CA2185616A1 - Hormonal agent for skin treatment - Google Patents
Hormonal agent for skin treatmentInfo
- Publication number
- CA2185616A1 CA2185616A1 CA002185616A CA2185616A CA2185616A1 CA 2185616 A1 CA2185616 A1 CA 2185616A1 CA 002185616 A CA002185616 A CA 002185616A CA 2185616 A CA2185616 A CA 2185616A CA 2185616 A1 CA2185616 A1 CA 2185616A1
- Authority
- CA
- Canada
- Prior art keywords
- dienogest
- skin
- androstandiol
- glucuronide
- moderate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Abstract
The pharmaceutical composition, especially for treating skin with seborrhea, Acne vulgaris and androgonically conditioned alopecia, contains a hormonal agent including the gestogen, dienogest, or a combination of dienogest and an estrogen, as active ingredient. Methods for treatment of this type of skin condition include topical application of the composition including the dienogest which results in an outstanding sebosuppression, a drastic reduction of androstandiol glucuronide and a moderate competitive blockage of androgen receptor sites. Galenic formulations are described which limit and/or prevent the permeation of the active ingredient through the skin. The pharmaceutical preparation including the dienogest and conventional dermatologically acceptable carrier and auxiliary substances in the described galenic formulation advantageously provides a drastic reduction in androstandiol glucuronide and moderate androgen receptor blockage without passing through the skin barrier so that systemic effects including side reactions are substantially prevented.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19534209A DE19534209A1 (en) | 1995-09-15 | 1995-09-15 | Hormonal agent for the treatment of the skin |
DE19534209.7 | 1995-09-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2185616A1 true CA2185616A1 (en) | 1997-03-17 |
CA2185616C CA2185616C (en) | 2001-02-27 |
Family
ID=7772237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002185616A Expired - Fee Related CA2185616C (en) | 1995-09-15 | 1996-09-16 | Hormonal agent for skin treatment |
Country Status (4)
Country | Link |
---|---|
US (1) | US5910493A (en) |
EP (1) | EP0765663A3 (en) |
CA (1) | CA2185616C (en) |
DE (1) | DE19534209A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6488940B2 (en) | 1997-08-21 | 2002-12-03 | Johnson & Johnson Consumer Companies, Inc. | Use of 17-α-estradiol for the treatment of aged or sundamaged skin and/or skin atrophy |
BR9811963A (en) * | 1997-08-21 | 2002-02-05 | Johson & Johnson Consumer Comp | Use of 17-alpha-estradiol for the treatment of aged or sun-damaged skin and / or skin atrophy |
WO2000018362A1 (en) * | 1998-09-28 | 2000-04-06 | Petersen, Sharleen, Caron | Hair growth stimulant |
DE19916384A1 (en) * | 1999-03-31 | 2000-10-05 | Schering Ag | Microparticles useful in treatment of androgen-dependent disorders include biodegradable, synthetic polymers of e.g. polyesters of hydroxycarboxylic acids |
WO2000062753A1 (en) * | 1999-04-16 | 2000-10-26 | Jenapharm Gmbh & Co. Kg | Pharmaceutical or cosmetic compositions for the local, intradermal application of hormones |
DE19918644A1 (en) * | 1999-04-16 | 2000-10-26 | Jenapharm Gmbh | Intradermal composition for local treatment of skin aging or wrinkles, comprising matrix containing estrogen and structure former to minimize systemic side-effects |
DE10141443B4 (en) * | 2001-08-23 | 2007-02-01 | Christos C. Prof. Dr. Zouboulis | Use of molecular biologically produced, non-viral agents for the treatment of acne |
ATE419037T1 (en) * | 2002-09-04 | 2009-01-15 | Fraunhofer Ges Forschung | USE OF AN AGENT FOR THE THERAPY OF CARDIAC HYPERTROPHY |
AU2005214167B2 (en) * | 2004-02-13 | 2008-08-07 | Warner-Lambert Company Llc | Androgen receptor modulators |
CA2563291A1 (en) * | 2004-04-13 | 2005-10-27 | Warner-Lambert Company Llc | 4-cyano-phenoxy-alkyl carboxyl derivatives as androgen modulators |
CA2562672C (en) * | 2004-04-22 | 2009-09-29 | Warner-Lambert Company Llc | 4-cyano-phenoxy derivatives as androgen modulators |
BRPI0513020A (en) * | 2004-07-08 | 2008-04-22 | Warner Lambert Co | androgen modulators, their uses, pharmaceutical composition, topical pharmaceutical formulation and article of manufacture |
US20080064745A1 (en) * | 2004-08-18 | 2008-03-13 | Warner-Lambert Company Llc | Androgen Modulators |
US20060118002A1 (en) * | 2004-12-03 | 2006-06-08 | Sud-Chemie Inc. | Organoclay composition containing quat mixtures |
TW200724139A (en) * | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
US20090170886A1 (en) * | 2005-08-08 | 2009-07-02 | Pfizer Inc | Androgen modulators |
US8288366B2 (en) | 2006-06-20 | 2012-10-16 | Chochinov Ronald H | Formulation for hair growth |
DE102006062120A1 (en) | 2006-12-22 | 2008-06-26 | Grünenthal GmbH | Pharmaceutical composition for acne treatment |
US8846063B2 (en) * | 2008-12-16 | 2014-09-30 | Kimberly-Clark Worldwide, Inc. | Personal care composition containing a volatile and a terpene alcohol |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2257223A1 (en) * | 1972-11-22 | 1974-06-12 | Fouad Dr Med Talabani | Hair growth and anti- hairloss compsn. - contg. mixts of androgen, oestrogen, corticoid and carriers |
DE4229820C2 (en) * | 1992-09-07 | 1998-12-03 | Jenapharm Gmbh | Progestogen-based pharmaceutical preparation |
DE4308406C1 (en) * | 1993-03-12 | 1994-06-16 | Jenapharm Gmbh | Contraceptive compsn. with reduced hormone dose and reduced side-effects - contg. synergistic mixt. of biogenic, synthetic oestrogen and gestagen |
DE4313926A1 (en) * | 1993-04-28 | 1994-11-03 | Jenapharm Gmbh | Multiphase pharmaceutical product for hormonal contraception |
DE4321957C2 (en) * | 1993-07-01 | 1995-09-28 | Marika Dr Med Ehrlich | Use of a hormonal agent to treat acne |
DE4406462C2 (en) * | 1994-02-24 | 1997-05-28 | Jenapharm Gmbh | Process and apparatus for the preparation of solid dispersions |
-
1995
- 1995-09-15 DE DE19534209A patent/DE19534209A1/en not_active Withdrawn
-
1996
- 1996-09-12 EP EP96114619A patent/EP0765663A3/en not_active Withdrawn
- 1996-09-16 CA CA002185616A patent/CA2185616C/en not_active Expired - Fee Related
- 1996-09-16 US US08/714,463 patent/US5910493A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE19534209A1 (en) | 1997-03-20 |
CA2185616C (en) | 2001-02-27 |
EP0765663A3 (en) | 1997-11-12 |
US5910493A (en) | 1999-06-08 |
EP0765663A2 (en) | 1997-04-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |