CA2165561A1 - Peralkylated Oligopeptide Mixtures - Google Patents

Peralkylated Oligopeptide Mixtures

Info

Publication number
CA2165561A1
CA2165561A1 CA2165561A CA2165561A CA2165561A1 CA 2165561 A1 CA2165561 A1 CA 2165561A1 CA 2165561 A CA2165561 A CA 2165561A CA 2165561 A CA2165561 A CA 2165561A CA 2165561 A1 CA2165561 A1 CA 2165561A1
Authority
CA
Canada
Prior art keywords
peralkylated
amino acid
sets
acid residues
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2165561A
Other languages
French (fr)
Other versions
CA2165561C (en
Inventor
Richard A. Houghten
John M. Ostresh
Sylvie Blondelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torrey Pines Institute for Molecular Studies
Original Assignee
Richard A. Houghten
John M. Ostresh
Sylvie Blondelle
Houghten Pharmaceuticals, Inc.
Torrey Pines Institute For Molecular Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/079,144 external-priority patent/US5846731A/en
Application filed by Richard A. Houghten, John M. Ostresh, Sylvie Blondelle, Houghten Pharmaceuticals, Inc., Torrey Pines Institute For Molecular Studies filed Critical Richard A. Houghten
Publication of CA2165561A1 publication Critical patent/CA2165561A1/en
Application granted granted Critical
Publication of CA2165561C publication Critical patent/CA2165561C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

Abstract

Linear C1-C7-alkyl peralkylated oligopeptide sets of molecules are disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a set contains the same number of two to about ten substituted C1-C7-alkyl peralkylated amino acid residues, and the member chains of a set are present in equimolar amounts. The chains of a set contain one or more predetermined amino acid residues at one or more predetermined positions of the peralkylated oligopeptide chain. The set contains equimolar amounts of at least six different peralkylated amino acid residues at one or more of the same predetermined positions of the peralkylated oligopeptide chain. Libraries of such sets, processes for their use and solid support-linked peralkylated sets are also contemplated, as are specific permethylated oligopeptides.
CA002165561A 1993-06-17 1994-06-10 Peralkylated oligopeptide mixtures Expired - Fee Related CA2165561C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/079,144 1993-06-17
US08/079,144 US5846731A (en) 1993-06-17 1993-06-17 Peralkylated oligopeptide mixtures
US08/257,782 US5480971A (en) 1993-06-17 1994-06-09 Peralkylated oligopeptide mixtures
US08/257,782 1994-06-09
PCT/US1994/006554 WO1995000539A1 (en) 1993-06-17 1994-06-10 Peralkylated oligopeptide mixtures

Publications (2)

Publication Number Publication Date
CA2165561A1 true CA2165561A1 (en) 1995-01-05
CA2165561C CA2165561C (en) 2000-05-16

Family

ID=26761660

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002165561A Expired - Fee Related CA2165561C (en) 1993-06-17 1994-06-10 Peralkylated oligopeptide mixtures

Country Status (7)

Country Link
US (2) US5480971A (en)
EP (1) EP0722458B1 (en)
AT (1) ATE215559T1 (en)
AU (1) AU694438B2 (en)
CA (1) CA2165561C (en)
DE (1) DE69430312T2 (en)
WO (1) WO1995000539A1 (en)

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Also Published As

Publication number Publication date
ATE215559T1 (en) 2002-04-15
US5480971A (en) 1996-01-02
EP0722458B1 (en) 2002-04-03
EP0722458A1 (en) 1996-07-24
EP0722458A4 (en) 1999-05-19
AU7171994A (en) 1995-01-17
DE69430312T2 (en) 2002-10-02
AU694438B2 (en) 1998-07-23
CA2165561C (en) 2000-05-16
DE69430312D1 (en) 2002-05-08
WO1995000539A1 (en) 1995-01-05
US5763193A (en) 1998-06-09

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