CA2169191A1 - Neural regeneration using human bone morphogenetic proteins - Google Patents

Neural regeneration using human bone morphogenetic proteins

Info

Publication number
CA2169191A1
CA2169191A1 CA002169191A CA2169191A CA2169191A1 CA 2169191 A1 CA2169191 A1 CA 2169191A1 CA 002169191 A CA002169191 A CA 002169191A CA 2169191 A CA2169191 A CA 2169191A CA 2169191 A1 CA2169191 A1 CA 2169191A1
Authority
CA
Canada
Prior art keywords
bone morphogenetic
neural
human bone
morphogenetic proteins
neural regeneration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002169191A
Other languages
French (fr)
Other versions
CA2169191C (en
Inventor
Elizabeth A. Wang
Josephine S. D'alessandro
Dean Toriumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
University of Illinois
Original Assignee
Elizabeth A. Wang
Josephine S. D'alessandro
Dean Toriumi
Genetics Institute, Inc.
Board Of Trustees Of The University Of Illinois (The)
Genetics Institute, Llc
The Board Of Trustees Of The University Of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elizabeth A. Wang, Josephine S. D'alessandro, Dean Toriumi, Genetics Institute, Inc., Board Of Trustees Of The University Of Illinois (The), Genetics Institute, Llc, The Board Of Trustees Of The University Of Illinois filed Critical Elizabeth A. Wang
Publication of CA2169191A1 publication Critical patent/CA2169191A1/en
Application granted granted Critical
Publication of CA2169191C publication Critical patent/CA2169191C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction

Abstract

Methods and devices are disclosed for inducing growth of neural cells, and repairing neural defects in a mammal. The method comprises administering to said mammal at the site of neural defect, damage or depletion, an effective amount of a bone morphogenetic protein, either in admixture with a pharmaceutically acceptable vehicle, or adsorbed to a suitable matrix. The device comprises bone morphogenetic protein, optionally in combination with other factors, adsorbed on a suitable matrix and contained within an artificial nerve replacement vessel.
CA002169191A 1993-08-26 1994-08-19 Neural regeneration using human bone morphogenetic proteins Expired - Lifetime CA2169191C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11249293A 1993-08-26 1993-08-26
US08/112,492 1993-08-26
PCT/US1994/009330 WO1995005846A1 (en) 1993-08-26 1994-08-19 Neural regeneration using human bone morphogenetic proteins

Publications (2)

Publication Number Publication Date
CA2169191A1 true CA2169191A1 (en) 1995-03-02
CA2169191C CA2169191C (en) 2008-01-15

Family

ID=22344181

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002169191A Expired - Lifetime CA2169191C (en) 1993-08-26 1994-08-19 Neural regeneration using human bone morphogenetic proteins

Country Status (15)

Country Link
US (1) US5756457A (en)
EP (2) EP1716864A1 (en)
JP (3) JPH09501932A (en)
KR (2) KR100329409B1 (en)
AT (1) ATE326234T1 (en)
AU (1) AU677866B2 (en)
CA (1) CA2169191C (en)
DE (1) DE69434739T2 (en)
DK (1) DK0716610T3 (en)
ES (1) ES2265146T3 (en)
FI (1) FI960809A0 (en)
NO (1) NO960711D0 (en)
OA (1) OA10358A (en)
PT (1) PT716610E (en)
WO (1) WO1995005846A1 (en)

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