CA2127870C - Composition for desensitizing teeth - Google Patents
Composition for desensitizing teethInfo
- Publication number
- CA2127870C CA2127870C CA002127870A CA2127870A CA2127870C CA 2127870 C CA2127870 C CA 2127870C CA 002127870 A CA002127870 A CA 002127870A CA 2127870 A CA2127870 A CA 2127870A CA 2127870 C CA2127870 C CA 2127870C
- Authority
- CA
- Canada
- Prior art keywords
- particles
- composition according
- tooth
- composition
- teeth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 17
- 239000002245 particle Substances 0.000 claims abstract description 35
- 206010020751 Hypersensitivity Diseases 0.000 claims abstract description 9
- 239000004793 Polystyrene Substances 0.000 claims abstract description 3
- 229920002223 polystyrene Polymers 0.000 claims abstract description 3
- 238000000586 desensitisation Methods 0.000 claims abstract 2
- 239000006185 dispersion Substances 0.000 claims description 9
- 239000004005 microsphere Substances 0.000 claims description 7
- 230000000845 anti-microbial effect Effects 0.000 claims description 4
- 239000004599 antimicrobial Substances 0.000 claims description 4
- 239000000551 dentifrice Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 210000005239 tubule Anatomy 0.000 abstract description 15
- 210000004268 dentin Anatomy 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 4
- 239000011859 microparticle Substances 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 description 3
- 239000002324 mouth wash Substances 0.000 description 3
- 229940051866 mouthwash Drugs 0.000 description 3
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- -1 alkali metal salts Chemical class 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241001535291 Analges Species 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 101100345589 Mus musculus Mical1 gene Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- VBIXEXWLHSRNKB-UHFFFAOYSA-N ammonium oxalate Chemical compound [NH4+].[NH4+].[O-]C(=O)C([O-])=O VBIXEXWLHSRNKB-UHFFFAOYSA-N 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229960002319 barbital Drugs 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 239000004075 cariostatic agent Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 201000005562 gingival recession Diseases 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/025—Explicitly spheroidal or spherical shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8117—Homopolymers or copolymers of aromatic olefines, e.g. polystyrene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/654—The particulate/core comprising macromolecular material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A composition for desensitizing a hypersensitive tooth, comprises an effective amount of charged polymeric particles in a preparation for application to the surface of said tooth to cause desensitization of said tooth. polystyrene microparticles may be used in the method in which the composition is applied to the tooth surface. The method may comprise applying to said surface a sufficient amount of charged polymeric particles to block exposed tubules in the dentin layer of the tooth.
Description
W093/13748 2 1 2 7 8 7 ~ PCT/US93/00239 .~ -- 1 --COMPOSITION FOR u~N~ITT~TNG ~
The invention relates to A-~ensitizing teeth.
The dentin layer in a tooth generally contains ch~nr~ or tubules, exte~A~g from the pulpal surface to the peripheral surface located interior to the enamel and cementum.
Exposure of these tubules in the dentin may occur through the loss of enamel and/or gingival recession accompanied by a 1088 of cementum. It has been theorized that these eYro~ tubules are in part recponsible for the hypersensitivity to external ~timuli, such as hot or cold fluids, or applied merh~nical p.e~ re~ often exhibited by teeth.
The problem of hypersensitive teeth is well-r~co~ized, and various treatment~ have been pl O~ : F ~~ in the art. Pashley et al., U.S.
Patent No. 4,057,021, describes Ar~ensitizing hypersensitive teeth by applying an aqueou~
solution of alkali metal salts and ammonium oxalate to the surface of the teeth. Kim, U.S.
Patent Nos. 4,631,185 and 4,751,072, de~cribe desensitizing teeth by treatment with potassium salts. Neirinckx, U.S. 4,990,327, describes desensitizing teeth with strontium ion and fluoride ion. Mason, U.S. 4,992,258, describes WO93/13748 ~ ~ PCT/US93/00239 desensitizing teeth by applying a dentifrice ineluding a montmorillonite clay. Lutz, U.S.
Pat. No. 4,011,309, deseribes a desensitizing dentifriee eomposition that includes eitric acid, sodium citrate, and non-ionic polyol surfaetant. Mlkvy et al., U.S. Patent Nos.
The invention relates to A-~ensitizing teeth.
The dentin layer in a tooth generally contains ch~nr~ or tubules, exte~A~g from the pulpal surface to the peripheral surface located interior to the enamel and cementum.
Exposure of these tubules in the dentin may occur through the loss of enamel and/or gingival recession accompanied by a 1088 of cementum. It has been theorized that these eYro~ tubules are in part recponsible for the hypersensitivity to external ~timuli, such as hot or cold fluids, or applied merh~nical p.e~ re~ often exhibited by teeth.
The problem of hypersensitive teeth is well-r~co~ized, and various treatment~ have been pl O~ : F ~~ in the art. Pashley et al., U.S.
Patent No. 4,057,021, describes Ar~ensitizing hypersensitive teeth by applying an aqueou~
solution of alkali metal salts and ammonium oxalate to the surface of the teeth. Kim, U.S.
Patent Nos. 4,631,185 and 4,751,072, de~cribe desensitizing teeth by treatment with potassium salts. Neirinckx, U.S. 4,990,327, describes desensitizing teeth with strontium ion and fluoride ion. Mason, U.S. 4,992,258, describes WO93/13748 ~ ~ PCT/US93/00239 desensitizing teeth by applying a dentifrice ineluding a montmorillonite clay. Lutz, U.S.
Pat. No. 4,011,309, deseribes a desensitizing dentifriee eomposition that includes eitric acid, sodium citrate, and non-ionic polyol surfaetant. Mlkvy et al., U.S. Patent Nos.
3,888,976 and 3,772,431 deseribe using a zine or ~L-o--Lium ion containing astringent-~esencitizing agent in an efferveseent mouthwash tablet. Hodosh, U.S. Patent No. 3,863,006, deseribes desensitizing teeth with a nitrate salt. Svajda, U.S. Patent No. 3,689,636, deseribes desensitizing teeth with solutions of ehloride salts. Ro~enthal, U.S. Patent No.
3,122,483, deseribes ~e~?n~itizing teeth with strontium ions. Seheller, U.S. Patent Nos.
3,122,483, deseribes ~e~?n~itizing teeth with strontium ions. Seheller, U.S. Patent Nos.
4,634,589 and 4,710,372, deseribe a dentifriee eont~ini~g apatite partieles for treating hypersensitive teeth.
It is known that dentifriees may inelude partieles whieh thieken or eolor the dentifriee, or whieh make the dentifriee abrasive. For example, in Sch~ller '589 and '372, the apatite partieles are ineluded in the dentifriee to roughen the surfaee of the teeth.
See al~o, Thuersson et al., U.S. Patent No.
3,226,297 (e.g., eol. 4, lines 34-43); 81unt, U.S. Patent No. 3,475,369 (e.g., col. 12, lines 27-34); Patino et al., U.S. Patent No. 4,007,259 (e.g. eol. 1, line 30); R~Q~-rd, U.S. Patent No.
2,994,642 (e.g., eol. 4, line~ 40-60); La Follette, U.S. Patent No. 3,357,950 (e.g., eol.
1, lines 50-61); Adams, U.S. Patent No.
3,357,951 (e.g., eol. 1, lines 49-61); Muhler, U.S. Patent No. 3,450,813; Watson, U.S. Patent No. 3,934,001; Naum~nn et al., U.S. Patent No.
3,978,206 (e.g., eol. 1, lines 39-57); Davis, U.S. Patent No. 4,102,992; and Humphries et al., U.S. Patent No. 4,963,347.
Jernberq, U.S. Patent No. 4,685,883, describes using biodegradable microspheres to deliver chemotherapeutic agents to lesions in the gums.
Dichter et al., U.S. Patent No.
3,956,480 describes treating teeth with anionic polymers complexed with a cationic germicide, such as chlorh~Yi~ine.
According to the invention there is provided a composition for desensitizing a hypersensitive tooth, comprising an effective amount of charged polymeric particles.
The preferred particle~ have ! an averagQ size of bQtween 0.01 micron to 3 microns, more preferably between 0.2 micron to 0.6 micron, and an average surface charge density of greater than 4 ~C/cm2. The more preferred particles are microspheres, such a~
the polystyrene microspheres. The more A
2 1 27~ 7U
preferred particles, optionally, may have an antimicrobial (e.g., chlorhexidine) an analgesic compound (e.g. barbital), or other therapeutic substance (e.g. anti-calculus agent or anti-caries agent), adsorbed on their surface. In apreferred method, the surface of the hypersensitive tooth i8 polished, and a dispersion of the particles is applied to the polished surface for at lea~t one minute. A
preferred method of applying the particles is by brushing the teeth with a toothbrush having bristles which include the particles.
In another a~pect, the invention features a dentifrice including charged polymeric microspheres.
The invention provide~ an effective, straightforward way to desensitize teeth.
Without being bound to any theory, it is believed that the invention is effective at least in part because the charged particles cling to the surface of the teeth, blocking the tubules, and making it more difficult for - external stimuli like hot or cold temperatures to affect the nerve in the pulp. When some of the particles blocking the tubules eventually wash out of the tubules, they are easily replenished by an additional application of particles.
Other features and advantages of the invention will be apparent from the description of the preferred embodiment thereof, and from the claims.
Fig. 1 i~ an electron mi~ .aph of a A
W O 93/13748 2 1 ~ 7 8 7 0 PC~r/US93/00239 ~_ --5--dentin surface prior to exposure to the particles of the invention.
Fig. 2 is an ele--L~u~. mi~lo~ r aph of ~ the surface of Fig. 1 after exposure to the particles of the invention.
The charged particles preferably have an average diameter of less than 0.6 micron.
Larger particles may not fit as well in the dentin tubules.
The more preferred particles are positively charged poly~y.ene mi~ G_~l.eres having an average diameter of about 0.5 micron.
The mi~r~s~heres were supplied by Interfacial Dynamics Corp. of Portland, O~e~u,. (Catalog No.
10-43-57). It is believed that to provide the benefits of the invention a sufficient quantity of charged particles should be applied to the surface of a hypersensitive region of the tooth 80 that the charged particles clog the eYro~~l tubules in the dentin. This application can be performed in a variety of ways; for example, the tooth surface can be wa~hed with a ron~ntrated aqueous ~icrersion of the particles. Generally, the more co~..Llated the dispersion of particles, the less time the surface of the tooth needs to be wa~h~. The following are examples of typical ~L O~ re~ that can be used to apply the particles.
The tooth surface initially i~
polished. The surface i~ then ~ e~ to an aqueous dispersion of the more preferred J microsrh~reB (1.6 X 101~ particles/ml, pH 4). A
preferred dispersion is formed by diluting 916 ~l of the preferred mi~.o_~l,ere ~cp~rsion (Catalog No. 10-43-57, Interfacial Dynamics) to a volume of 40 ml with water which has been filtered, double distilled, and adjusted to pH
W O 93/13748 P~r/US93/00239 212~870 4. The dispersion is then agitated against the tooth surface for S minutes. Alternatively, the surface is eYposed to a pressurized jet of the aqueous Ai~rsrsion e.g., at a pressure of about 30 psi for about 20 seconA~, or the surface is brushed with bristles that are saturated with mi~Lo-~heres, for 3 minutes. Each of these PLO~e~1U~ es, when performed on a tooth that had been removed from the mouth, wafi effective at blo~i ng the e~ro~~A tubules in the dentin of the tooth with the microcrh~rec~ as confirmed by sc~nn; ng electron mi~ ~~ope. Figs 1 and 2 show the dentin surface, before and after, respectively, a 5 minute e~v_u~e to a latex particle dispersion of 0.489 ~m positively charged poly_~y.~ne microspheres. Prior to e to the dispersion, the ~Yro-~ tubules in the dentin are empty; after ~o,- .e they are substantially filled with the particles ~r~-?nt in the Ai~r~rsion. (Fig~. 1 and 2 were both taken at 5000x magnification.) An alternative p~G~ e for applying the particle~ to the tooth is to soak a cotton pellet with an A~l~ dispersion of the particle~, and then rub the cotton pellet over the polished surface of the tooth, preferably for one minute or less.
Other emhoA;ment~ are within the claim~. For example, other types of charged micro~pherea can be u~ed in place of the poly~y.ene mi~ sre~. Moreover, the mi~lu_~heres can be included in a dentifrice (toothpa~te) or a mouthwash; when the dentifrice or mouthwa~h contact~ the ~urface of a tooth the mi~u_~heres will fill in the tubule~. This approach can be uced, in particular, to replenish microcr~res that were previously W O 93/13748 ~ 1 2 7 ~ 7 0 P~r/US93/00239 , "_ _ 7 blocking a tubule but have, to some extent, washed out of the tubule over time. If a mouthwash is used, it may be applied under pressure, using any commercially available water-jet applianee. The mi~lo_~heres can also be applied, for example, by including them on the bristles of toothbrushes or on dental floss.
While the times, p~ res and other conditions given above were preferred in a laboratory lo setting, these conditions may be varied as desired to adapt them to a clinical sQtting, provided the time, pres~ure etc., is adequate to block the tubules. Effective conditions may be readily determined by those skilled in the art, e.g. by determining whether a patient's tooth is still sensitive after the treatment.
In addition, the partiele~ may have an antimicrobial, analge~ie or other therapeutic substanee aA~Q~ed on their surfaee. The~e partieles provide both a ~ n~itization benefit of this invention and an anti-microbial benefit or other benefit provided by the therapeutic agent selected.
It is known that dentifriees may inelude partieles whieh thieken or eolor the dentifriee, or whieh make the dentifriee abrasive. For example, in Sch~ller '589 and '372, the apatite partieles are ineluded in the dentifriee to roughen the surfaee of the teeth.
See al~o, Thuersson et al., U.S. Patent No.
3,226,297 (e.g., eol. 4, lines 34-43); 81unt, U.S. Patent No. 3,475,369 (e.g., col. 12, lines 27-34); Patino et al., U.S. Patent No. 4,007,259 (e.g. eol. 1, line 30); R~Q~-rd, U.S. Patent No.
2,994,642 (e.g., eol. 4, line~ 40-60); La Follette, U.S. Patent No. 3,357,950 (e.g., eol.
1, lines 50-61); Adams, U.S. Patent No.
3,357,951 (e.g., eol. 1, lines 49-61); Muhler, U.S. Patent No. 3,450,813; Watson, U.S. Patent No. 3,934,001; Naum~nn et al., U.S. Patent No.
3,978,206 (e.g., eol. 1, lines 39-57); Davis, U.S. Patent No. 4,102,992; and Humphries et al., U.S. Patent No. 4,963,347.
Jernberq, U.S. Patent No. 4,685,883, describes using biodegradable microspheres to deliver chemotherapeutic agents to lesions in the gums.
Dichter et al., U.S. Patent No.
3,956,480 describes treating teeth with anionic polymers complexed with a cationic germicide, such as chlorh~Yi~ine.
According to the invention there is provided a composition for desensitizing a hypersensitive tooth, comprising an effective amount of charged polymeric particles.
The preferred particle~ have ! an averagQ size of bQtween 0.01 micron to 3 microns, more preferably between 0.2 micron to 0.6 micron, and an average surface charge density of greater than 4 ~C/cm2. The more preferred particles are microspheres, such a~
the polystyrene microspheres. The more A
2 1 27~ 7U
preferred particles, optionally, may have an antimicrobial (e.g., chlorhexidine) an analgesic compound (e.g. barbital), or other therapeutic substance (e.g. anti-calculus agent or anti-caries agent), adsorbed on their surface. In apreferred method, the surface of the hypersensitive tooth i8 polished, and a dispersion of the particles is applied to the polished surface for at lea~t one minute. A
preferred method of applying the particles is by brushing the teeth with a toothbrush having bristles which include the particles.
In another a~pect, the invention features a dentifrice including charged polymeric microspheres.
The invention provide~ an effective, straightforward way to desensitize teeth.
Without being bound to any theory, it is believed that the invention is effective at least in part because the charged particles cling to the surface of the teeth, blocking the tubules, and making it more difficult for - external stimuli like hot or cold temperatures to affect the nerve in the pulp. When some of the particles blocking the tubules eventually wash out of the tubules, they are easily replenished by an additional application of particles.
Other features and advantages of the invention will be apparent from the description of the preferred embodiment thereof, and from the claims.
Fig. 1 i~ an electron mi~ .aph of a A
W O 93/13748 2 1 ~ 7 8 7 0 PC~r/US93/00239 ~_ --5--dentin surface prior to exposure to the particles of the invention.
Fig. 2 is an ele--L~u~. mi~lo~ r aph of ~ the surface of Fig. 1 after exposure to the particles of the invention.
The charged particles preferably have an average diameter of less than 0.6 micron.
Larger particles may not fit as well in the dentin tubules.
The more preferred particles are positively charged poly~y.ene mi~ G_~l.eres having an average diameter of about 0.5 micron.
The mi~r~s~heres were supplied by Interfacial Dynamics Corp. of Portland, O~e~u,. (Catalog No.
10-43-57). It is believed that to provide the benefits of the invention a sufficient quantity of charged particles should be applied to the surface of a hypersensitive region of the tooth 80 that the charged particles clog the eYro~~l tubules in the dentin. This application can be performed in a variety of ways; for example, the tooth surface can be wa~hed with a ron~ntrated aqueous ~icrersion of the particles. Generally, the more co~..Llated the dispersion of particles, the less time the surface of the tooth needs to be wa~h~. The following are examples of typical ~L O~ re~ that can be used to apply the particles.
The tooth surface initially i~
polished. The surface i~ then ~ e~ to an aqueous dispersion of the more preferred J microsrh~reB (1.6 X 101~ particles/ml, pH 4). A
preferred dispersion is formed by diluting 916 ~l of the preferred mi~.o_~l,ere ~cp~rsion (Catalog No. 10-43-57, Interfacial Dynamics) to a volume of 40 ml with water which has been filtered, double distilled, and adjusted to pH
W O 93/13748 P~r/US93/00239 212~870 4. The dispersion is then agitated against the tooth surface for S minutes. Alternatively, the surface is eYposed to a pressurized jet of the aqueous Ai~rsrsion e.g., at a pressure of about 30 psi for about 20 seconA~, or the surface is brushed with bristles that are saturated with mi~Lo-~heres, for 3 minutes. Each of these PLO~e~1U~ es, when performed on a tooth that had been removed from the mouth, wafi effective at blo~i ng the e~ro~~A tubules in the dentin of the tooth with the microcrh~rec~ as confirmed by sc~nn; ng electron mi~ ~~ope. Figs 1 and 2 show the dentin surface, before and after, respectively, a 5 minute e~v_u~e to a latex particle dispersion of 0.489 ~m positively charged poly_~y.~ne microspheres. Prior to e to the dispersion, the ~Yro-~ tubules in the dentin are empty; after ~o,- .e they are substantially filled with the particles ~r~-?nt in the Ai~r~rsion. (Fig~. 1 and 2 were both taken at 5000x magnification.) An alternative p~G~ e for applying the particle~ to the tooth is to soak a cotton pellet with an A~l~ dispersion of the particle~, and then rub the cotton pellet over the polished surface of the tooth, preferably for one minute or less.
Other emhoA;ment~ are within the claim~. For example, other types of charged micro~pherea can be u~ed in place of the poly~y.ene mi~ sre~. Moreover, the mi~lu_~heres can be included in a dentifrice (toothpa~te) or a mouthwash; when the dentifrice or mouthwa~h contact~ the ~urface of a tooth the mi~u_~heres will fill in the tubule~. This approach can be uced, in particular, to replenish microcr~res that were previously W O 93/13748 ~ 1 2 7 ~ 7 0 P~r/US93/00239 , "_ _ 7 blocking a tubule but have, to some extent, washed out of the tubule over time. If a mouthwash is used, it may be applied under pressure, using any commercially available water-jet applianee. The mi~lo_~heres can also be applied, for example, by including them on the bristles of toothbrushes or on dental floss.
While the times, p~ res and other conditions given above were preferred in a laboratory lo setting, these conditions may be varied as desired to adapt them to a clinical sQtting, provided the time, pres~ure etc., is adequate to block the tubules. Effective conditions may be readily determined by those skilled in the art, e.g. by determining whether a patient's tooth is still sensitive after the treatment.
In addition, the partiele~ may have an antimicrobial, analge~ie or other therapeutic substanee aA~Q~ed on their surfaee. The~e partieles provide both a ~ n~itization benefit of this invention and an anti-microbial benefit or other benefit provided by the therapeutic agent selected.
Claims (12)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A composition for desensitizing a hypersensitive tooth, comprising an effective amount of charged polymeric particles in a preparation for application to the surface of said tooth to cause desensitization of said tooth.
2. A composition according to claim 1, wherein said particles have an average diameter of 0.01 micron to 3 microns.
3. A composition according to claim 2, wherein said particles have an average diameter of 0.2 micron to 0.6 micron.
4. A composition according to claim 1, wherein said particles have an average surface charge density of greater than 4 µC/cm2.
5. A composition according to claim 2, wherein said particles are microspheres.
6. A composition according to claim 5, wherein said microspheres comprise polystyrene.
7. A composition according to claim 1, wherein said particles are positively charged.
8. A composition according to claim 1, wherein said particles comprise a therapeutic agent adsorbed on their surface.
9. A composition according to claim 8, wherein said therapeutic agent comprises an antimicrobial.
10. A composition according to claim 8, wherein said therapeutic agent comprises an analgesic.
11. A composition according to claim 1, wherein said particles are in the form of an aqueous dispersion.
12. A composition according to any one of claims 1 to 10, comprising a dentifrice.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US820,348 | 1992-01-14 | ||
| US07/820,348 US5211939A (en) | 1991-09-13 | 1992-01-14 | Method for desensitizing teeth |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2127870A1 CA2127870A1 (en) | 1993-07-22 |
| CA2127870C true CA2127870C (en) | 1998-10-13 |
Family
ID=25230541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002127870A Expired - Fee Related CA2127870C (en) | 1992-01-14 | 1993-01-12 | Composition for desensitizing teeth |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5211939A (en) |
| EP (1) | EP0726756B1 (en) |
| CN (1) | CN1049112C (en) |
| AU (1) | AU3469493A (en) |
| CA (1) | CA2127870C (en) |
| DE (1) | DE69332835T2 (en) |
| MX (1) | MX9300160A (en) |
| WO (1) | WO1993013748A1 (en) |
| ZA (1) | ZA93196B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993005680A1 (en) * | 1991-09-13 | 1993-04-01 | Gillette Canada Inc. | Polymeric particles for dental applications |
| US5374417A (en) * | 1991-10-17 | 1994-12-20 | Colgate Palmolive Company | Desensitizing dentifrice |
| US5270031A (en) * | 1991-12-20 | 1993-12-14 | Block Drug Company Inc. | Dentinal desensitizing compositions |
| US5616315A (en) * | 1994-10-13 | 1997-04-01 | Gillette Canada Inc. | Particles including degradable material and anti-microbial agent |
| US5660817A (en) * | 1994-11-09 | 1997-08-26 | Gillette Canada, Inc. | Desensitizing teeth with degradable particles |
| CA2165013C (en) * | 1994-12-13 | 2004-01-06 | Nobuo Nakabayashi | Dental composition for relieving dentin hypersensitivity |
| US5589159A (en) * | 1995-04-11 | 1996-12-31 | Block Drug Company Inc. | Dispersible particulate system for desensitizing teeth |
| US5941256A (en) * | 1996-12-24 | 1999-08-24 | Gillette Canada Inc. | Dental hygiene article |
| US5937874A (en) * | 1997-06-03 | 1999-08-17 | Gillette Canada Inc. | Dental floss having two components which react to form an active agent |
| CN1063940C (en) * | 1997-06-25 | 2001-04-04 | 李健 | Box containing painting medicine for preventing decayed teeth and tooth desensitizing |
| US6096292A (en) * | 1998-07-28 | 2000-08-01 | Block Drug Company, Inc. | Polymeric desensitizing compositions |
| US6241972B1 (en) | 1999-02-19 | 2001-06-05 | Block Drug Company, Inc. | Oral care formulation for the treatment of sensitivity teeth |
| EP1731132B1 (en) | 2000-10-13 | 2008-12-10 | Block Drug Company, Inc. | Dental compositions for hypersensitive teeth |
| US6416745B1 (en) | 2001-05-03 | 2002-07-09 | Block Drug Company, Inc. | Dental composition for treating hypersensitive teeth |
| KR100797365B1 (en) * | 2001-09-27 | 2008-01-22 | 주식회사 엘지생활건강 | Oral composition for treating sensitive teeth |
| CN101299956A (en) * | 2004-07-02 | 2008-11-05 | 迪斯卡斯牙科有限责任公司 | Pull device |
| GB0912768D0 (en) * | 2009-07-22 | 2009-08-26 | Glaxo Group Ltd | Novel composition |
| WO2011063371A1 (en) * | 2009-11-23 | 2011-05-26 | University Of Medicine And Dentistry Of New Jersey | Dentinal drug delivery composition |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE21197E (en) * | 1939-09-05 | Tooth brush and process of making | ||
| US2558992A (en) * | 1951-07-03 | Colored nylon article and method | ||
| US2304478A (en) * | 1939-10-19 | 1942-12-08 | Rosenzweig Salo | Process of treating materials comprising albumin, such as hair, bristles and the like |
| US3226297A (en) * | 1954-03-31 | 1965-12-28 | Bofors Ab | Dentifrice compositions comprising polymethyl methacrylate abrasives |
| US2994642A (en) * | 1954-10-16 | 1961-08-01 | Bossard Francois Jean | Sodium chloride toothpaste having a silica aerogel carrier |
| US3122483A (en) * | 1960-07-21 | 1964-02-25 | Block Drug Co | Strontium ion toothpaste |
| US3380848A (en) * | 1964-05-27 | 1968-04-30 | Polymer Res Corp Of America | Method of producing solid polymeric material having bactericidal properties |
| US3258805A (en) * | 1964-11-04 | 1966-07-05 | Rossnan Michael | Tooth brush |
| US3357951A (en) * | 1965-06-17 | 1967-12-12 | Procter & Gamble | Process for making a resinous dentifrice cleaning agent |
| US3357950A (en) * | 1965-06-17 | 1967-12-12 | Procter & Gamble | Process for making a resinous dentifrice cleaning agent |
| US3934001A (en) * | 1965-12-07 | 1976-01-20 | Lever Brothers Company | Oral compositions containing germicidally active plastic powders |
| US3475369A (en) * | 1967-08-25 | 1969-10-28 | Hercules Inc | Colloidally dispersible alpha-olefin copolymers |
| US3450813A (en) * | 1967-10-06 | 1969-06-17 | Indiana University Foundation | Dentifrice compositions comprising zirconium silicate of particular particle size |
| DE1807299A1 (en) * | 1968-11-06 | 1970-06-04 | Bayer Ag | Dentifrices containing exchange resins, dental aids, tooth filling compounds, tooth varnishes and other products that come into contact with living teeth |
| US3542519A (en) * | 1969-02-18 | 1970-11-24 | Virginia R Teller | Toothbrush time-usage indicator |
| US3689636A (en) * | 1969-10-24 | 1972-09-05 | Bentex Pharm Co | Composition and method for desensitizing sensitive teeth |
| US3772431A (en) * | 1972-09-21 | 1973-11-13 | W Mlkvy | Effervescent mouthwash tablet |
| US3888976A (en) * | 1972-09-21 | 1975-06-10 | William P Mlkvy | Zinc and strontium ion containing effervescent mouthwash tablet |
| US3863006A (en) * | 1973-01-29 | 1975-01-28 | Milton Hodosh | Method for desensitizing teeth |
| US3957968A (en) * | 1973-08-20 | 1976-05-18 | Colgate-Palmolive Company | Dentifrices containing flat flakes of alpha-alumina |
| US4007259A (en) * | 1973-11-02 | 1977-02-08 | Colgate-Palmolive Company | Dental cream |
| US4102992A (en) * | 1974-02-08 | 1978-07-25 | Beecham Group Limited | Dentifrice |
| US3956480A (en) * | 1974-07-01 | 1976-05-11 | Colgate-Palmolive Company | Treatment of teeth |
| US3992336A (en) * | 1974-10-01 | 1976-11-16 | Union Carbide Corporation | Shaped article for conditioning hair fabricated from quaternary nitrogen-containing cellulose ether |
| US4018729A (en) * | 1974-10-01 | 1977-04-19 | Union Carbide Corporation | Shaped article for conditioning hair a blend of water-soluble and water-insoluble polymers with interpenetrating networks |
| US4011309A (en) * | 1975-01-20 | 1977-03-08 | Marion Laboratories, Inc. | Dentifrice composition and method for desensitizing sensitive teeth |
| US4138383A (en) * | 1975-11-24 | 1979-02-06 | California Institute Of Technology | Preparation of small bio-compatible microspheres |
| US4155870A (en) * | 1976-04-19 | 1979-05-22 | Minnesota Mining And Manufacturing Company | Skin cleaning compositions containing water-insoluble glass bubbles |
| US4057621A (en) * | 1976-05-24 | 1977-11-08 | Pashley David H | Desensitizing oxalate dental composition and method of treatment |
| JPS5933191B2 (en) * | 1979-07-31 | 1984-08-14 | 利男 杉田 | Film forming device |
| US4348378A (en) * | 1979-08-09 | 1982-09-07 | Kosti Carl M | Plaque disclosing dentifrice compositions with semi-solid microcapsules of dye |
| EP0038868B1 (en) * | 1980-04-29 | 1983-09-28 | Blendax-Werke R. Schneider GmbH & Co. | Toothpaste |
| US4678814A (en) * | 1981-03-30 | 1987-07-07 | California Institute Of Technology | Polyacrolein microspheres |
| DE3174347D1 (en) * | 1981-11-18 | 1986-05-15 | Trisa Buerstenfabrik Ag | Method of manufacturing brushes with bristles made of thermoplastics material, especially hair brushes, or bristle carriers for such brushes and brushes fabricated thereby |
| US5037818A (en) * | 1982-04-30 | 1991-08-06 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Washing composition for the hair |
| EP0095871A3 (en) * | 1982-05-27 | 1984-06-13 | Reckitt And Colman Products Limited | Improvements in or relating to tooth treatment compositions |
| US4685883A (en) * | 1983-09-12 | 1987-08-11 | Jernberg Gary R | Local delivery of chemotherapeutic agents for the treatment of periodontal disease |
| US4892736A (en) * | 1983-10-07 | 1990-01-09 | The Forsyth Dental Infirmary For Children | Intra-pocket drug delivery devices for treatment of periodontal diseases |
| US4631185A (en) * | 1984-03-13 | 1986-12-23 | The Trustees Of Columbia University In The City Of New York | Method of desensitizing hypersensitive dentin employing compositions containing potassium salts |
| US4634589A (en) * | 1984-05-18 | 1987-01-06 | Wurttembergische Parfumerie-Fabrik Gmbh | Dentifrice for hypersensitive teeth |
| GB8428523D0 (en) * | 1984-11-12 | 1984-12-19 | Ici Plc | Oral hygiene composition |
| DE3533533C1 (en) * | 1985-09-20 | 1986-09-04 | Blendax-Werke R. Schneider Gmbh & Co, 6500 Mainz | Method for rounding the bristle ends of toothbrushes |
| GB8527962D0 (en) * | 1985-11-13 | 1985-12-18 | Neirinckx R D | Desensitizing dental composition |
| GB8601100D0 (en) * | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
| JPS62240620A (en) * | 1986-04-10 | 1987-10-21 | Hidekazu Masuhara | Sedative for toothache containing n-methacryloyl-aminosalicylic acid |
| US4919939A (en) * | 1986-04-29 | 1990-04-24 | Pharmetrix Corporation | Periodontal disease treatment system |
| US4780320A (en) * | 1986-04-29 | 1988-10-25 | Pharmetrix Corp. | Controlled release drug delivery system for the periodontal pocket |
| US4867988A (en) * | 1987-04-08 | 1989-09-19 | Production Previews, Inc. | Dentifrice containing microencapsulated oxygen |
| US4802244A (en) * | 1987-08-28 | 1989-02-07 | Mcgrath Saleh Melissa | Premature infant bedding construction |
| JPH0725649B2 (en) * | 1987-10-12 | 1995-03-22 | 而至歯科工業株式会社 | Disinfectant-containing alginate impression material |
| US4978391A (en) * | 1987-11-13 | 1990-12-18 | Dentsply Management Corp. | Intraoral medicament delivery and procedure |
| US5061106A (en) * | 1988-03-08 | 1991-10-29 | Colgate-Palmolive Company | Toothbrush with slow release of disinfectant and antibacterial agents and method of manufacturing the same |
| US4986288A (en) * | 1988-03-23 | 1991-01-22 | Colgate-Palmolive Company | Dental floss and picks |
| JP2608131B2 (en) * | 1989-03-14 | 1997-05-07 | サンスター株式会社 | toothbrush |
| US4980150A (en) * | 1989-04-27 | 1990-12-25 | Zetachron, Inc. | Chlorhexidine complex |
| US5000941A (en) * | 1989-05-16 | 1991-03-19 | Milton P. Chernack | Dentifrice containing microencapsulated oxygen |
| US4992258A (en) * | 1989-10-23 | 1991-02-12 | Colgate-Palmolive Company | Dentrifice composition |
| IL94294A (en) * | 1990-05-04 | 1992-11-15 | Hamivreshet Brush Factory Kibb | Toothbrush |
| GB9021061D0 (en) * | 1990-09-27 | 1990-11-07 | Unilever Plc | Encapsulating method and products containing encapsulated material |
-
1992
- 1992-01-14 US US07/820,348 patent/US5211939A/en not_active Expired - Lifetime
-
1993
- 1993-01-12 ZA ZA93196A patent/ZA93196B/en unknown
- 1993-01-12 EP EP93903426A patent/EP0726756B1/en not_active Expired - Lifetime
- 1993-01-12 DE DE69332835T patent/DE69332835T2/en not_active Expired - Fee Related
- 1993-01-12 CA CA002127870A patent/CA2127870C/en not_active Expired - Fee Related
- 1993-01-12 AU AU34694/93A patent/AU3469493A/en not_active Abandoned
- 1993-01-12 WO PCT/US1993/000239 patent/WO1993013748A1/en active IP Right Grant
- 1993-01-13 MX MX9300160A patent/MX9300160A/en not_active Application Discontinuation
- 1993-01-14 CN CN93101735A patent/CN1049112C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU3469493A (en) | 1993-08-03 |
| ZA93196B (en) | 1993-08-11 |
| DE69332835T2 (en) | 2003-12-11 |
| DE69332835D1 (en) | 2003-05-08 |
| EP0726756B1 (en) | 2003-04-02 |
| CN1077626A (en) | 1993-10-27 |
| WO1993013748A1 (en) | 1993-07-22 |
| CA2127870A1 (en) | 1993-07-22 |
| EP0726756A1 (en) | 1996-08-21 |
| CN1049112C (en) | 2000-02-09 |
| US5211939A (en) | 1993-05-18 |
| MX9300160A (en) | 1994-07-29 |
| EP0726756A4 (en) | 1996-09-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2127870C (en) | Composition for desensitizing teeth | |
| AU703580B2 (en) | Desensitizing teeth with degradable particles | |
| US5565206A (en) | Polymeric particles for dental applications | |
| EP0760647B1 (en) | Relief of dentinal hypersensitivity by submicron particles | |
| CA2778544C (en) | Dental care products with diamond particles | |
| JP2002540085A (en) | Treatment of dentin hypersensitivity using aqueous dispersion of hydrophobic / hydrophilic copolymer | |
| US5250288A (en) | Method for desensitizing teeth | |
| CA1306198C (en) | Cosmetic product | |
| Bonesvoll | Retention and plaque-inhibiting effect in man of chlorhexidine after multiple mouth rinses and retention and release of chlorhexidine after toothbrushing with a chlorhexidine gel | |
| CA1305067C (en) | Cosmetic product | |
| EP0755241A1 (en) | SnF 2? GEL OF IMPROVED STAND-UP | |
| WO2014151244A1 (en) | Compositions and methods for remineralizing tooth enamel using calcium phosphate nanoparticles | |
| DE60122367T2 (en) | DENTAL COMPOSITIONS FOR SENSITIVE TEETH | |
| WO2001058416A2 (en) | Toothpaste with dental agent and microbeads | |
| AU712142B2 (en) | Composition for desensitizing teeth | |
| DE3402805A1 (en) | ORAL CARE AGAINST CARIES AND TARTAR | |
| CA2706250C (en) | Formulation and method for treatment of teeth |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |