CA2178602A1 - Microcapsules, method of making and their use - Google Patents

Microcapsules, method of making and their use

Info

Publication number
CA2178602A1
CA2178602A1 CA002178602A CA2178602A CA2178602A1 CA 2178602 A1 CA2178602 A1 CA 2178602A1 CA 002178602 A CA002178602 A CA 002178602A CA 2178602 A CA2178602 A CA 2178602A CA 2178602 A1 CA2178602 A1 CA 2178602A1
Authority
CA
Canada
Prior art keywords
microcapsules
optionally
biodegradable
spherical
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002178602A
Other languages
French (fr)
Other versions
CA2178602C (en
Inventor
Michel Schneider
Philippe Bussat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Michel Schneider
Philippe Bussat
Bracco Research S.A.
Bracco Suisse S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michel Schneider, Philippe Bussat, Bracco Research S.A., Bracco Suisse S.A. filed Critical Michel Schneider
Publication of CA2178602A1 publication Critical patent/CA2178602A1/en
Application granted granted Critical
Publication of CA2178602C publication Critical patent/CA2178602C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Abstract

The invention relates to micro capsules with a mean size from a fraction of micrometer to 1000 micrometers having a biodegradable membrane encapsulating a gas cone. The membrane comprising one or more biodegradable water insoluble lipids or mixtures thereof and optionally mixtures of the lipids with up to 75 % by weight of biodegradable polymers encapsulates the core which is filled with air or a gas. Microcapsules disclosed, may be non-coalescent, dry and instantly dispersible, when in suspension in a physiologically acceptable carrier are useful as delivery vehicles for therapeutically active agents and/or as contrast agents for echographic imaging of organs of human or animal body. The microcapsules of the invention are made by a method in which a water-in-oil emulsion is made from am organic solution comprising dissolved a mono-, di-, triglyceride preferably tripalmitin or tristearin and optionally therapeutically active substance and an aqueous solution containing a surfactant, optionally evaporating part of the solvent, adding a redispersing agent and freeze drying the mixture. The freeze dried mixture is then redispersed in an aqueous carrier to separate microcapsules from debris and the semi-spherical or spherical microcapsules are dried.
CA002178602A 1994-11-22 1995-11-21 Microcapsules, method of making and their use Expired - Fee Related CA2178602C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94810660 1994-11-22
EP94810660.4 1994-11-22
PCT/IB1995/001029 WO1996015815A1 (en) 1994-11-22 1995-11-21 Microcapsules, method of making and their use

Publications (2)

Publication Number Publication Date
CA2178602A1 true CA2178602A1 (en) 1996-05-30
CA2178602C CA2178602C (en) 2004-03-30

Family

ID=8218339

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002178602A Expired - Fee Related CA2178602C (en) 1994-11-22 1995-11-21 Microcapsules, method of making and their use

Country Status (20)

Country Link
US (2) US6333021B1 (en)
EP (1) EP0755270B1 (en)
JP (1) JP4202414B2 (en)
KR (1) KR100416163B1 (en)
CN (1) CN1066964C (en)
AT (1) ATE337795T1 (en)
AU (1) AU709240B2 (en)
CA (1) CA2178602C (en)
CZ (1) CZ291178B6 (en)
DE (1) DE69535203T2 (en)
ES (1) ES2271947T3 (en)
FI (1) FI120081B (en)
HU (1) HU226896B1 (en)
IL (1) IL116081A (en)
MX (1) MX9602697A (en)
NO (1) NO315692B1 (en)
PL (1) PL182989B1 (en)
RU (1) RU2139046C1 (en)
WO (1) WO1996015815A1 (en)
ZA (1) ZA959941B (en)

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Also Published As

Publication number Publication date
NO962843L (en) 1996-07-05
DE69535203T2 (en) 2007-07-19
CA2178602C (en) 2004-03-30
CZ214096A3 (en) 1996-10-16
DE69535203D1 (en) 2006-10-12
FI120081B (en) 2009-06-30
US6333021B1 (en) 2001-12-25
HU9601996D0 (en) 1996-09-30
EP0755270A1 (en) 1997-01-29
EP0755270B1 (en) 2006-08-30
HUT74912A (en) 1997-03-28
NO962843D0 (en) 1996-07-05
MX9602697A (en) 1998-06-28
AU3814495A (en) 1996-06-17
US6403057B1 (en) 2002-06-11
HU226896B1 (en) 2010-01-28
WO1996015815A1 (en) 1996-05-30
FI962917A0 (en) 1996-07-19
NO315692B1 (en) 2003-10-13
CZ291178B6 (en) 2003-01-15
IL116081A0 (en) 1996-01-31
JPH09511762A (en) 1997-11-25
CN1066964C (en) 2001-06-13
ES2271947T3 (en) 2007-04-16
FI962917A (en) 1996-07-19
CN1139386A (en) 1997-01-01
ATE337795T1 (en) 2006-09-15
IL116081A (en) 2003-04-10
KR100416163B1 (en) 2004-03-19
PL315585A1 (en) 1996-11-12
PL182989B1 (en) 2002-05-31
JP4202414B2 (en) 2008-12-24
RU2139046C1 (en) 1999-10-10
AU709240B2 (en) 1999-08-26
ZA959941B (en) 1996-06-10

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