CA2174209A1 - Phosphorescent compounds for imaging tissue oxygen - Google Patents
Phosphorescent compounds for imaging tissue oxygenInfo
- Publication number
- CA2174209A1 CA2174209A1 CA002174209A CA2174209A CA2174209A1 CA 2174209 A1 CA2174209 A1 CA 2174209A1 CA 002174209 A CA002174209 A CA 002174209A CA 2174209 A CA2174209 A CA 2174209A CA 2174209 A1 CA2174209 A1 CA 2174209A1
- Authority
- CA
- Canada
- Prior art keywords
- phosphorescent compounds
- tissue oxygen
- imaging tissue
- compounds
- chromophore
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/223—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols
- G01N31/225—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols for oxygen, e.g. including dissolved oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/14—Coupling media or elements to improve sensor contact with skin or tissue
- A61B2562/146—Coupling media or elements to improve sensor contact with skin or tissue for optical coupling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
Abstract
Methods and compounds for the measurement in vivo of oxygen in living tissue. The compounds preferably comprise a chromophore which is capable of absorbing an amount of energy and subsequently releasing the energy as phosphorescent light. In preferred embodiments, the chromophore has an absorption band which is at a wavelength in the near infrared window of living tissue and the phosphorescence is quenched by molecular oxygen according to the Stern-Volmer relationship.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/137,624 US6362175B1 (en) | 1991-09-20 | 1993-10-15 | Porphyrin compounds for imaging tissue oxygen |
US08/137,624 | 1993-10-15 | ||
PCT/US1994/011695 WO1995010522A1 (en) | 1993-10-15 | 1994-10-14 | Phosphorescent compounds for imaging tissue oxygen |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2174209A1 true CA2174209A1 (en) | 1995-04-20 |
CA2174209C CA2174209C (en) | 2005-01-25 |
Family
ID=22478306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002174209A Expired - Fee Related CA2174209C (en) | 1993-10-15 | 1994-10-14 | Phosphorescent compounds for imaging tissue oxygen |
Country Status (7)
Country | Link |
---|---|
US (1) | US6362175B1 (en) |
EP (1) | EP0723548B1 (en) |
AT (1) | ATE455116T1 (en) |
AU (1) | AU700941B2 (en) |
CA (1) | CA2174209C (en) |
DE (1) | DE69435265D1 (en) |
WO (1) | WO1995010522A1 (en) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593899A (en) * | 1993-02-25 | 1997-01-14 | Trustees Of The University Of Pennsylvania | Device and method for measuring tissue oxygenation through the skin using oxygen dependent quenching of phosphorescence |
US5837865A (en) * | 1993-10-15 | 1998-11-17 | Trustees Of The University Of Pennsylvania | Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen |
DE19627164C2 (en) * | 1996-07-05 | 1998-09-24 | Deutsches Krebsforsch | Production of polyether-containing chlorins and bacteriochlorins, such compounds and their use |
AU3769597A (en) | 1996-07-22 | 1998-02-10 | Novartis Ag | Process for the preparation of platinum or palladium benzoporphyrins and platinum or palladium cyclohexenoporphyrins, intermediates, and an oxygen sensor comprising platinum or palladium cyclohexenoporphyrin |
US5830138A (en) * | 1996-12-16 | 1998-11-03 | Trustees Of The University Of Pennsylvania | Intravascular catheter probe for clinical oxygen, pH and CO2 measurement |
US6274086B1 (en) * | 1996-12-16 | 2001-08-14 | The Trustees Of The University Of Pennsylvania | Apparatus for non-invasive imaging oxygen distribution in multi-dimensions |
US6165741A (en) * | 1997-05-30 | 2000-12-26 | The Trustees Of The University Of Pennsylvania | Method for rapid detection of bacterial growth in cultures |
US6254831B1 (en) | 1998-01-21 | 2001-07-03 | Bayer Corporation | Optical sensors with reflective materials |
US6190612B1 (en) | 1998-01-21 | 2001-02-20 | Bayer Corporation | Oxygen sensing membranes and methods of making same |
US6306347B1 (en) | 1998-01-21 | 2001-10-23 | Bayer Corporation | Optical sensor and method of operation |
US6107083A (en) * | 1998-08-21 | 2000-08-22 | Bayer Corporation | Optical oxidative enzyme-based sensors |
JP5000050B2 (en) * | 2001-08-31 | 2012-08-15 | 浩 前田 | Antitumor agent and method for producing the same |
DK1494579T3 (en) * | 2002-04-02 | 2011-11-14 | Yeda Res & Dev | Characterization of moving objects in a stationary background |
AU2002951886A0 (en) * | 2002-10-08 | 2002-10-24 | The Western Australian Centre For Pathology And Medical Research | A method for measuring antioxident status |
GB2397067B (en) * | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
EP1601955B1 (en) * | 2003-03-07 | 2013-01-09 | Luxcel Biosciences Limited | An oxygen sensitive probe and method for measuring oxygen uptake |
JP2005290282A (en) * | 2004-04-02 | 2005-10-20 | Fuji Photo Film Co Ltd | Process for producing phthalocyanine |
GB2415372A (en) | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
US8172763B2 (en) * | 2005-05-06 | 2012-05-08 | Yeda Research And Development Co., Ltd. | Imaging and analysis of movement of erythrocytes in blood vessels in relation to the cardiac cycle |
EP2679155A1 (en) * | 2006-01-04 | 2014-01-01 | The Trustees of The University of Pennsylvania | Oxygen sensor for internal monitoring of tissue oxygen in vivo |
US7575890B2 (en) * | 2006-01-18 | 2009-08-18 | Oxygen Enterprises, Ltd. | Method for rapid detection and evaluation of cultured cell growth |
US8403862B2 (en) * | 2007-12-20 | 2013-03-26 | Yeda Research And Development Co. Ltd. | Time-based imaging |
WO2009108947A2 (en) * | 2008-02-28 | 2009-09-03 | The Trustees Of The University Of Pennsylvania | Imaging dendrimer nanoprobes and uses thereof |
US8323978B2 (en) * | 2008-11-07 | 2012-12-04 | Mocon, Inc. | Calibration system and technique for photoluminescent oxygen sensors with zero point maintained with a metal-air battery |
EP2350614A4 (en) * | 2008-11-07 | 2017-01-11 | Mocon, Inc. | Calibration card for oxygen optical sensors |
US8241911B2 (en) * | 2008-11-07 | 2012-08-14 | Mocon, Inc. | Calibration card for photoluminescent oxygen sensors with zero point maintained with a metal-air battery |
US20110136247A1 (en) * | 2009-12-07 | 2011-06-09 | Dmitri Boris Papkovsky | Photoluminescent oxygen probe with reduced cross-sensitivity to humidity |
US9274060B1 (en) | 2011-01-13 | 2016-03-01 | Mocon, Inc. | Methods for transmembrane measurement of oxygen concentration and monitoring changes in oxygen concentration within a space enclosed by a membrane employing a photoluminescent transmembrane oxygen probe |
US9121827B2 (en) | 2011-06-30 | 2015-09-01 | Mocon, Inc. | Method of contemporaneously monitoring changes in analyte concentration in a plurality of samples on individual schedules |
WO2013130510A1 (en) * | 2012-02-27 | 2013-09-06 | Sergei Vinogradov | Improved phosphorescent molecules for measuring oxygen and imaging methods |
US10493168B2 (en) * | 2012-02-27 | 2019-12-03 | Oxygen Enterprises, Ltd | Phosphorescent meso-unsubstituted metallo-porphyrin probe molecules for measuring oxygen and imaging methods |
US9057687B2 (en) | 2012-04-20 | 2015-06-16 | Mocon, Inc. | Calibration vial and technique for calibrating a fiber optic oxygen sensing needle |
US10016164B2 (en) | 2012-07-10 | 2018-07-10 | The General Hospital Corporation | System and method for monitoring and treating a surface of a subject |
US8658429B1 (en) | 2012-08-06 | 2014-02-25 | Mocon, Inc. | Photoluminescent oxygen probe tack |
US10045722B2 (en) | 2013-03-14 | 2018-08-14 | Profusa, Inc. | Method and device for correcting optical signals |
CA2904127C (en) * | 2013-03-14 | 2023-10-17 | Profusa, Inc. | Polymer based oxygen sensors |
EP2976347B1 (en) | 2013-03-15 | 2022-01-19 | McFarland, Sherri Ann | Metal-based coordination complexes as photodynamic compounds and their use |
EP4079242A1 (en) | 2013-03-19 | 2022-10-26 | Surgisense Corporation | Apparatus, systems and methods for determining tissue oxygenation |
US9789206B2 (en) | 2013-07-10 | 2017-10-17 | The General Hospital Corporation | Compounds, systems, and methods for monitoring and treating a surface of a subject |
CN103788952A (en) * | 2014-01-24 | 2014-05-14 | 中国科学院长春光学精密机械与物理研究所 | Highly-doped broadband excited rare earth up-conversion fluorescent nanomaterial and preparation method thereof |
CN112932389A (en) * | 2014-04-05 | 2021-06-11 | 手术感应设备公司 | Imaging system for resolving and mapping physiological conditions |
WO2018119204A1 (en) * | 2016-12-21 | 2018-06-28 | Profusa, Inc. | Polymerizable near-ir dyes |
WO2019006400A1 (en) * | 2017-06-29 | 2019-01-03 | Profusa, Inc. | Multi-analyte sensing tissue-integrating sensors |
CN109216421B (en) * | 2017-07-04 | 2023-10-24 | 三星电子株式会社 | Organic light emitting diode panel and display device including the same |
WO2019194875A2 (en) | 2017-12-28 | 2019-10-10 | Profusa, Inc. | Oxidase-based sensors and methods of using |
CN109470666B (en) * | 2018-11-07 | 2023-11-24 | 上海萨迦生物科技有限公司 | Near infrared laser confocal biochip scanner |
CN113968864B (en) * | 2020-07-23 | 2023-04-07 | 浙大城市学院 | Cu based on zinc porphyrin axial coordination regulation + Fluorescent probe, preparation method and application |
US11874221B2 (en) * | 2021-01-26 | 2024-01-16 | Yokogawa Electric Corporation | Measurement of dissolved oxygen using optical radiation induced luminescence |
CN114516879A (en) * | 2022-02-28 | 2022-05-20 | 上海先辉医药科技有限公司 | Novel intermediate tetraphenyl naphthoporphin derivative and application thereof in medical field |
CN114524822A (en) * | 2022-02-28 | 2022-05-24 | 上海先辉医药科技有限公司 | Novel intermediate diphenyl naphthoporphin derivative and application thereof in medical field |
WO2023178034A1 (en) * | 2022-03-14 | 2023-09-21 | Hollister Incorporated | System and method for detecting oxygen for prediction, detection, mitigation and/or prevention of peristomal skin injury |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2219093A (en) | 1938-02-01 | 1940-10-22 | Lund Otto | Two-stroke internal combustion engine |
US5156840A (en) * | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
GB8805849D0 (en) | 1988-03-11 | 1988-04-13 | Efamol Holdings | Porphyrins & cancer treatment |
US4947850A (en) * | 1988-03-11 | 1990-08-14 | Trustees Of The University Of Pennsylvania | Method and apparatus for imaging an internal body portion of a host animal |
DE3809671A1 (en) | 1988-03-18 | 1989-09-28 | Schering Ag | PORPHYRINE COMPLEX COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
US5227481A (en) * | 1989-07-07 | 1993-07-13 | National Starch And Chemical Investment Holding Corporation | Cationic polysaccharides and reagents for their preparation |
US5238940A (en) * | 1990-03-22 | 1993-08-24 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
US5149801A (en) * | 1990-11-21 | 1992-09-22 | The Regents Of The University Of California | Boronated porphyrin compounds |
US5280115A (en) * | 1991-09-12 | 1994-01-18 | Sun Company, Inc. (R&M) | Nitrated metalloporphyrins as catalysts for alkane oxidation |
US5330741A (en) * | 1992-02-24 | 1994-07-19 | The Regents Of The University Of California | Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors |
GB9408746D0 (en) | 1994-05-03 | 1994-06-22 | Scotia Holdings Plc | Tumour locallising photosensitising compounds |
-
1993
- 1993-10-15 US US08/137,624 patent/US6362175B1/en not_active Expired - Lifetime
-
1994
- 1994-10-14 WO PCT/US1994/011695 patent/WO1995010522A1/en active Application Filing
- 1994-10-14 AU AU79798/94A patent/AU700941B2/en not_active Ceased
- 1994-10-14 CA CA002174209A patent/CA2174209C/en not_active Expired - Fee Related
- 1994-10-14 DE DE69435265T patent/DE69435265D1/en not_active Expired - Lifetime
- 1994-10-14 AT AT94930778T patent/ATE455116T1/en not_active IP Right Cessation
- 1994-10-14 EP EP94930778A patent/EP0723548B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6362175B1 (en) | 2002-03-26 |
AU7979894A (en) | 1995-05-04 |
EP0723548A1 (en) | 1996-07-31 |
CA2174209C (en) | 2005-01-25 |
ATE455116T1 (en) | 2010-01-15 |
EP0723548A4 (en) | 1997-01-15 |
WO1995010522A1 (en) | 1995-04-20 |
DE69435265D1 (en) | 2010-03-04 |
EP0723548B1 (en) | 2010-01-13 |
AU700941B2 (en) | 1999-01-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20131015 |