CA2154590A1 - Phase shift colloids as ultrasound contrast agents - Google Patents

Phase shift colloids as ultrasound contrast agents

Info

Publication number
CA2154590A1
CA2154590A1 CA002154590A CA2154590A CA2154590A1 CA 2154590 A1 CA2154590 A1 CA 2154590A1 CA 002154590 A CA002154590 A CA 002154590A CA 2154590 A CA2154590 A CA 2154590A CA 2154590 A1 CA2154590 A1 CA 2154590A1
Authority
CA
Canada
Prior art keywords
liquid
dispersed
animal
contrast agents
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002154590A
Other languages
French (fr)
Other versions
CA2154590C (en
Inventor
Steven C. Quay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/008,172 external-priority patent/US5558855A/en
Application filed by Individual filed Critical Individual
Publication of CA2154590A1 publication Critical patent/CA2154590A1/en
Application granted granted Critical
Publication of CA2154590C publication Critical patent/CA2154590C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Abstract

Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the temperature of the animal to be imaged and which undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to the animal. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents.
Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.
CA002154590A 1993-01-25 1994-01-19 Phase shift colloids as ultrasound contrast agents Expired - Fee Related CA2154590C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/008,172 1993-01-25
US08/008,172 US5558855A (en) 1993-01-25 1993-01-25 Phase shift colloids as ultrasound contrast agents
US08/148,284 US5595723A (en) 1993-01-25 1993-11-08 Method for preparing storage stable colloids
US08/148,284 1993-11-08
PCT/US1994/000422 WO1994016739A1 (en) 1993-01-25 1994-01-19 Phase shift colloids as ultrasound contrast agents

Publications (2)

Publication Number Publication Date
CA2154590A1 true CA2154590A1 (en) 1994-08-04
CA2154590C CA2154590C (en) 2001-06-12

Family

ID=26677890

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002154590A Expired - Fee Related CA2154590C (en) 1993-01-25 1994-01-19 Phase shift colloids as ultrasound contrast agents

Country Status (18)

Country Link
US (3) US5558853A (en)
EP (1) EP0680341B1 (en)
JP (1) JP3621413B2 (en)
CN (1) CN1068230C (en)
AT (1) ATE200985T1 (en)
BR (1) BR9405667A (en)
CA (1) CA2154590C (en)
CZ (1) CZ191695A3 (en)
DE (1) DE69427185T2 (en)
ES (1) ES2158892T3 (en)
FI (1) FI953546A (en)
HU (1) HUT72323A (en)
NO (1) NO952819L (en)
NZ (1) NZ262237A (en)
PL (1) PL176116B1 (en)
SG (1) SG52198A1 (en)
SK (1) SK281535B6 (en)
WO (1) WO1994016739A1 (en)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN113640405A (en) * 2021-07-13 2021-11-12 南方电网科学研究院有限责任公司 Fault detection method for electrical equipment

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