CA2129242A1 - Method and apparatus for controlled environment electrotransport - Google Patents

Method and apparatus for controlled environment electrotransport

Info

Publication number
CA2129242A1
CA2129242A1 CA002129242A CA2129242A CA2129242A1 CA 2129242 A1 CA2129242 A1 CA 2129242A1 CA 002129242 A CA002129242 A CA 002129242A CA 2129242 A CA2129242 A CA 2129242A CA 2129242 A1 CA2129242 A1 CA 2129242A1
Authority
CA
Canada
Prior art keywords
electrotransport
methods
control
arrangement
active electrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002129242A
Other languages
French (fr)
Other versions
CA2129242C (en
Inventor
Joseph Bradley Phipps
Lyn Cammarano Moodie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Joseph Bradley Phipps
Lyn Cammarano Moodie
Medtronic, Inc.
Alza Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/502,232 priority Critical patent/US5125894A/en
Priority to AU13593/92A priority patent/AU1359392A/en
Priority to PCT/US1992/000796 priority patent/WO1993014813A1/en
Priority to DE69218629T priority patent/DE69218629T2/en
Priority to EP92905287A priority patent/EP0625061B1/en
Priority to CA002129242A priority patent/CA2129242C/en
Priority to JP50573692A priority patent/JP3368322B2/en
Application filed by Joseph Bradley Phipps, Lyn Cammarano Moodie, Medtronic, Inc., Alza Corporation filed Critical Joseph Bradley Phipps
Publication of CA2129242A1 publication Critical patent/CA2129242A1/en
Priority to US08/173,149 priority patent/US5443442A/en
Priority to US08/451,119 priority patent/US5622530A/en
Priority to US08/452,403 priority patent/US5591124A/en
Application granted granted Critical
Publication of CA2129242C publication Critical patent/CA2129242C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0444—Membrane

Abstract

Methods for conducting controlled environment electrotransport are described.
The methods generally concern control of the ionic environment of the active electrode reservoir, in an electrotransport system. This control may be utilized, for example, to maintain a constant extraneous ion presence, such as pH. It may also be applied in a preferred manner to maintain selected con-trol over the delivery rate of a target species, in time, in the presence of extraneous ions. Apparatus usable to provide for con-trolled environment electrotransport are also described. In general the apparatus comprises an electrotransport system (5) includ-ing an active electrode reservoir (6) having therein both a primary electrode arrangement (30) and a secondary electrode arrange-ment (50), with a control arrangement (40) for selected operation of both. The secondary electrode arrangement (50), being operated different from the primary electrode arrangement (30), is selected for operation to selectively enhance or otherwise mod-ify ion presence in the active electrode reservoir (6), to achieve application of the general methods described. The apparatus may include a sensor means (60) therein, for use as feedback to a control system (40) during operation. Methods and systems involv-ing diffusion type delivery are also described.
CA002129242A 1990-03-30 1992-02-03 Method and apparatus for controlled environment electrotransport Expired - Lifetime CA2129242C (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US07/502,232 US5125894A (en) 1990-03-30 1990-03-30 Method and apparatus for controlled environment electrotransport
DE69218629T DE69218629T2 (en) 1990-03-30 1992-02-03 DEVICE FOR REGULATED IONTOPHORESIS
EP92905287A EP0625061B1 (en) 1990-03-30 1992-02-03 Apparatus for controlled iontophoresis
CA002129242A CA2129242C (en) 1990-03-30 1992-02-03 Method and apparatus for controlled environment electrotransport
JP50573692A JP3368322B2 (en) 1990-03-30 1992-02-03 Controlled ion introduction method and apparatus
PCT/US1992/000796 WO1993014813A1 (en) 1990-03-30 1992-02-03 Method and apparatus for controlled iontophoresis
AU13593/92A AU1359392A (en) 1990-03-30 1992-02-03 Method and apparatus for controlled iontophoresis
US08/173,149 US5443442A (en) 1990-03-30 1993-12-22 Method and apparatus for controlled environment electrotransport
US08/451,119 US5622530A (en) 1990-03-30 1995-05-26 Method and apparatus for controlled environment electrotransport
US08/452,403 US5591124A (en) 1990-03-30 1995-05-26 Method and apparatus for controlled environment electrotransport

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/502,232 US5125894A (en) 1990-03-30 1990-03-30 Method and apparatus for controlled environment electrotransport
CA002129242A CA2129242C (en) 1990-03-30 1992-02-03 Method and apparatus for controlled environment electrotransport
PCT/US1992/000796 WO1993014813A1 (en) 1990-03-30 1992-02-03 Method and apparatus for controlled iontophoresis

Publications (2)

Publication Number Publication Date
CA2129242A1 true CA2129242A1 (en) 1993-08-05
CA2129242C CA2129242C (en) 2001-12-25

Family

ID=25677410

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002129242A Expired - Lifetime CA2129242C (en) 1990-03-30 1992-02-03 Method and apparatus for controlled environment electrotransport

Country Status (7)

Country Link
US (4) US5125894A (en)
EP (1) EP0625061B1 (en)
JP (1) JP3368322B2 (en)
AU (1) AU1359392A (en)
CA (1) CA2129242C (en)
DE (1) DE69218629T2 (en)
WO (1) WO1993014813A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6330471B1 (en) 1996-03-17 2001-12-11 Hisamitsu Pharmaceutical Co., Ltd. Iontophoresis electrode device

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US6004309A (en) 1990-03-30 1999-12-21 Alza Corporation Method and apparatus for controlled environment electrotransport
US6575957B1 (en) * 1990-11-01 2003-06-10 Robert Tapper Iontophoretic treatment system
US5431625A (en) * 1991-02-01 1995-07-11 Empi, Inc. Iontophoresis electronic device having a ramped output current
US5464387A (en) * 1991-07-24 1995-11-07 Alza Corporation Transdermal delivery device
WO1993007920A1 (en) * 1991-10-24 1993-04-29 Insutech, Incorporated Gas pressure driven infusion system by hydrogel electrolysis
JP2542792B2 (en) * 1992-11-05 1996-10-09 ベクトン・ディッキンソン・アンド・カンパニー User-operated iontophoretic device
US5427585A (en) * 1993-03-29 1995-06-27 Bettinger; David S. On-demand iontophoretic system
CA2126487C (en) * 1993-06-23 2001-05-29 Keiichiro Okabe Iontophoresis device
AU699648B2 (en) * 1993-09-03 1998-12-10 Alza Corporation Reduction of skin irritation and resistance during electrotransport
US5533971A (en) * 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
US20050159700A1 (en) * 1993-09-30 2005-07-21 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US5871460A (en) * 1994-04-08 1999-02-16 Alza Corporation Electrotransport system with ion exchange material providing enhanced drug delivery
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
FR2726769B1 (en) * 1994-11-16 1997-01-31 Lhd Lab Hygiene Dietetique IONOPHORETIC DEVICE FOR TRANSDERMAL DELIVERY OF MEDICINES AND DISPOSABLE ASSEMBLY FORMING SUCH A DEVICE
US5624415A (en) * 1995-04-24 1997-04-29 Alza Corporation Reduction of skin irritation and resistance during electrotransport
ZA964320B (en) * 1995-06-05 1997-01-13 Alza Corp Device for transdermal electrotransport delivery of fentanyl and sufentanil
US6881208B1 (en) * 1995-06-05 2005-04-19 Joseph B. Phipps Method and device for transdermal electrotransport delivery of fentanyl and sufentanil
US7572252B1 (en) * 1995-06-07 2009-08-11 Alza Corporation Electrotransport agent delivery method and apparatus
US6355025B1 (en) * 1995-06-07 2002-03-12 Alza Corporation Adjustable electrotransport drug delivery using a fixed output controller
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US5788666A (en) * 1995-06-15 1998-08-04 Empi, Inc. Iontophoresis electrode
US5840056A (en) * 1995-06-15 1998-11-24 Empi, Inc. Iontophoresis electrode
US5595635A (en) * 1995-09-08 1997-01-21 The United States Of America As Represented By The Secretary Of The Navy Apparatus for measuring lead content of water
US5989409A (en) * 1995-09-11 1999-11-23 Cygnus, Inc. Method for glucose sensing
WO1997011742A1 (en) * 1995-09-28 1997-04-03 Becton Dickinson And Company Iontophoretic drug delivery system, including disposable patch
US5954685A (en) * 1996-05-24 1999-09-21 Cygnus, Inc. Electrochemical sensor with dual purpose electrode
US6086572A (en) * 1996-05-31 2000-07-11 Alza Corporation Electrotransport device and method of setting output
US6718201B1 (en) 1996-06-07 2004-04-06 Alza Corporation Electrotransport agent delivery method and apparatus
WO1997048444A1 (en) * 1996-06-19 1997-12-24 Becton Dickinson And Company Iontophoretic delivery of cell adhesion inhibitors
US6350259B1 (en) * 1996-09-30 2002-02-26 Vyteris, Inc. Selected drug delivery profiles using competing ions
US6139718A (en) 1997-03-25 2000-10-31 Cygnus, Inc. Electrode with improved signal to noise ratio
US6004577A (en) * 1997-08-12 1999-12-21 Murdock; Thomas O. Enhanced electrotransport of therapeutic agents having polybasic anionic counter ions
DK1047475T3 (en) 1997-12-17 2007-06-11 Alza Corp Iontophoresis with programmed electrical current adjustment
WO1999038564A1 (en) * 1998-01-28 1999-08-05 Alza Corporation Electrochemically reactive cathodes for an electrotransport device
DK1051220T3 (en) 1998-01-28 2005-02-14 Alza Corp Electrotransport electrode assembly with lower initial resistance
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
US7476250B1 (en) * 1999-04-06 2009-01-13 Mansmann Kevin A Semi-permeable membranes to assist in cartilage repair
EP1171195B1 (en) 1999-04-16 2005-03-16 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
US7074747B1 (en) * 1999-07-01 2006-07-11 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
US20050009717A1 (en) * 1999-07-01 2005-01-13 Lukenbach Elvin R. Foaming make-up removing cleansing compositions
WO2001001949A1 (en) 1999-07-01 2001-01-11 Johnson And Johnson Consumer Companies, Inc. Cleansing compositions
US6762158B2 (en) 1999-07-01 2004-07-13 Johnson & Johnson Consumer Companies, Inc. Personal care compositions comprising liquid ester mixtures
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6629968B1 (en) * 2000-06-30 2003-10-07 Vyteris, Inc. Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6553255B1 (en) 2000-10-27 2003-04-22 Aciont Inc. Use of background electrolytes to minimize flux variability during iontophoresis
US6591133B1 (en) * 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8541021B2 (en) * 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
DE60239528D1 (en) * 2001-05-01 2011-05-05 Corium International Redwood City TWO-PHASE, WATER-ABSORBING BIOADHESIVE COMPOSITION
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
ES2331302T3 (en) 2001-05-01 2009-12-29 A.V. Topchiev Institute Of Petrochemical Synthesis HYDROGEL COMPOSITIONS.
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US20030065285A1 (en) * 2001-07-23 2003-04-03 Higuchi William I. Method and apparatus for increasing flux during reverse iontophoresis
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
WO2003092764A2 (en) * 2002-04-29 2003-11-13 Kevin Marchitto Controlled release transdermal drug delivery
JP4089875B2 (en) * 2002-06-12 2008-05-28 共同印刷株式会社 Electrode device including a recess
DE60313353T2 (en) * 2002-10-04 2007-08-16 Photokinetix Inc. PHOTOKINETIC DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES USING PULSATIVE INKOHAERENTEM LIGHT.
US7031769B2 (en) * 2003-02-21 2006-04-18 Birch Point Medical, Inc. Dosage control electrode for iontophoresis device
WO2004080441A1 (en) * 2003-03-10 2004-09-23 Tokuyama Corporation Patch material for ionic medicine administration
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US7480530B2 (en) 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Device for treatment of barrier membranes
US7479133B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Methods of treating acne and rosacea with galvanic generated electricity
AU2005210504B2 (en) * 2004-01-30 2009-01-08 Merck Sharp & Dohme Corp. Crystalline polymorphs of a CXC-chemokine receptor ligand
CA2554649C (en) 2004-01-30 2015-10-27 Corium International, Inc. Rapidly dissolving film for delivery of an active agent
CA2576158C (en) * 2004-08-05 2020-10-27 Corium International, Inc. Adhesive composition
IL165365A0 (en) 2004-11-24 2006-01-15 Q Core Ltd Finger-type peristaltic pump
US7856263B2 (en) * 2005-04-22 2010-12-21 Travanti Pharma Inc. Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
CA2612866A1 (en) * 2005-05-11 2006-11-23 Corium International, Inc. Permeabilization of biological membranes
US20070025869A1 (en) * 2005-07-15 2007-02-01 Gordon John H Fluid Delivery Device
WO2007046103A2 (en) * 2005-10-19 2007-04-26 Perf-Action Technologies Ltd. System for iontophoretic transdermal delivery of polymeric agents and methods of use thereof
US8036738B2 (en) * 2006-03-14 2011-10-11 New Jersey Institute Of Technology Iontophoretic transdermal drug delivery system based on conductive polyaniline membrane
US8214030B2 (en) * 2006-09-06 2012-07-03 Encore Medical Asset Corporation Iontophoresis apparatus and method
US7996077B2 (en) * 2006-09-06 2011-08-09 Encore Medical Asset Corporation Iontophoresis apparatus and method
US8025634B1 (en) * 2006-09-18 2011-09-27 Baxter International Inc. Method and system for controlled infusion of therapeutic substances
US8332028B2 (en) * 2006-11-28 2012-12-11 Polyplus Battery Company Protected lithium electrodes for electro-transport drug delivery
US20080147186A1 (en) * 2006-12-14 2008-06-19 Joshi Ashok V Electrochemical Implant For Delivering Beneficial Agents
US20080172107A1 (en) * 2007-01-11 2008-07-17 Mcginnis William J Stand alone osteogenic stimulus device and method of using
US20080172106A1 (en) * 2007-01-11 2008-07-17 Mcginnis William J Osteogenic stimulus device, kit and method of using thereof
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
US20080188791A1 (en) * 2007-02-02 2008-08-07 Difiore Attilio E Active iontophoresis delivery system
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
WO2009000262A1 (en) * 2007-06-25 2008-12-31 Acino Ag Electrophoretic transdermal application system
EP2164418B1 (en) * 2007-06-27 2014-01-08 The General Hospital Corporation Apparatus for optical inhibition of photodynamic therapy
WO2009006349A2 (en) * 2007-06-29 2009-01-08 Polyplus Battery Company Electrotransport devices, methods and drug electrode assemblies
US20090069740A1 (en) * 2007-09-07 2009-03-12 Polyplus Battery Company Protected donor electrodes for electro-transport drug delivery
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US8150525B2 (en) 2008-08-27 2012-04-03 Johnson & Johnson Consumer Companies, Inc. Treatment of hyperhydrosis
US7963855B2 (en) 2008-11-12 2011-06-21 Nike, Inc. Releasable connections for golf club heads and shafts
AU2010204986B2 (en) 2009-01-14 2016-06-02 Corium International, Inc. Transdermal administration of tamsulosin
US20120089232A1 (en) 2009-03-27 2012-04-12 Jennifer Hagyoung Kang Choi Medical devices with galvanic particulates
BR112012011411A2 (en) 2009-11-13 2017-12-12 Johnson & Johnson Consumer Companies Inc galvanic skin care device
DE102010002598A1 (en) * 2010-03-04 2011-09-08 Acino Ag Activatable drug delivery system
US9610440B2 (en) * 2013-06-10 2017-04-04 Iontera, Inc Systems, devices, and methods for transdermal delivery
US11289700B2 (en) 2016-06-28 2022-03-29 The Research Foundation For The State University Of New York KVOPO4 cathode for sodium ion batteries
EP3600262A4 (en) 2017-03-24 2020-09-16 E Ink California, LLC Microcell delivery systems including charged or magnetic particles for regulating rate of administration of actives
WO2018175825A1 (en) 2017-03-24 2018-09-27 E Ink California, Llc Microcell systems for delivering active molecules
TWI682787B (en) 2017-11-14 2020-01-21 美商伊英克加利福尼亞有限責任公司 Electrophoretic active delivery system including porous conductive electrode layer
JP2022511336A (en) * 2018-09-20 2022-01-31 シンガポール ヘルス サービシーズ ピーティーイー リミテッド Conductive microneedle patch for activator delivery
KR20220074962A (en) 2019-11-27 2022-06-03 이 잉크 캘리포니아 엘엘씨 Benefit agent delivery system comprising microcells having an electro-erodible sealing layer
CN116322881A (en) 2020-10-29 2023-06-23 伊英克加利福尼亚有限责任公司 Microcell systems for delivering benefit agents
EP4236927A1 (en) 2020-10-29 2023-09-06 E Ink California, LLC Microcell systems for delivering hydrophilic active molecules

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE399044A (en) * 1933-09-09
US2784715A (en) * 1953-03-25 1957-03-12 Kestler Otto Colman Cataphoresis unit
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
US3677268A (en) * 1969-11-28 1972-07-18 Sherwood Medical Ind Inc Iontophoresis electrode
US3716054A (en) * 1970-08-11 1973-02-13 W Porter Apparatus for applying medication to teeth and body tissue
US3677288A (en) * 1970-10-08 1972-07-18 Thomas B Martin Flow control valve
US3794910A (en) * 1971-07-26 1974-02-26 Sherwood Medical Ind Inc Iontophoresis and conductivity analysis circuit
US4019510A (en) * 1975-02-10 1977-04-26 Sybron Corporation Therapeutic method of using low intensity direct current generator with polarity reversal
US4767401A (en) * 1975-04-22 1988-08-30 Maurice Seiderman Iontophoretic administration of ionizable or polar medicaments to a mammalian body
DE2626348C3 (en) * 1976-06-11 1980-01-31 Siemens Ag, 1000 Berlin Und 8000 Muenchen Implantable dosing device
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4166457A (en) * 1976-08-16 1979-09-04 University Of Utah Research Institute Fluid self-sealing bioelectrode
US4211222A (en) * 1976-08-25 1980-07-08 Robert Tapper Iontophoretic burn-protection method
US4325367A (en) * 1977-06-13 1982-04-20 Robert Tapper Iontophoretic treatment apparatus
GB2030453B (en) * 1978-10-03 1983-05-05 Tapper R Applying unidirectional elecric current to the skin of a living body
US4301794A (en) * 1978-10-18 1981-11-24 Robert Tapper Method for iontophoretic treatment
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4633879A (en) * 1979-11-16 1987-01-06 Lec Tec Corporation Electrode with disposable interface member
US4383529A (en) * 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4419091A (en) * 1981-02-12 1983-12-06 Sybron Corporation Metalized medical treatment electrode with insulated edge
US4416274A (en) * 1981-02-23 1983-11-22 Motion Control, Inc. Ion mobility limiting iontophoretic bioelectrode
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
JPS5810066A (en) * 1981-07-10 1983-01-20 株式会社アドバンス Plaster structure for ion tofuorese
US4477971A (en) * 1981-11-06 1984-10-23 Motion Control, Inc. Iontophoretic electrode structure
HU185691B (en) * 1982-02-09 1985-03-28 Richter Gedeon Vegyeszet Process for preparing a new analgetic pharmaceutical composition
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4557723A (en) * 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
US4883457A (en) * 1983-08-18 1989-11-28 Drug Delivery Systems Inc. Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4808152A (en) * 1983-08-18 1989-02-28 Drug Delivery Systems Inc. System and method for controlling rate of electrokinetic delivery of a drug
US4640689A (en) * 1983-08-18 1987-02-03 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
CA1262564A (en) * 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
US5135477A (en) * 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4744787A (en) * 1984-10-29 1988-05-17 Medtronic, Inc. Iontophoresis apparatus and methods of producing same
US4747819A (en) * 1984-10-29 1988-05-31 Medtronic, Inc. Iontophoretic drug delivery
US4702732A (en) * 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
GB8509978D0 (en) * 1985-04-18 1985-05-30 Juhasz L Wound dressings
EP0225871B1 (en) * 1985-06-10 1990-03-14 Drug Delivery Systems Inc. System and method for controlling rate of electrokinetic delivery of a drug
JPS6222662A (en) * 1985-07-19 1987-01-30 林原　健 Ion introducing electronic treatment device
JPS62159661A (en) * 1985-12-31 1987-07-15 林原　健 Low frequency remedy device for introducing both positive and negative ions
US4717581A (en) * 1986-02-06 1988-01-05 Eic Laboratories, Inc. Iridium oxide coated electrodes for neural stimulation
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US4679572A (en) * 1986-03-11 1987-07-14 Intermedics, Inc. Low threshold cardiac pacing electrodes
AU597890B2 (en) * 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4752285B1 (en) * 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
US4915685A (en) * 1986-03-19 1990-04-10 Petelenz Tomasz J Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange
US4886489A (en) * 1986-03-19 1989-12-12 Jacobsen Stephen C Flow-through methods and apparatus for iontophoresis application of medicaments at a controlled pH
US4734090A (en) * 1986-07-18 1988-03-29 Drug Delivery Systems Inc. Electrical transdermal drug applicator
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4725263A (en) * 1986-07-31 1988-02-16 Medtronic, Inc. Programmable constant current source transdermal drug delivery system
JPS63102768A (en) * 1986-10-20 1988-05-07 山之内製薬株式会社 Novel plaster structure for iontophoresis
US4786277A (en) * 1986-11-21 1988-11-22 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation
US4822334A (en) * 1986-12-04 1989-04-18 Robert Tapper Electrical dosimetry control system
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
WO1988008729A1 (en) * 1987-05-15 1988-11-17 Newman Martin H Iontophoresis drug delivery system
AU615188B2 (en) * 1987-05-28 1991-09-26 Drug Delivery Systems Inc. Pulsating transdermal drug delivery system
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
JPS6456060A (en) * 1987-08-27 1989-03-02 Hayashibara Takeshi Low frequency medical treatment device
EP0318776A1 (en) * 1987-12-04 1989-06-07 Robert Tapper Method and apparatus for minimizing skin injury with electrode use
IL86076A (en) * 1988-04-14 1992-12-01 Inventor S Funding Corp Ltd Transdermal drug delivery device
US4973303A (en) * 1989-09-05 1990-11-27 Empi, Inc. pH buffered electrode for medical iontophoresis
US5334138A (en) * 1990-03-15 1994-08-02 North Carolina State University Method and composition for increased skin concentration of active agents by iontophoresis
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US5246417A (en) * 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6330471B1 (en) 1996-03-17 2001-12-11 Hisamitsu Pharmaceutical Co., Ltd. Iontophoresis electrode device

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US5443442A (en) 1995-08-22
US5125894A (en) 1992-06-30
CA2129242C (en) 2001-12-25
JPH07502905A (en) 1995-03-30
WO1993014813A1 (en) 1993-08-05
EP0625061B1 (en) 1997-03-26
DE69218629D1 (en) 1997-04-30
US5591124A (en) 1997-01-07
EP0625061A1 (en) 1994-11-23
DE69218629T2 (en) 1997-07-31
US5622530A (en) 1997-04-22
JP3368322B2 (en) 2003-01-20
AU1359392A (en) 1993-09-01

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