CA2148823A1 - Sustained Release Microsphere Preparation Containing Antipsychotic Drug and Production Process Thereof - Google Patents
Sustained Release Microsphere Preparation Containing Antipsychotic Drug and Production Process ThereofInfo
- Publication number
- CA2148823A1 CA2148823A1 CA2148823A CA2148823A CA2148823A1 CA 2148823 A1 CA2148823 A1 CA 2148823A1 CA 2148823 A CA2148823 A CA 2148823A CA 2148823 A CA2148823 A CA 2148823A CA 2148823 A1 CA2148823 A1 CA 2148823A1
- Authority
- CA
- Canada
- Prior art keywords
- sustained release
- antipsychotic drug
- microsphere preparation
- release microsphere
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Abstract
A sustained release microsphere preparation which is produced by including a hydrophobic antipsychotic drug such as bromperidol, haloperidol or the like into a base composed of a high molecular weight polymer having in vivo histocompatibility such as polylactic acid, poly(lactic-co-glycolic)acid or the like, and a process for the production thereof.
When a long-term administration is required, desired pharmacological effects can be obtained by one injection per 1 to 8 weeks, in stead of daily administration. As the result, considerable improvement in compliance at the time of maintenance therapy can be expected. Also, since a high molecular weight polymer having in vivo histocompatibility is used, surgical operations such as embedding and the like are not required at all, and subcutaneous and intramuscular administrations can be made easily absolutely in the same manner as the case of conventional suspension injections so that recovery of the material is not required. In addition, resistance and pain at the time of administration are small.
When a long-term administration is required, desired pharmacological effects can be obtained by one injection per 1 to 8 weeks, in stead of daily administration. As the result, considerable improvement in compliance at the time of maintenance therapy can be expected. Also, since a high molecular weight polymer having in vivo histocompatibility is used, surgical operations such as embedding and the like are not required at all, and subcutaneous and intramuscular administrations can be made easily absolutely in the same manner as the case of conventional suspension injections so that recovery of the material is not required. In addition, resistance and pain at the time of administration are small.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33244192 | 1992-11-17 | ||
JP4-332441 | 1992-11-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2148823A1 true CA2148823A1 (en) | 1994-05-26 |
CA2148823C CA2148823C (en) | 1999-03-09 |
Family
ID=18255017
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002148823A Expired - Fee Related CA2148823C (en) | 1992-11-17 | 1993-11-15 | Sustained release microsphere preparation containing antipsychotic drug and production process thereof |
Country Status (11)
Country | Link |
---|---|
US (2) | US5656299A (en) |
EP (1) | EP0669128B1 (en) |
KR (1) | KR100333115B1 (en) |
AT (1) | ATE188375T1 (en) |
CA (1) | CA2148823C (en) |
DE (2) | DE69327542T2 (en) |
DK (1) | DK0669128T3 (en) |
ES (1) | ES2077547T3 (en) |
GR (2) | GR960300020T1 (en) |
PT (1) | PT669128E (en) |
WO (1) | WO1994010982A1 (en) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440457B1 (en) * | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
EP2283821A1 (en) * | 1993-11-19 | 2011-02-16 | Alkermes, Inc. | Preparation of biodegradable microparticles containing a biologically active agent |
NZ276088A (en) * | 1993-11-19 | 1999-07-29 | Janssen Pharmaceutica Nv | [(1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-6,7,8,9-tetrahydro-4h- pyrido[1,2-a]-pyrimidin-4-one derivatives (ie risperidone) |
EP0733368A1 (en) * | 1995-03-24 | 1996-09-25 | Eli Lilly And Company | Granule fomulation for olanzapine |
FR2748205A1 (en) | 1996-05-06 | 1997-11-07 | Debio Rech Pharma Sa | PHARMACEUTICAL COMPOSITIONS FOR THE CONTROLLED RELEASE OF INSOLUBLE ACTIVE SUBSTANCES |
US5792477A (en) | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
DK1210942T3 (en) * | 1996-05-07 | 2007-07-23 | Alkermes Inc | Microparticles |
EP1616563A3 (en) * | 1996-05-24 | 2006-01-25 | Angiotech Pharmaceuticals, Inc. | Perivascular administration of anti-angiogenic factors for treating or preventing vascular diseases |
ATE272394T1 (en) * | 1996-10-31 | 2004-08-15 | Takeda Chemical Industries Ltd | DELAYED RELEASE PREPARATION |
IL123716A (en) * | 1997-03-27 | 2001-03-19 | Akzo Nobel Nv | Therapeutic combinations of mirtazapine and an antipsychotic agent |
GB9718986D0 (en) * | 1997-09-09 | 1997-11-12 | Danbiosyst Uk | Controlled release microsphere delivery system |
US6854841B1 (en) * | 1998-04-17 | 2005-02-15 | Elesys, Inc. | Point-of-incidence ink-curing mechanisms for radial printing |
US6224794B1 (en) | 1998-05-06 | 2001-05-01 | Angiotech Pharmaceuticals, Inc. | Methods for microsphere production |
GB9817078D0 (en) * | 1998-08-05 | 1998-10-07 | Habib Nagy A | Device for liver surgery |
DK1119359T3 (en) * | 1998-09-30 | 2004-08-16 | Lilly Co Eli | 2-methyl-thieno-benzodiazepine formulation |
US20080213378A1 (en) * | 1998-10-01 | 2008-09-04 | Elan Pharma International, Ltd. | Nanoparticulate statin formulations and novel statin combinations |
US20040013613A1 (en) * | 2001-05-18 | 2004-01-22 | Jain Rajeev A | Rapidly disintegrating solid oral dosage form |
US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
US8293277B2 (en) * | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
EP1117384A1 (en) * | 1998-10-01 | 2001-07-25 | Elan Pharma International Limited | Controlled release nanoparticulate compositions |
US6428814B1 (en) * | 1999-10-08 | 2002-08-06 | Elan Pharma International Ltd. | Bioadhesive nanoparticulate compositions having cationic surface stabilizers |
US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US6194006B1 (en) | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
EP1162956B8 (en) * | 1999-02-23 | 2005-08-10 | Angiotech International AG | Compositions and methods for improving integrity of compromised body passageways and cavities |
US20090104273A1 (en) * | 1999-06-22 | 2009-04-23 | Elan Pharma International Ltd. | Novel nifedipine compositions |
US6495166B1 (en) | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
US6705757B2 (en) | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
US6331317B1 (en) | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
US6599532B2 (en) * | 2000-01-13 | 2003-07-29 | Osmotica Corp. | Osmotic device containing alprazolam and an antipsychotic agent |
US20040156872A1 (en) * | 2000-05-18 | 2004-08-12 | Elan Pharma International Ltd. | Novel nimesulide compositions |
US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
US6824822B2 (en) * | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
US7198795B2 (en) | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
US6471995B1 (en) | 2000-09-27 | 2002-10-29 | Alkermes Controlled Therapeutics, Inc. Ii | Apparatus and method for preparing microparticles using liquid-liquid extraction |
US7666445B2 (en) * | 2000-10-20 | 2010-02-23 | The Trustees Of The University Of Pennsylvania | Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use |
AU3323902A (en) * | 2000-12-13 | 2002-06-24 | Merckle Gmbh | Microparticles with an improved release profile and method for the production thereof |
US20020114843A1 (en) * | 2000-12-27 | 2002-08-22 | Ramstack J. Michael | Preparation of microparticles having improved flowability |
EP1408876A4 (en) | 2001-06-22 | 2004-09-22 | Durect Corp | Zero-order prolonged release coaxial implants |
EP1411861B1 (en) | 2001-06-29 | 2012-04-04 | Medgraft Microtech, Inc. | Biodegradable injectable implants and related methods of manufacture and use |
US7615233B2 (en) | 2001-07-10 | 2009-11-10 | Canon Kabushiki Kaisha | Particulate construct comprising polyhydroxyalkanoate and method for producing it |
US20040101566A1 (en) * | 2002-02-04 | 2004-05-27 | Elan Pharma International Limited | Novel benzoyl peroxide compositions |
ATE464880T1 (en) | 2002-02-04 | 2010-05-15 | Elan Pharma Int Ltd | MEDICINAL NANOPARTICLES WITH LYSOZYME SURFACE STABILIZER |
US6699963B2 (en) * | 2002-03-18 | 2004-03-02 | The Procter & Gamble Company | Grinding process for plastic material and compositions therefrom |
IL164152A0 (en) * | 2002-03-26 | 2005-12-18 | Teva Pharma | Drug microparticles |
GB0216416D0 (en) * | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
US20040258757A1 (en) * | 2002-07-16 | 2004-12-23 | Elan Pharma International, Ltd. | Liquid dosage compositions of stable nanoparticulate active agents |
US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
CA2500065A1 (en) * | 2002-09-30 | 2004-04-15 | Acusphere, Inc. | Sustained release porous microparticles for inhalation |
US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
US6962006B2 (en) | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
CA2516339A1 (en) * | 2003-02-19 | 2004-09-02 | Takeda Pharmaceutical Company Limited | Dispersing agent for sustained-release preparation |
JP2004331750A (en) | 2003-05-02 | 2004-11-25 | Canon Inc | Magnetic structure comprising polyhydroxyalkanoate and method for producing the same and use thereof |
NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
US6987111B2 (en) * | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
CA2553254C (en) * | 2004-01-12 | 2013-12-17 | The Trustees Of The University Of Pennsylvania | Long-term delivery formulations and methods of use thereof |
WO2007011955A2 (en) * | 2005-07-18 | 2007-01-25 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
US8329203B2 (en) | 2004-01-12 | 2012-12-11 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
MXPA06011924A (en) | 2004-04-15 | 2007-06-11 | Alkermes Inc | Polymer-based sustained release device. |
WO2005110369A2 (en) * | 2004-04-30 | 2005-11-24 | American Pharmaceutical Partners, Inc. | Sustained-release microspheres and methods of making and using same |
ITMI20042232A1 (en) * | 2004-11-19 | 2005-02-19 | Unihart Corp | PHARMACEUTICAL COMPOSITION CONTAINING CLOZAPINE |
PT1838716E (en) | 2005-01-05 | 2011-07-15 | Lilly Co Eli | Olanzapine pamoate dihydrate |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
US7669732B2 (en) * | 2005-10-25 | 2010-03-02 | Imi Cornelius Inc. | Cup lid dispenser |
PL116330U1 (en) | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
US7811604B1 (en) * | 2005-11-14 | 2010-10-12 | Barr Laboratories, Inc. | Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same |
ES2422864T3 (en) | 2006-08-09 | 2013-09-16 | Intarcia Therapeutics, Inc | Osmotic release systems and piston units |
US7538652B2 (en) * | 2006-08-29 | 2009-05-26 | International Business Machines Corporation | Electrical component tuned by conductive layer deletion |
CN101541316A (en) * | 2006-10-05 | 2009-09-23 | 万能药生物有限公司 | Injectable depot compositions and process of preparation of such compositions |
JP2010522196A (en) * | 2007-03-22 | 2010-07-01 | アルカームズ,インコーポレイテッド | Coacervation process |
RU2440097C2 (en) | 2007-04-23 | 2012-01-20 | Интарсия Терапьютикс, Инк. | Method of treating insulin-independent diabetes and obesity, osmotic delivery system and method for making it |
MX337286B (en) | 2007-05-25 | 2016-02-22 | Indivior Uk Ltd | Sustained delivery formulations of risperidone compounds. |
WO2008157540A1 (en) * | 2007-06-20 | 2008-12-24 | Alkermes, Inc. | Quench liquids and washing systems for production of microparticles |
KR101892745B1 (en) | 2007-06-25 | 2018-08-28 | 오쓰까 세이야꾸 가부시키가이샤 | Microspheres having core/shell structure |
US9161943B2 (en) * | 2007-12-31 | 2015-10-20 | Industrial Technology Research Institute | Sustained release composition and manufacturing method thereof |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
WO2010144016A1 (en) | 2009-06-09 | 2010-12-16 | Neuronano Ab | Microelectrode and multiple microelectrodes comprising means for releasing drugs into the tissue |
EP3323423B1 (en) | 2009-09-28 | 2020-06-17 | Intarcia Therapeutics, Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
US8641900B2 (en) * | 2009-11-05 | 2014-02-04 | Taiwan Biotech Co., Ltd | Method and device for continuously preparing microspheres, and collection unit thereof |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
PL2701687T3 (en) * | 2011-04-25 | 2017-03-31 | Shandong Luye Pharmaceutical Co., Ltd. | Risperidone sustained release microsphere composition |
CN103301461B (en) * | 2012-03-08 | 2018-09-07 | 江苏豪森药业集团有限公司 | A kind of long acting injection and its preparation method and application |
EA033537B1 (en) | 2013-03-11 | 2019-10-31 | Durect Corp | Injectable controlled release composition comprising high viscosity liquid carrier |
US20140308352A1 (en) | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
KR101738127B1 (en) * | 2014-08-08 | 2017-05-22 | (주)비씨월드제약 | A method for producing drug-containing sustained release micro particle |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
EP3302354B1 (en) | 2015-06-03 | 2023-10-04 | i2o Therapeutics, Inc. | Implant placement systems |
WO2017200943A1 (en) | 2016-05-16 | 2017-11-23 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
KR20190104039A (en) | 2017-01-03 | 2019-09-05 | 인타르시아 세라퓨틱스 인코포레이티드 | Methods Including Continuous Administration of GLP-1 Receptor Agonists and Co-administration of Drugs |
JP7437074B2 (en) * | 2019-07-12 | 2024-02-22 | ジー2ジーバイオ インコーポレイテッド | Long-acting preparation containing rivastigmine and its manufacturing method |
CN111991397B (en) * | 2020-10-13 | 2021-09-10 | 深圳善康医疗健康产业有限公司 | Flupentixol melitracen microsphere and preparation method thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
JPS568318A (en) * | 1979-06-28 | 1981-01-28 | Janssen Pharmaceutica Nv | Non oral long acting composition of haloperidol and bromperidol derivative |
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
FR2534139B1 (en) * | 1982-10-07 | 1986-08-29 | Laruelle Claude | NOVEL GALENIC FORM OF SULPIRIDE, METHOD FOR PREPARING SAME, AND MEDICINAL PRODUCT COMPRISING THIS NEW FORM |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
JPS63122620A (en) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | Polylactic acid microsphere and production thereof |
IT1216570B (en) * | 1988-04-08 | 1990-03-08 | Vectorpharma Int | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION AND PROCEDURE FOR THEIR PREPARATION. |
-
1993
- 1993-11-15 WO PCT/JP1993/001673 patent/WO1994010982A1/en not_active Application Discontinuation
- 1993-11-15 DE DE69327542T patent/DE69327542T2/en not_active Revoked
- 1993-11-15 DK DK93924827T patent/DK0669128T3/en active
- 1993-11-15 AT AT93924827T patent/ATE188375T1/en not_active IP Right Cessation
- 1993-11-15 ES ES93924827T patent/ES2077547T3/en not_active Expired - Lifetime
- 1993-11-15 KR KR1019950701853A patent/KR100333115B1/en not_active IP Right Cessation
- 1993-11-15 PT PT93924827T patent/PT669128E/en unknown
- 1993-11-15 CA CA002148823A patent/CA2148823C/en not_active Expired - Fee Related
- 1993-11-15 DE DE0669128T patent/DE669128T1/en active Pending
- 1993-11-15 EP EP93924827A patent/EP0669128B1/en not_active Revoked
-
1995
- 1995-05-17 US US08/443,021 patent/US5656299A/en not_active Expired - Fee Related
-
1996
- 1996-03-31 GR GR960300020T patent/GR960300020T1/en unknown
-
1997
- 1997-03-07 US US08/812,544 patent/US5871778A/en not_active Expired - Fee Related
-
2000
- 2000-03-21 GR GR20000400702T patent/GR3033016T3/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69327542T2 (en) | 2000-07-06 |
DE669128T1 (en) | 1996-03-14 |
ES2077547T3 (en) | 2000-06-16 |
KR100333115B1 (en) | 2002-12-02 |
ES2077547T1 (en) | 1995-12-01 |
EP0669128A4 (en) | 1996-09-25 |
CA2148823C (en) | 1999-03-09 |
DE69327542D1 (en) | 2000-02-10 |
GR3033016T3 (en) | 2000-08-31 |
KR950703936A (en) | 1995-11-17 |
PT669128E (en) | 2000-06-30 |
ATE188375T1 (en) | 2000-01-15 |
EP0669128B1 (en) | 2000-01-05 |
GR960300020T1 (en) | 1996-03-31 |
US5871778A (en) | 1999-02-16 |
US5656299A (en) | 1997-08-12 |
EP0669128A1 (en) | 1995-08-30 |
DK0669128T3 (en) | 2000-06-19 |
WO1994010982A1 (en) | 1994-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2148823A1 (en) | Sustained Release Microsphere Preparation Containing Antipsychotic Drug and Production Process Thereof | |
WO1997013502A3 (en) | Prolonged release of gm-csf | |
NZ226514A (en) | Poly-d,l-lactide based biodegradable implant | |
AU4275597A (en) | Erythropoietin drug delivery system | |
CA2314151A1 (en) | Polyhydroxyalkanoate compositions having controlled degradation rates | |
MX9709699A (en) | Composition for sustained release of non-aggregated erythropoietin. | |
GR3015485T3 (en) | Sustained-release particulate preparation and process for preparing the same. | |
DE69930240D1 (en) | MATRIZES MADE OF POLYMER AND HYDROPHOBIC COMPOUNDS FOR USE IN THE DISPOSAL OF MEDICINAL PRODUCTS | |
EP0301856A3 (en) | Delivery system | |
GR3032056T3 (en) | Drug delivery system involving interaction between protein or polypeptide and hydrophobic biodegradable polymer. | |
EP0767634A4 (en) | Microcapsules for administration of neuroactive agents | |
HUT61196A (en) | Process for producing pharmaceutical composition which may be dropped in the eye | |
GEP20033078B (en) | Controlled-Release Compositions of Betahistine | |
DE3889933D1 (en) | Peroral drug preparation with delayed drug release. | |
WO2000074709A3 (en) | Modified biodegradable polyester microspheres for stabilizing and improving the release profile of drugs encapsulated within the microspheres | |
CA2234585A1 (en) | Prolonged release of gm-csf | |
Lim | Development of Local Drug Delivery System: Prolonged Sciatic Nerve Blockade From Biodegradable Microspheres |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |