CA2198258A1 - Amino acid chelates having improved palatability - Google Patents
Amino acid chelates having improved palatabilityInfo
- Publication number
- CA2198258A1 CA2198258A1 CA002198258A CA2198258A CA2198258A1 CA 2198258 A1 CA2198258 A1 CA 2198258A1 CA 002198258 A CA002198258 A CA 002198258A CA 2198258 A CA2198258 A CA 2198258A CA 2198258 A1 CA2198258 A1 CA 2198258A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- chelate
- ligand
- charge
- polydentate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
- C07F15/06—Cobalt compounds
- C07F15/065—Cobalt compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
- C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic System without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic System
- C07F11/005—Compounds containing elements of Groups 6 or 16 of the Periodic System compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic System without C-Metal linkages
Abstract
A palatable metal amino acid chelate for administration to humans and other warm-blooded animals is disclosed wherein there are sufficient ligands to provide ionic and coordinate covalent bonds equal to the coordination number of the central metal ion while, at the same time, maintaining charge balance in the chelate molecule. There must be at least one ligand of the polydentate type which must be an .alpha.-amino acid with the further proviso that any unidentate or polydentate ligand(s) must be charge balanced organic ligands.
Charge balancing may be accomplished by means of an organic acid and dicarboxylic, hydroxycarboxylic, hydroxydicarboxylic or hydroxytricarboxylic acids in particular, which maintains the chelate molecule as an optimum pH for purposes of stability and palatability.
Charge balancing may be accomplished by means of an organic acid and dicarboxylic, hydroxycarboxylic, hydroxydicarboxylic or hydroxytricarboxylic acids in particular, which maintains the chelate molecule as an optimum pH for purposes of stability and palatability.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/294,632 | 1994-08-23 | ||
US08/294,632 US5516925A (en) | 1994-08-23 | 1994-08-23 | Amino acid chelates having improved palatability |
PCT/US1995/010568 WO1996006101A1 (en) | 1994-08-23 | 1995-08-21 | Amino acid chelates having improved palatability |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2198258A1 true CA2198258A1 (en) | 1996-02-29 |
CA2198258C CA2198258C (en) | 2001-03-27 |
Family
ID=23134256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002198258A Expired - Lifetime CA2198258C (en) | 1994-08-23 | 1995-08-21 | Amino acid chelates having improved palatability |
Country Status (10)
Country | Link |
---|---|
US (1) | US5516925A (en) |
EP (1) | EP0777672A4 (en) |
JP (1) | JP3249129B2 (en) |
AU (1) | AU689312B2 (en) |
BR (1) | BR9508746A (en) |
CA (1) | CA2198258C (en) |
NZ (1) | NZ292002A (en) |
PE (1) | PE62496A1 (en) |
TW (1) | TW360536B (en) |
WO (1) | WO1996006101A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2719289A1 (en) | 2012-10-12 | 2014-04-16 | SC Medisan 2010 SRL | Process for obtainment of amino acids chelates with micro-elements |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK176196B1 (en) | 1997-10-07 | 2007-01-08 | Ejvind Jersie Pedersen | Oral hygiene composition for the treatment of halitosis and the use of a chelate comprising a metal ion moiety and an amino acid moiety as a component of the composition |
US6242009B1 (en) | 1999-04-20 | 2001-06-05 | Kareem I. Batarseh | Microbicidal formulations and methods to control microorganisms |
BR0015182A (en) * | 1999-11-01 | 2002-07-16 | Albion Int | Compositions and methods for calcium fortification of dairy products and oil products |
US6299914B1 (en) | 1999-11-01 | 2001-10-09 | Albion International, Inc. | Compositions and methods for calcium fortification of dairy products and oleaginous foods |
US6294207B1 (en) | 1999-11-01 | 2001-09-25 | Albion International, Inc. | Calcium fortification of oleaginous foods |
KR100421466B1 (en) * | 2000-07-11 | 2004-03-10 | 지성규 | Manufacturing Method of Absorptive Zinc-Oligopeptide in The Human Body |
US6407138B1 (en) | 2000-10-11 | 2002-06-18 | Albion International, Inc. | Composition and method for preparing electrically neutral amino acid chelates free of interfering ions |
US6710079B1 (en) | 2000-10-11 | 2004-03-23 | Albion International, Inc. | Composition and method for preparing amino acid chelates and complexes free of interfering complex ions |
US6630172B2 (en) | 2001-01-22 | 2003-10-07 | Kareem I. Batarseh | Microbicidal composition containing potassium sodium tartrate |
US20030049352A1 (en) * | 2001-05-31 | 2003-03-13 | Haile Mehansho | Fortified drinking water |
US7090878B2 (en) * | 2001-05-31 | 2006-08-15 | The Procter & Gamble Company | Mineral fortified water |
US20030031757A1 (en) * | 2001-08-03 | 2003-02-13 | Kraft Food Holdings, Inc. | Stable and bioavailable iron fortified beverages |
US6716814B2 (en) * | 2001-08-16 | 2004-04-06 | Albion International, Inc. | Enhancing solubility of iron amino acid chelates and iron proteinates |
US6632449B2 (en) | 2001-11-20 | 2003-10-14 | The Procter & Gamble Co. | Compositions and kits comprising a defined boron compound and methods of their preparation |
US20060013892A1 (en) * | 2001-11-28 | 2006-01-19 | Albion International Inc. | Administration of amino acid chelates for reduction in alcohol dependency |
US7910137B2 (en) * | 2001-11-28 | 2011-03-22 | Albion International, Inc. | Metal carnitine chelates |
US20030158171A1 (en) * | 2001-11-28 | 2003-08-21 | Albion International, Inc. | Chelates and complexes for reduction in alcohol dependency |
US6670494B1 (en) | 2001-12-17 | 2003-12-30 | J H Brotech, Inc. | Method for preparation of metal organic acid chelates |
US6992203B2 (en) * | 2002-03-26 | 2006-01-31 | Jh Biotech, Inc. | Metal complexes produced by Maillard Reaction products |
US7994217B2 (en) * | 2002-05-02 | 2011-08-09 | Xanodyne Pharmaceuticals, Inc. | Prenatal multivitamin/multimineral supplement |
US7279187B2 (en) * | 2003-02-14 | 2007-10-09 | The Procter & Gamble Company | Mineral fortification systems |
US7247328B2 (en) * | 2002-05-31 | 2007-07-24 | Zinpro Corporation | Chromium (III) alpha amino acid complexes |
US7129375B2 (en) * | 2002-10-16 | 2006-10-31 | Zinpro Corporation | Metal complexes of α amino dicarboxylic acids |
KR100470763B1 (en) * | 2002-12-05 | 2005-02-21 | 주식회사 엠디바이오알파 | Method For Preparation Of Amino Acid Chelate |
US7022351B2 (en) * | 2003-01-14 | 2006-04-04 | Zinpro Corporation | Composition for supplementing animals with solutions of essential metal amino acid complexes |
WO2004082592A2 (en) * | 2003-03-19 | 2004-09-30 | Ramu Krishnan | Metal amino acid chelates having nutritionally relevant anion radical (s) |
US7175867B2 (en) * | 2003-09-18 | 2007-02-13 | Kraft Foods Holdings, Inc. | Metastable mineral-amino acid preparations for food and beverage fortification |
US20050235718A1 (en) * | 2004-04-21 | 2005-10-27 | Kevin Dickinson | Organic amino acid chelates, methods for making such chelates, and methods for using such chelates |
US7838042B2 (en) * | 2004-04-21 | 2010-11-23 | Albion International, Inc. | Hypoallergenic metal amino acid chelates and metal amino acid chelate-containing compositions |
US20050239763A1 (en) * | 2004-04-21 | 2005-10-27 | Albion International, Inc. | Non-GMO metal amino acid chelates and non-GMO metal amino acid chelate-containing compositions |
WO2006037449A2 (en) * | 2004-10-08 | 2006-04-13 | Unilever N.V. | Iron complex for use in the treatment and/or prevention of nutritional disorders |
US20060134227A1 (en) * | 2004-12-22 | 2006-06-22 | Bortz Jonathan D | Compositions including iron |
US20090035385A1 (en) * | 2004-12-22 | 2009-02-05 | Drugtech Corporation | Compositions including iron |
US20060178834A1 (en) * | 2005-02-08 | 2006-08-10 | Brewer Deanna M | Systems and methods for optimizing crop yield with amino acid chelates and complexes |
JP5167594B2 (en) * | 2005-03-28 | 2013-03-21 | 大正製薬株式会社 | Composition for internal use liquid containing copper compound |
KR101317667B1 (en) * | 2005-12-06 | 2013-10-15 | 가부시끼가이샤 제이씨유 | Palladium complex and catalyst-imparting treatment solution using the same |
US8007846B2 (en) * | 2006-01-18 | 2011-08-30 | Albion International, Inc. | Mixed amino acid/mineral compounds having improved solubility |
US20070270591A1 (en) * | 2006-05-16 | 2007-11-22 | Ashmead H Dewayne | Iron (II) amino acid chelates with reducing agents attached thereto |
US20070269495A1 (en) * | 2006-05-18 | 2007-11-22 | Ashmead H Dewayne | Compositions and methods for enhancing mineral levels in animals with reduced environmental impact |
US20080194679A1 (en) * | 2007-02-14 | 2008-08-14 | Ashmead H Dewayne | Compositions and methods for increasing metabolic activity in animal tissue |
US20080194407A1 (en) * | 2007-02-14 | 2008-08-14 | Ashmead H Dewayne | High nitrogen containing chelate compositions suitable for plant delivery |
US9125844B1 (en) | 2007-09-25 | 2015-09-08 | Argent Development Group, Llc | Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women |
US7964189B1 (en) | 2007-09-25 | 2011-06-21 | Argent Development Group, Llc | Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women |
WO2009089493A2 (en) * | 2008-01-11 | 2009-07-16 | Albion International, Inc. | Nitrate amino acid chelates |
US8535659B1 (en) | 2008-05-27 | 2013-09-17 | Argent Development Group, Llc | Nutritional supplements for pregnant women |
US8535660B1 (en) | 2008-05-27 | 2013-09-17 | Argent Development Group, Llc | Nutritional supplements for pregnant women |
CN102451185A (en) | 2010-10-19 | 2012-05-16 | 长春纳米生技公司 | Metal ion nanocluster composition |
DE102011011924B4 (en) | 2011-02-17 | 2012-12-27 | Isf Gmbh | Process for the preparation of amino acid chelate compounds, amino acid chelate compounds and use of amino acid chelate compounds |
WO2013171164A1 (en) | 2012-05-14 | 2013-11-21 | EJP Pharmaceutical ApS | Compositions and formulations for the treatment of halitosis |
WO2014071176A1 (en) * | 2012-11-02 | 2014-05-08 | Disilvestro Robert | Nutritional supplements including meal replacements and related methods |
US20160024118A1 (en) * | 2013-03-07 | 2016-01-28 | C Lab Pharma International, S.A. | Copper (i) complexes with glycine, pyruvate, and succinate |
US9370202B2 (en) | 2013-03-15 | 2016-06-21 | LG Bionano, LLC | Encapsulated metal ion nanoclusters |
CA2913413C (en) | 2013-06-06 | 2021-11-23 | Amip, Llc | Iron supplement |
US9492421B1 (en) | 2013-11-14 | 2016-11-15 | Argent Development Group, Llc | Nutritional supplements for treatment of iron deficiency anemia |
US9629846B1 (en) | 2013-11-14 | 2017-04-25 | Argent Development Group, Llc | Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women |
WO2016070257A1 (en) * | 2014-11-07 | 2016-05-12 | Npa - Núcleo De Pesquisas Aplicadas Ltda. | Iron amino acid compounds, method for preparing iron amino acid compounds, compositions containing iron amino acid compounds, and uses thereof |
US10653658B2 (en) | 2015-08-11 | 2020-05-19 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
EP3334440B1 (en) | 2015-08-11 | 2021-04-14 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
CN106083627A (en) * | 2016-06-11 | 2016-11-09 | 江西倍得力生物工程有限公司 | A kind of citric acid, aspartic acid are mixed with the method for metal-chelating calcium |
KR102068016B1 (en) * | 2017-07-14 | 2020-01-21 | 씨제이제일제당 주식회사 | Methionine-Metal Chelate and Manufacturing Method thereof |
CN110128307B (en) * | 2019-06-12 | 2021-06-29 | 天宝动物营养科技股份有限公司 | Preparation method of stable ferrous amino acid complex |
CN112137995A (en) | 2019-06-28 | 2020-12-29 | 默克专利股份有限公司 | Methods and mixtures for increasing the cellular availability of calcium in skin cells |
CN112409202A (en) * | 2020-12-23 | 2021-02-26 | 河南九天生物科技有限公司 | Amino acid Fe (III) chelate for treating and preventing iron deficiency anemia and process thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4216143A (en) * | 1977-10-20 | 1980-08-05 | Ashmead H H | Soluble non-ferrous metal proteinates |
US4216144A (en) * | 1977-10-20 | 1980-08-05 | Ashmead H H | Soluble iron proteinates |
US4599152A (en) * | 1985-05-24 | 1986-07-08 | Albion Laboratories | Pure amino acid chelates |
US4830716B1 (en) * | 1986-07-03 | 1999-12-07 | Albion Int | Preparation of pharmaceutical grade amino acid chelates |
-
1994
- 1994-08-23 US US08/294,632 patent/US5516925A/en not_active Expired - Lifetime
-
1995
- 1995-08-21 EP EP95930220A patent/EP0777672A4/en not_active Withdrawn
- 1995-08-21 JP JP50822696A patent/JP3249129B2/en not_active Expired - Fee Related
- 1995-08-21 BR BR9508746A patent/BR9508746A/en not_active IP Right Cessation
- 1995-08-21 NZ NZ292002A patent/NZ292002A/en unknown
- 1995-08-21 AU AU33681/95A patent/AU689312B2/en not_active Ceased
- 1995-08-21 WO PCT/US1995/010568 patent/WO1996006101A1/en not_active Application Discontinuation
- 1995-08-21 CA CA002198258A patent/CA2198258C/en not_active Expired - Lifetime
- 1995-08-23 PE PE1995277112A patent/PE62496A1/en not_active Application Discontinuation
- 1995-08-25 TW TW084108885A patent/TW360536B/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2719289A1 (en) | 2012-10-12 | 2014-04-16 | SC Medisan 2010 SRL | Process for obtainment of amino acids chelates with micro-elements |
Also Published As
Publication number | Publication date |
---|---|
TW360536B (en) | 1999-06-11 |
AU3368195A (en) | 1996-03-14 |
EP0777672A1 (en) | 1997-06-11 |
WO1996006101A1 (en) | 1996-02-29 |
BR9508746A (en) | 1997-12-30 |
US5516925A (en) | 1996-05-14 |
NZ292002A (en) | 1997-05-26 |
JPH10504822A (en) | 1998-05-12 |
PE62496A1 (en) | 1996-12-31 |
EP0777672A4 (en) | 2000-04-05 |
CA2198258C (en) | 2001-03-27 |
JP3249129B2 (en) | 2002-01-21 |
AU689312B2 (en) | 1998-03-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20150821 |