CA2174236A1 - Superoxide dismutase and mimetics thereof - Google Patents

Superoxide dismutase and mimetics thereof

Info

Publication number
CA2174236A1
CA2174236A1 CA002174236A CA2174236A CA2174236A1 CA 2174236 A1 CA2174236 A1 CA 2174236A1 CA 002174236 A CA002174236 A CA 002174236A CA 2174236 A CA2174236 A CA 2174236A CA 2174236 A1 CA2174236 A1 CA 2174236A1
Authority
CA
Canada
Prior art keywords
mimetics
superoxide dismutase
relates
radicals
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002174236A
Other languages
French (fr)
Other versions
CA2174236C (en
Inventor
James D. Crapo
Irwin Fridovich
Tim Oury
Brian J. Day
Rodney J. Folz
Bruce A. Freeman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UAB Research Foundation
Duke University
Original Assignee
James D. Crapo
Irwin Fridovich
Tim Oury
Brian J. Day
Rodney J. Folz
Bruce A. Freeman
Duke University
University Of Alabama At Birmingham Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman, Duke University, University Of Alabama At Birmingham Research Foundation filed Critical James D. Crapo
Priority to CA002614621A priority Critical patent/CA2614621A1/en
Publication of CA2174236A1 publication Critical patent/CA2174236A1/en
Application granted granted Critical
Publication of CA2174236C publication Critical patent/CA2174236C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A61K47/546—Porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of superoxide radicals and thereby processes in which such radicals are a participant.
The invention also relates to compounds and compositions suitable for use in such methods.
CA002174236A 1993-10-15 1994-10-13 Superoxide dismutase and mimetics thereof Expired - Lifetime CA2174236C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002614621A CA2614621A1 (en) 1993-10-15 1994-10-13 Superoxide dismutase and mimetics thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13620793A 1993-10-15 1993-10-15
US136,207 1993-10-15
PCT/US1994/011558 WO1995010185A1 (en) 1993-10-15 1994-10-13 Superoxide dismutase and mimetics thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002614621A Division CA2614621A1 (en) 1993-10-15 1994-10-13 Superoxide dismutase and mimetics thereof

Publications (2)

Publication Number Publication Date
CA2174236A1 true CA2174236A1 (en) 1995-04-20
CA2174236C CA2174236C (en) 2008-02-12

Family

ID=22471830

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002174236A Expired - Lifetime CA2174236C (en) 1993-10-15 1994-10-13 Superoxide dismutase and mimetics thereof

Country Status (9)

Country Link
US (1) US5747026A (en)
EP (2) EP0723398B1 (en)
JP (1) JPH09505805A (en)
AT (1) ATE291351T1 (en)
AU (1) AU702596B2 (en)
CA (1) CA2174236C (en)
DE (1) DE69434313T2 (en)
ES (1) ES2237753T3 (en)
WO (1) WO1995010185A1 (en)

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US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
AU3758695A (en) * 1994-09-20 1996-04-09 Duke University Oxidoreductase activity of manganic porphyrins
EP0831891B1 (en) * 1995-06-07 2005-10-19 Duke University Oxidant scavengers
EP0846003A1 (en) * 1995-08-17 1998-06-10 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
CA2183834C (en) * 1995-08-22 2003-09-09 Hiroshi Maeda Antihypertensive agents containing pyrazolopyrimidine derivatives
CZ271198A3 (en) * 1996-03-13 1999-01-13 Monsanto Company Manganese bioconjugates of iron complexes of macrocyclic ligands containing nitrogen, acting as catalysts for superoxide dismutation
WO1999023097A1 (en) * 1997-11-03 1999-05-14 Duke University Substituted porphyrins
DE69928655T2 (en) 1998-04-24 2006-08-24 Duke University SUBSTITUTED PORPHYRINE
AU5673099A (en) 1998-08-11 2000-03-06 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Inhibitors of amyloid formation
GB9817845D0 (en) 1998-08-17 1998-10-14 Glaxo Group Ltd Chemical compounds
WO2000023568A2 (en) * 1998-10-06 2000-04-27 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for decreasing mitochondrial overproduction of reactive oxygen species in cells
US6695830B2 (en) * 1999-01-15 2004-02-24 Scimed Life Systems, Inc. Method for delivering medication into an arterial wall for prevention of restenosis
US6210392B1 (en) * 1999-01-15 2001-04-03 Interventional Technologies, Inc. Method for treating a wall of a blood vessel
AU779283B2 (en) * 1999-01-25 2005-01-13 Aeolus Sciences, Inc. Substituted porphyrins
IT1306716B1 (en) * 1999-06-21 2001-10-02 Mendes S U R L ASSOCIATION OF LACTIC BACTERIA AND ITS USE FOR THE PREVENTION AND / OR THERAPEUTIC TREATMENT OF INFECTIONS AND INFLAMMATORY STATES.
SE9903985D0 (en) * 1999-11-03 1999-11-03 Aga Ab Use of nitric oxide
FR2806911B1 (en) * 2000-03-28 2003-01-10 Univ Rene Descartes USE OF SOD MIMETICS IN THE TREATMENT OF HEPATOCELLULAR DEFICIENCIES
US6403788B1 (en) 2000-07-11 2002-06-11 Eukarion, Inc. Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species
WO2002022573A2 (en) * 2000-09-15 2002-03-21 The Scripps Research Institute Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies
US20020072512A1 (en) * 2000-12-08 2002-06-13 Metaphore Pharmaceuticals, Inc Method of preventing and treating HIV-mediated central nervous system damage
AU2002248366B2 (en) * 2001-01-19 2006-10-26 Aeolus Sciences, Inc. Cancer therapy
EP1353655A2 (en) * 2001-01-26 2003-10-22 Metaphore Pharmaceuticals Inc. Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes
EP1439842A4 (en) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
US20040116350A1 (en) * 2001-09-17 2004-06-17 Paul Wentworth Jr Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies
US20050129680A1 (en) * 2001-09-17 2005-06-16 Paul Wentworth Antimicrobial activity of antibodies
US20040157280A1 (en) * 2001-09-17 2004-08-12 Paul Wentworth Antibody mediated ozone generation
WO2003072053A2 (en) 2002-02-22 2003-09-04 The Curators Of The University Of Missouri Compounds for treatment of copper overload
EP1513537A4 (en) * 2002-06-07 2006-09-06 Univ Duke Substituted porphyrins
WO2004044582A2 (en) * 2002-11-14 2004-05-27 Novartis Ag Antibody- or neutrophil-mediated ozone generation
MXPA05011773A (en) 2003-05-01 2006-02-17 Cornell Res Foundation Inc Method and carrier complexes for delivering molecules to cells.
US7432369B2 (en) 2004-03-29 2008-10-07 Inotek Pharmaceuticals Corporation Pyridyl-substituted porphyrin compounds and methods of use thereof
WO2008018932A2 (en) 2006-05-01 2008-02-14 The Board Of Trustees Of The Leland Stanford Junior University Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury
EP2300032A4 (en) 2008-05-13 2012-12-05 Univ Kansas Metal abstraction peptide (map) tag and associated methods
US11382895B2 (en) 2008-05-23 2022-07-12 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
JP4891367B2 (en) 2009-05-21 2012-03-07 トヨタ自動車株式会社 Solvent composition
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
WO2013181461A2 (en) 2012-06-01 2013-12-05 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
CN104190927B (en) 2014-08-11 2016-05-18 苏州大学 A kind of synchronous powder feeding system space laser processing and three-dimensional method and device

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US4758422A (en) * 1985-01-04 1988-07-19 Salutar Inc. Ferrioxamine paramagnetic contrast agents for MR imaging
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US5171680A (en) * 1988-06-14 1992-12-15 Chiron Corporation Superoxide dismutase analogs having novel binding properties
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US5202317A (en) * 1990-09-13 1993-04-13 The Regents Of The University Of California Synthetic drug molecules that mimic metalloenzymes
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Also Published As

Publication number Publication date
AU7976394A (en) 1995-05-04
EP0723398B1 (en) 2005-03-23
WO1995010185A1 (en) 1995-04-20
DE69434313T2 (en) 2006-03-30
ES2237753T3 (en) 2005-08-01
DE69434313D1 (en) 2005-04-28
CA2174236C (en) 2008-02-12
AU702596B2 (en) 1999-02-25
ATE291351T1 (en) 2005-04-15
EP1442747A1 (en) 2004-08-04
EP0723398A4 (en) 1999-03-24
EP0723398A1 (en) 1996-07-31
US5747026A (en) 1998-05-05
JPH09505805A (en) 1997-06-10

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Legal Events

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EEER Examination request
MKEX Expiry

Effective date: 20141014