CA2122592A1 - System for Delivering an Active Substance for Sustained Release - Google Patents

System for Delivering an Active Substance for Sustained Release

Info

Publication number
CA2122592A1
CA2122592A1 CA 2122592 CA2122592A CA2122592A1 CA 2122592 A1 CA2122592 A1 CA 2122592A1 CA 2122592 CA2122592 CA 2122592 CA 2122592 A CA2122592 A CA 2122592A CA 2122592 A1 CA2122592 A1 CA 2122592A1
Authority
CA
Canada
Prior art keywords
active substance
delivering
sustained release
coating
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2122592
Other languages
French (fr)
Other versions
CA2122592C (en
Inventor
Terrence Bruce Mazer
Glenn Alan Meyer
Shie-Ming Hwang
Edrick Leonard Candler Jr.
Lonnie Richard Drayer
Andre Daab-Krzykowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Terrence Bruce Mazer
Glenn Alan Meyer
Shie-Ming Hwang
Edrick Leonard Candler Jr.
Lonnie Richard Drayer
Andre Daab-Krzykowski
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terrence Bruce Mazer, Glenn Alan Meyer, Shie-Ming Hwang, Edrick Leonard Candler Jr., Lonnie Richard Drayer, Andre Daab-Krzykowski, Abbott Laboratories filed Critical Terrence Bruce Mazer
Publication of CA2122592A1 publication Critical patent/CA2122592A1/en
Application granted granted Critical
Publication of CA2122592C publication Critical patent/CA2122592C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin

Abstract

A system for delivering an active substance has sustained release of the active substance in the intestinal tract. This delivery system is especially useful for an active substance such as a .beta.-lactam antibiotic which preferably has minimal exposure to the ac-idic environment of the stomach. Particles comprise an active ingredient disposed in a core which has at least one coating of a prolamine and one coating of an enteric compound thereon. The particles may be very small and suspended in a liquid medium.
CA002122592A 1991-12-31 1992-12-21 System for delivering an active substance for sustained release Expired - Fee Related CA2122592C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/816,412 US5160742A (en) 1991-12-31 1991-12-31 System for delivering an active substance for sustained release
US816,412 1991-12-31
PCT/US1992/011160 WO1993012772A1 (en) 1991-12-31 1992-12-21 System for delivering an active substance for sustained release

Publications (2)

Publication Number Publication Date
CA2122592A1 true CA2122592A1 (en) 1993-07-08
CA2122592C CA2122592C (en) 1997-08-05

Family

ID=25220519

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002122592A Expired - Fee Related CA2122592C (en) 1991-12-31 1992-12-21 System for delivering an active substance for sustained release

Country Status (7)

Country Link
US (1) US5160742A (en)
EP (1) EP0619733B1 (en)
AU (1) AU3418993A (en)
CA (1) CA2122592C (en)
DE (1) DE69232007T2 (en)
MX (1) MX9207263A (en)
WO (1) WO1993012772A1 (en)

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Also Published As

Publication number Publication date
MX9207263A (en) 1993-06-01
DE69232007D1 (en) 2001-09-20
EP0619733A4 (en) 1995-06-07
DE69232007T2 (en) 2002-04-18
US5160742A (en) 1992-11-03
AU3418993A (en) 1993-07-28
WO1993012772A1 (en) 1993-07-08
EP0619733A1 (en) 1994-10-19
CA2122592C (en) 1997-08-05
EP0619733B1 (en) 2001-08-16

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