CA2163426A1 - Method and apparatus for desorption and ionization of analytes - Google Patents

Method and apparatus for desorption and ionization of analytes

Info

Publication number
CA2163426A1
CA2163426A1 CA002163426A CA2163426A CA2163426A1 CA 2163426 A1 CA2163426 A1 CA 2163426A1 CA 002163426 A CA002163426 A CA 002163426A CA 2163426 A CA2163426 A CA 2163426A CA 2163426 A1 CA2163426 A1 CA 2163426A1
Authority
CA
Canada
Prior art keywords
desorption
analytes
mass spectrometry
sample probe
ionization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002163426A
Other languages
French (fr)
Other versions
CA2163426C (en
Inventor
T. William Hutchens
Tai-Tung Yip
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
T. William Hutchens
Tai-Tung Yip
Baylor College Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by T. William Hutchens, Tai-Tung Yip, Baylor College Of Medicine filed Critical T. William Hutchens
Priority to CA002512290A priority Critical patent/CA2512290C/en
Publication of CA2163426A1 publication Critical patent/CA2163426A1/en
Application granted granted Critical
Publication of CA2163426C publication Critical patent/CA2163426C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/onization, time-of flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
CA002163426A 1993-05-28 1994-05-27 Method and apparatus for desorption and ionization of analytes Expired - Lifetime CA2163426C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002512290A CA2512290C (en) 1993-05-28 1994-05-27 Method and apparatus for desorption and ionization of analytes

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6889693A 1993-05-28 1993-05-28
US068,896 1993-05-28
PCT/US1994/006064 WO1994028418A1 (en) 1993-05-28 1994-05-27 Method and apparatus for desorption and ionization of analytes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002512290A Division CA2512290C (en) 1993-05-28 1994-05-27 Method and apparatus for desorption and ionization of analytes

Publications (2)

Publication Number Publication Date
CA2163426A1 true CA2163426A1 (en) 1994-12-08
CA2163426C CA2163426C (en) 2005-11-01

Family

ID=22085400

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002512290A Expired - Lifetime CA2512290C (en) 1993-05-28 1994-05-27 Method and apparatus for desorption and ionization of analytes
CA002163426A Expired - Lifetime CA2163426C (en) 1993-05-28 1994-05-27 Method and apparatus for desorption and ionization of analytes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002512290A Expired - Lifetime CA2512290C (en) 1993-05-28 1994-05-27 Method and apparatus for desorption and ionization of analytes

Country Status (12)

Country Link
US (9) US5719060A (en)
EP (2) EP0700521B1 (en)
JP (3) JP3639594B2 (en)
AT (1) ATE242485T1 (en)
AU (1) AU676582B2 (en)
CA (2) CA2512290C (en)
DE (1) DE69432791T2 (en)
DK (1) DK0700521T3 (en)
ES (1) ES2201077T3 (en)
NZ (1) NZ267842A (en)
PT (1) PT700521E (en)
WO (1) WO1994028418A1 (en)

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