CA2196165A1 - Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods - Google Patents
Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methodsInfo
- Publication number
- CA2196165A1 CA2196165A1 CA002196165A CA2196165A CA2196165A1 CA 2196165 A1 CA2196165 A1 CA 2196165A1 CA 002196165 A CA002196165 A CA 002196165A CA 2196165 A CA2196165 A CA 2196165A CA 2196165 A1 CA2196165 A1 CA 2196165A1
- Authority
- CA
- Canada
- Prior art keywords
- methods
- calcification
- glutaraldehyde
- bioprosthetic
- mitigate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/915—Method or apparatus for preparing biological material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutaraldehyde.
Alternatively, methods other than heating (e. g., chemical or mechanical means) , for effecting polymerization of the glutaraldehyde may also be utilized. Alternatively, the tissue may be heat treated prior to fixing thereof.
Alternatively, methods other than glutaraldehyde may also be used far fixing the tissue. The biological tissue may be so treated at any time prior to implantation thereof in a mammalian body.
Alternatively, methods other than heating (e. g., chemical or mechanical means) , for effecting polymerization of the glutaraldehyde may also be utilized. Alternatively, the tissue may be heat treated prior to fixing thereof.
Alternatively, methods other than glutaraldehyde may also be used far fixing the tissue. The biological tissue may be so treated at any time prior to implantation thereof in a mammalian body.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28235894A | 1994-07-29 | 1994-07-29 | |
US08/282,358 | 1994-07-29 | ||
PCT/US1995/010001 WO1996004028A1 (en) | 1994-07-29 | 1995-07-25 | Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2196165A1 true CA2196165A1 (en) | 1996-02-15 |
CA2196165C CA2196165C (en) | 2004-06-08 |
Family
ID=23081148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002196165A Expired - Lifetime CA2196165C (en) | 1994-07-29 | 1995-07-25 | Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods |
Country Status (6)
Country | Link |
---|---|
US (2) | US6561970B1 (en) |
EP (1) | EP0804255B1 (en) |
JP (1) | JP3797673B2 (en) |
CA (1) | CA2196165C (en) |
DE (1) | DE69523074T2 (en) |
WO (1) | WO1996004028A1 (en) |
Families Citing this family (84)
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DE69523074T2 (en) | 1994-07-29 | 2002-06-06 | Edwards Lifesciences Corp | METHOD FOR TREATING IMPLANTABLE BIOLOGICAL TISSUES TO REDUCE CALCIFICATION |
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JP4271262B2 (en) * | 1997-02-10 | 2009-06-03 | バイオメディカル デザイン インコーポレイテッド | Sterilization method |
US5891196A (en) | 1997-04-16 | 1999-04-06 | Baxter International Inc. | Method for actively binding heparin to crosslinked biological tissues |
US6008292A (en) * | 1997-12-02 | 1999-12-28 | Baxter International Inc. | Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials |
BE1012763A3 (en) | 1999-06-25 | 2001-03-06 | Wiele Michel Van De Nv | Yarn pool selection system grijperaxminsterweefmachines. |
-
1995
- 1995-07-25 DE DE69523074T patent/DE69523074T2/en not_active Expired - Lifetime
- 1995-07-25 JP JP50681296A patent/JP3797673B2/en not_active Expired - Lifetime
- 1995-07-25 EP EP95931511A patent/EP0804255B1/en not_active Expired - Lifetime
- 1995-07-25 CA CA002196165A patent/CA2196165C/en not_active Expired - Lifetime
- 1995-07-25 WO PCT/US1995/010001 patent/WO1996004028A1/en active IP Right Grant
-
1996
- 1996-12-12 US US08/764,821 patent/US6561970B1/en not_active Expired - Lifetime
-
2003
- 2003-02-05 US US10/359,479 patent/US7029434B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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EP0804255B1 (en) | 2001-10-04 |
US6561970B1 (en) | 2003-05-13 |
JP3797673B2 (en) | 2006-07-19 |
EP0804255A1 (en) | 1997-11-05 |
US7029434B2 (en) | 2006-04-18 |
CA2196165C (en) | 2004-06-08 |
JPH10507102A (en) | 1998-07-14 |
WO1996004028A1 (en) | 1996-02-15 |
US20040030405A1 (en) | 2004-02-12 |
DE69523074T2 (en) | 2002-06-06 |
DE69523074D1 (en) | 2001-11-08 |
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