CA2201611A1 - Saponin preparations and use thereof in iscoms - Google Patents

Saponin preparations and use thereof in iscoms

Info

Publication number
CA2201611A1
CA2201611A1 CA002201611A CA2201611A CA2201611A1 CA 2201611 A1 CA2201611 A1 CA 2201611A1 CA 002201611 A CA002201611 A CA 002201611A CA 2201611 A CA2201611 A CA 2201611A CA 2201611 A1 CA2201611 A1 CA 2201611A1
Authority
CA
Canada
Prior art keywords
iscoms
saponin preparations
saponin
preparations
good
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002201611A
Other languages
French (fr)
Other versions
CA2201611C (en
Inventor
John Cooper Cox
Alan Robert Coulter
Bror Morein
Karin Lovgren-Bengtsson
Bo Sundquist
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iscotec AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2201611A1 publication Critical patent/CA2201611A1/en
Application granted granted Critical
Publication of CA2201611C publication Critical patent/CA2201611C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

Abstract

A preparation of saponins of Quillaja saponaria, comprises fractions of Quil A
having good adjuvant activity, low haemolytic activity and good ability to form immunostimulatory complexes (iscoms).
CA002201611A 1994-10-12 1995-10-12 Saponin preparations and use thereof in iscoms Expired - Lifetime CA2201611C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPM8732 1994-10-12
AUPM8732A AUPM873294A0 (en) 1994-10-12 1994-10-12 Saponin preparations and use thereof in iscoms
PCT/AU1995/000670 WO1996011711A1 (en) 1994-10-12 1995-10-12 Saponin preparations and use thereof in iscoms

Publications (2)

Publication Number Publication Date
CA2201611A1 true CA2201611A1 (en) 1996-04-25
CA2201611C CA2201611C (en) 2004-03-30

Family

ID=3783251

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002201611A Expired - Lifetime CA2201611C (en) 1994-10-12 1995-10-12 Saponin preparations and use thereof in iscoms

Country Status (12)

Country Link
US (1) US6352697B1 (en)
EP (1) EP0785802B1 (en)
JP (1) JPH10508301A (en)
AT (1) ATE210463T1 (en)
AU (1) AUPM873294A0 (en)
CA (1) CA2201611C (en)
DE (1) DE69524624T2 (en)
FI (1) FI971498A (en)
NO (1) NO971622L (en)
NZ (1) NZ293882A (en)
WO (1) WO1996011711A1 (en)
ZA (1) ZA958600B (en)

Families Citing this family (339)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA56132C2 (en) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Vaccine composition (variants), method for stabilizing qs21 providing resistance against hydrolysis (variants), method for manufacturing vaccine
US6231859B1 (en) 1996-12-02 2001-05-15 Aquila Biopharmaceuticals, Inc. Saponin adjuvant compositions
WO1998024319A1 (en) * 1996-12-02 1998-06-11 Aquila Biopharmaceuticals, Inc. Novel saponin compositions and uses thereof
WO1999010008A1 (en) * 1997-08-29 1999-03-04 Aquila Biopharmaceuticals, Inc. Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient
GB9817052D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Biolog Vaccine
EP1104306B1 (en) 1998-08-10 2006-01-11 Antigenics Inc. Compositions of cpg and saponin adjuvants and methods of use thereof
AUPP807399A0 (en) * 1999-01-08 1999-02-04 Csl Limited Improved immunogenic lhrh composition and methods relating thereto
DK2204186T3 (en) 1999-02-17 2016-07-18 Csl Ltd Immunogenic complexes, and related methods
IL145982A0 (en) 1999-04-19 2002-07-25 Smithkline Beecham Biolog Vaccines
US6558670B1 (en) 1999-04-19 2003-05-06 Smithkline Beechman Biologicals S.A. Vaccine adjuvants
US8017590B1 (en) 1999-10-22 2011-09-13 Sanofi Pasteur Limited Method of inducing and/or enhancing an immune response to tumor antigens
DE60039715D1 (en) * 1999-11-19 2008-09-11 Csl Ltd HCV VACCINE COMPOSITIONS
EP1282702B1 (en) 2000-05-10 2006-11-29 Sanofi Pasteur Limited Immunogenic polypeptides encoded by mage minigenes and uses thereof
AUPR011700A0 (en) * 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
PL211151B1 (en) 2000-10-18 2012-04-30 Glaxosmithkline Biolog Sa Vaccines
AU2002254901A1 (en) 2001-02-23 2002-10-03 Smithkline Beecham Biologicals S.A. Influenza vaccine formulations for intradermal delivery
US7713942B2 (en) * 2001-04-04 2010-05-11 Nordic Vaccine Technology A/S Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
AUPR446801A0 (en) 2001-04-18 2001-05-17 University Of Queensland, The Novel compositions and uses therefor
MY134424A (en) 2001-05-30 2007-12-31 Saechsisches Serumwerk Stable influenza virus preparations with low or no amount of thiomersal
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
SE0202110D0 (en) * 2002-07-05 2002-07-05 Isconova Ab Iscom preparation and use thereof
JP4697706B2 (en) 2002-10-11 2011-06-08 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル Polypeptide-vaccine for broad protection against highly virulent meningococcal strains
WO2004037189A2 (en) 2002-10-23 2004-05-06 Glaxosmithkline Biologicals S.A. Methods for vaccinating against malaria
CA3042073C (en) 2003-01-30 2022-09-13 Novartis Vaccines And Diagnostics S.R.L. Injectable vaccines against multiple meningococcal serogroups
SE0300795D0 (en) 2003-03-24 2003-03-24 Isconova Ab Composition comprising iscom particles and live micro-organisms
JP2007537975A (en) 2003-06-10 2007-12-27 ザ ユニバーシティー オブ メルボルン Immunomodulatory compositions, methods for their use and methods for their manufacture
SE0301998D0 (en) * 2003-07-07 2003-07-07 Isconova Ab Quil A fraction with low toxicity and use thereof
WO2005032582A2 (en) 2003-07-31 2005-04-14 Chiron Corporation Immunogenic compositions for streptococcus pyogenes
WO2005033278A2 (en) * 2003-09-30 2005-04-14 Ludwig Institute For Cancer Research In vivo efficacy of ny-eso-1 plus iscom
JP4738339B2 (en) 2003-10-02 2011-08-03 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル Liquid vaccine for multiple meningococcal serogroups
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
EP1682159A4 (en) 2003-10-16 2010-07-21 Stephen John Ralph Immunomodulating compositions and uses therefor
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
EP1722815A1 (en) 2004-03-09 2006-11-22 Chiron Corporation Influenza virus vaccines
EP1740217B1 (en) 2004-04-30 2011-06-15 Novartis Vaccines and Diagnostics S.r.l. Meningococcal conjugate vaccination
GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination
GB0409745D0 (en) 2004-04-30 2004-06-09 Chiron Srl Compositions including unconjugated carrier proteins
GB0410866D0 (en) 2004-05-14 2004-06-16 Chiron Srl Haemophilius influenzae
JP4896021B2 (en) 2004-05-21 2012-03-14 ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド Alphavirus vector for respiratory pathogen vaccine
ATE491467T1 (en) 2004-05-28 2011-01-15 Glaxosmithkline Biolog Sa VACCINE COMPOSITIONS CONTAINING VIROSOMES AND A SAPONIN ADJUVANT
US20090317420A1 (en) 2004-07-29 2009-12-24 Chiron Corporation Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae
GB0417494D0 (en) 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
CA2592627C (en) 2005-01-20 2014-02-25 Isconova Ab Vaccine composition comprising a fibronectin binding protein or a fibronectin binding peptide
GB0502095D0 (en) 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
GB0503337D0 (en) 2005-02-17 2005-03-23 Glaxosmithkline Biolog Sa Compositions
NZ580974A (en) 2005-02-18 2011-05-27 Novartis Vaccines & Diagnostic Immunogens from uropathogenic escherichia coli
NZ561042A (en) 2005-02-18 2011-03-31 Novartis Vaccines & Diagnostic Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli - SEQ ID: 7052
GB0504436D0 (en) 2005-03-03 2005-04-06 Glaxosmithkline Biolog Sa Vaccine
CN101273055B (en) 2005-04-29 2016-03-16 葛兰素史密丝克莱恩生物有限公司 For preventing or treat the novel method of m tuberculosis infection
GB0513421D0 (en) 2005-06-30 2005-08-03 Glaxosmithkline Biolog Sa Vaccines
EP1764369A1 (en) 2005-09-16 2007-03-21 Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH Vaccines comprising truncated HBC core protein plus saponin-based adjuvant
DK179025B1 (en) 2005-09-16 2017-08-28 Intervet Int Bv fish vaccine
CN101355960A (en) 2005-10-18 2009-01-28 诺华疫苗和诊断公司 Mucosal and systemic immunizations with alphavirus replicon particles
EP1779866A1 (en) 2005-11-01 2007-05-02 Intervet International BV Prime-boost vaccine for the protection of equines against viral infection
US10842867B2 (en) 2005-11-04 2020-11-24 Seqirus UK Limited Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture
CA2630220C (en) 2005-11-22 2020-10-13 Doris Coit Norovirus and sapovirus antigens
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
BRPI0707300B8 (en) 2006-01-27 2021-05-25 Novartis Ag split influenza virion vaccine or purified surface antigen and method for preparing an immunogenic composition
CA2646539A1 (en) 2006-03-23 2007-09-27 Novartis Ag Imidazoquinoxaline compounds as immunomodulators
AU2007231027B2 (en) 2006-03-24 2013-10-03 Novartis Influenza Vaccines Marburg Gmbh Storage of influenza vaccines without refrigeration
CA2647942A1 (en) 2006-03-31 2007-11-08 Novartis Ag Combined mucosal and parenteral immunization against hiv
EP2035035A2 (en) 2006-06-09 2009-03-18 Novartis AG Immunogenic compositions for streptococcus agalactiae
GB0614460D0 (en) 2006-07-20 2006-08-30 Novartis Ag Vaccines
EP2586790A3 (en) 2006-08-16 2013-08-14 Novartis AG Immunogens from uropathogenic Escherichia coli
MX2009002408A (en) 2006-09-11 2009-03-20 Novartis Ag Making influenza virus vaccines without using eggs.
WO2008031878A1 (en) * 2006-09-15 2008-03-20 Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH A composition for therapy and/or for prophylaxis of hbv-infections and hbv-mediated diseases
EP1902727A1 (en) * 2006-09-22 2008-03-26 Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH Vaccines comprising truncated HBC core protein plus saponin-based adjuvants
AU2007354917B2 (en) 2006-09-26 2013-06-06 Access To Advanced Health Institute Vaccine composition containing synthetic adjuvant
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
EP2094278B1 (en) * 2006-11-20 2017-04-05 Duecom Use of lipid containing particles comprising quillaja saponins for the treatment of cancer
EP2121011B1 (en) 2006-12-06 2014-05-21 Novartis AG Vaccines including antigen from four strains of influenza virus
GB0700562D0 (en) 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
LT2137210T (en) 2007-03-02 2016-12-27 Glaxosmithkline Biologicals Sa Novel method and compositions
CA2679720A1 (en) * 2007-03-09 2008-09-18 Merck & Co., Inc. Papillomavirus vaccine compositions
CA2688284A1 (en) 2007-05-25 2008-12-04 Novartis Ag Streptococcus pneumoniae pilus antigens
PT2185191E (en) 2007-06-27 2012-11-27 Novartis Ag Low-additive influenza vaccines
GB0713880D0 (en) 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
KR20100068390A (en) 2007-08-13 2010-06-23 글락소스미스클라인 바이오로지칼즈 에스.에이. Vaccines
MX2010002773A (en) 2007-09-12 2010-03-31 Novartis Ag Gas57 mutant antigens and gas57 antibodies.
EP2062594A1 (en) 2007-11-21 2009-05-27 Wyeth Farma, S.A. Bluetongue virus vaccine and immunogenic compositions, methods of use and methods of producing same
GB0810305D0 (en) 2008-06-05 2008-07-09 Novartis Ag Influenza vaccination
GB0818453D0 (en) 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
CN104292312A (en) 2007-12-21 2015-01-21 诺华股份有限公司 Mutant forms of streptolysin o
SI2222710T1 (en) 2007-12-24 2016-11-30 Id Biomedical Corporation Of Quebec Recombinant rsv antigens
EP2231257A4 (en) * 2007-12-24 2013-11-06 Univ Queensland Coating method
CA2749347C (en) * 2008-02-07 2018-03-27 The University Of Queensland Patch production
US9579372B2 (en) 2008-02-21 2017-02-28 Glaxosmithkline Biologicals Sa Meningococcal fHBP polypeptides
CA2718430A1 (en) 2008-03-18 2009-09-24 Novartis Ag Improvements in preparation of influenza virus vaccine antigens
WO2009143524A2 (en) 2008-05-23 2009-11-26 The Regents Of The University Of Michigan Nanoemulsion vaccines
CA2760680A1 (en) * 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents
CN102223876A (en) 2008-09-26 2011-10-19 纳米生物公司 Nanoemulsion therapeutic compositions and methods of using the same
AU2009325950B2 (en) 2008-12-09 2013-03-07 Pfizer Vaccines Llc IgE CH3 peptide vaccine
NZ594029A (en) 2009-01-12 2014-01-31 Novartis Ag Cna_b domain antigens in vaccines against gram positive bacteria
US9265821B2 (en) 2009-02-17 2016-02-23 Glaxosmithkline Biologicals Sa Inactivated dengue virus vaccine with aluminium-free adjuvant
JP2012519482A (en) 2009-03-06 2012-08-30 ノバルティス アーゲー Chlamydia antigen
DK2510947T3 (en) 2009-04-14 2016-03-21 Glaxosmithkline Biolog Sa Compositions for Immunization against Staphylococcus aureus.
WO2010125480A1 (en) 2009-04-30 2010-11-04 Coley Pharmaceutical Group, Inc. Pneumococcal vaccine and uses thereof
MX2011012347A (en) * 2009-05-22 2012-02-21 Genocea Biosciences Inc Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response.
CA2764374C (en) 2009-06-05 2019-11-19 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
CN102802665B (en) 2009-06-15 2015-11-25 新加坡国立大学 Influenza vaccines, compositions and using method
EP2442827B1 (en) 2009-06-16 2016-01-06 The Regents of the University of Michigan Nanoemulsion vaccines
MX2012000036A (en) 2009-06-24 2012-02-28 Glaxosmithkline Biolog Sa Vaccine.
WO2010149745A1 (en) 2009-06-24 2010-12-29 Glaxosmithkline Biologicals S.A. Recombinant rsv antigens
EP2451833B1 (en) 2009-07-07 2018-01-17 GlaxoSmithKline Biologicals SA Conserved escherichia coli immunogens
ES2563730T3 (en) 2009-07-15 2016-03-16 Glaxosmithkline Biologicals S.A. RSV F protein compositions and manufacturing processes thereof
DK2464658T3 (en) 2009-07-16 2014-12-15 Novartis Ag Detoxified escherichia coli immunogens
RU2518291C2 (en) 2009-07-30 2014-06-10 Пфайзер Вэксинс ЭлЭлСи Antigen tau-peptides and their application
US20110076300A1 (en) 2009-08-27 2011-03-31 Mariagrazia Pizza Hybrid Polypeptides Including Meningococcal fHBP Sequences
US20110110980A1 (en) 2009-09-02 2011-05-12 Wyeth Llc Heterlogous prime-boost immunization regimen
CA2771770A1 (en) 2009-09-03 2011-03-10 Pfizer Vaccines Llc Pcsk9 vaccine
WO2011030218A1 (en) 2009-09-10 2011-03-17 Novartis Ag Combination vaccines against respiratory tract diseases
MY157607A (en) * 2009-09-10 2016-06-30 Merial Inc New vaccine formulations comprising saponin-containing adjuvants
DK2477652T3 (en) 2009-09-16 2015-07-20 Vaxart Inc Immunization strategy for the prevention of infection H1Ni
GB0917002D0 (en) 2009-09-28 2009-11-11 Novartis Vaccines Inst For Global Health Srl Improved shigella blebs
GB0917003D0 (en) 2009-09-28 2009-11-11 Novartis Vaccines Inst For Global Health Srl Purification of bacterial vesicles
EP2483390A2 (en) 2009-09-30 2012-08-08 Novartis AG Expression of meningococcal fhbp polypeptides
AU2010352695B2 (en) 2009-09-30 2014-08-21 Glaxosmithkline Biologicals S.A. Conjugation of Staphylococcus aureus type 5 and type 8 capsular polysaccharides
GB0918392D0 (en) 2009-10-20 2009-12-02 Novartis Ag Diagnostic and therapeutic methods
CA2779816A1 (en) 2009-10-27 2011-05-05 Novartis Ag Modified meningococcal fhbp polypeptides
GB0919690D0 (en) 2009-11-10 2009-12-23 Guy S And St Thomas S Nhs Foun compositions for immunising against staphylococcus aureus
CA2785585A1 (en) 2009-12-22 2011-06-30 Celldex Therapeutics, Inc. Vaccine compositions
US9173954B2 (en) 2009-12-30 2015-11-03 Glaxosmithkline Biologicals Sa Polysaccharide immunogens conjugated to E. coli carrier proteins
GB201003333D0 (en) 2010-02-26 2010-04-14 Novartis Ag Immunogenic proteins and compositions
GB201005625D0 (en) 2010-04-01 2010-05-19 Novartis Ag Immunogenic proteins and compositions
CA2796314A1 (en) 2010-04-13 2011-10-20 Novartis Ag Benzonapthyridine compositions and uses thereof
JP2013532008A (en) 2010-05-28 2013-08-15 テトリス オンライン インコーポレイテッド Interactive hybrid asynchronous computer game infrastructure
EP2576613A1 (en) 2010-06-07 2013-04-10 Pfizer Inc. Her-2 peptides and vaccines
CA2800774A1 (en) 2010-06-07 2011-12-15 Pfizer Vaccines Llc Ige ch3 peptide vaccine
GB201009861D0 (en) 2010-06-11 2010-07-21 Novartis Ag OMV vaccines
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
US9192661B2 (en) 2010-07-06 2015-11-24 Novartis Ag Delivery of self-replicating RNA using biodegradable polymer particles
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
EP3272359A1 (en) 2010-07-23 2018-01-24 Novavax AB Influenza vaccine
GB201101665D0 (en) 2011-01-31 2011-03-16 Novartis Ag Immunogenic compositions
CA2808556A1 (en) 2010-09-20 2012-03-29 Crucell Holland B.V. Therapeutic vaccination against active tuberculosis
US9168292B2 (en) 2010-09-27 2015-10-27 Crucell Holland B.V. Heterologous prime boost vaccination regimen against malaria
GB201017519D0 (en) 2010-10-15 2010-12-01 Novartis Vaccines Inst For Global Health S R L Vaccines
JP2013545453A (en) 2010-11-01 2013-12-26 ユニバーシティ・オブ・テクノロジー、シドニー Immunomodulators and their use
WO2012074881A2 (en) * 2010-11-24 2012-06-07 Genocea Biosciences, Inc. Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response
WO2012072769A1 (en) 2010-12-01 2012-06-07 Novartis Ag Pneumococcal rrgb epitopes and clade combinations
EP2655389A2 (en) 2010-12-24 2013-10-30 Novartis AG Compounds
DK2667892T3 (en) 2011-01-26 2019-05-13 Glaxosmithkline Biologicals Sa RSV vaccination program
WO2012131504A1 (en) 2011-03-02 2012-10-04 Pfizer Inc. Pcsk9 vaccine
GB201106357D0 (en) 2011-04-14 2011-06-01 Pessi Antonello Composition and uses thereof
NZ616304A (en) 2011-04-08 2016-01-29 Immune Design Corp Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
HUE034673T2 (en) 2011-05-13 2018-02-28 Glaxosmithkline Biologicals Sa Pre-fusion rsv f antigens
ES2656050T3 (en) 2011-07-06 2018-02-22 Glaxosmithkline Biologicals Sa Immunogenic combination compositions and uses thereof
CA2841047A1 (en) 2011-07-06 2013-01-10 Novartis Ag Immunogenic compositions and uses thereof
BR112014004162A2 (en) 2011-08-22 2018-04-24 Cangene Corp antibodies to clostridium difficile
US9358284B2 (en) 2011-09-14 2016-06-07 Glaxosmithkline Biologicals Sa Methods for making saccharide-protein glycoconjugates
PE20141547A1 (en) 2011-09-16 2014-10-25 Ucb Pharma Sa NEUTRALIZING ANTIBODIES AGAINST THE MAIN EXOTOXINS TCDA AND TCDB OF CLOSTRIDIUM DIFFICILE
EP3311827B1 (en) 2011-10-03 2023-01-04 Canqura Oncology Ab Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
EP2765927B1 (en) 2011-10-12 2021-02-24 Vaxxas Pty Limited Delivery device
CA2854934A1 (en) 2011-11-07 2013-05-16 Novartis Ag Carrier molecule comprising a spr0096 and a spr2021 antigen
US20130122038A1 (en) 2011-11-14 2013-05-16 The United States Of America As Represented By The Secretary Of The Department Heterologous prime-boost immunization using measles virus-based vaccines
WO2013078299A1 (en) * 2011-11-23 2013-05-30 Genocea Biosciences, Inc. Nucleic acid vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response
JP6121436B2 (en) 2011-11-23 2017-04-26 バイオベン・3・リミテッドBioven 3 Limited Recombinant proteins and their therapeutic uses
CA2857087C (en) 2011-11-28 2021-05-25 Crucell Holland B.V. Influenza virus vaccines and uses thereof
WO2013082476A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
WO2013108272A2 (en) 2012-01-20 2013-07-25 International Centre For Genetic Engineering And Biotechnology Blood stage malaria vaccine
TR201908003T4 (en) 2012-02-07 2019-06-21 Infectious Disease Res Inst Advanced adjuvant formulations containing TLR4 agonists and their method of use.
DK2825640T3 (en) 2012-03-12 2016-08-01 Crucell Holland Bv BATCHES OF RECOMBINANT ADENOVIRUS WITH CHANGED TERMINAL END
US8932607B2 (en) 2012-03-12 2015-01-13 Crucell Holland B.V. Batches of recombinant adenovirus with altered terminal ends
CA2867950C (en) 2012-03-22 2023-02-21 Crucell Holland B.V. Vaccine against rsv
US9119813B2 (en) 2012-03-22 2015-09-01 Crucell Holland B.V. Vaccine against RSV
EP2659907A1 (en) 2012-05-01 2013-11-06 Affiris AG Compositions
EP2659908A1 (en) 2012-05-01 2013-11-06 Affiris AG Compositions
EP2659906A1 (en) 2012-05-01 2013-11-06 Affiris AG Compositions
SI2850431T1 (en) 2012-05-16 2018-08-31 Immune Design Corp. Vaccines for hsv-2
ES2820898T3 (en) 2012-05-22 2021-04-22 Glaxosmithkline Biologicals Sa Meningococcal serogroup X conjugate
EP2666785A1 (en) 2012-05-23 2013-11-27 Affiris AG Complement component C5a-based vaccine
JP2015522580A (en) 2012-07-06 2015-08-06 ノバルティス アーゲー Immunological compositions and uses thereof
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
JP2015525794A (en) 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Method for eliciting an immune response against RSV and Bordetella pertussis in infants
EP2703483A1 (en) 2012-08-29 2014-03-05 Affiris AG PCSK9 peptide vaccine
WO2014043189A1 (en) 2012-09-14 2014-03-20 The Regents Of The University Of Colorado, A Body Corporate Conditionally replication deficient herpes viruses and use thereof in vaccines
EP4056198A3 (en) 2012-09-18 2022-12-07 GlaxoSmithKline Biologicals SA Outer membrane vesicles
EP2903650B1 (en) 2012-10-02 2018-04-04 GlaxoSmithKline Biologicals SA Nonlinear saccharide conjugates
WO2014053612A1 (en) 2012-10-03 2014-04-10 Novartis Ag Immunogenic composition
PE20151720A1 (en) 2013-03-08 2015-12-10 Crucell Holland Bv ACELLULAR VACCINE AGAINST PERTUSSIS
MY187936A (en) 2013-03-15 2021-10-29 In3Bio Ltd Self-assembling synthetic proteins
TW201502136A (en) 2013-03-15 2015-01-16 Glaxosmithkline Biolog Sa Vaccine
WO2014163558A1 (en) 2013-04-01 2014-10-09 Moreinx Ab Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
EA032326B1 (en) 2013-04-18 2019-05-31 Иммьюн Дизайн Корп. Gla monotherapy for use in cancer treatment
EA039803B1 (en) 2013-04-25 2022-03-15 Янссен Вэксинс Энд Превеншн Б.В. Stabilized soluble prefusion rsv f polypeptides
WO2014191435A1 (en) 2013-05-30 2014-12-04 Crucell Holland B.V. Influenza virus vaccines and uses thereof
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
CA2914792C (en) 2013-06-17 2024-02-27 Crucell Holland B.V. Stabilized soluble pre-fusion rsv f polypeptides
WO2015000832A1 (en) 2013-07-02 2015-01-08 Crucell Holland B.V. Method for preparing virosomes
WO2015000831A1 (en) 2013-07-02 2015-01-08 Crucell Holland B.V. Method for preparing virosomes
EP3492097A1 (en) 2013-08-05 2019-06-05 GlaxoSmithKline Biologicals S.A. Combination immunogenic compositions
WO2015063611A2 (en) 2013-11-01 2015-05-07 University Of Oslo Albumin variants and uses thereof
DK3069138T3 (en) 2013-11-15 2019-04-08 Univ Oslo Hf CTL PEPTID EPITOPES AND ANTIGEN-SPECIFIC T-CELLS, METHODS OF RECOGNITION THEREOF, AND APPLICATIONS THEREOF
WO2015092710A1 (en) 2013-12-19 2015-06-25 Glaxosmithkline Biologicals, S.A. Contralateral co-administration of vaccines
BR112016015422A2 (en) 2013-12-31 2017-10-24 Infectious Disease Res Inst single vial vaccine formulations
NZ759686A (en) 2014-01-21 2023-07-28 Pfizer Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
US11160855B2 (en) 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
US20170065702A1 (en) 2014-02-19 2017-03-09 Cangene Corporation Methods of modulating an immune response
US20170224805A1 (en) 2014-02-20 2017-08-10 Vaxart, Inc. Formulations for small intestinal delivery
BR112016022011A2 (en) 2014-03-26 2017-10-24 Glaxosmithkline Biologicals Sa ? mutant staphylococcal protein antigen, fusion protein, and immunogenic composition?
AU2015243246B2 (en) 2014-04-10 2018-09-06 Obi Pharma Inc. Antibodies, pharmaceutical compositions and uses thereof
MX2016016533A (en) 2014-06-13 2017-05-01 Glaxosmithkline Biologicals Sa Immunogenic combinations.
TW201623329A (en) 2014-06-30 2016-07-01 亞佛瑞司股份有限公司 Vaccines and monoclonal antibodies targeting truncated variants of osteopontin and uses thereof
PE20170290A1 (en) 2014-07-10 2017-03-26 Janssen Vaccines And Prevention B V VACCINES AGAINST INFLUENZA VIRUSES AND USES OF THEM
WO2016011386A1 (en) 2014-07-18 2016-01-21 University Of Washington Cancer vaccine compositions and methods of use thereof
JP7158853B2 (en) 2014-10-10 2022-10-24 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン An immunogenic composition for treating food or respiratory allergies in a subject and for intranasal administration to said subject
AU2015341926B2 (en) 2014-11-04 2018-09-27 Janssen Vaccines & Prevention B.V. Therapeutic HPV16 vaccines
KR102149760B1 (en) 2015-01-15 2020-08-31 화이자 인코포레이티드 Immunogenic composition for use in pneumococcal vaccine
EP3253440B1 (en) 2015-02-02 2022-12-21 Vaxxas Pty Limited Microprojection array applicator
CA2977493C (en) 2015-03-03 2023-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Display platform from bacterial spore coat proteins
WO2016141320A2 (en) 2015-03-05 2016-09-09 Northwestern University Non-neuroinvasive viruses and uses thereof
AU2016249798B2 (en) 2015-04-14 2022-05-26 Janssen Vaccines And Prevention B.V. Recombinant adenovirus expressing two transgenes with a bidirectional promoter
JP2018521016A (en) 2015-06-03 2018-08-02 アフィリス・アクチェンゲゼルシャフトAffiris Ag IL-23-p19 vaccine
AU2016274599B2 (en) 2015-06-12 2021-09-02 Vaxart, Inc. Formulations for small intestinal delivery of RSV and norovirus antigens
EP3319634B1 (en) 2015-07-07 2019-08-21 Janssen Vaccines & Prevention B.V. Stabilized soluble pre-fusion rsv f polypeptides
DK3319633T3 (en) 2015-07-07 2021-02-01 Janssen Vaccines & Prevention Bv VACCINE MOD RSV
CA2991544A1 (en) 2015-07-07 2017-01-12 Affiris Ag Vaccines for the treatment and prevention of ige mediated diseases
TWI756893B (en) 2015-07-21 2022-03-01 美商輝瑞股份有限公司 Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof
AU2016309743B2 (en) 2015-08-20 2019-02-07 Janssen Vaccines & Prevention B.V. Therapeutic HPV18 vaccines
JP6975709B2 (en) 2015-09-02 2021-12-01 ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. Stabilized virus class I fusion protein
SG10201913145SA (en) 2015-09-03 2020-02-27 Novavax Inc Vaccine compositions having improved stability and immunogenicity
AR105910A1 (en) 2015-09-04 2017-11-22 Obi Pharma Inc GLICAN MATRICES AND METHOD OF USE
CN116063481A (en) 2015-09-04 2023-05-05 普里玛托普医疗股份有限公司 Humanized anti-CD 40 antibodies and uses thereof
EP3138579A1 (en) 2015-09-05 2017-03-08 Biomay Ag Fusion protein for use in the treatment of a hepatitis b virus infection
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US10786561B2 (en) 2015-11-20 2020-09-29 Pfizer Inc. Immunogenic compositions for use in pneumococcal vaccines
EP3393512A1 (en) 2015-12-23 2018-10-31 Pfizer Inc Rsv f protein mutants
WO2017158421A1 (en) 2016-03-14 2017-09-21 University Of Oslo Anti-viral engineered immunoglobulins
TN2018000301A1 (en) 2016-03-14 2020-01-16 Univ Oslo Engineered immunoglobulins with altered fcrn binding
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
TWI780045B (en) 2016-03-29 2022-10-11 台灣浩鼎生技股份有限公司 Antibodies, pharmaceutical compositions and methods
AU2017248021B2 (en) 2016-04-05 2021-08-12 Janssen Vaccines & Prevention B.V. Stabilized soluble pre-fusion RSV F proteins
AU2017248018A1 (en) 2016-04-05 2018-09-27 Janssen Vaccines & Prevention B.V. Vaccine against RSV
KR20230110820A (en) 2016-04-22 2023-07-25 오비아이 파머 인코퍼레이티드 Cancer immunotherapy by immune activation or immune modulation via globo series antigens
CN109922829A (en) 2016-05-02 2019-06-21 扬森疫苗与预防公司 Therapeutic HPV vaccine combination
US11173207B2 (en) 2016-05-19 2021-11-16 The Regents Of The University Of Michigan Adjuvant compositions
MX2018014699A (en) 2016-05-30 2019-02-28 Janssen Vaccines & Prevention Bv Stabilized pre-fusion rsv f proteins.
WO2017207477A1 (en) 2016-05-30 2017-12-07 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv f proteins
JP6683847B2 (en) 2016-06-20 2020-04-22 ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. Strong and balanced bidirectional promoter
WO2017221072A2 (en) 2016-06-21 2017-12-28 University Of Oslo Hla binding vaccine moieties and uses thereof
EP3484506A1 (en) 2016-07-14 2019-05-22 Janssen Vaccines & Prevention B.V. Hpv vaccines
WO2018018082A1 (en) 2016-07-26 2018-02-01 The Australian National University Immunostimulatory compositions and uses therefor
CA3032049C (en) 2016-07-27 2023-11-07 Obi Pharma, Inc. Immunogenic/therapeutic glycan compositions and uses thereof
EP3491026A4 (en) 2016-07-29 2020-07-29 OBI Pharma, Inc. Human antibodies, pharmaceutical compositions and methods
WO2018037045A1 (en) 2016-08-23 2018-03-01 Glaxosmithkline Biologicals Sa Fusion peptides with antigens linked to short fragments of invariant chain (cd74)
GB201614799D0 (en) 2016-09-01 2016-10-19 Glaxosmithkline Biologicals Sa Compositions
EP3295956A1 (en) 2016-09-20 2018-03-21 Biomay Ag Polypeptide construct comprising fragments of allergens
US10350288B2 (en) 2016-09-28 2019-07-16 Genocea Biosciences, Inc. Methods and compositions for treating herpes
BE1024774B1 (en) 2016-09-29 2018-07-02 Glaxosmithkline Biologicals Sa COMPOSITIONS AND METHODS OF TREATMENT
GB201616904D0 (en) 2016-10-05 2016-11-16 Glaxosmithkline Biologicals Sa Vaccine
EP3541414A4 (en) 2016-11-21 2020-11-11 OBI Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
GB201620968D0 (en) 2016-12-09 2017-01-25 Glaxosmithkline Biologicals Sa Adenovirus polynucleotides and polypeptides
MX2019006349A (en) 2016-12-16 2019-08-22 Inst Res Biomedicine Novel recombinant prefusion rsv f proteins and uses thereof.
EP3570879B1 (en) 2017-01-20 2022-03-30 Pfizer Inc. Immunogenic compositions for use in pneumococcal vaccines
AU2018217935B2 (en) 2017-02-09 2020-04-30 Janssen Vaccines & Prevention B.V. Potent and short promoter for expression of heterologous genes
US11123419B2 (en) 2017-03-15 2021-09-21 Novavax, Inc. Methods and compositions for inducing immune responses against Clostridium difficile
DK3606760T3 (en) 2017-03-31 2023-11-06 Vaxxas Pty Ltd ARRANGEMENT AND PROCEDURE FOR COATING SURFACES
SG11201909265QA (en) 2017-04-19 2019-11-28 Inst Res Biomedicine Plasmodium sporozoite npdp peptides as vaccine and target novel malaria vaccines and antibodies binding to
AU2018267971A1 (en) 2017-05-17 2019-11-07 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against RSV infection
WO2018227246A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
IL300235A (en) 2017-07-18 2023-03-01 In3Bio Ltd Synthetic proteins and therapeutic uses thereof
CN111148509A (en) 2017-07-24 2020-05-12 诺瓦瓦克斯股份有限公司 Methods and compositions for treating respiratory disorders
EP3661587A4 (en) 2017-08-04 2021-06-09 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
US20220118076A1 (en) 2017-09-07 2022-04-21 University Of Oslo Vaccine molecules
EP3678699A1 (en) 2017-09-07 2020-07-15 University Of Oslo Vaccine molecules
US20200276299A1 (en) 2017-09-08 2020-09-03 Infectious Disease Research Institute Liposomal formulations comprising saponin and methods of use
WO2019053109A1 (en) 2017-09-15 2019-03-21 Janssen Vaccines & Prevention B.V. Method for the safe induction of immunity against rsv
GB201721069D0 (en) 2017-12-15 2018-01-31 Glaxosmithkline Biologicals Sa Hepatitis B Immunisation regimen and compositions
GB201721068D0 (en) 2017-12-15 2018-01-31 Glaxosmithkline Biologicals Sa Hepatitis B immunisation regimen and compositions
PT3743106T (en) 2018-01-23 2022-08-24 Janssen Vaccines & Prevention Bv Influenza virus vaccines and uses thereof
WO2019173438A1 (en) 2018-03-06 2019-09-12 Stc. Unm Compositions and methods for reducing serum triglycerides
MX2020009682A (en) * 2018-03-19 2020-10-12 Novavax Inc Multivalent influenza nanoparticle vaccines.
GB201807303D0 (en) 2018-05-03 2018-06-20 London School Of Hygeine & Tropical Medicine Glyconjugate vaccines
EP3569612A1 (en) 2018-05-18 2019-11-20 Biomay Ag Treatment and prevention of house dust mite allergies
WO2019224275A1 (en) 2018-05-23 2019-11-28 Adc Therapeutics Sa Molecular adjuvant
MX2020013553A (en) 2018-06-12 2021-02-26 Glaxosmithkline Biologicals Sa Adenovirus polynucleotides and polypeptides.
EP3581201A1 (en) 2018-06-15 2019-12-18 GlaxoSmithKline Biologicals S.A. Escherichia coli o157:h7 proteins and uses thereof
WO2020006176A1 (en) 2018-06-27 2020-01-02 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use
MX2021001479A (en) 2018-08-07 2021-04-28 Glaxosmithkline Biologicals Sa Processes and vaccines.
JP2021534761A (en) 2018-08-23 2021-12-16 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Immunogenic proteins and compositions
US11260119B2 (en) 2018-08-24 2022-03-01 Pfizer Inc. Escherichia coli compositions and methods thereof
JP2022513025A (en) 2018-11-13 2022-02-07 ヤンセン ファッシンズ アンド プリベンション ベーフェー Stabilized pre-fusion RSVF protein
US20220016229A1 (en) 2018-12-12 2022-01-20 Pfizer Inc. Immunogenic Multiple Hetero-Antigen Polysaccharide-Protein Conjugates and uses thereof
WO2020128012A1 (en) 2018-12-21 2020-06-25 Glaxosmithkline Biologicals Sa Methods of inducing an immune response
TW202102256A (en) 2019-03-05 2021-01-16 比利時商葛蘭素史密斯克藍生物品公司 Hepatitis b immunisation regimen and compositions
CA3136278A1 (en) 2019-04-10 2020-10-15 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof
KR20220005002A (en) 2019-04-25 2022-01-12 얀센 백신스 앤드 프리벤션 비.브이. Recombinant Influenza Antigen
MX2021013947A (en) 2019-05-15 2021-12-14 Janssen Vaccines & Prevention Bv Prophylactic treatment of respiratory syncytial virus infection with an adenovirus based vaccine.
JP2022532723A (en) 2019-05-15 2022-07-19 ヤンセン ファッシンズ アンド プリベンション ベーフェー Co-administration of seasonal influenza vaccine and adenovirus-based respiratory syncytial virus vaccine
WO2020243115A1 (en) 2019-05-25 2020-12-03 Infectious Disease Research Institute Composition and method for spray drying an adjuvant vaccine emulsion
KR20220058527A (en) 2019-06-25 2022-05-09 인3바이오 리미티드 Stabilized chimeric synthetic protein and its therapeutic use
AU2020318680A1 (en) 2019-07-21 2022-02-17 Glaxosmithkline Biologicals Sa Therapeutic viral vaccine
JP2022547107A (en) 2019-09-05 2022-11-10 ヤンセン ファッシンズ アンド プリベンション ベーフェー Influenza virus vaccine and its use
WO2021084429A1 (en) 2019-11-01 2021-05-06 Pfizer Inc. Escherichia coli compositions and methods thereof
WO2021097347A1 (en) 2019-11-15 2021-05-20 Infectious Disease Research Institute Rig-i agonist and adjuvant formulation for tumor treatment
US10953089B1 (en) 2020-01-27 2021-03-23 Novavax, Inc. Coronavirus vaccine formulations
TW202204380A (en) 2020-01-31 2022-02-01 美商詹森藥物公司 Compositions and methods for preventing and treating coronavirus infection - sars-cov-2 vaccines
JP2023514697A (en) 2020-02-23 2023-04-07 ファイザー・インク E. coli composition and method
WO2021229448A1 (en) 2020-05-11 2021-11-18 Janssen Pharmaceuticals, Inc. Rna replicon encoding a stabilized corona virus spike protein
CA3183086A1 (en) 2020-05-11 2021-11-18 Janssen Pharmaceuticals, Inc. Stabilized coronavirus spike protein fusion proteins
CN115884786A (en) 2020-05-11 2023-03-31 杨森制药公司 SARS-CoV-2 vaccine
WO2021245611A1 (en) 2020-06-05 2021-12-09 Glaxosmithkline Biologicals Sa Modified betacoronavirus spike proteins
BR112022026408A2 (en) 2020-06-29 2023-01-17 Janssen Vaccines & Prevention Bv VACCINE COMBINATION AGAINST RESPIRATORY SYNCYTIAL VIRUS INFECTION
BR112022026974A2 (en) 2020-07-06 2023-01-24 Janssen Pharmaceuticals Inc STABILIZED FUSION PROTEINS OF CORONAVIRUS PEAK PROTEINS
JP2022060169A (en) 2020-10-02 2022-04-14 ファイザー・インク Cell culture process for rsv f protein production
KR20230096033A (en) 2020-10-27 2023-06-29 화이자 인코포레이티드 Escherichia coli composition and method thereof
CN116744965A (en) 2020-11-04 2023-09-12 辉瑞大药厂 Immunogenic compositions for pneumococcal vaccines
MX2023006320A (en) 2020-12-02 2023-06-14 Glaxosmithkline Biologicals Sa Donor strand complemented fimh.
US20220202923A1 (en) 2020-12-23 2022-06-30 Pfizer Inc. E. coli fimh mutants and uses thereof
WO2022147373A1 (en) 2020-12-31 2022-07-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody-guided pcsk9-mimicking immunogens lacking 9-residue sequence overlap with human proteins
EP4032547A1 (en) 2021-01-20 2022-07-27 GlaxoSmithKline Biologicals S.A. Hsv1 fce derived fragements for the treatment of hsv
WO2022175479A1 (en) 2021-02-19 2022-08-25 Janssen Vaccines & Prevention B.V. Vaccine combinations against respiratory syncytial virus strain a and b infections
KR20230147156A (en) 2021-02-19 2023-10-20 얀센 백신스 앤드 프리벤션 비.브이. Stabilized pre-fusion RSV FB antigen
GB202102396D0 (en) 2021-02-19 2021-04-07 Adc Therapeutics Sa Molecular adjuvant
CN117320745A (en) 2021-03-30 2023-12-29 维拉瓦克斯股份公司 SARS-COV-2 subunit vaccine
WO2022207793A1 (en) 2021-03-31 2022-10-06 Vib Vzw Vaccine compositions for trypanosomatids
WO2022207839A2 (en) 2021-04-01 2022-10-06 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion piv3 f proteins
WO2023020939A1 (en) 2021-08-17 2023-02-23 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
WO2023046898A1 (en) 2021-09-23 2023-03-30 Viravaxx AG Hbv vaccine inducing pres-specific neutralizing antibodies
WO2023047348A1 (en) 2021-09-24 2023-03-30 Janssen Pharmaceuticals, Inc. Stabilized corona virus spike protein fusion proteins
WO2023047349A1 (en) 2021-09-24 2023-03-30 Janssen Pharmaceuticals, Inc. Stabilized coronavirus spike protein fusion proteins
WO2023079529A1 (en) 2021-11-05 2023-05-11 King Abdullah University Of Science And Technology Re-focusing protein booster immunization compositions and methods of use thereof
WO2023079528A1 (en) 2021-11-05 2023-05-11 King Abdullah University Of Science And Technology Compositions suitable for use in a method for eliciting cross-protective immunity against coronaviruses
WO2023114727A1 (en) 2021-12-13 2023-06-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bacteriophage lambda-vaccine system
WO2023111725A1 (en) 2021-12-14 2023-06-22 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
WO2023110618A1 (en) 2021-12-16 2023-06-22 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion hmpv fusion proteins
WO2023196634A2 (en) 2022-04-08 2023-10-12 Flagship Pioneering Innovations Vii, Llc Vaccines and related methods
WO2023217988A1 (en) 2022-05-12 2023-11-16 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion hmpv fusion proteins
WO2024017682A1 (en) 2022-07-18 2024-01-25 Janssen Vaccines & Prevention B.V. Rsv immunogens
US20240042021A1 (en) 2022-08-01 2024-02-08 Flagship Pioneering Innovations Vii, Llc Immunomodulatory proteins and related methods
WO2024061757A1 (en) 2022-09-23 2024-03-28 Janssen Vaccines & Prevention B.V. Pre-fusion human piv1 f proteins
WO2024061759A1 (en) 2022-09-23 2024-03-28 Janssen Vaccines & Prevention B.V. Stabilized coronavirus s proteins
WO2024061753A1 (en) 2022-09-23 2024-03-28 Janssen Vaccines & Prevention B.V. Stabilized trimeric class i fusion proteins
WO2024074584A1 (en) 2022-10-06 2024-04-11 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion piv3 f proteins

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583112A (en) * 1987-05-29 1996-12-10 Cambridge Biotech Corporation Saponin-antigen conjugates and the use thereof
CA1331443C (en) 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
NZ230747A (en) 1988-09-30 1992-05-26 Bror Morein Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
NL9002314A (en) * 1990-10-23 1992-05-18 Nederlanden Staat IMMUNOGENE COMPLEXES, IN PARTICULAR ISCOMS.
US5273965A (en) 1992-07-02 1993-12-28 Cambridge Biotech Corporation Methods for enhancing drug delivery with modified saponins
WO1995009179A1 (en) 1993-09-30 1995-04-06 Seed Capital Investments (Sci) B.V. Compounds with adjuvant activity

Also Published As

Publication number Publication date
EP0785802B1 (en) 2001-12-12
WO1996011711A1 (en) 1996-04-25
EP0785802A4 (en) 1998-11-04
NZ293882A (en) 1999-02-25
EP0785802A1 (en) 1997-07-30
DE69524624T2 (en) 2002-05-16
ATE210463T1 (en) 2001-12-15
NO971622L (en) 1997-06-10
FI971498A0 (en) 1997-04-10
JPH10508301A (en) 1998-08-18
FI971498A (en) 1997-06-10
US6352697B1 (en) 2002-03-05
NO971622D0 (en) 1997-04-09
ZA958600B (en) 1997-04-14
AUPM873294A0 (en) 1994-11-03
DE69524624D1 (en) 2002-01-24
CA2201611C (en) 2004-03-30

Similar Documents

Publication Publication Date Title
CA2201611A1 (en) Saponin preparations and use thereof in iscoms
DE3268367D1 (en) Anthracycline glycoside compositions, their use and preparation
CA2144676A1 (en) Solid Lipophilic Composition and Process for Its Preparation
IE852593L (en) Compositions containing anthracycline glycosides
AU2764592A (en) Beta -1,3-glucan polysaccharides, compositions, and their preparation and uses
AU608056B2 (en) Thickened aqueous surfactant solutions, more especially for use in cosmetic preparations
EP0236677A3 (en) Oxo-derived mild surfactant blends
AU5561690A (en) Improvements in or relating to pharmaceutical preparations
AU7955087A (en) Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use thereof
AU6820087A (en) Amine oxide and use as surfactant in detergent compositions
IL82820A0 (en) Anthracycline glycosides,their preparation and pharmaceutical compositions containing them
AU1748592A (en) Sulfate polysaccharides, preparation method, pharmaceutical composition and utilization
AU8251287A (en) Surfactants in acid-peptized catalyst compositions
IL72168A0 (en) Preparation of 6-deoxy-anthracyclines,anthracycline glycosides prepared therefrom and their preparation
AU8089287A (en) Anionic cyclodiylide compounds, their preparation and use in washing agents as shading dyes
AU7533487A (en) Through-the-wash fabric conditioning compositions
AU2613697A (en) 1-C-perfluoroalkyl glycosides, preparation process and uses thereof
AU7528087A (en) Immunogenic fraction active against bilharzioses, its preparation, and immunizing compositions containing it
AU3627695A (en) Use of retinoid glycosides in topical pharmaceutical compositions
AU6837190A (en) Sulfonated propylphenylphosphines, their preparation and use
EP1121937A4 (en) Vaccine preparations containing saponins
AU3644495A (en) Saponin preparations and use thereof in iscoms
AU5006490A (en) Azole-1-alkanamides as antiarrhythmic agents and preparation thereof
HU9201115D0 (en) Alchemilla-extract, process for its preparation, and cosmetical preparations made of alchemilla extract
AU7239987A (en) Anti-cold kit, anti-cold preparation and use thereof

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20151013