CA2199515A1 - Automated molecular biological diagnostic system - Google Patents

Automated molecular biological diagnostic system

Info

Publication number
CA2199515A1
CA2199515A1 CA002199515A CA2199515A CA2199515A1 CA 2199515 A1 CA2199515 A1 CA 2199515A1 CA 002199515 A CA002199515 A CA 002199515A CA 2199515 A CA2199515 A CA 2199515A CA 2199515 A1 CA2199515 A1 CA 2199515A1
Authority
CA
Canada
Prior art keywords
dna
interface
self
electrical connections
diagnostic system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002199515A
Other languages
French (fr)
Other versions
CA2199515C (en
Inventor
Michael J. Heller
Eugene Tu
Donald D. Montgomery
William F. Butler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanogen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2199515A1 publication Critical patent/CA2199515A1/en
Application granted granted Critical
Publication of CA2199515C publication Critical patent/CA2199515C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • G11C13/0009—RRAM elements whose operation depends upon chemical change
    • G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
    • G11C13/0019—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material comprising bio-molecules
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Abstract

Self-addressable, self-assembling microelectronic system for performing molecular diagnosis, analysis, multi-step and multiplex reactions in microscopic formats. Actively controlled reactions include nucleic acid hybridization, immunoassays, clinical diagnosis and multi-step combinatorial biopolymer synthesis. Controller interfaces with user via input/output devices preferably including a graphical display. The controller may interface with a power supply and interface, the interface providing selective connection to individual microlocations, polarity reversal, and selective potential or current levels to individual electrodes. A combined system for performing DNA
sample preparation, hybridization, detection and data analysis integrates multiple steps. Charged materials are transported preferably by free field electrophoresis. DNA complexity reduction is preferably achieved by binding DNA to a support, cleaving unbound materials such as by restriction enzymes, and transporting the cleaved fragments. Active, programmable matrix devices include a square matrix pattern with fanned out electrical connections and optional electrical connections beneath specific microlocations resulting in a highly automated DNA diagnostic system.
CA 2199515 1994-09-09 1995-09-06 Automated molecular biological diagnostic system Expired - Fee Related CA2199515C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/304,657 1994-09-09
US08/304,657 US5632957A (en) 1993-11-01 1994-09-09 Molecular biological diagnostic systems including electrodes
PCT/US1995/011333 WO1996007917A1 (en) 1994-09-09 1995-09-06 Automated molecular biological diagnostic system

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CA2199515A1 true CA2199515A1 (en) 1996-03-14
CA2199515C CA2199515C (en) 2003-05-20

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US (2) US5632957A (en)
EP (1) EP0871888B1 (en)
JP (1) JPH10505497A (en)
CN (1) CN1121614C (en)
AT (1) ATE220459T1 (en)
AU (1) AU702773B2 (en)
BR (1) BR9508908A (en)
CA (1) CA2199515C (en)
DE (1) DE69527375T2 (en)
DK (1) DK0871888T3 (en)
ES (1) ES2179114T3 (en)
FI (1) FI970957A (en)
WO (1) WO1996007917A1 (en)

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