CA2177492A1 - Preparation of hollow microcapsules - Google Patents

Preparation of hollow microcapsules

Info

Publication number
CA2177492A1
CA2177492A1 CA002177492A CA2177492A CA2177492A1 CA 2177492 A1 CA2177492 A1 CA 2177492A1 CA 002177492 A CA002177492 A CA 002177492A CA 2177492 A CA2177492 A CA 2177492A CA 2177492 A1 CA2177492 A1 CA 2177492A1
Authority
CA
Canada
Prior art keywords
microcapsules
preparation
hollow microcapsules
solution
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002177492A
Other languages
French (fr)
Other versions
CA2177492C (en
Inventor
Nicholas Osborne
Andrew Derek Sutton
Richard Alan Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Drug Delivery Ltd
Original Assignee
Nicholas Osborne
Andrew Derek Sutton
Richard Alan Johnson
Andaris Limited
Quadrant Healthcare (Uk) Limited
Quadrant Holdings Cambridge Limited
Elan Drug Delivery Limited
Quadrant Drug Delivery Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10764705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2177492(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nicholas Osborne, Andrew Derek Sutton, Richard Alan Johnson, Andaris Limited, Quadrant Healthcare (Uk) Limited, Quadrant Holdings Cambridge Limited, Elan Drug Delivery Limited, Quadrant Drug Delivery Limited filed Critical Nicholas Osborne
Publication of CA2177492A1 publication Critical patent/CA2177492A1/en
Application granted granted Critical
Publication of CA2177492C publication Critical patent/CA2177492C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B01J13/043—Drying and spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Abstract

A process for forming microcapsules comprising (i) providing a solution of protein in an aqueous solvent and (ii) spraying the said solution into a gas such that the aqueous solvent evaporates, thereby forming hollow microcapsules, characterised in that the aqueous solution contains a liquid of greater volatility than water. The protein is preferably ethanol. The microcapsules may be used as ultrasound echogenic contrast agents.
CA002177492A 1994-11-19 1995-11-15 Preparation of hollow microcapsules Expired - Fee Related CA2177492C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9423419.2 1994-11-19
GB9423419A GB9423419D0 (en) 1994-11-19 1994-11-19 Preparation of hollow microcapsules
PCT/GB1995/002673 WO1996015814A1 (en) 1994-11-19 1995-11-15 Preparation of hollow microcapsules

Publications (2)

Publication Number Publication Date
CA2177492A1 true CA2177492A1 (en) 1996-05-30
CA2177492C CA2177492C (en) 2003-03-25

Family

ID=10764705

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002177492A Expired - Fee Related CA2177492C (en) 1994-11-19 1995-11-15 Preparation of hollow microcapsules

Country Status (19)

Country Link
US (2) US5741478A (en)
EP (1) EP0743860B2 (en)
JP (1) JP4592831B2 (en)
KR (1) KR100188356B1 (en)
CN (1) CN1072966C (en)
AT (1) ATE216595T1 (en)
AU (1) AU681815B2 (en)
CA (1) CA2177492C (en)
DE (1) DE69526491T3 (en)
DK (1) DK0743860T3 (en)
ES (1) ES2174968T3 (en)
GB (2) GB9423419D0 (en)
HK (1) HK1013405A1 (en)
NO (1) NO313491B1 (en)
PT (1) PT743860E (en)
RU (1) RU2193397C2 (en)
SG (1) SG81230A1 (en)
WO (1) WO1996015814A1 (en)
ZA (1) ZA959801B (en)

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Also Published As

Publication number Publication date
AU681815B2 (en) 1997-09-04
EP0743860B2 (en) 2008-12-31
EP0743860B1 (en) 2002-04-24
CN1138828A (en) 1996-12-25
SG81230A1 (en) 2001-06-19
ES2174968T3 (en) 2002-11-16
DE69526491T2 (en) 2002-10-31
MX9602851A (en) 1997-12-31
GB9423419D0 (en) 1995-01-11
ZA959801B (en) 1996-08-28
DK0743860T3 (en) 2002-08-12
DE69526491D1 (en) 2002-05-29
NO962994L (en) 1996-07-18
PT743860E (en) 2002-10-31
CN1072966C (en) 2001-10-17
GB2298628B (en) 1998-08-05
US5741478A (en) 1998-04-21
JP4592831B2 (en) 2010-12-08
ATE216595T1 (en) 2002-05-15
NO313491B1 (en) 2002-10-14
NO962994D0 (en) 1996-07-18
GB2298628A (en) 1996-09-11
CA2177492C (en) 2003-03-25
RU2193397C2 (en) 2002-11-27
KR100188356B1 (en) 1999-06-01
GB9610968D0 (en) 1996-07-31
HK1013405A1 (en) 1999-08-27
WO1996015814A1 (en) 1996-05-30
AU3853395A (en) 1996-06-17
DE69526491T3 (en) 2009-07-30
EP0743860A1 (en) 1996-11-27
US6623722B1 (en) 2003-09-23
JPH09508067A (en) 1997-08-19

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