CA2200061A1 - Container with multi-phase composition for use in diagnostic and therapeutic applications - Google Patents
Container with multi-phase composition for use in diagnostic and therapeutic applicationsInfo
- Publication number
- CA2200061A1 CA2200061A1 CA002200061A CA2200061A CA2200061A1 CA 2200061 A1 CA2200061 A1 CA 2200061A1 CA 002200061 A CA002200061 A CA 002200061A CA 2200061 A CA2200061 A CA 2200061A CA 2200061 A1 CA2200061 A1 CA 2200061A1
- Authority
- CA
- Canada
- Prior art keywords
- container
- therapeutic applications
- diagnostic
- phase composition
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 238000002059 diagnostic imaging Methods 0.000 abstract 1
- 239000007792 gaseous phase Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000012285 ultrasound imaging Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
- A61K8/70—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine containing perfluoro groups, e.g. perfluoroethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3145—Filters incorporated in syringes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Abstract
A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/307,305 US5773024A (en) | 1989-12-22 | 1994-09-16 | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US08/307,305 | 1994-11-29 | ||
PCT/US1995/009392 WO1996008234A1 (en) | 1994-09-16 | 1995-07-26 | Container with multi-phase composition for use in diagnostic and therapeutic applications |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2200061A1 true CA2200061A1 (en) | 1996-03-21 |
CA2200061C CA2200061C (en) | 2007-04-10 |
Family
ID=23189144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002200061A Expired - Lifetime CA2200061C (en) | 1994-09-16 | 1995-07-26 | Container with multi-phase composition for use in diagnostic and therapeutic applications |
Country Status (14)
Country | Link |
---|---|
US (1) | US5773024A (en) |
EP (2) | EP0788348B1 (en) |
JP (1) | JP4004063B2 (en) |
CN (1) | CN1098068C (en) |
AT (2) | ATE270878T1 (en) |
AU (1) | AU708341B2 (en) |
BR (1) | BR9509011B1 (en) |
CA (1) | CA2200061C (en) |
DE (2) | DE69533261T2 (en) |
DK (2) | DK0788348T3 (en) |
ES (2) | ES2225844T3 (en) |
MX (1) | MX9701969A (en) |
PT (2) | PT1588699E (en) |
WO (1) | WO1996008234A1 (en) |
Families Citing this family (75)
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US6088613A (en) * | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5656211A (en) * | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
US5776429A (en) * | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US5798091A (en) | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
US5545396A (en) | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
US6743779B1 (en) * | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
BR9711082A (en) * | 1996-03-29 | 2000-01-11 | Lawrence Berkeley National Lab | Enhancement of rmn emri in the presence of hyperpolarized soft gases. |
ATE345682T1 (en) * | 1996-05-01 | 2006-12-15 | Imarx Pharmaceutical Corp | IN VITRO METHOD FOR INTRODUCING NUCLEIC ACIDS INTO A CELL |
KR100593873B1 (en) * | 1996-08-02 | 2006-07-03 | 지이 헬스케어 에이에스 | Improvements in or relating to contrast agent |
GB9617811D0 (en) | 1996-08-27 | 1996-10-09 | Nycomed Imaging As | Improvements in or relating to contrast agents |
NZ335265A (en) | 1996-10-21 | 2000-07-28 | Nycomed Imaging As | Gas containing contrast agents that may be co-administered with vasodilator drugs to enhance differences in return signal intensity from normal and hypoperfused myocardial tissue contrast agents |
US6537246B1 (en) * | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
GB9708240D0 (en) * | 1997-04-23 | 1997-06-11 | Nycomed Imaging As | Improvements in or relating to contrast agents |
US6416740B1 (en) * | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
GB9717589D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
US20010003580A1 (en) * | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
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US6523356B2 (en) | 1998-09-30 | 2003-02-25 | Medi-Physics, Inc. | Meted hyperpolarized noble gas dispensing methods and associated devices |
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US7061237B2 (en) * | 2000-07-13 | 2006-06-13 | The Regents Of The University Of California | Remote NMR/MRI detection of laser polarized gases |
US20030165431A1 (en) * | 2000-07-13 | 2003-09-04 | The Regents Of The University Of California | Method for detecting macromolecular conformational change and binding information |
US6652833B2 (en) * | 2000-07-13 | 2003-11-25 | The Regents Of The University Of California | Functionalized active-nucleus complex sensor |
US6793626B2 (en) | 2001-01-17 | 2004-09-21 | Fuji Photo Film Co., Ltd. | Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus |
US7138104B2 (en) * | 2001-08-08 | 2006-11-21 | Bristol-Myers Squibb Company | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
US6838074B2 (en) | 2001-08-08 | 2005-01-04 | Bristol-Myers Squibb Company | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
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US7700074B2 (en) * | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
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1994
- 1994-09-16 US US08/307,305 patent/US5773024A/en not_active Expired - Lifetime
-
1995
- 1995-07-26 JP JP51017496A patent/JP4004063B2/en not_active Expired - Lifetime
- 1995-07-26 DE DE69533261T patent/DE69533261T2/en not_active Expired - Lifetime
- 1995-07-26 PT PT04076135T patent/PT1588699E/en unknown
- 1995-07-26 DK DK95927429T patent/DK0788348T3/en active
- 1995-07-26 AU AU31465/95A patent/AU708341B2/en not_active Expired
- 1995-07-26 CA CA002200061A patent/CA2200061C/en not_active Expired - Lifetime
- 1995-07-26 PT PT95927429T patent/PT788348E/en unknown
- 1995-07-26 ES ES95927429T patent/ES2225844T3/en not_active Expired - Lifetime
- 1995-07-26 DK DK04076135.5T patent/DK1588699T3/en active
- 1995-07-26 AT AT95927429T patent/ATE270878T1/en not_active IP Right Cessation
- 1995-07-26 ES ES04076135T patent/ES2335206T3/en not_active Expired - Lifetime
- 1995-07-26 EP EP95927429A patent/EP0788348B1/en not_active Expired - Lifetime
- 1995-07-26 CN CN95195094A patent/CN1098068C/en not_active Expired - Lifetime
- 1995-07-26 BR BRPI9509011-8A patent/BR9509011B1/en not_active IP Right Cessation
- 1995-07-26 AT AT04076135T patent/ATE445390T1/en active
- 1995-07-26 EP EP04076135A patent/EP1588699B1/en not_active Expired - Lifetime
- 1995-07-26 WO PCT/US1995/009392 patent/WO1996008234A1/en active IP Right Grant
- 1995-07-26 DE DE69536012T patent/DE69536012D1/en not_active Expired - Lifetime
- 1995-07-26 MX MX9701969A patent/MX9701969A/en unknown
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WO1996008234A1 (en) | 1996-03-21 |
CA2200061C (en) | 2007-04-10 |
AU3146595A (en) | 1996-03-29 |
ES2335206T3 (en) | 2010-03-23 |
MX9701969A (en) | 1998-02-28 |
EP0788348A1 (en) | 1997-08-13 |
AU708341B2 (en) | 1999-08-05 |
EP1588699A2 (en) | 2005-10-26 |
EP1588699A3 (en) | 2006-01-18 |
EP1588699B1 (en) | 2009-10-14 |
US5773024A (en) | 1998-06-30 |
ES2225844T3 (en) | 2005-03-16 |
EP0788348B1 (en) | 2004-07-14 |
BR9509011B1 (en) | 2009-01-13 |
JP4004063B2 (en) | 2007-11-07 |
DE69536012D1 (en) | 2009-11-26 |
DE69533261D1 (en) | 2004-08-19 |
CN1158082A (en) | 1997-08-27 |
PT1588699E (en) | 2010-01-19 |
DK0788348T3 (en) | 2004-11-29 |
DE69533261T2 (en) | 2005-08-04 |
ATE270878T1 (en) | 2004-07-15 |
BR9509011A (en) | 1997-09-30 |
PT788348E (en) | 2004-09-30 |
JPH10505900A (en) | 1998-06-09 |
CN1098068C (en) | 2003-01-08 |
ATE445390T1 (en) | 2009-10-15 |
DK1588699T3 (en) | 2010-03-01 |
EP0788348A4 (en) | 1998-04-01 |
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