CA2170660A1 - Method and apparatus for reduction of bias in amperometric sensors - Google Patents

Method and apparatus for reduction of bias in amperometric sensors

Info

Publication number
CA2170660A1
CA2170660A1 CA002170660A CA2170660A CA2170660A1 CA 2170660 A1 CA2170660 A1 CA 2170660A1 CA 002170660 A CA002170660 A CA 002170660A CA 2170660 A CA2170660 A CA 2170660A CA 2170660 A1 CA2170660 A1 CA 2170660A1
Authority
CA
Canada
Prior art keywords
analyte
potential
test sample
concentration
fluid test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002170660A
Other languages
French (fr)
Other versions
CA2170660C (en
Inventor
Marvin A. Genshaw
Dijia Huang
Matthew K. Musho
Kin-Fai Yip
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ascensia Diabetes Care Holdings AG
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23730666&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2170660(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Corp filed Critical Bayer Corp
Priority to CA002416606A priority Critical patent/CA2416606C/en
Publication of CA2170660A1 publication Critical patent/CA2170660A1/en
Application granted granted Critical
Publication of CA2170660C publication Critical patent/CA2170660C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/004Enzyme electrodes mediator-assisted

Abstract

Apparatus and method are provided for determining the concentration of an analyte in a fluid test sample by applying the fluid test sample to the surface of a work- ing electrode which is electrochemically connected to a reference electrode which surface bears a composition comprising an enzyme specific for the analyte. A media- tor is reduced in response to a reaction between the ana- lyte and the enzyme. An oxidizing potential is applied between the electrodes to return at least a portion of the mediator back to its oxidized form before determining the concentration of the analyte to thereby increase the accuracy of the analyte determination. Following this initially applied potential, the circuit is switched to an open circuit or to a potential that substantially re- duces the current to minimize the rate of electrochemical potential at the working electrode. A second potential is applied between the electrodes and the current gener- ated in the fluid test sample is measured to determine analyte concentration. Optionally, the accuracy of the analyte determination is further enhanced algorithmi- cally.
CA002170660A 1995-05-05 1996-02-29 Method and apparatus for reduction of bias in amperometric sensors Expired - Lifetime CA2170660C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002416606A CA2416606C (en) 1995-05-05 1996-02-29 Apparatus and method for reduction of bias in amperometric sensors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/435,993 1995-05-05
US08/435,993 US5620579A (en) 1995-05-05 1995-05-05 Apparatus for reduction of bias in amperometric sensors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002416606A Division CA2416606C (en) 1995-05-05 1996-02-29 Apparatus and method for reduction of bias in amperometric sensors

Publications (2)

Publication Number Publication Date
CA2170660A1 true CA2170660A1 (en) 1996-11-06
CA2170660C CA2170660C (en) 2004-06-08

Family

ID=23730666

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002170660A Expired - Lifetime CA2170660C (en) 1995-05-05 1996-02-29 Method and apparatus for reduction of bias in amperometric sensors

Country Status (9)

Country Link
US (2) US5620579A (en)
EP (1) EP0741186B1 (en)
JP (1) JP3413323B2 (en)
AT (1) ATE207113T1 (en)
AU (1) AU701303B2 (en)
CA (1) CA2170660C (en)
DE (1) DE69615909T2 (en)
DK (1) DK0741186T3 (en)
ES (1) ES2162643T3 (en)

Families Citing this family (269)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM506894A0 (en) * 1994-04-14 1994-05-05 Memtec Limited Novel electrochemical cells
AUPN239395A0 (en) * 1995-04-12 1995-05-11 Memtec Limited Method of defining an electrode area
AUPN363995A0 (en) 1995-06-19 1995-07-13 Memtec Limited Electrochemical cell
US6413410B1 (en) 1996-06-19 2002-07-02 Lifescan, Inc. Electrochemical cell
AUPN661995A0 (en) * 1995-11-16 1995-12-07 Memtec America Corporation Electrochemical cell 2
US6638415B1 (en) 1995-11-16 2003-10-28 Lifescan, Inc. Antioxidant sensor
US6863801B2 (en) * 1995-11-16 2005-03-08 Lifescan, Inc. Electrochemical cell
US6521110B1 (en) 1995-11-16 2003-02-18 Lifescan, Inc. Electrochemical cell
US6632349B1 (en) 1996-11-15 2003-10-14 Lifescan, Inc. Hemoglobin sensor
EP0958495B1 (en) * 1997-02-06 2002-11-13 Therasense, Inc. Small volume in vitro analyte sensor
US6558321B1 (en) 1997-03-04 2003-05-06 Dexcom, Inc. Systems and methods for remote monitoring and modulation of medical devices
US20050033132A1 (en) 1997-03-04 2005-02-10 Shults Mark C. Analyte measuring device
US6741877B1 (en) 1997-03-04 2004-05-25 Dexcom, Inc. Device and method for determining analyte levels
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US7192450B2 (en) 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
AUPO855897A0 (en) 1997-08-13 1997-09-04 Usf Filtration And Separations Group Inc. Automatic analysing apparatus II
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
EP2085779B1 (en) * 1997-12-22 2017-11-01 Roche Diagnostics Operations, Inc. Meter
US7494816B2 (en) * 1997-12-22 2009-02-24 Roche Diagnostic Operations, Inc. System and method for determining a temperature during analyte measurement
US8071384B2 (en) 1997-12-22 2011-12-06 Roche Diagnostics Operations, Inc. Control and calibration solutions and methods for their use
US6475360B1 (en) 1998-03-12 2002-11-05 Lifescan, Inc. Heated electrochemical cell
US6878251B2 (en) * 1998-03-12 2005-04-12 Lifescan, Inc. Heated electrochemical cell
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
JP4256588B2 (en) 1998-05-20 2009-04-22 アークレイ株式会社 Electrochemical measurement method and measurement apparatus using statistical methods
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
DE19851164C2 (en) * 1998-11-06 2003-04-10 Draeger Safety Ag & Co Kgaa Method and device for operating an electrochemical measuring cell
CA2305922C (en) * 1999-08-02 2005-09-20 Bayer Corporation Improved electrochemical sensor design
US6841052B2 (en) 1999-08-02 2005-01-11 Bayer Corporation Electrochemical-sensor design
US20050103624A1 (en) * 1999-10-04 2005-05-19 Bhullar Raghbir S. Biosensor and method of making
JP4050434B2 (en) * 1999-11-29 2008-02-20 松下電器産業株式会社 Sample discrimination method
US6931388B2 (en) * 2000-02-09 2005-08-16 M.A.I.L., Inc. Accepting query that includes at least a portion of address without shipping identifier for tracking, delivery of shipment in computer network
KR100340173B1 (en) * 2000-03-22 2002-06-12 이동준 Electrochemical Biosensor Readout Meter
US6444115B1 (en) 2000-07-14 2002-09-03 Lifescan, Inc. Electrochemical method for measuring chemical reaction rates
RU2278612C2 (en) 2000-07-14 2006-06-27 Лайфскен, Инк. Immune sensor
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
JP4639465B2 (en) * 2000-11-30 2011-02-23 パナソニック株式会社 Biosensor
EP2096435B1 (en) * 2000-11-30 2014-11-12 Panasonic Healthcare Co., Ltd. Method of quantifying substrate
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US7351323B2 (en) * 2001-01-17 2008-04-01 Arkray, Inc. Quantitative analyzing method and quantitative analyzer using sensor
US7041468B2 (en) 2001-04-02 2006-05-09 Therasense, Inc. Blood glucose tracking apparatus and methods
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
ATE485766T1 (en) 2001-06-12 2010-11-15 Pelikan Technologies Inc ELECTRICAL ACTUATING ELEMENT FOR A LANCET
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CA2448905C (en) 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Blood sampling apparatus and method
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
ATE497731T1 (en) 2001-06-12 2011-02-15 Pelikan Technologies Inc DEVICE FOR INCREASING THE SUCCESS RATE OF BLOOD YIELD OBTAINED BY A FINGER PICK
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
AU2002300223B2 (en) * 2001-08-13 2008-12-11 Bayer Corporation Mechanical Mechanism for a Blood Glucose Sensor Dispensing Instrument
US7323141B2 (en) * 2001-08-13 2008-01-29 Bayer Healthcare Llc Button layout for a testing instrument
US7723113B2 (en) * 2001-08-20 2010-05-25 Bayer Healthcare Llc Packaging system for test sensors
USRE44522E1 (en) 2001-09-14 2013-10-08 Arkray, Inc. Concentration measuring method, concentration test instrument, and concentration measuring apparatus
IL156007A0 (en) * 2001-10-10 2003-12-23 Lifescan Inc Electrochemical cell
EP1447660B1 (en) * 2001-10-26 2007-03-21 Arkray, Inc. Specific component concentration measuring method and concentration measuring instrument
ATE479089T1 (en) * 2001-11-16 2010-09-15 Stefan Ufer FLEXIBLE SENSOR AND MANUFACTURING METHOD
CN1271405C (en) 2001-11-20 2006-08-23 爱科来株式会社 Fail judging method and analyzer
US6863800B2 (en) * 2002-02-01 2005-03-08 Abbott Laboratories Electrochemical biosensor strip for analysis of liquid samples
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US20060134713A1 (en) 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US6743635B2 (en) * 2002-04-25 2004-06-01 Home Diagnostics, Inc. System and methods for blood glucose sensing
US7226978B2 (en) 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
EP2149792B1 (en) * 2002-07-25 2017-01-25 ARKRAY, Inc. Sample analyzing method
US7399401B2 (en) * 2002-10-09 2008-07-15 Abbott Diabetes Care, Inc. Methods for use in assessing a flow condition of a fluid
US7175897B2 (en) * 2002-12-17 2007-02-13 Avery Dennison Corporation Adhesive articles which contain at least one hydrophilic or hydrophobic layer, method for making and uses for same
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7132041B2 (en) * 2003-02-11 2006-11-07 Bayer Healthcare Llc Methods of determining the concentration of an analyte in a fluid test sample
US7134999B2 (en) 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
US7679407B2 (en) * 2003-04-28 2010-03-16 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
US7875293B2 (en) 2003-05-21 2011-01-25 Dexcom, Inc. Biointerface membranes incorporating bioactive agents
ATE476137T1 (en) 2003-05-30 2010-08-15 Pelikan Technologies Inc METHOD AND DEVICE FOR INJECTING LIQUID
WO2004107964A2 (en) 2003-06-06 2004-12-16 Pelikan Technologies, Inc. Blood harvesting device with electronic control
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
ES2681398T3 (en) * 2003-06-20 2018-09-12 F. Hoffmann-La Roche Ag Test strip with widened sample reception chamber
US8206565B2 (en) 2003-06-20 2012-06-26 Roche Diagnostics Operation, Inc. System and method for coding information on a biosensor test strip
US7718439B2 (en) 2003-06-20 2010-05-18 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US7645373B2 (en) 2003-06-20 2010-01-12 Roche Diagnostic Operations, Inc. System and method for coding information on a biosensor test strip
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US7645421B2 (en) 2003-06-20 2010-01-12 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US8071030B2 (en) 2003-06-20 2011-12-06 Roche Diagnostics Operations, Inc. Test strip with flared sample receiving chamber
US8679853B2 (en) * 2003-06-20 2014-03-25 Roche Diagnostics Operations, Inc. Biosensor with laser-sealed capillary space and method of making
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US7366556B2 (en) 2003-12-05 2008-04-29 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
WO2005012873A2 (en) 2003-07-25 2005-02-10 Dexcom, Inc. Electrode systems for electrochemical sensors
US7108778B2 (en) * 2003-07-25 2006-09-19 Dexcom, Inc. Electrochemical sensors including electrode systems with increased oxygen generation
US7467003B2 (en) * 2003-12-05 2008-12-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7424318B2 (en) 2003-12-05 2008-09-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
US7460898B2 (en) * 2003-12-05 2008-12-02 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US7494465B2 (en) 2004-07-13 2009-02-24 Dexcom, Inc. Transcutaneous analyte sensor
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US20100168543A1 (en) 2003-08-01 2010-07-01 Dexcom, Inc. System and methods for processing analyte sensor data
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US7986986B2 (en) 2003-08-01 2011-07-26 Dexcom, Inc. System and methods for processing analyte sensor data
US8060173B2 (en) 2003-08-01 2011-11-15 Dexcom, Inc. System and methods for processing analyte sensor data
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
WO2005018443A1 (en) * 2003-08-15 2005-03-03 Animas Technologies Llc Microprocessors, devices, and methods for use in monitoring of physiological analytes
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US7547381B2 (en) * 2003-09-26 2009-06-16 Agency For Science, Technology And Research And National University Of Singapore Sensor array integrated electrochemical chip, method of forming same, and electrode coating
EP1671096A4 (en) 2003-09-29 2009-09-16 Pelikan Technologies Inc Method and apparatus for an improved sample capture device
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
CA2543010A1 (en) 2003-10-24 2005-05-06 Bayer Healthcare Llc Enzymatic electrochemical biosensor
WO2005051170A2 (en) 2003-11-19 2005-06-09 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8287453B2 (en) 2003-12-05 2012-10-16 Dexcom, Inc. Analyte sensor
EP2239567B1 (en) 2003-12-05 2015-09-02 DexCom, Inc. Calibration techniques for a continuous analyte sensor
EP2329763B1 (en) 2003-12-09 2017-06-21 DexCom, Inc. Signal processing for continuous analyte sensor
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
JP4814110B2 (en) 2004-02-06 2011-11-16 バイエル・ヘルスケア・エルエルシー Electrochemical biosensor
BRPI0507376A (en) * 2004-02-06 2007-07-10 Bayer Healthcare Llc oxidizable species as an internal reference for biosensors and method of use
US7807043B2 (en) * 2004-02-23 2010-10-05 Oakville Hong Kong Company Limited Microfluidic test device
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
TWI292041B (en) * 2004-03-03 2008-01-01 Apex Biotechnology Corp Method for reducing measuring bias in amperometric biosensors
CN100370249C (en) * 2004-03-04 2008-02-20 五鼎生物技术股份有限公司 Method for reducing measurement deviation of current type biosensors
US20070135697A1 (en) * 2004-04-19 2007-06-14 Therasense, Inc. Method and apparatus for providing sensor guard for data monitoring and detection systems
CN1981192B (en) 2004-05-14 2014-04-16 拜尔健康护理有限责任公司 Voltammetric systems for assaying biological analytes
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
TW200617389A (en) * 2004-06-17 2006-06-01 Bayer Healthcare Llc Sensor-dispensing instrument and method of using the same
WO2006007451A1 (en) * 2004-06-17 2006-01-19 Bayer Healthcare Llc Detecting incomplete fill of biosensors
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US7310544B2 (en) 2004-07-13 2007-12-18 Dexcom, Inc. Methods and systems for inserting a transcutaneous analyte sensor
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US7857760B2 (en) 2004-07-13 2010-12-28 Dexcom, Inc. Analyte sensor
EP1828769B1 (en) * 2004-08-20 2011-10-26 Bayer HealthCare, LLC Contact connector assembly for a sensor-dispensing instrument
WO2006042304A1 (en) * 2004-10-12 2006-04-20 Bayer Healthcare Llc Concentration determination in a diffusion barrier layer
CN101076728A (en) * 2004-12-13 2007-11-21 拜尔保健有限公司 A method of differentiating between blood and control solutions containing a common analyte
DE102004062051B4 (en) * 2004-12-23 2011-07-14 Dräger Safety AG & Co. KGaA, 23560 Method for determining the concentration of a gas with an electrochemical gas sensor
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
CN102778487B (en) 2005-04-08 2015-02-18 拜尔保健有限公司 Oxidizable species as an internal reference in control solutions for biosensors
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
WO2006130577A2 (en) * 2005-06-01 2006-12-07 Bayer Healthcare Llc Multi-contact sensor connector with release mechanism
EP1896840A1 (en) * 2005-06-29 2008-03-12 Oxford Biosensors Limited Electrode preconditioning
AU2006272909B2 (en) * 2005-07-20 2013-02-07 Bayer Healthcare Llc Gated amperometry
KR101477815B1 (en) 2005-09-30 2015-01-02 바이엘 헬스케어 엘엘씨 Gated voltammetry
US7583190B2 (en) * 2005-10-31 2009-09-01 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
EP1991112A1 (en) * 2006-02-27 2008-11-19 Bayer Healthcare, LLC Temperature-adjusted analyte determination for biosensor systems
EP1991110B1 (en) 2006-03-09 2018-11-07 DexCom, Inc. Systems and methods for processing analyte sensor data
US8529751B2 (en) 2006-03-31 2013-09-10 Lifescan, Inc. Systems and methods for discriminating control solution from a physiological sample
US8038859B2 (en) * 2006-04-28 2011-10-18 Hmd Biomedical Inc. Electrochemical sensor and method for analyzing liquid sample
US7966859B2 (en) * 2006-05-03 2011-06-28 Bayer Healthcare Llc Underfill detection system for a biosensor
WO2007131036A1 (en) * 2006-05-03 2007-11-15 Bayer Healthcare Llc Underfill detection system for an electrochemical biosensor
WO2007133985A2 (en) 2006-05-08 2007-11-22 Bayer Healthcare Llc Abnormal output detection system for a biosensor
EP1860432B1 (en) * 2006-05-24 2017-12-13 Bionime GmbH A method for operating a measuring meter and a measuring meter
US20080071158A1 (en) 2006-06-07 2008-03-20 Abbott Diabetes Care, Inc. Analyte monitoring system and method
JP5056755B2 (en) * 2006-07-26 2012-10-24 パナソニック株式会社 Biosensor measurement system and abnormal waveform detection method in biosensor
US8945369B2 (en) 2006-07-26 2015-02-03 Panasonic Healthcare Co., Ltd. Biosensor measurement system and measurement method
RU2009107211A (en) * 2006-07-31 2010-09-10 Байер Хелткэр Ллк (Us) PACKING SYSTEM FOR TESTING DEVICES
DE102006043718B4 (en) * 2006-09-18 2014-12-31 Alexander Adlassnig Determination of hydrogen peroxide concentrations
EP3543348B1 (en) 2006-09-22 2020-11-18 Ascensia Diabetes Care Holdings AG Biosensor system having enhanced stability and hematocrit performance
JP4582076B2 (en) * 2006-10-03 2010-11-17 パナソニック株式会社 Substrate quantification method
US7831287B2 (en) 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
BRPI0717620A2 (en) 2006-10-24 2013-10-22 Bayer Healthcare Llc TRANSITIONAL DECAY AMPEROMETRY
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
EP2152350A4 (en) 2007-06-08 2013-03-27 Dexcom Inc Integrated medicament delivery device for use with continuous analyte sensor
EP3660499A1 (en) 2007-09-24 2020-06-03 Ascensia Diabetes Care Holdings AG Multi-electrode test sensor
US8778168B2 (en) * 2007-09-28 2014-07-15 Lifescan, Inc. Systems and methods of discriminating control solution from a physiological sample
EP2227132B1 (en) 2007-10-09 2023-03-08 DexCom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
JP4985340B2 (en) * 2007-11-15 2012-07-25 住友電気工業株式会社 Biosensor system and measuring instrument
JP2009121996A (en) * 2007-11-15 2009-06-04 Sumitomo Electric Ind Ltd Biosensor system and measuring instrument therefor
CN101999073B (en) * 2007-12-10 2013-12-18 拜尔健康护理有限责任公司 Slope-based compensation
JP5455924B2 (en) 2007-12-10 2014-03-26 バイエル・ヘルスケア・エルエルシー Speed reading gate amperometry
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
EP2232250A1 (en) * 2007-12-10 2010-09-29 Bayer HealthCare LLC Methods and systems for forming reagent with reduced background current
US20090145775A1 (en) 2007-12-10 2009-06-11 Bayer Healthcare Llc Reagents and methods for detecting analytes
JP4992693B2 (en) * 2007-12-12 2012-08-08 住友電気工業株式会社 Biological information measuring device
US8097674B2 (en) * 2007-12-31 2012-01-17 Bridgestone Corporation Amino alkoxy-modified silsesquioxanes in silica-filled rubber with low volatile organic chemical evolution
US8603768B2 (en) 2008-01-17 2013-12-10 Lifescan, Inc. System and method for measuring an analyte in a sample
US20090208734A1 (en) * 2008-01-18 2009-08-20 Macfie Gavin Test strips, methods, and system of manufacturing test strip lots having a predetermined calibration characteristic
EP2265324B1 (en) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Integrated analyte measurement system
US20090305317A1 (en) * 2008-06-05 2009-12-10 Brauer Jacob S User interface for testing device
US8551320B2 (en) * 2008-06-09 2013-10-08 Lifescan, Inc. System and method for measuring an analyte in a sample
US8262899B2 (en) 2008-07-10 2012-09-11 Bayer Healthcare Llc Systems and methods including amperometric and voltammetric duty cycles
WO2010077660A1 (en) 2008-12-08 2010-07-08 Bayer Healthcare Llc Biosensor system with signal adjustment
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
WO2010111660A1 (en) 2009-03-27 2010-09-30 Dexcom, Inc. Methods and systems for promoting glucose management
US20120181173A1 (en) 2009-07-30 2012-07-19 Fundacion Cidetec Electrochemical sensor for the detection of analytes in liquid media
EP2499483B1 (en) * 2009-11-10 2021-03-17 Ascensia Diabetes Care Holdings AG Method and biosensor for assessing the volume of a blood sample
US8101065B2 (en) 2009-12-30 2012-01-24 Lifescan, Inc. Systems, devices, and methods for improving accuracy of biosensors using fill time
US8877034B2 (en) * 2009-12-30 2014-11-04 Lifescan, Inc. Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity
WO2011091363A2 (en) * 2010-01-22 2011-07-28 Bayer Healthcare Llc Accuracy improving desiccants
CA2692097A1 (en) 2010-02-04 2011-08-04 Ignis Innovation Inc. Extracting correlation curves for light emitting device
RU2568884C2 (en) 2010-03-22 2015-11-20 БАЙЕР ХЕЛТКЭА ЭлЭлСи Compensation of discrepancy for biosensor
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
JP4840521B2 (en) * 2010-04-27 2011-12-21 パナソニック株式会社 Biosensor, biosensor measuring apparatus, and substrate quantification method
JP4840520B2 (en) * 2010-04-27 2011-12-21 パナソニック株式会社 Biosensor, biosensor measuring apparatus, and substrate quantification method
CN104502426B (en) 2010-06-07 2017-05-10 安晟信医疗科技控股公司 Underfill Management System For Biosensor
ES2700100T3 (en) 2010-06-07 2019-02-14 Ascensia Diabetes Care Holding Ag Compensation based on slope including secondary output signals
US8932445B2 (en) 2010-09-30 2015-01-13 Cilag Gmbh International Systems and methods for improved stability of electrochemical sensors
US8617370B2 (en) 2010-09-30 2013-12-31 Cilag Gmbh International Systems and methods of discriminating between a control sample and a test fluid using capacitance
WO2012142502A2 (en) 2011-04-15 2012-10-18 Dexcom Inc. Advanced analyte sensor calibration and error detection
CN103392127B (en) * 2011-05-10 2016-05-04 松下健康医疗控股株式会社 Organism sample determinator and the organism sample assay method that uses it
TWI427291B (en) * 2011-07-06 2014-02-21 Bionime Corp Method for operating a measurement of a sample on an electrochemical test strip
JP6082396B2 (en) 2011-09-21 2017-02-15 バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC Biosensor with error compensation
US9572922B2 (en) 2012-12-21 2017-02-21 Larry Leonard Inventive diabetic systems, tools, kits, and supplies for better diabetic living and mobility
JP5775967B2 (en) * 2012-04-19 2015-09-09 パナソニックヘルスケアホールディングス株式会社 Biological information measuring apparatus and biological information measuring method using the same
TWI547687B (en) * 2012-06-13 2016-09-01 達爾生技股份有限公司 Calibration method for blood glucose of blood sample and calibration system of the same
US9201038B2 (en) * 2012-07-24 2015-12-01 Lifescan Scotland Limited System and methods to account for interferents in a glucose biosensor
US9080196B2 (en) * 2012-09-28 2015-07-14 Cilag Gmbh International System and method for determining hematocrit insensitive glucose concentration
US9005426B2 (en) * 2012-09-28 2015-04-14 Cilag Gmbh International System and method for determining hematocrit insensitive glucose concentration
JP6055847B2 (en) * 2013-01-23 2016-12-27 株式会社日立ハイテクノロジーズ Electrochemical measuring device
US20140209481A1 (en) * 2013-01-25 2014-07-31 Google Inc. Standby Biasing Of Electrochemical Sensor To Reduce Sensor Stabilization Time During Measurement
EP2972396A1 (en) 2013-03-14 2016-01-20 Bayer HealthCare LLC Normalized calibration of analyte concentration determinations
ES2715407T3 (en) 2013-03-14 2019-06-04 Ascensia Diabetes Care Holdings Ag Progressive approach to the concentration of a sample analyte
WO2014159333A1 (en) 2013-03-14 2014-10-02 Bayer Healthcare Llc System error compensation of analyte concentration determinations
US10823715B2 (en) * 2017-07-19 2020-11-03 American Sterilizer Company Chemical indicator for monitoring hydrogen peroxide sterilization and disinfection processes
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
CA3077720A1 (en) 2017-10-24 2019-05-02 Dexcom, Inc. Pre-connected analyte sensors
US20190178832A1 (en) * 2017-12-07 2019-06-13 Pinnacle Bio, LLC Portable microbial load detection

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57179655A (en) * 1981-04-30 1982-11-05 Fuji Electric Co Ltd Compensating method for background in quantification of composite constituent wherein enzyme electrode is used
DE3228551A1 (en) * 1982-07-30 1984-02-02 Siemens AG, 1000 Berlin und 8000 München METHOD FOR DETERMINING SUGAR CONCENTRATION
US4496454A (en) * 1983-10-19 1985-01-29 Hewlett-Packard Company Self cleaning electrochemical detector and cell for flowing stream analysis
DE3429583A1 (en) * 1984-08-10 1986-02-20 Siemens AG, 1000 Berlin und 8000 München METHOD FOR ELECTROCHEMICALLY DETERMINING THE OXYGEN CONCENTRATION
US4746607A (en) * 1985-02-07 1988-05-24 Eastman Kodak Company Use of substituted quinone electron transfer agents in analytical determinations
US5126247A (en) * 1988-02-26 1992-06-30 Enzymatics, Inc. Method, system and devices for the assay and detection of biochemical molecules
GB8811860D0 (en) * 1988-05-19 1988-06-22 Emi Plc Thorn Amperometric measurement of metabolites
DE3826922A1 (en) * 1988-08-09 1990-02-22 Boehringer Mannheim Gmbh PROCESS FOR THE COLOR-RIMETRIC DETERMINATION OF AN ANALYTE BY ENZYMATIC OXIDATION
US4929545A (en) * 1989-04-14 1990-05-29 Boehringer Mannheim Corporation Method and reagent for determination of an analyte via enzymatic means using a ferricyanide/ferric compound system
AU634863B2 (en) * 1989-12-15 1993-03-04 Roche Diagnostics Operations Inc. Redox mediator reagent and biosensor
US5288387A (en) * 1990-06-12 1994-02-22 Daikin Industries, Ltd. Apparatus for maintaining the activity of an enzyme electrode
US5112455A (en) * 1990-07-20 1992-05-12 I Stat Corporation Method for analytically utilizing microfabricated sensors during wet-up
JPH06313760A (en) * 1993-04-30 1994-11-08 Kyoto Daiichi Kagaku:Kk Method for measuring specimen by enzyme electrode
GB9318677D0 (en) * 1993-09-09 1993-10-27 Kodak Ltd Method and apparatus for measuring silver ion activity

Also Published As

Publication number Publication date
EP0741186B1 (en) 2001-10-17
DE69615909T2 (en) 2002-04-04
JP3413323B2 (en) 2003-06-03
JPH08304340A (en) 1996-11-22
ATE207113T1 (en) 2001-11-15
EP0741186A2 (en) 1996-11-06
US5653863A (en) 1997-08-05
CA2170660C (en) 2004-06-08
EP0741186A3 (en) 1998-05-13
AU5205896A (en) 1996-11-14
AU701303B2 (en) 1999-01-21
ES2162643T3 (en) 2002-01-01
DK0741186T3 (en) 2002-01-14
DE69615909D1 (en) 2001-11-22
US5620579A (en) 1997-04-15

Similar Documents

Publication Publication Date Title
CA2170660A1 (en) Method and apparatus for reduction of bias in amperometric sensors
CA2167822A1 (en) Potentiometric biosensor and the method for its use
CA2300406A1 (en) Method and apparatus for automatic analysis
EP0415393B1 (en) Method and apparatus for reviving an electrode of a biosensor
CA2573423C (en) Electrochemical cell
CN100409008C (en) Electrochemical process
US6413410B1 (en) Electrochemical cell
EP0255291B1 (en) Method and apparatus for electrochemical measurements
AU6157898A (en) Small volume (in vitro) analyte sensor
CA2140903A1 (en) Biosensor for hematocrit determination
CA2069946A1 (en) Redox mediator reagent and biosensor
AU2003239672A1 (en) Analyte measurement
AU1647697A (en) Control solution and method for testing the performance of an electrochemical device for determining the concentration of an analyte in blood
AU4215799A (en) Method and device for electrochemical immunoassay of multiple analytes
EP0909952A3 (en) Biosensor and method for quantitative measurement of a substrate using the same
JP2005526260A5 (en)
CA2346415A1 (en) Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
EP1873255A3 (en) Electrode with thin working layer
Sun et al. Determination of allopurinol and its active metabolite oxypurinol by capillary electrophoresis with end-column amperometric detection
CA2416606A1 (en) Apparatus and method for reduction of bias in amperometric sensors
Jin et al. A study of uricase biosensor based on a glassy carbon electrode modified with Nafion and methyl viologen
EP0264210A3 (en) Chemical probe and enzyme sensor therefor
AU735132B2 (en) Electrochemical cell

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20160229

MKEX Expiry

Effective date: 20160229