CA2148670A1 - Vascular graft impregnated with a heparin-containing collagen sealant - Google Patents

Vascular graft impregnated with a heparin-containing collagen sealant

Info

Publication number
CA2148670A1
CA2148670A1 CA002148670A CA2148670A CA2148670A1 CA 2148670 A1 CA2148670 A1 CA 2148670A1 CA 002148670 A CA002148670 A CA 002148670A CA 2148670 A CA2148670 A CA 2148670A CA 2148670 A1 CA2148670 A1 CA 2148670A1
Authority
CA
Canada
Prior art keywords
heparin
vascular graft
collagen
containing collagen
dispersion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002148670A
Other languages
French (fr)
Other versions
CA2148670C (en
Inventor
Kevin Weadock
David J. Lentz
Jack Tant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maquet Cardiovascular LLC
Original Assignee
Kevin Weadock
David J. Lentz
Jack Tant
Meadox Medicals, Inc.
Meadox Technology, Inc.
Scimed Life Systems, Inc.
Boston Scientific Scimed, Inc.
Maquet Cardiovascular Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kevin Weadock, David J. Lentz, Jack Tant, Meadox Medicals, Inc., Meadox Technology, Inc., Scimed Life Systems, Inc., Boston Scientific Scimed, Inc., Maquet Cardiovascular Llc filed Critical Kevin Weadock
Publication of CA2148670A1 publication Critical patent/CA2148670A1/en
Application granted granted Critical
Publication of CA2148670C publication Critical patent/CA2148670C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic
    • Y10S623/921—Blood vessel

Abstract

A heparin-collagen dispersion is provided for impregnating a vascular prosthesis with heparin and collagen. The dispersion is prepared at an alkaline pH to allow the addition of heparin without causing the agglutination of collagen from the dispersion. The impregnation of collagen and heparin within the prosthesis effectively prevents blood loss and thrombus formation after implantation of the prosthesis.
CA002148670A 1994-08-12 1995-05-04 Vascular graft impregnated with a heparin-containing collagen sealant Expired - Fee Related CA2148670C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28979294A 1994-08-12 1994-08-12
US08/289,792 1994-08-12

Publications (2)

Publication Number Publication Date
CA2148670A1 true CA2148670A1 (en) 1996-02-13
CA2148670C CA2148670C (en) 2008-05-13

Family

ID=23113122

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002148670A Expired - Fee Related CA2148670C (en) 1994-08-12 1995-05-04 Vascular graft impregnated with a heparin-containing collagen sealant

Country Status (7)

Country Link
US (2) US5851230A (en)
EP (1) EP0698396B1 (en)
JP (1) JP3504389B2 (en)
AU (1) AU700584C (en)
CA (1) CA2148670C (en)
DE (1) DE69524501T2 (en)
FI (1) FI952217A (en)

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Also Published As

Publication number Publication date
EP0698396A1 (en) 1996-02-28
AU1772195A (en) 1996-02-22
DE69524501T2 (en) 2002-05-29
JP3504389B2 (en) 2004-03-08
DE69524501D1 (en) 2002-01-24
AU700584C (en) 2002-03-28
JPH0866469A (en) 1996-03-12
US5851230A (en) 1998-12-22
AU700584B2 (en) 1999-01-07
EP0698396B1 (en) 2001-12-12
US6162247A (en) 2000-12-19
FI952217A (en) 1996-02-13
CA2148670C (en) 2008-05-13
FI952217A0 (en) 1995-05-08

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