CA2151742A1 - Compositions for Oral Delivery of Active Agents - Google Patents
Compositions for Oral Delivery of Active AgentsInfo
- Publication number
- CA2151742A1 CA2151742A1 CA2151742A CA2151742A CA2151742A1 CA 2151742 A1 CA2151742 A1 CA 2151742A1 CA 2151742 A CA2151742 A CA 2151742A CA 2151742 A CA2151742 A CA 2151742A CA 2151742 A1 CA2151742 A1 CA 2151742A1
- Authority
- CA
- Canada
- Prior art keywords
- compositions
- carrier
- active agent
- active agents
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6933—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Abstract
Compositions and methods for the oral administration of drugs and other active agents are provided. The compositions comprise an active agent carrier particle attached to a binding moiety which binds specifically to a target molecule present on the surface of a mammalian enterocyte. The binding moiety binds to the target molecule with a binding affinity or avidity sufficient to initiate endocytosis or phagocytosis of particulate active agent carrier so that the carrier will be absorbed by the enterocyte. The active agent will then be released from the carrier to the host's systemic circulation. In this way, degradation of degradation-sensitive drugs, such as polypeptides, in the intestines can be avoided while absorption of proteins and polypeptides from the intestinal tract is increased.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2048193A | 1993-02-22 | 1993-02-22 | |
US08/020,481 | 1993-02-22 | ||
PCT/US1994/001756 WO1994018955A1 (en) | 1993-02-22 | 1994-02-22 | Compositions for oral delivery of active agents |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2151742A1 true CA2151742A1 (en) | 1994-09-01 |
CA2151742C CA2151742C (en) | 1999-05-25 |
Family
ID=21798853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002151742A Expired - Fee Related CA2151742C (en) | 1993-02-22 | 1994-02-22 | Compositions for oral delivery of active agents |
Country Status (9)
Country | Link |
---|---|
US (2) | US5620708A (en) |
EP (1) | EP0684814B1 (en) |
JP (1) | JPH08507070A (en) |
AT (1) | ATE167396T1 (en) |
AU (1) | AU6268894A (en) |
CA (1) | CA2151742C (en) |
DE (1) | DE69411154T2 (en) |
MX (1) | MX9401351A (en) |
WO (1) | WO1994018955A1 (en) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996013250A1 (en) * | 1994-10-27 | 1996-05-09 | Amgem Inc. | Compositions for increased bioavailability of orally delivered therapeutic agents |
ATE252894T1 (en) * | 1995-01-05 | 2003-11-15 | Univ Michigan | SURFACE-MODIFIED NANOPARTICLES AND METHODS FOR THEIR PRODUCTION AND USE |
US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
SI9720025A (en) * | 1996-03-29 | 1999-08-31 | Emishphere Technologies, Inc. | Compounds and compositions for delivering active agents |
JP2000509270A (en) * | 1996-04-19 | 2000-07-25 | ヘンリー エム.ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン | Histidine-tagged intimin and method of using intimin as an antigen carrier to stimulate an immune response and to have targeting ability |
US6143037A (en) * | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
US6361938B1 (en) * | 1996-11-08 | 2002-03-26 | Elan Corporation, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
JP4203159B2 (en) * | 1997-12-09 | 2008-12-24 | 株式会社林原生物化学研究所 | Nerve function regulator |
US6355270B1 (en) * | 1999-01-11 | 2002-03-12 | The Regents Of The University Of California | Particles for oral delivery of peptides and proteins |
AU5721900A (en) * | 1999-03-08 | 2000-09-28 | Lockheed Martin Corporation | Single-pass interferometric synthetic aperture radar |
US8119101B2 (en) | 1999-05-10 | 2012-02-21 | The Ohio State University | Anti-CD74 immunoconjugates and methods of use |
US7829064B2 (en) * | 1999-05-10 | 2010-11-09 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods |
US8383081B2 (en) | 1999-05-10 | 2013-02-26 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods of use |
AU2044001A (en) * | 1999-11-19 | 2001-05-30 | Board Of Trustees Of The Leland Stanford Junior University | Targeted bifunctional molecules and therapies based thereon |
US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US6537968B1 (en) * | 2000-07-24 | 2003-03-25 | Alphamed Pharmaceuticals Corp | Treatment of lupus erythematosus |
US20040126900A1 (en) * | 2001-04-13 | 2004-07-01 | Barry Stephen E | High affinity peptide- containing nanoparticles |
CN101837120A (en) * | 2001-06-01 | 2010-09-22 | 诺瓦提斯公司 | Method for orally administering parathyroid hormone (PTH) |
JP2005511761A (en) * | 2001-07-10 | 2005-04-28 | ノース・キャロライナ・ステイト・ユニヴァーシティ | Nanoparticle delivery vehicle |
US9770517B2 (en) | 2002-03-01 | 2017-09-26 | Immunomedics, Inc. | Anti-Trop-2 antibody-drug conjugates and uses thereof |
US20050054557A1 (en) * | 2002-05-09 | 2005-03-10 | Goldberg Michael M. | Compositions for delivering parathyroid hormone and calcitonin |
US20050129769A1 (en) * | 2002-06-03 | 2005-06-16 | Barry Stephen E. | Polymeric articles for carrying therapeutic agents |
CA2487720A1 (en) * | 2002-06-03 | 2003-12-11 | Alnis Biosciences, Inc. | Therapeutic agent-containing polymeric nanoarticles |
PT1530482E (en) | 2002-07-18 | 2014-01-15 | Helix Biopharma Corp | Use of urease for inhibiting cancer cell growth |
WO2004035537A2 (en) | 2002-10-16 | 2004-04-29 | Euro-Celtique S.A. | Antibodies that bind cell-associated ca 125/o772p and methods of use thereof |
CA2505325C (en) | 2002-11-08 | 2014-02-25 | Ablynx N.V. | Stabilized single domain antibodies |
EP1558650A2 (en) | 2002-11-08 | 2005-08-03 | Ablynx N.V. | Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders |
US8420086B2 (en) | 2002-12-13 | 2013-04-16 | Immunomedics, Inc. | Camptothecin conjugates of anti-CD22 antibodies for treatment of B cell diseases |
EP1631259A4 (en) * | 2002-12-18 | 2006-08-02 | Hough Ear Inst | Otologic nanotechnology |
EP1587524A4 (en) * | 2003-01-09 | 2006-07-26 | Arizeke Pharmaceuticals Inc | Compositions and methods for targeted biological delivery of molecular carriers |
ES2542330T3 (en) | 2003-01-10 | 2015-08-04 | Ablynx N.V. | Therapeutic polypeptides, homologs thereof, fragments thereof and their use in modulating platelet-mediated aggregation |
WO2004069169A2 (en) * | 2003-01-31 | 2004-08-19 | Scimed Life Systems, Inc. | Localized drug delivery using drug-loaded nanocapsules and implantable device coated with the same |
DK1687338T3 (en) | 2003-11-07 | 2011-02-07 | Ablynx Nv | Camelidae single-domain antibodies VHH targeting epidermal growth factor receptor and uses thereof |
US9550838B2 (en) | 2004-02-13 | 2017-01-24 | Ibc Pharmaceuticals, Inc. | Dock-and-lock (DNL) complexes for therapeutic and diagnostic use |
US20110171126A1 (en) * | 2010-01-11 | 2011-07-14 | Center For Molecular Medicine And Immunology | Enhanced Cytotoxicity of Anti-CD74 and Anti-HLA-DR Antibodies with Interferon-Gamma |
US8883160B2 (en) * | 2004-02-13 | 2014-11-11 | Ibc Pharmaceuticals, Inc. | Dock-and-lock (DNL) complexes for therapeutic and diagnostic use |
PT1735349E (en) | 2004-04-15 | 2010-12-14 | Athera Biotechnologies Ab | Method of assessing the risk of ischemic cardiovascular disease using phosphorylcholine conjugates |
US20070265187A1 (en) * | 2004-04-29 | 2007-11-15 | Slobodan Vukicevic | Oral Formulations Comprising Bone Morphogenetic Proteins For Treating Metabolic Bone Diseases |
US7906140B2 (en) * | 2004-06-17 | 2011-03-15 | Virun, Inc. | Compositions for mucosal delivery of agents |
US20060047025A1 (en) * | 2004-06-29 | 2006-03-02 | Matthew Piazza | Viscous materials and method for producing |
US7282194B2 (en) * | 2004-10-05 | 2007-10-16 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
US9707302B2 (en) | 2013-07-23 | 2017-07-18 | Immunomedics, Inc. | Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer |
US10058621B2 (en) | 2015-06-25 | 2018-08-28 | Immunomedics, Inc. | Combination therapy with anti-HLA-DR antibodies and kinase inhibitors in hematopoietic cancers |
JP5214252B2 (en) | 2005-03-03 | 2013-06-19 | イミューノメディクス、インコーポレイテッド | Humanized L243 antibody |
WO2006099175A2 (en) * | 2005-03-11 | 2006-09-21 | Euro-Celtique S.A. | Compositions comprising an anti-ca125 antibody and a cytotoxic compound and their use for the treatment of cancer |
US8475794B2 (en) | 2005-04-06 | 2013-07-02 | Ibc Pharmaceuticals, Inc. | Combination therapy with anti-CD74 antibodies provides enhanced toxicity to malignancies, Autoimmune disease and other diseases |
US8349332B2 (en) | 2005-04-06 | 2013-01-08 | Ibc Pharmaceuticals, Inc. | Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases |
SG184709A1 (en) | 2005-05-18 | 2012-10-30 | Ablynx Nv | Improved nanobodies™ against tumor necrosis factor-alpha |
CA2960105A1 (en) | 2005-05-20 | 2006-11-23 | Ablynx Nv | Single domain vhh antibodies against von willebrand factor |
EP2674440B1 (en) | 2005-12-16 | 2019-07-03 | IBC Pharmaceuticals, Inc. | Multivalent immunoglobulin-based bioactive assemblies |
US8124598B2 (en) | 2006-09-14 | 2012-02-28 | Sharon Sageman | 7-keto DHEA for psychiatric use |
PT2118123E (en) | 2007-01-31 | 2016-02-10 | Harvard College | Stabilized p53 peptides and uses thereof |
EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
US20100160274A1 (en) * | 2007-09-07 | 2010-06-24 | Sharon Sageman | 7-KETO DHEA for Psychiatric Use |
US8491890B2 (en) | 2008-07-09 | 2013-07-23 | Board Of Regents Of The University Of Nebraska | Methods and compositions for inhibiting diseases of the central nervous system |
EA022699B1 (en) | 2009-05-27 | 2016-02-29 | Селекта Байосайенсиз, Инк. | Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents |
CN107029223A (en) | 2010-05-26 | 2017-08-11 | 西莱克塔生物科技公司 | Synthesize nano-carrier combined vaccine |
CA2807685C (en) | 2010-08-13 | 2020-10-06 | Aileron Therapeutics, Inc. | P53 derived peptidomimetic macrocycle |
KR20140050698A (en) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses |
JP6277126B2 (en) | 2011-08-09 | 2018-02-07 | アセラ・バイオテクノロジーズ・アーベー | Antibodies that bind to phosphorylcholine (PC) and / or PC conjugates |
CN104039832B (en) | 2011-08-09 | 2021-02-12 | 阿瑟拉生物技术公司 | Novel antibodies against phosphorylcholine |
TWI643868B (en) | 2011-10-18 | 2018-12-11 | 艾利倫治療公司 | Peptidomimetic macrocycles |
US9757458B2 (en) | 2011-12-05 | 2017-09-12 | Immunomedics, Inc. | Crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in hematopoietic cancer cells |
EP2788020A4 (en) | 2011-12-05 | 2015-04-29 | Immunomedics Inc | Therapeutic use of anti-cd22 antibodies for inducing trogocytosis |
US8987414B2 (en) | 2012-02-15 | 2015-03-24 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
MX362492B (en) | 2012-02-15 | 2019-01-21 | Aileron Therapeutics Inc | Peptidomimetic macrocycles. |
EP2914256B1 (en) | 2012-11-01 | 2019-07-31 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
US9492566B2 (en) | 2012-12-13 | 2016-11-15 | Immunomedics, Inc. | Antibody-drug conjugates and uses thereof |
US10413539B2 (en) | 2012-12-13 | 2019-09-17 | Immunomedics, Inc. | Therapy for metastatic urothelial cancer with the antibody-drug conjugate, sacituzumab govitecan (IMMU-132) |
US9931417B2 (en) | 2012-12-13 | 2018-04-03 | Immunomedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
KR102356017B1 (en) | 2012-12-13 | 2022-01-27 | 이뮤노메딕스, 인코오포레이티드 | Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity |
US10137196B2 (en) | 2012-12-13 | 2018-11-27 | Immunomedics, Inc. | Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity |
US10744129B2 (en) | 2012-12-13 | 2020-08-18 | Immunomedics, Inc. | Therapy of small-cell lung cancer (SCLC) with a topoisomerase-I inhibiting antibody-drug conjugate (ADC) targeting Trop-2 |
US10206918B2 (en) | 2012-12-13 | 2019-02-19 | Immunomedics, Inc. | Efficacy of anti-HLA-DR antiboddy drug conjugate IMMU-140 (hL243-CL2A-SN-38) in HLA-DR positive cancers |
US9107960B2 (en) | 2012-12-13 | 2015-08-18 | Immunimedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
US11253606B2 (en) | 2013-07-23 | 2022-02-22 | Immunomedics, Inc. | Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, Bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer |
EP2988130A1 (en) * | 2014-08-20 | 2016-02-24 | Eppendorf Ag | Method for coating a solid support |
SG10201902594QA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
BR112017015582A2 (en) | 2015-01-23 | 2018-03-13 | Helix Biopharma Corp | antibody-urease conjugates for therapeutic purposes |
AU2016235424A1 (en) | 2015-03-20 | 2017-10-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
CA2981543A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
US10195175B2 (en) | 2015-06-25 | 2019-02-05 | Immunomedics, Inc. | Synergistic effect of anti-Trop-2 antibody-drug conjugate in combination therapy for triple-negative breast cancer when used with microtubule inhibitors or PARP inhibitors |
CN108601841A (en) | 2016-02-10 | 2018-09-28 | 免疫医疗公司 | The combination of ABCG2 inhibitor and SACITUZUMAB GOVITECAN (IMMU-132) overcome the resistance to SN-38 in the cancer for expressing TROP-2 |
JP7379795B2 (en) | 2016-04-27 | 2023-11-15 | イミューノメディクス、インコーポレイテッド | Efficacy of anti-Trop-2-SN-38 antibody-drug conjugate for treating tumors relapsed/resistant to checkpoint inhibitors. |
US11491114B2 (en) | 2016-10-12 | 2022-11-08 | Curioralrx, Llc | Formulations for enteric delivery of therapeutic agents |
EP3600283A4 (en) | 2017-03-27 | 2020-12-16 | Immunomedics, Inc. | Treatment of trop-2 expressing triple negative breast cancer with sacituzumab govitecan and a rad51 inhibitor |
US10799597B2 (en) | 2017-04-03 | 2020-10-13 | Immunomedics, Inc. | Subcutaneous administration of antibody-drug conjugates for cancer therapy |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3995631A (en) * | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
US4034756A (en) * | 1971-01-13 | 1977-07-12 | Alza Corporation | Osmotically driven fluid dispenser |
US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US4111202A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
US4320759A (en) * | 1980-04-28 | 1982-03-23 | Alza Corporation | Dispenser with diffuser |
US4449983A (en) * | 1982-03-22 | 1984-05-22 | Alza Corporation | Simultaneous delivery of two drugs from unit delivery device |
US4925678A (en) * | 1987-04-01 | 1990-05-15 | Ranney David F | Endothelial envelopment drug carriers |
JPS63264069A (en) * | 1987-04-22 | 1988-10-31 | 出光興産株式会社 | Cell adhesive material |
GB8826116D0 (en) * | 1988-11-08 | 1988-12-14 | Danbiosyst Ltd | Adhesive drug delivery composition |
US5320824A (en) * | 1989-10-12 | 1994-06-14 | Mallinckrodt Medical, Inc. | Radionuclide labelled particles useful for radiation synovectomy |
US5614652A (en) * | 1991-01-07 | 1997-03-25 | Syngenix Limited | Particulates |
JPH05506040A (en) * | 1991-02-14 | 1993-09-02 | バクスター、インターナショナル、インコーポレイテッド | Interaction between bioadhesive liposomes and target sites |
IE921050A1 (en) * | 1991-04-02 | 1992-10-07 | Biotech Australia Pty Ltd | Oral delivery systems for microparticles |
-
1994
- 1994-02-22 EP EP94910129A patent/EP0684814B1/en not_active Expired - Lifetime
- 1994-02-22 AT AT94910129T patent/ATE167396T1/en active
- 1994-02-22 DE DE69411154T patent/DE69411154T2/en not_active Expired - Fee Related
- 1994-02-22 AU AU62688/94A patent/AU6268894A/en not_active Abandoned
- 1994-02-22 WO PCT/US1994/001756 patent/WO1994018955A1/en active IP Right Grant
- 1994-02-22 JP JP6519156A patent/JPH08507070A/en not_active Ceased
- 1994-02-22 CA CA002151742A patent/CA2151742C/en not_active Expired - Fee Related
- 1994-02-22 MX MX9401351A patent/MX9401351A/en unknown
-
1995
- 1995-02-01 US US08/382,476 patent/US5620708A/en not_active Expired - Lifetime
- 1995-03-06 US US08/409,613 patent/US5702727A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH08507070A (en) | 1996-07-30 |
DE69411154D1 (en) | 1998-07-23 |
ATE167396T1 (en) | 1998-07-15 |
DE69411154T2 (en) | 1998-10-22 |
MX9401351A (en) | 1994-08-31 |
EP0684814B1 (en) | 1998-06-17 |
WO1994018955A1 (en) | 1994-09-01 |
CA2151742C (en) | 1999-05-25 |
EP0684814A1 (en) | 1995-12-06 |
US5620708A (en) | 1997-04-15 |
US5702727A (en) | 1997-12-30 |
AU6268894A (en) | 1994-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |