CA2177543A1 - Containers for liquid medicaments - Google Patents

Containers for liquid medicaments

Info

Publication number
CA2177543A1
CA2177543A1 CA002177543A CA2177543A CA2177543A1 CA 2177543 A1 CA2177543 A1 CA 2177543A1 CA 002177543 A CA002177543 A CA 002177543A CA 2177543 A CA2177543 A CA 2177543A CA 2177543 A1 CA2177543 A1 CA 2177543A1
Authority
CA
Canada
Prior art keywords
tube
container
piston
suspension
containers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002177543A
Other languages
French (fr)
Other versions
CA2177543C (en
Inventor
Clemens Micheler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CA2177543A1 publication Critical patent/CA2177543A1/en
Application granted granted Critical
Publication of CA2177543C publication Critical patent/CA2177543C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/062—Carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/24—Mixing the contents of independent containers, e.g. test tubes the containers being submitted to a rectilinear movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/32005—Type of drive
    • B01F35/3202—Hand driven
    • B01F35/32021—Shaking by hand a portable receptacle or stirrer for mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/32005—Type of drive
    • B01F35/3202—Hand driven
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00—Surgery
    • Y10S604/903—Medical container with material agitation means

Abstract

A container 10 for a liquid medicament suspension, e.g. an insulin crystal suspension, has a tube 11 with a sealing piston 13, a cap 16, and a mixing element 20 which moves along the tube 11 to assist mixing the suspension. The element 20 is guided by the inner surface of the tube 11 and has restricted lateral movement but is free to move axially, for example, by tilting or end to end inversion of the container. Flow passages such as apertures and peripheral recesses are provided in the mixing element which can serve to promote turbulent flow. The containers are particularly suited for use as multi-dose cartridges for pen-like injection devices or for portable infusion devices which have piston-operating mechanisms to co-operate with the container piston.
CA002177543A 1995-06-02 1996-05-28 Containers for liquid medicaments Expired - Lifetime CA2177543C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9511169.6 1995-06-02
GBGB9511169.6A GB9511169D0 (en) 1995-06-02 1995-06-02 Containers for liquid medicaments

Publications (2)

Publication Number Publication Date
CA2177543A1 true CA2177543A1 (en) 1996-12-03
CA2177543C CA2177543C (en) 2007-09-25

Family

ID=10775402

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002177543A Expired - Lifetime CA2177543C (en) 1995-06-02 1996-05-28 Containers for liquid medicaments

Country Status (12)

Country Link
US (1) US5725500A (en)
EP (1) EP0745369B1 (en)
JP (1) JP3816149B2 (en)
AT (1) ATE213146T1 (en)
CA (1) CA2177543C (en)
DE (1) DE69619159T2 (en)
DK (1) DK0745369T3 (en)
ES (1) ES2168439T3 (en)
GB (1) GB9511169D0 (en)
MX (1) MX9602029A (en)
PT (1) PT745369E (en)
SI (1) SI0745369T1 (en)

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AU4492800A (en) * 1999-04-30 2000-12-12 Eli Lilly And Company Cartridge assembly for medicament suspensions
US6554792B2 (en) 1999-05-21 2003-04-29 Mallinckrodt Inc. Suspension device and method
US6357907B1 (en) * 1999-06-15 2002-03-19 V & P Scientific, Inc. Magnetic levitation stirring devices and machines for mixing in vessels
US6379032B1 (en) 2000-02-18 2002-04-30 Steve Sorensen Flow-through agitator
CA2407335C (en) * 2000-05-03 2010-08-03 Joe D'silva Process and device for producing liquid dosage formulations
KR20040029015A (en) * 2001-08-31 2004-04-03 노보 노르디스크 에이/에스 A cartridge for liquid insulin
US20030100883A1 (en) * 2001-08-31 2003-05-29 Kristensen Lars Thougaard Cartridge for liquid insulin
US20030163084A1 (en) * 2001-12-20 2003-08-28 Klaus Tiemann Creation and agitation of multi-component fluids in injection systems
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US20050215954A1 (en) * 2004-03-29 2005-09-29 Mallinckrodt Inc. Apparatus and method for maintaining suspendible agents in suspension
CN100571802C (en) * 2005-05-03 2009-12-23 诺和诺德公司 Drug suspension and the cartridge case with hybrid element of different densities are housed
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WO2007114934A2 (en) * 2006-04-04 2007-10-11 Vnus Medical Technologies, Inc. Method and apparatus for generating vascular treatment foam
US7547300B2 (en) 2006-04-12 2009-06-16 Icu Medical, Inc. Vial adaptor for regulating pressure
DE502007005003D1 (en) * 2006-04-21 2010-10-21 Vetter & Co Apotheker SYRINGE CYLINDER
PL2056903T3 (en) * 2006-08-31 2019-04-30 Meridian Medical Tech Inc Vortex feature for drug delivery system
US7883499B2 (en) 2007-03-09 2011-02-08 Icu Medical, Inc. Vial adaptors and vials for regulating pressure
WO2009044401A2 (en) 2007-10-02 2009-04-09 Yossi Gross External drug pump
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WO2010022095A1 (en) 2008-08-20 2010-02-25 Icu Medical, Inc. Anti-reflux vial adaptors
EP2158927A1 (en) * 2008-08-25 2010-03-03 Debiotech S.A. Drug delivery device with a module for preventing fibrillation downstream of its reservoir
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WO2013106757A1 (en) 2012-01-13 2013-07-18 Icu Medical, Inc. Pressure-regulating vial adaptors and methods
US9751056B2 (en) 2012-01-23 2017-09-05 Merit Medical Systems, Inc. Mixing syringe
US8834449B2 (en) 2012-01-23 2014-09-16 Ikomed Technologies, Inc. Mixing syringe
DE102012202146A1 (en) * 2012-02-13 2013-08-14 Bayerische Motoren Werke Aktiengesellschaft Storage tank of cryogenic compressed gas with a storage volume
US10207053B2 (en) 2012-03-16 2019-02-19 Becton, Dickinson And Company Drug delivery device for drug suspensions
AU2013204180B2 (en) 2012-03-22 2016-07-21 Icu Medical, Inc. Pressure-regulating vial adaptors
DE102012008815B4 (en) * 2012-05-07 2014-03-06 Heraeus Medical Gmbh Mixing device for multi-component systems
US9089475B2 (en) 2013-01-23 2015-07-28 Icu Medical, Inc. Pressure-regulating vial adaptors
ES2739291T3 (en) 2013-01-23 2020-01-30 Icu Medical Inc Pressure regulation vial adapters
US9555379B2 (en) * 2013-03-13 2017-01-31 Bayer Healthcare Llc Fluid path set with turbulent mixing chamber, backflow compensator
WO2014145906A2 (en) 2013-03-15 2014-09-18 Phd Preventative Health Care And Diagnostics, Inc. A prefilled medication device, method of making and using the same
JP6617101B2 (en) 2013-07-19 2019-12-04 アイシーユー メディカル インコーポレイテッド Pressure regulating fluid transfer system and method
ES2759975T3 (en) * 2013-09-06 2020-05-12 Terumo Corp Outer tube of syringe and mold for injection molding
US10399083B2 (en) 2014-01-06 2019-09-03 Omni International, Inc. Flow disrupters for use with homogenization tubes for beadless interrupted flow
AU2015277135B2 (en) 2014-06-20 2020-02-20 Icu Medical, Inc. Pressure-regulating vial adaptors
USD959694S1 (en) * 2015-04-01 2022-08-02 Novartis Ag Container for pharmaceuticals
USD776482S1 (en) * 2015-05-15 2017-01-17 Ningbo Tianqi Molding Co., Ltd. Churning ball
USD776478S1 (en) * 2015-08-05 2017-01-17 Cotapaxi Custom Designs and Manufacturing, LLC Mixing ball
US10576207B2 (en) 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
JP7017512B2 (en) 2015-10-09 2022-02-08 ウェスト ファーマ サービシーズ イスラエル リミテッド Bending fluid path type accessories for filled fluid containers
JP6542481B2 (en) 2016-01-21 2019-07-10 ウェスト ファーマ サービシーズ イスラエル リミテッド system
CN113041432B (en) 2016-01-21 2023-04-07 西医药服务以色列有限公司 Medicament delivery device comprising a visual indicator
EP3711793B1 (en) 2016-01-21 2021-12-01 West Pharma Services IL, Ltd. A method of connecting a cartridge to an automatic injector
CA3012733C (en) 2016-01-29 2023-09-12 Icu Medical, Inc. Pressure-regulating vial adaptors
EP3423130A1 (en) 2016-03-03 2019-01-09 Bayer Healthcare LLC System and method for improved fluid delivery in multi-fluid injector systems
US11389597B2 (en) 2016-03-16 2022-07-19 West Pharma. Services IL, Ltd. Staged telescopic screw assembly having different visual indicators
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CN106955236B (en) * 2017-05-09 2019-11-22 李爱华 Easy dispensing injector with pin
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US11478581B2 (en) 2017-08-31 2022-10-25 Bayer Healthcare Llc Fluid injector system volume compensation system and method
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Also Published As

Publication number Publication date
ATE213146T1 (en) 2002-02-15
EP0745369B1 (en) 2002-02-13
DE69619159T2 (en) 2002-06-20
PT745369E (en) 2002-06-28
EP0745369A3 (en) 1997-03-26
US5725500A (en) 1998-03-10
SI0745369T1 (en) 2002-06-30
JP3816149B2 (en) 2006-08-30
EP0745369A2 (en) 1996-12-04
JPH0999034A (en) 1997-04-15
MX9602029A (en) 1997-08-30
CA2177543C (en) 2007-09-25
DE69619159D1 (en) 2002-03-21
DK0745369T3 (en) 2002-03-25
GB9511169D0 (en) 1995-07-26
ES2168439T3 (en) 2002-06-16

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20160530