CA2167586A1 - Needle-less injector - Google Patents

Needle-less injector

Info

Publication number
CA2167586A1
CA2167586A1 CA002167586A CA2167586A CA2167586A1 CA 2167586 A1 CA2167586 A1 CA 2167586A1 CA 002167586 A CA002167586 A CA 002167586A CA 2167586 A CA2167586 A CA 2167586A CA 2167586 A1 CA2167586 A1 CA 2167586A1
Authority
CA
Canada
Prior art keywords
cartridge
needle
less injector
piston
injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002167586A
Other languages
French (fr)
Other versions
CA2167586C (en
Inventor
Terence Edward Weston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zogenix Inc
Original Assignee
Terence Edward Weston
Weston Medical Limited
Aradigm Corporation
Sj2 Therapeutics, Inc.
Zogenix, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939315915A external-priority patent/GB9315915D0/en
Application filed by Terence Edward Weston, Weston Medical Limited, Aradigm Corporation, Sj2 Therapeutics, Inc., Zogenix, Inc. filed Critical Terence Edward Weston
Publication of CA2167586A1 publication Critical patent/CA2167586A1/en
Application granted granted Critical
Publication of CA2167586C publication Critical patent/CA2167586C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Abstract

A needle-less injector comprises a cartridge (3) prefilled with liquid (9), which cartridge contains a free sliding piston (32) and an injection orifice (10). A ram (22) is urged by a pre-loaded spring (24) for striking the said piston to cause the injections. Adjusting means (6) can be provided to vary the volume injected. A trigger device (26, 30) initiates injection only when the optimum contact pressure is reached between the discharge orifice (1) and epidermis of the subject. The initial loading of the power spring (24) is sufficient to dispense all of the contents of the medicament cartridge in one dose or multiple sequential doses. Disposable and reusable embodiments are described.
CA002167586A 1993-07-31 1994-07-27 Needle-less injector Expired - Lifetime CA2167586C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB939315915A GB9315915D0 (en) 1993-07-31 1993-07-31 Needle-less injector
GB9315915.0 1993-07-31
GB939319981A GB9319981D0 (en) 1993-07-31 1993-09-28 Needle-less injector
GB9319981.8 1993-09-28
PCT/GB1994/001608 WO1995003844A1 (en) 1993-07-31 1994-07-27 Needle-less injector

Publications (2)

Publication Number Publication Date
CA2167586A1 true CA2167586A1 (en) 1995-02-09
CA2167586C CA2167586C (en) 2005-01-25

Family

ID=26303316

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002167586A Expired - Lifetime CA2167586C (en) 1993-07-31 1994-07-27 Needle-less injector

Country Status (15)

Country Link
US (3) US5891086A (en)
EP (3) EP0834330B1 (en)
JP (3) JP3487856B2 (en)
KR (2) KR100223616B1 (en)
AT (2) ATE197904T1 (en)
AU (1) AU7233194A (en)
BR (1) BR9407156A (en)
CA (1) CA2167586C (en)
DE (2) DE69433366T2 (en)
DK (1) DK0710130T3 (en)
ES (2) ES2212040T3 (en)
HK (1) HK1010697A1 (en)
NO (2) NO312011B1 (en)
RU (1) RU2179864C2 (en)
WO (1) WO1995003844A1 (en)

Families Citing this family (215)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6681810B2 (en) 1994-12-20 2004-01-27 Aradigm Corporation Filling device for a needleless injector cartridge
GB9425642D0 (en) 1994-12-20 1995-02-22 Weston Medical Ltd Filling device
WO1996024398A1 (en) * 1995-02-06 1996-08-15 Weston Medical Limited Needle-less injector
GB9504878D0 (en) * 1995-03-10 1995-04-26 Weston Medical Ltd Viscously coupled actuator
US5730723A (en) * 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US6474369B2 (en) 1995-05-26 2002-11-05 Penjet Corporation Apparatus and method for delivering a lyophilized active with a needle-less injector
US6223786B1 (en) 1998-11-14 2001-05-01 Pen Jet Corporation Apparatus and method for mixing medication and filling an ampule of a needle-less injector
FR2739562B1 (en) * 1995-10-09 1998-04-24 Moreau Defarges Alain JET INJECTION DEVICE WITHOUT NEEDLE, INCLUDING AN OVER-MOLDED CARTRIDGE
US6080130A (en) * 1998-11-14 2000-06-27 Castellano; Thomas P. Gas power source for a needle-less injector
GB9525757D0 (en) 1995-12-16 1996-02-14 Weston Medical Ltd Needleless injector drug capsule and filling method
US5782802A (en) * 1996-03-22 1998-07-21 Vitajet Corporation Multiple use needle-less hypodermic injection device for individual users
DK0892736T3 (en) 1996-04-02 2000-10-23 Weston Medical Ltd Method of filling a drug capsule and article thus produced
GB9607549D0 (en) * 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
FR2751228B1 (en) * 1996-07-19 1998-11-20 Rhone Merieux BOVINE POLYNUCLEOTIDE VACCINE FOR INTRADERMAL ROUTE
US5954689A (en) * 1996-12-20 1999-09-21 Novo Nordisk A/S Jet injector
US6770623B1 (en) * 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
WO2000006227A1 (en) * 1998-07-27 2000-02-10 Medi-Ject Corporation Loading mechanism for medical injector assembly
CN1651103A (en) 1998-07-27 2005-08-10 安塔雷斯药品公司 Injection device
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
GB9819962D0 (en) * 1998-09-15 1998-11-04 Weston Medical Ltd Needleless injection cartridge
US6506177B2 (en) * 1998-10-14 2003-01-14 Sergio Landau Needle-less injection system
US6406455B1 (en) * 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
DE19859137C1 (en) * 1998-12-21 2000-05-18 Ferton Holding Sa High pressure medicinal injection unit includes piston advanced into pressure chamber by series of resilient impacts, forcing fluid out in series of impulses for precise low-volume dosing
DE19913344C1 (en) 1999-03-24 2000-08-24 Deutscher Zahnarzt Verlag Dzv Needleless injection syringe includes mounting for capsule of medicament with piston operated by spring, which can be tensioned from common rotary unit
WO2000067825A1 (en) * 1999-05-07 2000-11-16 Microheart, Inc. Apparatus and method for delivering therapeutic and diagnostic agents
WO2000072908A1 (en) * 1999-06-02 2000-12-07 Microheart, Inc. Devices and methods for delivering a drug
US7147633B2 (en) * 1999-06-02 2006-12-12 Boston Scientific Scimed, Inc. Method and apparatus for treatment of atrial fibrillation
WO2001026717A1 (en) * 1999-10-11 2001-04-19 Needleless Ventures, Inc. Universal anti-infectious protector for needleless injectors
DE19955201A1 (en) * 1999-11-16 2001-05-31 Roesch Ag Medizintechnik Injection device
US7887506B1 (en) 1999-11-23 2011-02-15 Pulse Needlefree Systems, Inc. Safety mechanism to prevent accidental patient injection and methods of same
FR2802102B1 (en) * 1999-12-08 2002-07-12 Poudres & Explosifs Ste Nale NEEDLELESS SYRINGE WITH CONSTANT SECTION EJECTION TUBE
DK1242132T3 (en) * 1999-12-23 2004-02-23 Arnold Neracher Injection device and propulsion system therefore
WO2001051109A1 (en) † 2000-01-07 2001-07-19 Biovalve Technologies, Inc. Injection device
DE10010123A1 (en) 2000-03-03 2001-09-20 Boehringer Ingelheim Int Needle-less injector for liquids comprises a tensioning system, an energy storing spring, a hollow piston in a cylinder, and a nozzle
US6689092B2 (en) 2000-03-03 2004-02-10 Boehringer International Gmbh Needle-less injector of miniature type
US6558348B2 (en) * 2000-04-07 2003-05-06 Equidyne Systems, Inc. Low cost disposable needleless injector system for variable and fixed dose applications
US6716190B1 (en) * 2000-04-19 2004-04-06 Scimed Life Systems, Inc. Device and methods for the delivery and injection of therapeutic and diagnostic agents to a target site within a body
FR2809626B1 (en) * 2000-05-30 2003-03-07 Poudres & Explosifs Ste Nale NEEDLELESS SYRINGE WITH MULTI-DUCT EJECTOR INSULATION MEMBRANE
US6406456B1 (en) 2000-06-08 2002-06-18 Avant Drug Delivery Systems, Inc. Jet injector
DE10029325A1 (en) * 2000-06-20 2002-01-03 Peter Lell Needle-free injection device with pyrotechnic drive
FR2810554B1 (en) 2000-06-22 2003-05-16 Poudres & Explosifs Ste Nale SYRINGE WITHOUT NEEDLE PROVIDED WITH A MODULAR RESERVOIR
WO2002051470A2 (en) * 2000-11-30 2002-07-04 Biovalve Technologies, Inc. Injection systems
GB0103348D0 (en) * 2001-02-10 2001-03-28 Medical Res Council Delivery of biologically active agents
US20020172615A1 (en) * 2001-03-08 2002-11-21 Archie Woodworth Apparatus for and method of manufacturing a prefilled sterile container
US20020139088A1 (en) 2001-03-08 2002-10-03 Archie Woodworth Polymeric syringe body and stopper
JP2004529754A (en) 2001-03-14 2004-09-30 ペンジェット・コーポレーション System and method for removing dissolved gases from a solution
ATE299729T1 (en) * 2001-03-15 2005-08-15 Us Gov Health & Human Serv NEBULIZER WITH COOLING CHAMBER
US20050192530A1 (en) * 2001-04-13 2005-09-01 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
US6755220B2 (en) 2001-04-27 2004-06-29 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
DE10129583A1 (en) * 2001-06-20 2003-01-09 Disetronic Licensing Ag Device and method for injection
DE10129584B4 (en) * 2001-06-20 2007-06-28 Tecpharma Licensing Ag Tripping device for a Druckstrahlinjektor
US7235063B2 (en) * 2001-08-21 2007-06-26 D'antonio Consultants International, Inc. Hypodermic injection system
DE10143350A1 (en) * 2001-09-04 2003-03-20 Boehringer Ingelheim Int Locking mechanism for a miniaturized high pressure generator
US6945472B2 (en) * 2001-09-04 2005-09-20 Boehringer Ingelheim International Gmbh Locking-stressing mechanism for a miniaturised high pressuriser
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
GB0125506D0 (en) 2001-10-24 2001-12-12 Weston Medical Ltd Needle free injection method and apparatus
US6939323B2 (en) 2001-10-26 2005-09-06 Massachusetts Institute Of Technology Needleless injector
GB0127942D0 (en) 2001-11-21 2002-01-16 Weston Medical Ltd Needleless injector drug capsule and a method for filing thereof
JP3993169B2 (en) 2002-02-11 2007-10-17 アンタレス・ファーマ・インコーポレーテッド Intradermal syringe
GB0206560D0 (en) * 2002-03-20 2002-05-01 Glaxo Group Ltd Novel device
DE10223192A1 (en) * 2002-05-24 2003-12-11 Disetronic Licensing Ag Ampoule and delivery device
US6942638B1 (en) * 2002-05-30 2005-09-13 Kerry Quinn Needleless injector and ampule system
US6676630B2 (en) 2002-06-04 2004-01-13 Bioject Medical Technologies, Inc. Needle-free injection system
US7238167B2 (en) * 2002-06-04 2007-07-03 Bioject Inc. Needle-free injection system
US7156823B2 (en) * 2002-06-04 2007-01-02 Bioject Inc. High workload needle-free injection system
DK1515763T3 (en) * 2002-06-10 2011-11-21 Intervet Int Bv Needless injector
SE524714C2 (en) * 2002-06-28 2004-09-21 Asept Medical Ab Bone cement processor and applicator
EP3610909A1 (en) 2002-07-02 2020-02-19 PHC Holdings Corporation Automatic administration instrument for medical use
US7250037B2 (en) * 2002-07-22 2007-07-31 Becton, Dickinson And Company Patch-like infusion device
MXPA05002072A (en) 2002-08-26 2005-06-08 Penjet Corp Apparatus for needle-less injection with a degassed fluid.
US20040106894A1 (en) 2002-09-06 2004-06-03 Massachusetts Institute Of Technology Needleless drug injection device
US9486581B2 (en) * 2002-09-11 2016-11-08 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
US6883222B2 (en) * 2002-10-16 2005-04-26 Bioject Inc. Drug cartridge assembly and method of manufacture
GB0224505D0 (en) * 2002-10-22 2002-11-27 Medical House The Plc Needles injection device
US8162966B2 (en) * 2002-10-25 2012-04-24 Hydrocision, Inc. Surgical devices incorporating liquid jet assisted tissue manipulation and methods for their use
US10363061B2 (en) * 2002-10-25 2019-07-30 Hydrocision, Inc. Nozzle assemblies for liquid jet surgical instruments and surgical instruments for employing the nozzle assemblies
US6939319B1 (en) * 2002-11-20 2005-09-06 Conrad Anstead Process and device for single use, needle-free intradermal, subcutaneous, or intramuscular injections
DE10300052A1 (en) * 2003-01-03 2004-07-15 Tecpharma Licensing Ag Method and delivery system for providing an injectable delivery device
US20040158195A1 (en) * 2003-02-06 2004-08-12 Sibert Gary J. Needle-free mass injection device
US6935384B2 (en) * 2003-02-19 2005-08-30 Bioject Inc. Needle-free injection system
AU2004232858B2 (en) 2003-04-23 2009-07-09 Mannkind Corporation Hydraulically actuated pump for long duration medicament administration
WO2004112871A1 (en) * 2003-06-20 2004-12-29 Allergan, Inc. Needless injectors
FR2858303B1 (en) * 2003-07-31 2005-09-16 Persee Medica DEVICE AND METHOD FOR DELIVERING A FLUID
EP2609948B1 (en) * 2003-08-12 2020-01-08 Becton, Dickinson and Company Patch-like infusion device
US7442182B2 (en) 2003-10-24 2008-10-28 Bioject, Inc. Spring powered needle-free injection system
CA2546468C (en) * 2003-12-05 2015-05-26 Aradigm Corporation A device for readying a needle free injector for delivery
AU2004298717A1 (en) * 2003-12-18 2005-06-30 Novo Nordisk A/S Nozzle device with skin stretching means
US7328985B2 (en) * 2004-01-21 2008-02-12 Silverbrook Research Pty Ltd Inkjet printer cartridge refill dispenser with security mechanism
US7448734B2 (en) 2004-01-21 2008-11-11 Silverbrook Research Pty Ltd Inkjet printer cartridge with pagewidth printhead
US20050157112A1 (en) 2004-01-21 2005-07-21 Silverbrook Research Pty Ltd Inkjet printer cradle with shaped recess for receiving a printer cartridge
US7114289B2 (en) * 2004-02-23 2006-10-03 Bio Forest Technologies Inc. Apparatus for dispensing fluid into a tree
AU2005231716B2 (en) * 2004-03-31 2010-08-05 Izi Medical Products, Llc Apparatus for an improved high pressure medicinal dispenser
MXPA06011426A (en) * 2004-04-02 2007-04-20 Gov Health & Human Serv Aerosol delivery systems and methods.
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
DE102004042581B4 (en) 2004-09-02 2022-09-15 Ypsomed Ag Auto-Pen for dual-chamber ampoule
AU2012203600B2 (en) * 2004-09-10 2013-09-26 Becton, Dickinson And Company Reconstituting infusion device
ES2701090T3 (en) 2004-09-10 2019-02-20 Becton Dickinson Co Infusion reconstitution device and medicine reconstitution method
JP4904283B2 (en) 2004-12-01 2012-03-28 アキュショット インク Needleless syringe
DK1850892T4 (en) 2005-01-24 2023-06-06 Antares Pharma Inc Prefilled needle-assisted syringe injector
US7833189B2 (en) 2005-02-11 2010-11-16 Massachusetts Institute Of Technology Controlled needle-free transport
US7699802B2 (en) * 2005-05-03 2010-04-20 Pharmajet, Inc. Needle-less injector
US20070027428A1 (en) * 2005-05-03 2007-02-01 Pharmajet, Inc. Vial system and method for needle-less injector
US7618393B2 (en) 2005-05-03 2009-11-17 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US20080097291A1 (en) 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
US20070055199A1 (en) * 2005-08-10 2007-03-08 Gilbert Scott J Drug delivery device for buccal and aural applications and other areas of the body difficult to access
CA2629300C (en) * 2005-11-17 2014-07-08 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
US8480617B2 (en) * 2005-12-07 2013-07-09 Painless Tech Gmbh Injection device and ampoule unit
US20070185053A1 (en) * 2006-01-17 2007-08-09 Zogenix, Inc. Single-dose needle-free administration of antithrombotic medications
MX2008009464A (en) * 2006-01-23 2008-10-20 Yoshio Oyama An ampoule usable as a syringe and a syringe unit comprising the ampoule.
JP2007252551A (en) * 2006-03-23 2007-10-04 Shimadzu Corp Disk-like needleless syringe
JP2009532117A (en) 2006-03-30 2009-09-10 ヴァレリタス，エルエルシー Multi-cartridge fluid dispensing device
US8251947B2 (en) 2006-05-03 2012-08-28 Antares Pharma, Inc. Two-stage reconstituting injector
WO2007131025A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Injector with adjustable dosing
EP2029199B1 (en) * 2006-05-29 2015-07-08 Novo Nordisk A/S Mechanism for injection device
MX2008015462A (en) * 2006-06-07 2009-03-02 Acushot Inc Charging mechanism for a needle-free injector.
CN101500524A (en) * 2006-07-04 2009-08-05 大山义夫 End portion for hermetically sealed container having fine opening surface obtained easily by cleavage
US7771655B2 (en) * 2006-07-12 2010-08-10 Bayer Healthcare Llc Mechanical device for mixing a fluid sample with a treatment solution
ES2773842T3 (en) 2006-09-01 2020-07-15 Massachusetts Inst Technology Needle-free injector device with automatic loading capacity
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
US7780201B2 (en) * 2006-10-13 2010-08-24 Medela Holding Ag Tube connector with three part construction and latching component
DE102007004211A1 (en) 2007-01-27 2008-07-31 Lts Lohmann Therapie-Systeme Ag Disposable injector with at least one towing hook
DE102007008369A1 (en) * 2007-02-16 2008-08-21 Lts Lohmann Therapie-Systeme Ag Disposable injector with at least one central tie rod
US7744563B2 (en) * 2007-02-23 2010-06-29 Bioject, Inc. Needle-free injection devices and drug delivery systems therefor
DE102007018868A1 (en) * 2007-04-19 2008-10-23 Lts Lohmann Therapie-Systeme Ag Disposable injector with at least one towing hook and a sliding wedge gear for unlocking releasing a locking element
DE102007031714A1 (en) * 2007-07-06 2009-01-08 Lts Lohmann Therapie-Systeme Ag Disposable injector with at least one push rod and a cap
DE102007032464A1 (en) * 2007-07-10 2009-01-15 Lts Lohmann Therapie-Systeme Ag Disposable injector with at least one towing hook
GB2452030A (en) * 2007-08-10 2009-02-25 Owen Mumford Ltd Injection devices
CA2703393C (en) * 2007-11-02 2018-07-24 Talecris Biotherapeutics, Inc. Method, composition, and article of manufacture for providing alpha-1 antitrypsin
EP2214756A1 (en) * 2007-11-19 2010-08-11 Painless Tech GmbH Injection device for the needle-free injection of a medium
EP2085147B1 (en) * 2008-01-29 2012-04-04 Medmix Systems AG Device with pressure charged piston for dispensing a multiple syringe or multiple cartridge
US8814834B2 (en) 2008-03-10 2014-08-26 Antares Pharma, Inc. Injector safety device
ES2604968T3 (en) * 2008-04-28 2017-03-10 Zogenix, Inc. New formulations for the treatment of migraine
US8075517B2 (en) * 2008-06-11 2011-12-13 Shl Group Ab Medicament delivery device
US8398583B2 (en) 2008-07-09 2013-03-19 Massachusetts Institute Of Technology Method and apparatus for extraction of a sample from a sample source
EP2318075B1 (en) 2008-08-05 2019-05-22 Antares Pharma, Inc. Multiple dosage injector
EP2323718B1 (en) * 2008-08-06 2019-10-09 Perf-Action Technologies Ltd. Intradermal needle-less injection mechanism
DE102008037686B4 (en) * 2008-08-14 2012-07-05 Kettenbach Gmbh & Co. Kg Container and piston rod assembly and their use
EP2326370B1 (en) * 2008-09-18 2020-08-05 Becton, Dickinson and Company Medical injector with slidable sleeve activation
EP2331176B1 (en) * 2008-09-18 2020-10-28 Becton, Dickinson and Company Medical injector with rotatable body portions
DE102008048595A1 (en) 2008-09-23 2010-04-01 Lts Lohmann Therapie-Systeme Ag Disposable injector with high injection safety
DE202009019078U1 (en) * 2008-10-13 2016-04-12 Sanofi-Aventis Deutschland Gmbh Drug delivery device
EP2193817A1 (en) * 2008-12-02 2010-06-09 Sanofi-Aventis Deutschland GmbH Drive assembly suitable for use in a medication delivery device and medication delivery device
DE102008063517A1 (en) * 2008-12-18 2010-07-01 Lts Lohmann Therapie-Systeme Ag Disposable injector with a flexurally elastic housing II
DE102008063519A1 (en) * 2008-12-18 2010-07-01 Lts Lohmann Therapie-Systeme Ag Disposable injector with a flexurally elastic metal housing
DE102008063518A1 (en) * 2008-12-18 2010-07-01 Lts Lohmann Therapie-Systeme Ag Pumpable disposable injector with a flexurally elastic housing
WO2010085904A1 (en) * 2009-01-30 2010-08-05 Tecpharma Licensing Ag Administering device featuring plunger rod retraction
CA2755779C (en) 2009-03-20 2015-11-10 Antares Pharma, Inc. Hazardous agent injection system
AU2010239762B2 (en) * 2009-04-24 2012-08-02 Shl Group Ab Medicament delivery device
US8974423B2 (en) * 2009-06-01 2015-03-10 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
WO2011005971A1 (en) * 2009-07-09 2011-01-13 Cook Incorporated Spring action medical device
US9265461B2 (en) 2009-09-01 2016-02-23 Massachusetts Institute Of Technology Identification techniques and device for testing the efficacy of beauty care products and cosmetics
US8758271B2 (en) 2009-09-01 2014-06-24 Massachusetts Institute Of Technology Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties
JP2013506458A (en) * 2009-09-30 2013-02-28 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Drug delivery device, assembly for drug delivery device and method of assembling piston rod for drug delivery device
GB0918145D0 (en) * 2009-10-16 2009-12-02 Owen Mumford Ltd Injector apparatus
US20110143310A1 (en) 2009-12-15 2011-06-16 Hunter Ian W Lorentz-Force Actuated Cleaning Device
EP2512559B1 (en) 2009-12-16 2018-12-05 Becton, Dickinson and Company Self-injection device
US9833562B2 (en) 2009-12-16 2017-12-05 Becton, Dickinson And Company Self-injection device
US9277936B2 (en) * 2010-01-11 2016-03-08 Kenneth Finkelstein Surgical instrument having an integrated local anesthetic delivery system
AU2015203703B2 (en) * 2010-05-20 2018-01-18 Becton, Dickinson And Company Drug delivery device
CN102971027B (en) 2010-05-20 2015-08-26 贝克顿·迪金森公司 Drug delivery devices
JP5596476B2 (en) * 2010-09-13 2014-09-24 国立大学法人 新潟大学 Drive device for needleless syringe and drive method for drive device for needleless syringe
WO2012037268A2 (en) 2010-09-15 2012-03-22 Zogenix, Inc. Needle-free injectors and design parameters thereof that optimize injection performance
TWI459986B (en) * 2010-11-08 2014-11-11 Shl Group Ab Container holder assembly
TWI520756B (en) * 2010-11-19 2016-02-11 默沙東消費者保護公司 Method of using click pen applicator device
US20160199579A1 (en) * 2011-01-10 2016-07-14 Zogenix, Inc. Needle free injectors
WO2013009897A1 (en) 2011-07-11 2013-01-17 Medpro Safety Products, Inc. Fluid delivery device and methods
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9408972B2 (en) 2011-08-02 2016-08-09 Pharmajet, Inc. Needle-free injection device
IN2014CN03873A (en) 2011-12-13 2015-10-16 Pharmajet Inc
CA2860711A1 (en) * 2012-01-06 2013-07-11 Svw Technologies Pty Ltd Method and apparatus for castration of animals
PT2822618T (en) 2012-03-06 2024-03-04 Antares Pharma Inc Prefilled syringe with breakaway force feature
EP2833944A4 (en) 2012-04-06 2016-05-25 Antares Pharma Inc Needle assisted jet injection administration of testosterone compositions
WO2013163088A1 (en) 2012-04-23 2013-10-31 Zogenix, Inc. Piston closures for drug delivery capsules
WO2013169800A1 (en) 2012-05-07 2013-11-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US10272204B2 (en) * 2012-08-20 2019-04-30 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method for electrically detecting contact between piston rod and cartridge bung
DK2885032T3 (en) * 2012-08-20 2018-05-22 Sanofi Aventis Deutschland PHARMACEUTICAL APPLICATION DEVICE AND METHOD FOR DETECTING CONTACT BETWEEN PISTON PISTON AND PATTERN PROTECTOR AT DISTANCE MEASUREMENT
EP2732770B1 (en) * 2012-11-16 2016-08-24 Erbe Elektromedizin GmbH Needle-free injection device
KR101313633B1 (en) 2013-01-18 2013-10-02 한국기계연구원 Needle free injector
PT2953667T (en) 2013-02-11 2020-01-28 Antares Pharma Inc Needle assisted jet injection device having reduced trigger force
CN115804749A (en) 2013-03-11 2023-03-17 度瑞公司 Injectable controlled release compositions comprising high viscosity liquid carriers
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
GB2517896B (en) * 2013-06-11 2015-07-08 Cilag Gmbh Int Injection device
GB2515039B (en) 2013-06-11 2015-05-27 Cilag Gmbh Int Injection Device
GB2515038A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Injection device
GB2515032A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Guide for an injection device
EP2829290A1 (en) * 2013-07-25 2015-01-28 Sanofi-Aventis Deutschland GmbH Drive unit for a drug delivery device
EP3041537A1 (en) * 2013-09-03 2016-07-13 Sanofi Mechanism for a drug delivery device and drug delivery device comprising the mechanism
CA2833685A1 (en) * 2013-11-18 2015-05-18 Duoject Medical Systems Inc. Auto-injector
EP2902061A1 (en) * 2014-01-30 2015-08-05 Sanofi-Aventis Deutschland GmbH Medicament delivery device
JP6167048B2 (en) * 2014-02-14 2017-07-19 株式会社ダイセル Needleless syringe
JP6468581B2 (en) * 2014-02-19 2019-02-13 株式会社ダイセル Needleless syringe
US10159793B2 (en) * 2014-06-30 2018-12-25 Portal Instruments, Inc. Nozzle for use in an ultra-high velocity injection device
KR101484754B1 (en) * 2014-08-08 2015-01-20 주식회사 유니온 메디칼 Airjet handpiece
ES2893152T3 (en) 2015-01-21 2022-02-08 Antares Pharma Inc Variable dosage injection device
JP6617158B2 (en) * 2015-05-04 2019-12-11 エルテーエス ローマン テラピー−ジステーメ アーゲー Disposable syringe with increased trigger reliability
JP6652976B2 (en) * 2015-05-04 2020-02-26 エルテーエス ローマン テラピー−ジステーメ アーゲー Disposable syringe with open assembly unit for easy assembly
WO2016177390A1 (en) * 2015-05-04 2016-11-10 Lts Lohmann Therapie-Systeme Ag Disposable injector having a sound-proofing layer
FR3038231B1 (en) * 2015-06-30 2017-07-28 Crossject NEEDLE-FREE INJECTION DEVICE EQUIPPED WITH IMPROVED SEALING MEMBRANE
US10369572B2 (en) 2015-07-31 2019-08-06 Point Of Care Diagnostics, Llc Reagent dispensing apparatus
WO2017029703A1 (en) 2015-08-18 2017-02-23 株式会社ダイセル Needle-free injector
US10328205B2 (en) * 2016-07-07 2019-06-25 Shl Medical Ag Drug delivery device with pneumatic power pack
FR3057169B1 (en) * 2016-10-11 2022-04-01 Crossject INJECTION NOZZLE FOR NEEDLELESS INJECTION DEVICE
DE102017102765A1 (en) 2017-02-13 2018-08-16 Rudolf Götz Kit-of-Parts
US11207509B2 (en) 2017-06-15 2021-12-28 Wiesman Holdings, LLC Method and device for delivery of a solution into a body orifice
WO2019034204A1 (en) * 2017-08-15 2019-02-21 Prejex Holding Gmbh Sample injection device for subcutaneous liquid injection
USD918388S1 (en) 2018-06-15 2021-05-04 Wiesman Holdings, LLC Solution diffusing head
RU2708948C1 (en) * 2019-04-02 2019-12-12 Акционерное общество "Конструкторское бюро химавтоматики" (АО КБХА) Hydraulic needle-less injector
JP2020036916A (en) * 2019-11-01 2020-03-12 エルテーエス ローマン テラピー−ジステーメ アーゲー Disposable injector having sound-proofing layer
JP2020036915A (en) * 2019-11-01 2020-03-12 エルテーエス ローマン テラピー−ジステーメ アーゲー Single-use injector having release assembling unit for simplifying assembling
GB2591076B (en) * 2019-12-18 2024-01-03 Avaxzipen Ltd Improvements in needle-free delivery
GB2590635B (en) * 2019-12-20 2022-08-17 Owen Mumford Ltd Gap creation device
KR102154125B1 (en) * 2020-03-27 2020-09-09 (주)딥셀라이트 Ampoule syringe

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2322244A (en) * 1940-03-18 1943-06-22 Marshall L Lockhart Hypodermic injector
US2322245A (en) * 1943-05-20 1943-06-22 Marshall L Lockhart Ypodermic injector and method of use thereof
US2380534A (en) * 1941-04-26 1945-07-31 Marshall L Lockhart Hypodermic injector
US2398544A (en) * 1945-01-06 1946-04-16 Marshall L Lockhart Hypodermic injector
US2550053A (en) * 1948-04-13 1951-04-24 Becton Dickinson Co Injection device
US2737946A (en) * 1949-09-01 1956-03-13 Jr George N Hein Hypodermic injection apparatus
BE502566A (en) * 1951-03-19
US2764977A (en) * 1951-05-24 1956-10-02 Becton Dickinson Co Hypodermic injection mechanism
US2724383A (en) * 1951-06-28 1955-11-22 Compule Corp Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations
US2689566A (en) * 1951-09-28 1954-09-21 Compule Corp Plural-compartment admixing vial for segregated storage of ingredients of solutions and liquid mixtures
US2693185A (en) * 1951-12-01 1954-11-02 Compule Corp Hypodermic syringe and aspirating ampoule thereof
US2693184A (en) * 1951-12-01 1954-11-02 Compule Corp Hypodermic syringe and aspirating ampoule thereof
US2695614A (en) * 1952-12-10 1954-11-30 Compule Corp Plural-compartment admixing vial
US2762369A (en) * 1954-09-07 1956-09-11 Scherer Corp R P Hypodermic injector with adjustable impact plunger
US2772369A (en) * 1955-10-28 1956-11-27 Gen Electric Parallel operation of tap changing transformers
GB993309A (en) * 1961-04-11 1965-05-26 Express Injector Company Ltd Improved hypodermic injector
GB971162A (en) * 1961-11-21 1964-09-30 British Oxygen Co Ltd Injection inoculation instruments
US3115133A (en) * 1962-05-15 1963-12-24 Morando Emilio Donald Needleless prefilled disposable hypodermic injector
US3650084A (en) * 1968-01-15 1972-03-21 Scherer Corp R P Method for filling and sealing plastic ampoules
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
BE795162A (en) * 1972-02-10 1973-08-08 Philips Nv INJEKTIE-INRICHTING
US3802430A (en) * 1972-06-30 1974-04-09 L Arnold Disposable pyrotechnically powered injector
DE2254153A1 (en) * 1972-11-04 1974-05-09 Werner Dipl Ing Kullmann Automatic universally applicable hypodermic syringe - for veterinary treat-ment of animals or for drugging them at long range
US3782380A (en) * 1973-01-04 1974-01-01 Gaast H V D Medicament injecting device
US3859996A (en) * 1973-07-18 1975-01-14 Mizzy Inc Multi-dose injector
US3831601A (en) * 1973-10-29 1974-08-27 Rohe Scientific Corp Adjustable syringe plunger
JPS51130094A (en) * 1975-05-08 1976-11-12 Asahi Chemical Ind Twoostage pressure injector
US4089334A (en) * 1976-10-07 1978-05-16 Schwebel Paul R Pyrotechnically powered needleless injector
US4124024A (en) * 1977-03-03 1978-11-07 Schwebel Paul R Disposable hypodermic injection ampule
US4227528A (en) * 1978-12-26 1980-10-14 Wardlaw Stephen C Automatic disposable hypodermic syringe
GB2084704B (en) * 1980-10-01 1983-06-29 Theobald David Reginald Air rifle
SE425261B (en) * 1981-02-02 1982-09-13 Sandvik Ab CONFERENCE ON DRILL CHRONICLE AND DRILLER INTENDED TO USE SUCH A CONNECTION
US4403609A (en) * 1981-02-24 1983-09-13 Cohen Edgar C Vacuum-compression injector
US4421508A (en) * 1981-02-24 1983-12-20 Cohen Edgar C Vacuum-compression injector
US4507113A (en) * 1982-11-22 1985-03-26 Derata Corporation Hypodermic jet injector
US4518385A (en) * 1983-06-13 1985-05-21 Preci-Tech Ltd. Disposable syringe for needleless injector
US4561856A (en) * 1983-08-18 1985-12-31 Cochran Ulrich D Infusion pump
US4615468A (en) * 1985-02-22 1986-10-07 The United States Of America As Represented By The United States Department Of Energy Gas ampoule-syringe
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
GB2173287B (en) * 1985-04-01 1988-08-10 Utec Bv Air weapon air compression system
US4744786A (en) * 1986-06-17 1988-05-17 Cordis Corporation Infusion pump
US4722728A (en) * 1987-01-23 1988-02-02 Patents Unlimited, Ltd. Needleless hypodermic injector
FR2629348A2 (en) * 1987-09-15 1989-10-06 Bearn Mecanique Aviat Sa Injection head, in particular for mesotherapy and vaccination apparatuses
CH674151A5 (en) * 1987-09-15 1990-05-15 Guenter Wolfgang Holzner Injection device for serules and syringes - using injection pressure established before puncture
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
JPH0284962A (en) * 1988-06-14 1990-03-26 Vci Corp Negative pressure press contact needle free syringe
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
DE8813938U1 (en) * 1988-11-08 1989-12-07 Nothdurft, Klaus, 7000 Stuttgart, De
FR2648352A1 (en) * 1989-06-16 1990-12-21 Merieux Inst IMPROVEMENT IN DOSAGE-FREE NEEDLE INJECTION DEVICES CONTAINED IN CARTRIDGES AND CARTRIDGES FOR USE IN SUCH AN APPARATUS
US5016784A (en) * 1990-02-15 1991-05-21 Dexus Research Inc. Applicator for highly reactive materials
US5062830A (en) * 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
GB9012829D0 (en) * 1990-06-08 1990-08-01 Bernard D J C Reduced diameter dummy piston
WO1992008508A1 (en) * 1990-11-09 1992-05-29 Sy-Quest International Limited Needleless hypodermic jet injector device
US5360410A (en) * 1991-01-16 1994-11-01 Senetek Plc Safety syringe for mixing two-component medicaments
GB9103291D0 (en) * 1991-02-15 1991-04-03 Waverley Pharma Ltd Transfer adaptor
GB9118204D0 (en) * 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
DE4129271C1 (en) * 1991-09-03 1992-09-17 Fresenius Ag, 6380 Bad Homburg, De
US5279576A (en) * 1992-05-26 1994-01-18 George Loo Medication vial adapter
US5334144A (en) * 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
US5476449A (en) * 1992-12-28 1995-12-19 Richmond; Frank M. Needleless multi-liquid medicament delivery system with membranes
SE9303453D0 (en) * 1993-10-20 1993-10-20 Kabi Pharmacia Ab Injection cartridge
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring

Also Published As

Publication number Publication date
EP0710130B1 (en) 2000-12-06
US20040254526A1 (en) 2004-12-16
US20010039394A1 (en) 2001-11-08
RU2179864C2 (en) 2002-02-27
AU7233194A (en) 1995-02-28
CA2167586C (en) 2005-01-25
JP2002065851A (en) 2002-03-05
ATE254939T1 (en) 2003-12-15
ATE197904T1 (en) 2000-12-15
DE69433366T2 (en) 2004-09-09
BR9407156A (en) 1996-09-17
NO312011B1 (en) 2002-03-04
ES2212040T3 (en) 2004-07-16
EP1020200A3 (en) 2001-12-05
NO960395D0 (en) 1996-01-30
KR100223616B1 (en) 1999-10-15
NO20014862D0 (en) 2001-10-05
HK1010697A1 (en) 1999-06-25
JP2005052669A (en) 2005-03-03
EP0834330A3 (en) 1998-04-15
KR100233672B1 (en) 2000-03-15
EP0834330B1 (en) 2003-11-26
DK0710130T3 (en) 2001-01-15
EP0710130A1 (en) 1996-05-08
DE69426390D1 (en) 2001-01-11
JP4035127B2 (en) 2008-01-16
ES2152323T3 (en) 2001-02-01
JPH11514242A (en) 1999-12-07
NO960395L (en) 1996-03-27
WO1995003844A1 (en) 1995-02-09
EP1020200A2 (en) 2000-07-19
DE69426390T2 (en) 2001-04-12
NO20014862L (en) 1996-03-27
US5891086A (en) 1999-04-06
JP3487856B2 (en) 2004-01-19
EP0834330A2 (en) 1998-04-08
DE69433366D1 (en) 2004-01-08

Similar Documents

Publication Publication Date Title
CA2167586A1 (en) Needle-less injector
CA2154853C (en) Nipple plunger
EP0404818B1 (en) Disposable needleless injection system
US5073165A (en) Hypodermic jet injector and cartridge therefor
US20040015125A1 (en) Compact architecture needleless syringe
AU5309898A (en) Jet injector
WO1994003222A3 (en) Reusable pharmaceutical dispenser with full stroke indicator
CA2207991A1 (en) Filling device for a needleless injector cartridge
YU64502A (en) Miniaturized needleless injector
IL107038A (en) Medicament injectors and methods for injection using same
JPH07299140A (en) Disposable needleless injector
US4758226A (en) Device for distribution, particularly for medical use, of a product in predetermined metered amounts
WO1996024398A1 (en) Needle-less injector
JPH03264076A (en) Jet injector
CA2168670A1 (en) Reloadable injector
ES8607737A1 (en) Needleless hypodermic injector

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20140728