (en) * 1898-03-01 Emanuel l
US724436A (en) * 1902-07-15 1903-04-07 Ernest C Clark Pill-coating machine.
US1520940A (en) * 1922-03-01 1924-12-30 Dulitz August Adolf Process for the manufacture of sealing caps and for applying them onto the vessels to be sealed
US1685392A (en) * 1925-08-12 1928-09-25 Cellacote Company Inc Preservative package and process of making the same
US1657982A (en) * 1926-02-15 1928-01-31 Parke Davis & Co Process of manufacturing gelatin capsules for use as bottle caps
US1774258A (en) * 1929-07-08 1930-08-26 Raymond A English Duplex capsule or the like
US1872190A (en) * 1930-06-07 1932-08-16 Sindl Otto Capsuling machine
US1931765A (en) * 1932-05-09 1933-10-24 Basil E Leever Beverage capsule
US2663130A (en) * 1946-12-26 1953-12-22 American Cyanamid Co Apparatus for producing symmetrical generally ellipsoidal capsules
US3045641A (en) * 1959-04-13 1962-07-24 Pfizer & Co C Apparatus for color-coding tablets
US3228789A (en) * 1962-10-22 1966-01-11 Jacob A Glassman Peroral capsules and tablets and the method for making same
US3185626A (en) * 1963-03-06 1965-05-25 Sterling Drug Inc Tablet coating method
US3258115A (en) * 1965-05-12 1966-06-28 Scherer Corp R P Two-piece hard gelatin capsule
DE2010987C3 (en) * 1970-03-09 1979-03-15 Ibm Deutschland Gmbh, 7000 Stuttgart Method for "making thin film magnetic heads having magnetic anisotropy
US3886940A (en) * 1970-07-10 1975-06-03 Squibb & Sons Inc Capsule
US3896762A (en) * 1973-12-07 1975-07-29 Purdue Research Foundation Coating apparatus
DE2428397C3 (en) * 1974-06-12 1978-05-18 Scherer Hartkapsel Gmbh, 6930 Eberbach Two-part capsule made of hard gelatine
US3983258A (en) * 1975-02-07 1976-09-28 Continental Can Company, Inc. Process of packaging edible products containing exposed bones
US4562024A (en) * 1982-07-06 1985-12-31 Sterling Drug Inc. Process for preparing granulate containing poorly compressible medicinally active matter
JPS59131355A (en) * 1983-01-17 1984-07-28 森下仁丹株式会社 Multiple soft capsule
US4851230A (en) * 1983-04-07 1989-07-25 Bristol-Myers Company Capsule shaped tablets
US4591500A (en) * 1983-04-25 1986-05-27 Microencapsulation S.A. Tablet having the shape of a capsule, process and device for its preparation
US4684516A (en) * 1983-08-01 1987-08-04 Alra Laboratories, Inc. Sustained release tablets and method of making same
AU3188884A (en) * 1983-08-26 1985-03-07 Cosden Technology Inc. Forming tamper-resistant tamper-indicative capsules
US4466844A (en) * 1983-09-19 1984-08-21 Cosden Technology, Inc. Gripper for capsule welder
DE3543154A1 (en) * 1985-12-06 1987-06-11 Boehringer Ingelheim Kg DIVISIBLE CAPSULE
US4928840A (en) * 1986-02-25 1990-05-29 American Home Products Corporation Tamper proof encapsulated medicaments
EP0271627B1 (en) * 1986-10-20 1992-04-15 Paolo Maso Bander machine for drugs containing capsules
US5074426A (en) * 1986-11-13 1991-12-24 Warner-Lambert Company Dividable capsule
US4921108A (en) * 1987-02-20 1990-05-01 Mcneilab, Inc. Apparatus for gelatin coating caplets
US4867983A (en) * 1987-02-20 1989-09-19 Mcneilab, Inc. Method for double dipping gelating coated caplets
US4990358A (en) * 1987-02-20 1991-02-05 Mcneilab, Inc. Method for double dipping gelatin coated caplets
US4820524A (en) * 1987-02-20 1989-04-11 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4966771A (en) * 1987-02-20 1990-10-30 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4844906A (en) * 1987-03-25 1989-07-04 Kv Pharmaceutical Company Tamper evident pharmaceutical capsule
US4973480A (en) * 1987-03-25 1990-11-27 K.V. Pharmaceutical Co. Tamper evident pharmaceutical capsule
US4936074A (en) * 1988-11-17 1990-06-26 D. M. Graham Laboratories, Inc. Process for preparing solid encapsulated medicament
US4965089A (en) * 1989-04-10 1990-10-23 Sauter Manufacturing Corp. Method and apparatus for the gelatin coating of caplets
US5146730A (en) * 1989-09-20 1992-09-15 Banner Gelatin Products Corp. Film-enrobed unitary-core medicament and the like
ES2063317T3 (en) * 1989-12-29 1995-01-01 Bristol Myers Squibb Co COMBINATION OF CAPSULE AND LONG PILL.
US5456919A (en) * 1989-12-29 1995-10-10 Bristol-Myers Squibb Company Capsule and caplet combination
US5198227A (en) * 1990-01-22 1993-03-30 Mcneil-Ppc, Inc. Dual subcoated simulated capsule medicament
US5081822A (en) * 1990-02-01 1992-01-21 Warner-Lambert Company Automatic caplet filler
US5089270A (en) * 1990-05-15 1992-02-18 L. Perrigo Company Capsule-shaped tablet
US5213738A (en) * 1990-05-15 1993-05-25 L. Perrigo Company Method for making a capsule-shaped tablet
US5460824A (en) * 1990-06-27 1995-10-24 Warner-Lambert Company Method for the preparation of an encapsulated medicament
US5188688A (en) * 1990-07-20 1993-02-23 Minnesota Mining And Manufacturing Company Method of sealing a gelatin capsule
US5098715A (en) * 1990-12-20 1992-03-24 Burroughs Wellcome Co. Flavored film-coated tablet
US5114720A (en) * 1990-12-27 1992-05-19 American Cyanamid Company Gelatin coated tablets and method for producing same
US5317849A (en) * 1992-08-07 1994-06-07 Sauter Manufacturing Corporation Encapsulation equipment and method
US5415868A (en) * 1993-06-09 1995-05-16 L. Perrigo Company Caplets with gelatin cover and process for making same
CA2205553C (en) * 1994-12-16 2009-04-07 Warner-Lambert Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
GB0423515D0 (en) * 2004-10-22 2004-11-24 Phoenix Product Dev Ltd A container

Also Published As

Publication number Publication date
CN1170346A (en) 1998-01-14
DE69518006D1 (en) 2000-08-17
EP0797424B1 (en) 2000-07-12
KR100468335B1 (en) 2005-09-02
WO1996018370A1 (en) 1996-06-20
ATE194486T1 (en) 2000-07-15
GR3034491T3 (en) 2000-12-29
CN1132566C (en) 2003-12-31
CA2205553C (en) 2009-04-07
KR980700050A (en) 1998-03-30
ES2150017T3 (en) 2000-11-16
PT797424E (en) 2000-10-31
DK0797424T3 (en) 2000-10-23
EP0797424A1 (en) 1997-10-01
MX9703773A (en) 1997-08-30
JPH11500326A (en) 1999-01-12
US6080426A (en) 2000-06-27
DE69518006T2 (en) 2000-12-21
JP3670016B2 (en) 2005-07-13

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Effective date: 20151109