CA2196165A1 - Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods - Google Patents

Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods

Info

Publication number
CA2196165A1
CA2196165A1 CA002196165A CA2196165A CA2196165A1 CA 2196165 A1 CA2196165 A1 CA 2196165A1 CA 002196165 A CA002196165 A CA 002196165A CA 2196165 A CA2196165 A CA 2196165A CA 2196165 A1 CA2196165 A1 CA 2196165A1
Authority
CA
Canada
Prior art keywords
methods
calcification
glutaraldehyde
bioprosthetic
mitigate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002196165A
Other languages
French (fr)
Other versions
CA2196165C (en
Inventor
Sophie Carpentier
Alain Carpentier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Edwards Lifesciences Corp
Original Assignee
Sophie Carpentier
Alain Carpentier
Baxter International Inc.
Edwards Lifesciences Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sophie Carpentier, Alain Carpentier, Baxter International Inc., Edwards Lifesciences Corporation filed Critical Sophie Carpentier
Publication of CA2196165A1 publication Critical patent/CA2196165A1/en
Application granted granted Critical
Publication of CA2196165C publication Critical patent/CA2196165C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material

Abstract

A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutaraldehyde.
Alternatively, methods other than heating (e. g., chemical or mechanical means) , for effecting polymerization of the glutaraldehyde may also be utilized. Alternatively, the tissue may be heat treated prior to fixing thereof.
Alternatively, methods other than glutaraldehyde may also be used far fixing the tissue. The biological tissue may be so treated at any time prior to implantation thereof in a mammalian body.
CA002196165A 1994-07-29 1995-07-25 Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods Expired - Lifetime CA2196165C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28235894A 1994-07-29 1994-07-29
US08/282,358 1994-07-29
PCT/US1995/010001 WO1996004028A1 (en) 1994-07-29 1995-07-25 Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods

Publications (2)

Publication Number Publication Date
CA2196165A1 true CA2196165A1 (en) 1996-02-15
CA2196165C CA2196165C (en) 2004-06-08

Family

ID=23081148

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002196165A Expired - Lifetime CA2196165C (en) 1994-07-29 1995-07-25 Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods

Country Status (6)

Country Link
US (2) US6561970B1 (en)
EP (1) EP0804255B1 (en)
JP (1) JP3797673B2 (en)
CA (1) CA2196165C (en)
DE (1) DE69523074T2 (en)
WO (1) WO1996004028A1 (en)

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Also Published As

Publication number Publication date
US6561970B1 (en) 2003-05-13
WO1996004028A1 (en) 1996-02-15
DE69523074D1 (en) 2001-11-08
US7029434B2 (en) 2006-04-18
US20040030405A1 (en) 2004-02-12
JP3797673B2 (en) 2006-07-19
CA2196165C (en) 2004-06-08
EP0804255B1 (en) 2001-10-04
JPH10507102A (en) 1998-07-14
DE69523074T2 (en) 2002-06-06
EP0804255A1 (en) 1997-11-05

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