CA2185470A1 - Compositions and methods for vaccines comprising .alpha.-galactosyl epitopes - Google Patents
Compositions and methods for vaccines comprising .alpha.-galactosyl epitopesInfo
- Publication number
- CA2185470A1 CA2185470A1 CA002185470A CA2185470A CA2185470A1 CA 2185470 A1 CA2185470 A1 CA 2185470A1 CA 002185470 A CA002185470 A CA 002185470A CA 2185470 A CA2185470 A CA 2185470A CA 2185470 A1 CA2185470 A1 CA 2185470A1
- Authority
- CA
- Canada
- Prior art keywords
- alpha
- compositions
- methods
- vaccines
- galactosyl epitopes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- FHIVAFMUCKRCQO-UHFFFAOYSA-N diazinon Chemical compound CCOP(=S)(OCC)OC1=CC(C)=NC(C(C)C)=N1 FHIVAFMUCKRCQO-UHFFFAOYSA-N 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/193—Equine encephalomyelitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/816—Viral vaccine for avian species, e.g. poultry or other birds
Abstract
The invention encompasses methods and compositions for inducing an immune response in an anti-Gal synthesizing animal including viral and tumor antigens manipulated to express .alpha.-galactosyl epitopes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21320094A | 1994-03-15 | 1994-03-15 | |
US08/213,200 | 1994-03-15 | ||
PCT/US1995/003156 WO1995024924A1 (en) | 1994-03-15 | 1995-03-13 | COMPOSITIONS AND METHODS FOR VACCINES COMPRISING α-GALACTOSYL EPITOPES |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2185470A1 true CA2185470A1 (en) | 1995-09-21 |
CA2185470C CA2185470C (en) | 2005-10-25 |
Family
ID=22794122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002185470A Expired - Lifetime CA2185470C (en) | 1994-03-15 | 1995-03-13 | Compositions and methods for vaccines comprising .alpha.-galactosyl epitopes |
Country Status (6)
Country | Link |
---|---|
US (2) | US5879675A (en) |
EP (1) | EP0754057B1 (en) |
AU (1) | AU2158995A (en) |
CA (1) | CA2185470C (en) |
DE (1) | DE69517683T2 (en) |
WO (1) | WO1995024924A1 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5879675A (en) * | 1994-03-15 | 1999-03-09 | Medical College Of Pennsylvania And Hahnemann University | Compositions and methods for vaccines comprising α-galactosyl epitopes |
AU716818B2 (en) * | 1995-10-24 | 2000-03-09 | Sangstat Medical Corporation | Anti alpha-galactosyl screening technique |
DE19626614A1 (en) * | 1996-07-02 | 1998-01-08 | Immuno Ag | Complex of antigen and cell component, vaccine composition containing the complex, pharmaceutical preparation and process for the preparation of the complex |
US5869035A (en) * | 1996-11-13 | 1999-02-09 | Human Gene Therapy Research Institute | Methods and compositions for inducing complement destruction of tissue |
ATE427966T1 (en) * | 1997-02-11 | 2009-04-15 | Immunomedics Inc | STIMULATION OF AN IMMUNE RESPONSE THROUGH ANTIBODIES LABELED WITH THE ALPHA-GALACTOSYLE PITOPOPE |
CA2326618A1 (en) * | 1998-04-15 | 1999-10-21 | Baxter International Inc. | Inhibition of xenoreactive antibodies |
US6613330B1 (en) | 1998-08-11 | 2003-09-02 | Rush University | Methods and compositions for preventing anti-Gal production in xenograft recipients |
US7005126B1 (en) * | 1999-06-08 | 2006-02-28 | Human Gene Therapy Research Institute | Method for tumor treatment using infusion of xenogeneic cells to induce hyperacute rejection and innocent bystander effect |
US6818395B1 (en) * | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
WO2003020039A1 (en) * | 2001-08-28 | 2003-03-13 | Rush-Presbyterian-St. Luke's Medical Center | Immune tolerance to predetermined antigens |
WO2003088995A2 (en) * | 2002-04-22 | 2003-10-30 | Recopharma Ab | Mucin fusion polypeptide vaccines, compositions and methods of use thereof |
US20050201993A1 (en) * | 2002-10-09 | 2005-09-15 | Link Charles J.Jr. | Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase |
ES2341335T3 (en) * | 2002-10-09 | 2010-06-18 | Central Iowa Health System | ANTI-TURMOR VACCINE USING ALLOGENIC TUMOR CELLS CODIFYING ALPHA (1,3) -GROACTOSIL TRNSFERSA. |
WO2004069873A2 (en) * | 2003-02-06 | 2004-08-19 | Tripep Ab | Antigen/antibody or ligand/receptor glycosylated specificity exchangers |
US7820628B2 (en) * | 2005-02-22 | 2010-10-26 | University Of Massachusetts Medical School | Tumor lesion regression and conversion in situ into autologous tumor vaccines by compositions that result in anti-Gal antibody binding |
US7998486B2 (en) | 2006-10-25 | 2011-08-16 | Newlink Genetics Corporation | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes |
EP2134361A4 (en) | 2007-03-26 | 2010-09-22 | Univ Massachusetts Medical | Compositions and methods for increasing immunogenicity of glycoprotein vaccines |
US8865178B2 (en) | 2007-07-17 | 2014-10-21 | University Of Massachusetts | Compositions and methods for wound healing |
US8084057B2 (en) * | 2007-07-17 | 2011-12-27 | University Of Massachusetts | Compositions and methods for wound healing |
US20090123494A1 (en) * | 2007-07-31 | 2009-05-14 | William Staplin | Momlv-based pseudovirion packaging cell line |
AU2009251328B2 (en) | 2008-05-30 | 2014-10-02 | Glycofi, Inc. | Yeast strain for the production of proteins with terminal alpha-1,3-linked galactose |
EP2499245B1 (en) * | 2009-11-11 | 2016-09-14 | Momenta Pharmaceuticals, Inc. | Glycosyl transferase from chinese hamster and related methods |
WO2012135313A1 (en) * | 2011-03-28 | 2012-10-04 | University Of Massachusetts | Compositions and methods for detecting allergy to a-gal epitopes |
US9861702B2 (en) | 2012-10-22 | 2018-01-09 | Wisconsin Alumni Research Foundation | Lipid-conjugated rhamnose for immune system recruitment and oncotherapy |
US10092586B2 (en) | 2014-05-09 | 2018-10-09 | Agalimmune Limited | Glycolipid containing compositions for use in the treatment of tumors |
US11471420B2 (en) * | 2017-04-21 | 2022-10-18 | Coastar Therapeutics Inc. | Membrane lipid coated nanoparticles and method of use |
EP3612169A4 (en) * | 2017-04-21 | 2020-09-09 | Coastar Therapeutics Inc. | Membrane lipid coated nanoparticles and method of use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4008317A (en) * | 1975-12-29 | 1977-02-15 | Recherche Et Industrie Therapeutiques (R.I.T.) | Varicella-zoster virus vaccine and preparation thereof |
US5879675A (en) * | 1994-03-15 | 1999-03-09 | Medical College Of Pennsylvania And Hahnemann University | Compositions and methods for vaccines comprising α-galactosyl epitopes |
US5871997A (en) * | 1994-07-21 | 1999-02-16 | Alexion Pharmaceuticals, Inc. | Methods and compositions for protecting retroviral vector particles and producer cells from inactivation by complement via reduction of the expression or recognition of galactose alpha (1,3) galactosyl epitopes |
-
1995
- 1995-03-13 US US08/704,548 patent/US5879675A/en not_active Expired - Lifetime
- 1995-03-13 CA CA002185470A patent/CA2185470C/en not_active Expired - Lifetime
- 1995-03-13 DE DE69517683T patent/DE69517683T2/en not_active Expired - Lifetime
- 1995-03-13 EP EP95914710A patent/EP0754057B1/en not_active Expired - Lifetime
- 1995-03-13 WO PCT/US1995/003156 patent/WO1995024924A1/en active IP Right Grant
- 1995-03-13 AU AU21589/95A patent/AU2158995A/en not_active Abandoned
-
1998
- 1998-10-15 US US09/173,270 patent/US6361775B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69517683T2 (en) | 2001-06-07 |
EP0754057A4 (en) | 1997-06-18 |
CA2185470C (en) | 2005-10-25 |
EP0754057A1 (en) | 1997-01-22 |
DE69517683D1 (en) | 2000-08-03 |
US5879675A (en) | 1999-03-09 |
WO1995024924A1 (en) | 1995-09-21 |
AU2158995A (en) | 1995-10-03 |
US6361775B1 (en) | 2002-03-26 |
EP0754057B1 (en) | 2000-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2185470A1 (en) | Compositions and methods for vaccines comprising .alpha.-galactosyl epitopes | |
AU709406C (en) | Combined vaccines comprising hepatitis B surface antigen and other antigens | |
GB2210557B (en) | Vaccine containing tumor antigens and refined detoxified endotoxin as an adjuvant. | |
GB9626483D0 (en) | Helicobacter proteins and vaccines | |
CA2217178A1 (en) | Vaccines containing a saponin and a sterol | |
ZA987591B (en) | Vaccine. | |
CA2172507A1 (en) | Methods and compositions for microencapsulation of antigens for use as vaccines | |
RU98100200A (en) | HELICOBACTER PYLORI ANTIGENS AND VACCINE COMPOSITIONS | |
AU7980794A (en) | Methods and compositions for microencapsulation of antigens for use as vaccines | |
ES500567A0 (en) | PROCEDURE FOR PREPARING VACCINATION COMPLEXES BY REACTION OF RIBONOSAL RNA AND SPECIFIC ANTIGENS. | |
HUP0000318A3 (en) | Tumor vaccine and process for the preparation thereof | |
DK1053017T3 (en) | Vaccines comprising interleukin-12 and herpes simplex virus antigen | |
GB9309414D0 (en) | Measles virus recombinant poxvirus vaccine | |
EP0487909A3 (en) | Novel muramyldipeptide derivatives and influenza vaccine comprising the derivatives | |
AU7237391A (en) | Carrier-bound recombinant protein, process for producing it and its use as an immunogen and vaccine | |
IL71953A (en) | Malaria associated antigen,process for preparation thereof and vaccine comprising it | |
ZA9710205B (en) | Bacterial antigens and vaccine compositions II. | |
CA2273922A1 (en) | Novel saponin compositions and uses thereof | |
ITRM910385A0 (en) | VACCINES USING ERYTHROCYTES AS VEHICLES OF ANTIGENS. | |
AU6761301A (en) | Adjuvant composition comprising fha protein or fragment of fha protein in free form | |
EP0344211A4 (en) | Monoclonal antibodies in vaccine formulations. | |
GB2238959B (en) | Antigen and conjugates thereof for suppressing immune response | |
GB9309161D0 (en) | Footrot antigens,vaccines and diagnostic assays | |
GB9021286D0 (en) | Antigens and antibodies thereto their uses | |
NZ220611A (en) | 30 residue influenza virus peptide, vaccines and antibodies |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20150313 |