CA2139864A1 - Utilisation d'un materiau poreux a base de carbonate de calcium comme support pour un facteur de croissance dans la preparation d'un implant bioresorbable - Google Patents
Utilisation d'un materiau poreux a base de carbonate de calcium comme support pour un facteur de croissance dans la preparation d'un implant bioresorbableInfo
- Publication number
- CA2139864A1 CA2139864A1 CA002139864A CA2139864A CA2139864A1 CA 2139864 A1 CA2139864 A1 CA 2139864A1 CA 002139864 A CA002139864 A CA 002139864A CA 2139864 A CA2139864 A CA 2139864A CA 2139864 A1 CA2139864 A1 CA 2139864A1
- Authority
- CA
- Canada
- Prior art keywords
- support
- calcium carbonate
- carbonate based
- growth factor
- bioabsorbable implant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/10—Mineral substrates
- C12N2533/18—Calcium salts, e.g. apatite, Mineral components from bones, teeth, shells
Abstract
2139864 9426322 Utilisation d'un matériau poreux à base de carbonate de calcium comme support pour au moins un facteur de croissance dans la préparation d'un implant biorésorbable destiné à être mis en place dans un organisme animal vivant, en particulier chez un animal vertébré. Avec un facteur de croissance ostéoinducteur, l'implant peut constituer une pièce de comblement osseux, ou peut être implanté dans un tissu conjonctif où il donnera naissance à un tissu osseux utilisable comme autogreffe. Avec un facteur de croissance non ostéoinducteur, l'implant peut servir à cultiver des cellules in vivo. On peut par exemple utiliser un implant creux dans lequel on introduit des cellules autologues modifiées, notamment par insertion d'un gène. Après mise en place, l'implant constitue un organoïde permettant par exemple de remédier à un dysfonctionnement d'origine génétique.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR93/05783 | 1993-05-13 | ||
FR9305783A FR2705235B1 (fr) | 1993-05-13 | 1993-05-13 | Utilisation de particules d'un sel de calcium biocompatible et biorésorbable comme ingrédient actif dans la préparation d'un médicament destiné au traitement local des maladies déminéralisantes de l'os. |
FR9313740A FR2706768B1 (fr) | 1993-05-13 | 1993-11-17 | |
FR93/13740 | 1993-11-17 | ||
PCT/FR1994/000565 WO1994026322A1 (fr) | 1993-05-13 | 1994-05-11 | Utilisation d'un materiau poreux a base de carbonate de calcium comme support pour un facteur de croissance dans la preparation d'un implant bioresorbable |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2139864A1 true CA2139864A1 (fr) | 1994-11-24 |
CA2139864C CA2139864C (fr) | 2003-07-15 |
Family
ID=26230324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002139864A Expired - Fee Related CA2139864C (fr) | 1993-05-13 | 1994-05-11 | Utilisation d'un materiau poreux a base de carbonate de calcium comme support pour un facteur de croissance dans la preparation d'un implant bioresorbable |
Country Status (13)
Country | Link |
---|---|
US (1) | US5711957A (fr) |
EP (1) | EP0650374B1 (fr) |
JP (1) | JP2957281B2 (fr) |
AT (1) | ATE194922T1 (fr) |
AU (1) | AU676056B2 (fr) |
CA (1) | CA2139864C (fr) |
DE (1) | DE69425358T2 (fr) |
DK (1) | DK0650374T3 (fr) |
ES (1) | ES2150492T3 (fr) |
FR (1) | FR2706768B1 (fr) |
GR (1) | GR3034667T3 (fr) |
PT (1) | PT650374E (fr) |
WO (1) | WO1994026322A1 (fr) |
Families Citing this family (68)
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US20030077825A1 (en) * | 1994-07-22 | 2003-04-24 | Bhatnagar Rajendra S. | Structures useful for bone engineering and methods |
US5563124A (en) * | 1991-04-22 | 1996-10-08 | Intermedics Orthopedics/ Denver, Inc. | Osteogenic product and process |
FR2737850A1 (fr) * | 1995-08-14 | 1997-02-21 | Biomat | Produit de revetement pour prothese |
FR2737851B1 (fr) * | 1995-08-14 | 1997-10-24 | Biomat | Produit de revetement pour prothese |
FR2743496B1 (fr) * | 1996-01-15 | 1998-04-10 | Univ Rennes | Composite macroporeux support de substance(s) medicamenteuse(s) utilisable comme materiau de reconstitution osseuse et procede d'elaboration |
EP0883410B1 (fr) * | 1996-02-29 | 2004-08-18 | Bioactive Bone Substitute OY, AB | Dispositif osteogenique et son procede de preparation |
CA2235655C (fr) * | 1997-04-24 | 2008-01-22 | Sunstar Inc. | Compositions orales comprenant un carbonate de calcium poreux |
US20030147860A1 (en) | 2002-02-07 | 2003-08-07 | Marchosky J. Alexander | Compositions and methods for forming and strengthening bone |
US6432710B1 (en) * | 1998-05-22 | 2002-08-13 | Isolagen Technologies, Inc. | Compositions for regenerating tissue that has deteriorated, and methods for using such compositions |
AU4093399A (en) * | 1998-05-22 | 1999-12-13 | Isolagen Technologies, Inc. | Compositions for regenerating tissue that has degenerated, and methods for using such compositions |
WO1999060837A2 (fr) * | 1998-05-27 | 1999-12-02 | Nuvasive, Inc. | Butees osseuses et insertion de butees osseuses dans les espaces intervertebraux |
WO1999060956A1 (fr) | 1998-05-27 | 1999-12-02 | Nuvasive, Inc. | Interblocage d'inserts rachidiens |
WO1999060957A1 (fr) | 1998-05-27 | 1999-12-02 | Nuvasive, Inc. | Procedes et appareil permettant de separer et de stabiliser des vertebres adjacentes |
GB9823307D0 (en) | 1998-10-23 | 1998-12-23 | Regent Genus Organisms Interna | Composition for traetment of periodontopathy and related diseases |
EP1253854A4 (fr) * | 1999-03-07 | 2010-01-06 | Discure Ltd | Procede et appareil de chirurgie informatisee |
WO2000054821A1 (fr) * | 1999-03-16 | 2000-09-21 | Regeneration Technologies, Inc. | Implants moules pour applications orthopediques |
AU782394B2 (en) | 1999-06-29 | 2005-07-21 | J. Alexander Marchosky | Compositions and methods for forming and strengthening bone |
DE19944681A1 (de) * | 1999-08-20 | 2001-03-01 | Metz Stavenhagen Peter | Knochenersatzstoff zur Implantation im menschlichen oder tierischen Körper |
US6630153B2 (en) * | 2001-02-23 | 2003-10-07 | Smith & Nephew, Inc. | Manufacture of bone graft substitutes |
WO2001082773A2 (fr) * | 2000-04-28 | 2001-11-08 | The Regents Of The University Of California | Structures utiles dans le genie osseux et procedes |
US6852126B2 (en) | 2000-07-17 | 2005-02-08 | Nuvasive, Inc. | Stackable interlocking intervertebral support system |
MY133943A (en) | 2000-08-22 | 2007-11-30 | Synthes Gmbh | Bone replacement material |
US20020114795A1 (en) * | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
US7763769B2 (en) * | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
FR2830249B1 (fr) | 2001-10-03 | 2004-08-13 | Toulouse Inst Nat Polytech | Composition de ciment hydraulique a base de carbonates de calcium |
US6923814B1 (en) | 2001-10-30 | 2005-08-02 | Nuvasive, Inc. | System and methods for cervical spinal fusion |
US20050159820A1 (en) * | 2002-05-13 | 2005-07-21 | Hideki Yoshikawa | Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and artificial cartilage for transplantation |
US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
US7618423B1 (en) | 2002-06-15 | 2009-11-17 | Nuvasive, Inc. | System and method for performing spinal fusion |
DE10241572B4 (de) * | 2002-09-07 | 2007-02-08 | Werner Scholz | Stütz- oder Halteteil zum Einbringen in ein Knochenteil |
US7776049B1 (en) | 2002-10-02 | 2010-08-17 | Nuvasive, Inc. | Spinal implant inserter, implant, and method |
FR2850282B1 (fr) * | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
US7918876B2 (en) * | 2003-03-24 | 2011-04-05 | Theken Spine, Llc | Spinal implant adjustment device |
US20050020506A1 (en) * | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
US7918891B1 (en) | 2004-03-29 | 2011-04-05 | Nuvasive Inc. | Systems and methods for spinal fusion |
EP1604694A1 (fr) * | 2004-06-09 | 2005-12-14 | Scil Technology GmbH | Dispositif composé ayant de propriétes ostéoinductrices et ostéoconductrices |
WO2006109137A1 (fr) * | 2005-04-12 | 2006-10-19 | Sureshan Sivananthan | Regeneration tissulaire par endoculture |
EP1868539A2 (fr) * | 2005-04-15 | 2007-12-26 | Musculoskeletal Transplant Foundation | Reparation de disque vertebral |
US8623088B1 (en) | 2005-07-15 | 2014-01-07 | Nuvasive, Inc. | Spinal fusion implant and related methods |
WO2007016247A2 (fr) | 2005-07-28 | 2007-02-08 | Nuvasive, Inc. | Systeme de remplacement de disque entier et methodes associees |
WO2007048016A2 (fr) | 2005-10-20 | 2007-04-26 | Synthes (U.S.A.) | Dispositif de perfusion et procede |
US8506983B2 (en) * | 2006-05-01 | 2013-08-13 | Warsaw Orthopedic, Inc. | Bone filler material |
US7771741B2 (en) * | 2006-05-01 | 2010-08-10 | Warsaw Orthopedic, Inc | Demineralized bone matrix devices |
US7838022B2 (en) | 2006-05-01 | 2010-11-23 | Warsaw Orthopedic, Inc | Malleable implants containing demineralized bone matrix |
US20100209470A1 (en) * | 2006-05-01 | 2010-08-19 | Warsaw Orthopedic, Inc. An Indiana Corporation | Demineralized bone matrix devices |
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EP2211878B1 (fr) * | 2007-11-19 | 2015-04-15 | Ben Gurion University of the Negev Research And Development Authority | Effets du corail à médiation par le calcium et procédés d'utilisation correspondants |
US9056150B2 (en) | 2007-12-04 | 2015-06-16 | Warsaw Orthopedic, Inc. | Compositions for treating bone defects |
US8083796B1 (en) | 2008-02-29 | 2011-12-27 | Nuvasive, Inc. | Implants and methods for spinal fusion |
WO2009114535A2 (fr) * | 2008-03-10 | 2009-09-17 | Marfly 2, Lp | Composition de pâte osseuse |
US8840913B2 (en) | 2008-03-27 | 2014-09-23 | Warsaw Orthopedic, Inc. | Malleable multi-component implants and materials therefor |
HUE043110T2 (hu) * | 2008-11-20 | 2019-08-28 | Cartiheal 2009 Ltd | Szilárd formák szövetjavításhoz |
USD754346S1 (en) | 2009-03-02 | 2016-04-19 | Nuvasive, Inc. | Spinal fusion implant |
US9387090B2 (en) | 2009-03-12 | 2016-07-12 | Nuvasive, Inc. | Vertebral body replacement |
US9687357B2 (en) | 2009-03-12 | 2017-06-27 | Nuvasive, Inc. | Vertebral body replacement |
US8287597B1 (en) | 2009-04-16 | 2012-10-16 | Nuvasive, Inc. | Method and apparatus for performing spine surgery |
US9351845B1 (en) | 2009-04-16 | 2016-05-31 | Nuvasive, Inc. | Method and apparatus for performing spine surgery |
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USD731063S1 (en) | 2009-10-13 | 2015-06-02 | Nuvasive, Inc. | Spinal fusion implant |
CA2817584C (fr) | 2010-11-15 | 2018-01-02 | Zimmer Orthobiologics, Inc. | Substances de remplissage de vides osseux |
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FR2460657A1 (fr) * | 1979-07-12 | 1981-01-30 | Anvar | Implant biodegradable utilisable comme piece de prothese osseuse |
DE3433210C1 (de) * | 1984-09-10 | 1986-06-05 | Hans Dr.med. Dr.med.dent. 8000 München Scheicher | Mittel zur Fuellung von Knochen- und Zahndefekten,zum Knochenaufbau,fuer Knochenkontaktschichten und fuer Knochen- und Zahnwurzelersatz und Verwendung von Carbonatapatit fuer diesen Zweck |
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DE3542744C1 (de) * | 1985-12-03 | 1987-05-27 | Ewers Rolf | Poroeses Hydroxylapatit-Material |
AU3046289A (en) * | 1988-01-26 | 1989-08-25 | Thierry Rainier Besins | System for forming subperiostal deposits for facial restoration |
DK505588D0 (da) * | 1988-02-26 | 1988-09-09 | Jesper Hamburger | Middel og anvendelse af samme |
FR2637502A1 (fr) * | 1988-10-12 | 1990-04-13 | Duroselle Patrick | Materiau de xenogreffe osseuse et procede d'obtention |
US5264214A (en) * | 1988-11-21 | 1993-11-23 | Collagen Corporation | Composition for bone repair |
US4976736A (en) * | 1989-04-28 | 1990-12-11 | Interpore International | Coated biomaterials and methods for making same |
US5071655A (en) * | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
-
1993
- 1993-11-17 FR FR9313740A patent/FR2706768B1/fr not_active Expired - Fee Related
-
1994
- 1994-05-11 CA CA002139864A patent/CA2139864C/fr not_active Expired - Fee Related
- 1994-05-11 DE DE69425358T patent/DE69425358T2/de not_active Expired - Lifetime
- 1994-05-11 PT PT94916275T patent/PT650374E/pt unknown
- 1994-05-11 WO PCT/FR1994/000565 patent/WO1994026322A1/fr active IP Right Grant
- 1994-05-11 US US08/360,801 patent/US5711957A/en not_active Expired - Lifetime
- 1994-05-11 EP EP94916275A patent/EP0650374B1/fr not_active Expired - Lifetime
- 1994-05-11 ES ES94916275T patent/ES2150492T3/es not_active Expired - Lifetime
- 1994-05-11 JP JP6525071A patent/JP2957281B2/ja not_active Expired - Fee Related
- 1994-05-11 AU AU67887/94A patent/AU676056B2/en not_active Ceased
- 1994-05-11 DK DK94916275T patent/DK0650374T3/da active
- 1994-05-11 AT AT94916275T patent/ATE194922T1/de active
-
2000
- 2000-10-23 GR GR20000402357T patent/GR3034667T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2139864C (fr) | 2003-07-15 |
JPH08503157A (ja) | 1996-04-09 |
FR2706768A1 (fr) | 1994-12-30 |
ES2150492T3 (es) | 2000-12-01 |
WO1994026322A1 (fr) | 1994-11-24 |
AU6788794A (en) | 1994-12-12 |
DK0650374T3 (da) | 2000-11-06 |
FR2706768B1 (fr) | 1995-12-01 |
EP0650374A1 (fr) | 1995-05-03 |
PT650374E (pt) | 2000-12-29 |
EP0650374B1 (fr) | 2000-07-26 |
DE69425358T2 (de) | 2001-03-29 |
JP2957281B2 (ja) | 1999-10-04 |
DE69425358D1 (de) | 2000-08-31 |
ATE194922T1 (de) | 2000-08-15 |
US5711957A (en) | 1998-01-27 |
GR3034667T3 (en) | 2001-01-31 |
AU676056B2 (en) | 1997-02-27 |
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EEER | Examination request | ||
MKLA | Lapsed |
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