CA2192005A1 - Rolling door made from interlocking thermoplastic panels - Google Patents

Rolling door made from interlocking thermoplastic panels

Info

Publication number
CA2192005A1
CA2192005A1 CA002192005A CA2192005A CA2192005A1 CA 2192005 A1 CA2192005 A1 CA 2192005A1 CA 002192005 A CA002192005 A CA 002192005A CA 2192005 A CA2192005 A CA 2192005A CA 2192005 A1 CA2192005 A1 CA 2192005A1
Authority
CA
Canada
Prior art keywords
wall
panels
main body
neck
head
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002192005A
Other languages
French (fr)
Other versions
CA2192005C (en
Inventor
Andrew Rekret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proplas Ltd
Original Assignee
Proplas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26948575&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2192005(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Proplas Ltd filed Critical Proplas Ltd
Publication of CA2192005A1 publication Critical patent/CA2192005A1/en
Application granted granted Critical
Publication of CA2192005C publication Critical patent/CA2192005C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B01L3/0248—Prongs, quill pen type dispenser
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezo-electric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00475—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/115831—Condition or time responsive
    • Y10T436/116664—Condition or time responsive with automated titrator

Abstract

A hinged panel door comprises a plurality of thermoplastic panels each having a main body with an outside wall, an inside wall, an open ended female receptacle formed centrally in one end and a male receptacle protruding centrally from the other end of the main body. The male connector has a rounded head and a neck joining the head to a shoulder on the main body of the panel. Both the head and the shoulder are wider than the neck. The female receptacle is formed by a rounded wall circumscribing the major part of a circle and interrupted by a mouth having a width slightly greater than that of the neck of the male connector. The inner wall of the panel is shorter than the outer wall which provides a one way hinged connection between the receptacle of one of the panels and the connector of another one of the panels.
CA002192005A 1994-06-17 1996-12-04 Rolling door made from interlocking thermoplastic panels Expired - Fee Related CA2192005C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26138894A 1994-06-17 1994-06-17
US08/477,809 US5807522A (en) 1994-06-17 1995-06-07 Methods for fabricating microarrays of biological samples
PCT/US1995/007659 WO1995035505A1 (en) 1994-06-17 1995-06-16 Method and apparatus for fabricating microarrays of biological samples

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA 2210018 Division CA2210018A1 (en) 1996-12-04 1996-12-04 Rolling door made from interlocking thermoplastic panels

Publications (2)

Publication Number Publication Date
CA2192005A1 true CA2192005A1 (en) 1998-06-04
CA2192005C CA2192005C (en) 2005-10-25

Family

ID=26948575

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002192095A Expired - Fee Related CA2192095C (en) 1994-06-17 1995-06-16 Method and apparatus for fabricating microarrays of biological samples
CA002192005A Expired - Fee Related CA2192005C (en) 1994-06-17 1996-12-04 Rolling door made from interlocking thermoplastic panels

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002192095A Expired - Fee Related CA2192095C (en) 1994-06-17 1995-06-16 Method and apparatus for fabricating microarrays of biological samples

Country Status (11)

Country Link
US (2) US5807522A (en)
EP (2) EP0804731B2 (en)
JP (2) JP3272365B2 (en)
AT (1) ATE180570T1 (en)
AU (1) AU709276B2 (en)
CA (2) CA2192095C (en)
DE (1) DE69509925T3 (en)
DK (1) DK0804731T4 (en)
ES (1) ES2134481T5 (en)
GR (1) GR3030430T3 (en)
WO (1) WO1995035505A1 (en)

Families Citing this family (1377)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6379895B1 (en) 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
EP0834576B1 (en) 1990-12-06 2002-01-16 Affymetrix, Inc. (a Delaware Corporation) Detection of nucleic acid sequences
CA2124087C (en) * 1991-11-22 2002-10-01 James L. Winkler Combinatorial strategies for polymer synthesis
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
DE4344726C2 (en) * 1993-12-27 1997-09-25 Deutsches Krebsforsch Method for the detection of unbalanced genetic material of a species or for the detection of gene expression in cells of a species
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US7615368B1 (en) 1994-06-17 2009-11-10 The Board Of Trustees Of The Leland Stanford Junior University Microarrays of polypeptides
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
GB9418981D0 (en) * 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6121048A (en) * 1994-10-18 2000-09-19 Zaffaroni; Alejandro C. Method of conducting a plurality of reactions
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US8236493B2 (en) 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
SE9404166D0 (en) * 1994-11-30 1994-11-30 Pharmacia Biotech Ab Multifunctional surfaces
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US6428955B1 (en) 1995-03-17 2002-08-06 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US7803529B1 (en) 1995-04-11 2010-09-28 Sequenom, Inc. Solid phase sequencing of biopolymers
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
US7468243B2 (en) 2001-03-12 2008-12-23 Affymetrix, Inc. 2-aminopyrimidin-4-one nucleic acid labeling compounds
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
US7423143B2 (en) 1996-01-23 2008-09-09 Affymetrix. Inc. Nucleic acid labeling compounds
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc Nucleic acid analysis techniques
US6864059B2 (en) 1996-01-23 2005-03-08 Affymetrix, Inc. Biotin containing C-glycoside nucleic acid labeling compounds
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
US7291463B2 (en) 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
US5837196A (en) * 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
EP0886681A1 (en) * 1996-03-04 1998-12-30 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US6361937B1 (en) 1996-03-19 2002-03-26 Affymetrix, Incorporated Computer-aided nucleic acid sequencing
US7244622B2 (en) * 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US5958342A (en) * 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
DE19628928A1 (en) 1996-07-18 1998-01-22 Basf Ag Solid supports for analytical measurement processes, a process for their production and their use
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6329140B1 (en) * 1996-09-19 2001-12-11 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
US5777324A (en) * 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US6391550B1 (en) * 1996-09-19 2002-05-21 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
US6124092A (en) 1996-10-04 2000-09-26 The Perkin-Elmer Corporation Multiplex polynucleotide capture methods and compositions
GB9622665D0 (en) * 1996-10-31 1997-01-08 Zeneca Ltd Methods
AU761161B2 (en) * 1996-11-06 2003-05-29 Sequenom, Inc. High density immobilization of nucleic acids
US7285422B1 (en) 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
DK0937096T3 (en) 1996-11-06 2004-06-14 Sequenom Inc Method of mass spectrometry analysis
AU745624B2 (en) * 1996-11-06 2002-03-28 Sequenom, Inc. High density immobilization of nucleic acids
US6024925A (en) * 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
US6503452B1 (en) * 1996-11-29 2003-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biosensor arrays and methods
US6699719B2 (en) * 1996-11-29 2004-03-02 Proteomic Systems, Inc. Biosensor arrays and methods
US6054325A (en) * 1996-12-02 2000-04-25 Glaxo Wellcom Inc. Method and apparatus for transferring and combining distinct chemical compositions with reagents
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
DE69735445T2 (en) 1996-12-10 2006-08-10 Sequenom, Inc., San Diego NON-VOLATILE, NON-VOLATILE MOLECULES FOR MASS MARKING
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
EP1249705A3 (en) 1996-12-31 2003-11-05 Genometrix Genomics Incorporated Multiplexed molecular analysis apparatus and its fabrication method
US6303301B1 (en) * 1997-01-13 2001-10-16 Affymetrix, Inc. Expression monitoring for gene function identification
US6309824B1 (en) * 1997-01-16 2001-10-30 Hyseq, Inc. Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes
DE19707204A1 (en) * 1997-02-24 1998-08-27 Boehringer Mannheim Gmbh System for the production of multiple diagnostic test elements
US6553317B1 (en) * 1997-03-05 2003-04-22 Incyte Pharmaceuticals, Inc. Relational database and system for storing information relating to biomolecular sequences and reagents
JP2001518086A (en) * 1997-03-20 2001-10-09 ユニバーシティ オブ ワシントン Solvents, solvent microdroplets, and methods of use for biopolymer synthesis
US6028189A (en) * 1997-03-20 2000-02-22 University Of Washington Solvent for oligonucleotide synthesis and methods of use
US6419883B1 (en) 1998-01-16 2002-07-16 University Of Washington Chemical synthesis using solvent microdroplets
EP0985142A4 (en) 1997-05-23 2006-09-13 Lynx Therapeutics Inc System and apparaus for sequential processing of analytes
JP4303793B2 (en) * 1997-06-02 2009-07-29 オーロラ バイオサイエンシズ コーポレーション Low background multiwell plate for fluorescence measurements of biological and biochemical samples
JP3120453B2 (en) * 1997-06-19 2000-12-25 トヨタ自動車株式会社 Method for holding and reacting microdroplets
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
AU8177398A (en) * 1997-06-30 1999-01-19 Government of the United States of America, as represented by The Secretary of the Department of Health and Human Services and His Successors, The Spectral cloning-a new technical approach to the cloning and characterization ofevery chromosomal aberration in cancer samples
EP0996500A1 (en) 1997-07-22 2000-05-03 Rapigene, Inc. Apparatus and methods for arraying solution onto a solid support
NZ501774A (en) 1997-07-22 2002-02-01 Qiagen Genomics Inc Computer method and system for correlating known characteristics of biomolecules to molecular tags with unique molecular weights that are associated with the biomolecule
CN1265156A (en) 1997-07-22 2000-08-30 拉普吉恩公司 Amplification and other enzymatic reactions preformed on nucleic acid arrays
ATE443866T1 (en) * 1997-08-01 2009-10-15 Canon Kk REACTION SITE ARRAY, METHOD FOR PRODUCING IT, REACTION METHOD USING IT AND QUANTITATIVE DETERMINATION METHOD FOR A SUBSTANCE IN A SAMPLE SOLUTION USING IT
JP4313861B2 (en) * 1997-08-01 2009-08-12 キヤノン株式会社 Manufacturing method of probe array
US6432639B1 (en) 1997-09-10 2002-08-13 Dna Sciences Laboratories, Inc. Isolated CYP3A4 nucleic acid molecules and detection methods
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6013486A (en) * 1997-09-17 2000-01-11 Yale University Method for selection of insertion mutants
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
DE19742246A1 (en) * 1997-09-25 1999-04-01 Basf Ag Analytical measurement method and its use
US6762019B2 (en) * 1997-09-30 2004-07-13 Surmodics, Inc. Epoxide polymer surfaces
US6465178B2 (en) * 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
US7157234B2 (en) 1997-10-24 2007-01-02 Beckman Coulter, Inc. Detection of very low quantities of analyte bound to a solid phase
US7351578B2 (en) 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
ATE215401T1 (en) * 1997-10-31 2002-04-15 Pe Corp Ny METHOD AND DEVICE FOR PRODUCING SAMPLE MATRIXES
US7321023B2 (en) * 1997-11-07 2008-01-22 Incyte Corporation SP16 protein
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US6177558B1 (en) 1997-11-13 2001-01-23 Protogene Laboratories, Inc. Method and composition for chemical synthesis using high boiling point organic solvents to control evaporation
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
US6268131B1 (en) 1997-12-15 2001-07-31 Sequenom, Inc. Mass spectrometric methods for sequencing nucleic acids
US5957167A (en) * 1997-12-18 1999-09-28 Pharmacopeia, Inc. Article for dispensing small volumes of liquid
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US20030096232A1 (en) * 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6265163B1 (en) 1998-01-09 2001-07-24 Lynx Therapeutics, Inc. Solid phase selection of differentially expressed genes
US7470547B2 (en) * 2003-07-31 2008-12-30 Biodot, Inc. Methods and systems for dispensing sub-microfluidic drops
US20020159919A1 (en) * 1998-01-09 2002-10-31 Carl Churchill Method and apparatus for high-speed microfluidic dispensing using text file control
US6063339A (en) * 1998-01-09 2000-05-16 Cartesian Technologies, Inc. Method and apparatus for high-speed dot array dispensing
EP1714699B1 (en) * 1998-01-12 2010-08-18 Massachusetts Institute of Technology System for analyzing a plurality of samples
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6428752B1 (en) 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
US6269846B1 (en) 1998-01-13 2001-08-07 Genetic Microsystems, Inc. Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays
US6407858B1 (en) 1998-05-14 2002-06-18 Genetic Microsystems, Inc Focusing of microscopes and reading of microarrays
US6722395B2 (en) * 1998-01-13 2004-04-20 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
CA2319148A1 (en) * 1998-01-26 1999-07-29 Bruce L. Roberts Methods for identifying therapeutic targets
US6297010B1 (en) 1998-01-30 2001-10-02 Genzyme Corporation Method for detecting and identifying mutations
WO1999040434A1 (en) 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
US6537505B1 (en) 1998-02-20 2003-03-25 Bio Dot, Inc. Reagent dispensing valve
GB9803684D0 (en) * 1998-02-24 1998-04-15 Genevac Ltd Method and apparatus for controlling temperature during evaporation of samples
US20020090639A1 (en) * 1998-02-26 2002-07-11 Mcginnis Ralph Evan Two dimensional linkage study methods and related inventions
US6610526B2 (en) * 1998-03-13 2003-08-26 Inctye Corporation Human E1-like protein
FR2776389B1 (en) * 1998-03-20 2000-06-16 Fondation Jean Dausset Ceph AUTOMATIC DEVICE FOR PRODUCING SAMPLES FOR THE IMPLEMENTATION OF CHEMICAL OR BIOLOGICAL REACTIONS IN A LIQUID MEDIUM
US7095032B2 (en) * 1998-03-20 2006-08-22 Montagu Jean I Focusing of microscopes and reading of microarrays
US6218114B1 (en) * 1998-03-27 2001-04-17 Academia Sinica Methods for detecting differentially expressed genes
US6077673A (en) * 1998-03-31 2000-06-20 Clontech Laboratories, Inc. Mouse arrays and kits comprising the same
EP0955084B1 (en) 1998-04-27 2006-07-26 Corning Incorporated Method of depositing an array of biological samples using a redrawn capillary reservoir
US6884626B1 (en) 1998-04-27 2005-04-26 Corning Incorporated Redrawn capillary imaging reservoir
US6350618B1 (en) 1998-04-27 2002-02-26 Corning Incorporated Redrawn capillary imaging reservoir
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
DE19823660C1 (en) * 1998-05-20 1999-10-07 Nanomont Ges Fuer Nanotechnolo Process and assembly to apply and fix biochemically-active micro- and nano- micro-spheres on a substrate, especially useful in biochemical analysis such as DNA, viral and genetic testing
US6268210B1 (en) * 1998-05-27 2001-07-31 Hyseq, Inc. Sandwich arrays of biological compounds
AU754952B2 (en) 1998-06-24 2002-11-28 Illumina, Inc. Decoding of array sensors with microspheres
AU4834999A (en) 1998-06-26 2000-01-17 Incyte Pharmaceuticals, Inc. Human signal peptide-containing proteins
US6762061B1 (en) 1998-07-03 2004-07-13 Corning Incorporated Redrawn capillary imaging reservoir
AU4861099A (en) * 1998-07-07 2000-01-24 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
US6551557B1 (en) 1998-07-07 2003-04-22 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6897073B2 (en) 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
AU2003262452B2 (en) * 1998-07-14 2007-02-08 Zyomyx, Inc. Arrays of proteins and methods of use thereof I
US6291190B1 (en) 1998-08-25 2001-09-18 The Board Of Trustees Of The Leland Stanford Junior University Molecular differences between species of the M. tuberculosis complex
US6929912B2 (en) 1998-08-31 2005-08-16 Genaissance Pharmaceuticals, Inc. Methods for evaluating the ability to metabolize pharmaceuticals
US6461812B2 (en) 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
US6309891B1 (en) * 1998-09-09 2001-10-30 Incyte Genomics, Inc. Capillary printing systems
US20020012913A1 (en) * 1998-09-15 2002-01-31 Kevin L. Gunderson Nucleic acid analysis using complete n-mer arrays
US6475440B1 (en) 1998-09-16 2002-11-05 Clontech Laboratories, Inc. Applicator for use in deposition of fluid samples onto a substrate surface
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
US6689323B2 (en) 1998-10-30 2004-02-10 Agilent Technologies Method and apparatus for liquid transfer
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US7014815B1 (en) 1998-10-30 2006-03-21 Burstein Technologies, Inc. Trackable optical discs with concurrently readable nonoperational features
CN1331700A (en) 1998-11-16 2002-01-16 基因纬生物技术公司 Generation of antibodies using polynucleotide vaccination in avian species
US6309828B1 (en) 1998-11-18 2001-10-30 Agilent Technologies, Inc. Method and apparatus for fabricating replicate arrays of nucleic acid molecules
US6184347B1 (en) * 1998-11-19 2001-02-06 Agilent Technologies Inc. Minimization of blooming in high-density arrays by using reactive wash reagents
US6441152B1 (en) * 1998-12-08 2002-08-27 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
US6881570B1 (en) * 1998-12-15 2005-04-19 Fuji Photo Film Co., Ltd. Test piece and quantitative method and apparatus for an organism-oriented substance
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US7612020B2 (en) 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US6351712B1 (en) * 1998-12-28 2002-02-26 Rosetta Inpharmatics, Inc. Statistical combining of cell expression profiles
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
ATE277065T1 (en) 1999-01-05 2004-10-15 Bio Merieux FUNCTIONALIZED COMPOUND, OPTIONALLY LABELED POLYNUCLEOTIDES AND METHOD FOR DETECTING A TARGET NUCLEIC ACID
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
CA2358566A1 (en) 1999-01-08 2000-07-13 Charles S. Vann Fiber array for contacting chemical species and methods for using and making same
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
US6720139B1 (en) 1999-01-27 2004-04-13 Elitra Pharmaceuticals, Inc. Genes identified as required for proliferation in Escherichia coli
US9534254B1 (en) 1999-02-02 2017-01-03 Abbott Molecular Inc. Patient stratification for cancer therapy based on genomic DNA microarray analysis
US6429302B1 (en) 1999-02-02 2002-08-06 Chiron Corporation Polynucleotides related to pancreatic disease
US6251601B1 (en) * 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
US6232129B1 (en) 1999-02-03 2001-05-15 Peter Wiktor Piezoelectric pipetting device
EP1026259B1 (en) * 1999-02-08 2002-11-27 Fuji Photo Film Co., Ltd. Process for preparing a dna chip
US6432719B1 (en) 1999-02-16 2002-08-13 Pe Corporation (Ny) Matrix storage and dispensing system
US7101510B2 (en) 1999-02-16 2006-09-05 Applera Corporation Matrix storage and dispensing system
US7659386B2 (en) 2000-08-03 2010-02-09 Ceres, Inc. Nucleic acid sequences encoding transcription factor proteins
US8710201B2 (en) 1999-12-08 2014-04-29 Ceres, Inc. Nucleic acid sequences encoding strictosidine synthase proteins
US7365183B2 (en) 2001-01-03 2008-04-29 Ceres, Inc. Sequence-determined DNA fragments encoding SRF-type transcription factor proteins
US8710204B2 (en) 1999-02-25 2014-04-29 Ceres, Inc. Nucleic acid sequences encoding secE/sec61-gamma subunits of protein translocation complexes
US8299231B2 (en) 1999-03-09 2012-10-30 Ceres, Inc. Nucleic acid sequences encoding AN1-like zinc finger proteins
EP1586645A3 (en) 1999-02-25 2006-02-22 Ceres Incorporated Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US6627157B1 (en) 1999-03-04 2003-09-30 Ut-Battelle, Llc Dual manifold system and method for fluid transfer
US9000140B2 (en) 1999-03-05 2015-04-07 Ceres, Inc. Sequence-determined DNA fragments encoding AN1-like zinc finger proteins
FR2790766B1 (en) * 1999-03-08 2002-12-20 Commissariat Energie Atomique METHOD FOR PRODUCING A CHEMICAL OR BIOLOGICAL MOLECULE SEQUENCE MATRIX FOR A CHEMICAL OR BIOLOGICAL ANALYSIS DEVICE
US6296702B1 (en) * 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
CA2367912A1 (en) * 1999-03-19 2000-09-28 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
AU3915400A (en) * 1999-03-22 2000-10-09 Novo Nordisk A/S Methods for monitoring multiple gene expression
AU4025300A (en) * 1999-03-24 2000-10-09 Packard Bioscience Company Continuous porous matrix arrays
US6347259B1 (en) 1999-04-01 2002-02-12 Virtek Vision International Inc. High precision positioning device and method of operating same
US6235479B1 (en) 1999-04-13 2001-05-22 Bio Merieux, Inc. Methods and devices for performing analysis of a nucleic acid sample
EP1171589A1 (en) * 1999-04-15 2002-01-16 Cambridge University Technical Services Limited A novel family of beta sub-unit proteins from a voltage-gated sodium channel, nucleic acids encoding them and therapeutic or diagnostic uses thereof
WO2000063701A2 (en) * 1999-04-15 2000-10-26 The Board Of Trustees Of The Leland Stanford Junior University Microarrays of polypeptides
US6245297B1 (en) 1999-04-16 2001-06-12 Pe Corporation (Ny) Apparatus and method for transferring small volumes of substances
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030215821A1 (en) * 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
ATE504937T1 (en) * 1999-04-27 2011-04-15 Bio Rad Laboratories SAMPLE HOLDER FOR A GAS PHASE ION SPECTROMETER
JP2001021558A (en) * 1999-04-30 2001-01-26 Agilent Technol Inc Preparation of polynucleotide array
US20040203047A1 (en) * 1999-04-30 2004-10-14 Caren Michael P. Polynucleotide array fabrication
US7276336B1 (en) 1999-07-22 2007-10-02 Agilent Technologies, Inc. Methods of fabricating an addressable array of biopolymer probes
US6395559B1 (en) * 1999-05-04 2002-05-28 Orchid Biosciences, Inc. Multiple fluid sample processor with single well addressability
US6824987B1 (en) 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
US20020182749A1 (en) * 1999-05-11 2002-12-05 Aclara Biosciences, Inc. Sample evaporative control
US7932213B2 (en) * 1999-05-11 2011-04-26 President And Fellows Of Harvard College Small molecule printing
US6852493B2 (en) * 1999-05-14 2005-02-08 Iris Biotechnologies, Inc. Magnetic field enhanced hybridization of target molecules to immobilized probes
JP3957118B2 (en) * 1999-05-18 2007-08-15 富士フイルム株式会社 Test piece and image information reading device from the test piece
US6365410B1 (en) * 1999-05-19 2002-04-02 Genencor International, Inc. Directed evolution of microorganisms
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
JP4598960B2 (en) * 1999-05-19 2010-12-15 エッペンドルフ アレイ テクノロジーズ エスアー （エーアーテー） On-chip identification and / or quantification method of target compounds obtained from biological samples
US20030073250A1 (en) * 1999-05-21 2003-04-17 Eric Henderson Method and apparatus for solid state molecular analysis
US20030186311A1 (en) * 1999-05-21 2003-10-02 Bioforce Nanosciences, Inc. Parallel analysis of molecular interactions
EP1185711A4 (en) * 1999-05-21 2002-09-18 Invitrogen Corp Compositions and methods for labeling of nucleic acid molecules
US6573369B2 (en) * 1999-05-21 2003-06-03 Bioforce Nanosciences, Inc. Method and apparatus for solid state molecular analysis
US20020042081A1 (en) * 2000-10-10 2002-04-11 Eric Henderson Evaluating binding affinities by force stratification and force panning
US6225109B1 (en) * 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
EP1183103B1 (en) * 1999-05-27 2003-02-12 PE Corporation (NY) Apparatus and method for the precise location of reaction plates
WO2000075377A2 (en) * 1999-06-03 2000-12-14 Jacques Schrenzel Non-cognate hybridization system (nchs)
US6716579B1 (en) 1999-06-11 2004-04-06 Narayan Baidya Gene specific arrays, preparation and use
WO2000079006A1 (en) * 1999-06-17 2000-12-28 Fred Hutchinson Cancer Research Center Oligonucleotide arrays for high resolution hla typing
US6296673B1 (en) * 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US7420049B2 (en) 1999-06-18 2008-09-02 Ceres, Inc. Sequence-determined DNA fragments encoding AP2 domain proteins
US7399850B2 (en) 1999-06-18 2008-07-15 Ceres, Inc. Sequence-determined DNA fragments encoding AP2 domain proteins
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US7485715B2 (en) 1999-06-18 2009-02-03 Ceres, Inc. Sequence-determined DNA encoding AP2 domain polypeptides
US6656682B1 (en) 1999-06-21 2003-12-02 Nisshinbo Industries, Inc. Nucleic acid-immobilized substrate
US6399394B1 (en) 1999-06-30 2002-06-04 Agilent Technologies, Inc. Testing multiple fluid samples with multiple biopolymer arrays
US6692914B1 (en) 1999-07-02 2004-02-17 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
GB9916406D0 (en) * 1999-07-13 1999-09-15 Biorobotics Ltd Liquid transfer pin
US6346423B1 (en) 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
US6306599B1 (en) 1999-07-16 2001-10-23 Agilent Technologies Inc. Biopolymer arrays and their fabrication
US7371516B1 (en) * 1999-07-16 2008-05-13 Rosetta Inpharmatics Llc Methods for determining the specificity and sensitivity of oligonucleo tides for hybridization
US7209836B1 (en) * 1999-07-16 2007-04-24 Perkinelmer Las, Inc. Method and system for automatically creating crosstalk-corrected data of a microarray
GB2348002B (en) * 1999-07-20 2001-02-07 Genpak Ltd Microarrayer
DE19933838A1 (en) * 1999-07-20 2001-02-01 Max Planck Gesellschaft Needle and liquid transfer method and method of making the needle
US7479555B2 (en) 1999-07-21 2009-01-20 Ceres, Inc. Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity
US20090011945A1 (en) * 1999-07-28 2009-01-08 Bright Frank V Method For Making Microsensor Arrays For Detecting Analytes
US20030170908A1 (en) * 2000-07-28 2003-09-11 Bright Frank V. Method for making microsensor arrays for detecting analytes
AU6611900A (en) * 1999-07-30 2001-03-13 Agy Therapeutics, Inc. Techniques for facilitating identification of candidate genes
KR100320752B1 (en) * 1999-08-06 2002-01-17 박한오 automated microarray of samples
WO2001010903A2 (en) * 1999-08-09 2001-02-15 Incyte Genomics, Inc. Proteases and protease inhibitors
DE60028665T2 (en) * 1999-08-09 2007-06-06 Thk Co., Ltd. Device for producing microarrays
US6498032B1 (en) * 1999-08-11 2002-12-24 Corning Incorporated Use of ceramic labels for identifying biomolecule immobilizing subtrates
CA2391758C (en) * 1999-08-13 2010-02-16 Cartesian Technologies, Inc. Apparatus for liquid sample handling
ATE414171T1 (en) * 1999-08-27 2008-11-15 Matrix Technologies Corp METHOD FOR IMMOBILIZING OLIGONUCLEOTIDES ON SOLID SUPPORT MATERIAL
US6528319B1 (en) 1999-09-02 2003-03-04 Amersham Biosciences Corp Method for anchoring oligonucleotides to a substrate
EP1212461A4 (en) * 1999-09-02 2006-10-18 Corning Inc Porous substrates for dna arrays
US6994972B2 (en) * 1999-09-02 2006-02-07 Corning Incorporated Porous substrates for DNA arrays
US6750023B2 (en) * 1999-09-02 2004-06-15 Corning Incorporated Porous inorganic substrate for high-density arrays
CA2384650A1 (en) * 1999-09-10 2001-03-15 Incyte Genomics, Inc. Apoptosis proteins
FR2798673B1 (en) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa METHODS AND COMPOSITIONS FOR DETECTION OF PATHOLOGICAL EVENTS
US7078167B2 (en) * 1999-09-17 2006-07-18 Agilent Technologies, Inc. Arrays having background features and methods for using the same
US7122303B2 (en) * 1999-09-17 2006-10-17 Agilent Technologies, Inc. Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same
US6544790B1 (en) * 1999-09-17 2003-04-08 Whitehead Institute For Biomedical Research Reverse transfection method
US20020006664A1 (en) * 1999-09-17 2002-01-17 Sabatini David M. Arrayed transfection method and uses related thereto
EP2343128A1 (en) * 1999-09-17 2011-07-13 BioArray Solutions Ltd. Substrate and chip for conducting bioassays
US6623936B1 (en) 1999-09-24 2003-09-23 Imgenex Compositions and methods for improved detection and classification of neoplasms
DE19946525A1 (en) * 1999-09-28 2001-05-03 Fraunhofer Ges Forschung Device for taking up and dispensing the smallest amounts of liquid
US6844151B1 (en) * 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
US6558623B1 (en) * 2000-07-06 2003-05-06 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
US7332275B2 (en) * 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US6607885B1 (en) 1999-10-15 2003-08-19 E. I. Du Pont De Nemours And Company Method for high-density microarray medicated gene expression profiling
US6709816B1 (en) * 1999-10-18 2004-03-23 Affymetrix, Inc. Identification of alleles
US6171797B1 (en) 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays
US20030036070A1 (en) * 1999-10-21 2003-02-20 Shukti Chakravarti Gene expression profiling of inflammatory bowel disease
JP2001186881A (en) * 1999-10-22 2001-07-10 Ngk Insulators Ltd Method for producing dna chip
US6656432B1 (en) * 1999-10-22 2003-12-02 Ngk Insulators, Ltd. Micropipette and dividedly injectable apparatus
JP2001186880A (en) * 1999-10-22 2001-07-10 Ngk Insulators Ltd Method for producing dna chip
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
US6689319B1 (en) 1999-10-29 2004-02-10 Agilent Technologies, Ind. Apparatus for deposition and inspection of chemical and biological fluids
WO2001032935A2 (en) * 1999-11-02 2001-05-10 Celine Hu Molecular microarrays and methods for production and use thereof
US6362004B1 (en) * 1999-11-09 2002-03-26 Packard Biochip Technologies, Llc Apparatus and method for using fiducial marks on a microarray substrate
AU2041901A (en) 1999-11-09 2001-06-06 Elitra Pharmaceuticals, Inc. Genes essential for microbial proliferation and antisense thereto
US7420046B2 (en) 1999-11-10 2008-09-02 Ceres, Inc. Sequence-determined DNA fragments encoding RNA polymerase proteins
US7109024B2 (en) * 1999-11-15 2006-09-19 Dr. Chip Biotechnology Inc. Biomolecule-bound substrates
US7041445B2 (en) 1999-11-15 2006-05-09 Clontech Laboratories, Inc. Long oligonucleotide arrays
GB2356063B (en) * 1999-11-22 2001-10-24 Genpak Ltd Adhesive label with grid for microscope slide
US6446642B1 (en) 1999-11-22 2002-09-10 Agilent Technologies, Inc. Method and apparatus to clean an inkjet reagent deposition device
AU4507201A (en) * 1999-11-24 2001-06-18 Incyte Genomics, Inc. Normalization controls and duplex probes for hybridization reactions
US6423535B1 (en) 1999-11-24 2002-07-23 Incyte Genomics, Inc. Normalization control for hybridization reactions
JP2001149060A (en) 1999-11-29 2001-06-05 Nisshinbo Ind Inc Nucleic acid-immobilized board
EP3379591A1 (en) * 1999-12-01 2018-09-26 The Trustees of Princeton University Complexes of form l2mx
EP1238095A4 (en) * 1999-12-16 2004-07-28 Univ Louisville Res Found Compositions and methods for caspase-induced apoptosis
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
CA2395335A1 (en) * 1999-12-23 2001-07-05 Elitra Pharmaceuticals, Inc. Genes identified as required for proliferation of e. coli
EP1255860A2 (en) 1999-12-29 2002-11-13 Mergen Ltd. Methods for amplifying and detecting multiple polynucleotides on a solid phase support
US6620625B2 (en) * 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
US20050118637A9 (en) * 2000-01-07 2005-06-02 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
US20070021929A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computing methods for control of high-throughput experimental processing, digital analysis, and re-arraying comparative samples in computer-designed arrays
CZ20022332A3 (en) * 2000-01-07 2003-01-15 Transform Pharmaceuticals, Inc. Sample assembly
US20040252299A9 (en) * 2000-01-07 2004-12-16 Lemmo Anthony V. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
US20050095696A9 (en) * 2000-01-07 2005-05-05 Lemmo Anthony V. Apparatus and method for high-throughput preparation and characterization of compositions
US20070020662A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest
US7108970B2 (en) * 2000-01-07 2006-09-19 Transform Pharmaceuticals, Inc. Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
US20050089923A9 (en) * 2000-01-07 2005-04-28 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
US7186813B1 (en) 2000-01-11 2007-03-06 Nanogen Recognomics Gmbh Biomolecules having multiple attachment moieties for binding to a substrate surface
WO2001051667A2 (en) 2000-01-14 2001-07-19 Integriderm, L.L.C. Informative nucleic acid arrays and methods for making same
US7429466B2 (en) * 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
US8143195B2 (en) * 2000-01-24 2012-03-27 Yingjian Wang Arrays for bringing two or more reagents in contact with one or more biological targets and methods for making and using the arrays
US20030097222A1 (en) * 2000-01-25 2003-05-22 Craford David M. Method, system, and computer software for providing a genomic web portal
US6587579B1 (en) * 2000-01-26 2003-07-01 Agilent Technologies Inc. Feature quality in array fabrication
US7355026B2 (en) 2000-01-27 2008-04-08 Ceres, Inc. Sequence-determined DNA fragments encoding SRF-type transcription factor proteins
CA2398107C (en) 2000-01-28 2013-11-19 Althea Technologies, Inc. Methods for analysis of gene expression
US6399396B1 (en) 2000-01-28 2002-06-04 Agilent Technologies, Inc. Compressed loading apparatus and method for liquid transfer
ATE411397T1 (en) * 2000-02-07 2008-10-15 Illumina Inc NUCLEIC ACID DETECTION METHOD WITH UNIVERSAL PRIMING
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
AU2001239760B2 (en) * 2000-02-10 2005-11-24 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6783985B1 (en) 2000-02-18 2004-08-31 Elitra Pharmaceuticals Inc. Gene disruption methodologies for drug target discovery
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US7160511B2 (en) 2000-02-18 2007-01-09 Olympus Corporation Liquid pipetting apparatus and micro array manufacturing apparatus
WO2001061054A2 (en) 2000-02-18 2001-08-23 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
CN1404415A (en) 2000-02-22 2003-03-19 基因谱公司 Microarray fabrication techniques and apparatus
WO2001062378A2 (en) * 2000-02-22 2001-08-30 Genospectra, Inc. Microarray fabrication techniques and apparatus
US20040014102A1 (en) * 2000-02-22 2004-01-22 Shiping Chen High density parallel printing of microarrays
AU2001256107A1 (en) * 2000-02-28 2001-09-03 Variom Biotechnology Ag Component comprising a plurality of fiber elements and sample molecules that areimmobilized on said fiber elements
WO2001062962A2 (en) * 2000-02-28 2001-08-30 Variom Biotechnology Ag Component for interaction analysis comprising probe molecule species which create co-operation effects
ITCA20000004A1 (en) * 2000-03-07 2001-09-07 Mario Raimondo Caria METHOD AND SYSTEM FOR SIMULTANEOUS AND MULTIPLE DETECTION WITH QUANTIFICATION OF THE HYBRIDIZATION OF MOLECULAR COMPOUNDS SUCH AS CORE ACIDS
US7087383B2 (en) * 2000-03-07 2006-08-08 Hisamitsu Pharmaceutical Co., Inc. Nucleic acid sequences showing enhanced expression in benign neuroblastoma compared with acritical human neuroblastoma
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
US6537433B1 (en) 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
US6447723B1 (en) 2000-03-13 2002-09-10 Packard Instrument Company, Inc. Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments
US20060252920A1 (en) 2001-08-10 2006-11-09 Nickolai Alexandrov Sequence-determined DNA fragments encoding cyclopropyl isomerase proteins
US6878554B1 (en) * 2000-03-20 2005-04-12 Perkinelmer Las, Inc. Method and apparatus for automatic pin detection in microarray spotting instruments
US6756232B1 (en) * 2000-03-20 2004-06-29 Perkinelmer Las, Inc. Method and apparatus for producing compact microarrays
US6376191B1 (en) 2000-03-22 2002-04-23 Mergen, Ltd. Microarray-based analysis of polynucleotide sequence variations
US6413722B1 (en) 2000-03-22 2002-07-02 Incyte Genomics, Inc. Polymer coated surfaces for microarray applications
JP4152054B2 (en) * 2000-03-23 2008-09-17 富士フイルム株式会社 Image reading device
US7829313B2 (en) * 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
KR100340126B1 (en) * 2000-03-24 2002-06-10 박한오 Automated Apparatus for Microarraying Biological Samples
US7202026B2 (en) * 2000-03-24 2007-04-10 Eppendorf Array Technologies Sa (Eat) Identification of a large number of biological (micro)organisms groups at different levels by their detection on a same array
US7875442B2 (en) * 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US20080085515A1 (en) * 2000-03-24 2008-04-10 Eppendorf Array Technologies Sa (Eat) Identification of multiple biological (micro) organisms by detection of their nucleotide sequences on arrays
US7205104B2 (en) * 2000-03-24 2007-04-17 Eppendorf Array Technologies Sa (Eat) Identification of biological (micro) organisms by detection of their homologous nucleotide sequences on arrays
JP2003529774A (en) * 2000-03-31 2003-10-07 ジェネンテック・インコーポレーテッド Compositions and methods for detecting and quantifying gene expression
US6800455B2 (en) * 2000-03-31 2004-10-05 Scios Inc. Secreted factors
WO2001075159A2 (en) * 2000-03-31 2001-10-11 Sir Mortimer B. Davis Jewish General Hospital Microchip arrays of regulatory genes
US20050003364A1 (en) * 2000-03-31 2005-01-06 Stanton Lawrence W. Secreted factors
JP4425420B2 (en) * 2000-04-03 2010-03-03 独立行政法人理化学研究所 Microarray production equipment
US6759235B2 (en) 2000-04-06 2004-07-06 Quantum Dot Corporation Two-dimensional spectral imaging system
DE10017105A1 (en) * 2000-04-06 2001-10-11 Basf Ag Method and device for producing biopolymer fields
GB0008563D0 (en) * 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
US7691991B2 (en) 2000-04-17 2010-04-06 Ceres, Inc. Sequence-determined DNA fragments encoding cytochrome P450 proteins
DE10020704B4 (en) * 2000-04-27 2006-09-28 Bioref Gmbh Biochip for archiving and laboratory medical analysis of biological sample material, process for its production and its use in diagnostic procedures
CA2408094A1 (en) * 2000-05-04 2001-11-08 The Center For Blood Research, Inc. Colloid compositions for solid phase biomolecular analytical, preparative and identification systems
US8399383B2 (en) 2000-05-04 2013-03-19 Yale University Protein chips for high throughput screening of protein activity
US6709840B1 (en) 2000-05-11 2004-03-23 The Board Of Trustees Of The Leland Stanford Junior University Anergy associated genes
US6902882B2 (en) 2000-05-23 2005-06-07 Kerong Gu Methods of monitoring production of gene products and uses thereof
CA2410950A1 (en) * 2000-05-30 2001-12-06 Hans-Michael Wenz Methods for detecting target nucleic acids using coupled ligation and amplification
US7700359B2 (en) * 2000-06-02 2010-04-20 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells
WO2003057926A1 (en) 2002-01-08 2003-07-17 Chiron Corporation Gene products differentially expressed in cancerous breast cells and their methods of use
WO2005000087A2 (en) * 2003-06-03 2005-01-06 Chiron Corporation Gene products differentially expressed in cancerous colon cells and their methods of use ii
US7521245B1 (en) 2000-06-05 2009-04-21 Perkinelmer Las, Inc. Method for washing and drying pins in microarray spotting instruments
US6455007B1 (en) * 2000-06-13 2002-09-24 Symyx Technologies, Inc. Apparatus and method for testing compositions in contact with a porous medium
US6660229B2 (en) 2000-06-13 2003-12-09 The Trustees Of Boston University Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
EP1164201A1 (en) * 2000-06-14 2001-12-19 Facultés Universitaires Notre-Dame de la Paix Reverse detection for identification and/or quantification of nucleotide target sequences on biochips
JP5363695B2 (en) 2000-06-15 2013-12-11 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Polynucleotides for colon cancer
US20040086877A1 (en) 2000-06-16 2004-05-06 Lal Preeti G. Multi-mode directi memory access controller and method
WO2001098458A2 (en) * 2000-06-19 2001-12-27 Zyomyx, Inc. Methods for immobilizing polypeptides
AU2001273057A1 (en) 2000-06-27 2002-01-08 Fluidigm Corporation A microfluidic design automation method and system
US7000622B2 (en) * 2002-09-30 2006-02-21 Lam Research Corporation Methods and systems for processing a bevel edge of a substrate using a dynamic liquid meniscus
US7234477B2 (en) * 2000-06-30 2007-06-26 Lam Research Corporation Method and apparatus for drying semiconductor wafer surfaces using a plurality of inlets and outlets held in close proximity to the wafer surfaces
US7584761B1 (en) 2000-06-30 2009-09-08 Lam Research Corporation Wafer edge surface treatment with liquid meniscus
US20030219816A1 (en) * 2001-07-02 2003-11-27 Keith Solomon Composite microarray slides
US7025933B2 (en) * 2000-07-06 2006-04-11 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
US6913879B1 (en) 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
US6890760B1 (en) * 2000-07-31 2005-05-10 Agilent Technologies, Inc. Array fabrication
US6613893B1 (en) 2000-07-31 2003-09-02 Agilent Technologies Inc. Array fabrication
US7205400B2 (en) * 2000-07-31 2007-04-17 Agilent Technologies, Inc. Array fabrication
US6599693B1 (en) 2000-07-31 2003-07-29 Agilent Technologies Inc. Array fabrication
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
EP1307285A2 (en) * 2000-08-03 2003-05-07 Massachusetts Institute Of Technology Microarrays of functional biomolecules, and uses therefor
US20020102617A1 (en) * 2000-08-03 2002-08-01 Macbeath Gavin Protein microarrays
US10106586B2 (en) 2000-08-07 2018-10-23 Ceres, Inc. Sequence-determined DNA fragments encoding peptide transport proteins
US7390893B2 (en) 2000-08-07 2008-06-24 Ceres, Inc. Sequence-determined DNA fragments encoding peptide transport proteins
US9085771B2 (en) 2001-01-03 2015-07-21 Ceres, Inc. Sequence-determined DNA fragments with regulatory functions
JP3398366B2 (en) * 2000-08-09 2003-04-21 富士写真フイルム株式会社 Method for producing microarray for DNA analysis
US7129229B2 (en) * 2000-08-11 2006-10-31 Nanogen Recognomics Gmbh Hydrazide building blocks and hydrazide modified biomolecules
ATE402760T1 (en) * 2000-08-15 2008-08-15 Bioforce Nanosciences Inc DEVICE FOR FORMING NANOMOLECULAR NETWORKS
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6789040B2 (en) 2000-08-22 2004-09-07 Affymetrix, Inc. System, method, and computer software product for specifying a scanning area of a substrate
US6965704B2 (en) * 2000-08-22 2005-11-15 Affymetrix, Inc. System, method, and computer software product for grid alignment of multiple scanned images
US20040161789A1 (en) * 2000-08-30 2004-08-19 Tanner Cameron W. Porous inorganic substrate for high-density arrays
US7608441B2 (en) 2000-08-31 2009-10-27 Ceres, Inc. Sequence-determined DNA fragments encoding sterol desaturase proteins
US20030190612A1 (en) * 2000-08-31 2003-10-09 Nobuko Yamamoto Detecting method and detection substrate for use therein
US9024004B2 (en) 2000-08-31 2015-05-05 Ceres, Inc. Sequence-determined DNA fragments encoding acetohydroxyacid synthase proteins
US20040185464A1 (en) * 2000-09-15 2004-09-23 Kris Richard M. High throughput assay system
AU2001292959A1 (en) * 2000-09-22 2002-04-02 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods and kits and systems for practicing the same
US7900505B2 (en) 2000-09-25 2011-03-08 Labcyte Inc. Acoustic assessment of fluids in a plurality of reservoirs
US6642061B2 (en) 2000-09-25 2003-11-04 Picoliter Inc. Use of immiscible fluids in droplet ejection through application of focused acoustic energy
ATE315957T1 (en) * 2000-09-25 2006-02-15 Picoliter Inc SOUND EXHAUST OF FLUID FROM SEVERAL CONTAINER
US20020037359A1 (en) 2000-09-25 2002-03-28 Mutz Mitchell W. Focused acoustic energy in the preparation of peptide arrays
US6548308B2 (en) 2000-09-25 2003-04-15 Picoliter Inc. Focused acoustic energy method and device for generating droplets of immiscible fluids
US20020061258A1 (en) * 2000-09-25 2002-05-23 Mutz Mitchell W. Focused acoustic energy in the preparation and screening of combinatorial libraries
JP4955901B2 (en) * 2000-09-25 2012-06-20 ピコリター インコーポレイテッド Focused acoustic energy method and device for generating droplets of immiscible fluids
JP4990476B2 (en) * 2000-09-25 2012-08-01 ピコリター インコーポレイテッド Focused acoustic energy in the preparation and screening of combinatorial libraries
US20030082604A1 (en) * 2000-09-27 2003-05-01 Swanson Melvin J. High density arrays
US20060141507A1 (en) * 2000-09-27 2006-06-29 Kronick Mel N Manufacture and use of non-standard size microarray slides
US6658324B2 (en) 2000-09-29 2003-12-02 Gpc Biotech Ag Pick and place robot system
AU2001296718A1 (en) 2000-10-06 2002-04-15 Novozymes A/S Methods for monitoring multiple gene expression
US8168773B2 (en) 2000-10-06 2012-05-01 Novozymes, Inc. Methods for monitoring multiple gene expression
AU1189702A (en) 2000-10-13 2002-04-22 Fluidigm Corp Microfluidic device based sample injection system for analytical devices
US6849409B2 (en) * 2000-10-16 2005-02-01 Axxima Pharmaceuticals Ag Cellular kinases involved in Cytomegalovirus infection and their inhibition
US7604971B2 (en) 2000-10-19 2009-10-20 Ceres, Inc. Sequence-determined DNA fragments encoding UBIE/COQ5 methyltransferase family proteins
JP2004512514A (en) * 2000-10-23 2004-04-22 ダイアチップ・リミテッド High precision intelligent biochip arrayer with re-spot function
US20020061538A1 (en) * 2000-10-26 2002-05-23 Rajan Kumar Fluidic arrays
EP1332000B1 (en) 2000-10-30 2012-06-20 Sequenom, Inc. Method for delivery of submicroliter volumes onto a substrate
US20020051995A1 (en) * 2000-10-30 2002-05-02 Rajan Kumar Stacked arrays
US7608704B2 (en) 2000-11-08 2009-10-27 Incyte Corporation Secreted proteins
US20020150887A1 (en) * 2000-11-09 2002-10-17 National Institute Of Advanced Industrial Science And Technology Methods and nucleic acid probes for molecular genetic analysis of polluted environments and environmental samples
US7033761B2 (en) 2000-11-14 2006-04-25 Shafer David A Expression miniarrays and uses thereof
US20020177138A1 (en) * 2000-11-15 2002-11-28 The United States Of America , Represented By The Secretary, Department Of Health And Human Services Methods for the indentification of textual and physical structured query fragments for the analysis of textual and biopolymer information
WO2002044695A1 (en) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US20030092009A1 (en) * 2000-11-16 2003-05-15 Kaia Palm Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease
US20050202470A1 (en) * 2000-11-16 2005-09-15 Caliper Life Sciences, Inc. Binding assays using molecular melt curves
US7026131B2 (en) * 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US7087203B2 (en) * 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
US6740530B1 (en) * 2000-11-22 2004-05-25 Xerox Corporation Testing method and configurations for multi-ejector system
JP2002153272A (en) * 2000-11-24 2002-05-28 Inst Of Physical & Chemical Res Biomolecule microarray
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
AU2002230523A1 (en) 2000-11-27 2002-06-03 Genevention L.L.C. Clinically intelligent diagnostic devices and methods
EP2336368A1 (en) 2000-12-07 2011-06-22 Novartis Vaccines and Diagnostics, Inc. Endogenous retroviruses up-regulated in prostate cancer
AU2002227255A1 (en) * 2000-12-08 2002-06-18 Ardais Corporation Container for cryopreserved material
US20040262318A1 (en) * 2000-12-08 2004-12-30 Ardais Corporation Container, method and system for cryptopreserved material
AU2002222618B2 (en) * 2000-12-12 2005-06-30 Masumi Abe Method of analyzing gene expression
EP1341934A4 (en) * 2000-12-12 2005-04-06 Autogenomics Inc Improved biochip
US6448387B1 (en) * 2000-12-18 2002-09-10 Monsanto Technology, Llc Polymeric arrays adapted for high expressing polynucleotides
WO2002051549A2 (en) * 2000-12-22 2002-07-04 Amersham Biosciences (Sv) Corp. High speed liquid deposition apparatus for microarray fabrication
US20020155473A1 (en) * 2000-12-22 2002-10-24 Zaoyuan Peng Methods for identifying G-protein coupled receptors associated with diseases
US7820447B2 (en) 2000-12-22 2010-10-26 Sagres Discovery Inc. Compositions and methods for cancer
US7700274B2 (en) 2000-12-22 2010-04-20 Sagres Discovery, Inc. Compositions and methods in cancer associated with altered expression of KCNJ9
US20030232334A1 (en) 2000-12-22 2003-12-18 Morris David W. Novel compositions and methods for cancer
US7892730B2 (en) 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
US7645441B2 (en) 2000-12-22 2010-01-12 Sagres Discovery Inc. Compositions and methods in cancer associated with altered expression of PRLR
US20030180953A1 (en) * 2000-12-29 2003-09-25 Elitra Pharmaceuticals, Inc. Gene disruption methodologies for drug target discovery
US7385046B2 (en) 2001-01-03 2008-06-10 Ceres, Inc. Sequence-determined DNA fragments encoding ethylene responsive element binding proteins
US7368555B2 (en) 2001-01-03 2008-05-06 Ceres, Inc. Sequence-determined DNA fragments encoding EF-hand calcium-binding proteins
JP3605039B2 (en) * 2001-01-09 2004-12-22 株式会社日立製作所 Nucleic acid microarray, method for producing the same, and method for detecting nucleic acid using the same
US7205161B2 (en) * 2001-01-10 2007-04-17 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate having improved stability
FR2819524B1 (en) * 2001-01-18 2003-07-04 Antonios Vekris DIFFERENTIAL COMPETITION HYBRIDIZATION
JP2005500008A (en) * 2001-01-19 2005-01-06 インサイト・ゲノミックス・インコーポレイテッド Receptors and membrane-bound proteins
CN1500144A (en) * 2001-02-06 2004-05-26 �����﹤����ʽ���� Amplified nucleic acids and immobilized products thereof
US7087389B2 (en) * 2001-02-09 2006-08-08 Council Of Scientific & Industrial Research Highly cost-effective analytical device for performing immunoassays with ultra high sensitivity
AU2002250078A1 (en) 2001-02-13 2002-08-28 Children`S Hospital Research Foundation Quantitative epstein barr virus pcr rapid assay
JP2004537032A (en) * 2001-02-16 2004-12-09 ペプスキャン　システムズ　ベー．フェー． Pixel array
AU2002245537B2 (en) 2001-02-23 2007-12-20 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US20050196785A1 (en) * 2001-03-05 2005-09-08 California Institute Of Technology Combinational array for nucleic acid analysis
JP2002262876A (en) * 2001-03-07 2002-09-17 Ngk Insulators Ltd Method for sensitively hybridizing nucleic acid, and method for analyzing gene using the method
US6605438B1 (en) * 2001-03-26 2003-08-12 Louis Dischler Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents
WO2002076401A2 (en) 2001-03-26 2002-10-03 Dana-Farber Cancer Institute, Inc. Method of attenuating reactions to skin irritants
JP3937742B2 (en) 2001-03-28 2007-06-27 キヤノン株式会社 Probe carrier and method for producing the same
JP2002286735A (en) 2001-03-28 2002-10-03 Canon Inc Liquid discharge device for manufacturing probe carrier, device for manufacturing probe carrier, and method for manufacturing probe carrier
US20020142341A1 (en) * 2001-03-28 2002-10-03 Makoto Kameyama Method and apparatus for producing probe carrier
US6869551B2 (en) * 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US7604976B2 (en) 2001-04-02 2009-10-20 Ceres, Inc. Sequence-determined DNA fragments encoding glutamine amidotransferase proteins
EP1384022A4 (en) 2001-04-06 2004-08-04 California Inst Of Techn Nucleic acid amplification utilizing microfluidic devices
US20020150944A1 (en) * 2001-04-06 2002-10-17 Fuji Photo Film Co., Ltd. Biochemical analysis unit and method for exposing stimulable phosphor sheet using the same
US20060129329A1 (en) * 2001-04-09 2006-06-15 Kobylecki Ryszard J Investigating different physical and/or chemical forms of materials
CA2443777A1 (en) 2001-04-10 2002-10-24 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic and diagnostic uses of antibody specificity profiles
US7033747B2 (en) 2001-04-11 2006-04-25 Nagaoka & Co., Ltd Multi-parameter assays including analysis discs and methods relating thereto
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
JP2005522980A (en) * 2001-04-23 2005-08-04 エリトラ ファーマシューティカルズ，インコーポレイテッド Identification and use of Aspergillus fumigatus essential genes
KR100777362B1 (en) * 2001-05-08 2007-11-19 (주)바이오니아 Spotting Pin for microarraying of biological preparation
US6852524B2 (en) 2001-04-27 2005-02-08 Canon Kabushiki Kaisha Probe carrier, probe fixing carrier and method of manufacturing the same
US6943036B2 (en) * 2001-04-30 2005-09-13 Agilent Technologies, Inc. Error detection in chemical array fabrication
CA2446417A1 (en) * 2001-05-03 2002-11-14 Sigma Genosys, L.P. Methods for assembling protein microarrays
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
KR100419002B1 (en) * 2001-05-11 2004-02-14 (주)로봇앤드디자인 An alignment apparatus for glass chip
US6558907B2 (en) 2001-05-16 2003-05-06 Corning Incorporated Methods and compositions for arraying nucleic acids onto a solid support
EP1445613B1 (en) 2001-05-21 2010-07-07 FUJIFILM Corporation Biochemical analysis unit and method for its production
US20040175710A1 (en) * 2001-05-22 2004-09-09 Haushalter Robert C. Method for in situ, on-chip chemical synthesis
WO2002097111A2 (en) * 2001-05-29 2002-12-05 Genomic Solutions, Inc. Method and apparatus for facilitating the creation and analysis of microarrays
AU2002312411A1 (en) * 2001-06-07 2002-12-16 Proligo Llc Microcalorimetric detection of analytes and binding events
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20020192657A1 (en) * 2001-06-19 2002-12-19 Erwin Robert L. Bio-tolerant substrata having analyte binding microarray
US7041257B2 (en) * 2001-09-25 2006-05-09 Cytonome, Inc. Microfabricated two-pin liquid sample dispensing system
CA2451637C (en) 2001-06-22 2013-04-23 Stemcells, Inc. Liver engrafting cells, assays, and uses thereof
US6855538B2 (en) * 2001-06-27 2005-02-15 The Regents Of The University Of California High-efficiency microarray printing device
US7402286B2 (en) * 2001-06-27 2008-07-22 The Regents Of The University Of California Capillary pins for high-efficiency microarray printing device
US7297480B2 (en) * 2001-06-28 2007-11-20 Dermtech International Method for detection of melanoma
US6989267B2 (en) * 2001-07-02 2006-01-24 Agilent Technologies, Inc. Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films
US6485918B1 (en) 2001-07-02 2002-11-26 Packard Bioscience Corporation Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate
US20030003493A1 (en) * 2001-07-02 2003-01-02 Fuji Photo Film Co., Ltd. Biochemical analysis unit and biochemical analysis kit
US6753145B2 (en) * 2001-07-05 2004-06-22 Agilent Technologies, Inc. Buffer composition and method for hybridization of microarrays on adsorbed polymer siliceous surfaces
US10272409B2 (en) 2001-07-11 2019-04-30 Michael E. Hogan Methods and devices based upon a novel form of nucleic acid duplex on a surface
EP1417337B1 (en) * 2001-07-11 2009-03-04 Baylor College of Medicine Methods and devices based upon a novel form of nucleic acid duplex on a surface
US20030013208A1 (en) * 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
AU2002329606A1 (en) * 2001-07-17 2003-03-03 Bioforce Nanosciences, Inc. Combined molecular blinding detection through force microscopy and mass spectrometry
US7402282B2 (en) 2001-07-20 2008-07-22 Ortho-Clinical Diagnostics, Inc. Auxiliary sample supply for a clinical analyzer
US20040006033A1 (en) * 2001-08-06 2004-01-08 Zhu York Yuan-Yuan Methods for identifying low-abundance polynucleotides and related compositions
US6787312B2 (en) * 2001-08-09 2004-09-07 Corning Incorporated Treatment of substrates for immobilizing biomolecules
WO2003013718A1 (en) * 2001-08-10 2003-02-20 Oxford Glycosciences (Uk) Ltd Liquid delivery apparatus and method
US20050019223A1 (en) * 2001-08-10 2005-01-27 Platt Albert Edward Liquid delivery apparatus and method
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US20050014147A1 (en) * 2001-08-21 2005-01-20 Hessner Martin J Method and apparatus for three label microarrays
JP2003135063A (en) * 2001-08-24 2003-05-13 Chiba Prefecture New gene nedl-1
JP4723133B2 (en) * 2001-08-24 2011-07-13 千葉県 Novel human BMCC1 gene
US7014744B2 (en) 2001-08-24 2006-03-21 Applera Corporation Method of purification and concentration using AC fields with a transfer tip
US6969489B2 (en) 2001-08-24 2005-11-29 Cytoplex Biosciences Micro array for high throughout screening
US20030087309A1 (en) * 2001-08-27 2003-05-08 Shiping Chen Desktop drug screening system
CA2356540A1 (en) * 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
WO2004050830A2 (en) * 2001-08-30 2004-06-17 Science And Technology Corporation @ University Of New Mexico Methods for covalently attaching proteins to substrates
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
AU2002331777A1 (en) * 2001-08-30 2003-03-18 Spectral Genomics, Inc. Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
US20050123913A1 (en) * 2001-08-30 2005-06-09 Emory University Human mitochondrial dna polymorphisms, haplogroups, associations with physiological conditions, and genotyping arrays
US20050147984A1 (en) * 2001-08-31 2005-07-07 Clondiag Chip Technologies Gmbh Interaction detection on several probe arrays
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
US20030113925A1 (en) * 2001-09-07 2003-06-19 Gordon John Francis Nuclear morphology based identification and quantification of white blood cell types using optical bio-disc systems
US20030106492A1 (en) * 2001-09-07 2003-06-12 Douglas Levinson Apparatus and method for high-throughput preparation, visualization and screening of compositions
US6955788B2 (en) * 2001-09-07 2005-10-18 Affymetrix, Inc. Apparatus and method for aligning microarray printing head
WO2003022028A2 (en) * 2001-09-10 2003-03-20 Meso Scale Technologies, Llc Methods, reagents, kits and apparatus for protein function analysis
US6974671B1 (en) 2001-09-12 2005-12-13 Salk Institute For Biological Studies Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
JP4226471B2 (en) 2001-09-18 2009-02-18 ファイブローゲン、インコーポレーテッド Method for analyzing connective tissue growth factor
US6670129B2 (en) 2001-09-24 2003-12-30 Corning Incorporated Cell transfection apparatus and methods for making and using the cell transfection apparatus
KR100443641B1 (en) * 2001-09-25 2004-08-09 김흥기 DNA stealth pin manufacture method
US7153699B2 (en) * 2001-12-21 2006-12-26 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
US20070054408A1 (en) * 2001-09-25 2007-03-08 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
US7042488B2 (en) 2001-09-27 2006-05-09 Fujinon Corporation Electronic endoscope for highlighting blood vessel
US20060056904A1 (en) * 2001-10-05 2006-03-16 Haselton Frederick R Capillary tube printing tips for microarray printing
CA2463725A1 (en) 2001-10-12 2003-11-06 Spectral Genomics, Inc. Compilations of nucleic acids and arrays and methods of using them
US7439346B2 (en) 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
US20030082560A1 (en) * 2001-10-29 2003-05-01 Yingjian Wang Method of making interactive protein arrays
US20030082294A1 (en) * 2001-10-31 2003-05-01 Laurakay Bruhn Surface treatment method for bio-arrays
US6866825B2 (en) 2001-11-05 2005-03-15 Industrial Technology Research Institute Micro-dispenser for biochemical analysis
CN100398551C (en) 2001-11-09 2008-07-02 乔治敦大学 Novel isoforms of vascular endothelial cell growth inhibitor
EP1451584B1 (en) * 2001-11-09 2011-05-11 3dbiosurfaces Technologies, LLC High surface area substrates for microarrays and methods to make same
US20030124599A1 (en) * 2001-11-14 2003-07-03 Shiping Chen Biochemical analysis system with combinatorial chemistry applications
WO2003044484A2 (en) * 2001-11-16 2003-05-30 Sloan-Kettering Institute For Cancer Research High-density cell microarrays for parallel functional determinations
EP1451358A2 (en) * 2001-11-20 2004-09-01 Genentech, Inc. Cell and tissue arrays and microarrays and methods of use
EP1448992A4 (en) * 2001-11-20 2005-11-02 Burstein Technologies Inc Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
AU2002351187A1 (en) 2001-11-30 2003-06-17 Fluidigm Corporation Microfluidic device and methods of using same
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
WO2003048727A2 (en) * 2001-12-03 2003-06-12 Invitrogen Corporation Identification of rearrangements in nucleic acid molecules
CN1602360A (en) 2001-12-06 2005-03-30 法布罗根股份有限公司 Methods of increasing endogenous erythropoietin (EPO)
EP2295060B1 (en) 2001-12-06 2018-10-31 Fibrogen, Inc. Treatment or prevention of ischemic or hypoxic conditions
US20070037147A1 (en) * 2001-12-07 2007-02-15 Pablo Garcia Endogenous retrovirus polypeptides linked to oncogenic transformation
AU2002366641A1 (en) 2001-12-11 2003-06-23 Fibrogen, Inc. Methods for inhibiting ocular processes
US7258839B2 (en) * 2001-12-21 2007-08-21 Cytonome, Inc. Temperature controlled microfabricated two-pin liquid sample dispensing system
US20030170694A1 (en) * 2001-12-21 2003-09-11 Daniel Wall Stabilized nucleic acids in gene and drug discovery and methods of use
US6846454B2 (en) * 2001-12-24 2005-01-25 Agilent Technologies, Inc. Fluid exit in reaction chambers
US20030124542A1 (en) * 2001-12-28 2003-07-03 Spectral Genomics, Inc. Methods for mapping the chromosomal loci of genes expressed by a cell
FR2834521B1 (en) * 2002-01-10 2004-12-17 Bio Merieux METHOD FOR DETECTION AND / OR IDENTIFICATION OF THE ORIGINAL ANIMAL SPECIES OF THE ANIMAL MATERIAL CONTAINED IN A SAMPLE
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
US20030143329A1 (en) * 2002-01-30 2003-07-31 Shchegrova Svetlana V. Error correction in array fabrication
DE60300424T2 (en) 2002-01-31 2006-03-09 Fuji Photo Film Co., Ltd., Minami-Ashigara Apparatus for carrying out biochemical analyzes and process for their preparation
KR100969209B1 (en) * 2002-01-31 2010-07-09 후지필름 가부시키가이샤 Producing method of unit for biochemical analysis
US7378492B2 (en) * 2002-02-20 2008-05-27 Incyte Corporation CD40-related receptor that binds CD40L
EP1520037A4 (en) * 2002-02-27 2006-06-07 Miragene Inc Improved substrate chemistry for protein immobilization on a rigid support
US20030161761A1 (en) * 2002-02-28 2003-08-28 Williams Roger O. Apparatus and method for composing high density materials onto target substrates by a rapid sequence
DE10229253A1 (en) * 2002-06-28 2004-01-29 Axaron Bioscience Ag Application of materials to substrates especially to form organic displays or arrays of spots of different composition (e.g. DNA and nucleotides) is effected using a capillary tube
WO2003076076A2 (en) * 2002-03-11 2003-09-18 Axaron Bioscience Ag Method for applying a substance to a substrate
WO2003076651A2 (en) * 2002-03-14 2003-09-18 Qlt Inc. Cancer associated araf1 protein kinase and its uses
US20040241723A1 (en) * 2002-03-18 2004-12-02 Marquess Foley Leigh Shaw Systems and methods for improving protein and milk production of dairy herds
EP2093233A1 (en) 2002-03-21 2009-08-26 Sagres Discovery, Inc. Novel compositions and methods in cancer
US6919531B2 (en) * 2002-03-25 2005-07-19 Agilent Technologies, Inc. Methods for producing glass substrates for use in biopolymeric microarrays
US6916621B2 (en) * 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
WO2003085379A2 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
US20040029151A1 (en) * 2002-04-09 2004-02-12 Affymetrix, Inc. Molecular genetic profiling of gleason grades 3 and 4/5 prostate cancer
US7687256B2 (en) * 2002-04-11 2010-03-30 Spire Corporation Surface activated biochip
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
BRPI0309391B1 (en) 2002-04-19 2018-10-30 Dsm Food Specialties B V vector comprising nucleic acid encoding phospholipase activity polypeptide, transformed cell, protein preparation, preparation method and related methods
KR100456213B1 (en) * 2002-05-02 2004-11-09 주식회사 가이아모 Micro-printing pen for microarray device
US20040072274A1 (en) * 2002-05-09 2004-04-15 Lebrun Stewart J. System and method for visualization and digital analysis of protein and other macromolecule microarrays
US6841379B2 (en) 2002-05-15 2005-01-11 Beckman Coulter, Inc. Conductive microplate
JP3732457B2 (en) * 2002-05-20 2006-01-05 日立ソフトウエアエンジニアリング株式会社 Spot pin
TWI221523B (en) * 2002-05-21 2004-10-01 Sony Corp Bioassay method, bioassay device, and bioassay substrate
US6980677B2 (en) * 2002-05-24 2005-12-27 Niles Scientific, Inc. Method, system, and computer code for finding spots defined in biological microarrays
US20060088447A1 (en) * 2002-05-28 2006-04-27 Pss Bio Instruments Specimen distributing device, coating part manufacturing method, specimen distributing method and substrate activating device
EP2275118A3 (en) 2002-05-29 2011-10-19 DeveloGen Aktiengesellschaft Pancreas-specific proteins
US20050239193A1 (en) * 2002-05-30 2005-10-27 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of microorganisms and microparticles
US7537936B2 (en) * 2002-05-31 2009-05-26 Agilent Technologies, Inc. Method of testing multiple fluid samples with multiple biopolymer arrays
US20040031167A1 (en) * 2002-06-13 2004-02-19 Stein Nathan D. Single wafer method and apparatus for drying semiconductor substrates using an inert gas air-knife
ATE545651T1 (en) * 2002-06-13 2012-03-15 Novartis Vaccines & Diagnostic VECTORS FOR EXPRESSING HML-2 POLYPEPTIDES
US7919308B2 (en) * 2002-06-14 2011-04-05 Agilent Technologies, Inc. Form in place gaskets for assays
EP1375678A3 (en) * 2002-06-14 2004-03-10 Agilent Technologies, Inc. Methods and compositions for performing array based assays
US9068173B2 (en) 2002-06-17 2015-06-30 Ceres, Inc. Sequence-determined DNA fragments encoding trehalose-6P phosphatase proteins
US20030231986A1 (en) * 2002-06-18 2003-12-18 Eastman Kodak Company Micro-array identification means
USH2223H1 (en) 2002-07-11 2008-09-02 The United States Of America As Represented By The Secretary Of The Navy Patterned, micrometer-sized antibody features
DE10329928A1 (en) * 2002-07-12 2004-02-05 Benq Corp., Kweishan Process for the preparation of biochips and biochip
JP2004045346A (en) * 2002-07-16 2004-02-12 Nisshinbo Ind Inc Microarray preparing method
CA2491023A1 (en) * 2002-07-19 2004-01-29 Althea Technologies, Inc. Strategies for gene expression analysis
US20040018497A1 (en) * 2002-07-26 2004-01-29 Warden Craig H Human obesity LIPIN3 polynucleotide and polypeptide sequences and methods of use thereof
US7105347B2 (en) 2002-07-30 2006-09-12 Corning Incorporated Method and device for protein delivery into cells
WO2004015393A2 (en) * 2002-08-13 2004-02-19 Discovery Partners International Spotting pattern for placement of compounds in an array
WO2004015396A2 (en) * 2002-08-13 2004-02-19 Incyte Corporation Cell adhesion and extracellular matrix proteins
WO2004016802A2 (en) * 2002-08-15 2004-02-26 Proteoplex, Inc. Methods and apparatus for preparing and assaying biological samples to determine protein concentration
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
US20030036085A1 (en) * 2002-08-19 2003-02-20 Salinaro Richard F Membranes
US8277753B2 (en) * 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
AU2003252591A1 (en) * 2002-08-30 2004-03-29 Japan Science And Technology Corporation Method of targeted gene disruption, genome of hyperthermostable bacterium and genome chip using the same
US20070219353A1 (en) * 2002-09-03 2007-09-20 Incyte Corporation Immune Response Associated Proteins
WO2004024895A2 (en) * 2002-09-16 2004-03-25 Plexxikon, Inc. Crystal structure of pim-1 kinase
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20040054160A1 (en) * 2002-09-16 2004-03-18 Santona Pal Nucleic-acid ink compositions for arraying onto a solid support
US6989234B2 (en) * 2002-09-24 2006-01-24 Duke University Method and apparatus for non-contact electrostatic actuation of droplets
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
WO2004028955A2 (en) 2002-09-25 2004-04-08 California Institute Of Technology Microfluidic large scale integration
US7383843B2 (en) * 2002-09-30 2008-06-10 Lam Research Corporation Method and apparatus for processing wafer surfaces using thin, high velocity fluid layer
US7389783B2 (en) * 2002-09-30 2008-06-24 Lam Research Corporation Proximity meniscus manifold
US7240679B2 (en) * 2002-09-30 2007-07-10 Lam Research Corporation System for substrate processing with meniscus, vacuum, IPA vapor, drying manifold
US7293571B2 (en) * 2002-09-30 2007-11-13 Lam Research Corporation Substrate proximity processing housing and insert for generating a fluid meniscus
US6988326B2 (en) * 2002-09-30 2006-01-24 Lam Research Corporation Phobic barrier meniscus separation and containment
US7997288B2 (en) * 2002-09-30 2011-08-16 Lam Research Corporation Single phase proximity head having a controlled meniscus for treating a substrate
US6988327B2 (en) * 2002-09-30 2006-01-24 Lam Research Corporation Methods and systems for processing a substrate using a dynamic liquid meniscus
US8236382B2 (en) * 2002-09-30 2012-08-07 Lam Research Corporation Proximity substrate preparation sequence, and method, apparatus, and system for implementing the same
US6954993B1 (en) 2002-09-30 2005-10-18 Lam Research Corporation Concentric proximity processing head
US7069937B2 (en) * 2002-09-30 2006-07-04 Lam Research Corporation Vertical proximity processor
US7513262B2 (en) * 2002-09-30 2009-04-07 Lam Research Corporation Substrate meniscus interface and methods for operation
US7045018B2 (en) * 2002-09-30 2006-05-16 Lam Research Corporation Substrate brush scrubbing and proximity cleaning-drying sequence using compatible chemistries, and method, apparatus, and system for implementing the same
US7153400B2 (en) * 2002-09-30 2006-12-26 Lam Research Corporation Apparatus and method for depositing and planarizing thin films of semiconductor wafers
US7367345B1 (en) 2002-09-30 2008-05-06 Lam Research Corporation Apparatus and method for providing a confined liquid for immersion lithography
US7632376B1 (en) 2002-09-30 2009-12-15 Lam Research Corporation Method and apparatus for atomic layer deposition (ALD) in a proximity system
US7093375B2 (en) * 2002-09-30 2006-08-22 Lam Research Corporation Apparatus and method for utilizing a meniscus in substrate processing
US7614411B2 (en) * 2002-09-30 2009-11-10 Lam Research Corporation Controls of ambient environment during wafer drying using proximity head
CA2500783C (en) * 2002-10-01 2012-07-17 Nimblegen Systems, Inc. Microarrays having multiple oligonucleotides in single array features
US8871446B2 (en) 2002-10-02 2014-10-28 California Institute Of Technology Microfluidic nucleic acid analysis
US20040067492A1 (en) * 2002-10-04 2004-04-08 Allan Peng Reverse transcription on microarrays
WO2004033636A2 (en) * 2002-10-04 2004-04-22 Incyte Corporation Protein modification and maintenance molecules
US20040235005A1 (en) * 2002-10-23 2004-11-25 Ernest Friedlander Methods and composition for detecting targets
US20040089750A1 (en) * 2002-10-23 2004-05-13 Muniswamappa Anjanappa Micro-array fluid dispensing apparatus and method
US20040082058A1 (en) * 2002-10-29 2004-04-29 Arthur Schleifer Array hybridization apparatus and method for making uniform sample volumes
US20040086868A1 (en) * 2002-10-30 2004-05-06 Parker Russell A. Enclosed arrays and their reading
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
AU2002952696A0 (en) 2002-11-14 2002-11-28 Genomics Research Partners Pty Ltd Status determination
EP1579005A4 (en) * 2002-11-15 2007-07-25 Sangamo Biosciences Inc Methods and compositions for analysis of regulatory sequences
US20070009516A1 (en) * 2002-11-26 2007-01-11 Tran Uyen K Immune response-associated proteins
CA2507189C (en) 2002-11-27 2018-06-12 Sequenom, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
US20040109045A1 (en) * 2002-12-06 2004-06-10 Eastman Kodak Company Print head for micro-deposition of bio-molecules
EP1572227B1 (en) 2002-12-16 2012-02-15 DeveloGen Aktiengesellschaft Pik4cb involved in the regulation of energy homeostasis
US7247337B1 (en) 2002-12-16 2007-07-24 Agilent Technologies, Inc. Method and apparatus for microarray fabrication
US20040121339A1 (en) * 2002-12-19 2004-06-24 Jizhong Zhou Special film-coated substrate for bio-microarray fabrication and use thereof
US7682565B2 (en) 2002-12-20 2010-03-23 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US20040120859A1 (en) * 2002-12-20 2004-06-24 Kocher Thomas E. Biomolecular micro-deposition system
JP5479663B2 (en) 2002-12-20 2014-04-23 セレラ コーポレーション Genetic polymorphism associated with myocardial infarction, detection method and use thereof
US7323555B2 (en) 2002-12-26 2008-01-29 Isao Saito Nucleotide derivative and DNA microarray
US7414117B2 (en) 2002-12-26 2008-08-19 Ngk Insulators, Ltd. Nucleotide derivative and DNA microarray
US20030166263A1 (en) * 2002-12-30 2003-09-04 Haushalter Robert C. Microfabricated spotting apparatus for producing low cost microarrays
WO2004060044A2 (en) * 2003-01-02 2004-07-22 Bioforce Nanosciences, Inc. Method and apparatus for molecular analysis in small sample volumes
US7029855B1 (en) * 2003-01-28 2006-04-18 Proteomyx Inc. Radioactive multiplexing analytical methods for biomarkers discovery
US7691580B2 (en) * 2003-01-29 2010-04-06 Corning Incorporated Reverse protein delivery into cells on coded microparticles
US20040151635A1 (en) * 2003-01-31 2004-08-05 Leproust Eric M. Array fabrication using deposited drop splat size
US20040152083A1 (en) * 2003-01-31 2004-08-05 Leproust Eric M. Multiple arrays with surface energy transition to maintain separation of samples on the arrays
US20040152081A1 (en) * 2003-01-31 2004-08-05 Leproust Eric M. Viscosity control during polynucleotide synthesis
US20050048573A1 (en) * 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
US7767387B2 (en) 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
US20070149449A1 (en) 2003-02-14 2007-06-28 Morris David W Therapeutic targets in cancer
US6861251B2 (en) * 2003-02-24 2005-03-01 Pritest, Inc. Translucent solid matrix assay device for microarray analysis
JP2007524374A (en) * 2003-02-28 2007-08-30 プレキシコン，インコーポレーテッド PYK2 crystal structure and use
US20040233250A1 (en) * 2003-03-05 2004-11-25 Haushalter Robert C. Microcontact printhead device
EP2194133B1 (en) 2003-03-06 2015-12-02 BASF Enzymes LLC Amylases, nucleic acids encoding them and methods for making and using them
MX295545B (en) 2003-03-07 2012-02-03 Diversa Corp Hydrolases, nucleic acids encoding them and mehods for making and using them.
EP1606419A1 (en) 2003-03-18 2005-12-21 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
DE10312628A1 (en) * 2003-03-21 2004-10-07 Friz Biochem Gmbh Method and device for wetting a substrate with a liquid
US20040248287A1 (en) * 2003-03-28 2004-12-09 Qianjin Hu Multi-array systems and methods of use thereof
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
MXPA05010681A (en) 2003-04-04 2005-12-15 Diversa Corp Pectate lyases, nucleic acids encoding them and methods for making and using them.
US7025935B2 (en) * 2003-04-11 2006-04-11 Illumina, Inc. Apparatus and methods for reformatting liquid samples
US8652774B2 (en) * 2003-04-16 2014-02-18 Affymetrix, Inc. Automated method of manufacturing polyer arrays
US7892745B2 (en) 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20040214310A1 (en) * 2003-04-25 2004-10-28 Parker Russell A. Apparatus and method for array alignment
AU2004235298A1 (en) * 2003-04-25 2004-11-11 Janssen Pharmaceutica N.V. Preservation of RNA in a biological sample
US7829682B1 (en) 2003-04-30 2010-11-09 Incyte Corporation Human β-adrenergic receptor kinase nucleic acid molecule
US7709610B2 (en) 2003-05-08 2010-05-04 Facet Biotech Corporation Therapeutic use of anti-CS1 antibodies
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
US20040223890A1 (en) * 2003-05-09 2004-11-11 Summers Douglas G. Clamshell slide holder
WO2004101808A2 (en) * 2003-05-09 2004-11-25 Sigma-Aldrich Co. Genomic and proteomic approaches for the development of cell culture medium
US8150627B2 (en) 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
US8150626B2 (en) * 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
PL1626276T3 (en) 2003-05-19 2019-09-30 Toray Industries, Inc. Support having selectively bonding substance fixed thereto
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
FR2855832B1 (en) * 2003-06-03 2007-09-14 Biomerieux Sa DIAGNOSTIC AND / OR PROGNOSTIC METHOD OF SEPTIC SYNDROME
US20050239089A1 (en) * 2003-06-06 2005-10-27 Johnson Martin D Mobility cassettes
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
ATE387961T1 (en) * 2003-06-17 2008-03-15 Moussa Hoummady DEVICE FOR REMOVING AND SEPARATING DROPS OF AT LEAST ONE LIQUID, METHOD OF USING THE DEVICE AND SERVO SYSTEM FOR THE METHOD
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
ATE556322T1 (en) 2003-06-20 2012-05-15 Universal Bio Research Co Ltd DEVICE FOR SAMPLE ARRAY AND FOR SAMPLE COMPOSITION, METHOD THEREFOR AND DEVICE USING SAMPLE COMPOSITION
US20040259261A1 (en) * 2003-06-20 2004-12-23 Phalanx Biotech Group, Inc. Method for manufacturing a microarray and verifying the same
US7675000B2 (en) * 2003-06-24 2010-03-09 Lam Research Corporation System method and apparatus for dry-in, dry-out, low defect laser dicing using proximity technology
US7960148B2 (en) 2003-07-02 2011-06-14 Verenium Corporation Glucanases, nucleic acids encoding them and methods for making and using them
WO2005003769A1 (en) * 2003-07-04 2005-01-13 Kubota Corporation Bio-chip
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
FR2857375B1 (en) * 2003-07-10 2007-11-09 Biomerieux Sa PROCESS FOR THE DETECTION AND / OR IDENTIFICATION OF STAPHYLOCOCCUS GENE BACTERIA
JP2005030869A (en) * 2003-07-10 2005-02-03 Fuji Photo Film Co Ltd Spot deposition method of probe solution
ES2392430T3 (en) 2003-07-11 2012-12-10 Develogen Aktiengesellschaft Use of DG153 segregated protein products to prevent and treat pancreatic diseases and / or obesity and / or metabolic syndrome
ZA200601330B (en) 2003-07-14 2010-10-27 Internat Livestock Res Inst East coast fever vaccine based on CTL-specific schizont antigens
US20050048571A1 (en) * 2003-07-29 2005-03-03 Danielson Paul S. Porous glass substrates with reduced auto-fluorescence
US20050026304A1 (en) * 2003-07-30 2005-02-03 Laurakay Bruhn Microarray based affinity purification and analysis device coupled with secondary analysis technologies
US8003317B2 (en) 2003-07-31 2011-08-23 Sequenom, Inc. Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions
US20050031488A1 (en) * 2003-08-06 2005-02-10 Hui Ge Sample array test slide with suspended membrane
WO2005014795A2 (en) 2003-08-08 2005-02-17 Genenews Inc. Osteoarthritis biomarkers and uses thereof
WO2005021714A2 (en) 2003-08-11 2005-03-10 Diversa Corporation Laccases, nucleic acids encoding them and methods for making and using them
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
WO2005017807A2 (en) * 2003-08-13 2005-02-24 Iconix Pharmaceuticals, Inc. Apparatus and method for classifying multi-dimensional biological data
EP1660870A2 (en) 2003-08-26 2006-05-31 Blueshift Biotechnologies, Inc. Time dependent fluorescence measurements
JP2005077284A (en) * 2003-09-01 2005-03-24 Seiko Epson Corp Manufacturing device and method for particle array, and method of detecting target substance
WO2005024068A2 (en) 2003-09-05 2005-03-17 Sequenom, Inc. Allele-specific sequence variation analysis
US7824856B2 (en) * 2003-09-10 2010-11-02 Althea Technologies, Inc. Expression profiling using microarrays
US20050060100A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company Computer software and algorithms for systems biologically linked to cellular phenotype
US20050164300A1 (en) * 2003-09-15 2005-07-28 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
US20050059083A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company High throughput method to identify ligands for cell attachment
US20050282177A1 (en) * 2003-09-22 2005-12-22 Aichi Prefecture Types of lymphoma and method for prognosis thereof
US7601532B2 (en) * 2003-09-25 2009-10-13 Hisamitsu Pharmaceutical Co., Inc. Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma
FR2860518B1 (en) * 2003-10-01 2006-02-17 Biomerieux Sa METHOD FOR THE DIAGNOSIS / PROGNOSIS OF NEUROBLASTOMA
JP2005114427A (en) * 2003-10-03 2005-04-28 Sony Corp Method for manufacturing substrate for bioassay by superposing two substrates one upon another and substrate for bioassay
AU2004288113A1 (en) * 2003-10-07 2005-05-19 Nathaniel Tue Tran Radioactive multiplexing analytical methods
EP1675682B1 (en) * 2003-10-24 2017-07-19 Aushon Biosystems, Inc. Apparatus and method for dispensing fluid, semi-solid and solid samples
CA2544178A1 (en) * 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal dna in amniotic fluid
WO2005049848A2 (en) * 2003-11-12 2005-06-02 Geneohm Sciences, Inc. Nucleic acid hybridization methods
FR2862239B1 (en) * 2003-11-14 2007-11-23 Commissariat Energie Atomique DEVICE FOR RECEIVING A SAMPLE OF FLUID, AND ITS APPLICATIONS
CA2546171A1 (en) 2003-11-17 2005-05-26 Tm Bioscience Corporation Method of detecting mutations associated with thrombosis
EP2135618B1 (en) 2003-11-19 2014-01-15 Evotec International GmbH SF6 for use in the treatment of diabetes and / or obesity, methods of screening for modulators and kit
JP5649263B2 (en) 2003-11-26 2015-01-07 セレラ コーポレーション Genetic polymorphisms associated with cardiovascular disorders and drug responses, methods for their detection and uses
EP2287341B1 (en) 2003-12-01 2013-02-13 Life Technologies Corporation Nucleic acid molecules containing recombination sites and methods of using the same
JP2005173484A (en) * 2003-12-15 2005-06-30 Canon Inc Image forming apparatus and process cartridge
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
JP5138938B2 (en) 2003-12-19 2013-02-06 プレキシコン インコーポレーテッド Compounds and methods for the development of RET modulators
EP1711618B1 (en) 2003-12-23 2010-08-04 Mount Sinai Hospital Corporation Methods for detecting markers associated with endometrial disease or phase
WO2005069762A2 (en) 2004-01-09 2005-08-04 Novozymes Inc. Bacillus licheniformis chromosome
EP1711517A4 (en) 2004-01-21 2008-02-13 Univ Utah Res Found MUTANT SODIUM CHANNEL NAv1.7 AND METHODS RELATED THERETO
US8017321B2 (en) 2004-01-23 2011-09-13 The Regents Of The University Of Colorado, A Body Corporate Gefitinib sensitivity-related gene expression and products and methods related thereto
WO2005081801A2 (en) * 2004-02-09 2005-09-09 Blueshift Biotechnologies, Inc. Methods and apparatus for scanning small sample volumes
BRPI0507929A (en) 2004-02-19 2007-07-17 Univ Alberta leptin promoter polymorphisms and their uses
ATE549352T1 (en) 2004-02-20 2012-03-15 Develogen Ag USE OF SECRETED PROTEIN PRODUCTS FOR THE PREVENTION AND TREATMENT OF PANCREATIC DISEASES AND/OR OBESITY AND/OR METABOLIC SYNDROME
US20050196761A1 (en) * 2004-03-08 2005-09-08 Thompson Allen C. Array hybridization apparatus and method
KR100590550B1 (en) * 2004-03-12 2006-06-19 삼성전자주식회사 A microarray having probe polynucleotide spots binding to a same target polynucleotide fragment maximally apart therebetween and a method of producing the same
CA2559171A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
JP4850061B2 (en) * 2004-03-18 2012-01-11 日水製薬株式会社 Antigen analyzer manufacturing method and analyzer
JP4420020B2 (en) * 2004-03-23 2010-02-24 東レ株式会社 How to stir the solution
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
CA2561381C (en) 2004-03-26 2015-05-12 Sequenom, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US20050214930A1 (en) * 2004-03-26 2005-09-29 Bynum Magdalena A Apparatus and method for preventing cross contamination when dissassembling an array
FR2868071B1 (en) * 2004-03-26 2006-06-09 Biomerieux Sa MARKING REAGENTS, METHODS FOR SYNTHESIZING SUCH REAGENTS AND METHODS FOR DETECTING BIOLOGICAL MOLECULES
JP2005283306A (en) * 2004-03-29 2005-10-13 Lintec Corp Member for manufacturing probe array, and manufacturing method for probe array
US7183057B2 (en) * 2004-03-31 2007-02-27 Dermtech International Tape stripping methods for analysis of skin disease and pathological skin state
US8062471B2 (en) * 2004-03-31 2011-11-22 Lam Research Corporation Proximity head heating method and apparatus
CN104774931B (en) 2004-03-31 2017-11-10 综合医院公司 Determine method of the cancer to EGF-R ELISA magnetic target therapy reactivity
US20050227239A1 (en) * 2004-04-08 2005-10-13 Joyce Timothy H Microarray based affinity purification and analysis device coupled with solid state nanopore electrodes
US7384779B2 (en) * 2004-04-12 2008-06-10 Corning Incorporated Porous substrate plates and the use thereof
ES2530694T3 (en) 2004-04-23 2015-03-04 Zoetis P & U Llc Cellular permissiveness factor for viruses, and uses thereof
WO2006001896A2 (en) * 2004-04-26 2006-01-05 Iconix Pharmaceuticals, Inc. A universal gene chip for high throughput chemogenomic analysis
EP1748846B1 (en) * 2004-04-30 2015-04-01 Bioforce Nanosciences, Inc. Method and apparatus for depositing material onto a surface
DE102004021904B4 (en) * 2004-05-04 2011-08-18 Carl Zeiss Microlmaging GmbH, 07745 Method and device for generating an analysis arrangement with discrete, separate measurement ranges for biological, biochemical or chemical analysis
JP2008503446A (en) 2004-05-06 2008-02-07 プレキシコン，インコーポレーテッド PDE4B inhibitor and use thereof
EP2423327B1 (en) 2004-05-07 2014-01-08 Celera Corporation Genetic polymorphism associated with liver fibrosis methods of detection and uses thereof
JP5149622B2 (en) * 2004-05-20 2013-02-20 クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド Single label comparative hybridization
JP5422120B2 (en) 2004-05-27 2014-02-19 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト Methods for predicting clinical outcome for epidermal growth factor receptor inhibitors by cancer patients
EP2471922A1 (en) 2004-05-28 2012-07-04 Asuragen, Inc. Methods and compositions involving microRNA
US7338763B2 (en) * 2004-06-02 2008-03-04 Eppendorf Array Technologies S.A. Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
EP2270034A3 (en) 2004-06-03 2011-06-01 Athlomics Pty Ltd Agents and methods for diagnosing stress
WO2005124650A2 (en) * 2004-06-10 2005-12-29 Iconix Pharmaceuticals, Inc. Sufficient and necessary reagent sets for chemogenomic analysis
ES2461857T3 (en) 2004-06-16 2014-05-21 Dsm Ip Assets B.V. Compositions and methods for enzymatic discoloration of chlorophyll
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
CA2570817A1 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
US7702466B1 (en) 2004-06-29 2010-04-20 Illumina, Inc. Systems and methods for selection of nucleic acid sequence probes
DE102004031177A1 (en) * 2004-06-29 2006-01-19 Henkel Kgaa New odoriferous gene products from Bacillus licheniformis and improved biotechnological production processes based on them
US20060003345A1 (en) 2004-06-30 2006-01-05 Pfizer Inc RNA bioassay
DE102004044179B4 (en) * 2004-06-30 2010-04-22 Osram Opto Semiconductors Gmbh Method for mounting semiconductor chips
CA2571823A1 (en) 2004-06-30 2006-01-12 Tm Bioscience Pgx, Inc. Method of detecting mutations in the gene encoding cytochrome p450-2d6
JP2008505321A (en) * 2004-07-02 2008-02-21 ブルーシフト・バイオテクノロジーズ・インコーポレーテッド Search for phosphor microenvironment
CN100496749C (en) * 2004-07-06 2009-06-10 犹他大学研究基金会 Spotting device and method for high concentration spot deposition on microarrays and other mini devices
US7588892B2 (en) * 2004-07-19 2009-09-15 Entelos, Inc. Reagent sets and gene signatures for renal tubule injury
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
EP2484780A1 (en) 2004-07-23 2012-08-08 The University of North Carolina At Chapel Hill Methods and materials for determining pain sensibility and predicting and treating related disorders
US20060105453A1 (en) 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
EP1623996A1 (en) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Improved method of selecting a desired protein from a library
RU2410438C2 (en) 2004-08-06 2011-01-27 Дженентек, Инк. Analyses and methods using biomarkers
JP5237638B2 (en) 2004-08-06 2013-07-17 ジェネンテック， インコーポレイテッド Assays and methods using biomarkers
CA2583428A1 (en) * 2004-09-03 2006-03-09 Plexxikon, Inc. Bicyclic heteroaryl pde4b inhibitors
WO2006029184A2 (en) 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
JP2006078356A (en) * 2004-09-10 2006-03-23 Yokogawa Electric Corp Biochip producing device
US20060059585A1 (en) 2004-09-14 2006-03-16 Boris Jankowski Modulating plant sugar levels
US20060108287A1 (en) * 2004-09-21 2006-05-25 Arnold Todd E Discrete zoned microporous nylon coated glass platform for use in microwell plates and methods of making and using same
US20060063274A1 (en) * 2004-09-23 2006-03-23 Schremp Donald J Methods for manufacturing and using chemical array calibration devices
US20080268437A1 (en) * 2004-09-27 2008-10-30 Wan Ji Method of Targeted and Comprehensive Sequencing Using High-Density Oligonucleotide Array
FR2876116B1 (en) * 2004-10-01 2007-04-06 Biomerieux Sa METHOD FOR GENERATING TRANSCRIPTS
US20060078896A1 (en) * 2004-10-12 2006-04-13 Peck Bill J Method, system, and computer program product to assess properties of a chemical array
FR2876705B1 (en) * 2004-10-19 2008-12-12 Biomerieux Sa METHOD FOR THE DIAGNOSIS OF ASPIRIN INTOLERANCE
EP1809765A2 (en) * 2004-11-04 2007-07-25 Roche Diagnostics GmbH Classification of acute myeloid leukemia
EP2322616A1 (en) 2004-11-12 2011-05-18 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
KR100624458B1 (en) * 2005-01-17 2006-09-19 삼성전자주식회사 Handheld centrifuge
EP1846760B1 (en) * 2005-01-27 2010-12-15 Quest Diagnostics Investments Incorporated Rapid comparative genome hybridization
EP1859330B1 (en) 2005-01-28 2012-07-04 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
FR2881437B1 (en) 2005-01-31 2010-11-19 Biomerieux Sa METHOD FOR THE DIAGNOSIS / PROGNOSIS OF A SEPTIC SYNDROME
CA2599589A1 (en) 2005-02-07 2006-08-17 Genenews,Inc. Mild osteoarthritis biomarkers and uses thereof
US20060199207A1 (en) * 2005-02-24 2006-09-07 Matysiak Stefan M Self-assembly of molecules using combinatorial hybridization
WO2006094049A2 (en) * 2005-03-01 2006-09-08 Parallel Synthesis Technologies, Inc. Polymeric fluid transfer and printing devices
US20090038023A1 (en) 2005-03-10 2009-02-05 Verenium Corporation Lyase Enzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them
CA2600794C (en) 2005-03-11 2014-08-12 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
AU2006227965B2 (en) 2005-03-15 2013-01-31 Bp Corporation North America Inc. Cellulases, nucleic acids encoding them and methods for making and using them
US20070092886A1 (en) * 2005-03-22 2007-04-26 Raymond Tabibiazar Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease
US20080020941A1 (en) 2005-03-24 2008-01-24 Jimpei Tabata Biomolecule-immobilized plate and method for fabricating biomolecule-immobilized plate
EP1866443A4 (en) * 2005-04-04 2009-04-08 Blueshift Biotechnologies Inc Screening using polarization anisotropy in fret emissions
US8076090B2 (en) 2005-04-05 2011-12-13 Corning Incorporated Label free biosensors and cells
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
JP2008535853A (en) 2005-04-07 2008-09-04 ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド Cancer-related genes
CA2604885A1 (en) 2005-04-07 2006-10-19 Guoying Yu Cacna1e in cancer diagnosis, detection and treatment
KR101363032B1 (en) 2005-04-18 2014-02-13 미토믹스 인크. Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
JP2008545652A (en) * 2005-05-17 2008-12-18 プレキシコン，インコーポレーテッド Compounds that modulate c-kit and c-fms activity and uses thereof
US8263414B2 (en) * 2005-05-23 2012-09-11 Siemens Healthcare Diagnostics Inc. Dispensing of a diagnostic liquid onto a diagnostic reagent
CA2611671C (en) 2005-06-15 2013-10-08 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
US20060286548A1 (en) * 2005-06-16 2006-12-21 Gregory Liposky Method of making recombinant human antibodies for use in biosensor technology
ES2371397T3 (en) * 2005-06-22 2011-12-30 Plexxikon, Inc. PIRROLO DERIVATIVES [2,3-B] PIRIDINE AS INHIBITORS OF PROTEIN KINES.
US20060292559A1 (en) * 2005-06-23 2006-12-28 Beckman Coulter, Inc. Cell-based microarrays, and methods for their preparation and use
EP1910565A4 (en) 2005-07-07 2009-10-28 Athlomics Pty Ltd Polynucleotide marker genes and their expression, for diagnosis of endotoxemia
CN1908189A (en) * 2005-08-02 2007-02-07 博奥生物有限公司 Method of external assistant identifying intestinal-type gastric cancer and differentiation degree thereof and special reagent case
ATE549416T1 (en) 2005-08-05 2012-03-15 Genentech Inc METHODS AND COMPOSITIONS FOR DETECTING AUTOIMMUNE DISEASES
CN101365951B (en) 2005-08-16 2013-09-11 健泰科生物技术公司 Apoptosis sensitivity to apo2l/trail by testing for 'galnac-t14 expression in cells/tissues
CA2619686A1 (en) * 2005-08-19 2007-02-22 Commomwealth Scientific And Industrial Research Organisation Arachnocampa luciferases
US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US8383059B2 (en) 2005-09-30 2013-02-26 University Of Utah Research Foundation Microfluidic interface for highly parallel addressing of sensing arrays
WO2007047408A2 (en) * 2005-10-12 2007-04-26 Pathologica, Llc. Promac signature application
WO2007053732A2 (en) 2005-11-01 2007-05-10 Mayo Foundation For Medical Education And Research Promoter polymorphisms of the blys gene and use in diagnostic methods
US20070105125A1 (en) * 2005-11-08 2007-05-10 Tsai George P Chemical array housing having a gas delivery element and methods of using the same
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
WO2007070252A2 (en) * 2005-11-30 2007-06-21 The University Of North Carolina At Chapel Hill Identification of genetic polymorphic variants associated with somatosensory disorders and methods of using the same
US7875274B2 (en) 2005-12-16 2011-01-25 The Board Of Trustees Of The Leland Stanford Junior University Protein modulators of resistance to alkylating agents
US20070161031A1 (en) * 2005-12-16 2007-07-12 The Board Of Trustees Of The Leland Stanford Junior University Functional arrays for high throughput characterization of gene expression regulatory elements
CN101437933B (en) 2005-12-28 2013-11-06 斯克里普斯研究所 Natural antisense and non-coding RNA transcripts as drug targets
US20070198653A1 (en) * 2005-12-30 2007-08-23 Kurt Jarnagin Systems and methods for remote computer-based analysis of user-provided chemogenomic data
CN101384757A (en) * 2006-01-03 2009-03-11 哈佛大学校长及研究员协会 Small molecule printing
EP1991274A4 (en) 2006-01-20 2009-06-10 Women S And Children S Health Method of treatment, prophylaxis and diagnosis of pathologies of the bone
US20070172840A1 (en) * 2006-01-26 2007-07-26 Lin Liu Parallel microarray hybridization
US8138123B2 (en) 2006-01-27 2012-03-20 Takeda Pharmaceutical Company Limited Gene expressing analysis tool
EP2216403A3 (en) 2006-02-02 2010-11-24 Verenium Corporation Esterases and related nucleic acids and methods
DK1989301T3 (en) 2006-02-10 2015-01-05 Bp Corp North America Inc Cellulolytic enzymes, nucleic acids encoding them, and methods for making and using them
CA2638801C (en) 2006-02-14 2016-12-13 Verenium Corporation Xylanases, nucleic acids encoding them and methods for making and using them
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8460878B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for detecting cells and cellular components in small defined volumes
MX2008011477A (en) 2006-03-07 2008-09-23 Cargill Inc Aldolases, nucleic acids encoding them and methods for making and using them.
EA019971B1 (en) 2006-03-07 2014-07-30 Верениум Корпорейшн Aldolases, nucleic acids encoding them and methods for making and using them
US20070232556A1 (en) * 2006-03-31 2007-10-04 Montine Thomas J Methods and compositions for the treatment of neurological diseases and disorders
US7914988B1 (en) 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
EP2044213A2 (en) 2006-04-24 2009-04-08 Genentech, Inc. Methods and compositions for detecting autoimmune disorders
AU2007244683A1 (en) 2006-04-27 2007-11-08 Pikamab, Inc. Methods and compositions for antibody therapy
JP2010527577A (en) 2006-05-22 2010-08-19 クリニカル ジェノミクス ピーティーワイ リミテッド Detection method
US8637436B2 (en) 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US9133504B2 (en) * 2006-06-05 2015-09-15 California Institute Of Technology Real time microarrays
WO2007142202A1 (en) 2006-06-06 2007-12-13 Panasonic Corporation Method of modifying nucleotide chain
US7928366B2 (en) * 2006-10-06 2011-04-19 Lam Research Corporation Methods of and apparatus for accessing a process chamber using a dual zone gas injector with improved optical access
US8663577B2 (en) 2006-07-12 2014-03-04 National Institute Of Advanced Industrial Science And Technology Variable pitch array spotter
WO2008008284A2 (en) 2006-07-14 2008-01-17 The Regents Of The University Of California Cancer biomarkers and methods of use threof
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
CN103397043A (en) 2006-08-04 2013-11-20 维莱尼姆公司 Glucanases, nucleic acids encoding same and method for making and using same
TWI316873B (en) * 2006-08-08 2009-11-11 Ind Tech Res Inst Apparatus of manufacturing biochip and manufacture method of biochip tip array
JP5244103B2 (en) 2006-08-09 2013-07-24 ホームステッド クリニカル コーポレイション Organ-specific protein and method of use thereof
US7993832B2 (en) 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US8813764B2 (en) 2009-05-29 2014-08-26 Lam Research Corporation Method and apparatus for physical confinement of a liquid meniscus over a semiconductor wafer
US20100021885A1 (en) * 2006-09-18 2010-01-28 Mark Fielden Reagent sets and gene signatures for non-genotoxic hepatocarcinogenicity
US20090131348A1 (en) 2006-09-19 2009-05-21 Emmanuel Labourier Micrornas differentially expressed in pancreatic diseases and uses thereof
WO2008036776A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
JP4692454B2 (en) * 2006-09-20 2011-06-01 パナソニック株式会社 Application member and application method
DK2617814T3 (en) 2006-09-21 2016-02-22 Basf Enzymes Llc Phytases, nucleic acids encoding them, and methods of producing and using them
CA2663001A1 (en) 2006-09-21 2008-03-27 Verenium Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US20080076139A1 (en) 2006-09-21 2008-03-27 Sharat Singh Methods and compositions for detecting the activation states of multiple signal transducers in rare circulating cells
WO2008034914A2 (en) 2006-09-22 2008-03-27 Clondiag Gmbh A dispenser device for and a method of dispensing a substance onto a substrate
US10753927B2 (en) 2006-09-22 2020-08-25 ALERE TECHNOLOGIES GmbH Methods for detecting an analyte
FR2906537A1 (en) * 2006-09-28 2008-04-04 Biomerieux Sa METHOD FOR IN VITRO DIAGNOSIS OF BRONCHO-PULMONARY CANCER BY DETECTION OF ALTERNATIVE MAJORITY TRANSCRIPTS OF KLK8 GENE ENCODING KALLICREIN 8 AND USE THEREOF FOR THE PROGNOSIS OF SURVIVAL
CA2915679C (en) 2006-10-20 2017-12-12 Celera Corporation Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
EP1914317A1 (en) * 2006-10-21 2008-04-23 Biolytix AG A method for qualitative and quantitative detection of short nucleic acid sequences of about 8 to 50 nucleotides in length
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
WO2008140484A2 (en) 2006-11-09 2008-11-20 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
EP2210898A1 (en) 2006-11-29 2010-07-28 Novozymes Inc. Bacillus Licheniformis chromosome
JP4307478B2 (en) * 2006-12-05 2009-08-05 キヤノン株式会社 Cartridge for biochemical reaction
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20121126A1 (en) * 2006-12-21 2012-08-24 Plexxikon Inc PIRROLO [2,3-B] PYRIDINES COMPOUNDS AS KINASE MODULATORS
EP2479267B1 (en) 2006-12-21 2016-12-21 BASF Enzymes LLC Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them
US8146902B2 (en) * 2006-12-21 2012-04-03 Lam Research Corporation Hybrid composite wafer carrier for wet clean equipment
WO2008080015A2 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
EP2136911A2 (en) 2007-01-19 2009-12-30 Biodot, Inc. Systems and methods for high speed array printing and hybridization
US8148147B2 (en) * 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
WO2008089994A1 (en) 2007-01-25 2008-07-31 Roche Diagnostics Gmbh Use of igfbp-7 in the assessment of heart failure
AR065544A1 (en) 2007-01-30 2009-06-17 Verenium Corp ENZYMES FOR THE TREATMENT OF NUCLEIC ACID LIGNOCELLULOSICS THAT CODE AND METHODS TO PREPARE AND USE THEM
EP2520668B1 (en) 2007-01-31 2014-12-24 Celera Corporation A molecular prognostic signature for predicting breast cancer distant metastasis, and uses thereof
US20080220983A1 (en) * 2007-03-08 2008-09-11 Switchgear Genomics A California Corporation Functional arrays for high throughput characterization of regulatory elements in untranslated regions of genes
ES2440740T3 (en) * 2007-03-08 2014-01-30 F. Hoffmann-La Roche Ag Use of SLIM-1 in the evaluation of heart failure
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
US8464736B1 (en) 2007-03-30 2013-06-18 Lam Research Corporation Reclaim chemistry
US7975708B2 (en) * 2007-03-30 2011-07-12 Lam Research Corporation Proximity head with angled vacuum conduit system, apparatus and method
EP2156179B1 (en) 2007-04-04 2021-08-18 The Regents of The University of California Methods for using a nanopore
CA2683804A1 (en) * 2007-04-13 2008-10-23 Dana Farber Cancer Institute, Inc. Receptor tyrosine kinase profiling
AU2008239594B2 (en) 2007-04-13 2013-10-24 Beth Israel Deaconess Medical Center Methods for treating cancer resistant to ErbB therapeutics
CA3017478A1 (en) 2007-04-27 2008-11-06 The Regents Of The University Of California Plant co2 sensors, nucleic acids encoding them, and methods for making and using them
EP2162459B1 (en) * 2007-05-01 2017-10-04 University of Miami Transcriptomic biomarkers for individual risk assessment in new onset heart failure
US20080274908A1 (en) * 2007-05-04 2008-11-06 Dermtech International Diagnosis of melanoma by nucleic acid analysis
US20100203051A1 (en) 2007-05-31 2010-08-12 The University Of Queensland Diagnostic markers for ankylosing spondylitis and uses thereof
AU2008260029B2 (en) 2007-05-31 2015-02-12 Yale University A genetic lesion associated with cancer
PE20090321A1 (en) 2007-06-04 2009-04-20 Genentech Inc ANTI-NOTCH1 NRR ANTIBODIES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION
FR2917090B1 (en) 2007-06-11 2012-06-15 Biomerieux Sa MARKING REAGENTS HAVING DIAZO AND NITRO FUNCTIONS, METHODS FOR SYNTHESIZING SUCH REAGENTS AND METHODS FOR DETECTING BIOLOGICAL MOLECULES
WO2008154813A1 (en) 2007-06-15 2008-12-24 Xiamen University Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and uses thereof
US8141566B2 (en) * 2007-06-19 2012-03-27 Lam Research Corporation System, method and apparatus for maintaining separation of liquids in a controlled meniscus
EP3009148B1 (en) 2007-07-02 2018-08-22 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
EP2666873B1 (en) 2007-07-12 2016-03-09 The Brigham and Women's Hospital, Inc. Compositions and methods for diagnosing and assessing inflammatory myopathies
WO2009012357A2 (en) 2007-07-17 2009-01-22 The General Hospital Corporation Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof
AU2008276063B2 (en) 2007-07-17 2013-11-28 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
ES2420973T3 (en) 2007-07-25 2013-08-28 University Of Louisville Research Foundation, Inc. Micro-RNA associated with exosome as a diagnostic marker
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
WO2009021233A2 (en) * 2007-08-09 2009-02-12 Advanced Liquid Logic, Inc. Pcb droplet actuator fabrication
EP2201374B1 (en) * 2007-08-30 2015-10-07 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
US8053198B2 (en) * 2007-09-14 2011-11-08 Meso Scale Technologies, Llc Diagnostic methods
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
MX2010003600A (en) 2007-10-03 2010-12-14 Verenium Corp Xylanases, nucleic acids encoding them and methods for making and using them.
CN102099485A (en) 2007-10-23 2011-06-15 临床基因组学有限公司 A method of diagnosing neoplasms - II
WO2009052573A1 (en) 2007-10-23 2009-04-30 Clinical Genomics Pty. Ltd. A method of diagnosing neoplasms
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
US8906700B2 (en) 2007-11-06 2014-12-09 Ambergen, Inc. Methods and compositions for phototransfer
US20090264298A1 (en) * 2007-11-06 2009-10-22 Ambergen, Inc. Methods for enriching subpopulations
US8932879B2 (en) * 2007-11-06 2015-01-13 Ambergen, Inc. Methods and compounds for phototransfer
US20090270278A1 (en) * 2007-11-06 2009-10-29 Ambergen, Inc. Methods and compounds for making arrays
US8481263B2 (en) * 2007-11-06 2013-07-09 Ambergen Bead-ligand-nascent protein complexes
US8486634B2 (en) 2007-11-06 2013-07-16 Ambergen, Inc. Amplifying bisulfite-treated template
US20090286286A1 (en) * 2007-11-06 2009-11-19 Ambergen , Inc. Methods for controlling amplification
AU2008323701B2 (en) 2007-11-07 2015-03-26 Genentech, Inc Methods and compositions for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies
US20100075374A1 (en) * 2007-11-08 2010-03-25 Ambergen, Inc. Methods for capturing nascent proteins
US20090131263A1 (en) * 2007-11-19 2009-05-21 Longying Dong Normalization methods for G-protein coupled receptor membrane array
US7892760B2 (en) 2007-11-19 2011-02-22 Celera Corporation Lung cancer markers, and uses thereof
US8003325B2 (en) 2007-11-30 2011-08-23 Mayo Foundation For Medical Education And Research Polymorphisms of the BLyS gene and use in diagnostic methods
US8440425B2 (en) * 2007-12-18 2013-05-14 Abbott Laboratories Method of preparing a biological specimen slide
US20110003708A1 (en) * 2007-12-27 2011-01-06 Compugen Ltd. Biomarkers for the prediction of renal injury
US8709772B2 (en) 2008-01-03 2014-04-29 Verenium Corporation Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
WO2009097508A2 (en) 2008-01-30 2009-08-06 Mcanulty, Jonathan Methods and compositions for wound healing
CA2618163A1 (en) 2008-02-07 2009-08-07 K. W. Michael Siu Head and neck cancer biomarkers
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
ES2398618T3 (en) 2008-02-25 2013-03-20 Nestec S.A. Drug selection for breast cancer therapy using antibody matrices
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
NZ602175A (en) 2008-03-28 2014-03-28 Mitomics Inc Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
DE102008018982A1 (en) * 2008-04-14 2009-11-05 Merz, Hartmut, Prof. Dr. med. Automatic device for carrying out detection reactions and method for dispensing reagents on microscope slides
US20090260458A1 (en) * 2008-04-17 2009-10-22 Victor Joseph High throughput dispenser
US9602777B2 (en) 2008-04-25 2017-03-21 Roche Diagnostics Hematology, Inc. Systems and methods for analyzing body fluids
WO2012030313A1 (en) 2008-04-25 2012-03-08 James Winkelman Method of determining a complete blood count and a white blood cell differential count
CA2722485C (en) * 2008-04-30 2018-02-13 F. Hoffmann-La Roche Ag Use of sfrp-3 in the assessment of heart failure
US20110118125A1 (en) * 2008-05-03 2011-05-19 Tufts Medical Center, Inc. Neonatal salivary genomics
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
JP2011520451A (en) 2008-05-14 2011-07-21 ダームテック インターナショナル Diagnosis of melanoma and Nikko Kuroko by nucleic acid analysis
EP2733222A1 (en) 2008-07-09 2014-05-21 Celera Corporation Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
FR2934595B1 (en) * 2008-07-29 2013-04-05 Biomerieux Sa MARKING REAGENTS HAVING A PYRIDINE CORE HAVING DIAZOMETHYL FUNCTION, METHODS FOR SYNTHESIZING SUCH REAGENTS AND METHODS FOR DETECTING BIOLOGICAL MOLECULES
WO2010017248A2 (en) 2008-08-04 2010-02-11 University Of Miami Sting (stimulator of interferon genes), a regulator of innate immune responses
US9182406B2 (en) * 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US20100086501A1 (en) * 2008-08-28 2010-04-08 Dermtech International Determining Age Ranges of Skin Samples
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
WO2010034010A2 (en) 2008-09-22 2010-03-25 Wasatch Microfluidics Microassay with internal referencing
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
EP2347265A1 (en) * 2008-10-17 2011-07-27 Roche Diagnostics GmbH Use of biglycan in the assessment of heart failure
CA2742324A1 (en) 2008-10-30 2010-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods for assessing rna patterns
US8539905B2 (en) * 2008-11-07 2013-09-24 The Research Foundation For The State University Of New York Polymeric micro-cantilevers for ultra-low volume fluid and living cell deposition
HUE032623T2 (en) 2008-11-11 2017-10-30 Univ Michigan Regents Anti-cxcr1 compositions and methods
GB0820822D0 (en) 2008-11-13 2008-12-24 Inst Catala D Oncologia Novel product and processes
ES2637063T3 (en) 2008-12-04 2017-10-10 Curna, Inc. Treatment of diseases related to tumor suppressor genes by inhibiting the natural antisense transcript to the gene
WO2010065792A2 (en) 2008-12-04 2010-06-10 Curna, Inc. Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo
JP5971948B2 (en) 2008-12-04 2016-08-17 クルナ・インコーポレーテッド Treatment of vascular endothelial growth factor (VEGF) -related diseases by suppression of natural antisense transcripts against VEGF
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
EP2382472B1 (en) 2008-12-23 2015-05-06 F.Hoffmann-La Roche Ag Methods and compositions for diagnostic use in cancer patients
PL2396038T3 (en) 2009-02-12 2016-05-31 Curna Inc Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
GB0903168D0 (en) 2009-02-25 2009-04-08 Fusion Antibodies Ltd Diagnostic method and kit
DK2406399T3 (en) 2009-03-09 2018-03-12 Bioatla Llc MIRAC PROTEINS
US9464287B2 (en) 2009-03-16 2016-10-11 Curna, Inc. Treatment of nuclear factor (erythroid-derived 2)-like 2 (NRF2) related diseases by inhibition of natural antisense transcript to NRF2
CA2755404C (en) 2009-03-17 2020-03-24 Joseph Collard Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1
JP5734947B2 (en) 2009-03-27 2015-06-17 ミトミクス インコーポレイテッドＧｅｎｅｓｉｓ Ｇｅｎｏｍｉｃｓ Ｉｎｃ． Abnormal mitochondrial DNA, related fusion transcripts and translation products, and hybridization probes thereof
AR078033A1 (en) 2009-04-03 2011-10-12 Plexxikon Inc A SOLID DISPERSION, CONTAINING THE COMPOUND {3- [5- (4- (CHLORINE-PHENYL) -1H-PIRROLO [2,3-B] PIRIDINA-3-CARBONIL] -2,4-DIFLUOR-PHENIL} -AMIDA OF PROPANE-1-SULPHONIC ACID, COMPOSITIONS AND FORMULATIONS THAT INCLUDE SUCH SOLID DISPERSION; METHODS FOR MANUFACTURING SUCH SOLID DISPERSION, FORMS 1 AND 2
US20100297127A1 (en) 2009-04-08 2010-11-25 Ghilardi Nico P Use of il-27 antagonists to treat lupus
BRPI1011394A8 (en) 2009-04-18 2018-06-26 Genentech Inc method for assessing B cell linforma responsiveness to anti-cd40 antibody treatment
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
WO2010127057A2 (en) 2009-05-01 2010-11-04 Meso Scale Technologies, Llc. Biomarkers of therapeutic responsiveness
ES2609655T3 (en) 2009-05-06 2017-04-21 Curna, Inc. Treatment of diseases related to tristetraproline (TTP) by inhibition of natural antisense transcript for TTP
CN106237345A (en) 2009-05-06 2016-12-21 库尔纳公司 By suppression therapy lipid transfer and the metabolic gene relevant disease of the natural antisense transcript for lipid transfer and metabolic gene
ES2618572T3 (en) 2009-05-08 2017-06-21 Curna, Inc. Treatment of diseases related to the dystrophin family by inhibiting a natural antisense transcript for the dmd family
US20120058916A1 (en) 2009-05-13 2012-03-08 Meso Scale Technologies, Llc. Diagnostic methods for liver disorders
JP5922017B2 (en) 2009-05-18 2016-05-24 クルナ・インコーポレーテッド Treatment of reprogramming factor-related diseases by suppression of natural antisense transcripts against the reprogramming factor
NZ596459A (en) 2009-05-21 2013-11-29 Verenium Corp Phytases, nucleic acids encoding them and methods for making and using them
WO2010135695A2 (en) 2009-05-22 2010-11-25 Curna, Inc. TREATMENT OF TRANSCRIPTION FACTOR E3 (TFE3) and INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO TFE3
EP2435571B1 (en) 2009-05-28 2016-12-14 CuRNA, Inc. Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
WO2010138456A2 (en) 2009-05-29 2010-12-02 The Regents Of The University Of California B cell signature associated with tolerance in transplant recipients
WO2010141546A1 (en) 2009-06-02 2010-12-09 University Of Miami Diagnostic transcriptomic biomakers in inflammatory cardiomyopathies
ES2623633T3 (en) 2009-06-09 2017-07-11 Gendiag.Exe, S.L. Risk markers for cardiovascular disease
KR101801404B1 (en) 2009-06-16 2017-12-20 큐알엔에이, 인크. Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
ES2629339T3 (en) 2009-06-16 2017-08-08 Curna, Inc. Treatment of diseases related to paraoxonase 1 (pon1) by inhibition of natural antisense transcript to pon1
US8367334B2 (en) * 2009-06-18 2013-02-05 The Penn State Research Foundation Methods, systems and kits for detecting protein-nucleic acid interactions
CA2765889A1 (en) 2009-06-24 2010-12-29 Opko Curna, Llc Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
EP2446056A2 (en) 2009-06-25 2012-05-02 Yale University Single nucleotide polymorphisms in brca1 and cancer risk
KR101807324B1 (en) 2009-06-26 2017-12-08 큐알엔에이, 인크. Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
AU2010273585B2 (en) 2009-07-13 2015-04-23 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
JP5795311B2 (en) 2009-07-15 2015-10-14 ネステク ソシエテ アノニム Drug selection for gastric cancer therapy using antibody-based arrays
CN102712925B (en) 2009-07-24 2017-10-27 库尔纳公司 It is diseases related that SIRTUIN (SIRT) is treated by suppressing SIRTUIN (SIRT) natural antisense transcript
ES2512018T3 (en) 2009-07-27 2014-10-23 F. Hoffmann-La Roche Ag Use of mimecan in the evaluation of heart failure
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
CA2769665A1 (en) 2009-08-05 2011-02-10 Opko Curna, Llc Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
EP2772761A3 (en) 2009-08-07 2014-12-10 NEC Soft, Ltd. Nucleic acid element for use in analysis, and analytical method, analytical reagent and analytical instrument using same
EP2464731B1 (en) 2009-08-11 2016-10-05 CuRNA, Inc. Treatment of adiponectin (adipoq) related diseases by inhibition of natural antisense transcript to an adiponectin (adipoq)
MX2012001716A (en) 2009-08-14 2012-04-02 Genentech Inc Biological markers for monitoring patient response to vegf antagonists.
WO2011022606A2 (en) 2009-08-21 2011-02-24 Curna, Inc. Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip
KR101892760B1 (en) 2009-08-25 2018-08-28 큐알엔에이, 인크. Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
US8815779B2 (en) 2009-09-16 2014-08-26 SwitchGear Genomics, Inc. Transcription biomarkers of biological responses and methods
ES2530732T3 (en) 2009-09-17 2015-03-05 Hoffmann La Roche Diagnostic procedures for lung cancer
WO2011032296A1 (en) 2009-09-21 2011-03-24 Mount Sinai Hospital Methods and compositions for the diagnosis and treatment of thyroid cancer
CN102791861B (en) 2009-09-25 2018-08-07 库尔纳公司 FLG relevant diseases are treated by adjusting expression and the activity of Filaggrin (FLG)
AU2010298000A1 (en) 2009-09-25 2012-04-05 Signature Genomics Laboratories Llc Multiplex (+/-) stranded arrays and assays for detecting chromosomal abnormalities associated with cancer and other diseases
US9927435B2 (en) 2009-10-15 2018-03-27 Robert Bosch Gmbh Multisite biosensor and associated method
UA109884C2 (en) 2009-10-16 2015-10-26 A POLYPEPTIDE THAT HAS THE ACTIVITY OF THE PHOSPHATIDYLINOSYTOL-SPECIFIC PHOSPHOLIPASE C, NUCLEIC ACID, AND METHOD OF METHOD
UA111708C2 (en) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. METHOD OF OIL REFINING
US20120322677A1 (en) 2009-10-19 2012-12-20 Stichting Het Nederlands Kanker Instituut Predicting benefit of anti-cancer therapy via array comparative genomic hybridization
EP2491140A1 (en) 2009-10-19 2012-08-29 Stichting Het Nederlands Kanker Instituut Predicting response to anti-cancer therapy via array comparative genomic hybridization
US20120316080A1 (en) 2009-10-19 2012-12-13 Stichting Het Nederlands Kanker Instiuut Differentiation between brca2-associated tumours and sporadic tumours via array comparative genomic hybridization
WO2011049964A1 (en) 2009-10-19 2011-04-28 Lab Scientific Group Rna detection and quantitation
NZ599460A (en) 2009-10-20 2014-07-25 Nestec Sa Proximity-mediated assays for detecting oncogenic fusion proteins
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
NZ599866A (en) 2009-11-06 2014-09-26 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
CA2780875A1 (en) 2009-11-13 2011-05-19 Pangaea Biotech, S.L. Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
ES2661813T3 (en) 2009-12-16 2018-04-04 Curna, Inc. Treatment of diseases related to membrane transcription factor peptidase, site 1 (mbtps1) by inhibition of the natural antisense transcript to the mbtps1 gene
PL2516465T3 (en) 2009-12-23 2016-11-30 Anti-bv8 antibodies and uses thereof
WO2011079261A2 (en) 2009-12-23 2011-06-30 Curna, Inc. Treatment of hepatocyte growth factor (hgf) related diseases by inhibition of natural antisense transcript to hgf
EP2515947B1 (en) 2009-12-23 2021-10-06 CuRNA, Inc. Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
JP5982288B2 (en) 2009-12-29 2016-08-31 カッパーアールエヌエー，インコーポレイテッド Treatment of tumor protein 63-related diseases by inhibition of natural antisense transcripts against tumor protein 63 (p63)
RU2615450C2 (en) 2009-12-29 2017-04-04 Курна, Инк. Treating diseases associated with nuclear respiratory factor 1 (nrf1) by inhibition of natural antisense transcript to nrf1
EP2519260A2 (en) 2009-12-31 2012-11-07 Deutsches Krebsforschungszentrum Novel modulators of trail signalling
EP2519632B1 (en) 2009-12-31 2018-04-11 CuRNA, Inc. Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)
DK2521784T3 (en) 2010-01-04 2018-03-12 Curna Inc TREATMENT OF INTERFERON REGULATORY FACTOR 8- (IRF8) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPT TO IRF8
JP5963680B2 (en) 2010-01-06 2016-08-03 カッパーアールエヌエー，インコーポレイテッド Treatment of pancreatic developmental gene diseases by inhibition of natural antisense transcripts against pancreatic developmental genes
WO2011085347A2 (en) 2010-01-11 2011-07-14 Opko Curna, Llc Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg
EP2524232B1 (en) 2010-01-12 2014-08-06 Nestec S.A. Methods for predicting response of triple-negative breast cancer to therapy
US11275084B2 (en) 2010-01-15 2022-03-15 Stanford University Successive sampling device and associated method
JP5691178B2 (en) * 2010-01-22 2015-04-01 凸版印刷株式会社 Dispensing method and dispensing apparatus
ES2671877T3 (en) 2010-01-25 2018-06-11 Curna, Inc. Treatment of diseases related to RNASA (H1) by inhibition of the natural antisense transcript to RNASA H1
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
US8648016B2 (en) 2010-02-08 2014-02-11 Robert Bosch Gmbh Array with extended dynamic range and associated method
CN102844435B (en) 2010-02-22 2017-05-10 库尔纳公司 Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
ES2544635T3 (en) 2010-03-01 2015-09-02 Quanterix Corporation Methods to extend the dynamic range in assays for the detection of molecules or particles
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
WO2011108930A1 (en) 2010-03-04 2011-09-09 Interna Technologies Bv A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT
RU2612884C2 (en) 2010-04-02 2017-03-13 Курна, Инк. Treatment of diseases associated with colonystimulating factor 3 (csf3) by inhibition of natural antisense transcript to csf3
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
WO2011127099A1 (en) 2010-04-05 2011-10-13 Prognosys Biosciences, Inc. Spatially encoded biological assays
EP2556160A4 (en) 2010-04-09 2013-08-21 Curna Inc Treatment of fibroblast growth factor 21 (fgf21) related diseases by inhibition of natural antisense transcript to fgf21
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
WO2011133450A2 (en) 2010-04-19 2011-10-27 Meso Scale Technologies, Llc. Serology assays
US20120003639A1 (en) 2010-04-27 2012-01-05 Prelude, Inc. Cancer biomarkers and methods of use thereof
WO2011139387A1 (en) 2010-05-03 2011-11-10 Opko Curna, Llc Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
US20110275530A1 (en) 2010-05-04 2011-11-10 Paul Walfish Methods and compositions for the diagnosis and treatment of epithelial cancers
US9188585B2 (en) 2010-05-13 2015-11-17 Robert Bosch Gmbh Device and method for indirect modulation of detection environment
TWI586356B (en) 2010-05-14 2017-06-11 可娜公司 Treatment of par4 related diseases by inhibition of natural antisense transcript to par4
KR20180053419A (en) 2010-05-26 2018-05-21 큐알엔에이, 인크. Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1
EP2576784B1 (en) 2010-05-26 2017-11-15 CuRNA, Inc. Treatment of methionine sulfoxide reductase a (msra) related diseases by inhibition of natural antisense transcript to msra
WO2011153224A2 (en) 2010-06-02 2011-12-08 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
EP2576837B1 (en) 2010-06-04 2017-09-06 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
WO2011150976A1 (en) 2010-06-04 2011-12-08 bioMérieux Method and kit for the prognosis of colorectal cancer
WO2011154139A2 (en) 2010-06-07 2011-12-15 Roche Diagnostics Gmbh Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
CN103153346A (en) 2010-06-16 2013-06-12 戴纳瓦克斯技术公司 Methods of treatment using tlr7 and/or tlr9 inhibitors
US9353412B2 (en) 2010-06-18 2016-05-31 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
EP2400304A1 (en) 2010-06-22 2011-12-28 Centro de Investigación Cooperativa En Biomateriales ( CIC biomaGUNE) Method for the characterization of intermolecular interactions
WO2011163499A2 (en) 2010-06-23 2011-12-29 Opko Curna, Llc Treatment of sodium channel, voltage-gated, alpha subunit (scna) related diseases by inhibition of natural antisense transcript to scna
CA2804599C (en) 2010-07-06 2023-01-31 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
WO2012009402A2 (en) 2010-07-14 2012-01-19 Opko Curna Llc Treatment of discs large homolog (dlg) related diseases by inhibition of natural antisense transcript to dlg
WO2012021969A1 (en) 2010-08-16 2012-02-23 Mount Sinai Hospital Markers of the male urogenital tract
EP2616554A1 (en) 2010-09-17 2013-07-24 President and Fellows of Harvard College Functional genomics assay for characterizing pluripotent stem cell utility and safety
WO2012038837A2 (en) 2010-09-20 2012-03-29 Stichting Het Nederlands Kanker Instituut Methods for predicting response to anti-cancer therapy in cancer patients
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
CA2811789A1 (en) 2010-10-06 2012-04-12 Bp Corporation North America Inc. Variant cbh i polypeptides with reduced product inhibition
CA2813901C (en) 2010-10-06 2019-11-12 Curna, Inc. Treatment of sialidase 4 (neu4) related diseases by inhibition of natural antisense transcript to neu4
EP2630241B1 (en) 2010-10-22 2018-10-17 CuRNA, Inc. Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
WO2012068400A2 (en) 2010-11-17 2012-05-24 Asuragen, Inc. Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms
US10000752B2 (en) 2010-11-18 2018-06-19 Curna, Inc. Antagonat compositions and methods of use
ES2657590T3 (en) 2010-11-23 2018-03-06 Curna, Inc. Treatment of nanog related diseases by inhibiting the natural antisense transcript to nanog
US20120302456A1 (en) * 2010-11-23 2012-11-29 President And Fellows Of Harvard College Vertical flow-through devices for multiplexed elisa driven by wicking
JP2014506117A (en) 2010-11-24 2014-03-13 エフ．ホフマン−ラ ロシュ アーゲー Method for detecting mild inflammation
CN103384828A (en) 2010-12-23 2013-11-06 雀巢产品技术援助有限公司 Drug selection for malignant cancer therapy using antibody-based arrays
CN103270417A (en) 2010-12-24 2013-08-28 Nec软件有限公司 Analytical device and analytical method
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
WO2012100205A2 (en) 2011-01-21 2012-07-26 Biodot, Inc. Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
WO2012106514A2 (en) 2011-02-03 2012-08-09 Pop Test Cortisol Llc System and method for diagnosis and treatment
PE20141360A1 (en) 2011-02-07 2014-10-13 Plexxikon Inc COMPOUNDS AND METHODS FOR THE MODULATION OF KINASES AND INDICATIONS FOR THEM.
EP2673728B1 (en) 2011-02-08 2018-09-12 dacadoo ag System, method and apparatus for the remote analysis of chemical compound microarrays
TWI558702B (en) 2011-02-21 2016-11-21 普雷辛肯公司 Solid forms of a pharmaceutically active substance
EP2492688A1 (en) 2011-02-23 2012-08-29 Pangaea Biotech, S.A. Molecular biomarkers for predicting response to antitumor treatment in lung cancer
US20140057295A1 (en) 2011-02-28 2014-02-27 Barbara J. Stegmann Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
CA2826838A1 (en) 2011-03-11 2012-09-20 F.Hoffmann-La Roche Ag Seprase as marker for chronic obstructive pulmonary disease (copd)
CN103403556B (en) 2011-03-11 2015-06-24 霍夫曼-拉罗奇有限公司 ARMET as marker for chronic obstructive pulmonary disease (COPD)
WO2012123299A1 (en) 2011-03-11 2012-09-20 Roche Diagnostics Gmbh Asc as marker for chronic obstructive pulmonary disease (copd)
EP2684052B1 (en) 2011-03-11 2016-04-27 Roche Diagniostics GmbH Apex1 as marker for chronic obstructive pulmonary disease (copd)
WO2012123297A1 (en) 2011-03-11 2012-09-20 Roche Diagnostics Gmbh Nnmt as marker for chronic obstructive pulmonary disease (copd)
CN103415771B (en) 2011-03-11 2015-04-22 霍夫曼-拉罗奇有限公司 Fen1 as marker for chronic obstructive pulmonary disease (copd)
WO2012129347A1 (en) 2011-03-21 2012-09-27 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
WO2012130731A1 (en) 2011-03-25 2012-10-04 Roche Diagnostics Gmbh MEASUREMENT OF C-TERMINAL proSP-B
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
US20120258871A1 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
WO2012149267A1 (en) 2011-04-27 2012-11-01 Yale University Drug therapy to inhibit chemotherapy-induced adverse effects and related pharmaceutical compositions, diagnostics, screening techniques and kits
RU2631487C2 (en) 2011-05-17 2017-09-22 Плексксикон Инк. Kinases modulation and indications for its use
RU2620980C2 (en) 2011-06-09 2017-05-30 Курна, Инк. Treatment of diseases associated with frataxin (fxn), by inhibiting natural antisense fxn transcript
EP2718465B1 (en) 2011-06-09 2022-04-13 Illumina, Inc. Method of making an analyte array
US10711308B2 (en) 2011-06-17 2020-07-14 Brigham And Women's Hospital, Inc. Mutation signatures for predicting the survivability of myelodysplastic syndrome subjects
JP5863794B2 (en) 2011-07-04 2016-02-17 Ｎｅｃソリューションイノベータ株式会社 Method for evaluating redox activity of nucleic acid molecule and nucleic acid molecule having redox activity
EP2751562B1 (en) 2011-09-02 2015-09-16 Nestec S.A. Profiling of signal pathway proteins to determine therapeutic efficacy
US10583128B2 (en) 2011-09-06 2020-03-10 Curna, Inc. Treatment of diseases related to alpha subunits of sodium channels, voltage-gated (SCNxA) with small molecules
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
CN104040337B (en) 2011-09-22 2017-07-14 迈德维特科学有限公司 Screening technique
EP3964285A1 (en) 2011-09-26 2022-03-09 Thermo Fisher Scientific Geneart GmbH High efficiency, small volume nucleic acid synthesis
WO2014153188A2 (en) 2013-03-14 2014-09-25 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
DE102011083555B4 (en) 2011-09-27 2013-10-10 Aspre Ag Analysis method and analyzer
EP2761294B1 (en) 2011-09-29 2019-02-27 Meso Scale Technologies, LLC Biodosimetry panels and methods
PL2768985T3 (en) 2011-10-21 2019-10-31 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
WO2013063519A1 (en) 2011-10-26 2013-05-02 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
WO2013063544A1 (en) 2011-10-27 2013-05-02 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
EP2771103B1 (en) 2011-10-28 2017-08-16 Illumina, Inc. Microarray fabrication system and method
US10100092B2 (en) 2011-11-03 2018-10-16 Vca, Inc. Compositions and methods to detect various infectious organisms
CA2856107C (en) 2011-11-18 2022-10-18 Memorial Sloan-Kettering Cancer Center 2-hydroxyglutarate as a biomarker for chronic hypoxia
WO2013077864A1 (en) 2011-11-22 2013-05-30 Robert Bosch Gmbh Method for self-referenced confidence test
US8748097B1 (en) 2011-12-02 2014-06-10 President And Fellows Of Harvard College Identification of agents for treating calcium disorders and uses thereof
WO2013087789A1 (en) 2011-12-13 2013-06-20 Glykos Finland Ltd. Antibody isoform arrays and methods thereof
WO2013095941A1 (en) 2011-12-19 2013-06-27 Valley Health System Methods and kits for detecting subjects at risk of having cancer
EP2795500B1 (en) 2011-12-20 2020-04-15 Siemens Healthcare Diagnostics Inc. Coated substrates for high energy capture phase binding and methods of production and use thereof
US20130164217A1 (en) 2011-12-21 2013-06-27 Meso Scale Technologies, Llc Method of diagnosing, preventing and/or treating dementia & related disorders
WO2013096661A1 (en) 2011-12-22 2013-06-27 Illumina, Inc. Methylation biomarkers for ovarian cancer
WO2013101771A2 (en) 2011-12-30 2013-07-04 Genentech, Inc. Compositions and method for treating autoimmune diseases
WO2013106790A1 (en) 2012-01-12 2013-07-18 Robert Bosch Gmbh Device and method for indirect electronic condition control in biomolecule detection platforms
AU2013207778B2 (en) 2012-01-13 2017-10-12 Genentech, Inc. Biological markers for identifying patients for treatment with VEGF antagonists
CN104302304A (en) 2012-02-16 2015-01-21 宾西法利亚州研究基金会 Modulators of acyl-coa lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof
EP2827882B1 (en) 2012-02-21 2020-04-08 Cytonics Corporation Systems, compositions, and methods for transplantation
CN104136611B (en) 2012-02-27 2018-03-27 东丽株式会社 The detection method of nucleic acid
US20150031750A1 (en) 2012-03-15 2015-01-29 The Scripps Research Institute Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
JP5999786B2 (en) 2012-03-23 2016-09-28 Ｎｅｃソリューションイノベータ株式会社 ATP or AMP analysis device and analysis method
JP6183917B2 (en) 2012-03-23 2017-08-23 Ｎｅｃソリューションイノベータ株式会社 Streptavidin analysis device and analysis method
CA2867588A1 (en) 2012-03-30 2013-10-03 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
AU2013243300B2 (en) 2012-04-05 2018-12-06 Oregon Health & Science University Gene expression panel for breast cancer prognosis
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
EP2855425A4 (en) 2012-06-04 2016-05-18 Scripps Research Inst Novel phenyl glyoxal probes
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
EP3182126A3 (en) 2012-06-15 2017-08-02 Wayne State University Biomarker test for prediction or early detection of preeclampsia and/or hellp syndrome
EP3339861B8 (en) 2012-06-15 2023-11-01 Genesis Theranostix Korlatolt Felelossegu Tarsasag Biomarker test for prediction or early detection of preeclampsia
US10443085B2 (en) 2012-06-20 2019-10-15 Toray Industries, Inc. Method for detecting nucleic acid and nucleic acid detection kit
EP2870263A1 (en) 2012-07-03 2015-05-13 InteRNA Technologies B.V. Diagnostic portfolio and its uses
US10441636B2 (en) 2012-07-20 2019-10-15 La Trobe University Method of diagnosis and treatment
US20160169875A1 (en) 2012-07-27 2016-06-16 Nec Solution Innovators, Ltd. Nucleic acid sensor for melamine analysis, device for melamine analysis, and method for melamine analysis
JP6320382B2 (en) 2012-08-13 2018-05-09 ザ ロックフェラー ユニヴァーシティ Melanoma treatment and diagnosis
KR102062418B1 (en) 2012-08-31 2020-01-03 도레이 카부시키가이샤 Method for detecting target nucleic acid
US10300450B2 (en) 2012-09-14 2019-05-28 Carterra, Inc. Method and device for depositing a substance on a submerged surface
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
DE102012020496A1 (en) 2012-10-18 2014-04-24 Charité - Universitätsmedizin Berlin Invitro diagnosis and/or early detection of neurofibromatosis type 1 and/or neurofibromatosis type 1-associated tumor from sample of a patient for treating the patient with the tumor, comprises detecting protein or its fragment in sample
CN114177166A (en) 2012-10-31 2022-03-15 洛克菲勒大学 Treatment and diagnosis of colon cancer
JP6334550B2 (en) 2012-11-06 2018-05-30 インベッド バイオサイエンシズ，インコーポレイテッド Methods and compositions for wound healing
RU2660349C2 (en) 2012-11-28 2018-07-05 Мерк Шарп И Доум Корп. Compositions and methods for treatment of malignant tumour
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
EP2759602A1 (en) 2013-01-25 2014-07-30 Charité - Universitätsmedizin Berlin Non-invasive prenatal genetic diagnostic methods
US20140221368A1 (en) 2013-02-01 2014-08-07 Meso Scale Technologies, Llc Biomarkers of therapeutic responsiveness
US20140309263A1 (en) 2013-02-01 2014-10-16 Meso Scale Technologies, Llc Biomarkers of therapeutic responsiveness
AR094873A1 (en) 2013-02-25 2015-09-02 Genentech Inc METHODS AND COMPOSITIONS TO DETECT AND TREAT MUTANTS OF AKT RESISTANT TO DRUGS
US9267171B2 (en) 2013-02-28 2016-02-23 New York University DNA photolithography with cinnamate crosslinkers
WO2014136560A1 (en) 2013-03-08 2014-09-12 Ｎｅｃソリューションイノベータ株式会社 Nucleic acid element candidate molecule and method for screening nucleic acid elements for target analysis using same
EP2971149B1 (en) 2013-03-15 2018-05-09 Baylor Research Institute Ulcerative colitis (uc)-associated colorectal neoplasia markers
EP4163387A1 (en) 2013-03-15 2023-04-12 The University of Chicago Methods and compositions related to t-cell activity
US20140274749A1 (en) 2013-03-15 2014-09-18 Affymetrix, Inc. Systems and Methods for SNP Characterization and Identifying off Target Variants
US9868992B2 (en) 2013-03-15 2018-01-16 Baylor Research Institute Tissue and blood-based miRNA biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
EP3388442A1 (en) 2013-03-15 2018-10-17 Illumina Cambridge Limited Modified nucleosides or nucleotides
CA2908391A1 (en) 2013-05-01 2014-11-06 Five Prime Therapeutics, Inc. Methods of treating cancer
WO2014187308A2 (en) 2013-05-21 2014-11-27 生物梅里埃股份公司 Colorectal cancer prognosis agent kit
MX2015015426A (en) 2013-05-23 2016-06-10 Five Prime Therapeutics Inc Methods of treating cancer.
EP3008229B1 (en) 2013-06-10 2020-05-27 President and Fellows of Harvard College Early developmental genomic assay for characterizing pluripotent stem cell utility and safety
CN105473745B (en) 2013-06-21 2019-12-03 约翰霍普金斯大学 For characterizing the function of people's memebrane protein and the virion display array of interaction
WO2014210225A1 (en) 2013-06-25 2014-12-31 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
ES2700529T3 (en) 2013-07-01 2019-02-18 Illumina Inc Functionalization of surface without catalyst and polymer graft
JP5503062B1 (en) 2013-07-23 2014-05-28 Ｎｅｃソフト株式会社 Fluorescence sensor for target analysis, target analysis kit, and target analysis method using the same
US20150038365A1 (en) 2013-08-01 2015-02-05 Meso Scale Technologies, Llc Lung cancer biomarkers
DK3039424T3 (en) 2013-08-28 2020-08-31 Crown Bioscience Inc Taicang Gene expression signatures predictive of an individual's response to a multikinase inhibitor and methods of using them
CA2922806A1 (en) 2013-08-28 2015-03-05 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions utilizing a composition comprising a wild-type or a variant a2m polypeptide or portion thereof
US10456470B2 (en) 2013-08-30 2019-10-29 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
SG10201802231RA (en) 2013-09-19 2018-05-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
MX2016005159A (en) 2013-10-23 2016-07-05 Genentech Inc Methods of diagnosing and treating eosinophilic disorders.
EP3572875A1 (en) 2013-12-19 2019-11-27 Illumina, Inc. Roll-to-roll process of preparing a patterned substrate and patterned substrate prepared by the same process
CN112322735A (en) 2014-01-16 2021-02-05 启迪公司 Gene expression panels for prognosis of prostate cancer recurrence
WO2015116627A1 (en) 2014-01-29 2015-08-06 Arizona Board Of Regents On Behalf Of Arizona State University Microreactor array platform
PT3099333T (en) 2014-01-31 2020-12-24 Univ Temple Bag3 as a target for therapy of heart failure
US10261084B1 (en) 2014-02-19 2019-04-16 Stc.Unm Activated GTPase-based assays and kits for the diagnosis of sepsis and other infections
JP2017508457A (en) 2014-02-27 2017-03-30 ザ・ブロード・インスティテュート・インコーポレイテッド T cell balance gene expression, composition and method of use thereof
WO2015161148A1 (en) * 2014-04-18 2015-10-22 Ibis Biosciences, Inc. Uniform deposition of material
WO2015175375A1 (en) 2014-05-13 2015-11-19 Short Jay M Conditionally active biological proteins
WO2015187612A1 (en) 2014-06-02 2015-12-10 Valley Health System Method and systems for lung cancer diagnosis
WO2016011052A1 (en) 2014-07-14 2016-01-21 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
EP3183577B1 (en) 2014-08-21 2020-08-19 Illumina Cambridge Limited Reversible surface functionalization
RU2764074C2 (en) 2014-08-28 2022-01-13 Байоатла, Ллк Conditionally active chimeric antigen receptors for modified t-cells
US11111288B2 (en) 2014-08-28 2021-09-07 Bioatla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
US10513699B2 (en) 2014-09-03 2019-12-24 Bioatla, Llc Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts
DK3198035T3 (en) 2014-09-26 2023-01-30 Allarity Therapeutics Europe ApS Methods for predicting drug response
ES2772127T3 (en) 2014-10-31 2020-07-07 Illumina Cambridge Ltd DNA copolymer polymers and coatings
US11708608B2 (en) 2014-11-10 2023-07-25 Genentech, Inc. Therapeutic and diagnostic methods for IL-33-mediated disorders
US10683552B2 (en) 2014-11-25 2020-06-16 Presidents And Fellows Of Harvard College Clonal haematopoiesis
EP3626832A3 (en) 2014-11-25 2020-05-13 The Brigham and Women's Hospital, Inc. Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
SG10202012249YA (en) 2014-12-08 2021-01-28 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
CA3147259A1 (en) 2014-12-09 2016-06-16 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
EP3237906B8 (en) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
CN107223163A (en) 2014-12-24 2017-09-29 豪夫迈·罗氏有限公司 For the treatment of bladder cancer, diagnosis and method of prognosis
EP3056904A1 (en) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-MCM3
EP3056903A1 (en) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-Casp8
CN107484423A (en) 2015-02-13 2017-12-15 豪夫迈·罗氏有限公司 The method of rheumatoid arthritis is assessed by measuring anti-CCP and anti-PIK3CD
US11434264B2 (en) 2015-02-13 2022-09-06 Quanterix Corporation Immunoassays for differential detection of clostridium difficile
AU2016222830B2 (en) 2015-02-24 2021-02-25 Bioatla Llc Conditionally active biological proteins
NZ734644A (en) 2015-02-24 2023-02-24 Hope City Chemically encoded spatially addressed library screening platforms
EP3262193A2 (en) 2015-02-26 2018-01-03 The Broad Institute Inc. T cell balance gene expression, compositions of matters and methods of use thereof
CN104826673B (en) * 2015-03-16 2017-06-23 中国科学院微生物研究所 Write two dimension Microfluidic droplet array device, purposes and its application method
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
WO2016164641A1 (en) 2015-04-08 2016-10-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
EP3530752B1 (en) 2015-04-10 2021-03-24 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
WO2016176726A1 (en) 2015-05-01 2016-11-10 Griffith University Diagnostic methods
WO2016196065A1 (en) 2015-05-29 2016-12-08 Genentech, Inc. Methods and compositions for assessing responsiveness of cancers to bet inhibitors
WO2016195982A2 (en) 2015-06-01 2016-12-08 The Penn State Research Foundation Hepatitis b virus capsid assembly
CN107835857A (en) 2015-07-17 2018-03-23 亿明达股份有限公司 For the polymer sheet layer of application to be sequenced
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
EP3859333A1 (en) 2015-09-10 2021-08-04 InSilixa, Inc. Systems for multiplex quantitative nucleic acid amplification
EP3141613A1 (en) 2015-09-11 2017-03-15 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Detection of quality of surface water
WO2017053838A1 (en) 2015-09-23 2017-03-30 Oklahoma Medical Research Foundation Biomarkers for assessing subjects with multiple sclerosis
TW201723190A (en) 2015-10-22 2017-07-01 永斯醫療股份有限公司 Gene signatures for determining ICOS expression
CA3007462C (en) 2015-12-07 2023-10-24 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US9845499B2 (en) * 2016-04-04 2017-12-19 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
US11285478B2 (en) 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
RS63698B1 (en) 2016-05-13 2022-11-30 Bioatla Inc Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof
CN109313396B (en) 2016-05-18 2022-11-22 Illumina公司 Self-assembly patterning using patterned hydrophobic surfaces
US20190256915A1 (en) 2016-09-14 2019-08-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Methods of diagnosing and treating cd55 deficiency, hyperactivation of complement, angiopathic thrombosis and protein losing enteropathy (chaple), a newly identified orphan disease
TW201815766A (en) 2016-09-22 2018-05-01 美商普雷辛肯公司 Compounds and methods for IDO and TDO modulation, and indications therefor
JP2020510608A (en) 2016-11-02 2020-04-09 デビオファーム インターナショナル， エス． アー． Method for improving anti-CD37 immunoconjugate therapy
CA3042724A1 (en) 2016-11-17 2018-05-24 Combinati Incorporated Methods and systems for nucleic acid analysis and quantification
CA3047580A1 (en) 2016-12-23 2018-07-26 Plexxikon Inc. Compounds and methods for cdk8 modulation and indications therefor
US11771703B2 (en) 2017-03-17 2023-10-03 The Johns Hopkins University Targeted epigenetic therapy against distal regulatory element of TGFβ2 expression
CN110520543A (en) 2017-03-29 2019-11-29 中美冠科生物技术（太仓）有限公司 Determine gastric cancer to the system and method for Cetuximab sensibility
WO2018187191A1 (en) 2017-04-03 2018-10-11 Jounce Therapeutics, Inc Compositions and methods for the treatment of cancer
EP3615694B1 (en) 2017-04-25 2022-03-30 The Brigham and Women's Hospital, Inc. Il-8, il-6, il-1b and tet2 and dnmt3a in atherosclerosis
WO2018209398A1 (en) 2017-05-17 2018-11-22 Microbio Pty Ltd Biomarkers and uses thereof
WO2018213729A1 (en) * 2017-05-19 2018-11-22 Tidhar Shalon Devices and methods for collecting gastrointestinal samples
US10428067B2 (en) 2017-06-07 2019-10-01 Plexxikon Inc. Compounds and methods for kinase modulation
US11679384B2 (en) 2017-07-21 2023-06-20 Germitec Bioassay carrier and preparation thereof
ES2947336T3 (en) 2017-09-01 2023-08-07 Univ Johns Hopkins Targeted epigenetic therapy for hereditary aortic aneurysm
WO2019060607A1 (en) 2017-09-20 2019-03-28 Quanterix Corporation Methods and systems for the detection of analyte molecules
CA3079524A1 (en) 2017-11-03 2019-05-09 Interna Technologies B.V. Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
WO2019104062A1 (en) 2017-11-21 2019-05-31 Rgenix, Inc. Polymorphs and uses thereof
US11801506B2 (en) * 2018-01-30 2023-10-31 Hewlett-Packard Development Company, L.P. Fluid ejections in nanowells
JP7418337B2 (en) 2018-02-09 2024-01-19 ジェネンテック， インコーポレイテッド Treatment and diagnosis of mast cell-mediated inflammatory diseases
WO2019173703A1 (en) 2018-03-08 2019-09-12 Meso Scale Technologies, Llc. Genetic marker and/or biomarkers for traumatic brain injury, and ultrasensitive assays for biomarkers of traumatic brain injury
US20210317524A1 (en) 2018-08-28 2021-10-14 10X Genomics, Inc. Resolving spatial arrays
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
SG11202102029TA (en) 2018-08-28 2021-03-30 10X Genomics Inc Methods for generating spatially barcoded arrays
CA3112792A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
WO2020067121A1 (en) 2018-09-25 2020-04-02 東レ株式会社 Alkaline phosphatase composition, method for producing dephosphorylated nucleic acid and method for producing labeled nucleic acid
WO2020067122A1 (en) 2018-09-25 2020-04-02 東レ株式会社 Alkaline phosphatase composition and production methods for dephosphorylated nucleic acid and labelled nucleic acid
CN112955566A (en) 2018-09-25 2021-06-11 东丽株式会社 Method for evaluating quality of dephosphorylation reagent and method for detecting target nucleic acid
US11884980B2 (en) 2018-11-28 2024-01-30 Bioscreening & Diagnostics Llc Method for detection of traumatic brain injury
KR20210108970A (en) 2018-12-07 2021-09-03 엘리먼트 바이오사이언스, 인크. Flow cell devices and uses thereof
EP3894587A1 (en) 2018-12-10 2021-10-20 10X Genomics, Inc. Resolving spatial arrays by proximity-based deconvolution
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
EP3931354A1 (en) 2019-02-28 2022-01-05 10X Genomics, Inc. Profiling of biological analytes with spatially barcoded oligonucleotide arrays
JP2022525322A (en) 2019-03-14 2022-05-12 インシリクサ， インコーポレイテッド Methods and systems for time-gate fluorescence-based detection
EP3938538A1 (en) 2019-03-15 2022-01-19 10X Genomics, Inc. Methods for using spatial arrays for single cell sequencing
WO2020198071A1 (en) 2019-03-22 2020-10-01 10X Genomics, Inc. Three-dimensional spatial analysis
AU2020247911A1 (en) 2019-03-26 2021-11-11 Dermtech, Inc. Novel gene classifiers and uses thereof in skin cancers
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
JP2022526844A (en) 2019-04-12 2022-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Compositions and Methods for Increasing Muscle Mass and Oxidative Metabolism
KR20220015394A (en) 2019-04-30 2022-02-08 라리마 테라퓨틱스, 인코포레이티드 Frataxin sensitivity markers for determining the efficacy of prataxin replacement therapy
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
EP4038546A1 (en) 2019-10-01 2022-08-10 10X Genomics, Inc. Systems and methods for identifying morphological patterns in tissue samples
US20220397579A1 (en) 2019-11-05 2022-12-15 Meso Scale Technologies, Llc. Methods and kits for quantitating radiation exposure
EP4025711A2 (en) 2019-11-08 2022-07-13 10X Genomics, Inc. Enhancing specificity of analyte binding
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
US20230002812A1 (en) 2019-11-13 2023-01-05 10X Genomics, Inc. Generating capture probes for spatial analysis
CN115004260A (en) 2019-11-18 2022-09-02 10X基因组学有限公司 System and method for tissue classification
US20210155982A1 (en) 2019-11-21 2021-05-27 10X Genomics, Inc. Pipeline for spatial analysis of analytes
CA3158891A1 (en) 2019-11-22 2021-05-27 Neil Ira WEISENFELD Systems and methods for spatial analysis of analytes using fiducial alignment
US20230021837A1 (en) 2019-11-26 2023-01-26 Meso Scale Technologies, Llc. Methods and kits for detecting autoimmune diseases
CA3161274A1 (en) 2019-12-13 2021-06-17 Stephen Wald Metal salts and uses thereof
EP3891300B1 (en) 2019-12-23 2023-03-29 10X Genomics, Inc. Methods for spatial analysis using rna-templated ligation
EP4090771A1 (en) 2020-01-13 2022-11-23 Jounce Therapeutics, Inc. Methods for the treatment of cancer
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
AU2021225020A1 (en) 2020-02-21 2022-08-18 10X Genomics, Inc. Methods and compositions for integrated in situ spatial assay
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
CA3172579A1 (en) 2020-04-15 2021-10-21 David C. Duffy Methods and systems related to highly sensitive assays and by deliveringcapture objects
WO2021216708A1 (en) 2020-04-22 2021-10-28 10X Genomics, Inc. Methods for spatial analysis using targeted rna depletion
US20230184768A1 (en) 2020-05-01 2023-06-15 Meso Scale Technologies, Llc. Viral serology ace2 competition assays
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
WO2021247568A1 (en) 2020-06-02 2021-12-09 10X Genomics, Inc. Spatial trancriptomics for antigen-receptors
AU2021283174A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Nucleic acid library methods
EP4162074B1 (en) 2020-06-08 2024-04-24 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
CN115867560A (en) 2020-06-22 2023-03-28 伊鲁米纳剑桥有限公司 Nucleosides and nucleotides having 3' acetal capping groups
CN116034166A (en) 2020-06-25 2023-04-28 10X基因组学有限公司 Spatial analysis of DNA methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US20220033900A1 (en) 2020-07-28 2022-02-03 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
WO2022147134A1 (en) 2020-12-30 2022-07-07 10X Genomics, Inc. Molecular arrays and methods for generating and using the arrays
US20220314187A1 (en) 2020-12-30 2022-10-06 10X Genomics, Inc. Methods and compositions for light-controlled surface patterning using a polymer
WO2022147140A1 (en) 2020-12-30 2022-07-07 10X Genomics, Inc. Molecular array generation using photoresist
EP4301870A1 (en) 2021-03-18 2024-01-10 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
CA3214833A1 (en) 2021-04-06 2022-10-13 Bpgbio, Inc. Protein markers for the prognosis of breast cancer progression
US20230059578A1 (en) 2021-04-06 2023-02-23 Berg Llc Protein markers for estrogen receptor (er)-positive-like and estrogen receptor (er)-negative-like breast cancer
EP4320440A1 (en) 2021-04-06 2024-02-14 BPGbio, Inc. Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer
AU2022269804A1 (en) 2021-05-05 2023-11-02 Illumina Cambridge Limited Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing
US20220396832A1 (en) 2021-05-20 2022-12-15 Illumina Cambridge Limited Compositions and methods for sequencing by synthesis
WO2022246215A1 (en) 2021-05-21 2022-11-24 Meso Scale Technologies, Llc. Viral strain serology assays
CN117677435A (en) 2021-06-15 2024-03-08 伊鲁米纳公司 Surface functionalization of non-aqueous gels for sequencing
CN117813391A (en) 2021-07-23 2024-04-02 因美纳有限公司 Method for preparing substrate surface for DNA sequencing
EP4196605A1 (en) 2021-09-01 2023-06-21 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2023069927A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
US11820140B2 (en) 2022-03-21 2023-11-21 Funai Electric Co., Ltd Dispense modes for multi-mode capable device
CA3222807A1 (en) 2022-03-22 2023-09-28 Alexandra SZEMJONOV Substrate with orthogonally functional nanodomains
CA3223115A1 (en) 2022-03-28 2023-10-05 Xiaolin Wu Labeled avidin and methods for sequencing
US20230314322A1 (en) 2022-03-29 2023-10-05 Illumina, Inc. Systems and methods of sequencing polynucleotides
US20230357851A1 (en) 2022-04-06 2023-11-09 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin-replacement therapy
WO2023194369A1 (en) 2022-04-08 2023-10-12 Fundació Institut Mar D'investigacions Mèdiques (Imim) Genetic markers for severe covid-19
US20230383342A1 (en) 2022-05-31 2023-11-30 Illumina Cambridge Limited Compositions and methods for nucleic acid sequencing
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
WO2023245184A1 (en) 2022-06-17 2023-12-21 Meso Scale Technologies, Llc. Viral strain serology assays
US20230416279A1 (en) 2022-06-28 2023-12-28 Illumina Cambridge Limited Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
WO2024006830A1 (en) 2022-06-29 2024-01-04 10X Genomics, Inc. Methods and compositions for patterned molecular array generation by directed bead delivery
WO2024006799A1 (en) 2022-06-29 2024-01-04 10X Genomics, Inc. Covalent attachment of splint oligonucleotides for molecular array generation using ligation
US20240117338A1 (en) 2022-06-29 2024-04-11 10X Genomics, Inc. Methods and compositions for refining feature boundaries in molecular arrays
US20240026444A1 (en) 2022-06-29 2024-01-25 10X Genomics, Inc. Compositions and methods for generating molecular arrays using oligonucleotide printing and photolithography
US20240002932A1 (en) 2022-06-29 2024-01-04 10X Genomics, Inc. Click chemistry-based dna photo-ligation for manufacturing of high-resolution dna arrays
US20240060127A1 (en) 2022-06-29 2024-02-22 10X Genomics, Inc. Methods and systems for light-controlled surface patterning using photomasks
US20240076722A1 (en) 2022-06-29 2024-03-07 10X Genomics, Inc. Compositions and methods for oligonucleotide inversion on arrays
US20240076721A1 (en) 2022-06-29 2024-03-07 10X Genomics, Inc. Method of generating arrays using microfluidics and photolithography
WO2024006798A1 (en) 2022-06-29 2024-01-04 10X Genomics, Inc. High definition molecular array feature generation using photoresist
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders
WO2024039516A1 (en) 2022-08-19 2024-02-22 Illumina, Inc. Third dna base pair site-specific dna detection
US20240103002A1 (en) 2022-09-23 2024-03-28 Meso Scale Technologies, Llc. Orthopoxvirus serology assays
WO2024068889A2 (en) 2022-09-30 2024-04-04 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3730844A (en) * 1971-08-27 1973-05-01 Purdue Research Foundation Polynucleotide analysis
FR2353856A1 (en) * 1976-06-02 1977-12-30 Chateau Guy TAPE INTENDED TO BE USED AS A SUPPORT FOR A REACTION FOR EXAMPLE CHEMICAL OR BIOCHEMICAL, AND ANALYSIS PROCESS IMPLEMENTING IT
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
FI63596C (en) * 1981-10-16 1983-07-11 Orion Yhtymae Oy MICROBIA DIAGNOSIS FOERFARANDE SOM GRUNDAR SIG PAO SKIKTSHYBRIDISERING AV NUCLEINSYROR OCH VID FOERFARANDET ANVAENDA KOMBINATIONER AV REAGENSER
US4556643A (en) * 1982-07-26 1985-12-03 Agracetus Assay method and probe for polynucleotide sequences
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US4677054A (en) * 1983-08-08 1987-06-30 Sloan-Kettering Institute For Cancer Research Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization
FI71768C (en) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Enhanced nucleic acid reagents and process for their preparation.
GB8405437D0 (en) * 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
US4670380A (en) * 1984-05-23 1987-06-02 Molecular Diagnostics, Inc. Assays utilizing labeled nucleic acid probes
US4755458A (en) * 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US5064754A (en) * 1984-12-14 1991-11-12 Mills Randell L Genomic sequencing method
US4767700A (en) * 1985-02-15 1988-08-30 Beckman Research Institute Of The City Of Hope Detection of particular nucleotide sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4868104A (en) * 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US5348855A (en) * 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
US4981783A (en) * 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5100777A (en) * 1987-04-27 1992-03-31 Tanox Biosystems, Inc. Antibody matrix device and method for evaluating immune status
SE458968B (en) * 1987-06-16 1989-05-22 Wallac Oy BIOSPECIFIC ANALYTICAL PROCEDURE FOR MULTIPLE ANALYTICS WHICH DO NOT INCLUDE PARTICULAR COATING AND LABELING WITH FLUORESCING LABEL SUBSTANCES
US4921805A (en) * 1987-07-29 1990-05-01 Life Technologies, Inc. Nucleic acid capture method
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5013669A (en) * 1988-06-01 1991-05-07 Smithkline Diagnostics, Inc. Mass producible biologically active solid phase devices
US5204268A (en) * 1988-06-02 1993-04-20 Fuji Photo Film Co., Ltd. Method and apparatus for applying liquid samples
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5389512A (en) * 1988-10-07 1995-02-14 Hoffman-La Roche Inc. Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5200312A (en) * 1989-01-30 1993-04-06 The United States Of America As Represented By The Secretary Of The Navy Membrane based dot immunoassay and method of use
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5242974A (en) * 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
DK0455905T3 (en) * 1990-05-11 1998-12-07 Microprobe Corp Dipsticks for nucleic acid hybridization assays and method for covalent immobilization of oligonucleotides
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
DE4024545A1 (en) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Metered delivery of biochemical analytical soln., esp. reagent
US5474895A (en) * 1990-11-14 1995-12-12 Siska Diagnostics Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
EP0834576B1 (en) * 1990-12-06 2002-01-16 Affymetrix, Inc. (a Delaware Corporation) Detection of nucleic acid sequences
WO1992022680A1 (en) * 1991-06-17 1992-12-23 Stauffer John E Improved process for removal of sulfur dioxide from waste gases
US5556748A (en) * 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5326691A (en) * 1991-11-21 1994-07-05 John Hozier Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
CA2124087C (en) * 1991-11-22 2002-10-01 James L. Winkler Combinatorial strategies for polymer synthesis
JPH05236997A (en) * 1992-02-28 1993-09-17 Hitachi Ltd Chip for catching polynucleotide
DE69330750T2 (en) * 1992-03-04 2002-07-04 Univ California COMPARATIVE GENOM HYBRIDIZATION
WO1993020236A1 (en) * 1992-04-03 1993-10-14 Applied Biosystems, Inc. Probe composition and method
EP0606422B1 (en) * 1992-07-02 1997-09-03 SOINI, Erkki Biospecific multiparameter assay method
DE69431719T2 (en) * 1993-06-25 2003-09-18 Affymetrix Inc N D Ges D Staat HYBRIDIZATION AND SEQUENCING OF NUCLEIC ACIDS
US5512430A (en) * 1993-07-13 1996-04-30 Hri Research, Inc. Diagnostic array for virus infection
US5472842A (en) * 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
EP0730663B1 (en) * 1993-10-26 2003-09-24 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5610287A (en) * 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US5578832A (en) * 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
EP0743989B1 (en) * 1994-02-14 2007-03-21 Smithkline Beecham Corporation Methed of identifying differentially expressed genes
US6015880A (en) * 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5795716A (en) * 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays

Also Published As

Publication number Publication date
EP0804731B1 (en) 1999-05-26
EP0804731B2 (en) 2012-05-09
CA2192095A1 (en) 1995-12-28
EP0804731A4 (en) 1997-11-26
JP3272365B2 (en) 2002-04-08
ES2134481T5 (en) 2012-06-25
AU2862995A (en) 1996-01-15
US6110426A (en) 2000-08-29
DE69509925D1 (en) 1999-07-01
ES2134481T3 (en) 1999-10-01
ATE180570T1 (en) 1999-06-15
DE69509925T2 (en) 1999-12-09
WO1995035505A1 (en) 1995-12-28
EP0804731A1 (en) 1997-11-05
CA2192005C (en) 2005-10-25
GR3030430T3 (en) 1999-09-30
DE69509925T3 (en) 2012-07-19
EP0913485A1 (en) 1999-05-06
AU709276B2 (en) 1999-08-26
CA2192095C (en) 1999-08-31
DK0804731T3 (en) 1999-11-08
JP2002243736A (en) 2002-08-28
DK0804731T4 (en) 2012-07-09
JPH10503841A (en) 1998-04-07
US5807522A (en) 1998-09-15

Similar Documents

Publication Publication Date Title
CA2192005A1 (en) Rolling door made from interlocking thermoplastic panels
USD400429S (en) Magnetic fastener
CA2242240A1 (en) Interlocked restraint for a plastic pipe joining system
CA2316552A1 (en) Gangable electrical box
GB2244181B (en) Double lock male/female type connector
CA2047666A1 (en) Extruded node
USD360267S (en) Door jamb
CA2180054A1 (en) Curved Wall Trailer Construction
EP0657961A3 (en) Male terminal fitting and method of producing the same.
AU3473893A (en) One-piece fitment and tethered plug with tamper-evident means
EP0726617A3 (en) Connector with secondary locking and coupling mechanism
CA2075648A1 (en) Pipe swivel joint with improved bore seal
USD402357S (en) Hose coupling with water stop
USD419522S (en) Four position two-piece battery block connector assembly
USD358295S (en) Valve coupling
CA2236077A1 (en) An animal ear tag
USD330432S (en) Extrusion for use with doors formed from spaced panels
EP0606544A3 (en) Intermediate member for a torque transmitting coupling and method of manufacturing the same.
USD423918S (en) Joint for pipe structure
MY132605A (en) Separable bumper structural body
USD376213S (en) Door jamb
USD418398S (en) Joint for pipe structure
USD345764S (en) Mannequin
USD368697S (en) Coaxial cable connector
USD384329S (en) Flexible jumper

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed