CA2125408A1 - Drug formulations for parenteral use - Google Patents

Drug formulations for parenteral use

Info

Publication number
CA2125408A1
CA2125408A1 CA002125408A CA2125408A CA2125408A1 CA 2125408 A1 CA2125408 A1 CA 2125408A1 CA 002125408 A CA002125408 A CA 002125408A CA 2125408 A CA2125408 A CA 2125408A CA 2125408 A1 CA2125408 A1 CA 2125408A1
Authority
CA
Canada
Prior art keywords
toremifene
desmethyltamoxifen
tamoxifen
complex
parenteral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002125408A
Other languages
French (fr)
Other versions
CA2125408C (en
Inventor
Harry Gosta Jalonen
Terttu Marita Heikkila
Hannu Uolevi Jalonen
Lauri Veikko Matti Kangas
Risto Arvo Sakari Lammintausta
Kauko Oiva Antero Kurkela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Harry Gosta Jalonen
Terttu Marita Heikkila
Hannu Uolevi Jalonen
Lauri Veikko Matti Kangas
Risto Arvo Sakari Lammintausta
Kauko Oiva Antero Kurkela
Orion-Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harry Gosta Jalonen, Terttu Marita Heikkila, Hannu Uolevi Jalonen, Lauri Veikko Matti Kangas, Risto Arvo Sakari Lammintausta, Kauko Oiva Antero Kurkela, Orion-Yhtyma Oy filed Critical Harry Gosta Jalonen
Priority to CA002456970A priority Critical patent/CA2456970C/en
Publication of CA2125408A1 publication Critical patent/CA2125408A1/en
Application granted granted Critical
Publication of CA2125408C publication Critical patent/CA2125408C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

This invention relates to parenteral preparations of antiestrogens such as toremifene, desmethyl toremifene, tamoxifen or desmethyltamoxifen. The preparations can be emulsions, liposomes or aqueous solutions of cyclodextrin-drug complexes.
Particularly the invention relates to a parenteral drug formulation comprising a complex having a 2-hydroxypropyl cyclodextrin component and including an active drug substance selected from the group consisting of toremifene, desmethyl toremifene, tamoxifen and desmethyltamoxifen or a pharmaceutically acceptable non-toxic salt thereof, said complex being present either in an aqueous solution or emulsion or loaded into a liposome.
CA002125408A 1991-12-10 1992-12-10 Drug formulations for parenteral use Expired - Lifetime CA2125408C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002456970A CA2456970C (en) 1991-12-10 1992-12-10 Drug formulations for parenteral use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919126209A GB9126209D0 (en) 1991-12-10 1991-12-10 Drug formulations for parenteral use
GB9126209.7 1991-12-10
PCT/FI1992/000339 WO1993011757A1 (en) 1991-12-10 1992-12-10 Drug formulations for parenteral use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002456970A Division CA2456970C (en) 1991-12-10 1992-12-10 Drug formulations for parenteral use

Publications (2)

Publication Number Publication Date
CA2125408A1 true CA2125408A1 (en) 1993-06-23
CA2125408C CA2125408C (en) 2004-04-20

Family

ID=10706001

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002125408A Expired - Lifetime CA2125408C (en) 1991-12-10 1992-12-10 Drug formulations for parenteral use

Country Status (11)

Country Link
US (1) US5571534A (en)
EP (1) EP0616529B1 (en)
JP (1) JP3558344B2 (en)
AT (1) ATE149828T1 (en)
AU (1) AU667861B2 (en)
CA (1) CA2125408C (en)
DE (1) DE69218241T2 (en)
GB (1) GB9126209D0 (en)
NO (1) NO308578B1 (en)
WO (1) WO1993011757A1 (en)
ZA (1) ZA929592B (en)

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ATE214269T1 (en) * 1997-06-27 2002-03-15 Akzo Nobel Nv LIQUID MEDICINAL SOLUTION FOR ORAL APPLICATION
US6077871A (en) * 1997-11-26 2000-06-20 Pfizer Inc. Droloxifene pharmaceutical compositions
US20040176470A1 (en) * 1998-05-07 2004-09-09 Steiner Mitchell S. Method for treatment and chemoprevention of prostate cancer
US20040092602A1 (en) * 1998-05-07 2004-05-13 Steiner Mitchell S. Method for treatment and chemoprevention of prostate cancer
US6413533B1 (en) * 1998-05-07 2002-07-02 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
US6632447B1 (en) 1998-05-07 2003-10-14 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
US20030130316A1 (en) * 2000-03-20 2003-07-10 Steiner Mitchell S. Method for chemoprevention of prostate cancer
US6413534B1 (en) 1998-05-07 2002-07-02 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
DE1003496T1 (en) * 1998-05-07 2000-11-02 Univ Tennessee Res Corp Method of preventing prostate cancer
PT1135193E (en) * 1998-12-04 2003-01-31 Max Delbrueck Centrum AGENTS FOR THE TREATMENT OF TUMORS BASED ON LIPOSOMES AND COMPREHENDING TAMOXYPHEN
FI109332B (en) 1998-12-17 2002-07-15 Orion Yhtymae Oyj Soluble compositions of toremifene
FI982733A (en) 1998-12-17 2000-06-18 Orion Yhtymae Oyj Soluble compositions of triphenylethylene estrogens
US6303157B1 (en) 2000-05-31 2001-10-16 Kava Pharmaceuticals, Inc. Extracts of kava-kava
US20040029831A1 (en) * 2000-05-31 2004-02-12 Kava Pharmaceuticals, Inc. Extracts of kava-kava
US20080249183A1 (en) * 2001-11-29 2008-10-09 Steiner Mitchell S Treatment of androgen-deprivation induced osteoporosis
ATE418972T1 (en) 2001-11-29 2009-01-15 Gtx Inc PREVENTION AND TREATMENT OF OSTEOPOROSIS INDUCED BY ANDROGEN DEFICIENCY
US20050239747A1 (en) * 2004-04-21 2005-10-27 Pharmaceutical Industry Technology And Development Center Compositions and methods of enhanced transdermal delivery of steroid compounds and preparation methods
WO2006001035A2 (en) * 2004-06-28 2006-01-05 Lifecare Innovations Pvt. Ltd. Synergistic liposomal tamoxifen composition for topical application and method of preparing thereof.
US20060019989A1 (en) * 2004-07-21 2006-01-26 Steiner Mitchell S Compositions comprising 5-alpha reductase inhibitors and SERMs and methods of use thereof
US20160106717A1 (en) 2004-09-24 2016-04-21 Gen Pharma Holdings LLC Cai-based systems and methods for the localized treatment of uveitis
CA2581126A1 (en) 2004-09-24 2006-04-06 Rfe Pharma Llc Carboxy-amido-triazoles for the localized treatment of ocular diseases
US20060105045A1 (en) * 2004-11-08 2006-05-18 Buchanan Charles M Cyclodextrin solubilizers for liquid and semi-solid formulations
WO2006052922A2 (en) * 2004-11-08 2006-05-18 Eastman Chemical Company Pharmaceutical formulations of cyclodextrins and selective estrogen receptor modulator compounds
ES2401285T3 (en) 2004-12-16 2013-04-18 The Regents Of The University Of California Drugs with lung as target
US20060270641A1 (en) * 2005-05-31 2006-11-30 Steiner Mitchell S Method for chemoprevention of prostate cancer
WO2007005754A2 (en) * 2005-07-01 2007-01-11 Alza Corporation Liposomal delivery vehicle for hydrophobic drugs
US8998881B2 (en) 2005-08-10 2015-04-07 Alza Corporation Method for delivering drugs to tissue under microjet propulsion
WO2007078060A1 (en) * 2005-12-30 2007-07-12 Amorepacific Corporation Polymer-liposome nano-complexes and the preparation method thereof, and the composition of skin external application containing the same
EP2617423A1 (en) 2006-10-19 2013-07-24 Genzyme Corporation Purine derivatives for the treatment of cystic diseases
PE20120923A1 (en) 2009-03-30 2012-08-27 Eisai Randd Man Co Ltd PHARMACEUTICAL COMPOSITIONS INCLUDING LIPOSOMES CONTAINING ERIBULIN OR A SALT OF IT
JP5622719B2 (en) * 2009-03-30 2014-11-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 Method for producing liposome composition
NZ609420A (en) 2010-09-16 2015-06-26 Shimoda Biotech Pty Ltd Fulvestrant compositions and methods of use
WO2013008083A1 (en) 2011-07-13 2013-01-17 National Institute Of Pharmaceutical Education And Research (Niper) Pharmaceutical composition for enhancing anticancer efficacy of tamoxifen
MX346432B (en) 2011-09-18 2017-03-21 Euro-Celtique S A * Pharmaceutical compositions.
TWI573792B (en) 2012-02-01 2017-03-11 歐陸斯迪公司 Novel therapeutic agents
CN107056838A (en) 2013-03-15 2017-08-18 加利福尼亚大学董事会 Acyclic nucleoside phosphonate diester
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409485D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409488D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
HRP20220651T1 (en) 2014-09-15 2022-08-19 The Regents Of The University Of California Nucleotide analogs
CN105748442B (en) * 2016-04-07 2019-04-12 天津中医药大学 A kind of preparation method of rhodioside and double load medicine anti-breast cancer nanometer formulations of tamoxifen
DK3471722T3 (en) 2016-06-17 2023-12-04 Univ Pennsylvania Compounds, compositions and methods for preventing and/or treating cancer
WO2018068832A1 (en) 2016-10-11 2018-04-19 Euro-Celtique S.A. Hodgkin lymphoma therapy
GB201709403D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating sarcoma
GB201709406D0 (en) 2017-06-13 2017-07-26 Euro-Cletique S A Compounds for treating TNBC
GB201709402D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating t-pll
GB201709405D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating ovarian cancer
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Also Published As

Publication number Publication date
EP0616529B1 (en) 1997-03-12
AU3159993A (en) 1993-07-19
JP3558344B2 (en) 2004-08-25
NO308578B1 (en) 2000-10-02
NO942155D0 (en) 1994-06-09
ATE149828T1 (en) 1997-03-15
DE69218241T2 (en) 1997-06-19
GB9126209D0 (en) 1992-02-12
ZA929592B (en) 1993-08-06
AU667861B2 (en) 1996-04-18
NO942155L (en) 1994-06-10
CA2125408C (en) 2004-04-20
JPH07501813A (en) 1995-02-23
US5571534A (en) 1996-11-05
DE69218241D1 (en) 1997-04-17
EP0616529A1 (en) 1994-09-28
WO1993011757A1 (en) 1993-06-24

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20121210