CA2130014A1 - Improved system for detecting bacterial growth in a plurality or culture vials - Google Patents

Improved system for detecting bacterial growth in a plurality or culture vials

Info

Publication number
CA2130014A1
CA2130014A1 CA2130014A CA2130014A CA2130014A1 CA 2130014 A1 CA2130014 A1 CA 2130014A1 CA 2130014 A CA2130014 A CA 2130014A CA 2130014 A CA2130014 A CA 2130014A CA 2130014 A1 CA2130014 A1 CA 2130014A1
Authority
CA
Canada
Prior art keywords
test station
bacterial growth
rod
sample
vials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2130014A
Other languages
French (fr)
Other versions
CA2130014C (en
Inventor
Klaus W. Berndt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of CA2130014A1 publication Critical patent/CA2130014A1/en
Application granted granted Critical
Publication of CA2130014C publication Critical patent/CA2130014C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00752—Type of codes bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/04—Batch operation; multisample devices
    • G01N2201/0438—Linear motion, sequential
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/10—Scanning
    • G01N2201/101—Scanning measuring head
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus

Abstract

A system for detecting the presence of bacterial growth in a plurality of sample vials incorporates a single test station moveable along each of the plurality of sample vials. In one embodiment, the sensor station is movably mounted on a rod, and that rod is movably mounted on a pair of spaced rods. The rod which carries the test station may move along the spaced rods to change the location of the test station in a first dimension and the test station is moveable along its rod to change location in a second dimension. In this way, the test station may be moved through two dimensions to move serially to the location of each of the plurality of sample vials. In another aspect of this invention, a bar code is associated with each of the sample vials, and the test station makes a reading of that bar code concurrent with a determination being made as to whether there is any bacterial growth in the sample vial. In this way, it is ensured that the results of the evaluation of whether bacterial growth is ongoing will be associated with the proper sample vial. 1n a third aspect of this invention, the sample vial incorporates a plurality of distinct types of bacterial sensors. Thus, the advantages of each of several types of bacterial sensors may be incorporated into a single sample vial.
CA002130014A 1993-08-27 1994-08-12 Improved system for detecting bacterial growth in a plurality or culture vials Expired - Fee Related CA2130014C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/113,444 1993-08-27
US08/113,444 US5397709A (en) 1993-08-27 1993-08-27 System for detecting bacterial growth in a plurality of culture vials

Publications (2)

Publication Number Publication Date
CA2130014A1 true CA2130014A1 (en) 1995-02-28
CA2130014C CA2130014C (en) 2001-02-20

Family

ID=22349453

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002130014A Expired - Fee Related CA2130014C (en) 1993-08-27 1994-08-12 Improved system for detecting bacterial growth in a plurality or culture vials

Country Status (6)

Country Link
US (2) US5397709A (en)
EP (1) EP0640826B1 (en)
JP (1) JPH0829116B2 (en)
AU (1) AU679078B2 (en)
CA (1) CA2130014C (en)
DE (1) DE69429310T2 (en)

Families Citing this family (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858769A (en) * 1989-05-15 1999-01-12 Akzo Nobel N.V. Device for detecting microorganisms
CA2156281A1 (en) * 1993-02-17 1994-09-01 Anthony Hugh Carr Improvements in or relating to monitoring
US5580784A (en) * 1993-09-29 1996-12-03 Becton Dickinson And Company Data collection apparatus for use with chemical sensors
US6387651B1 (en) 1995-04-12 2002-05-14 Biolog, Inc. Comparative phenotype analysis of two or more microorganisms using a plurality of substrates within a microwell device
US6340588B1 (en) * 1995-04-25 2002-01-22 Discovery Partners International, Inc. Matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6352854B1 (en) 1995-04-25 2002-03-05 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6025129A (en) * 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5925562A (en) * 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
US5741462A (en) 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6319668B1 (en) 1995-04-25 2001-11-20 Discovery Partners International Method for tagging and screening molecules
CA2179364C (en) * 1995-06-27 1999-09-28 Klaus W. Berndt Method and apparatus for detecting microorganisms
US5891739A (en) * 1995-06-27 1999-04-06 Becton Dickinson And Company Multiple sample container
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5798514A (en) * 1996-01-11 1998-08-25 Accumed Inc. Circular bar code
US5705384A (en) * 1996-05-16 1998-01-06 Becton Dickinson And Company Compact high-volume microorganism detection apparatus
GB2313188B (en) * 1996-05-17 1999-10-20 Pfizer Ltd Spectrophotometric analysis
US6171554B1 (en) * 1996-10-02 2001-01-09 Matrix Technologies Corporation Apparatus and method for alphanumerically identifying and arranging test tubes
US6166761A (en) * 1997-01-09 2000-12-26 Interface Multigrad Technology Method and apparatus for monitoring a biological sample
GB9714347D0 (en) * 1997-07-09 1997-09-10 Oxoid Ltd Image analysis systems and devices for use therewith
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
DE10011529T1 (en) 1998-05-01 2011-09-01 Gen-Probe Incorporated Automatic diagnostic analyzer and method
EP0953838A1 (en) * 1998-05-01 1999-11-03 F. Hoffmann-La Roche Ag Apparatus for simultaneously monitoring reactions taking place in a plurality of reaction vessels
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
WO1999060381A1 (en) * 1998-05-16 1999-11-25 The Perkin-Elmer Corporation Instrument for monitoring polymerase chain reaction of dna
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
WO1999060380A1 (en) * 1998-05-19 1999-11-25 Cepheid Multi-channel optical detection system
GB9818176D0 (en) * 1998-08-21 1998-10-14 Aromascan Plc Method for detecting microorganisms
FR2784188B1 (en) * 1998-10-05 2000-12-22 Commissariat Energie Atomique BIOCHIP AND DEVICE FOR READING A BIOCHIP COMPRISING A PLURALITY OF MOLECULAR RECOGNITION AREAS
FR2784189B3 (en) * 1998-10-05 2000-11-03 Commissariat Energie Atomique BIOCHIP AND DEVICE FOR READING A BIOCHIP COMPRISING A PLURALITY OF MOLECULAR RECOGNITION AREAS
EP1147394A1 (en) * 1998-12-15 2001-10-24 Union Carbide Chemicals & Plastics Technology Corporation Apparatus and methods for combinatorial chemical analysis
US6251624B1 (en) * 1999-03-12 2001-06-26 Akzo Nobel N.V. Apparatus and method for detecting, quantifying and characterizing microorganisms
US6271022B1 (en) * 1999-03-12 2001-08-07 Biolog, Inc. Device for incubating and monitoring multiwell assays
NL1011664C2 (en) * 1999-03-24 2000-05-15 Datascan Group B V Apparatus and method for selecting and capturing an image that is part of an irradiated or emitting object.
JP3597729B2 (en) * 1999-05-11 2004-12-08 日立ソフトウエアエンジニアリング株式会社 Fluorescence metering method and fluorescence meter
JP3815969B2 (en) * 1999-05-12 2006-08-30 アクララ バイオサイエンシーズ， インコーポレイテッド Multiplex fluorescence detection in microfluidic devices
US7423750B2 (en) * 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US20050279949A1 (en) * 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US6696239B1 (en) 2000-04-20 2004-02-24 Biolog, Inc. Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials
US6563581B1 (en) * 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
US20030160957A1 (en) * 2000-07-14 2003-08-28 Applera Corporation Scanning system and method for scanning a plurality of samples
US6673532B2 (en) 2000-08-14 2004-01-06 University Of Maryland, Baltimore County Bioreactor and bioprocessing technique
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7829025B2 (en) * 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7635588B2 (en) * 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
EP3312594B1 (en) 2002-05-17 2019-07-24 Life Technologies Corporation Apparatus for differentiating multiple fluorescence signals by excitation wavelength
DE60321090D1 (en) 2002-06-26 2008-07-03 Avery Dennison Corp Longitudinal polymer films
WO2004003444A1 (en) * 2002-06-27 2004-01-08 I.M.T. Interface Multigrad Technology Ltd. Changing the temperature of a liquid sample and a receptacle useful therefor
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
JP2005006553A (en) * 2003-06-19 2005-01-13 Olympus Corp Apparatus for cell culture detection
WO2005009126A1 (en) * 2003-07-23 2005-02-03 Essen Instruments, Inc. Examination systems for biological samples
EP2402089A1 (en) 2003-07-31 2012-01-04 Handylab, Inc. Processing particle-containing samples
US20050127279A1 (en) * 2003-08-15 2005-06-16 Harris Martin R. Multiplexed fiber optic sensor system
US7067323B2 (en) * 2003-10-15 2006-06-27 Lighthouse Instruments, Llc System and method for automated headspace analysis
CA2552717C (en) 2004-01-07 2011-11-29 Levtech, Inc. Mixing bag with integral sparger and sensor receiver
DE102004017039A1 (en) * 2004-04-02 2005-11-03 Rwth Aachen Method and device for detecting process parameters of reaction liquids in a plurality of shaken microreactors
ES2553097T3 (en) 2004-05-03 2015-12-04 Handylab, Inc. Processing of samples containing polynucleotides
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
JP4767536B2 (en) * 2004-12-28 2011-09-07 オリンパス株式会社 Culture observation equipment
US20060166305A1 (en) * 2005-01-27 2006-07-27 Genetix Limited Animal cell confluence detection method and apparatus
US7310147B2 (en) * 2005-01-27 2007-12-18 Genetix Limited Robotic apparatus for picking of cells and other applications with integrated spectroscopic capability
US8008066B2 (en) 2005-03-10 2011-08-30 Gen-Probe Incorporated System for performing multi-formatted assays
US20060264779A1 (en) 2005-05-09 2006-11-23 Kemp Timothy M Fluidic medical devices and uses thereof
WO2007044917A2 (en) * 2005-10-11 2007-04-19 Handylab, Inc. Polynucleotide sample preparation device
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US8372340B2 (en) 2005-10-19 2013-02-12 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
EP2001990B1 (en) 2006-03-24 2016-06-29 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) * 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
AU2013205256B8 (en) * 2007-07-13 2015-10-22 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
CN104502579B (en) 2007-10-02 2018-04-13 赛拉诺斯知识产权有限责任公司 Modular point-of-care devices and its application
WO2009049675A1 (en) * 2007-10-17 2009-04-23 Agilent Technologies, Inc. Measurement device with motion-triggered data exchange
WO2009103003A2 (en) * 2008-02-15 2009-08-20 Bio-Rad Laboratories, Inc. Scanning fluorescent reader with diffuser system
US20100009351A1 (en) * 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide Capture Materials, and Method of Using Same
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
CN102460183B (en) 2009-05-15 2015-04-15 生物梅里埃有限公司 Automated loading mechanism for microbial detection apparatus
WO2010132823A2 (en) 2009-05-15 2010-11-18 Biomerieux, Inc. System and methods for rapid identification and/or characterization of a microbial agent in a sample
US8862448B2 (en) 2009-10-19 2014-10-14 Theranos, Inc. Integrated health data capture and analysis system
JP5799086B2 (en) 2010-05-14 2015-10-21 ビオメリュー・インコーポレイテッド Identification and / or characterization of microbial factors using taxonomic hierarchy classification
EP2749887A3 (en) 2010-07-23 2014-10-01 Beckman Coulter, Inc. System Or Method Of Including Analytical Units
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
EP2666008B1 (en) 2011-01-21 2021-08-11 Labrador Diagnostics LLC Systems and methods for sample use maximization
US8718948B2 (en) 2011-02-24 2014-05-06 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
BR112013026451B1 (en) 2011-04-15 2021-02-09 Becton, Dickinson And Company system and method to perform molecular diagnostic tests on several samples in parallel and simultaneously amplification in real time in plurality of amplification reaction chambers
WO2012151473A2 (en) 2011-05-04 2012-11-08 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
US9121827B2 (en) 2011-06-30 2015-09-01 Mocon, Inc. Method of contemporaneously monitoring changes in analyte concentration in a plurality of samples on individual schedules
EP4016051A1 (en) * 2011-08-17 2022-06-22 Agilent Technologies, Inc. Tool and method for validating operational performance of a photoluminescence based analytical instrument
EP2761305B1 (en) 2011-09-30 2017-08-16 Becton, Dickinson and Company Unitized reagent strip
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
EP2773892B1 (en) 2011-11-04 2020-10-07 Handylab, Inc. Polynucleotide sample preparation device
EP3373015A1 (en) 2011-11-07 2018-09-12 Beckman Coulter Inc. Aliquotter system and workflow
JP6062449B2 (en) 2011-11-07 2017-01-18 ベックマン コールター， インコーポレイテッド Specimen container detection
KR20140091032A (en) 2011-11-07 2014-07-18 베크만 컬터, 인코포레이티드 Magnetic damping for specimen transport system
CN104040352B (en) 2011-11-07 2016-09-07 贝克曼考尔特公司 Mechanical arm
EP2776843B1 (en) 2011-11-07 2019-03-27 Beckman Coulter, Inc. Centrifuge system and workflow
EP2776848B1 (en) 2011-11-07 2019-12-25 Beckman Coulter, Inc. System and method for transporting sample containers
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
CA2804843C (en) * 2012-02-06 2021-02-02 Ortho-Clinical Diagnostics, Inc. Multiple time windows for extending the range of an assay
US10475527B2 (en) 2012-03-22 2019-11-12 Biomerieux, Inc. Method and system for detection of microbial growth in a specimen container
US8935001B2 (en) 2012-03-29 2015-01-13 bioMeriéux, Inc. System and method for establishing and/or maintaining proper alignment of a robotic transfer mechanism
KR102055611B1 (en) * 2012-08-17 2019-12-13 넥서스 디엑스, 아이엔씨. Test platform, test apparatus and control method thereof
WO2014086411A1 (en) 2012-12-05 2014-06-12 Luxcel Biosciences Limited Individually and flexibly deployable target-analyte sensitive particulate probes and method of making and using
US9684005B2 (en) * 2013-12-06 2017-06-20 BL Photonics Inc. Apparatus and method for spectroscopic analysis of vinification liquids using coded sample containers
AU2015335904B2 (en) 2014-10-21 2020-09-03 Gen-Probe Incorporated Method and apparatus for printing on an object having a curved surface
CN109563457A (en) 2016-05-27 2019-04-02 生物梅里埃有限公司 The system and method for sample container are transported between detecting instrument
EP3463102B1 (en) 2016-05-27 2022-07-06 bioMerieux, Inc. System and method of load balancing specimen containers within detection instruments
ES2807194T3 (en) * 2016-06-30 2021-02-22 Esco Medical Aps An apparatus for the incubation of a biological material
JP6698451B2 (en) * 2016-07-11 2020-05-27 オリンパス株式会社 Observation device
JP6815787B2 (en) * 2016-08-09 2021-01-20 オリンパス株式会社 Observation device, control method of observation device, control program of observation device
DE102016116377A1 (en) 2016-09-01 2018-03-01 Rheinisch-Westfälisch Technische Hochschule (RWTH) Aachen Method and device for detecting process parameters in liquid cultures
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
WO2018206746A1 (en) 2017-05-10 2018-11-15 Luxcel Biosciences Limited Real-time cellular or pericellular microenvironmental oxygen control
CN110621586A (en) 2017-05-16 2019-12-27 安捷伦科技有限公司 Headspace-eliminating microtiter plate cover and method for optically measuring the oxygen concentration of a well through the cover
WO2022256580A1 (en) * 2021-06-02 2022-12-08 Richard Postrel Instant bio-sensing for the detection of early onset diseases
WO2023196546A1 (en) 2022-04-08 2023-10-12 Agilent Technologies, Inc. Headspace eliminating microtiter plate lid
WO2023196547A1 (en) 2022-04-08 2023-10-12 Agilent Technologies, Inc. Microtiter plate lid and magnetic adapter

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3781120A (en) * 1970-09-14 1973-12-25 Technicon Instr Self-locating sample receptacle having integral identification label
US3773426A (en) * 1972-02-22 1973-11-20 Department Of Health Educ Welf Bacterial growth detector
CA1020068A (en) * 1975-06-10 1977-11-01 Edward T. Sheaff Device for examining biological specimens
US4115010A (en) * 1976-02-03 1978-09-19 Merck & Co., Inc. Automated plate reader
US4116775A (en) * 1976-05-03 1978-09-26 Mcdonnell Douglas Corporation Machine and process for reading cards containing medical specimens
FR2368709A1 (en) * 1976-10-19 1978-05-19 Pasteur Institut AUTOMATIC PHOTOMETER
US4349510A (en) * 1979-07-24 1982-09-14 Seppo Kolehmainen Method and apparatus for measurement of samples by luminescence
EP0025350A3 (en) * 1979-09-05 1981-06-10 Dynatech Ag Apparatus for detecting luminescent reactions
JPS57132038A (en) * 1981-02-10 1982-08-16 Olympus Optical Co Ltd Photometric device
US4397560A (en) * 1981-04-23 1983-08-09 Bio-Tek Instruments, Inc. Photometer with microtray well position indicator
AU566435B2 (en) * 1983-12-05 1987-10-22 Becton Dickinson & Company Identification of microorganisms by infrared analysis of evolved carbon dioxide
US4657870A (en) * 1984-04-23 1987-04-14 Ryder International Corporation Incubator optical system for viewing sterilization indicator
DE3420760A1 (en) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen LIGHTING DEVICE FOR THE OPTICAL, IN PARTICULAR IMAGE ANALYTICAL EVALUATION OF MICROBIOLOGICAL OBJECTS
US4772453A (en) * 1985-03-01 1988-09-20 Lisenbee Wayne F Luminiscence measurement arrangement
US5096807A (en) * 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US4678894A (en) * 1985-04-18 1987-07-07 Baxter Travenol Laboratories, Inc. Sample identification system
CH669851A5 (en) * 1986-03-06 1989-04-14 Tecan Ag
GB8607975D0 (en) * 1986-04-01 1986-05-08 Fisons Plc Devices
GB2190195A (en) * 1986-05-09 1987-11-11 Cambridge Life Sciences Microtitre plate reader
US4861727A (en) * 1986-09-08 1989-08-29 C. R. Bard, Inc. Luminescent oxygen sensor based on a lanthanide complex
US5164796A (en) * 1988-03-15 1992-11-17 Akzo N.V. Apparatus and method for detection of microorganisms
US4945060A (en) * 1988-03-15 1990-07-31 Akzo N. V. Device for detecting microorganisms
US5268304A (en) * 1988-10-13 1993-12-07 The United States Of America As Represented By The Secretary Of The Navy Method of determining the concentration of a chemical of interest in a solution
JP2897027B2 (en) * 1988-10-27 1999-05-31 スズキ株式会社 Immunological agglutination detector
CA1329263C (en) * 1989-03-01 1994-05-03 Mark Krichever Bar code scanner
JP2750605B2 (en) * 1989-05-17 1998-05-13 スズキ株式会社 Particle aggregation pattern determination method
US5082628A (en) * 1989-09-19 1992-01-21 Park Pharmaceuticals, Inc. Luminometer
JPH087222B2 (en) * 1990-01-18 1996-01-29 持田製薬株式会社 Automatic dispensing dilution device
FR2659142B1 (en) * 1990-03-02 1992-06-05 Gespac Instr Sa ANALYZER FOR BLOOD GROUPING.
DE69024631T2 (en) * 1990-03-29 1996-09-19 Avl Photronics Corp Method and apparatus for the detection of biological activities in a sample
JPH0678978B2 (en) * 1990-05-25 1994-10-05 スズキ株式会社 Aggregation pattern detector
DE4109118C2 (en) * 1991-03-20 1995-04-06 Lange Gmbh Dr Bruno Method for the automatic evaluation of a sample component of a water sample
DE4123817C2 (en) * 1991-07-18 1994-06-09 Berthold Lab Prof Dr Radiation measuring device, in particular for measuring luminescence
US5290701A (en) * 1991-08-28 1994-03-01 Wilkins Judd R Microbial detection system and process
US5304492A (en) * 1991-11-26 1994-04-19 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Spectrophotometer for chemical analyses of fluids
DE69330772T2 (en) * 1992-03-09 2002-07-04 Accumed Internat Inc DIAGNOSTIC MICROBIOLOGICAL TEST DEVICE AND METHOD
US5302813A (en) * 1992-04-02 1994-04-12 Symbol Technologies, Inc. Multi-bit digitizer
US5401465A (en) * 1992-05-05 1995-03-28 Chiron Corporation Luminometer with reduced sample crosstalk
US5432061A (en) * 1992-09-01 1995-07-11 Becton Dickinson And Company Method and apparatus for detecting microorganisms

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JPH07163394A (en) 1995-06-27
EP0640826B1 (en) 2001-12-05
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US5397709A (en) 1995-03-14
CA2130014C (en) 2001-02-20
DE69429310D1 (en) 2002-01-17
AU679078B2 (en) 1997-06-19
AU7020394A (en) 1995-03-09
DE69429310T2 (en) 2002-07-18
US5595708A (en) 1997-01-21

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