CA2155330A1 - Human neuronal nicotinic acetylcholine receptor compositions and methods employing same - Google Patents

Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Info

Publication number
CA2155330A1
CA2155330A1 CA002155330A CA2155330A CA2155330A1 CA 2155330 A1 CA2155330 A1 CA 2155330A1 CA 002155330 A CA002155330 A CA 002155330A CA 2155330 A CA2155330 A CA 2155330A CA 2155330 A1 CA2155330 A1 CA 2155330A1
Authority
CA
Canada
Prior art keywords
alpha
subunits
beta
acetylcholine receptor
nicotinic acetylcholine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002155330A
Other languages
French (fr)
Other versions
CA2155330C (en
Inventor
Kathryn J. Elliott
Steven B. Ellis
Michael M. Harpold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Kathryn J. Elliott
Steven B. Ellis
Michael M. Harpold
The Salk Institute Biotechnology/Industrial Associates, Inc.
Sibia Neurosciences, Inc.
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold, The Salk Institute Biotechnology/Industrial Associates, Inc., Sibia Neurosciences, Inc., Merck & Co., Inc. filed Critical Kathryn J. Elliott
Publication of CA2155330A1 publication Critical patent/CA2155330A1/en
Application granted granted Critical
Publication of CA2155330C publication Critical patent/CA2155330C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Abstract

Nucleic acids encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said nucleic acids, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha.4 and .alpha.7) and beta subunits (specifically (.beta.4) are provided. In addition, combinations of subunits (i.e., .alpha.1, .alpha.2, .alpha.3, .alpha.4, and/or .alpha.7 subunits in combination with .beta.4 subunits; or (.beta.2, .beta.3 and/or .beta.4 subunits in combination with .alpha.4 and/or .alpha.7 subunits) are provided.
CA002155330A 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same Expired - Fee Related CA2155330C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2803193A 1993-03-08 1993-03-08
US08/028,031 1993-03-08
PCT/US1994/002447 WO1994020617A2 (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Publications (2)

Publication Number Publication Date
CA2155330A1 true CA2155330A1 (en) 1994-09-15
CA2155330C CA2155330C (en) 2002-01-29

Family

ID=21841175

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002155330A Expired - Fee Related CA2155330C (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Country Status (10)

Country Link
US (5) US6022704A (en)
EP (2) EP0688361B1 (en)
JP (2) JP3628691B2 (en)
AT (1) ATE279516T1 (en)
AU (1) AU694424B2 (en)
CA (1) CA2155330C (en)
DE (1) DE69434067T2 (en)
ES (1) ES2229216T3 (en)
GB (1) GB2286397B (en)
WO (1) WO1994020617A2 (en)

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US6875606B1 (en) * 1997-10-23 2005-04-05 The United States Of America As Represented By The Department Of Veterans Affairs Human α-7 nicotinic receptor promoter
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
EP0953637A3 (en) * 1998-03-24 2001-04-25 Smithkline Beecham Plc Acetylcholine receptor
US6252132B1 (en) 1998-11-02 2001-06-26 Institut Pasteur Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor
US6693172B1 (en) 1999-05-27 2004-02-17 Pharmacia And Upjohn Company Double mutant alpha-7 nicotinic acetylcholine receptor
WO2000073431A2 (en) * 1999-05-27 2000-12-07 Pharmacia & Upjohn Company Methods and compositions for measuring ion channel conductance
GB9913248D0 (en) * 1999-06-09 1999-08-04 Babraham Inst Recombinant nematode nicotinic receptor and uses
US20030096411A1 (en) * 1999-12-07 2003-05-22 George Michalopoulos Novel long-term three-dimensional tissue culture system
US6737270B1 (en) 1999-12-07 2004-05-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education Long-term three dimensional tissue culture system
DE19959582A1 (en) * 1999-12-10 2001-06-13 Bayer Ag Nucleic acids encoding new acetylcholine receptor beta subunits of insects
GB2364385B (en) * 2000-03-29 2002-08-14 Synaptica Ltd Alpha 7 nicotinic receptor screening assays
JP2004506735A (en) 2000-08-18 2004-03-04 ファルマシア・アンド・アップジョン・カンパニー Quinuclidine-substituted aryl compounds for disease treatment
US6486172B2 (en) 2000-08-18 2002-11-26 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6599916B2 (en) 2000-08-21 2003-07-29 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2001282875A1 (en) 2000-08-21 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
EP1334130A2 (en) * 2000-10-31 2003-08-13 Bayer Ag Regulation of human serotonin receptor precursor
PE20021019A1 (en) 2001-04-19 2002-11-13 Upjohn Co SUBSTITUTED AZABYCLE GROUPS
IL160651A0 (en) * 2001-08-31 2004-07-25 Agensys Inc Nucleic acid and correspondidng protein entitled 205pib5 and pharmaceutical compositions containing the same
US20030194720A1 (en) * 2001-09-12 2003-10-16 Roberds Steven L. Human ion channels
US7229779B2 (en) 2001-09-18 2007-06-12 Abbott Laboratories Variant human α7 acetylcholine receptor subunit, and methods of production and use thereof
US20060126682A1 (en) * 2001-10-08 2006-06-15 Geola Technologies Ltd. Pulsed multiple colour laser system
WO2003095976A2 (en) * 2002-05-09 2003-11-20 Memory Pharmaceuticals Corporation Qm-7 and qt-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells
AU2003253686A1 (en) * 2002-08-01 2004-02-23 Pharmacia & Upjohn Company Llc 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
US20040151729A1 (en) * 2002-10-28 2004-08-05 George Michalopoulos Novel long-term three-dimensional culture system
WO2004074245A2 (en) * 2003-02-14 2004-09-02 Memory Pharmaceuticals Corporation Monkey alpha-7 nicotinic acetylcholine receptor and methods of use thereof
US7576878B2 (en) * 2003-04-03 2009-08-18 Hewlett-Packard Development Company, L.P. Enhanced management of raster image processing resources
WO2005030145A2 (en) * 2003-09-24 2005-04-07 Targacept, Inc. Composition and pharmacology of novel alpha-6-containing nicotinic acetylcholine receptors
US20070249011A1 (en) * 2004-03-04 2007-10-25 Riken Method for Screening Fungus-Specific Antimicrobial Agent and Kit Therefor
EP1684324B1 (en) * 2005-01-20 2011-01-19 LG Electronics Inc. Plasma display panel
US20060269995A1 (en) * 2005-02-23 2006-11-30 Nailah Orr Novel assays utilizing nicotinic acetylcholine receptor subunits
US7879913B2 (en) * 2005-06-28 2011-02-01 Catholic Healthcare West Iptakalim hydrochloride for decreasing nicotine use
US20190275171A1 (en) * 2016-09-23 2019-09-12 Ionis Pharmaceuticals, Inc. Gene therapy and targeted delivery of conjugated compounds
CN111741760A (en) * 2017-11-27 2020-10-02 科达生物治疗医药有限公司 Compositions and methods for neurological disorders

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CA1341554C (en) 1988-03-18 2007-10-09 The Salk Institute For Biological Studies Neuronal nicotinic acetylcholine receptor compositions and assay
US5449606A (en) * 1988-03-18 1995-09-12 The Salk Institute For Biological Studies DNA encoding neuronal nicotinic acetylcholine receptor compositions containing the beta 4 subunit
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
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JP3102877B2 (en) * 1989-03-14 2000-10-23 ザ・ソーク・インスティチュート・フォー・バイオロジカル・スタディーズ Neuronal acetylcholine nicotinic acid receptor composition comprising beta 4 subunit
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WO1995013299A1 (en) 1993-11-08 1995-05-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Also Published As

Publication number Publication date
EP0688361A1 (en) 1995-12-27
WO1994020617A3 (en) 1994-10-27
JP2004194667A (en) 2004-07-15
US5910582A (en) 1999-06-08
DE69434067T2 (en) 2006-03-02
JPH08507441A (en) 1996-08-13
GB9503688D0 (en) 1995-04-12
CA2155330C (en) 2002-01-29
EP1508614A1 (en) 2005-02-23
AU6517394A (en) 1994-09-26
WO1994020617A2 (en) 1994-09-15
US6022704A (en) 2000-02-08
EP0688361B1 (en) 2004-10-13
US6303753B1 (en) 2001-10-16
DE69434067D1 (en) 2004-11-18
GB2286397C (en) 1997-09-10
GB2286397A (en) 1995-08-16
US5837489A (en) 1998-11-17
AU694424B2 (en) 1998-07-23
ES2229216T3 (en) 2005-04-16
GB2286397B (en) 1997-09-10
US6664375B2 (en) 2003-12-16
US20020111463A1 (en) 2002-08-15
JP3628691B2 (en) 2005-03-16
ATE279516T1 (en) 2004-10-15

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