CA2159991A1 - Encapsulated sodium percarbonate particles, method of producing them, and washing-agent, cleaning-agent and bleaching-agent compositions containing them - Google Patents

Encapsulated sodium percarbonate particles, method of producing them, and washing-agent, cleaning-agent and bleaching-agent compositions containing them

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Publication number
CA2159991A1
CA2159991A1 CA002159991A CA2159991A CA2159991A1 CA 2159991 A1 CA2159991 A1 CA 2159991A1 CA 002159991 A CA002159991 A CA 002159991A CA 2159991 A CA2159991 A CA 2159991A CA 2159991 A1 CA2159991 A1 CA 2159991A1
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CA
Canada
Prior art keywords
sodium percarbonate
weight
coating
particles
peroxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002159991A
Other languages
French (fr)
Inventor
Birgit Bertsch-Frank
Claas-Jurgen Klasen
Thomas Lieser
Klaus Muller
Martin Bewersdorf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2159991A1 publication Critical patent/CA2159991A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B15/00—Peroxides; Peroxyhydrates; Peroxyacids or salts thereof; Superoxides; Ozonides
    • C01B15/055—Peroxyhydrates; Peroxyacids or salts thereof
    • C01B15/10—Peroxyhydrates; Peroxyacids or salts thereof containing carbon
    • C01B15/106—Stabilisation of the solid compounds, subsequent to the preparation or to the crystallisation, by additives or by coating
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B15/00—Peroxides; Peroxyhydrates; Peroxyacids or salts thereof; Superoxides; Ozonides
    • C01B15/055—Peroxyhydrates; Peroxyacids or salts thereof
    • C01B15/10—Peroxyhydrates; Peroxyacids or salts thereof containing carbon
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0039—Coated compositions or coated components in the compositions, (micro)capsules
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3942—Inorganic per-compounds

Abstract

Sodium percarbonate is often used, in the form of encapsulated particles, in washing and cleaning agents in order to increase their shelf life. Sodium percarbonate particles encapsulated as proposed by the invention have an envelope containing the products of the reaction between a di-alkali-metal tetraborate or alkali-metal pentaborate and aqueous hydrogen peroxide. Preferred envelope components are perborax compounds of the formula Na2B4O7.nH2O2 in which n is 1 or 4. The encapsulated sodium percarbonate particles are produced by coating the percarbonate particles using a solution containing the specified reaction products.
Washing, bleaching and cleaning agents containing sodium percarbonate particles encapsulated as proposed by the invention are characterized by their very long shelf life.

Description

Description - -This invention relates to coated sodium percarbonate particles, of which the coating contains a peroxygen-contAin;ng boron compound which imparts high storage stability to the sodium perc~rhon~te. The present invention also relates to a process for the production of the coated sodium percarbonate particles by application of one or more coating components, more particularly in the form of an aqueous solution con~ining them, to the sodium percarbonate to be coated and to detergent, cleaning and bleaching compositions contAin;ng coated sodium percarbonate particles according to the invention.
Sodium percarbonate (2 Na2CO3 3 H2O2) is used as an active oxygen component in detergents, bleaches and cleaning preparations. In view of the inadequate storage stability of sodium percarbonate in a humid environment and in the presence of various components of detergents and cleAn;ng preparations, sodium percarbonate has to be stabilized against the loss of active oxygen (O~). A key principle for stabilization is to ~LLound the sodium percarbonate particles with a coating of stabilizing components. Thus, it is known that sodium percarbonate can be coated with paraffin or polyethylene glycol.
Unfortunately, adequate long-term stability is not achieved in this way, in addition to which solubility in water is undesirably reduced. Even the application of a coating of alkali metal silicate to the sodium percar-bonate particles, as proposed in DE-OS 26 52 776, does not lead to adequate stabilization and, in addition, .

introduces an unwanted content of insoluble constituents.
In the processes known from DE-OS 24 17 572 and DE-OS 26 22 610, sodium sulfate and sodium carbonate or sodium sulfate, sodium carbonate and sodium silicate are used as coating components. In these processes, a solution of the coating components is sprayed onto sodium percar-bonate particles in a fluidized bed dryer. Adequate stabilization requires a large quantity of coating material which in turn leads to a correspon~ingly large reduction in the active oxygen content.
Although it is known from DE-PS 28 00 916 that a coating material cont~ining at least one boron compound from the group consisting of metaboric acid, orthoboric acid and tetraboric acid can be used for stabilizing sodium percarbonate, the stabilizing effect obtained in this way is described as inadequate in DE-OS 33 21 082, as demonstrated in the Comparison Examples. Instead, sodium percarbonate with a shell cont~ining sodium borate is described as advantageous. However, as the inventors of the present application discovered when copying the Examples of DE-OS 33 21 082, the borate and, optionally, other coating components - to achieve adequate stability - had to be present in the coating in such a quantity that the available active oxygen content of the sodium percarbonate thus stabilized was always below 14~ by weight. A further development of stabilization using borates is described in EP-A 0 487 256, although the coating process disclosed therein involves at least two stages and is therefore technically complicated.
Finally, DE-AS 24 58 326 describes a process for stabilizing sodium percarbonate, the storage stability of the pure product being increased, even in admixture with cleaning preparations. In this process, the sodium percarbonate is coated with a hydrophobic liquid organic compound to which sodium perborate powder is added. The - 21S999l disadvantage of this process lies in the need to use a hydrophobic liquid organic compound which has to be diluted with a lower alcohol in the interests of better handling. In addition, the quantities in which the coating chemicals are used, namely 5 to 20% by weight of sodium perborate and 5 to 10% by weight of hydrophobic organic com~o~.d, based on sodium percarbonate, are very high.
Coated sodium percarbonate particles consisting of a æodium percarbonate core and a coating of sodium perborate with the general formula NaB02 H202 n H20, where n is < 3, are known from DE-PS 26-51 442. Accord-ing to DE-PS 27 12 139, the coating may additionally contain sodium silicate and other water-binding substan-ces. To produce the coated sodium percarbonate particlesmentioned, sodium percarbonate is first wetted with water or an aqueous sodium silicate solution in such a small quantity that the sodium perborate is not converted into the tetrahydrate and is subsequently covered with an-hydrous sodium perborate. A further development of theprocess outlined above is described in DE-PS 28 iO 379 and comprises spraying sodium percarbonate with an aqueous solution of sodium perborate cont~;n;ng 50 to 500 g of sodium perborate tetrahydrate per liter of solution at 40 to 60C and with a sodium silicate solution and then completely or partly removing the water introduced.
As disclosed in hitherto unpublished German patent application P 43 06 399.3, the process described above can be considerably simplified by washing sodium percar-bonate produced by the wet method with a solution con-taining sodium perborate (NaB02 H202) in a solid/liquid separator after at least partial separation of the mother liquor. Despite the small quantity of coating required, high active oxygen stability is achieved in storage of the sodium percarbonate in admixture with a typical zeolite-containing detergent tower powder.
A coating containing perborate monohydrate or tetrahydrate has the advantage over a coating of sodium percarbonate with borates or boric acid that the active oxygen content of the sodium percarbonate particles is hardly affected.
The problem addressed by the present invention was further to improve the stabilization of sodium percar-bonate using new peroxygen-cont~;ning boron compounds and to provide new coated sodium percarbonate particles which, for the same boron content, would guarantee higher active oxygen stability in storage in admixture with detergent constituents than known sodium percarbonate particles having a perborate-cont~ining coating.
Accordingly, the present invention relates to coated sodium percarbonate particles consisting of a core of, essentially, sodium percarbonate and a coating containing at least one peroxygen-containing boron compound, charac-terized in that one or more reaction products from the reaction of a dialkali metal tetraborate or alkali metal pentaborate with aqueous hydrogen peroxide are present as the peroxygen-containing boron compound.
The core of the coated particles consists essential-ly of sodium percarbonate. By "essentially" is meant that the sodium percarbonate may contain secondary constituents from its production, such as for example soda and small quantities of sodium chloride and also crystallization retarders, for example a metaphosphate or a polycarboxylic acid and typical stabilizers, such as for example magnesium salts and sodium silicate. The term "essentially" also includes sodium percarbonate which already contains a coating of stabilizing compo-nents, for example selected from the group of phospho-nates, phosphates, soda, waterglass, magnesium salts, aminocarboxylates and aminophosphonates and also polymer-ic hydroxycarboxylates. In principle, any coatingcomponents already present may even be known boron compounds, although this does appear to be inappropriate where coated sodium percarbonate particles of low boron content are to be produced.
The sodium percarbonate to be used in the process according to the invention may-have been produced by a st~n~Ard process. St~n~rd production processes include in particular so-called wet processes in which soda and hydrogen peroxide are reacted in aqueous phase and sodium percarbonate is crystallized; and so-called spray proces-ses in which an aqueous solution containing soda and hydrogen peroxide is sprayed onto sodium percarbonate particles in a fluidized bed dryer; and so-called dry processes in which a concentrated hydrogen peroxide solution is reacted with anhydrous soda. If desired, a st~n~Ard production process may be followed by a standard coating process.
In their stabilizing shell, the coated sodium percarbonate particles according to the invention contain peroxygen-contA;ning reaction products which emanate from the reaction of a dialkali metal tetraborate or alkali metal pentaborate with aqueous hydrogen peroxide and which are completely or partly freed from water under st~n~rd drying conditions of correspondingly coated sodium percarbonate particles. The drying and water removal ph~ec may be accompanied by melting processes.
It is not yet known whether the resulting peroxygen-containing boron compounds are pure adducts of hydrogen peroxide with the tetraborate or pentaborate or compounds containing the structural element -B-0-0-H or -B-0-0-B-.
It may even be possible that the peroxygen-containing tetra- and pentaborate(s) undergo partial disproportiona-tion during the production-related drying process, so that a boric acid and a perborate containing the struc-tural element:

~~ ~~n~~{
~o~`o of `o~

known from so-called sodium perborate monohydrate may be present alongside one another in the coating.
According to Ullmann's Encyclopedia of Industrial Chemistry, 5th Edition (1985), Vol. A4, 2;70, the tetra-borates and pentaborates used for the formation of the peroxygen-contA;n;ng boron compounds mentioned above have the following anion structure:

_ HO--B O B--OH
o l~l ~B--O O--EI~

OH
The tetraborate and pentaborate contain lithium, sodium or potassium as cation, sodium being preferred.
Preferred coated sodium percarbonate particles contain a so-called perborax correspon~in~ to the general formula Na2B407 n Hz02 m H20, where n is an integer of 1 to 4 and m is an integer of 0 to 9, as the peroxygen-contA;n;ng boron compound in the coating. 2 To 4 mols of ~ydLoyen peroxide and 0 to 2 mols of water are preferably bound per mol of tetraborate. In a particularly prefer-red embodiment, the coating essentially contains Na2B~07 4 H20z.
In addition to the peroxygen-cont~; n ing perboron compounds according to the invention, such as in par-ticular perborax corresponding to the general formula NazB~O7 4 H2O2, the coating may additionally contain other known stabilizing coating components in uniform distribution, for example those already mentioned in the preamble. If desired, the coating according to the - 21S999l invention may be surrounded by other layers containing other stabilizers than the peroxygen-containing perboron compounds used in accordance with the invention and optionally by other layers containing individual consti-tuents of typical detergent and cleaning compositions,for example zeolites. These additional layers may have been applied to the sodium percarbonate particles coated in accordance with the invention by standard methods, i.e. in particular by spray, mixing and granulation processes.
The sodium percarbonate particles coated in accord-ance with the invention may contain widely varying quantities of coating material. Although quantities of 1 to more than 30% by weight, based on sodium percar-bonate, are possible, quantities of 1 to 10~ by weightand preferably 2 to 6~ by weight of coating material have proved to be advantageous in practice. On the one hand, these limited quantities provide for adequate stabiliza-tion of the sodium percarbonate against losses of active oxygen during storage in humid conditions in the presence of typical detergent, cleaning and bleaching composi-tions; on the other hand, the boron content of the coated sodium percarbonate remains at a low level.
As already mentioned, the single-layer or multiple layer coating of the sodium percarbonate particles according to the invention may contain other coating components in addition to the reaction products of hydrogen peroxide with a tetraborate or pentaborate.
Advantageously, the coating as a whole contains more than 50% by weight and, in particular, more than 70% by weight of the above-mentioned reaction products of hydrogen peroxide with a tetraborate or pentaborate and less than 50% by weight and in particular less than 30% by weight of other stabilizing compounds. Sodium percarbonate particles coated in accordance with the invention with a single coating layer essentially containing only the peroxygen-containing boron compounds to be used in accordance with the invention show an extremely high level of stability in storage in the presence of deter-gent tower powders which is not achieved where st~n~rdperborate is used on its own, despite the same boron content. This is extremely surprising because perborax with the formula Na2B407 4 H202 is ~ess stable as such than sodium perborate monohydrate for example.
The sodium percarbonate particles coated in accord-ance with the invention may be obtained by application of at least one peroxygen-contA;ning boron compound and, if desired, other coating components, preferably using an aqueous solution cont~; n i~g the coating components, to particles consisting essentially of sodium percarbonate and, if nec~ccAry~ drying the resulting moist particles.
The process is characterized in that one or more reaction products from the reaction of a dialkali metal tetra-borate or alkali metal pentaborate with aqueous hydrogen peroxide is used as the peroxygen-containing boron compound.
The coating components are preferably applied to the sodium percarbonate particles in the form of one or more aqueous solutions. The reaction mixture from the reac-tion of a tetraborate or pentaborate with hydrogenperoxide is best directly used.
If desired, the boron compounds cont~in;ng active oxygen may be recovered from the reaction mixture in the form of a further concentrated solution or even as a solid by partial or complete evaporation of the water present and may be used as such for the process according to the invention. The reaction mixture is best directly prepared in such a way that the desired concentration of peroxygen-containing boron compounds is maintained. By virtue of the high solubility of the reaction products of tetraborates and pentaborates with hydrogen peroxide, highly concentrated solutions of the peroxygen-containing boron compounds are obtained. Solutions such as these have the advantage that, when they are applied to sodium percarbonate particles by a spray nozzle, no blockages of the spray nozzle and hence no malfunctions occur. At the same time, only a small quantity of water has to be removed in the drying process. In the preparation of the reaction mixture, the reactants are used in such a guan-tity that an atomic ratio of boron to active oxygen of1:0.2 to 1:1.5 is obtained. However, an atomic ratio of boron to active oxygen of 1:0.5 to 1:1.25 is preferred, an atomic ratio of 1 to substantially 1 being particular-ly preferred. In a particularly preferred embodiment, the solution to be applied to the sodium percarbonate particles contains a perborax with the general formula Na2B407 n H202, where n is an integer of 1 to 4, prefer-ably 2 to 4 and, more preferably, approximately 4. Where a solution cont~;n;~g Na2B407 4 H202 is used, it is of advantage if the solution additionally contains a small excess of hydrogen peroxide corresponding to an atomic ratio of boron to active oxygen of approximately 1:1.05 to 1.15. Solutions such as these may readily be obtained by introducing borax with stirring into an aqueous hydro-gen peroxide solution. Solutions cont~;n;ng, for exam-ple, 20 to 50% by weight and, more particularly, 25 to 40% by weight of perborax with the formula Na2B407 n H202, where n is an integer of 2 to 4, can be prepared in this way for the process according to the invention.
The peroxygen-containing boron compound to be used in accordance with the invention may be continuously or discontinuously applied to particles consisting essen-tially of sodium percarbonate in one or more stages by standard methods. The particles to be coated may either be dry or may contain residual moisture from their -production process. Accordingly, it is even possible to use, for example, centrifuge-moist or partly dried sodium percarbonate. Coated sodium percarbonate particles according to the invention may be obtained by mixing surface-moist sodium percarbonate with powder-form perborax and, if nec~sCAry~ subsequent drying. However, it is of greater advantage to-apply a solution of the coating components to sodium percarbonate particles.
Suitable proc~Ccec are, for example: spraying a solution onto the particles with simultaneous mixing; suitable mixers are, for example, spray mixers, such as rotating tubes, tumble mixers, pan granulators. In an alternative to the embodiment mentioned above, sodium percarbonate produced in a wet process is treated with an aqueous solution containing a peroxygen-cont~ining boron compound according to the invention in a washing installation, for example a solid/liquid separator, and the product thus treated is dried after the removal of excess solution.
This embodiment corresponds to the embodiment according to hitherto unpublished German patent application P 43 06 399.3 except that a solution contA;n;ng sodium perborate (NaB02 H202) is used in the process according to the earlier application. In one particularly advantageous embodiment of the process according to the invention, the aqueous solution is sprayed onto the particles to be coated in a fluidized bed in which the particles are kept in a fluidized state. The particles moistened with the solution sprayed on are simultaneously or subsequently dried. Where a fluidized bed arrangement is used, spraying and drying may be carried out at the same time by using air heated to the drying temperature for fluid-ization .
The solution cont~;n;ng the peroxygen-containing boron compounds to be used in accordance with the inven-tion and optionally other coating components may be at room temperature or at a temperature of up to about 60Cduring the spraying process. Where particularly highly concentrated solutions are used, it is best to heat them, preferably to a temperature of 30 to 50C. Where the solution to be used is prepared from a tetraborate or pentaborate and hydrogen peroxide, the temperature of the solution immediately before it is used will be approxi-mately in the range mentioned under the effect of the heat of solution and the heat of reaction. Instead of preparing the solution from the reactants, it may also be produced by dissolving perborax with the empirical formula Na2B407 4 H202, as described for example in DE-PS 548 432, in water; up to l kg perborax can be dis-solved in 1 liter of water at room temperature.
The moist coated sodium percarbonate obtained by spraying is dried under conditions typically applied in the drying of sodium percarbonate. Accordingly, the drying temperature is in the range from 30 to 90C, preferably in the range from 50 to 80C and more prefer-ably in the range from 50 to 70C. The drying tempera-ture is understood to be the temperature of the particles to be dried. Accordingly, in the particularly preferred embodiment where the process is carried out in a fluid-ized dryer, the fluidized bed temperature is in the above-mentioned temperature range. The temperature at which the drying gas enters the fluidized dryer will therefore be above the fluidized bed temperature.
The sodium percarbonate particles coated in accord-ance with the invention may be used as bleaching com-ponent in detergents, cleaning and bleaching composi-tions. Detergent, cleaning and bleaching compositions containing sodium percarbonate particles coated in accordance with the invention are distinguished by the fact that the sodium percarbonate present therein has an unexpectedly high storage stability, so that there is only a very gradual loss of active oxygen during the storage of such compositions under typical conditions.
The storage stability of sodium percarbonate coated in accordance with the invention in the compositions men-tioned exceeds the level obtained with known coatedsodium percarbonate particles for comparable quantities of coating material and a high starting 0, content.
The detergent, cle~ning and bleaching compositions cont~in;ng sodium percarbonate coated in accor~nce with the invention consist of 1 to 99% by weight of the coated sodium percarbonate and, for the rest (h~l~nce to 100% by weight), of other typical components of such composi-tions. Whereas the content of sodium percarbonate in detergents generally does not exceed 20% by weight, it lS may be distinctly higher in bleaching and cleaning compositions.
The detergent, cleaning and bleaching compositions cont~in;ng sodium percarbonate coated in accordance with the invention contain other components typical of such compositions in the usual concentrations in addition to the active oxygen compound mentioned above. The other components in question include in particular 1. surfactants from the group of cationic, anionic, nonionic, amphoteric or ampholytic surfactants;
2. inorganic and/or organic builders of which the main function is to sequester or complex the metal ions responsible for the hardness of water, for example zeolites, polyphosphates, aminopolyacetic acids and aminopolyphosphonic acids and also polyoxycarboxylic acids;
3. alkaline and inorganic electrolytes, such as for example alkanolamines and silicates, carbonates and sulfates;
4. bleach activators from the group of N-acyl compounds and O-acyl compounds, for example tetraacetyl ethylenediamine (TAED);
5. other constituents of the compositions may be stabilizers for peroxides, such as in particular magnesium salts, redeposition inhibitors, optical brighteners, foam inhibitors, enzymes, disinfec-tants, corrosion inhibitors, fragrances, dyes and pH
regulators. Particulars of individual compounds b~longing to classes 1 to 5 can be found, for example, in DE-OS 33 21 082, pages 14-30.
The sodium percarbonate particles coated in accord-ance with the invention show surprisingly high active oxygen stability both per se and in admixture with detergent, cleaning and bleaching compositions. This high degree of stability is surprisingly achieved with a quantity of coating material of a few percent, based on sodium percarbonate. Although it was known that boric acids, borates and sodium perborate were extremely effective as coating components, the effectiveness of the peroxygen-containing boron compounds preferably used in accordance with the invention eyce~c that of known boron compounds. The process according to the invention may be carried out very simply: by virtue of the very high solubility of perborax and other peroxygen-containing boron compounds to be used in accordance with the inven-tion, an effective coating layer can be obtained in a single process step. In addition, there are no malfunc-tions attributable to blockage of the nozzle. The consumption of energy for drying is also kept very low.
The invention is illustrated by the following Examples.

Example 1 Sodium percarbonate produced by reaction of soda with hydrogen peroxide in aqueous phase and having an active oxygen content (a) of 14.2% by weight was coated in a mixer with a solution cont~;n;ng perborax corre-spon~ing to the general formula Na2B407 4 H202:
The coating solution is prepared by dissolving 100.2 g of borax (Na2B407 lQ H20) in 115.4 g of a 35% by weight aqueous hydrogen peroxide-solution with stirring and moderate spontaneous heating. The solution contains 41%
by weight of Na2B407 4 H20 and 2.2% by weight of H202.
The atomic ratio of boron to active oxygen in the solution is 1:1.13.
1500 g of sodium percarbonate are sprayed with 183 g of the above-mentioned solution in a laboratory plough-share mixer and the moist product is dried at 60C in a fluidized bed dryer.
0~ content of the coated sodium percarbonate: 14.4%
by weight; boron content of the coated sodium percar-bonate: 0.61% by weight, calculated from the quantity of Na2B407 4 H202 applied and based on coated sodium percar-bonate. The a stability of the coated sodium percar-bonate added to a commercial zeolite-cont~;n;ng detergent tower powder (Persil Supra TP) - 15 parts by weight of coated sodium percarbonate and 85 parts by weight of tower powder - during storage of the mixture under humid conditions in detergent packs is shown in the Table.
Example 2 Sodium percarbonate (according to Example 1) was sprayed with a perborax (Na2B407 4 H202)-containing solution and simultaneously dried in a fluidized bed dryer.

The solution was prepared by dissolving borax in 19.5% by weight H202 solution. Content of Na2B407 4 H202 31.2~ by weight; atomic ratio of boron to active oxygen 1:1. The solution was sprayed onto the percarbonate through a two-component nozzle at a fluidized bed temper-ature of 50-C (entry temperature of the drying air llO-C). The quantity sprayed corresponded to 5 parts by weight of perborax per 100 parts by weight of sodium percarbonate; O.content of the coated sodium percarbonate 14.2% by weight. The a stability of the coated sodium percarbonate added to a detergent powder is shown in the Table (tower powder and mixing ratio as in Example 1).

Example 3 Example 2 was repeated with the difference that the spray solution contained perborax with the formula Na2B407 2 H202; content 28.7% by weight; atomic ratio of boron to active oxygen 1:1.
Quantity of coating 5% by weight, based on sodium percarbonate. a content of the coated sodium percar-bonate 14.0% by weight. The a stability in a detergent tower powder is again shown in the Table (tower powder and mixing ratio as in Example 1).

Example 4 Centrifuge-moist sodium percarbonate - prepared by reaction of soda with hydrogen peroxide in aqueous phase in the presence of sodium chloride and sodium hexameta-phosphate and crystallization - was aftertreated in the centrifuge by washing with a perborax solution (33% by weight, based on Na2B407 4 H202) after removal of the mother liquor and subsequently dried in a fluidized bed dryer. The quantity of Na2B407 4 H202 applied corre-sponded to 2.5% by weight, based on sodium percarbonate.
The boron content was approximately 0.3~ by weight. The .
-a content of the coated percarbonate was 14.2% by weight.
The storage stability is shown in the Table.

Comparison Example ~
Sodium percarbonate was coated with 5% by weight of orthoboric acid, based on sodium percarbonate, by the process according to DE-PS 28 00 916 (see Example A6 of this document). a content of the coated sodium percar-bonate 13.4% by weight; boron content, based on coated sodium percarbonate, 0.83% by weight. The stability data during storage in the detergent mixture are shown in the Table.

Comparison Example 2 Sodium percarbonate was sprayed with an a~ueous borax solution (concentration 35% by weight) in a mixer (as in Example 1), the quantity of borax sprayed on amounting to 5 parts by weight per 100 parts by weight of sodium percarbonate. The material was then dried at 70C.
a content 13.5% by weight; boron content of the coated percarbonate 0.55% by weight, calculated from the borax applied on the assumption that borax was converted into Na2B407 5 H20 during drying.
Comparison Example 3 Sodium percarbonate was coated with sodium perborate and waterglass in accordance with DE-PS 28 10 379. The quantity of coating corresponded to 6% by weight of sodium perborate monohydrate and 1% by weight of water-glass. a content of the coated sodium percarbonate 14.3%
by weight;= boron content of the coated sodium percar-bonate (calculated from the quantity of NaB02 H202 applied) 0.62% by weight. The stability data in a detergent composition are shown in the Table.

To evaluate stability, coated sodium percarbonate of the Examples and Comparison Examples was stored in admixture with a commercial phosphate-free but zeolite-cont~;n;ng-detergent tower powder (Persil Supra TP) -mixing ratio 15:85 - in sealed detergent packs (0.4 1) ~ placed in a climatic chamber at a constant 30C/80%
relative humidity. The results of the active oxygen measurements of the mixtures carried out in the usual way at the beginn;ng and after storage for 2, 4 and 8 weeks are shown in the Table. For substantially the same boron content, sodium percarbonate particles coated in accord-ance with the invention show a higher stability in storage than the sodium percarbonate particles coated with boric acid, borax or perborate monohydrate.

~n x U --~ .. . .
~ ~o o ~ ~1 ~1 o -.C .
~ In ~ ~- ~ ~o o o ~
o oo a~ o _ _ C ~ ~
~Q i o I`
R

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R ~
~ J
--~ ~ er ~ o ~ ~ U~ ~

R ~1 ~q ~ 0 0 0 J ~
~ O ~ o o o o o o o wX V ~ r o~
R ~ o d~ ~ ~
E~m o ~n v ~J N ~1 N O

~ O
'_ ~ ~ ~ ~ ~ 0 ~1 ~ ~
R a:~ ~ m~
u,~-- zu~ z~ Zu. z~ m~ z~ z~O

~ o ,1 ,I h ~1 ~7 X O O X

Claims (10)

CLAIMS:
1. Coated sodium percarbonate particles consisting of a core of, essentially, sodium percarbonate and a coating containing at least one peroxygen-containing boron compound, characterized in that one or more reaction products from the reaction of a dialkali metal tetra-borate or alkali metal pentaborate with aqueous hydrogen peroxide are present as the peroxygen-containing boron compound.
2. Coated sodium percarbonate particles as claimed in claim 1, characterized in that the peroxygen-containing boron compound in the coating is a perborax with the general formula Na2B4O7 n H2O2 m H2O, where n is an integer of 1 to 4 and preferably 2 to 4 and m is an integer of 0 to 9 and preferably 0 to 2.
3. Coated sodium percarbonate particles as claimed in claim 1 or 2, characterized in that the quantity of coating, based on sodium percarbonate, makes up 1 to 10%
by weight and preferably 2 to 6% by weight.
4. Coated sodium percarbonate particles as claimed in any of claims 1 to 3, characterized in that the coating consists of more than 50% by weight and preferably more than 70% by weight of the reaction products of hydrogen peroxide with a tetraborate or pentaborate and less than 50% by weight and preferably less than 30% by weight of other stabilizing compounds.
5. A process for the production of coated sodium percarbonate particles consisting of a core of, essen-tially, sodium percarbonate and a coating of one or more coating components, including at least one peroxygen-containing boron compound, by application of at least one peroxygen-containing boron compound and, if required, other coating components, preferably using an aqueous solution containing the coating components, to particles consisting essentially of sodium percarbonate and, if necessary, drying of the moist particles, characterized in that one or more reaction products from the reaction of a dialkali metal tetraborate or alkali metal penta-borate with aqueous hydrogen peroxide is used as the peroxygen-containing boron compound.
6. A process as claimed in claim 5, characterized in that the reaction products mentioned are used in the form of an aqueous solution, preferably of the reaction mixture, the solution mentioned containing boron and active oxygen in an atomic ratio of 1:0.2 to 1:1.5, preferably 1:0.5 to 1:1.25 and more preferably 1:sub-stantially 1.
7. A process as claimed in claim 5 or 6, characterized in that the solution to be applied contains a perborax with the general formula Na2B4O7 n H2O2, where n is an integer of 1 to 4 and preferably 2 to 4.
8. A process as claimed in any of claims 5 to 7, characterized in that the solution to be applied contains 20 to 50% by weight and more particularly 25 to 40% by weight of perborax with the general formula Na2B4O7 n H2O2, where n is an integer of 2 to 4, more particularly 4.
9. A process as claimed in any of claims 5 to 8, characterized in that an aqueous solution containing the peroxygen-containing boron compound is sprayed onto particles consisting essentially of sodium percarbonate either in a mixer or in a fluidized bed dryer and the resulting moist particles are simultaneously or subse-quently dried at 30 to 90°C and preferably at 50 to 80°C.
10. Detergent, cleaning and bleaching compositions containing coated sodium percarbonate particles according to any of claims 1 to 3 or obtained by the process claimed in claims 4 to 9.
CA002159991A 1993-04-10 1994-02-28 Encapsulated sodium percarbonate particles, method of producing them, and washing-agent, cleaning-agent and bleaching-agent compositions containing them Abandoned CA2159991A1 (en)

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Families Citing this family (542)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335434B1 (en) 1998-06-16 2002-01-01 Isis Pharmaceuticals, Inc., Nucleosidic and non-nucleosidic folate conjugates
US8153602B1 (en) 1991-11-19 2012-04-10 Isis Pharmaceuticals, Inc. Composition and methods for the pulmonary delivery of nucleic acids
JP3484197B2 (en) 1993-09-03 2004-01-06 アイシス・ファーマシューティカルス・インコーポレーテッド Amine derivatized nucleosides and oligonucleosides
DE4439069A1 (en) * 1994-11-02 1996-05-09 Degussa Percarbonate containing detergent, bleach and detergent composition
DE19629381A1 (en) * 1996-07-20 1998-01-22 Eilenburger Elektrolyse & Umwelttechnik Gmbh Sodium peroxo:di:sulphate and sodium hydroxide production by electrolysis
DE19544293C2 (en) * 1995-11-28 1998-01-29 Degussa Encased sodium percarbonate particles and their use
DE19600018A1 (en) 1996-01-03 1997-07-10 Henkel Kgaa Detergent with certain oxidized oligosaccharides
US20030044941A1 (en) 1996-06-06 2003-03-06 Crooke Stanley T. Human RNase III and compositions and uses thereof
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US6639062B2 (en) 1997-02-14 2003-10-28 Isis Pharmaceuticals, Inc. Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom
JP2002510319A (en) 1997-07-01 2002-04-02 アイシス・ファーマシューティカルス・インコーポレーテッド Compositions and methods for delivery of oligonucleotides through the gastrointestinal tract
FR2768140B1 (en) * 1997-09-05 1999-10-08 Atochem Elf Sa STABLE SUPERSATURATED SODIUM PERBORATE SOLUTION AND ITS APPLICATION IN THE MANUFACTURE OF STABILIZED SODIUM PERCARBONATE PARTICLES
US20040186071A1 (en) 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
WO1999060167A1 (en) 1998-05-21 1999-11-25 Isis Pharmaceuticals, Inc. Compositions and methods for topical delivery of oligonucleotides
EP1469009A2 (en) 1998-05-21 2004-10-20 Isis Parmaceuticals, Inc. Compositions and methods for non-parenteral delivery of oligonucleotides
US6335439B1 (en) 1998-06-11 2002-01-01 Isis Pharmaceuticals, Inc. Method of preparing phosphoramidites
US6225293B1 (en) 1998-09-02 2001-05-01 Isis Pharmaceuticals, Inc. Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations
AU9576798A (en) * 1998-09-23 2000-04-10 Procter & Gamble Company, The Coated perborate bleach and compositions containing the same
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
US6300320B1 (en) 1999-01-05 2001-10-09 Isis Pharmaceuticals, Inc. Modulation of c-jun using inhibitors of protein kinase C
US7098192B2 (en) 1999-04-08 2006-08-29 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of STAT3 expression
US6656730B1 (en) 1999-06-15 2003-12-02 Isis Pharmaceuticals, Inc. Oligonucleotides conjugated to protein-binding drugs
US6147200A (en) * 1999-08-19 2000-11-14 Isis Pharmaceuticals, Inc. 2'-O-acetamido modified monomers and oligomers
US6617442B1 (en) 1999-09-30 2003-09-09 Isis Pharmaceuticals, Inc. Human Rnase H1 and oligonucleotide compositions thereof
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
US20020055479A1 (en) 2000-01-18 2002-05-09 Cowsert Lex M. Antisense modulation of PTP1B expression
EP1127840A1 (en) * 2000-02-21 2001-08-29 SOLVAY & Cie (Société Anonyme) Process for preparing coated alkali metal percarbonate, coated alkaki metal percarbonate obtainable by this process, its use in detergent compositions, and detergent compositions containing it
AU2001253408C1 (en) * 2000-04-13 2008-12-04 Mervyn Merrilees Therapeutic compounds and methods for formulating V3, A Versican Isoform
KR100366556B1 (en) 2000-04-26 2003-01-09 동양화학공업주식회사 Granular coated sodium percarbonate and process for preparing them
US6680172B1 (en) 2000-05-16 2004-01-20 Regents Of The University Of Michigan Treatments and markers for cancers of the central nervous system
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
US8568766B2 (en) 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
JP5305553B2 (en) 2000-10-12 2013-10-02 ユニバーシティー オブ ロチェスター Composition for inhibiting the growth of cancer cells
US7767802B2 (en) 2001-01-09 2010-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
CA2441071C (en) 2001-03-14 2010-06-22 Myriad Genetics, Inc. Tsg101-gag interaction and use thereof
US7803915B2 (en) 2001-06-20 2010-09-28 Genentech, Inc. Antibody compositions for the diagnosis and treatment of tumor
CA2633171C (en) 2001-06-20 2012-11-20 Genentech, Inc. Antibodies against tumor-associated antigenic target (tat) polypeptides
CA2790034A1 (en) 2001-06-21 2003-01-03 Isis Pharmaceuticals, Inc. Antisense modulation of superoxide dismutase 1, soluble expression
US7425545B2 (en) 2001-07-25 2008-09-16 Isis Pharmaceuticals, Inc. Modulation of C-reactive protein expression
US6964950B2 (en) 2001-07-25 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of C-reactive protein expression
US20030096772A1 (en) 2001-07-30 2003-05-22 Crooke Rosanne M. Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US7227014B2 (en) 2001-08-07 2007-06-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein (a) expression
NZ573831A (en) 2001-09-18 2010-07-30 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor, particularly breast tumor - TAT193
US6750019B2 (en) 2001-10-09 2004-06-15 Isis Pharmaceuticals, Inc. Antisense modulation of insulin-like growth factor binding protein 5 expression
NZ566396A (en) 2001-10-09 2009-07-31 Isis Pharmaceuticals Inc Antisense modulation of insulin-like growth factor binding protein 5 expressions
US20030170678A1 (en) * 2001-10-25 2003-09-11 Neurogenetics, Inc. Genetic markers for Alzheimer's disease and methods using the same
US6965025B2 (en) 2001-12-10 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of connective tissue growth factor expression
NZ533933A (en) 2002-01-02 2008-06-30 Genentech Inc Compositions and methods for the diagnosis and treatment of glioma tumor
US7169916B2 (en) * 2002-04-01 2007-01-30 Isis Pharmaceuticals, Inc. Chloral-free DCA in oligonucleotide synthesis
CA2481507A1 (en) 2002-04-16 2003-10-30 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7199107B2 (en) 2002-05-23 2007-04-03 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
US20040092470A1 (en) * 2002-06-18 2004-05-13 Leonard Sherry A. Dry powder oligonucleotide formualtion, preparation and its uses
AU2003257181A1 (en) 2002-08-05 2004-02-23 University Of Rochester Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof
CN1694959B (en) 2002-09-13 2013-09-18 雷普利瑟公司 Non-sequence complementary antiviral oligonucleotides
JP2006500030A (en) * 2002-09-20 2006-01-05 イェール ユニバーシティ Riboswitch, method of using the same, and composition for use with riboswitch
US7229976B2 (en) 2002-09-26 2007-06-12 Isis Pharmaceuticals, Inc. Modulation of forkhead box O1A expression
WO2004044132A2 (en) 2002-11-05 2004-05-27 Isis Pharmaceuticals, Inc. Modified oligonucleotides for use in rna interference
US9150606B2 (en) 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
CA2504720C (en) 2002-11-05 2013-12-24 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US9150605B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
EP1569695B1 (en) 2002-11-13 2013-05-15 Genzyme Corporation Antisense modulation of apolipoprotein b expression
DK2336318T3 (en) 2002-11-13 2013-07-15 Genzyme Corp ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION
JP4555089B2 (en) 2002-11-15 2010-09-29 モーフオテク・インコーポレーテツド Method for producing high production amount of antibody from hybridoma created by in vitro immunization
US8007804B2 (en) 2002-11-15 2011-08-30 Musc Foundation For Research Development Complement receptor 2 targeted complement modulators
AU2003294462C1 (en) 2002-11-21 2011-06-30 University Of Utah Research Foundation Purinergic modulation of smell
US7144999B2 (en) 2002-11-23 2006-12-05 Isis Pharmaceuticals, Inc. Modulation of hypoxia-inducible factor 1 alpha expression
US20040121338A1 (en) * 2002-12-19 2004-06-24 Alsmadi Osama A. Real-time detection of rolling circle amplification products
WO2004058987A2 (en) 2002-12-20 2004-07-15 Qiagen Gmbh Nucleic acid amplification
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
DK1597366T3 (en) 2003-02-11 2013-02-25 Antisense Therapeutics Ltd Modulation of expression of insulin-like growth factor receptor I
US7002006B2 (en) * 2003-02-12 2006-02-21 Isis Pharmaceuticals, Inc. Protection of nucleosides
US7803781B2 (en) 2003-02-28 2010-09-28 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
US20040185559A1 (en) 2003-03-21 2004-09-23 Isis Pharmaceuticals Inc. Modulation of diacylglycerol acyltransferase 1 expression
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US7598227B2 (en) 2003-04-16 2009-10-06 Isis Pharmaceuticals Inc. Modulation of apolipoprotein C-III expression
US7399853B2 (en) 2003-04-28 2008-07-15 Isis Pharmaceuticals Modulation of glucagon receptor expression
AU2004253455B2 (en) 2003-06-03 2011-03-03 Eli Lilly And Company Modulation of survivin expression
EP3604537B1 (en) 2003-06-13 2021-12-08 Alnylam Europe AG Double-stranded ribonucleic acid with increased effectiveness in an organism
US7790691B2 (en) 2003-06-20 2010-09-07 Isis Pharmaceuticals, Inc. Double stranded compositions comprising a 3′-endo modified strand for use in gene modulation
US7683036B2 (en) 2003-07-31 2010-03-23 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
US7825235B2 (en) 2003-08-18 2010-11-02 Isis Pharmaceuticals, Inc. Modulation of diacylglycerol acyltransferase 2 expression
US20050053981A1 (en) 2003-09-09 2005-03-10 Swayze Eric E. Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
AU2004274021B2 (en) 2003-09-18 2009-08-13 Isis Pharmaceuticals, Inc. 4'-thionucleosides and oligomeric compounds
AR045937A1 (en) 2003-09-18 2005-11-16 Lilly Co Eli MODULATION OF THE EXPRESSION OF THE EIF4E EUCARY INITIATION FACTOR
US20050191653A1 (en) 2003-11-03 2005-09-01 Freier Susan M. Modulation of SGLT2 expression
PT2161283E (en) 2003-11-17 2014-08-29 Genentech Inc Compositions comprising antibodies against cd79b conjugated to a growth inhibitory agent or cytotoxic agent and methods for the treatment of tumor of hematopoietic origin
EP1711606A2 (en) 2004-01-20 2006-10-18 Isis Pharmaceuticals, Inc. Modulation of glucocorticoid receptor expression
US8778900B2 (en) * 2004-01-22 2014-07-15 Isis Pharmaceuticals, Inc. Modulation of eIF4E-BP1 expression
US7468431B2 (en) 2004-01-22 2008-12-23 Isis Pharmaceuticals, Inc. Modulation of eIF4E-BP2 expression
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
EP2700720A3 (en) 2004-03-15 2015-01-28 Isis Pharmaceuticals, Inc. Compositions and methods for optimizing cleavage of RNA by RNASE H
US20050244869A1 (en) 2004-04-05 2005-11-03 Brown-Driver Vickie L Modulation of transthyretin expression
WO2005097817A2 (en) 2004-04-05 2005-10-20 Alnylam Pharmaceuticals, Inc. Process and reagents for oligonucleotide synthesis and purification
JP4584987B2 (en) 2004-04-30 2010-11-24 アルニラム ファーマスーティカルズ インコーポレイテッド Oligonucleotides containing C5-modified pyrimidines
AU2005326817B2 (en) 2004-05-21 2012-04-19 Benaroya Research Institute Variable lymphocyte receptors, related polypeptides and nucleic acids, and uses thereof
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US7427675B2 (en) * 2004-08-23 2008-09-23 Isis Pharmaceuticals, Inc. Compounds and methods for the characterization of oligonucleotides
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
DK1809303T3 (en) 2004-09-23 2019-06-11 Arc Medical Devices Inc PHARMACEUTICAL COMPOSITION AND METHODS IN RELATION TO FIBROSE ADHESION OR INFLAMMATORIC DISEASE USING LOW SULPHATE FUCAN
US8765700B2 (en) 2004-10-20 2014-07-01 Antisense Therapeutics Ltd. Topical administrations of antisense compounds to VLA-4 for the treatment of respiratory conditions
US20060105937A1 (en) * 2004-11-15 2006-05-18 Melani Hardt Duran Aqueous cleaning composition
US20100256062A1 (en) 2004-12-06 2010-10-07 Howard Tommy E Allelic Variants of Human Factor VIII
AU2006223498A1 (en) 2005-03-10 2006-09-21 Genentech, Inc. Methods and compositions for modulating vascular integrity
EP1863908B1 (en) 2005-04-01 2010-11-17 Qiagen GmbH Reverse transcription and amplification of rna with simultaneous degradation of dna
GB0508622D0 (en) * 2005-04-28 2005-06-08 Probe Ind Ltd Method for treating effluent
US9505867B2 (en) 2005-05-31 2016-11-29 Ecole Polytechmique Fédérale De Lausanne Triblock copolymers for cytoplasmic delivery of gene-based drugs
WO2006133022A2 (en) 2005-06-03 2006-12-14 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
US8252756B2 (en) 2005-06-14 2012-08-28 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
US7776532B2 (en) 2005-08-11 2010-08-17 Synthetic Genomics, Inc. Method for in vitro recombination
CA2617693A1 (en) 2005-08-17 2007-02-22 Medexis S.A. Composition and method for determination of ck19 expression
EP2338992A3 (en) 2005-08-29 2011-10-12 Regulus Therapeutics, Inc Antisense compounds having enhanced anti-microRNA activity
JP5523705B2 (en) 2005-08-29 2014-06-18 レグルス・セラピューティクス・インコーポレイテッド Method of using to modulate MIR-122A
EP1762627A1 (en) 2005-09-09 2007-03-14 Qiagen GmbH Method for the activation of a nucleic acid for performing a polymerase reaction
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
EP2402435A3 (en) 2005-10-14 2012-03-28 MUSC Foundation For Research Development Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
EP2325315B1 (en) 2005-10-28 2014-05-07 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of huntingtin gene
CA2626584A1 (en) * 2005-11-04 2007-05-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of nav1.8 gene
CA2626690A1 (en) 2005-11-09 2007-05-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of factor v leiden mutant gene
US7807652B2 (en) 2005-11-21 2010-10-05 Isis Pharmaceuticals, Inc. Modulation of eIF4E-BP2 expression
US8313901B2 (en) * 2005-12-21 2012-11-20 Yale University Methods and compositions related to the modulation of riboswitches
EP1976567B1 (en) 2005-12-28 2020-05-13 The Scripps Research Institute Natural antisense and non-coding rna transcripts as drug targets
JP5425474B2 (en) 2006-01-26 2014-02-26 アイシス ファーマシューティカルズ， インコーポレーテッド Composition and use thereof for huntingtin
DK2314594T3 (en) 2006-01-27 2014-10-27 Isis Pharmaceuticals Inc 6-modified bicyclic nucleic acid analogues
CA2640058C (en) 2006-01-27 2018-04-24 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for the use in modulation of micrornas
ES2544861T3 (en) 2006-03-31 2015-09-04 Alnylam Pharmaceuticals Inc. Compositions and methods to inhibit the expression of the Eg5 gene
MX2008014005A (en) 2006-05-03 2009-01-27 Baltic Technology Dev Ltd Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease.
EP2023939B1 (en) 2006-05-05 2012-06-27 Isis Pharmaceuticals, Inc. Compounds and methods for modulating expression of pcsk9
EP2505648A1 (en) 2006-05-05 2012-10-03 Isis Pharmaceuticals, Inc. Compounds and methods for modulating expression of PTP1B
WO2007134181A2 (en) * 2006-05-11 2007-11-22 Isis Pharmaceuticals, Inc. 5'-modified bicyclic nucleic acid analogs
US7666854B2 (en) * 2006-05-11 2010-02-23 Isis Pharmaceuticals, Inc. Bis-modified bicyclic nucleic acid analogs
WO2007137156A2 (en) 2006-05-19 2007-11-29 Alnylam Pharmaceuticals, Inc. Rnai modulation of aha and therapeutic uses thereof
US7888498B2 (en) 2006-05-22 2011-02-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of IKK-B gene
WO2008011473A2 (en) 2006-07-19 2008-01-24 Isis Pharmaceuticals, Inc. Compositions and their uses directed to hbxip
EP2057284A4 (en) * 2006-08-04 2011-06-29 Isis Pharmaceuticals Inc Compositions and methods for the modulation of jnk proteins
US20100137440A1 (en) * 2006-09-11 2010-06-03 Yale University Lysine riboswitches, structure-based compound design with lysine riboswitches, and methods and compositions for use of and with lysine riboswitches
WO2008063758A2 (en) 2006-10-05 2008-05-29 Massachussetts Institute Of Technology Multifunctional encoded particles for high-throughput analysis
ATE540118T1 (en) 2006-10-18 2012-01-15 Isis Pharmaceuticals Inc ANTISENSE COMPOUNDS
WO2008136852A2 (en) 2006-11-01 2008-11-13 University Of Rochester Methods and compositions related to the structure and function of apobec3g
EP2102340A2 (en) * 2006-11-27 2009-09-23 Isis Pharmaceuticals, Inc. Methods for treating hypercholesterolemia
US8093222B2 (en) 2006-11-27 2012-01-10 Isis Pharmaceuticals, Inc. Methods for treating hypercholesterolemia
CA2672297A1 (en) 2006-12-11 2008-06-19 University Of Utah Research Foundation Compositions and methods for treating pathologic angiogenesis and vascular permeability
WO2008094370A2 (en) 2006-12-22 2008-08-07 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
CN103966345A (en) 2007-02-09 2014-08-06 西北大学 Particles for detecting intracellular targets
CA2679586A1 (en) * 2007-02-27 2008-10-23 Northwestern University Molecule attachment to nanoparticles
CN101801185A (en) 2007-03-22 2010-08-11 耶鲁大学 Methods and compositions related to riboswitches that control alternative splicing
EP2905336A1 (en) 2007-03-29 2015-08-12 Alnylam Pharmaceuticals Inc. Compositions and methods for inhibiting expression of a gene from the ebola
CA2690281A1 (en) 2007-05-11 2008-11-20 The Johns Hopkins University Biomarkers for melanoma
EP2426219A1 (en) 2007-05-29 2012-03-07 Yale University Riboswitches and methods and compositions for use of and with riboswitches
EP2164994A4 (en) * 2007-05-29 2010-07-21 Univ Yale Inc Methods and compositions related to riboswitches that control alternative splicing and rna processing
US8278425B2 (en) 2007-05-30 2012-10-02 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
CA2689923A1 (en) 2007-05-30 2008-12-11 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
US7807372B2 (en) * 2007-06-04 2010-10-05 Northwestern University Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay
US8278426B2 (en) 2007-06-08 2012-10-02 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
US8278283B2 (en) * 2007-07-05 2012-10-02 Isis Pharmaceuticals, Inc. 6-disubstituted or unsaturated bicyclic nucleic acid analogs
US8088904B2 (en) 2007-08-15 2012-01-03 Isis Pharmaceuticals, Inc. Tetrahydropyran nucleic acid analogs
US8557767B2 (en) 2007-08-28 2013-10-15 Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
AU2008296478B9 (en) 2007-08-28 2015-03-19 The Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
WO2009039466A1 (en) 2007-09-20 2009-03-26 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
WO2009039442A1 (en) 2007-09-21 2009-03-26 California Institute Of Technology Nfia in glial fate determination, glioma therapy and astrocytoma treatment
US8916531B2 (en) 2007-11-20 2014-12-23 Isis Pharmaceuticals, Inc. Modulation of CD40 expression
EP2617828B1 (en) 2007-12-10 2014-09-24 Alnylam Pharmaceuticals Inc. Compositions and methods for inhibiting expression of factor VII gene
US20110117125A1 (en) 2008-01-02 2011-05-19 Tekmira Pharmaceuticals Corporation Compositions and methods for the delivery of nucleic acids
AU2009221775B2 (en) 2008-03-05 2015-05-07 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of Eg5 and VEGF genes
US8846639B2 (en) * 2008-04-04 2014-09-30 Isis Pharmaceutical, Inc. Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
WO2009124238A1 (en) * 2008-04-04 2009-10-08 Isis Pharmaceuticals, Inc. Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
ES2554168T3 (en) 2008-04-18 2015-12-16 Baxter International Inc. Microsphere-based composition to prevent and / or reverse newly occurring autoimmune diabetes
CN101270232B (en) * 2008-04-22 2011-04-20 浙江时代金科过氧化物有限公司 Method for preparing particle type coating sodium percarbonate
CA2722668A1 (en) * 2008-04-29 2009-11-05 Wyeth Llc Methods for treating inflammation
US8222221B2 (en) 2008-06-04 2012-07-17 The Board Of Regents Of The University Of Texas System Modulation of gene expression through endogenous small RNA targeting of gene promoters
US8901095B2 (en) 2008-07-29 2014-12-02 The Board Of Regents Of The University Of Texas System Selective inhibition of polyglutamine protein expression
ES2657696T3 (en) 2008-08-25 2018-03-06 Excaliard Pharmaceuticals, Inc. Method to reduce healing during wound healing using antisense compounds targeting CTGF
AU2009275387B2 (en) 2008-08-25 2010-07-08 Excaliard Pharmaceuticals, Inc. Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
EP3208337A1 (en) 2008-09-02 2017-08-23 Alnylam Pharmaceuticals, Inc. Compositions for combined inhibition of mutant egfr and il-6 expression
US20100075883A1 (en) * 2008-09-24 2010-03-25 Ecolab Inc. Granular cleaning and disinfecting composition
EP2356129B1 (en) * 2008-09-24 2013-04-03 Isis Pharmaceuticals, Inc. Substituted alpha-l-bicyclic nucleosides
EP3584320A1 (en) 2008-09-25 2019-12-25 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of serum amyloid a gene
CN104119242B (en) 2008-10-09 2017-07-07 泰米拉制药公司 The amino lipids of improvement and the method for delivering nucleic acid
CN106834291B (en) 2008-10-20 2020-09-29 阿尔尼拉姆医药品有限公司 Compositions and methods for inhibiting expression of transthyretin
EP2447274B1 (en) 2008-10-24 2017-10-04 Ionis Pharmaceuticals, Inc. Oligomeric compounds and methods
KR101692880B1 (en) 2008-11-24 2017-01-04 노오쓰웨스턴 유니버시티 Polyvalent rna-nanoparticle compositions
EP2370582B1 (en) 2008-12-04 2017-05-10 CuRNA, Inc. Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
ES2629630T3 (en) 2008-12-04 2017-08-11 Curna, Inc. Treatment of diseases related to erythropoietin (EPO) by inhibiting the natural antisense transcript to EPO
EP2370580B1 (en) 2008-12-04 2019-09-11 CuRNA, Inc. Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirtuin 1
AU2009324534B2 (en) 2008-12-10 2015-07-30 Alnylam Pharmaceuticals, Inc. GNAQ targeted dsRNA compositions and methods for inhibiting expression
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
KR101546673B1 (en) * 2009-01-15 2015-08-25 삼성전자주식회사 Toner for electrophotographic and process for preparing the same
US20120101148A1 (en) 2009-01-29 2012-04-26 Alnylam Pharmaceuticals, Inc. lipid formulation
US8536320B2 (en) 2009-02-06 2013-09-17 Isis Pharmaceuticals, Inc. Tetrahydropyran nucleic acid analogs
WO2010091308A2 (en) 2009-02-06 2010-08-12 Isis Pharmaceuticals, Inc. Oligomeric compounds and methods
ES2560107T3 (en) 2009-02-12 2016-02-17 Curna, Inc. Treatment of diseases related to brain-derived neurotrophic factor (BDNF) by inhibition of natural antisense transcript for BDNF
WO2010093906A2 (en) 2009-02-12 2010-08-19 Curna, Inc. Treatment of glial cell derived neurotrophic factor (gdnf) related diseases by inhibition of natural antisense transcript to gdnf
US20120041051A1 (en) 2009-02-26 2012-02-16 Kevin Fitzgerald Compositions And Methods For Inhibiting Expression Of MIG-12 Gene
WO2010102058A2 (en) 2009-03-04 2010-09-10 Curna, Inc. Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirt 1
WO2010105209A1 (en) 2009-03-12 2010-09-16 Alnylam Pharmaceuticals, Inc. LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES
CA2755409C (en) 2009-03-16 2019-04-30 Joseph Collard Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2
JP5904935B2 (en) 2009-03-17 2016-04-20 クルナ・インコーポレーテッド Treatment of DLK1-related diseases by suppression of natural antisense transcripts against Delta-like 1 homolog (DLK1)
AU2010237001B2 (en) 2009-04-15 2016-07-07 Northwestern University Delivery of oligonucleotide-functionalized nanoparticles
EP3248618A1 (en) 2009-04-22 2017-11-29 Massachusetts Institute Of Technology Innate immune suppression enables repeated delivery of long rna molecules
WO2010124231A2 (en) 2009-04-24 2010-10-28 The Board Of Regents Of The University Of Texas System Modulation of gene expression using oligomers that target gene regions downstream of 3' untranslated regions
CA2760589C (en) 2009-05-01 2019-08-20 Joseph Collard Treatment of hemoglobin (hbf/hbg) related diseases by inhibition of natural antisense transcript to hbf/hbg
CA3045126A1 (en) 2009-05-05 2010-11-11 Arbutus Biopharma Corporation Methods of delivering oligonucleotides to immune cells
KR20180094137A (en) 2009-05-05 2018-08-22 알닐람 파마슈티칼스 인코포레이티드 Lipid compositions
CN102459596B (en) 2009-05-06 2016-09-07 库尔纳公司 By suppression therapy lipid transfer and the metabolic gene relevant disease of the natural antisense transcript for lipid transfer and metabolic gene
KR101722541B1 (en) 2009-05-06 2017-04-04 큐알엔에이, 인크. Treatment of tristetraproline(ttp) related diseases by inhibition of natural antisense transcript to ttp
WO2010132665A1 (en) 2009-05-15 2010-11-18 Yale University Gemm riboswitches, structure-based compound design with gemm riboswitches, and methods and compositions for use of and with gemm riboswitches
ES2664590T3 (en) 2009-05-18 2018-04-20 Curna, Inc. Treatment of diseases related to reprogramming factors by inhibition of the natural antisense transcript to a reprogramming factor
US8895527B2 (en) 2009-05-22 2014-11-25 Curna, Inc. Treatment of transcription factor E3 (TFE3) and insulin receptor substrate 2(IRS2) related diseases by inhibition of natural antisense transcript to TFE3
WO2010138806A2 (en) 2009-05-28 2010-12-02 Curna, Inc. Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
US8158601B2 (en) 2009-06-10 2012-04-17 Alnylam Pharmaceuticals, Inc. Lipid formulation
JP5944311B2 (en) 2009-06-16 2016-07-05 クルナ・インコーポレーテッド Treatment of collagen gene-related diseases by suppression of natural antisense transcripts against collagen genes
US8951981B2 (en) 2009-06-16 2015-02-10 Curna, Inc. Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
SI3305302T1 (en) 2009-06-17 2018-12-31 Biogen Ma Inc. Compositions and methods for modulation of smn2 splicing in a subject
JP6073133B2 (en) 2009-06-24 2017-02-01 クルナ・インコーポレーテッド Treatment of TNFR2-related diseases by suppression of natural antisense transcripts against tumor necrosis factor receptor 2 (TNFR2)
EP2446037B1 (en) 2009-06-26 2016-04-20 CuRNA, Inc. Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
CN102762731B (en) 2009-08-05 2018-06-22 库尔纳公司 By inhibiting to treat insulin gene (INS) relevant disease for the natural antisense transcript of insulin gene (INS)
WO2011020023A2 (en) 2009-08-14 2011-02-17 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
WO2011022420A1 (en) 2009-08-17 2011-02-24 Yale University Methylation biomarkers and methods of use
WO2011031482A2 (en) 2009-08-25 2011-03-17 Curna, Inc. Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
ES2599076T3 (en) 2009-09-02 2017-01-31 Genentech, Inc. Smoothened mutant and methods of use thereof
KR20120105446A (en) 2009-10-22 2012-09-25 제넨테크, 인크. Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
JP6147502B2 (en) 2009-10-27 2017-06-14 スウィフト バイオサイエンシーズ， インコーポレイテッド Polynucleotide primers and probes
KR20120136345A (en) 2009-10-30 2012-12-18 노오쓰웨스턴 유니버시티 Templated nanoconjugates
US20110110860A1 (en) 2009-11-02 2011-05-12 The Board Of Regents Of The University Of Texas System Modulation of ldl receptor gene expression with double-stranded rnas targeting the ldl receptor gene promoter
WO2011056215A1 (en) 2009-11-03 2011-05-12 Landers James P Versatile, visible method for detecting polymeric analytes
JP2013511285A (en) 2009-11-23 2013-04-04 スイフト・バイオサイエンシズ・インコーポレイテツド Device for extending single-stranded target molecules
AU2010324686B2 (en) 2009-11-30 2016-05-19 Genentech, Inc. Antibodies for treating and diagnosing tumors expressing SLC34A2 (TAT211 = SEQID2 )
ES2661813T3 (en) 2009-12-16 2018-04-04 Curna, Inc. Treatment of diseases related to membrane transcription factor peptidase, site 1 (mbtps1) by inhibition of the natural antisense transcript to the mbtps1 gene
JP5934106B2 (en) 2009-12-23 2016-06-15 カッパーアールエヌエー，インコーポレイテッド Treatment of HGF-related diseases by inhibition of natural antisense transcripts against hepatocyte growth factor (HGF)
CA2782375C (en) 2009-12-23 2023-10-31 Opko Curna, Llc Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
EP2519634B1 (en) 2009-12-29 2016-06-01 CuRNA, Inc. TREATMENT OF TUMOR PROTEIN 63 (p63) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO p63
US8921334B2 (en) 2009-12-29 2014-12-30 Curna, Inc. Treatment of nuclear respiratory factor 1 (NRF1) related diseases by inhibition of natural antisense transcript to NRF1
KR101878501B1 (en) 2010-01-04 2018-08-07 큐알엔에이, 인크. Treatment of interferon regulatory factor 8 (irf8) related diseases by inhibition of natural antisense transcript to irf8
KR101853509B1 (en) 2010-01-06 2018-04-30 큐알엔에이, 인크. Treatment of Pancreatic Developmental Gene Related Diseases By Inhibition of Natural Antisense Transcript to A Pancreatic Developmental Gene
ES2664866T3 (en) 2010-01-11 2018-04-23 Curna, Inc. Treatment of diseases related to sex hormone binding globulin (shbg) by inhibition of the natural antisense transcript to shbg
SG182365A1 (en) 2010-01-12 2012-08-30 Univ Yale Structured rna motifs and compounds and methods for their use
WO2011088391A2 (en) * 2010-01-14 2011-07-21 Haplomics, Inc. Predicting and reducing alloimmunogenicity of protein therapeutics
CN102782135A (en) 2010-01-25 2012-11-14 库尔纳公司 Treatment of RNase H1 related diseases by inhibition of natural antisense transcript to RNase H1
US9574191B2 (en) 2010-02-03 2017-02-21 The Board Of Regents Of The University Of Texas System Selective inhibition of polyglutamine protein expression
US20130028889A1 (en) 2010-02-04 2013-01-31 Ico Therapeutics Inc. Dosing regimens for treating and preventing ocular disorders using c-raf antisense
US8962586B2 (en) 2010-02-22 2015-02-24 Curna, Inc. Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1
WO2011105901A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 9 (c9) and uses thereof
WO2011105902A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 8-beta (c8-beta) and uses thereof
WO2011105900A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
US8877897B2 (en) 2010-02-23 2014-11-04 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2011112516A1 (en) 2010-03-08 2011-09-15 Ico Therapeutics Inc. Treating and preventing hepatitis c virus infection using c-raf kinase antisense oligonucleotides
US20130101512A1 (en) 2010-03-12 2013-04-25 Chad A. Mirkin Crosslinked polynucleotide structure
JP5860029B2 (en) 2010-03-29 2016-02-16 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． SiRNA therapy for transthyretin (TTR) related ocular amyloidosis
CN102858979B (en) 2010-04-09 2018-01-26 库尔纳公司 FGF21 relevant diseases are treated by suppressing the natural antisense transcript of FGF2 1 (FGF21)
WO2011133695A2 (en) 2010-04-20 2011-10-27 Swift Biosciences, Inc. Materials and methods for nucleic acid fractionation by solid phase entrapment and enzyme-mediated detachment
SI2563920T1 (en) 2010-04-29 2017-05-31 Ionis Pharmaceuticals, Inc. Modulation of transthyretin expression
WO2011139387A1 (en) 2010-05-03 2011-11-10 Opko Curna, Llc Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
BR112012028010A2 (en) 2010-05-03 2017-09-26 Genentech Inc isolated antibody, cell, isolated nucleic acid, method of identifying a first antibody that binds to a tat425 antigenic epitope attached to an antibody, methods of inhibiting cell growth, therapeutic treatment of determining the presence of a tat425 protein and diagnosing the presence of a tumor in a mammal
TWI586356B (en) 2010-05-14 2017-06-11 可娜公司 Treatment of par4 related diseases by inhibition of natural antisense transcript to par4
NO2576783T3 (en) 2010-05-26 2018-04-28
WO2011150226A1 (en) 2010-05-26 2011-12-01 Landers James P Method for detecting nucleic acids based on aggregate formation
CA2801066C (en) 2010-06-02 2021-02-09 Alnylam Pharmaceuticals, Inc. Compositions and methods directed to treating liver fibrosis
WO2011156434A2 (en) 2010-06-07 2011-12-15 Firefly Bioworks, Inc. Nucleic acid detection and quantification by post-hybridization labeling and universal encoding
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
WO2011163466A1 (en) 2010-06-23 2011-12-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Regulation of skin pigmentation by neuregulin-1 (nrg-1)
US8980860B2 (en) 2010-07-14 2015-03-17 Curna, Inc. Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG
WO2012021554A1 (en) 2010-08-09 2012-02-16 Yale University Cyclic di-gmp-ii riboswitches, motifs, and compounds, and methods for their use
DK2625197T3 (en) 2010-10-05 2016-10-03 Genentech Inc Smoothened MUTANT AND METHODS OF USING THE SAME
US8993533B2 (en) 2010-10-06 2015-03-31 Curna, Inc. Treatment of sialidase 4 (NEU4) related diseases by inhibition of natural antisense transcript to NEU4
CA2815212A1 (en) 2010-10-22 2012-04-26 Curna, Inc. Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
DK2633052T3 (en) 2010-10-27 2018-07-16 Curna Inc TREATMENT OF INTERFERON-RELATED DEVELOPMENT REGULATOR 1 (IFRD1) -RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPT TO IFRD1
WO2012064824A1 (en) 2010-11-09 2012-05-18 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes
KR102010598B1 (en) 2010-11-23 2019-08-13 큐알엔에이, 인크. Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog
US9150926B2 (en) 2010-12-06 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diagnosis and treatment of adrenocortical tumors using human microRNA-483
WO2012079046A2 (en) 2010-12-10 2012-06-14 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
WO2012078967A2 (en) 2010-12-10 2012-06-14 Alnylam Pharmaceuticals, Inc. Compositions and methods for increasing erythropoietin (epo) production
WO2012106508A1 (en) 2011-02-02 2012-08-09 Pfizer Inc. Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (ctgf)
WO2012106509A1 (en) 2011-02-02 2012-08-09 The Trustees Of Princeton University Sirtuin modulators as virus production modulators
CN105969773A (en) 2011-02-03 2016-09-28 米尔纳医疗股份有限公司 Synthetic mimics of MIR-124
BR112013019853A2 (en) 2011-02-03 2017-03-21 Mirna Therapeutics Inc mir-34 synthetic mimetics
EP3467109A1 (en) 2011-02-08 2019-04-10 Ionis Pharmaceuticals, Inc. Oligomeric compounds comprising bicyclic nucleotides and uses thereof
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
SG193923A1 (en) 2011-03-29 2013-11-29 Alnylam Pharmaceuticals Inc Compositions and methods for inhibiting expression of tmprss6 gene
EP3460064B8 (en) 2011-04-03 2024-03-20 The General Hospital Corporation d/b/a Massachusetts General Hospital Efficient protein expression in vivo using modified rna (mod-rna)
WO2012149154A1 (en) 2011-04-26 2012-11-01 Swift Biosciences, Inc. Polynucleotide primers and probes
WO2012151289A2 (en) 2011-05-02 2012-11-08 University Of Virginia Patent Foundation Method and system to detect aggregate formation on a substrate
WO2012151268A1 (en) 2011-05-02 2012-11-08 University Of Virginia Patent Foundation Method and system for high throughput optical and label free detection of analytes
JP6188686B2 (en) 2011-06-09 2017-08-30 カッパーアールエヌエー，インコーポレイテッド Treatment of FXN-related diseases by inhibition of natural antisense transcripts to frataxin (FXN)
EP2723351B1 (en) 2011-06-21 2018-02-14 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibition of expression of protein c (proc) genes
SG10201800715PA (en) 2011-06-21 2018-02-27 Alnylam Pharmaceuticals Inc Angiopoietin-like 3 (angptl3) irna compostions and methods of use thereof
MX344807B (en) 2011-06-21 2017-01-09 Alnylam Pharmaceuticals Inc Compositions and methods for inhibition of expression of apolipoprotein c-iii (apoc3) genes.
WO2012178033A2 (en) 2011-06-23 2012-12-27 Alnylam Pharmaceuticals, Inc. Serpina1 sirnas: compositions of matter and methods of treatment
EP2739735A2 (en) 2011-08-01 2014-06-11 Alnylam Pharmaceuticals, Inc. Method for improving the success rate of hematopoietic stem cell transplants
EP2742135B2 (en) 2011-08-11 2020-06-10 Ionis Pharmaceuticals, Inc. Linkage modified gapped oligomeric compounds and uses thereof
AU2012308302A1 (en) 2011-09-14 2014-03-20 Northwestern University Nanoconjugates able to cross the blood-brain barrier
WO2013040548A2 (en) 2011-09-17 2013-03-21 Yale University Fluoride-responsive riboswitchs, fluoride transporters, and methods of use
PT2766393T (en) 2011-10-14 2018-10-15 Hoffmann La Roche Anti-htra1 antibodies and methods of use
CN104114572A (en) 2011-12-16 2014-10-22 现代治疗公司 Modified nucleoside, nucleotide, and nucleic acid compositions
WO2013106358A1 (en) 2012-01-10 2013-07-18 Hussain M Mahmood Method of treating hyperlipidemia and atherosclerosis with mir-30c
CN104395480B (en) 2012-03-13 2018-01-30 斯威夫特生物科学公司 For the method and composition of size-controlled homopolymeric tailing to be carried out to substrate polynucleotide by nucleic acid polymerase
CN110438125A (en) 2012-03-15 2019-11-12 科纳公司 By inhibiting the natural antisense transcript of brain derived neurotrophic factor (BDNF) to treat BDNF related disease
CA2907072A1 (en) 2012-03-16 2013-09-19 Valerion Therapeutics, Llc Antisense conjugates for decreasing expression of dmpk
EP2833920A2 (en) 2012-04-02 2015-02-11 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
AU2013243949A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
US9133461B2 (en) 2012-04-10 2015-09-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the ALAS1 gene
EP2839006B1 (en) 2012-04-20 2018-01-03 Ionis Pharmaceuticals, Inc. Oligomeric compounds comprising bicyclic nucleotides and uses thereof
US9127274B2 (en) 2012-04-26 2015-09-08 Alnylam Pharmaceuticals, Inc. Serpinc1 iRNA compositions and methods of use thereof
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
US20140038182A1 (en) 2012-07-17 2014-02-06 Dna Logix, Inc. Cooperative primers, probes, and applications thereof
EP2897633B1 (en) 2012-09-18 2020-01-01 UTI Limited Partnership Treatment of pain by inhibition of usp5 de-ubiquitinase
WO2014059353A2 (en) 2012-10-11 2014-04-17 Isis Pharmaceuticals, Inc. Oligomeric compounds comprising bicyclic nucleosides and uses thereof
CA3201145A1 (en) 2012-10-26 2014-05-01 Geron Corporation C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders
CA2890207A1 (en) 2012-11-05 2014-05-08 Foundation Medicine, Inc. Novel ntrk1 fusion molecules and uses thereof
PL2922554T3 (en) 2012-11-26 2022-06-20 Modernatx, Inc. Terminally modified rna
BR112015013311A2 (en) 2012-12-07 2017-11-14 Haplomics Inc tolerance induction and factor 8 mutation repair
EP2946014A2 (en) 2013-01-17 2015-11-25 Moderna Therapeutics, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
US10980804B2 (en) 2013-01-18 2021-04-20 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
WO2014130922A1 (en) 2013-02-25 2014-08-28 Trustees Of Boston University Compositions and methods for treating fungal infections
US10398661B2 (en) 2013-02-28 2019-09-03 The Board Of Regents Of The University Of Texas System Methods for classifying a cancer as susceptible to TMEPAI-directed therapies and treating such cancers
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US10258698B2 (en) 2013-03-14 2019-04-16 Modernatx, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
WO2014160129A2 (en) 2013-03-14 2014-10-02 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
JP2016522679A (en) 2013-04-04 2016-08-04 プレジデント アンド フェローズ オブ ハーバード カレッジ Therapeutic use of genome editing with the CRISPR / Cas system
WO2014172698A1 (en) 2013-04-19 2014-10-23 Isis Pharmaceuticals, Inc. Compositions and methods for modulation nucleic acids through nonsense mediated decay
BR112015029139B1 (en) 2013-05-22 2022-07-12 Alnylam Pharmaceuticals, Inc DOUBLE-STRAND RNAI AGENT FOR INHIBITING SERPINA1 EXPRESSION IN A CELL, ITS USES, AS WELL AS PHARMACEUTICAL COMPOSITION AND IN VITRO METHOD OF INHIBITING SERPINA1 EXPRESSION IN A CELL
CN105452463B (en) 2013-05-22 2019-06-21 阿尔尼拉姆医药品有限公司 TMPRSS6 IRNA composition and its application method
US20160113911A1 (en) 2013-06-06 2016-04-28 The General Hospital Corporation Methods and compositions for the treatment of cancer
JP6869720B2 (en) 2013-06-13 2021-05-12 アンチセンス セラピューティクス リミテッド Combination therapy
AU2014287009B2 (en) 2013-07-11 2020-10-29 Modernatx, Inc. Compositions comprising synthetic polynucleotides encoding CRISPR related proteins and synthetic sgRNAs and methods of use
EP4079745A1 (en) 2013-08-08 2022-10-26 The Scripps Research Institute A method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
AU2014315287A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Chimeric polynucleotides
MX2016004230A (en) 2013-10-02 2016-10-21 Alnylam Pharmaceuticals Inc Compositions and methods for inhibiting expression of the lect2 gene.
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
SG11201602631XA (en) 2013-10-04 2016-05-30 Alnylam Pharmaceuticals Inc Compositions and methods for inhibiting expression of the alas1 gene
EP3055426B1 (en) 2013-10-09 2019-06-19 The United States of America as represented by The Secretary Department of Health and Human Services Detection of hepatitis delta virus (hdv) for the diagnosis and treatment of sjögren's syndrome and lymphoma
EP3502270B1 (en) 2013-10-21 2020-03-18 The General Hospital Corporation Methods relating to circulating tumor cell clusters and the treatment of cancer
WO2015066708A1 (en) 2013-11-04 2015-05-07 Northwestern University Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (sna)
CA2932122C (en) 2013-12-03 2022-04-19 Northwestern University Liposomal particles, methods of making same and uses thereof
CA2844640A1 (en) 2013-12-06 2015-06-06 The University Of British Columbia Method for treatment of castration-resistant prostate cancer
WO2015085183A2 (en) 2013-12-06 2015-06-11 Swift Biosciences, Inc. Cleavable competitor polynucleotides
AU2014362262B2 (en) 2013-12-12 2021-05-13 Alnylam Pharmaceuticals, Inc. Complement component iRNA compositions and methods of use thereof
CN106456694B (en) 2013-12-20 2020-06-30 通用医疗公司 Methods and assays relating to circulating tumor cells
DK3102197T3 (en) 2014-02-04 2018-11-19 Genentech Inc Smoothened mutant and methods for its use
CN113057959A (en) 2014-02-11 2021-07-02 阿尔尼拉姆医药品有限公司 Ketohexokinase (KHK) iRNA compositions and methods of use thereof
EP3129493B1 (en) 2014-04-09 2021-07-07 The Scripps Research Institute Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters
WO2015161170A2 (en) 2014-04-17 2015-10-22 Isis Pharmaceuticals, Inc. Compositions and methods for modulation of smn2 splicing in a subject
WO2015175510A1 (en) 2014-05-12 2015-11-19 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating a serpinc1-associated disorder
SG10202104570TA (en) 2014-05-22 2021-06-29 Alnylam Pharmaceuticals Inc Angiotensinogen (agt) irna compositions and methods of use thereof
CN106659758A (en) 2014-06-02 2017-05-10 儿童医疗中心有限公司 Methods and compositions for immunomodulation
CN106535876B (en) 2014-06-04 2020-09-11 埃克西奎雷股份有限公司 Multivalent delivery of immunomodulators through liposomal spherical nucleic acids for prophylactic or therapeutic applications
AU2015272128B2 (en) 2014-06-10 2021-10-28 Erasmus University Medical Center Rotterdam Antisense oligonucleotides useful in treatment of Pompe disease
EP4159741A1 (en) 2014-07-16 2023-04-05 ModernaTX, Inc. Method for producing a chimeric polynucleotide encoding a polypeptide having a triazole-containing internucleotide linkage
US9951327B1 (en) 2014-07-17 2018-04-24 Integrated Dna Technologies, Inc. Efficient and rapid method for assembling and cloning double-stranded DNA fragments
US20170210788A1 (en) 2014-07-23 2017-07-27 Modernatx, Inc. Modified polynucleotides for the production of intrabodies
US10653747B2 (en) 2014-07-31 2020-05-19 Uab Research Foundation ApoE mimetic peptides and higher potency to clear plasma cholesterol
EP3183007B1 (en) 2014-08-19 2020-06-17 Northwestern University Protein/oligonucleotide core-shell nanoparticle therapeutics
KR102631505B1 (en) 2014-08-29 2024-02-01 알닐람 파마슈티칼스 인코포레이티드 Methods of treating transthyretin(ttr) mediated amyloidosis
EP3185910A4 (en) 2014-08-29 2018-01-10 Children's Medical Center Corporation Methods and compositions for the treatment of cancer
WO2016033424A1 (en) 2014-08-29 2016-03-03 Genzyme Corporation Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
EP3191591A1 (en) 2014-09-12 2017-07-19 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting complement component c5 and methods of use thereof
US10533172B2 (en) 2014-09-18 2020-01-14 The University Of British Columbia Allele-specific therapy for huntington disease haplotypes
JOP20200115A1 (en) 2014-10-10 2017-06-16 Alnylam Pharmaceuticals Inc Compositions And Methods For Inhibition Of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) Gene Expression
WO2016061487A1 (en) 2014-10-17 2016-04-21 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
WO2016069694A2 (en) 2014-10-30 2016-05-06 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
JOP20200092A1 (en) 2014-11-10 2017-06-16 Alnylam Pharmaceuticals Inc HEPATITIS B VIRUS (HBV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
WO2016075584A1 (en) 2014-11-10 2016-05-19 Glaxosmithkline Intellectual Property (No.2) Limited Combination long acting compositions and methods for hepatitis c
US20170312297A1 (en) 2014-11-10 2017-11-02 Glaxosmithkline Intellectual Property (No. 2) Limited Long Acting Pharmaceutical Compositions For Hepatitis C
CA2968114A1 (en) 2014-11-17 2016-05-26 Alnylam Pharmaceuticals, Inc. Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
AU2015349680A1 (en) 2014-11-21 2017-06-08 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
US20160145547A1 (en) 2014-11-25 2016-05-26 Milliken & Company Film-Encased Cleaning Composition
WO2016100716A1 (en) 2014-12-18 2016-06-23 Vasant Jadhav Reversirtm compounds
EP3247988A4 (en) 2015-01-23 2018-12-19 Vanderbilt University A robust interferometer and methods of using same
AU2016219263B2 (en) 2015-02-13 2022-12-01 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof
KR20180020125A (en) 2015-03-27 2018-02-27 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Modified T cells and methods for their manufacture and use
WO2016164746A1 (en) 2015-04-08 2016-10-13 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the lect2 gene
WO2016201301A1 (en) 2015-06-12 2016-12-15 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
EP3310918B1 (en) 2015-06-18 2020-08-05 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
WO2016209862A1 (en) 2015-06-23 2016-12-29 Alnylam Pharmaceuticals, Inc. Glucokinase (gck) irna compositions and methods of use thereof
US10494632B2 (en) 2015-07-10 2019-12-03 Alnylam Pharmaceuticals, Inc. Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
JP2018520683A (en) 2015-07-17 2018-08-02 アルニラム ファーマスーティカルズ インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Multi-target single-body conjugates
US20180237774A1 (en) 2015-08-04 2018-08-23 Yeda Research And Development Co. Ltd. Methods of screening for riboswitches and attenuators
CN114525280A (en) 2015-09-02 2022-05-24 阿尔尼拉姆医药品有限公司 iRNA compositions of programmed cell death 1 ligand 1(PD-L1) and methods of use thereof
MX2018004509A (en) 2015-10-30 2018-08-01 Genentech Inc Anti-htra1 antibodies and methods of use thereof.
EP3370734B1 (en) 2015-11-05 2023-01-04 Children's Hospital Los Angeles Antisense oligo for use in treating acute myeloid leukemia
CA3007152A1 (en) 2015-12-07 2017-06-15 Erasmus University Medical Center Rotterdam Enzymatic replacement therapy and antisense therapy for pompe disease
US11761007B2 (en) 2015-12-18 2023-09-19 The Scripps Research Institute Production of unnatural nucleotides using a CRISPR/Cas9 system
WO2017132483A1 (en) 2016-01-29 2017-08-03 Vanderbilt University Free-solution response function interferometry
JP2019509721A (en) 2016-02-04 2019-04-11 キュリス，インコーポレイテッド Mutant smoothened and method of using the same
MA45295A (en) 2016-04-19 2019-02-27 Alnylam Pharmaceuticals Inc HIGH DENSITY LIPOPROTEIN BINDING PROTEIN (HDLBP / VIGILINE) RNA COMPOSITION AND METHODS FOR USING THEM
EP3469083A1 (en) 2016-06-10 2019-04-17 Alnylam Pharmaceuticals, Inc. COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
ES2929047T3 (en) 2016-06-24 2022-11-24 Scripps Research Inst Novel nucleoside triphosphate transporter and uses thereof
WO2018015936A2 (en) 2016-07-21 2018-01-25 Maxcyte, Inc. Methods and compositions for modifying genomic dna
NL2017295B1 (en) 2016-08-05 2018-02-14 Univ Erasmus Med Ct Rotterdam Antisense oligomeric compound for Pompe disease
NL2017294B1 (en) 2016-08-05 2018-02-14 Univ Erasmus Med Ct Rotterdam Natural cryptic exon removal by pairs of antisense oligonucleotides.
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
TWI788312B (en) 2016-11-23 2023-01-01 美商阿尼拉製藥公司 SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
KR20230166146A (en) 2016-12-16 2023-12-06 알닐람 파마슈티칼스 인코포레이티드 Methods for treating or preventing ttr-associated diseases using transthyretin(ttr) irna compositions
EP3571321A1 (en) 2017-01-23 2019-11-27 Regeneron Pharmaceuticals, Inc. Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof
WO2018183969A1 (en) 2017-03-30 2018-10-04 California Institute Of Technology Barcoded rapid assay platform for efficient analysis of candidate molecules and methods of making and using the platform
CN110913898B (en) 2017-04-18 2024-04-05 阿尔尼拉姆医药品有限公司 Methods of treating subjects having Hepatitis B Virus (HBV) infection
US20200131555A1 (en) 2017-07-11 2020-04-30 Synthorx, Inc. Incorporation of unnatural nucleotides and methods thereof
EP3652317A1 (en) 2017-07-13 2020-05-20 Alnylam Pharmaceuticals, Inc. Lactate dehydrogenase a (ldha) irna compositions and methods of use thereof
MX2020000387A (en) 2017-07-13 2020-08-17 Univ Northwestern General and direct method for preparing oligonucleotide-functiona lized metal-organic framework nanoparticles.
SG11202000939PA (en) 2017-08-03 2020-02-27 Synthorx Inc Cytokine conjugates for the treatment of proliferative and infectious diseases
WO2019060442A1 (en) 2017-09-19 2019-03-28 Alnylam Pharmaceuticals, Inc. Compositions and methods for treating transthyretin (ttr) mediated amyloidosis
AU2018360697A1 (en) 2017-11-01 2020-05-14 Alnylam Pharmaceuticals, Inc. Complement component C3 iRNA compositions and methods of use thereof
WO2019099610A1 (en) 2017-11-16 2019-05-23 Alnylam Pharmaceuticals, Inc. Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
WO2019100039A1 (en) 2017-11-20 2019-05-23 Alnylam Pharmaceuticals, Inc. Serum amyloid p component (apcs) irna compositions and methods of use thereof
MX2020006012A (en) 2017-12-18 2020-09-14 Alnylam Pharmaceuticals Inc High mobility group box-1 (hmgb1) irna compositions and methods of use thereof.
US20190233816A1 (en) 2018-01-26 2019-08-01 Massachusetts Institute Of Technology Structure-guided chemical modification of guide rna and its applications
SG11202007728QA (en) 2018-02-26 2020-09-29 Synthorx Inc Il-15 conjugates and uses thereof
JP2021520781A (en) 2018-04-06 2021-08-26 チルドレンズ メディカル センター コーポレーションＣｈｉｌｄｒｅｎ’Ｓ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ Ｃｏｒｐｏｒａｔｉｏｎ Compositions and Methods for Somatic Cell Reprogramming and Imprinting Modulation
TW202016301A (en) 2018-05-07 2020-05-01 美商阿里拉姆製藥股份有限公司 Extrahepatic delivery
TW202016304A (en) 2018-05-14 2020-05-01 美商阿尼拉製藥公司 Angiotensinogen (agt) irna compositions and methods of use thereof
TW202023574A (en) 2018-08-13 2020-07-01 美商阿尼拉製藥公司 Hepatitis b virus (hbv) dsrna agent compositions and methods of use thereof
WO2020037125A1 (en) 2018-08-16 2020-02-20 Alnylam Pharmaceuticals Inc. Compositions and methods for inhibiting expression of the lect2 gene
SG11202102531WA (en) 2018-09-14 2021-04-29 Univ Northwestern Programming protein polymerization with dna
AU2019344776A1 (en) 2018-09-18 2021-01-21 Alnylam Pharmaceuticals, Inc. Ketohexokinase (KHK) iRNA compositions and methods of use thereof
TW202028465A (en) 2018-09-28 2020-08-01 美商阿尼拉製藥公司 Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
US10913951B2 (en) 2018-10-31 2021-02-09 University of Pittsburgh—of the Commonwealth System of Higher Education Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
US20210332495A1 (en) 2018-12-06 2021-10-28 Northwestern University Protein Crystal Engineering Through DNA Hybridization Interactions
SI3897672T1 (en) 2018-12-20 2024-02-29 Humabs Biomed Sa Combination hbv therapy
EP3898977A1 (en) 2018-12-20 2021-10-27 Praxis Precision Medicines, Inc. Compositions and methods for the treatment of kcnt1 related disorders
MX2021008628A (en) 2019-01-16 2021-11-17 Genzyme Corp Serpinc1 irna compositions and methods of use thereof.
KR20210123299A (en) 2019-02-06 2021-10-13 신톡스, 인크. IL-2 conjugates and methods of use thereof
KR20220036914A (en) 2019-05-13 2022-03-23 비르 바이오테크놀로지, 인코포레이티드 Compositions and methods for treating hepatitis B virus (HBV) infection
CA3138915A1 (en) 2019-05-17 2020-11-26 Alnylam Pharmaceuticals, Inc. Oral delivery of oligonucleotides
BR112021025130A2 (en) 2019-06-14 2022-03-15 Scripps Research Inst Reagents and methods for replication, transcription and translation in semisynthetic organisms
WO2021022108A2 (en) 2019-08-01 2021-02-04 Alnylam Pharmaceuticals, Inc. CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
WO2021022109A1 (en) 2019-08-01 2021-02-04 Alnylam Pharmaceuticals, Inc. SERPIN FAMILY F MEMBER 2 (SERPINF2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
WO2021030522A1 (en) 2019-08-13 2021-02-18 Alnylam Pharmaceuticals, Inc. SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
KR20220047598A (en) 2019-08-15 2022-04-18 신톡스, 인크. Immuno-oncology Combination Therapy Using IL-2 Conjugates
US20210054040A1 (en) 2019-08-23 2021-02-25 Synthorx, Inc. Novel il-15 conjugates and uses thereof
WO2021046122A1 (en) 2019-09-03 2021-03-11 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the lect2 gene
KR20220061158A (en) 2019-09-10 2022-05-12 신톡스, 인크. IL-2 conjugates and methods of use for treating autoimmune diseases
WO2021067747A1 (en) 2019-10-04 2021-04-08 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing ugt1a1 gene expression
EP4045652A1 (en) 2019-10-18 2022-08-24 Alnylam Pharmaceuticals, Inc. Solute carrier family member irna compositions and methods of use thereof
BR112022007540A2 (en) 2019-10-22 2022-07-12 Alnylam Pharmaceuticals Inc COMPONENTS COMPLEMENTARY C3 IRNA COMPOSITIONS AND METHODS OF USE THEREOF
EP4051796A1 (en) 2019-11-01 2022-09-07 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing dnajb1-prkaca fusion gene expression
CA3155921A1 (en) 2019-11-01 2021-05-06 Alnylam Pharmaceuticals, Inc. Huntingtin (htt) irna agent compositions and methods of use thereof
JP2022554272A (en) 2019-11-04 2022-12-28 シンソークス， インコーポレイテッド Interleukin 10 conjugates and uses thereof
WO2021092145A1 (en) 2019-11-06 2021-05-14 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna composition and methods of use thereof for treating or preventing ttr-associated ocular diseases
KR20220110749A (en) 2019-11-06 2022-08-09 알닐람 파마슈티칼스 인코포레이티드 extrahepatic transmission
EP4061945A1 (en) 2019-11-22 2022-09-28 Alnylam Pharmaceuticals, Inc. Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
JP2023506181A (en) 2019-12-13 2023-02-15 アルナイラム ファーマシューティカルズ， インコーポレイテッド Human chromosome 9 open reading frame 72 (C9ORF72) iRNA agent compositions and methods of use thereof
WO2021126734A1 (en) 2019-12-16 2021-06-24 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
US20230057461A1 (en) 2020-01-27 2023-02-23 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Rab13 and net1 antisense oligonucleotides to treat metastatic cancer
WO2021154941A1 (en) 2020-01-31 2021-08-05 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
EP4103714A1 (en) 2020-02-10 2022-12-21 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing vegf-a expression
EP4107265A1 (en) 2020-02-18 2022-12-28 Alnylam Pharmaceuticals, Inc. Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
EP4114947A1 (en) 2020-03-05 2023-01-11 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
EP4114948A1 (en) 2020-03-06 2023-01-11 Alnylam Pharmaceuticals, Inc. Ketohexokinase (khk) irna compositions and methods of use thereof
EP4121534A1 (en) 2020-03-18 2023-01-25 Alnylam Pharmaceuticals, Inc. Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
JP2023519274A (en) 2020-03-26 2023-05-10 アルナイラム ファーマシューティカルズ， インコーポレイテッド CORONAVIRUS iRNA COMPOSITIONS AND METHODS OF USE THEREOF
WO2021202443A2 (en) 2020-03-30 2021-10-07 Alnylam Pharmaceucticals, Inc. Compositions and methods for silencing dnajc15 gene expression
JP2023520582A (en) 2020-04-06 2023-05-17 アルナイラム ファーマシューティカルズ， インコーポレイテッド Compositions and methods for silencing MYOC expression
EP4133077A1 (en) 2020-04-07 2023-02-15 Alnylam Pharmaceuticals, Inc. Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
EP4133076A1 (en) 2020-04-07 2023-02-15 Alnylam Pharmaceuticals, Inc. Angiotensin-converting enzyme 2 (ace2) irna compositions and methods of use thereof
US20230159933A1 (en) 2020-04-07 2023-05-25 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing scn9a expression
CN115955972A (en) 2020-04-27 2023-04-11 阿尔尼拉姆医药品有限公司 Apolipoprotein E (APOE) iRNA agent compositions and methods of use thereof
AU2021265813A1 (en) 2020-04-30 2022-11-10 Alnylam Pharmaceuticals, Inc. Complement factor B (CFB) iRNA compositions and methods of use thereof
EP4150078A1 (en) 2020-05-15 2023-03-22 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
CA3162416C (en) 2020-05-15 2023-07-04 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
WO2021231691A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
WO2021231680A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
EP4150086A1 (en) 2020-05-15 2023-03-22 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
WO2021231692A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of otoferlin (otof)
EP4150077A1 (en) 2020-05-15 2023-03-22 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
WO2021231679A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
US20230183707A1 (en) 2020-05-21 2023-06-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting marc1 gene expression
AR122534A1 (en) 2020-06-03 2022-09-21 Triplet Therapeutics Inc METHODS FOR THE TREATMENT OF NUCLEOTIDE REPEAT EXPANSION DISORDERS ASSOCIATED WITH MSH3 ACTIVITY
JP2023530234A (en) 2020-06-05 2023-07-14 ザ・ブロード・インスティテュート・インコーポレイテッド Compositions and methods for treating neoplasms
EP4162050A1 (en) 2020-06-09 2023-04-12 Alnylam Pharmaceuticals, Inc. Rnai compositions and methods of use thereof for delivery by inhalation
CA3184289A1 (en) 2020-06-18 2021-12-23 Alnylam Pharmaceuticals, Inc. Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof
KR20230042023A (en) 2020-06-24 2023-03-27 비르 바이오테크놀로지, 인코포레이티드 Engineered hepatitis B virus neutralizing antibodies and uses thereof
AU2021296622A1 (en) 2020-06-25 2023-02-23 Synthorx, Inc. Immuno oncology combination therapy with IL-2 conjugates and anti-EGFR antibodies
WO2022011214A1 (en) 2020-07-10 2022-01-13 Alnylam Pharmaceuticals, Inc. Circular sirnas
EP4217489A1 (en) 2020-09-24 2023-08-02 Alnylam Pharmaceuticals, Inc. Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
WO2022076291A1 (en) 2020-10-05 2022-04-14 Alnylam Pharmaceuticals, Inc. G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof
BR112023006364A2 (en) 2020-10-09 2023-05-09 Synthorx Inc IMMUNO-ONCOLOGY COMBINATION THERAPY WITH IL-2 AND PEMBROLIZUMAB CONJUGATES
KR20230084204A (en) 2020-10-09 2023-06-12 신톡스, 인크. Immuno-oncology therapy using IL-2 conjugates
WO2022087041A1 (en) 2020-10-21 2022-04-28 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating primary hyperoxaluria
WO2022087329A1 (en) 2020-10-23 2022-04-28 Alnylam Pharmaceuticals, Inc. Mucin 5b (muc5b) irna compositions and methods of use thereof
EP4244355A1 (en) 2020-11-13 2023-09-20 Alnylam Pharmaceuticals, Inc. Coagulation factor v (f5) irna compositions and methods of use thereof
EP4256053A1 (en) 2020-12-01 2023-10-11 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
WO2022125490A1 (en) 2020-12-08 2022-06-16 Alnylam Pharmaceuticals, Inc. Coagulation factor x (f10) irna compositions and methods of use thereof
JP2024501288A (en) 2020-12-23 2024-01-11 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー Compositions of modified TREM and uses thereof
WO2022147223A2 (en) 2020-12-31 2022-07-07 Alnylam Pharmaceuticals, Inc. 2'-modified nucleoside based oligonucleotide prodrugs
WO2022147214A2 (en) 2020-12-31 2022-07-07 Alnylam Pharmaceuticals, Inc. Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
EP4274896A1 (en) 2021-01-05 2023-11-15 Alnylam Pharmaceuticals, Inc. Complement component 9 (c9) irna compositions and methods of use thereof
WO2022174101A1 (en) 2021-02-12 2022-08-18 Synthorx, Inc. Skin cancer combination therapy with il-2 conjugates and cemiplimab
KR20230146048A (en) 2021-02-12 2023-10-18 알닐람 파마슈티칼스 인코포레이티드 Superoxide dismutase 1 (SOD1) IRNA compositions and methods of using them to treat or prevent superoxide dismutase 1- (SOD1-)-related neurodegenerative diseases
EP4291243A1 (en) 2021-02-12 2023-12-20 Synthorx, Inc. Lung cancer combination therapy with il-2 conjugates and an anti-pd-1 antibody or antigen-binding fragment thereof
EP4298220A1 (en) 2021-02-25 2024-01-03 Alnylam Pharmaceuticals, Inc. Prion protein (prnp) irna compositions and methods of use thereof
IL305153A (en) 2021-02-26 2023-10-01 Alnylam Pharmaceuticals Inc KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
IL305418A (en) 2021-03-04 2023-10-01 Alnylam Pharmaceuticals Inc Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
WO2022192038A1 (en) 2021-03-12 2022-09-15 Northwestern University Antiviral vaccines using spherical nucleic acids
WO2022192519A1 (en) 2021-03-12 2022-09-15 Alnylam Pharmaceuticals, Inc. Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
IL307239A (en) 2021-03-29 2023-11-01 Alnylam Pharmaceuticals Inc Huntingtin (htt) irna agent compositions and methods of use thereof
AU2022249318A1 (en) 2021-03-31 2023-10-12 Entrada Therapeutics, Inc. Cyclic cell penetrating peptides
WO2022212153A1 (en) 2021-04-01 2022-10-06 Alnylam Pharmaceuticals, Inc. Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
BR112023022284A2 (en) 2021-04-26 2023-12-26 Alnylam Pharmaceuticals Inc COMPOSITIONS OF TRANSMEMBRANE PROTEASE IRNA, SERINE 6 (TMPRSS6) AND METHODS OF USE THEREOF
EP4330396A1 (en) 2021-04-29 2024-03-06 Alnylam Pharmaceuticals, Inc. Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
EP4334448A1 (en) 2021-05-03 2024-03-13 Alnylam Pharmaceuticals, Inc. Compositions and methods for treating transthyretin (ttr) mediated amyloidosis
EP4337263A1 (en) 2021-05-10 2024-03-20 Entrada Therapeutics, Inc. Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
EP4337261A2 (en) 2021-05-10 2024-03-20 Entrada Therapeutics, Inc. Compositions and methods for modulating mrna splicing
AU2022271873A1 (en) 2021-05-10 2024-01-04 Entrada Therapeutics, Inc. Compositions and methods for intracellular therapeutics
WO2022245583A1 (en) 2021-05-18 2022-11-24 Alnylam Pharmaceuticals, Inc. Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
WO2022246023A1 (en) 2021-05-20 2022-11-24 Korro Bio, Inc. Methods and compositions for adar-mediated editing
WO2022256283A2 (en) 2021-06-01 2022-12-08 Korro Bio, Inc. Methods for restoring protein function using adar
TW202317762A (en) 2021-06-02 2023-05-01 美商艾拉倫製藥股份有限公司 Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
TW202313117A (en) 2021-06-03 2023-04-01 美商欣爍克斯公司 Head and neck cancer combination therapy comprising an il-2 conjugate and cetuximab
TW202308663A (en) 2021-06-04 2023-03-01 美商艾拉倫製藥股份有限公司 Human chromosome 9 open reading frame 72 (c9orf72) irna agent compositions and methods of use thereof
AR126070A1 (en) 2021-06-08 2023-09-06 Alnylam Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING STARGARDT DISEASE AND/OR DISORDERS ASSOCIATED WITH RETINOL BORDER PROTEIN 4 (RBP4)
WO2022271818A1 (en) 2021-06-23 2022-12-29 Entrada Therapeutics, Inc. Antisense compounds and methods for targeting cug repeats
WO2023278410A1 (en) 2021-06-29 2023-01-05 Korro Bio, Inc. Methods and compositions for adar-mediated editing
US20230194709A9 (en) 2021-06-29 2023-06-22 Seagate Technology Llc Range information detection using coherent pulse sets with selected waveform characteristics
WO2023283403A2 (en) 2021-07-09 2023-01-12 Alnylam Pharmaceuticals, Inc. Bis-rnai compounds for cns delivery
TW202333748A (en) 2021-07-19 2023-09-01 美商艾拉倫製藥股份有限公司 Methods and compositions for treating subjects having or at risk of developing a non-primary hyperoxaluria disease or disorder
KR20240036041A (en) 2021-07-21 2024-03-19 알닐람 파마슈티칼스 인코포레이티드 Metabolic Disorder-Associated Target Gene iRNA Composition and Methods of Using Same
IL309905A (en) 2021-07-23 2024-03-01 Alnylam Pharmaceuticals Inc Beta-catenin (ctnnb1) irna compositions and methods of use thereof
WO2023009687A1 (en) 2021-07-29 2023-02-02 Alnylam Pharmaceuticals, Inc. 3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof
WO2023014677A1 (en) 2021-08-03 2023-02-09 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna compositions and methods of use thereof
TW202337474A (en) 2021-08-04 2023-10-01 美商艾拉倫製藥股份有限公司 Irna compositions and methods for silencing angiotensinogen (agt)
TW202334413A (en) 2021-08-13 2023-09-01 美商艾拉倫製藥股份有限公司 Factor xii (f12) irna compositions and methods of use thereof
IL311139A (en) 2021-09-01 2024-04-01 Entrada Therapeutics Inc Compounds and methods for skipping exon 44 in duchenne muscular dystrophy
WO2023044370A2 (en) 2021-09-17 2023-03-23 Alnylam Pharmaceuticals, Inc. Irna compositions and methods for silencing complement component 3 (c3)
WO2023044094A1 (en) 2021-09-20 2023-03-23 Alnylam Pharmaceuticals, Inc. Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
CA3234887A1 (en) 2021-10-15 2023-04-20 Alnylam Pharmaceuticals, Inc. Extra-hepatic delivery irna compositions and methods of use thereof
WO2023069603A1 (en) 2021-10-22 2023-04-27 Korro Bio, Inc. Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
AR127477A1 (en) 2021-10-29 2024-01-31 Alnylam Pharmaceuticals Inc COMPOSITIONS OF RNAi AGAINST COMPLEMENT FACTOR B (CFB) AND METHODS OF USE THEREOF
TW202334418A (en) 2021-10-29 2023-09-01 美商艾拉倫製藥股份有限公司 Huntingtin (htt) irna agent compositions and methods of use thereof
WO2023092060A1 (en) 2021-11-18 2023-05-25 Cornell University Microrna-dependent mrna switches for tissue-specific mrna-based therapies
WO2023122573A1 (en) 2021-12-20 2023-06-29 Synthorx, Inc. Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
WO2023122750A1 (en) 2021-12-23 2023-06-29 Synthorx, Inc. Cancer combination therapy with il-2 conjugates and cetuximab
WO2023141314A2 (en) 2022-01-24 2023-07-27 Alnylam Pharmaceuticals, Inc. Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
WO2023220744A2 (en) 2022-05-13 2023-11-16 Alnylam Pharmaceuticals, Inc. Single-stranded loop oligonucleotides
WO2024006999A2 (en) 2022-06-30 2024-01-04 Alnylam Pharmaceuticals, Inc. Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
WO2024039776A2 (en) 2022-08-18 2024-02-22 Alnylam Pharmaceuticals, Inc. Universal non-targeting sirna compositions and methods of use thereof
WO2024059165A1 (en) 2022-09-15 2024-03-21 Alnylam Pharmaceuticals, Inc. 17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
WO2024073732A1 (en) 2022-09-30 2024-04-04 Alnylam Pharmaceuticals, Inc. Modified double-stranded rna agents

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1978953A (en) * 1928-10-17 1934-10-30 Du Pont Method of preparing an alkali metal perborate
DE548432C (en) * 1928-10-17 1932-04-12 Degussa Production of a perborate
US3327684A (en) * 1963-03-11 1967-06-27 Fairchild Camera Instr Co Masking apparatus for spray coating
FR2226460B1 (en) * 1973-04-20 1976-12-17 Interox
JPS5315717B2 (en) * 1973-12-20 1978-05-26
DE2652776A1 (en) * 1975-05-13 1978-05-24 Interox Chemicals Ltd Stabilised sodium percarbonate mfr. - by precipitating in presence of silicate, then increasing the silicate content of the mother liquor
LU72575A1 (en) * 1975-05-23 1977-02-10
DE2651442C3 (en) * 1976-11-11 1979-11-15 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Sodium Percarbonate Particles
DE2712139C3 (en) * 1977-03-19 1982-05-19 Degussa Ag, 6000 Frankfurt Sodium percarbonate layer particles
DE2810379C3 (en) * 1978-03-10 1980-12-11 Degussa Ag, 6000 Frankfurt Process for the production of stabilized sodium percarbonate
US4156039A (en) * 1976-11-11 1979-05-22 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler Sodium percarbonate particles (A)
LU76548A1 (en) * 1977-01-10 1978-09-18
DE2800760C2 (en) * 1978-01-09 1983-01-27 Degussa Ag, 6000 Frankfurt Process for the production of sodium percarbonate from a soda solution or suspension
GB1575792A (en) * 1978-01-10 1980-10-01 Interox Peroxygen compounds
GB2123044B (en) * 1982-06-10 1986-02-05 Kao Corp Bleaching detergent composition
DE3321082C2 (en) * 1982-06-10 1996-08-22 Kao Corp Bleach Cleaner
EP0117578A3 (en) * 1983-02-23 1985-01-30 Shionogi & Co., Ltd. Azole-substituted alcohol derivatives
DE3784787T2 (en) * 1986-06-23 1994-01-20 Du Pont Merck Pharma Fungicidal carbinols.
US4952232A (en) * 1987-04-29 1990-08-28 E. I. Du Pont De Nemours And Company Antifungal carbinols
DE3720277A1 (en) * 1987-06-19 1988-12-29 Degussa METHOD FOR REDUCING THE TENSION TO BAKING UP PARTICULATE ACTIVE OXYGEN COMPOUNDS
DE3813874A1 (en) * 1987-07-10 1989-01-19 Bayer Ag HYDROXYALKYL-AZOLYL DERIVATIVES
DE3921481A1 (en) * 1989-06-30 1991-01-03 Bayer Ag HYDROXYETHYL-CYCLOPROPYL-AZOLYL DERIVATIVES
WO1991012000A1 (en) * 1990-02-13 1991-08-22 E.I. Du Pont De Nemours And Company ANILINE DERIVATIVES OF α-STYRYL CARBINOLS AS ANTIFUNGAL AGENTS
JP2636496B2 (en) * 1990-11-21 1997-07-30 花王 株式会社 Stable sodium percarbonate particles and method for producing the same

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