CA2125579A1 - Ulcer prevention treatment composition and method - Google Patents
Ulcer prevention treatment composition and methodInfo
- Publication number
- CA2125579A1 CA2125579A1 CA002125579A CA2125579A CA2125579A1 CA 2125579 A1 CA2125579 A1 CA 2125579A1 CA 002125579 A CA002125579 A CA 002125579A CA 2125579 A CA2125579 A CA 2125579A CA 2125579 A1 CA2125579 A1 CA 2125579A1
- Authority
- CA
- Canada
- Prior art keywords
- treatment composition
- prevention treatment
- ulcer prevention
- ulcer
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Abstract
Anti-ulcer compositions are disclosed having therapeutic agents dispersed in a soluble matrix formed by melt spinning the therapeutic agent with a carrier and hydrogel. Methods of treating ulcer-bearing tissue and preparing the matrix are also disclosed. One embodiment includes use of gastric irritating bio-affecting agents in which case the composition is preventative as well as therapeutic.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80859991A | 1991-12-17 | 1991-12-17 | |
US808,599 | 1991-12-17 | ||
PCT/US1992/010978 WO1993011750A1 (en) | 1991-12-17 | 1992-12-16 | Ulcer prevention and treatment composition and method |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2125579A1 true CA2125579A1 (en) | 1993-06-24 |
CA2125579C CA2125579C (en) | 2005-06-21 |
Family
ID=25199224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002125579A Expired - Fee Related CA2125579C (en) | 1991-12-17 | 1992-12-16 | Ulcer prevention treatment composition and method |
Country Status (9)
Country | Link |
---|---|
US (3) | US5622717A (en) |
EP (1) | EP0661966B1 (en) |
JP (1) | JP3802555B2 (en) |
AU (1) | AU3328193A (en) |
CA (1) | CA2125579C (en) |
DE (1) | DE69231281T2 (en) |
DK (1) | DK0661966T3 (en) |
PL (1) | PL170554B1 (en) |
WO (1) | WO1993011750A1 (en) |
Families Citing this family (111)
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-
1992
- 1992-12-16 JP JP51118893A patent/JP3802555B2/en not_active Expired - Fee Related
- 1992-12-16 AU AU33281/93A patent/AU3328193A/en not_active Abandoned
- 1992-12-16 WO PCT/US1992/010978 patent/WO1993011750A1/en active IP Right Grant
- 1992-12-16 US US08/081,336 patent/US5622717A/en not_active Expired - Lifetime
- 1992-12-16 DK DK93901178T patent/DK0661966T3/en active
- 1992-12-16 CA CA002125579A patent/CA2125579C/en not_active Expired - Fee Related
- 1992-12-16 DE DE69231281T patent/DE69231281T2/en not_active Expired - Lifetime
- 1992-12-16 EP EP93901178A patent/EP0661966B1/en not_active Expired - Lifetime
- 1992-12-16 PL PL92303633A patent/PL170554B1/en unknown
-
1993
- 1993-08-27 US US08/113,485 patent/US5651987A/en not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/465,974 patent/US5811123A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5811123A (en) | 1998-09-22 |
JP3802555B2 (en) | 2006-07-26 |
CA2125579C (en) | 2005-06-21 |
DE69231281D1 (en) | 2000-08-24 |
EP0661966B1 (en) | 2000-07-19 |
DK0661966T3 (en) | 2000-10-16 |
AU3328193A (en) | 1993-07-19 |
US5622717A (en) | 1997-04-22 |
US5651987A (en) | 1997-07-29 |
JPH07502276A (en) | 1995-03-09 |
WO1993011750A1 (en) | 1993-06-24 |
DE69231281T2 (en) | 2001-03-01 |
PL170554B1 (en) | 1996-12-31 |
EP0661966A1 (en) | 1995-07-12 |
EP0661966A4 (en) | 1996-02-28 |
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Legal Events
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EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20121217 |