CA2139312A1 - Ablation catheter positioning system - Google Patents
Ablation catheter positioning systemInfo
- Publication number
- CA2139312A1 CA2139312A1 CA002139312A CA2139312A CA2139312A1 CA 2139312 A1 CA2139312 A1 CA 2139312A1 CA 002139312 A CA002139312 A CA 002139312A CA 2139312 A CA2139312 A CA 2139312A CA 2139312 A1 CA2139312 A1 CA 2139312A1
- Authority
- CA
- Canada
- Prior art keywords
- electrode
- catheter
- signal
- electrodes
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
- A61B5/287—Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1402—Probes for open surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00059—Material properties
- A61B2018/00071—Electrical conductivity
- A61B2018/00083—Electrical conductivity low, i.e. electrically insulating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/0016—Energy applicators arranged in a two- or three dimensional array
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00839—Bioelectrical parameters, e.g. ECG, EEG
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00875—Resistance or impedance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B2018/1246—Generators therefor characterised by the output polarity
- A61B2018/126—Generators therefor characterised by the output polarity bipolar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B2018/1286—Generators therefor having a specific transformer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1467—Probes or electrodes therefor using more than two electrodes on a single probe
Abstract
A multi-electrode cardiac catheter (10) has pairs of electrodes (13) connected to sensing circuitry (31, 32, 40) to produce a differential signal. The sensing output is sharply defined and self normalizing. Preferably, a catheter ablation tip electrode (12) is an electrode of one pair, and the differential signal becomes non-zero when the tip contacts surrounding tissue. The shape of the differential signal provides information on the degree of electrode contact, as well as on the amount of locally-sensed tissue im-pedance change. The signal may be used as a trigger enable signal for a cardiac ablation catheter (10), and the applied level of RF
power may be controlled based on the indicated degree of electrode contact and value of tissue impedance.
power may be controlled based on the indicated degree of electrode contact and value of tissue impedance.
Description
~3~3~
-I -ABLATION CATHETER POSITIONING SYSTEM
The present invention relates to electrode-bearing catheters, and more 5 particularly to catheters of the type which are inserted along a blood vessel in order to position its electrodes in the region of a patient's heart. The electrodes may be used for sensing cardiac eleckical signals, applying electrical stimulation for diagnostic testing or the like, or applying treatment signals, such as tissue ablation signals. The catheter may include other structures, such as a lumen and a 10 delivery system, for applying light, thermal energy or chemical agents, or a sampling system for sampling tissue, forming images of tissue or withdrawing a specimen of the surrounding fluid.
To position such an electrode-bearing catheter at a desired site within 15 the patient's body, one or more catheter insertion and radiographic vis~l~li7~tion steps are usually required in the course of bringing the catheter to its generaltarget area. - Once the catheter has been placed in position, further control and interaction by the surgeon is generally required to assure that the catheter is precisely positioned and properly oriented to p-,.rO~ its intended functions.
For example, when the catheter is an RF tissue ablation or coagulation treatment catheter, it may be necess~ry to perform various prelimin~ry electrical measurements or mapping operations to assure that the power electrodehas moved into contact with a specific tissue region that is to be treated, such as a 2s cardiac lesion, that is initi~tin~ arrhythmias.
Among the prior art known to applicant, one cardiac catheter of this type is configured as a special purpose mapping catheter, and utilizes a multi-electrode structure to generate characteristic tissue impedance responses at 30 different tissue sites, from which the relative position of the catheter can be determined. Specifically, U.S. Patent 4,911,174 shows such an electrode structure wherein the impedance is measured by successive pairs of electrodes to detect when an electrode has advanced beyond a blood~tissue interface. An abrupt shift in phase of the detected impedance is noted at the electrode positioned by the 3s interface. The device of that patent appears to be intended for the very specific purpose of determining the size of a patient's ventrical, or more precisely, positioning a catheter having a plurality of surface ring electrodes in the ventrical in such a way that the relative locations of the electrodes are known and it ~1393~
wo 94/00050 Pcr/uss3/05782 becomes possible to map an impedance distribution from which ventricle volume is derived.
Other forms of catheter impedance measurement are known, s generally involving the measurement of loc~li7ed or whole body impedance pathsfor the purpose of setting or controlling the level of power delivery of an RF
coagulation electrode during electrosurgery. To applicant's knowledge such systems have no application to catheter positioning.
It is therefore desirable to develop more accurate ways of positioning or orienting a catheter by the use of electrical signals detecte~l at its electrodes.
Snmm~ry of the Invention It is an object of the present invention to provide a positioning system for a cardiac ablation catheter.
It is another object of the present invention to provide a catheter system useful for llla~ing and ablation of tissue.
It is another object of the invention to provide an improved system for monitoring electrical activity of cardiac tissue.
These and other desirable objects are achieved in accordance with the 25 present invention by providing a multi-electrode catheter having pairs of electrodes, stimulating at least one pair of the electrodes to provide a sensingsignal responsive to regional tissue variations, and combining two or more sensing signals. Preferably the combined sensing signal is a dirr~lelllial signal developed from several sets of electrodes such that the magnitude of the combined signal is 30 null except when two sets of electrodes reside in or near regions of dirr~.h~g tissue type. The circuit connection is such that the signal vanishes when the electrodes all reside in similar tissue environments. By forming a dirr~elllial signal frommultiple sets of electrodes in this way, the invention elimin~tec the thresholding, norm~li7ing or averaging and other complex signal processing operations 3s formerly necessary to obtain a meaningful impedance measurement. Furthermore,by selection of particular ones of the catheter electrodes for polling, the precise orientation or position of the catheter is determined.
2139;31~
wo 94/oooso Pcr/uss3/o5782 _ --3 In a preferred embodiment, the catheter is a cardiac ablation catheter having a tip electrode for applying ablation energy to a tissue site. Tissue impedance is measured by applying probe signals between the tip and a downstream electrode, sensing the return current through two or more s intermediate ring eleckodes located below the tip, and combining the sensed return current to define a differential signal. So long as each electrode resides in blood, the inter-electrode impedance path characteristics of each electrode pair are similar, and after being dirrelclllially combined with a gain factor to correct for electrode geometry, they yield a null signal. Thus, the electrode is self-zeroing lO without calibration in an external saline cell. However, when the catheter resides in a blood vessel and the tip electrode contacts tissue, the differential signal rises sha~ply. Similarly, should a proximal electrode contact the vessel wall, a similarly discernible signal will occur, but of reversed polarity. The differential outputsignal thus provides a dependable indication that the catheter has assumed an lS effective position for applying ele-iLlosulgical power.
Rrief nescription of t~e nrawir~
The invention will be understood from the description of illustrative 20 embodiments below, taken together with the drawings, wherein Figure l is a perspective view of a multi-electrode catheter for the practice of the present invention;
Z1~9312 WO 94/00050 ~ ~ PCI/US93/05782 Figure 2 and 3 show catheter signal coupling arrangement for the practice of the present invention;
Figure 2A shows a detail of electrode signal sampling circuitry;
Figure 4 shows a representative catheter signal traces; and Figure 5 shows catheter signal processing elements.
10 Det~iled T)escription of the Inve~tion A multi-electrode lll~yying and ablation catheter 10 is shown in Figure 1, and is characterized by an elongated insulating body 8 having a rounded tip electrode 12 mounted at its tip, and a plurality of axially-spaced ring electrodes S 13a, 13b ... mounted along its surface. Each ofthe ring electrodes has dimensions and an exposed surface area Ar identical to the others, and they are preferably equi-spaced along the body 8. The tip electrode 12, which may also take other forms, such as a split wire, or bipolar electrode, has a somewhat larger area At.
Catheter 10 is mounted at the end of a flexible but axially incompressible tube 20 20 which is used for manipulating and inserting the catheter along a vessel, and a plurality of electrode signal leads 30 extend from the various electrodes, through the catheter body 8 and tube 20 to a control circuit located outside the body.
Leads 30 allow each electrode to be separately connected to the control circuit or they may be connected to sense the propagation of the tip electrode signal.
2s For example, tip electrode 12 may be connected to a relatively strong source of RF power which is adjustably controlled to perform tissue ablation, or is operated at a lower level to provide a monitoring signal for determining tissue impedance measurements. Ring electrodes 13a, 13b ... are connected to sensing 30 and signal processing circuity for sensing muscle discharge pot~nti~l~ and mapping the locations of cardiac lesions or arrhythmia-generating nodes.
In a conventional mapping protocol, the catheter may be slowly advanced along an intracardial vessel, and local arrhythmias stim~ te~ by a pulse 3s signal emitted at the tip electrode may be ~etectç~l and mapped by an analysis of the signal as detected at each of the plurality of ring electrodes. Once a tissue site responsible for initiating an arrhythmia is mapped, the catheter is then repositioned to coagulate the arrhythmia site by placing the tip in contact with the 21393~Z
W O 94/00050 PC~r/US93/05782 site and applying an RF signal of effective tissue coagulating power thereto.
In using a multi-electrode mapping probe in this manner to first identify and then coagulate unhealthy tissue, it is necessary that the tip electrode s 12 be contacting, or at least in very close proximity to the target tissue site. This is because the region of effective RF power delivery drops off sharply away fromthe immediate surface of the treatment electrode. Moving tip 12 even a few millimeters away from a tissue site can reduce the applied energy to an ineffective level, or can cause coagulation of blood to occur in the vessel rather than ablation o of adjacent tissue.
In accordance with the present invention, the relative position of a probe is ~eterrnined with respect to surrounding tissue by applying a test signal, for example, a continuous-wave, low power, AC signal, between a pair of outer electrodes arrayed along the catheter, and pairing each outer electrode with an inner electrode to develop a sensing signal characteristic of impedance for the tissue between the electrodes. By "outer" is meant an electrode which lies axially at one extreme of a set of the electrodes. Thus, in Figure 2, showing the tip electrode and successive first, second and third ring electrodes, the tip electrode 20 and the third ring electrode are the outer electrodes of the set, and an AC pulse signal is applied between these two electrodes to establish an impedance chain or bridge extending through the tissue spanning all of the intermediate electrodes.Thus, the tissue acts as an impedance dividing bridge, allowing local impedance to be sensed between any pair of intermediate electrodes.
As shown in Figure 2, signal amplifiers 31, 32 are e~ach connected to one pair of electrodes to develop a signal that is essentially proportional to the product of the electrode area times a function of the impedance of tissue lying between the two electrodes of the pair. A no~n~li7ing gain 9 is applied to one 30 amplifier, preferably to amplifier 32, to correct by a scale factor the contribution of the larger (tip) electrode. This gain is a constant that, for a given general probe size and shape, depends only on the relative area and spacing of electrode 12, and may be readily set, for example, when the electrodes are immersed in a sample saline solution. The gain factor norm~li7es the amplifier outputs, so that when 35 both pairs of electrodes are immersed in the same tissue, e.g., blood, the outputs of the respective amplifiers will be equal. The outputs of both amplifiers 31, 32 are applied as the inputs to a final or second stage arnplifier 40. Amplifier 40 produces an output signal proportional to the difference in the signal potentials Z1~931~ ` `
W O 94/00050 PC~r/US93/05782 -6-appearing at its input tçrmin~ , so that it has a net output only when the outputs of amplifiers 31, 32 differ, i.e., when different tissue types are positioned near to the two different electrode pairs, producing distinctly different sets of impedance paths.
Preferably, as shown in Figure 2A, the a~pal~allls further comprises a multiplex switch 42a, 42b which operates, either with manual selection by a user, or preferably as shown under program control by a state selector 43 to selectively connect the dirr~ lial impedance sensing circuil,y to different pairs ofthe o catheter electrodes 1 3i, 1 3k. By coupling the state of the multiplex switch 42a, 42b to a suitable display, the system indicates detection, for example, of tissue impedance changes that occur within a region spanned by an ~I,iLI~u y one of thesensing electrode pairs, rather than simply the frontmost pair as described above for the sensing electrode configuration of Figures 1 and 2.
Switching unit 42a, 42b may also be controlled to vary the spatial resolution of the impedance detection Cil~iuill~y, by selecting the sensing signals across pairs of electrodes that are separated from each other by one or more electrodes, or the signals from two pairs of electrodes wherein the electrodes of 20 one pair are spaced from the electrodes of the other pair by one or more intervening ring electrodes 13.
An alternative construction (not illustrated) dispenses with the switching unit 42a, 42b, and directly attaches each pair of adjacent electrodes to 2s its own amplifier, with each adjacent pair of amplifiers having its outputs fixedly attached to a second stage amplifier. In that embodiment, an output switching unit 42c may be employed to sample the outputs of either the first stage or the second stage amplifier, rather than to switch the electrodes between inputs of the first stage amplifiers. This alternative construction, while lacking the flexibility to 30 monitor an impedance path extending between widely-separated ring electrodes, may quickly identify the precise region of tissue change.
Figure 3 shows an ~ltçrn~tive circuit for the practice of the present invention. The probe 10 is illustrated schematically, with only the tip and three 35 ring electrodes shown. The ring electrodes may, for example, be the first, second and third rings, or first, third and fourth, or any three rings spaced in order along the catheter. They are therefore simply labeled A, B, C and D to indicate their order of appearance along the catheter axis, for clarity of discussion. An RF
Z13~;~2 wo 94/00050 Pcr/uss3/05782 generator 52 is transformer coupled to the probe across the outer electrodes, toapply a biologically safe probe signal at a level of approximately two volts RMS.
In this embodiment, a first pair of electrodes, A and B, are connected to a current transformer winding S1, and a second pair of electrodes, C and D, are connected s to a separate winding S2 in the opposite sense. A common primary winding or series connected pair of windings, denoted P in Figure 3, is magnetically coupled via transformer core C to the electrode sensing windings S 1 and S2 so that the winding P develops a signal which is essentially a phase-delayed multiple of thedifference in the electrical signal sensed by the two electrode pairs. The sensing o windings Si for all adjacent ring electrodes 13i, 13i+l, are all similar, but the sensing winding St attached to tip electrode 12 prefeldbly is wound such that the ratio of the number of turns in the winding St to those in winding Si is inversely proportional to the effective areas of the respective electrode pairs, times a distance factor reflecting the geometry and spacing of the irregularly spaced tip electrode from the ring electrode with which it is paired. The winding ratio is selected so that the sum of the sense and anti-sense impedance signals in coils St, Si is nominally zero when both pairs of electrodes are fully immersed in blood.
As shown, transformer winding P is connected to a 20 discrimination/control circuit T, which may, for example, integrate the m~gnit~lde of the signal detected across winding P and put out a trigger enable signal whenthe integrated value exceeds a predetçrmined threshold indicative of electrode tissue contact. Alternatively, circuit T may put out a norm~li7ed sense impedance value, which may serve as a basis for determining the relative disposition of the 25 catheter or the type of tissue which surrounds or contacts the catheter. It will be understood that the circuit of Figure 2A may also be employed in a transformer coupled circuit of this type. In that case, it is preferable to have the multiplex switching units selectively connect the catheter electrode pairs to the kansformer sensing coils in an arrangement whereby plural different electrodes are selectively 30 connected to a single pair of win~ing~ of one coupling transformer.
Figure 4 shows typical signal traces of a signal when all of the sampled electrodes are disposed in a homogeneous medium, as detected between electrodes A, B (trace A of the Figure), and electrodes C, D (trace B of the 3s Figure). Trace C shows the signal of trace A norm~li7ed by a constant scale factor to correct for the different area and spacing of tip electrode A, and trace D
shows the combined signal, as appearing, for example across the winding P of thetransformer in Figure 3 or the output stage amplifier 40 of Figure 2.
WO 94tO0050 -8- PCr/US93/05782 Traces E-H of Figure 4 show the signals corresponding to those of traces A-D, respectively, when the catheter has moved to a position such that the body of the catheter resides in blood, but tip electrode 12 (Figure 1 ) has beens brought into close proximity or contact with a vessel wall or heart muscle tissue.
As illustrated, the combined output signal (trace D or H) becomes non-null and develops a discernible peak, upon contact of the tip with heterogeneous tissue.
This peak is more or less well-defined, depending upon the degree of proximity to, or area of contact between, electrode 12 and the surrounding tissue structures.
It will be understood that the non-zero differential sensing peak need not be a positive-valued signal as shown, but may include negative dips or have some other shape or polarity, caused by phase inversion or the like which occursas a consequence of the locally varying tissue structures. Further, it will be understood that the sensed signals need not be fully represçnt~tive of the tissue impedance function, but rather are sensed signals from which impedance is derivable. For example, when impedance itself is to be monitored in order to determine a substantive physical property of the surrounding tissue, e.g., the type of tissue or its degree of coagulation, the in~t~nt~neous voltage and current of an 20 electrode pair may be sampled, processed and colll,ualed to an RF probe signal that has been applied by signal generator 50 (Figure 2), to provide an actual impedance function. In general, however, the benefits of the invention are achieved in simply detecting the magnitude of a well-defined difference signal, lines F-H, when it is only desired, for example, to confirm that tissue contact by 25 the probe tip has occurred.
Figure 5 is a sch~m~tic block diagram for the operation of a catheter positioning system 100 for controllably positioning an ablation catheter in the cardiac region. As shown in Figure 5, a processor 120 is interconnected with the30 sensing and tre~tment electrodes 12, 13i of catheter 10 via a switching unit 130 comparable to switching unit 42a, 42b of Figure 2A, connected to a signal conditioning circuit 135. Processor 120 controls the switching unit to select spaced electrodes, plGfel~bly two pairs as described above, selected from three or more electrodes, for connection to the signal conditioning circuit, and then 35 receives and evaluates the output of the signal conditioning circuit 135 to detect either the presence of a tissue impedance change at a particular selected electrode, or the value of the local tissue impedance. Signal conditioning circuit 135 may include an arrangement of dirr~relltial amplifiers as described above, and 2 1~3~1 Z
wo 94/ooosO Pcr/uss3/05782 ~ 9 indicated schematically in the Figure. Alternatively, circuit 135 may include circuit elements only for filtering and amplifying the inter-electrode signals. In that case, the outputs of circuit 135 may be digitized and the microprocessor may digitally combine the output signals to obtain a dirr~lential impedance function.
s In a variation as described above, an alternative embodiment may have its electrodes fixedly connected to an array of dirrelential signal amplifiers.
In that embodiment, the outputs of the signal conditioning amplifiers are switchably sampled via an n:4 switching unit under the control of the processor o 120 and similar to unit 130, but located between the signal conditioner 135 and processor 120.
In either case, processor 120 correlates the ~etected electrode signals with particular ones of the electrodes, preferably by polling them in an orderedsequence, and drives and synchronizes a display 140 to represent the detected tissue characteristics. Display 140 may, for example, depict the probe with a variable marker - such as a LED bar display or a plurality of discrete LEDs mounted on a graphic representation of the catheter. The LEDS are ~ct~1~ted by the processor to display the processed information. Specifically, display 140 may show the site along the probe at which the dirr~rel-lial impedance change has been detecte~l by illllmin~ting a LED at that location; or may show which electrodes are in contact with tissue by illllmin~ting a special colored light at the corresponding electrode location. It may also show information such as displaying the relative portion of the probe which has been inserted into the heart.
2s This may be done by selectively ill~lmin~ting LED markers along that portion of the displayed image of the probe colle~onding to one or more detected impedances or signal conditions which indicate that a longit~-din~lly extending region of the probe body has passed a heart valve, or resides inside a closed tissue structure.
Processor i20, in addition to executing one or more logical programs to determine and display probe disposition corresponding to the detected dirr~.ell~ial electrode signals, preferably is part of a cardiac ablation or electrosurgery control s~ ~Lem. In that case the processor also provides a signal along line 142 to the RF power control unit 45 of the system, for controlling the level of power applied to the probe tip. Some forms of coagulation or ablation power control are conventional, for example, programmed control to apply a sufficient power level, based on sensed whole body tissue impedance, to destroy WO 94/00050 Z139~Z PCI /US93/05782 tissue locally at the tip electrode without causing damage to non-involved tissue.
In accordance with the coagulation control aspect of the present invention, the processor detects the electrode disposition, and provides a signal to the power control unit 45 to adjust the level of localized power based further on the area of s contact of the tip electrode, which is derived, by microprocessor 120, from the magnitude ofthe dirre.~.llial impedance signal. Thus, for example, when the tip achieves only partial contact, as indicated by a ~etecte~l charge curve that has a sharply defined shape but still has a relatively high impedance value, the ablation power may be reduced from the conventionally-selected level, to a lower level l0 that limits the amount of ablation energy applied to the contact point. Thus, rather than allowing coagulation to extend into the bloodstream as could occur if the power were delivered based on the as~u~ lion of full electrode contact to the vessel wall tissue, a smaller pulse of energy is applied to affect only the smaller area of tissue actually cont~cting the electrode.
Other variations and modifications adapting the dirrelential signal sensing electrodes and system of the present invention to known cardiac mapping or ablation systems and probes will occur to those skilled in the art, and all such variations and modifications are considered to be within the spirit and scope of the 20 invention to which patent rights are sought, as set forth in the claims appended hereto.
-I -ABLATION CATHETER POSITIONING SYSTEM
The present invention relates to electrode-bearing catheters, and more 5 particularly to catheters of the type which are inserted along a blood vessel in order to position its electrodes in the region of a patient's heart. The electrodes may be used for sensing cardiac eleckical signals, applying electrical stimulation for diagnostic testing or the like, or applying treatment signals, such as tissue ablation signals. The catheter may include other structures, such as a lumen and a 10 delivery system, for applying light, thermal energy or chemical agents, or a sampling system for sampling tissue, forming images of tissue or withdrawing a specimen of the surrounding fluid.
To position such an electrode-bearing catheter at a desired site within 15 the patient's body, one or more catheter insertion and radiographic vis~l~li7~tion steps are usually required in the course of bringing the catheter to its generaltarget area. - Once the catheter has been placed in position, further control and interaction by the surgeon is generally required to assure that the catheter is precisely positioned and properly oriented to p-,.rO~ its intended functions.
For example, when the catheter is an RF tissue ablation or coagulation treatment catheter, it may be necess~ry to perform various prelimin~ry electrical measurements or mapping operations to assure that the power electrodehas moved into contact with a specific tissue region that is to be treated, such as a 2s cardiac lesion, that is initi~tin~ arrhythmias.
Among the prior art known to applicant, one cardiac catheter of this type is configured as a special purpose mapping catheter, and utilizes a multi-electrode structure to generate characteristic tissue impedance responses at 30 different tissue sites, from which the relative position of the catheter can be determined. Specifically, U.S. Patent 4,911,174 shows such an electrode structure wherein the impedance is measured by successive pairs of electrodes to detect when an electrode has advanced beyond a blood~tissue interface. An abrupt shift in phase of the detected impedance is noted at the electrode positioned by the 3s interface. The device of that patent appears to be intended for the very specific purpose of determining the size of a patient's ventrical, or more precisely, positioning a catheter having a plurality of surface ring electrodes in the ventrical in such a way that the relative locations of the electrodes are known and it ~1393~
wo 94/00050 Pcr/uss3/05782 becomes possible to map an impedance distribution from which ventricle volume is derived.
Other forms of catheter impedance measurement are known, s generally involving the measurement of loc~li7ed or whole body impedance pathsfor the purpose of setting or controlling the level of power delivery of an RF
coagulation electrode during electrosurgery. To applicant's knowledge such systems have no application to catheter positioning.
It is therefore desirable to develop more accurate ways of positioning or orienting a catheter by the use of electrical signals detecte~l at its electrodes.
Snmm~ry of the Invention It is an object of the present invention to provide a positioning system for a cardiac ablation catheter.
It is another object of the present invention to provide a catheter system useful for llla~ing and ablation of tissue.
It is another object of the invention to provide an improved system for monitoring electrical activity of cardiac tissue.
These and other desirable objects are achieved in accordance with the 25 present invention by providing a multi-electrode catheter having pairs of electrodes, stimulating at least one pair of the electrodes to provide a sensingsignal responsive to regional tissue variations, and combining two or more sensing signals. Preferably the combined sensing signal is a dirr~lelllial signal developed from several sets of electrodes such that the magnitude of the combined signal is 30 null except when two sets of electrodes reside in or near regions of dirr~.h~g tissue type. The circuit connection is such that the signal vanishes when the electrodes all reside in similar tissue environments. By forming a dirr~elllial signal frommultiple sets of electrodes in this way, the invention elimin~tec the thresholding, norm~li7ing or averaging and other complex signal processing operations 3s formerly necessary to obtain a meaningful impedance measurement. Furthermore,by selection of particular ones of the catheter electrodes for polling, the precise orientation or position of the catheter is determined.
2139;31~
wo 94/oooso Pcr/uss3/o5782 _ --3 In a preferred embodiment, the catheter is a cardiac ablation catheter having a tip electrode for applying ablation energy to a tissue site. Tissue impedance is measured by applying probe signals between the tip and a downstream electrode, sensing the return current through two or more s intermediate ring eleckodes located below the tip, and combining the sensed return current to define a differential signal. So long as each electrode resides in blood, the inter-electrode impedance path characteristics of each electrode pair are similar, and after being dirrelclllially combined with a gain factor to correct for electrode geometry, they yield a null signal. Thus, the electrode is self-zeroing lO without calibration in an external saline cell. However, when the catheter resides in a blood vessel and the tip electrode contacts tissue, the differential signal rises sha~ply. Similarly, should a proximal electrode contact the vessel wall, a similarly discernible signal will occur, but of reversed polarity. The differential outputsignal thus provides a dependable indication that the catheter has assumed an lS effective position for applying ele-iLlosulgical power.
Rrief nescription of t~e nrawir~
The invention will be understood from the description of illustrative 20 embodiments below, taken together with the drawings, wherein Figure l is a perspective view of a multi-electrode catheter for the practice of the present invention;
Z1~9312 WO 94/00050 ~ ~ PCI/US93/05782 Figure 2 and 3 show catheter signal coupling arrangement for the practice of the present invention;
Figure 2A shows a detail of electrode signal sampling circuitry;
Figure 4 shows a representative catheter signal traces; and Figure 5 shows catheter signal processing elements.
10 Det~iled T)escription of the Inve~tion A multi-electrode lll~yying and ablation catheter 10 is shown in Figure 1, and is characterized by an elongated insulating body 8 having a rounded tip electrode 12 mounted at its tip, and a plurality of axially-spaced ring electrodes S 13a, 13b ... mounted along its surface. Each ofthe ring electrodes has dimensions and an exposed surface area Ar identical to the others, and they are preferably equi-spaced along the body 8. The tip electrode 12, which may also take other forms, such as a split wire, or bipolar electrode, has a somewhat larger area At.
Catheter 10 is mounted at the end of a flexible but axially incompressible tube 20 20 which is used for manipulating and inserting the catheter along a vessel, and a plurality of electrode signal leads 30 extend from the various electrodes, through the catheter body 8 and tube 20 to a control circuit located outside the body.
Leads 30 allow each electrode to be separately connected to the control circuit or they may be connected to sense the propagation of the tip electrode signal.
2s For example, tip electrode 12 may be connected to a relatively strong source of RF power which is adjustably controlled to perform tissue ablation, or is operated at a lower level to provide a monitoring signal for determining tissue impedance measurements. Ring electrodes 13a, 13b ... are connected to sensing 30 and signal processing circuity for sensing muscle discharge pot~nti~l~ and mapping the locations of cardiac lesions or arrhythmia-generating nodes.
In a conventional mapping protocol, the catheter may be slowly advanced along an intracardial vessel, and local arrhythmias stim~ te~ by a pulse 3s signal emitted at the tip electrode may be ~etectç~l and mapped by an analysis of the signal as detected at each of the plurality of ring electrodes. Once a tissue site responsible for initiating an arrhythmia is mapped, the catheter is then repositioned to coagulate the arrhythmia site by placing the tip in contact with the 21393~Z
W O 94/00050 PC~r/US93/05782 site and applying an RF signal of effective tissue coagulating power thereto.
In using a multi-electrode mapping probe in this manner to first identify and then coagulate unhealthy tissue, it is necessary that the tip electrode s 12 be contacting, or at least in very close proximity to the target tissue site. This is because the region of effective RF power delivery drops off sharply away fromthe immediate surface of the treatment electrode. Moving tip 12 even a few millimeters away from a tissue site can reduce the applied energy to an ineffective level, or can cause coagulation of blood to occur in the vessel rather than ablation o of adjacent tissue.
In accordance with the present invention, the relative position of a probe is ~eterrnined with respect to surrounding tissue by applying a test signal, for example, a continuous-wave, low power, AC signal, between a pair of outer electrodes arrayed along the catheter, and pairing each outer electrode with an inner electrode to develop a sensing signal characteristic of impedance for the tissue between the electrodes. By "outer" is meant an electrode which lies axially at one extreme of a set of the electrodes. Thus, in Figure 2, showing the tip electrode and successive first, second and third ring electrodes, the tip electrode 20 and the third ring electrode are the outer electrodes of the set, and an AC pulse signal is applied between these two electrodes to establish an impedance chain or bridge extending through the tissue spanning all of the intermediate electrodes.Thus, the tissue acts as an impedance dividing bridge, allowing local impedance to be sensed between any pair of intermediate electrodes.
As shown in Figure 2, signal amplifiers 31, 32 are e~ach connected to one pair of electrodes to develop a signal that is essentially proportional to the product of the electrode area times a function of the impedance of tissue lying between the two electrodes of the pair. A no~n~li7ing gain 9 is applied to one 30 amplifier, preferably to amplifier 32, to correct by a scale factor the contribution of the larger (tip) electrode. This gain is a constant that, for a given general probe size and shape, depends only on the relative area and spacing of electrode 12, and may be readily set, for example, when the electrodes are immersed in a sample saline solution. The gain factor norm~li7es the amplifier outputs, so that when 35 both pairs of electrodes are immersed in the same tissue, e.g., blood, the outputs of the respective amplifiers will be equal. The outputs of both amplifiers 31, 32 are applied as the inputs to a final or second stage arnplifier 40. Amplifier 40 produces an output signal proportional to the difference in the signal potentials Z1~931~ ` `
W O 94/00050 PC~r/US93/05782 -6-appearing at its input tçrmin~ , so that it has a net output only when the outputs of amplifiers 31, 32 differ, i.e., when different tissue types are positioned near to the two different electrode pairs, producing distinctly different sets of impedance paths.
Preferably, as shown in Figure 2A, the a~pal~allls further comprises a multiplex switch 42a, 42b which operates, either with manual selection by a user, or preferably as shown under program control by a state selector 43 to selectively connect the dirr~ lial impedance sensing circuil,y to different pairs ofthe o catheter electrodes 1 3i, 1 3k. By coupling the state of the multiplex switch 42a, 42b to a suitable display, the system indicates detection, for example, of tissue impedance changes that occur within a region spanned by an ~I,iLI~u y one of thesensing electrode pairs, rather than simply the frontmost pair as described above for the sensing electrode configuration of Figures 1 and 2.
Switching unit 42a, 42b may also be controlled to vary the spatial resolution of the impedance detection Cil~iuill~y, by selecting the sensing signals across pairs of electrodes that are separated from each other by one or more electrodes, or the signals from two pairs of electrodes wherein the electrodes of 20 one pair are spaced from the electrodes of the other pair by one or more intervening ring electrodes 13.
An alternative construction (not illustrated) dispenses with the switching unit 42a, 42b, and directly attaches each pair of adjacent electrodes to 2s its own amplifier, with each adjacent pair of amplifiers having its outputs fixedly attached to a second stage amplifier. In that embodiment, an output switching unit 42c may be employed to sample the outputs of either the first stage or the second stage amplifier, rather than to switch the electrodes between inputs of the first stage amplifiers. This alternative construction, while lacking the flexibility to 30 monitor an impedance path extending between widely-separated ring electrodes, may quickly identify the precise region of tissue change.
Figure 3 shows an ~ltçrn~tive circuit for the practice of the present invention. The probe 10 is illustrated schematically, with only the tip and three 35 ring electrodes shown. The ring electrodes may, for example, be the first, second and third rings, or first, third and fourth, or any three rings spaced in order along the catheter. They are therefore simply labeled A, B, C and D to indicate their order of appearance along the catheter axis, for clarity of discussion. An RF
Z13~;~2 wo 94/00050 Pcr/uss3/05782 generator 52 is transformer coupled to the probe across the outer electrodes, toapply a biologically safe probe signal at a level of approximately two volts RMS.
In this embodiment, a first pair of electrodes, A and B, are connected to a current transformer winding S1, and a second pair of electrodes, C and D, are connected s to a separate winding S2 in the opposite sense. A common primary winding or series connected pair of windings, denoted P in Figure 3, is magnetically coupled via transformer core C to the electrode sensing windings S 1 and S2 so that the winding P develops a signal which is essentially a phase-delayed multiple of thedifference in the electrical signal sensed by the two electrode pairs. The sensing o windings Si for all adjacent ring electrodes 13i, 13i+l, are all similar, but the sensing winding St attached to tip electrode 12 prefeldbly is wound such that the ratio of the number of turns in the winding St to those in winding Si is inversely proportional to the effective areas of the respective electrode pairs, times a distance factor reflecting the geometry and spacing of the irregularly spaced tip electrode from the ring electrode with which it is paired. The winding ratio is selected so that the sum of the sense and anti-sense impedance signals in coils St, Si is nominally zero when both pairs of electrodes are fully immersed in blood.
As shown, transformer winding P is connected to a 20 discrimination/control circuit T, which may, for example, integrate the m~gnit~lde of the signal detected across winding P and put out a trigger enable signal whenthe integrated value exceeds a predetçrmined threshold indicative of electrode tissue contact. Alternatively, circuit T may put out a norm~li7ed sense impedance value, which may serve as a basis for determining the relative disposition of the 25 catheter or the type of tissue which surrounds or contacts the catheter. It will be understood that the circuit of Figure 2A may also be employed in a transformer coupled circuit of this type. In that case, it is preferable to have the multiplex switching units selectively connect the catheter electrode pairs to the kansformer sensing coils in an arrangement whereby plural different electrodes are selectively 30 connected to a single pair of win~ing~ of one coupling transformer.
Figure 4 shows typical signal traces of a signal when all of the sampled electrodes are disposed in a homogeneous medium, as detected between electrodes A, B (trace A of the Figure), and electrodes C, D (trace B of the 3s Figure). Trace C shows the signal of trace A norm~li7ed by a constant scale factor to correct for the different area and spacing of tip electrode A, and trace D
shows the combined signal, as appearing, for example across the winding P of thetransformer in Figure 3 or the output stage amplifier 40 of Figure 2.
WO 94tO0050 -8- PCr/US93/05782 Traces E-H of Figure 4 show the signals corresponding to those of traces A-D, respectively, when the catheter has moved to a position such that the body of the catheter resides in blood, but tip electrode 12 (Figure 1 ) has beens brought into close proximity or contact with a vessel wall or heart muscle tissue.
As illustrated, the combined output signal (trace D or H) becomes non-null and develops a discernible peak, upon contact of the tip with heterogeneous tissue.
This peak is more or less well-defined, depending upon the degree of proximity to, or area of contact between, electrode 12 and the surrounding tissue structures.
It will be understood that the non-zero differential sensing peak need not be a positive-valued signal as shown, but may include negative dips or have some other shape or polarity, caused by phase inversion or the like which occursas a consequence of the locally varying tissue structures. Further, it will be understood that the sensed signals need not be fully represçnt~tive of the tissue impedance function, but rather are sensed signals from which impedance is derivable. For example, when impedance itself is to be monitored in order to determine a substantive physical property of the surrounding tissue, e.g., the type of tissue or its degree of coagulation, the in~t~nt~neous voltage and current of an 20 electrode pair may be sampled, processed and colll,ualed to an RF probe signal that has been applied by signal generator 50 (Figure 2), to provide an actual impedance function. In general, however, the benefits of the invention are achieved in simply detecting the magnitude of a well-defined difference signal, lines F-H, when it is only desired, for example, to confirm that tissue contact by 25 the probe tip has occurred.
Figure 5 is a sch~m~tic block diagram for the operation of a catheter positioning system 100 for controllably positioning an ablation catheter in the cardiac region. As shown in Figure 5, a processor 120 is interconnected with the30 sensing and tre~tment electrodes 12, 13i of catheter 10 via a switching unit 130 comparable to switching unit 42a, 42b of Figure 2A, connected to a signal conditioning circuit 135. Processor 120 controls the switching unit to select spaced electrodes, plGfel~bly two pairs as described above, selected from three or more electrodes, for connection to the signal conditioning circuit, and then 35 receives and evaluates the output of the signal conditioning circuit 135 to detect either the presence of a tissue impedance change at a particular selected electrode, or the value of the local tissue impedance. Signal conditioning circuit 135 may include an arrangement of dirr~relltial amplifiers as described above, and 2 1~3~1 Z
wo 94/ooosO Pcr/uss3/05782 ~ 9 indicated schematically in the Figure. Alternatively, circuit 135 may include circuit elements only for filtering and amplifying the inter-electrode signals. In that case, the outputs of circuit 135 may be digitized and the microprocessor may digitally combine the output signals to obtain a dirr~lential impedance function.
s In a variation as described above, an alternative embodiment may have its electrodes fixedly connected to an array of dirrelential signal amplifiers.
In that embodiment, the outputs of the signal conditioning amplifiers are switchably sampled via an n:4 switching unit under the control of the processor o 120 and similar to unit 130, but located between the signal conditioner 135 and processor 120.
In either case, processor 120 correlates the ~etected electrode signals with particular ones of the electrodes, preferably by polling them in an orderedsequence, and drives and synchronizes a display 140 to represent the detected tissue characteristics. Display 140 may, for example, depict the probe with a variable marker - such as a LED bar display or a plurality of discrete LEDs mounted on a graphic representation of the catheter. The LEDS are ~ct~1~ted by the processor to display the processed information. Specifically, display 140 may show the site along the probe at which the dirr~rel-lial impedance change has been detecte~l by illllmin~ting a LED at that location; or may show which electrodes are in contact with tissue by illllmin~ting a special colored light at the corresponding electrode location. It may also show information such as displaying the relative portion of the probe which has been inserted into the heart.
2s This may be done by selectively ill~lmin~ting LED markers along that portion of the displayed image of the probe colle~onding to one or more detected impedances or signal conditions which indicate that a longit~-din~lly extending region of the probe body has passed a heart valve, or resides inside a closed tissue structure.
Processor i20, in addition to executing one or more logical programs to determine and display probe disposition corresponding to the detected dirr~.ell~ial electrode signals, preferably is part of a cardiac ablation or electrosurgery control s~ ~Lem. In that case the processor also provides a signal along line 142 to the RF power control unit 45 of the system, for controlling the level of power applied to the probe tip. Some forms of coagulation or ablation power control are conventional, for example, programmed control to apply a sufficient power level, based on sensed whole body tissue impedance, to destroy WO 94/00050 Z139~Z PCI /US93/05782 tissue locally at the tip electrode without causing damage to non-involved tissue.
In accordance with the coagulation control aspect of the present invention, the processor detects the electrode disposition, and provides a signal to the power control unit 45 to adjust the level of localized power based further on the area of s contact of the tip electrode, which is derived, by microprocessor 120, from the magnitude ofthe dirre.~.llial impedance signal. Thus, for example, when the tip achieves only partial contact, as indicated by a ~etecte~l charge curve that has a sharply defined shape but still has a relatively high impedance value, the ablation power may be reduced from the conventionally-selected level, to a lower level l0 that limits the amount of ablation energy applied to the contact point. Thus, rather than allowing coagulation to extend into the bloodstream as could occur if the power were delivered based on the as~u~ lion of full electrode contact to the vessel wall tissue, a smaller pulse of energy is applied to affect only the smaller area of tissue actually cont~cting the electrode.
Other variations and modifications adapting the dirrelential signal sensing electrodes and system of the present invention to known cardiac mapping or ablation systems and probes will occur to those skilled in the art, and all such variations and modifications are considered to be within the spirit and scope of the 20 invention to which patent rights are sought, as set forth in the claims appended hereto.
Claims (13)
1. A system for detecting the relative disposition of a multi-electrode catheter assembly inserted along a vessel of a patient, such system comprising signal applying means for applying a sensing signal for propagation between two electrode sets disposed along said multi-electrode catheter, to produce a sensing output of each electrode set corresponding to a measure of local tissue impedance pathways, and means for combining the sensing output of each of the two electrode sets into a differential signal.
2. The system of claim 1, wherein the means for combining normalizes a value of a sensing output based on electrode geometry to normally produce a null signal.
3. The system of claim 1, wherein the combining means includes a first and a second amplifier for amplifying propagation signals from said first and said second electrode set, respectively, and at least one of said amplifiers has a gain selected so that both amplifiers produce outputs of equal magnitude when the first and second electrode sets are immersed in blood.
4. The system of claim 3, wherein a said amplifier has a gain inversely proportional to an effective conductive area of an electrode of one ofsaid sets.
5. The system of claim 1, wherein said means for combining includes current sensing elements for producing an instantaneous current output for each electrode set, and means for functionally combining instantaneous current outputs of different electrode sets.
6. The system of claim 5, wherein said means for functionally combining includes a multi-winding transformer.
7. The system of claim 1, further comprising switching means for selectively interconnecting different electrodes of the catheter assembly to the means for combining.
8. The system of claim 1, wherein plural electrodes of said catheter are connected to different sensing circuits, and further comprising switching means for selectively sampling outputs of different sensing circuits to determine tissue characteristics associated with different regions along the catheter.
9. The system of claim 1, further comprising display means for displaying a representation of the catheter, and control means responsive to the differential signal for causing the display means to indicate when a catheter electrode contacts tissue.
10. The system of claim 9, wherein the catheter is a cardiac ablation catheter having an ablation electrode, and the display indicates when the ablation electrode contacts surrounding tissue.
11. The system of claim 10, further comprising means for indicating a degree of electrode contact with surrounding tissue.
12. The system of claim 1, further comprising means for controlling a level of electrosurgical power applied to said catheter in accordance with said differential signal.
13. A catheter positioning system, comprising a signal source means for connecting said signal source between an electrode set including an outer electrode of a multi-electrode catheter means for forming a differential signal by combining signals from a plurality of electrodes of said multi-electrode catheter, the plurality of electrodes including at least one inner electrode, and means for evaluating the differential signal to determine catheter position.
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Application Number | Priority Date | Filing Date | Title |
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US07/906,529 US5341807A (en) | 1992-06-30 | 1992-06-30 | Ablation catheter positioning system |
US07/906,529 | 1992-06-30 |
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CA2139312A1 true CA2139312A1 (en) | 1994-01-06 |
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CA002139312A Abandoned CA2139312A1 (en) | 1992-06-30 | 1993-06-16 | Ablation catheter positioning system |
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EP (1) | EP0648087A4 (en) |
JP (1) | JPH08505291A (en) |
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-
1992
- 1992-06-30 US US07/906,529 patent/US5341807A/en not_active Expired - Lifetime
-
1993
- 1993-06-16 JP JP6502443A patent/JPH08505291A/en active Pending
- 1993-06-16 WO PCT/US1993/005782 patent/WO1994000050A1/en not_active Application Discontinuation
- 1993-06-16 CA CA002139312A patent/CA2139312A1/en not_active Abandoned
- 1993-06-16 EP EP93916580A patent/EP0648087A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JPH08505291A (en) | 1996-06-11 |
EP0648087A1 (en) | 1995-04-19 |
WO1994000050A1 (en) | 1994-01-06 |
EP0648087A4 (en) | 1998-06-10 |
US5341807A (en) | 1994-08-30 |
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Legal Events
Date | Code | Title | Description |
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EEER | Examination request | ||
FZDE | Discontinued |