CA2142901A1 - Medication injection device - Google Patents
Medication injection deviceInfo
- Publication number
- CA2142901A1 CA2142901A1 CA002142901A CA2142901A CA2142901A1 CA 2142901 A1 CA2142901 A1 CA 2142901A1 CA 002142901 A CA002142901 A CA 002142901A CA 2142901 A CA2142901 A CA 2142901A CA 2142901 A1 CA2142901 A1 CA 2142901A1
- Authority
- CA
- Canada
- Prior art keywords
- syringe
- injection device
- needle
- barrel
- penis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
- A61F5/41—Devices for promoting penis erection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/16—Male reproductive, genital organs
- A61M2210/167—Penis
Abstract
This invention relates to an automatic injection device (10) which, upon activation by the user, automatically extends a sy-ringe (11) with needle (12), delivers medication through the needle (12), and retracts the needle (12) thus keeping the needle (12) hidden from view.
Description
2142gOl APPLICATION FOR PATENT
TITL~: MEDICATION lN~ lON DEVTCE
S~ rlCATION
BA~K~uN~ OF THE lNV~llON
l. Field of the Invention This invention relates to a medication injection device which, upon being activated by the user, delivers medication from a syringe with needle to the user with the needle being in a retracted, h i ~en position at all times exce~ when actual injection 0 GC~u~ D . More particularly, this device permits treatment of a~pL~iate cases of male erectile dyaru,.ction by ~ccurate plac - L and i--L-Gduction of subst~ncec into the erectile bodies (~G~.a cav~..osa) of the penis.
TITL~: MEDICATION lN~ lON DEVTCE
S~ rlCATION
BA~K~uN~ OF THE lNV~llON
l. Field of the Invention This invention relates to a medication injection device which, upon being activated by the user, delivers medication from a syringe with needle to the user with the needle being in a retracted, h i ~en position at all times exce~ when actual injection 0 GC~u~ D . More particularly, this device permits treatment of a~pL~iate cases of male erectile dyaru,.ction by ~ccurate plac - L and i--L-Gduction of subst~ncec into the erectile bodies (~G~.a cav~..osa) of the penis.
2. Descri~tion of the Related Art It is well known that many persons are apprehensive of receiving an injection from a hypodermic needle. This situation is worsened for those who must administer their own injections, such as diabetic patients and others who regularly require medication or who re~uire that medication be administered in private or in emergency situations, such as ~cute allergies to insect bites (anaphylaxis), hypoglycemic reactions, etc. This apprehension is ; particularly acute in the treatment of male erectile dysfunction with direct injection of medication into the penis.
3 ,~4z~ PCT/US93/07855 ~
While the invention is int~n~A to be used in con~unction with the administration of medicine of any physical form to various parts of the body and to various t;sCll~ depths, it is partic~lArly applicable for use in the treai - L of erectile dysf~ction.
Defined simply, erectile dy~f~ction o~urD when a male is unable to maintain adequate p~ni le rigidity n~c~cff~ry to initiate, sustain and ~ cessfully c~n -te the act of coitus. It denotes organic impotence.
This condition can be a psychologically devastating therapeutic problem. It has been estimated to effect 50% of all diabetic men and up to 9% of y~ullye~ men in apparent good health. Varying degrees of erectile dysfunction c~-~ce~ by age, drug use, arteriosclerosis, trauma, hr _ ? disorders and surgical ~Loce.1..es have also been observed.
Di~inich~ male erectile l~X~Ol'~e iS the limiting factor in 5~al relationch;rs. The fear of erectile failure has been La~oLLed as one of the primary reACQn~
for decreased libido in older males.
The penile erection - An i ~ _ of the ,.~, -1 male is a complex interaction of hormones, n~u ~L~ansmitters and blood v~cs~ls. An erection begins when paired penile arteries dilate in reCpo~ce to neuLu~ansmitters rel~Y; ng the smooth muscle walls of the arteries. An increased inC i~ blood flow e~ Lyes the ~h: h~r5 of the penis (~u-~ra cavernosa) where it is LL~ed. The tough and fibrous encasing tunica albuginea is stretched by tur-~ re and c~ _esses perforating veins which drain the blood filled ~hr h~r5 . Venous drainage is impeded and further penile rigidity ~n In organic impotent males, this vA~c1~lAr-erection ?chAnis~ is substantially impaired, not activated or not intact.
2 1 ~ 2 9 0 1 Self-injection of vasoactive pharmacotherapeutic agents directly into the penis for treatment of erectile ~y~fu~-ction is known. Intraca~e ,.~us p~a~line, phentolamine and prostagl An~ i n El frequently are used indivi ~ 1 ly or in synergistic mi~Lu~Ls to replace the absent n~u~LL~nsmitter mediated v~c~ r dilatation and ~lhC~quent physiologic erection. Nitric oxide or a natural neulo L.~nsmitter-ho- ?, vasoactive intestinal peptide, may be the fuLu,e vasoactive agents of choice.
While clinical ~-ccesc with intra c~v~ ..uus pharmacotherapy ~Y~e~C 75%, many patients do not initiate or Al~n~n self-injection therapy once it has been tried. The most common reason self-injection is not used is a universal phobia of illL,G~ cing a needle into one's penis. Other r~CQ~c include on older patient's ineptitude, manual tremors and loss of dexterity n~c~csAry to locate injection site; physical hAndicaps of blin~n~fifi, loss of limb and abdominal obesity; tra~ urLation inc~nv~,,ience; prolonged Gyringe needle-vial drawing t~hn iques; lack of .~.,Laneity during love ~kinq; objections from ~
partner; and lack of self-injection confi~n~e, plus the natural apprehensions that professional assistance is required to avoid hemorrhage or priapism.
Various types of syringes have been developed for injecting drugs into the penis or for self-administration of drugs into other parts of the body.
These devices, which have proved ineffective for various reasons, include the one shown in U.S. patent 4,150,669 to Latorre. A dual hypodermic needle syringe for injecting fluids into the penis is shown, which has two parallel, inte~.o. .ected barrels çonnected to needles exten~ing from the barrels. This device has the disadvantage that the syringe needles must be W O 94/04103 PC~r/US93/07855 ~
21~29l ~ y il---u3-~-e~ into the penis and manual depression of the plunger(s) is re~uired to inject the me~icinAl fluid from the syringe and ne~le into the penis.
Various forms of spri.. ~ e~!irpe~ syringe holders and actustors are known, such as the ones snown in U.S.
patents 3,941,130 (Tibbs), 4,261,358 (Vargas et al.) and 4,188,950 (Wardlaw). ~rJ_~., these devices do not utilize a ~ch~ni ! which allows for automatic insertion of the nee~l~, injection of the fluid, and retraction of the needle provided in a _ -ct, discrete device.
Thus, there exists the need for an automatic injection device which allows easy and accurate self-injection of medication. This need is partic~ rlyacute in the self-injection of medication into one's penis where there is the additi OnA 1 need of keeping the needle hi~Pn from view to eliminate nee~leCc anxiety.
SUMMARY OF THE lNv~llON
The invention relates to ~n automatic injection device, which upon activation by the user, automatically i,.~.Gllces a needle into an individual, injects the medication cont~i n~ in the syringe and then retracts the needle from the individual. While the present invention relates to injection into any body part and to any depth, i.e., intradermal, subcutaneous, or intr~ Cc~l A r, the preferred : ho~i -nt relates to direct, automatic injection of medication into the penis for treatment of male erectile dy~fullction.
The automatic injection device has a housing with a 51 i~;nq cam - `~n;~ which is powered by an exte~e~
spring and activated by a trigger - Anism. The housing has an integral barrel section located 21~2~01 WO 94/04tO3 ^ PCT/US93/07855 ~e~lJr~ r to the path of the slidin~ cam me~h~nism which contains a syringe with needle. Upon activation, one surface of the sl;~;ng cam me~h~nism contacts the syringe, pllchjng the syringe from its initial position to an ex~en~^~ position such that the needle is inserted into the individual. A secQn~ surface of the sli~ing cam ~-hAni~ p~cheR the syringe plunger for administering fluid cont~inP~ in the syringe into the individual. The needle is then automatically retracted within the barrel such that the needle remains h i dd from sight.
The present invention provides an automatic injection device which will inject medication with an llnQ~n needle, thus overcoming an individual's fear of neèdles while providing conv~n;~ce and the ~o~e-dosage.
The present invention also provides a useful device which makes self-injection of medication into the penis for cases of erectile dy~ru~lction a relatively simply procedure. The device allows easy and correct placement with a h i ~n needle that automatically penetrates, injects medication and retracts.
The device is compact, discrete, and easily ~i~pocAhle since the needle retracts to a position that eliminates the problem of AccidPntal "needle stick" of the user or another. This device, with its self-sheathing, retracting needle, will eliminate the dangers of infection to health care workers who now sustain serious injuries from contA ;n~ted needles infected with viruses such as the hepatitis and AIDS
viruses.
WO 94/04103 / PCT/US93tO785~ ~
2~429o~
RRT~ D~ ON OF THE DRAWINGS
A better underst~n~i ng of the invention can be obt~i n~ when the detailed description of exemplary ~ -_ iments set forth below is considered in conjunction with the att~h~ drawings, in which:
Figures lA and lB are sectional views of an automatic injection device which utilizes a cam and spring - ~n i ~ to move a needle between retracted and exten~ positions;
Figure 2 is a peLD~e~ive vièw of the pre-activation position of the syringe of Fig. lA;
Figure 3 is a schematic view of an alternate embodiment of the device where a spring is used for retracting the needle;
Figure 4 is a ~ch= -tic view of the device in Fig. 3 with the needle fully ext~n~e~ and the syringe plunger fully depressed; and Figure 5 is a s~h~ -tic view of the device in Fig. 3 with the needle in a retracted position.
D~TAILED DESCRIPTION 0~ YLARY F~BODlr.~r. ~ S
Figures lA and lB show one ho~ of an automatic injection device 10 which is formed of five major components: (1) a housing 20 with an elongated section 1 and a ~arrel section 2; (2) a 51i~i~g cam me~hAnism 5; (3) a trigger me~h~nism 4; (4) a spring 9;
and (5) a syringe 11 which includes a needle 12 and a plunger 13. In general, the 51 i~i~g cam mech~ni~m 5 is slidably mounted within the elongated section 1 of the housing 20 and is powered by a spring 9. When the trigger -Ch~ni ' 4 is actuated by the user as described below, the spring 9 moves the cam -c-h~ni~ 5 from a first, loaded position to a second, unloaded position and in the process pushes the needle 12 to where it projects from the barrel section 2 (see ~ w o 94/04103 2 1 4 2 9 0 1 PC~rJUS93/0785~
Fig. 2), compresses the syringe plunger 13 to ~ i ~p~nce a drug in the syringe, and retracts the needle 12 back into the housing 20.
The barrel section 2 of the housing 20 is formed integral with and ~eL~el.dicular to the elongated ~ection 1. The elongated section 1 is hollow and is sized and designed so the sl i~ing cam - ~nism 5 can slide from a first, loaded position adjacent the trigger - Anil 4 to a reconA, unloaded position at the other end of the elongated section 1. The housing 20 may be constructed of any suitable material, such as plastic or me~al.
In one : ho~l; ment, the end of the barrel section 2 has ~-ved section 19 to mate with an individual's penis during self-injection. This shape can be changed to CO~L~ VIIA to any other anatomical shape Aep~nAing on the shape of the injection site.
A seal 18, mounted in a snap ring 18a, is placed in the outer op~ni ng of the barrel section 2 for c~l ;nq the opening and preventing foreign objects from entering the housing 20. The seal 18 can be formed of nny suitable penetrable material that can be sterilized such as neoprene rubber and is penetrated by the needle 12 when it moves to inject the drug.
The syringe 11 and the needle 12 can be provided as a component of the automatic injection device 10, as shown, where the device is used once and then ~isc~rded. ufwe~er, the automatic injection device 10 could be provided without the syringe 11 and the needle 12, which could be inserted prior to use after the cam ~-h~ni ~ 5 is loaded. In this : hoAi -nt, the device 10 would be reusable, not disposable.
The syringe 11 may be any type of syringe commonly used in the medical industry or specifically designed.
The syringe 11 has a barrel 14, a plunger 13, and a WO g4/04103 PCT/US93/07855 ~
2~,4~901 ~se~l~ 12. If the needle 12 i8 to be used for the in~ection of a drug into the penis, the needle 12 can be a 25 to 30 gauge n~eAle, designed for a~Luximately 0.25 inch penetration.
The cam --hAnil 5 is activated by the trigger - AniSm 4. The cam - AniSm 5 has a trigger engaging end 16 and a drive end 17. The trigger end 16 is deta~h~hly engaged to the trigger --hAnil 4. The spring 9 is connected between the housing 20 th uuyh a suitable spring conn~ction post 3 and to drive end 17 of the cam --hAni~ 5 t~ou~h a spring ~-ol~.æ~Lion post 22.
When the cam - ~n i 5 is loaded as shown in Fig. lA, the spring 9 is in tension. When the trigger --h~ni~ 4 is p-.che~ by the user to ~i~eng~ge it from the cam trigger end 16, the spring 9 operates to pull the 51 i~;ng cam -~hAnism 5 toward to the lnloA~e~
position at the right side of the housing 20 as shown in Figs. lA and lB.
The cam -chAni~ 5 has a first cam surface 6 which engages the top surface 15 of the syringe barrel 14 so that the syringe 11 with needle 12 is r-~h~ to the extended position shown in Fig. lB as the sl i~ing cam mechAnil 5 slides toward the unloaded position, i.e., the top surface 15 of the syringe barrel 14 follows the first cam surface 6. The cam ?ch~nism 5 has a ~econd cam surface 7 designed to interact with the syringe plunger 13 so that the syringe plunger 13 is compressed within the syringe 11 as the cam - Ani, 5 slides toward the unloaded position, i.e., the syringe plunger 13 follows the s~con~ cam surface 7.
Thus, when the cam mechanism 5 moves from the loaded position to the l-nl OA~ position, the first cam surface 6 makes contact with the top surface 15 of the WO 94/04103 21~ 2 9 0 1 PCT/US93/07855 syringe barrel 14 and the ~eCon~ cam surface 7 makes contact with the syringe plunger 13, respectively pllch i ng each ~oward the position shown in Fig. lB. As the n~D~ 1e 12 moves downwardly it first penetrates the seal 18, then the skin and into the underlying ti~6~e .
In the - ho~i - L shown in Figures lA, lB and 2, the first and ~eco~ cam surfaces 6, 7 are formed in a V-shape with the cam surface 6 (which engages the top surface 15 of the syringe) being formed at a 1 -ller angle relative to the horizontal plane of v - L than the cam surface 7 (which engages the plunger 13). This d~fferential causes the syringe 11 to be moved downwardly by the cam surface 6 to where the needle 12 has ~e.leLL~Led the patient's skin before the cam surface 7 pushes the plunger 13 relative to the syringe to inject the drug.
With this shape of the first and r?cQn~ cam surfaces 6, 7, the syringe barrel 14 and syringe plunger 13 travel in sync with each other until the needle 12 has penetrated the skin to a depth of about 0.188 in. At this point the second cam surface 7 operates to push the syringe plunger 13 at a faster rate than the first cam surface 6 is pl-~h i ng the syringe barrel 14, such that the syringe plunger 1~
forces the drug contAine~ in the syringe 11 through the needle 12 as the needle 12 continl~s to penetrate the tissue the ~. -i n; ng O .125 in. of its travel to its final position at a penetration depth of about 0.25 in.
Retraction of the syringe 11 back into the housing 20 so the needle 12 is no longer ~Ypo~e~ is accomplishe~ by providing a third following cam surface 8 on the sliding cam ~chAni~m 5 which contacts the top surface 15, which extends beyond the outer ~ Ler of the syringe barrel 14, as the sliding cam - ~AniSm 5 travels to the unloaded position. The exten~ top W O 94/04103 PC~r/US93/07855 -211~291 ' surface 15 follows the third cam surface 8, p--ll ing the syringe barrel 14 and the needle 12 into a retracted position so it cannot ~cri~entally puncture the skin of a h~n~l~.
A ~-?OOI ~ of the present invention is shown in Figs. 3, 4 and 5, where a spring 21 is used to retract the syringe barrel 14 and the ne~le 12. The cam me~hAni~ 5 is in the shape of a trapezoid (heCA~ce the following cam surface 8 shown in Figs. lA, lB has been eliminated). As the cam surfaces 6, 7 operate e~e~Lively to move the ~yringe barrel 14 and the needle 12~toward the exten~e~ position shown in Fig. 4, the syringe barrel 14 G~eL~Les to compress the spring 21.
After the syringe 11 is fully exto~ and the syringe plunger 13 d~L--ssed, the sliding cam merhAn;
While the invention is int~n~A to be used in con~unction with the administration of medicine of any physical form to various parts of the body and to various t;sCll~ depths, it is partic~lArly applicable for use in the treai - L of erectile dysf~ction.
Defined simply, erectile dy~f~ction o~urD when a male is unable to maintain adequate p~ni le rigidity n~c~cff~ry to initiate, sustain and ~ cessfully c~n -te the act of coitus. It denotes organic impotence.
This condition can be a psychologically devastating therapeutic problem. It has been estimated to effect 50% of all diabetic men and up to 9% of y~ullye~ men in apparent good health. Varying degrees of erectile dysfunction c~-~ce~ by age, drug use, arteriosclerosis, trauma, hr _ ? disorders and surgical ~Loce.1..es have also been observed.
Di~inich~ male erectile l~X~Ol'~e iS the limiting factor in 5~al relationch;rs. The fear of erectile failure has been La~oLLed as one of the primary reACQn~
for decreased libido in older males.
The penile erection - An i ~ _ of the ,.~, -1 male is a complex interaction of hormones, n~u ~L~ansmitters and blood v~cs~ls. An erection begins when paired penile arteries dilate in reCpo~ce to neuLu~ansmitters rel~Y; ng the smooth muscle walls of the arteries. An increased inC i~ blood flow e~ Lyes the ~h: h~r5 of the penis (~u-~ra cavernosa) where it is LL~ed. The tough and fibrous encasing tunica albuginea is stretched by tur-~ re and c~ _esses perforating veins which drain the blood filled ~hr h~r5 . Venous drainage is impeded and further penile rigidity ~n In organic impotent males, this vA~c1~lAr-erection ?chAnis~ is substantially impaired, not activated or not intact.
2 1 ~ 2 9 0 1 Self-injection of vasoactive pharmacotherapeutic agents directly into the penis for treatment of erectile ~y~fu~-ction is known. Intraca~e ,.~us p~a~line, phentolamine and prostagl An~ i n El frequently are used indivi ~ 1 ly or in synergistic mi~Lu~Ls to replace the absent n~u~LL~nsmitter mediated v~c~ r dilatation and ~lhC~quent physiologic erection. Nitric oxide or a natural neulo L.~nsmitter-ho- ?, vasoactive intestinal peptide, may be the fuLu,e vasoactive agents of choice.
While clinical ~-ccesc with intra c~v~ ..uus pharmacotherapy ~Y~e~C 75%, many patients do not initiate or Al~n~n self-injection therapy once it has been tried. The most common reason self-injection is not used is a universal phobia of illL,G~ cing a needle into one's penis. Other r~CQ~c include on older patient's ineptitude, manual tremors and loss of dexterity n~c~csAry to locate injection site; physical hAndicaps of blin~n~fifi, loss of limb and abdominal obesity; tra~ urLation inc~nv~,,ience; prolonged Gyringe needle-vial drawing t~hn iques; lack of .~.,Laneity during love ~kinq; objections from ~
partner; and lack of self-injection confi~n~e, plus the natural apprehensions that professional assistance is required to avoid hemorrhage or priapism.
Various types of syringes have been developed for injecting drugs into the penis or for self-administration of drugs into other parts of the body.
These devices, which have proved ineffective for various reasons, include the one shown in U.S. patent 4,150,669 to Latorre. A dual hypodermic needle syringe for injecting fluids into the penis is shown, which has two parallel, inte~.o. .ected barrels çonnected to needles exten~ing from the barrels. This device has the disadvantage that the syringe needles must be W O 94/04103 PC~r/US93/07855 ~
21~29l ~ y il---u3-~-e~ into the penis and manual depression of the plunger(s) is re~uired to inject the me~icinAl fluid from the syringe and ne~le into the penis.
Various forms of spri.. ~ e~!irpe~ syringe holders and actustors are known, such as the ones snown in U.S.
patents 3,941,130 (Tibbs), 4,261,358 (Vargas et al.) and 4,188,950 (Wardlaw). ~rJ_~., these devices do not utilize a ~ch~ni ! which allows for automatic insertion of the nee~l~, injection of the fluid, and retraction of the needle provided in a _ -ct, discrete device.
Thus, there exists the need for an automatic injection device which allows easy and accurate self-injection of medication. This need is partic~ rlyacute in the self-injection of medication into one's penis where there is the additi OnA 1 need of keeping the needle hi~Pn from view to eliminate nee~leCc anxiety.
SUMMARY OF THE lNv~llON
The invention relates to ~n automatic injection device, which upon activation by the user, automatically i,.~.Gllces a needle into an individual, injects the medication cont~i n~ in the syringe and then retracts the needle from the individual. While the present invention relates to injection into any body part and to any depth, i.e., intradermal, subcutaneous, or intr~ Cc~l A r, the preferred : ho~i -nt relates to direct, automatic injection of medication into the penis for treatment of male erectile dy~fullction.
The automatic injection device has a housing with a 51 i~;nq cam - `~n;~ which is powered by an exte~e~
spring and activated by a trigger - Anism. The housing has an integral barrel section located 21~2~01 WO 94/04tO3 ^ PCT/US93/07855 ~e~lJr~ r to the path of the slidin~ cam me~h~nism which contains a syringe with needle. Upon activation, one surface of the sl;~;ng cam me~h~nism contacts the syringe, pllchjng the syringe from its initial position to an ex~en~^~ position such that the needle is inserted into the individual. A secQn~ surface of the sli~ing cam ~-hAni~ p~cheR the syringe plunger for administering fluid cont~inP~ in the syringe into the individual. The needle is then automatically retracted within the barrel such that the needle remains h i dd from sight.
The present invention provides an automatic injection device which will inject medication with an llnQ~n needle, thus overcoming an individual's fear of neèdles while providing conv~n;~ce and the ~o~e-dosage.
The present invention also provides a useful device which makes self-injection of medication into the penis for cases of erectile dy~ru~lction a relatively simply procedure. The device allows easy and correct placement with a h i ~n needle that automatically penetrates, injects medication and retracts.
The device is compact, discrete, and easily ~i~pocAhle since the needle retracts to a position that eliminates the problem of AccidPntal "needle stick" of the user or another. This device, with its self-sheathing, retracting needle, will eliminate the dangers of infection to health care workers who now sustain serious injuries from contA ;n~ted needles infected with viruses such as the hepatitis and AIDS
viruses.
WO 94/04103 / PCT/US93tO785~ ~
2~429o~
RRT~ D~ ON OF THE DRAWINGS
A better underst~n~i ng of the invention can be obt~i n~ when the detailed description of exemplary ~ -_ iments set forth below is considered in conjunction with the att~h~ drawings, in which:
Figures lA and lB are sectional views of an automatic injection device which utilizes a cam and spring - ~n i ~ to move a needle between retracted and exten~ positions;
Figure 2 is a peLD~e~ive vièw of the pre-activation position of the syringe of Fig. lA;
Figure 3 is a schematic view of an alternate embodiment of the device where a spring is used for retracting the needle;
Figure 4 is a ~ch= -tic view of the device in Fig. 3 with the needle fully ext~n~e~ and the syringe plunger fully depressed; and Figure 5 is a s~h~ -tic view of the device in Fig. 3 with the needle in a retracted position.
D~TAILED DESCRIPTION 0~ YLARY F~BODlr.~r. ~ S
Figures lA and lB show one ho~ of an automatic injection device 10 which is formed of five major components: (1) a housing 20 with an elongated section 1 and a ~arrel section 2; (2) a 51i~i~g cam me~hAnism 5; (3) a trigger me~h~nism 4; (4) a spring 9;
and (5) a syringe 11 which includes a needle 12 and a plunger 13. In general, the 51 i~i~g cam mech~ni~m 5 is slidably mounted within the elongated section 1 of the housing 20 and is powered by a spring 9. When the trigger -Ch~ni ' 4 is actuated by the user as described below, the spring 9 moves the cam -c-h~ni~ 5 from a first, loaded position to a second, unloaded position and in the process pushes the needle 12 to where it projects from the barrel section 2 (see ~ w o 94/04103 2 1 4 2 9 0 1 PC~rJUS93/0785~
Fig. 2), compresses the syringe plunger 13 to ~ i ~p~nce a drug in the syringe, and retracts the needle 12 back into the housing 20.
The barrel section 2 of the housing 20 is formed integral with and ~eL~el.dicular to the elongated ~ection 1. The elongated section 1 is hollow and is sized and designed so the sl i~ing cam - ~nism 5 can slide from a first, loaded position adjacent the trigger - Anil 4 to a reconA, unloaded position at the other end of the elongated section 1. The housing 20 may be constructed of any suitable material, such as plastic or me~al.
In one : ho~l; ment, the end of the barrel section 2 has ~-ved section 19 to mate with an individual's penis during self-injection. This shape can be changed to CO~L~ VIIA to any other anatomical shape Aep~nAing on the shape of the injection site.
A seal 18, mounted in a snap ring 18a, is placed in the outer op~ni ng of the barrel section 2 for c~l ;nq the opening and preventing foreign objects from entering the housing 20. The seal 18 can be formed of nny suitable penetrable material that can be sterilized such as neoprene rubber and is penetrated by the needle 12 when it moves to inject the drug.
The syringe 11 and the needle 12 can be provided as a component of the automatic injection device 10, as shown, where the device is used once and then ~isc~rded. ufwe~er, the automatic injection device 10 could be provided without the syringe 11 and the needle 12, which could be inserted prior to use after the cam ~-h~ni ~ 5 is loaded. In this : hoAi -nt, the device 10 would be reusable, not disposable.
The syringe 11 may be any type of syringe commonly used in the medical industry or specifically designed.
The syringe 11 has a barrel 14, a plunger 13, and a WO g4/04103 PCT/US93/07855 ~
2~,4~901 ~se~l~ 12. If the needle 12 i8 to be used for the in~ection of a drug into the penis, the needle 12 can be a 25 to 30 gauge n~eAle, designed for a~Luximately 0.25 inch penetration.
The cam --hAnil 5 is activated by the trigger - AniSm 4. The cam - AniSm 5 has a trigger engaging end 16 and a drive end 17. The trigger end 16 is deta~h~hly engaged to the trigger --hAnil 4. The spring 9 is connected between the housing 20 th uuyh a suitable spring conn~ction post 3 and to drive end 17 of the cam --hAni~ 5 t~ou~h a spring ~-ol~.æ~Lion post 22.
When the cam - ~n i 5 is loaded as shown in Fig. lA, the spring 9 is in tension. When the trigger --h~ni~ 4 is p-.che~ by the user to ~i~eng~ge it from the cam trigger end 16, the spring 9 operates to pull the 51 i~;ng cam -~hAnism 5 toward to the lnloA~e~
position at the right side of the housing 20 as shown in Figs. lA and lB.
The cam -chAni~ 5 has a first cam surface 6 which engages the top surface 15 of the syringe barrel 14 so that the syringe 11 with needle 12 is r-~h~ to the extended position shown in Fig. lB as the sl i~ing cam mechAnil 5 slides toward the unloaded position, i.e., the top surface 15 of the syringe barrel 14 follows the first cam surface 6. The cam ?ch~nism 5 has a ~econd cam surface 7 designed to interact with the syringe plunger 13 so that the syringe plunger 13 is compressed within the syringe 11 as the cam - Ani, 5 slides toward the unloaded position, i.e., the syringe plunger 13 follows the s~con~ cam surface 7.
Thus, when the cam mechanism 5 moves from the loaded position to the l-nl OA~ position, the first cam surface 6 makes contact with the top surface 15 of the WO 94/04103 21~ 2 9 0 1 PCT/US93/07855 syringe barrel 14 and the ~eCon~ cam surface 7 makes contact with the syringe plunger 13, respectively pllch i ng each ~oward the position shown in Fig. lB. As the n~D~ 1e 12 moves downwardly it first penetrates the seal 18, then the skin and into the underlying ti~6~e .
In the - ho~i - L shown in Figures lA, lB and 2, the first and ~eco~ cam surfaces 6, 7 are formed in a V-shape with the cam surface 6 (which engages the top surface 15 of the syringe) being formed at a 1 -ller angle relative to the horizontal plane of v - L than the cam surface 7 (which engages the plunger 13). This d~fferential causes the syringe 11 to be moved downwardly by the cam surface 6 to where the needle 12 has ~e.leLL~Led the patient's skin before the cam surface 7 pushes the plunger 13 relative to the syringe to inject the drug.
With this shape of the first and r?cQn~ cam surfaces 6, 7, the syringe barrel 14 and syringe plunger 13 travel in sync with each other until the needle 12 has penetrated the skin to a depth of about 0.188 in. At this point the second cam surface 7 operates to push the syringe plunger 13 at a faster rate than the first cam surface 6 is pl-~h i ng the syringe barrel 14, such that the syringe plunger 1~
forces the drug contAine~ in the syringe 11 through the needle 12 as the needle 12 continl~s to penetrate the tissue the ~. -i n; ng O .125 in. of its travel to its final position at a penetration depth of about 0.25 in.
Retraction of the syringe 11 back into the housing 20 so the needle 12 is no longer ~Ypo~e~ is accomplishe~ by providing a third following cam surface 8 on the sliding cam ~chAni~m 5 which contacts the top surface 15, which extends beyond the outer ~ Ler of the syringe barrel 14, as the sliding cam - ~AniSm 5 travels to the unloaded position. The exten~ top W O 94/04103 PC~r/US93/07855 -211~291 ' surface 15 follows the third cam surface 8, p--ll ing the syringe barrel 14 and the needle 12 into a retracted position so it cannot ~cri~entally puncture the skin of a h~n~l~.
A ~-?OOI ~ of the present invention is shown in Figs. 3, 4 and 5, where a spring 21 is used to retract the syringe barrel 14 and the ne~le 12. The cam me~hAni~ 5 is in the shape of a trapezoid (heCA~ce the following cam surface 8 shown in Figs. lA, lB has been eliminated). As the cam surfaces 6, 7 operate e~e~Lively to move the ~yringe barrel 14 and the needle 12~toward the exten~e~ position shown in Fig. 4, the syringe barrel 14 G~eL~Les to compress the spring 21.
After the syringe 11 is fully exto~ and the syringe plunger 13 d~L--ssed, the sliding cam merhAn;
5 is located in the position shown in Fig. 5 where it is no longer in contact with the syringe 11. The retraction spring 21 is then free to 1~L~L1I to its r _ , _ essed position, operating to automatically retract the syringe ll with needle 12 into the barrel section 2.
The automatic injection device ~olves the problems mentioned above by providing a compact, discrete device which allows easy and accurate automatic self-injection of medication without the apprehension of viewing the needle. When the drug has been injected, the needle is automatically retracted into the housing 20 so that the possibility of an accidental ~u~ uLe with the needle is eli in~ted.
Having described the invention above, various modifications of the techniques, prore~l~es, material and e~uipment will be apparent to those skilled in the art. It is intended that all such variations within ~ WO 94/04103 2 1 4 2 ~ ~ 1 PCT/US93/07855 the scope and spirit of the invention be included within the scope of the App~n~ claims.
The automatic injection device ~olves the problems mentioned above by providing a compact, discrete device which allows easy and accurate automatic self-injection of medication without the apprehension of viewing the needle. When the drug has been injected, the needle is automatically retracted into the housing 20 so that the possibility of an accidental ~u~ uLe with the needle is eli in~ted.
Having described the invention above, various modifications of the techniques, prore~l~es, material and e~uipment will be apparent to those skilled in the art. It is intended that all such variations within ~ WO 94/04103 2 1 4 2 ~ ~ 1 PCT/US93/07855 the scope and spirit of the invention be included within the scope of the App~n~ claims.
Claims
What is claimed is:
1. An apparatus for injecting a medicament, comprising:
(a) a housing;
(b) a syringe having a syringe barrel for holding a medicament, a plunger movable within the barrel for ejecting the medicament from the barrel, and a hollow needle communicating with the barrel for transporting the medicament from the barrel to a patient;
(c) mounting means for mounting the syringe in the housing and enabling the syringe to move from a first retracted position to a second extended position for injecting the medicament;
(d) movement and injection means for moving the syringe from the first to the second position and pushing the plunger for injecting the medicament after the syringe has moved at least toward the second position;
(e) retracting means for moving the syringe back to the first retracted position after the medicament has been injected wherein the housing has a first portion for holding the syringe and a second portion, perpendicular to the first portion, for holding the movement and injection means.
3. The apparatus of claim 1, wherein the syringe barrel has an upper surface and the plunger projects from the upper surface and wherein the movement and injection means comprises a cam with a first surface and a second surface for respectively engaging the upper surface and the plunger.
4. The apparatus of claim 3, wherein the movement and injection means further comprises a spring connected to the cam for moving the cam.
5. The apparatus of claim 3, wherein the upper surface has a rim projecting beyond the outer surface of the syringe barrel and the cam has a follower surface for engaging the rim for retracting the syringe into the housing.
6. The apparatus of claim 1, wherein the retracting means comprises a spring located in the first portion of the housing for retracting the syringe into the housing.
7. The apparatus of claim 1, wherein the first portion of the housing has an opening sealed with material capable of being penetrated by the needle.
8. The apparatus of claim 1, wherein the retracting means fully retracts the needle into the first portion of the housing.
9. An injection device for injection of fluid, comprising:
a housing having an elongated section and a barrel section, said elongated section elongated in the direction of an axis, the barrel section integral with the elongated section and perpendicular to the axis, a spring attachment connection at an end of said housing along the axis, and a trigger mechanism at an opposite end of said housing along the axis;
a sliding cam mechanism slidably mounted within said housing to slide in the direction of the axis, having a first cam surface, a second cam surface, a third cam surface, a drive end, and a trigger end, said trigger end designed to detachably engage said trigger mechanism; and a spring having a first end and a second end, the first end fixedly attached to said spring attachment connection, the second end fixedly connected to the drive end of the sliding cam mechanism.
10. The injection device of claim 9, further comprising:
a syringe with needle, slidably located within said barrel section, said syringe having a syringe barrel and a syringe plunger, said syringe barrel having a top surface, said top surface located adjacent to the first cam surface so as to follow the first cam surface and located so as to contact the third cam surface and follow the third cam surface, said syringe plunger located adjacent to the second cam surface so as to follow the second cam surface.
11. The injection device of claim 9, wherein the injection device is for injection of liquid into a penis.
12. The injection device of claim 11, wherein the barrel section has a curved end section for mating with a penis.
13. The injection device of claim 12, wherein the needle is designed for a predetermined depth of penetration into the penis.
14. The injection device of claim 13, wherein the needle is an approximately 25 to 30 gauge needle, designed for approximately 0.25 inch penetration into the penis.
15. The injection device of claim 10, wherein the injection device is for injection of liquid into a penis.
16. The injection device of claim 15, wherein the barrel section has a curved end section for mating with a penis.
17. The injection device of claim 16, wherein the needle is designed for a predetermined depth of penetration into the penis.
18. The injection device of claim 17, wherein the needle is an approximately 25 to 30 gauge needle, designed for approximately 0.25 inch penetration into the penis.
19. An injection device for injection of fluid, comprising:
a housing having an elongated section and a barrel section, said elongated section elongated in the direction of an axis, the barrel section integral with the elongated section and perpendicular to the axis, a spring attachment connection at an end of said housing along the axis, and a trigger mechanism at an opposite end of said housing along the axis;
a sliding cam mechanism slidably mounted within said housing to slide in the direction of the axis, having a first cam surface, a second cam surface, a drive end, and a trigger end, said trigger end designed to detachably engage said trigger mechanism; and a spring having a first end and a second end, the first end fixedly attached to said spring attachment connection, the second end fixedly connected to the drive end of the sliding cam mechanism.
20. The injection device of claim 19, further comprising:
a syringe with needle, slidable located within said barrel section, said syringe having a syringe barrel and a syringe plunger, said syringe barrel having a top surface, said top surface located adjacent to the first cam surface so as to follow the first cam surface, said syringe plunger located adjacent to the second cam surface so as to follow the second cam surface; and a retraction spring located within the barrel section so as to push the syringe with needle to a retracted position.
21. The injection device of claim 19, wherein the injection device is for injection of liquid into a penis.
22. The injection device of claim 21, wherein the barrel section has a curved end section for mating with a penis.
23. The injection device of claim 22, wherein the needle is designed for a predetermined depth of penetration into the penis.
24. The injection device of claim 23, wherein the needle is an approximately 25 to 30 gauge needle, designed for approximately 0.25 inch penetration into the penis.
25. The injection device of claim 20, wherein the injection device is for injection of liquid into a penis.
26. The injection device of claim 25, wherein the barrel section has a curved end section for mating with a penis.
27. The injection device of claim 26, wherein the needle is designed for a predetermined depth of penetration into the penis.
28. The injection device of claim 27, wherein the needle is an approximately 25 to 30 gauge needle, designed for approximately 0.25 inch penetration into the penis.
1. An apparatus for injecting a medicament, comprising:
(a) a housing;
(b) a syringe having a syringe barrel for holding a medicament, a plunger movable within the barrel for ejecting the medicament from the barrel, and a hollow needle communicating with the barrel for transporting the medicament from the barrel to a patient;
(c) mounting means for mounting the syringe in the housing and enabling the syringe to move from a first retracted position to a second extended position for injecting the medicament;
(d) movement and injection means for moving the syringe from the first to the second position and pushing the plunger for injecting the medicament after the syringe has moved at least toward the second position;
(e) retracting means for moving the syringe back to the first retracted position after the medicament has been injected wherein the housing has a first portion for holding the syringe and a second portion, perpendicular to the first portion, for holding the movement and injection means.
3. The apparatus of claim 1, wherein the syringe barrel has an upper surface and the plunger projects from the upper surface and wherein the movement and injection means comprises a cam with a first surface and a second surface for respectively engaging the upper surface and the plunger.
4. The apparatus of claim 3, wherein the movement and injection means further comprises a spring connected to the cam for moving the cam.
5. The apparatus of claim 3, wherein the upper surface has a rim projecting beyond the outer surface of the syringe barrel and the cam has a follower surface for engaging the rim for retracting the syringe into the housing.
6. The apparatus of claim 1, wherein the retracting means comprises a spring located in the first portion of the housing for retracting the syringe into the housing.
7. The apparatus of claim 1, wherein the first portion of the housing has an opening sealed with material capable of being penetrated by the needle.
8. The apparatus of claim 1, wherein the retracting means fully retracts the needle into the first portion of the housing.
9. An injection device for injection of fluid, comprising:
a housing having an elongated section and a barrel section, said elongated section elongated in the direction of an axis, the barrel section integral with the elongated section and perpendicular to the axis, a spring attachment connection at an end of said housing along the axis, and a trigger mechanism at an opposite end of said housing along the axis;
a sliding cam mechanism slidably mounted within said housing to slide in the direction of the axis, having a first cam surface, a second cam surface, a third cam surface, a drive end, and a trigger end, said trigger end designed to detachably engage said trigger mechanism; and a spring having a first end and a second end, the first end fixedly attached to said spring attachment connection, the second end fixedly connected to the drive end of the sliding cam mechanism.
10. The injection device of claim 9, further comprising:
a syringe with needle, slidably located within said barrel section, said syringe having a syringe barrel and a syringe plunger, said syringe barrel having a top surface, said top surface located adjacent to the first cam surface so as to follow the first cam surface and located so as to contact the third cam surface and follow the third cam surface, said syringe plunger located adjacent to the second cam surface so as to follow the second cam surface.
11. The injection device of claim 9, wherein the injection device is for injection of liquid into a penis.
12. The injection device of claim 11, wherein the barrel section has a curved end section for mating with a penis.
13. The injection device of claim 12, wherein the needle is designed for a predetermined depth of penetration into the penis.
14. The injection device of claim 13, wherein the needle is an approximately 25 to 30 gauge needle, designed for approximately 0.25 inch penetration into the penis.
15. The injection device of claim 10, wherein the injection device is for injection of liquid into a penis.
16. The injection device of claim 15, wherein the barrel section has a curved end section for mating with a penis.
17. The injection device of claim 16, wherein the needle is designed for a predetermined depth of penetration into the penis.
18. The injection device of claim 17, wherein the needle is an approximately 25 to 30 gauge needle, designed for approximately 0.25 inch penetration into the penis.
19. An injection device for injection of fluid, comprising:
a housing having an elongated section and a barrel section, said elongated section elongated in the direction of an axis, the barrel section integral with the elongated section and perpendicular to the axis, a spring attachment connection at an end of said housing along the axis, and a trigger mechanism at an opposite end of said housing along the axis;
a sliding cam mechanism slidably mounted within said housing to slide in the direction of the axis, having a first cam surface, a second cam surface, a drive end, and a trigger end, said trigger end designed to detachably engage said trigger mechanism; and a spring having a first end and a second end, the first end fixedly attached to said spring attachment connection, the second end fixedly connected to the drive end of the sliding cam mechanism.
20. The injection device of claim 19, further comprising:
a syringe with needle, slidable located within said barrel section, said syringe having a syringe barrel and a syringe plunger, said syringe barrel having a top surface, said top surface located adjacent to the first cam surface so as to follow the first cam surface, said syringe plunger located adjacent to the second cam surface so as to follow the second cam surface; and a retraction spring located within the barrel section so as to push the syringe with needle to a retracted position.
21. The injection device of claim 19, wherein the injection device is for injection of liquid into a penis.
22. The injection device of claim 21, wherein the barrel section has a curved end section for mating with a penis.
23. The injection device of claim 22, wherein the needle is designed for a predetermined depth of penetration into the penis.
24. The injection device of claim 23, wherein the needle is an approximately 25 to 30 gauge needle, designed for approximately 0.25 inch penetration into the penis.
25. The injection device of claim 20, wherein the injection device is for injection of liquid into a penis.
26. The injection device of claim 25, wherein the barrel section has a curved end section for mating with a penis.
27. The injection device of claim 26, wherein the needle is designed for a predetermined depth of penetration into the penis.
28. The injection device of claim 27, wherein the needle is an approximately 25 to 30 gauge needle, designed for approximately 0.25 inch penetration into the penis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US934,014 | 1986-11-24 | ||
US07/934,014 US5267963A (en) | 1992-08-21 | 1992-08-21 | Medication injection device |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2142901A1 true CA2142901A1 (en) | 1994-03-03 |
Family
ID=25464812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002142901A Abandoned CA2142901A1 (en) | 1992-08-21 | 1993-08-20 | Medication injection device |
Country Status (13)
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US (1) | US5267963A (en) |
EP (1) | EP0655899A4 (en) |
JP (1) | JPH08502180A (en) |
KR (1) | KR950702845A (en) |
CN (1) | CN1083395A (en) |
AU (1) | AU671861B2 (en) |
BR (1) | BR9306926A (en) |
CA (1) | CA2142901A1 (en) |
EC (1) | ECSP930974A (en) |
MX (1) | MX9300089A (en) |
TW (1) | TW235923B (en) |
WO (1) | WO1994004103A1 (en) |
ZA (1) | ZA936084B (en) |
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-
1992
- 1992-08-21 US US07/934,014 patent/US5267963A/en not_active Expired - Fee Related
-
1993
- 1993-01-08 MX MX9300089A patent/MX9300089A/en unknown
- 1993-08-19 ZA ZA936084A patent/ZA936084B/en unknown
- 1993-08-20 CA CA002142901A patent/CA2142901A1/en not_active Abandoned
- 1993-08-20 EP EP93920251A patent/EP0655899A4/en not_active Withdrawn
- 1993-08-20 JP JP6506557A patent/JPH08502180A/en active Pending
- 1993-08-20 BR BR9306926A patent/BR9306926A/en not_active IP Right Cessation
- 1993-08-20 EC EC1993000974A patent/ECSP930974A/en unknown
- 1993-08-20 WO PCT/US1993/007855 patent/WO1994004103A1/en not_active Application Discontinuation
- 1993-08-20 KR KR1019950700669A patent/KR950702845A/en active IP Right Grant
- 1993-08-20 AU AU50843/93A patent/AU671861B2/en not_active Ceased
- 1993-08-21 TW TW082106759A patent/TW235923B/zh active
- 1993-08-21 CN CN93116451A patent/CN1083395A/en active Pending
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AU5084393A (en) | 1994-03-15 |
WO1994004103A1 (en) | 1994-03-03 |
AU671861B2 (en) | 1996-09-12 |
KR950702845A (en) | 1995-08-23 |
MX9300089A (en) | 1994-02-28 |
BR9306926A (en) | 1999-01-12 |
EP0655899A4 (en) | 1995-09-13 |
CN1083395A (en) | 1994-03-09 |
JPH08502180A (en) | 1996-03-12 |
EP0655899A1 (en) | 1995-06-07 |
US5267963A (en) | 1993-12-07 |
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ZA936084B (en) | 1994-03-14 |
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FZDE | Dead |