CA2141451A1 - Photoactivatable chemiluminescent matrices - Google Patents

Photoactivatable chemiluminescent matrices

Info

Publication number
CA2141451A1
CA2141451A1 CA002141451A CA2141451A CA2141451A1 CA 2141451 A1 CA2141451 A1 CA 2141451A1 CA 002141451 A CA002141451 A CA 002141451A CA 2141451 A CA2141451 A CA 2141451A CA 2141451 A1 CA2141451 A1 CA 2141451A1
Authority
CA
Canada
Prior art keywords
analyte
photosensitizer
matrix
methods
chemiluminescent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002141451A
Other languages
French (fr)
Other versions
CA2141451C (en
Inventor
John S. Pease
Hrair Kirakossian
Daniel B. Wagner
Edwin F. Ullman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
John S. Pease
Hrair Kirakossian
Daniel B. Wagner
Edwin F. Ullman
Syntex (U.S.A.) Inc.
Behringwerke Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John S. Pease, Hrair Kirakossian, Daniel B. Wagner, Edwin F. Ullman, Syntex (U.S.A.) Inc., Behringwerke Aktiengesellschaft filed Critical John S. Pease
Publication of CA2141451A1 publication Critical patent/CA2141451A1/en
Application granted granted Critical
Publication of CA2141451C publication Critical patent/CA2141451C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/905—Photochemical activation of reactions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Abstract

Methods for labeling a material are disclosed. The methods comprise combining with the material (a) a photosensitizer capable upon irradiation of generating singlet oxygen and (b) a chemiluminescent compound capable of being activated by sing-let oxygen wherein the photosensitizer and the chemiluminescent compound are incorporated in a particulate matrix or a non-particulate solid matrix. The particulate matrix can be solid or fluid. The methods allow for generating delayed luminescence, which can be realized upon irradiation of the matrix. The methods have application to the determination of an analyte in a medi-um suspected of containing the analyte. One method comprises subjecting a medium suspected of containing an analyte to condi-tions under which a complex of specific binding pair (sbp) members is formed in relation to the presence of the analyte and deter-mining whether the sbp member complex has formed by employing as a label a single composition having both chemiluminescent and photosensitizer properties. Upon activation of the photosensitizer property singlet oxygen is generated and activates the chemiluminescent property. Compositions and kits are also disclosed.
CA002141451A 1992-07-31 1993-07-30 Photoactivatable chemiluminescent matrices Expired - Fee Related CA2141451C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92306992A 1992-07-31 1992-07-31
US923,069 1992-07-31
PCT/US1993/007052 WO1994003812A1 (en) 1992-07-31 1993-07-30 Photoactivatable chemiluminescent matrices

Publications (2)

Publication Number Publication Date
CA2141451A1 true CA2141451A1 (en) 1994-02-17
CA2141451C CA2141451C (en) 2003-10-07

Family

ID=25448070

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002141451A Expired - Fee Related CA2141451C (en) 1992-07-31 1993-07-30 Photoactivatable chemiluminescent matrices

Country Status (9)

Country Link
US (2) US5618732A (en)
EP (1) EP0653066B1 (en)
JP (1) JP3464798B2 (en)
AT (1) ATE162892T1 (en)
CA (1) CA2141451C (en)
DE (1) DE69316757T2 (en)
DK (1) DK0653066T3 (en)
ES (1) ES2113547T3 (en)
WO (1) WO1994003812A1 (en)

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JP3464798B2 (en) 2003-11-10
US5709994A (en) 1998-01-20
EP0653066A1 (en) 1995-05-17
CA2141451C (en) 2003-10-07
ES2113547T3 (en) 1998-05-01
DE69316757D1 (en) 1998-03-05
JPH09502253A (en) 1997-03-04
WO1994003812A1 (en) 1994-02-17
US5618732A (en) 1997-04-08
DK0653066T3 (en) 1998-09-23
DE69316757T2 (en) 1998-05-07
ATE162892T1 (en) 1998-02-15

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