CA2125027A1 - Stable Microbubble Suspensions as Enhancement Agents for Ultrasound Echography - Google Patents

Stable Microbubble Suspensions as Enhancement Agents for Ultrasound Echography

Info

Publication number
CA2125027A1
CA2125027A1 CA2125027A CA2125027A CA2125027A1 CA 2125027 A1 CA2125027 A1 CA 2125027A1 CA 2125027 A CA2125027 A CA 2125027A CA 2125027 A CA2125027 A CA 2125027A CA 2125027 A1 CA2125027 A1 CA 2125027A1
Authority
CA
Canada
Prior art keywords
suspensions
enhancement agents
microbubble suspensions
disclosed
ultrasound echography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2125027A
Other languages
French (fr)
Other versions
CA2125027C (en
Inventor
Michel Schneider
Jean Brochot
Jerome Puginier
Feng Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8212014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2125027(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2125027A1 publication Critical patent/CA2125027A1/en
Application granted granted Critical
Publication of CA2125027C publication Critical patent/CA2125027C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Surgical Instruments (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Aeration Devices For Treatment Of Activated Polluted Sludge (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Colloid Chemistry (AREA)
  • Physical Water Treatments (AREA)
  • Cosmetics (AREA)
  • Amplifiers (AREA)
  • Apparatuses For Generation Of Mechanical Vibrations (AREA)

Abstract

Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01 % wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.
CA002125027A 1992-11-02 1993-10-21 Stable microbubble suspensions as enhancement agents for ultrasound echography Expired - Lifetime CA2125027C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92810837 1992-11-02
EP92810837.2 1992-11-02

Publications (2)

Publication Number Publication Date
CA2125027A1 true CA2125027A1 (en) 1994-05-11
CA2125027C CA2125027C (en) 1998-12-01

Family

ID=8212014

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002125027A Expired - Lifetime CA2125027C (en) 1992-11-02 1993-10-21 Stable microbubble suspensions as enhancement agents for ultrasound echography

Country Status (22)

Country Link
US (7) US5445813A (en)
EP (1) EP0619743B1 (en)
JP (1) JP3135919B2 (en)
KR (1) KR100216138B1 (en)
CN (1) CN1069838C (en)
AT (1) ATE146972T1 (en)
AU (3) AU666238B2 (en)
CA (1) CA2125027C (en)
DE (2) DE69307124T2 (en)
DK (1) DK0619743T3 (en)
ES (1) ES2097548T3 (en)
FI (1) FI115953B (en)
GR (1) GR3022826T3 (en)
HU (1) HU227043B1 (en)
IL (1) IL107453A (en)
IS (1) IS1625B (en)
LU (1) LU90837I2 (en)
NL (1) NL300061I2 (en)
NO (1) NO308830B1 (en)
NZ (2) NZ280615A (en)
WO (1) WO1994009829A1 (en)
ZA (1) ZA938117B (en)

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