CA2155330A1 - Human neuronal nicotinic acetylcholine receptor compositions and methods employing same - Google Patents
Human neuronal nicotinic acetylcholine receptor compositions and methods employing sameInfo
- Publication number
- CA2155330A1 CA2155330A1 CA002155330A CA2155330A CA2155330A1 CA 2155330 A1 CA2155330 A1 CA 2155330A1 CA 002155330 A CA002155330 A CA 002155330A CA 2155330 A CA2155330 A CA 2155330A CA 2155330 A1 CA2155330 A1 CA 2155330A1
- Authority
- CA
- Canada
- Prior art keywords
- alpha
- subunits
- beta
- acetylcholine receptor
- nicotinic acetylcholine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Abstract
Nucleic acids encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said nucleic acids, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha.4 and .alpha.7) and beta subunits (specifically (.beta.4) are provided. In addition, combinations of subunits (i.e., .alpha.1, .alpha.2, .alpha.3, .alpha.4, and/or .alpha.7 subunits in combination with .beta.4 subunits; or (.beta.2, .beta.3 and/or .beta.4 subunits in combination with .alpha.4 and/or .alpha.7 subunits) are provided.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2803193A | 1993-03-08 | 1993-03-08 | |
US08/028,031 | 1993-03-08 | ||
PCT/US1994/002447 WO1994020617A2 (en) | 1993-03-08 | 1994-03-08 | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2155330A1 true CA2155330A1 (en) | 1994-09-15 |
CA2155330C CA2155330C (en) | 2002-01-29 |
Family
ID=21841175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002155330A Expired - Fee Related CA2155330C (en) | 1993-03-08 | 1994-03-08 | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
Country Status (10)
Country | Link |
---|---|
US (5) | US6022704A (en) |
EP (2) | EP1508614A1 (en) |
JP (2) | JP3628691B2 (en) |
AT (1) | ATE279516T1 (en) |
AU (1) | AU694424B2 (en) |
CA (1) | CA2155330C (en) |
DE (1) | DE69434067T2 (en) |
ES (1) | ES2229216T3 (en) |
GB (1) | GB2286397C (en) |
WO (1) | WO1994020617A2 (en) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6936457B1 (en) * | 1990-04-03 | 2005-08-30 | Merck & Co., Inc. | DNA ENCODING HUMAN α AND β SUBUNITS OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR, CELLS TRANSFORMED THEREWITH, AND RECOMBINANT CELL LINE EXPRESSING A HUMAN α AND β SUBUNIT OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR |
ATE279516T1 (en) | 1993-03-08 | 2004-10-15 | Merck & Co Inc | HUMAN NEURONAL NICOTINE-ACETYLCHOLINE RECEPTOR COMPOUNDS AND METHODS OF THEIR USE |
US6485967B1 (en) * | 1995-06-07 | 2002-11-26 | Merck & Co., Inc. | Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid |
CA2279675A1 (en) * | 1995-12-15 | 1997-06-16 | Enzo Therapeutics, Inc. | Property effecting and/or property exhibiting constructs for localizing a nucleic acid construct within a cell for therapeutic and diagnostic uses |
US6323000B2 (en) * | 1996-12-20 | 2001-11-27 | Clark A. Briggs | Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof |
WO1998058074A2 (en) * | 1997-06-13 | 1998-12-23 | Allelix Biopharmaceuticals Inc. | Assay methods and compositions useful for measuring receptor ligand binding |
US6875606B1 (en) * | 1997-10-23 | 2005-04-05 | The United States Of America As Represented By The Department Of Veterans Affairs | Human α-7 nicotinic receptor promoter |
US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
EP0953637A3 (en) * | 1998-03-24 | 2001-04-25 | Smithkline Beecham Plc | Acetylcholine receptor |
US6252132B1 (en) | 1998-11-02 | 2001-06-26 | Institut Pasteur | Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor |
US6693172B1 (en) | 1999-05-27 | 2004-02-17 | Pharmacia And Upjohn Company | Double mutant alpha-7 nicotinic acetylcholine receptor |
JP2003501022A (en) * | 1999-05-27 | 2003-01-14 | ファルマシア・アンド・アップジョン・カンパニー | Method for measuring ion channel conductance and composition thereof |
GB9913248D0 (en) * | 1999-06-09 | 1999-08-04 | Babraham Inst | Recombinant nematode nicotinic receptor and uses |
US6737270B1 (en) | 1999-12-07 | 2004-05-18 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Long-term three dimensional tissue culture system |
US20030096411A1 (en) * | 1999-12-07 | 2003-05-22 | George Michalopoulos | Novel long-term three-dimensional tissue culture system |
DE19959582A1 (en) * | 1999-12-10 | 2001-06-13 | Bayer Ag | Nucleic acids encoding new acetylcholine receptor beta subunits of insects |
GB2364385B (en) * | 2000-03-29 | 2002-08-14 | Synaptica Ltd | Alpha 7 nicotinic receptor screening assays |
WO2002016357A2 (en) | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
EP1381603A2 (en) | 2000-08-18 | 2004-01-21 | PHARMACIA & UPJOHN COMPANY | Quinuclidine-substituedaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands ) |
US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
WO2002017358A2 (en) | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists) |
AU2001284646A1 (en) | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
AU2002215977A1 (en) * | 2000-10-31 | 2002-05-15 | Bayer Aktiengesellschaft | Regulation of human serotonin receptor precursor |
PE20021019A1 (en) | 2001-04-19 | 2002-11-13 | Upjohn Co | SUBSTITUTED AZABYCLE GROUPS |
IL160651A0 (en) * | 2001-08-31 | 2004-07-25 | Agensys Inc | Nucleic acid and correspondidng protein entitled 205pib5 and pharmaceutical compositions containing the same |
JP2005532029A (en) * | 2001-09-12 | 2005-10-27 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | Human ion channel |
US7229779B2 (en) | 2001-09-18 | 2007-06-12 | Abbott Laboratories | Variant human α7 acetylcholine receptor subunit, and methods of production and use thereof |
US20060126682A1 (en) * | 2001-10-08 | 2006-06-15 | Geola Technologies Ltd. | Pulsed multiple colour laser system |
WO2003095976A2 (en) * | 2002-05-09 | 2003-11-20 | Memory Pharmaceuticals Corporation | Qm-7 and qt-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells |
EP1542999A1 (en) * | 2002-08-01 | 2005-06-22 | Pharmacia & Upjohn Company LLC | 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity |
US20040151729A1 (en) * | 2002-10-28 | 2004-08-05 | George Michalopoulos | Novel long-term three-dimensional culture system |
US20060142188A1 (en) * | 2003-02-14 | 2006-06-29 | Memory Pharmaceuticals Corporation | Monkey alpha-7 nicotinic acetylcholine receptor and methods of use thereof |
US7576878B2 (en) * | 2003-04-03 | 2009-08-18 | Hewlett-Packard Development Company, L.P. | Enhanced management of raster image processing resources |
WO2005030145A2 (en) * | 2003-09-24 | 2005-04-07 | Targacept, Inc. | Composition and pharmacology of novel alpha-6-containing nicotinic acetylcholine receptors |
US20070249011A1 (en) * | 2004-03-04 | 2007-10-25 | Riken | Method for Screening Fungus-Specific Antimicrobial Agent and Kit Therefor |
EP1684324B1 (en) * | 2005-01-20 | 2011-01-19 | LG Electronics Inc. | Plasma display panel |
CN101180543B (en) * | 2005-02-23 | 2014-06-18 | 美国陶氏益农公司 | Novel assays utilizing nicotinic acetylcholine receptor subunits |
US7879913B2 (en) * | 2005-06-28 | 2011-02-01 | Catholic Healthcare West | Iptakalim hydrochloride for decreasing nicotine use |
WO2018057837A1 (en) * | 2016-09-23 | 2018-03-29 | Ionis Pharmaceuticals, Inc. | Gene therapy and targeted delivery of conjugated compounds |
US10538571B2 (en) * | 2017-11-27 | 2020-01-21 | Coda Biotherapeutics, Inc. | Compositions and methods for neurological diseases |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
US4855231A (en) * | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
US4837148A (en) * | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
US4882279A (en) * | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
US4859609A (en) * | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
US5024939A (en) * | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
US4929555A (en) * | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
CA1341554C (en) | 1988-03-18 | 2007-10-09 | The Salk Institute For Biological Studies | Neuronal nicotinic acetylcholine receptor compositions and assay |
US5449606A (en) * | 1988-03-18 | 1995-09-12 | The Salk Institute For Biological Studies | DNA encoding neuronal nicotinic acetylcholine receptor compositions containing the beta 4 subunit |
CA1341170C (en) * | 1988-04-04 | 2001-01-16 | Steven B. Ellis | Calcium channel compositions and methods |
US5386025A (en) * | 1990-02-20 | 1995-01-31 | The Salk Institute Biotechnology/Industrial Associates | Calcium channel compositions and methods |
ATE182360T1 (en) * | 1989-03-14 | 1999-08-15 | Salk Inst For Biological Studi | NEURONAL NICOTINA ACETYLCHOLINE RECEPTOR COMPOSITIONS CONTAINING THE BETA-4 SUBUNIT |
CA2067216A1 (en) * | 1989-10-25 | 1991-04-26 | Cary Alan Weinberger | Receptor infection assay |
US5091518A (en) * | 1989-11-16 | 1992-02-25 | The Salk Institute For Biological Studies | Beta retinoic acid response elements compositions and assays |
US5369028A (en) * | 1990-04-03 | 1994-11-29 | The Salk Institute Biotechnology/Industrial Associates, Inc. | DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same |
US5401629A (en) * | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
ATE279516T1 (en) | 1993-03-08 | 2004-10-15 | Merck & Co Inc | HUMAN NEURONAL NICOTINE-ACETYLCHOLINE RECEPTOR COMPOUNDS AND METHODS OF THEIR USE |
AU1091595A (en) | 1993-11-08 | 1995-05-29 | Salk Institute Biotechnology/Industrial Associates, Inc., The | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
-
1994
- 1994-03-08 AT AT94912758T patent/ATE279516T1/en not_active IP Right Cessation
- 1994-03-08 EP EP04077712A patent/EP1508614A1/en not_active Withdrawn
- 1994-03-08 ES ES94912758T patent/ES2229216T3/en not_active Expired - Lifetime
- 1994-03-08 JP JP52024094A patent/JP3628691B2/en not_active Expired - Fee Related
- 1994-03-08 WO PCT/US1994/002447 patent/WO1994020617A2/en active IP Right Grant
- 1994-03-08 CA CA002155330A patent/CA2155330C/en not_active Expired - Fee Related
- 1994-03-08 GB GB9503688A patent/GB2286397C/en not_active Expired - Fee Related
- 1994-03-08 AU AU65173/94A patent/AU694424B2/en not_active Ceased
- 1994-03-08 DE DE69434067T patent/DE69434067T2/en not_active Expired - Fee Related
- 1994-03-08 EP EP94912758A patent/EP0688361B1/en not_active Expired - Lifetime
-
1995
- 1995-06-05 US US08/467,574 patent/US6022704A/en not_active Expired - Fee Related
- 1995-06-05 US US08/466,589 patent/US5837489A/en not_active Expired - Fee Related
-
1996
- 1996-07-16 US US08/700,636 patent/US5910582A/en not_active Expired - Fee Related
-
1998
- 1998-12-21 US US09/217,345 patent/US6303753B1/en not_active Expired - Fee Related
-
2001
- 2001-06-27 US US09/892,985 patent/US6664375B2/en not_active Expired - Fee Related
-
2004
- 2004-02-05 JP JP2004029558A patent/JP2004194667A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP3628691B2 (en) | 2005-03-16 |
GB2286397B (en) | 1997-09-10 |
EP1508614A1 (en) | 2005-02-23 |
US5910582A (en) | 1999-06-08 |
JP2004194667A (en) | 2004-07-15 |
EP0688361A1 (en) | 1995-12-27 |
US6303753B1 (en) | 2001-10-16 |
JPH08507441A (en) | 1996-08-13 |
CA2155330C (en) | 2002-01-29 |
WO1994020617A3 (en) | 1994-10-27 |
EP0688361B1 (en) | 2004-10-13 |
WO1994020617A2 (en) | 1994-09-15 |
DE69434067T2 (en) | 2006-03-02 |
US6022704A (en) | 2000-02-08 |
US20020111463A1 (en) | 2002-08-15 |
GB2286397A (en) | 1995-08-16 |
GB9503688D0 (en) | 1995-04-12 |
AU6517394A (en) | 1994-09-26 |
ATE279516T1 (en) | 2004-10-15 |
AU694424B2 (en) | 1998-07-23 |
ES2229216T3 (en) | 2005-04-16 |
GB2286397C (en) | 1997-09-10 |
US6664375B2 (en) | 2003-12-16 |
DE69434067D1 (en) | 2004-11-18 |
US5837489A (en) | 1998-11-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |