CA2119154A1 - Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous Solubility and the Use Thereof - Google Patents

Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous Solubility and the Use Thereof

Info

Publication number
CA2119154A1
CA2119154A1 CA 2119154 CA2119154A CA2119154A1 CA 2119154 A1 CA2119154 A1 CA 2119154A1 CA 2119154 CA2119154 CA 2119154 CA 2119154 A CA2119154 A CA 2119154A CA 2119154 A1 CA2119154 A1 CA 2119154A1
Authority
CA
Canada
Prior art keywords
derivatives
cyclodextrins
aqueous solubility
exhibiting enhanced
enhanced aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2119154
Other languages
French (fr)
Other versions
CA2119154C (en
Inventor
Valentino J. Stella
Roger Rajewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kansas
Original Assignee
Valentino J. Stella
Roger Rajewski
The University Of Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25440795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2119154(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Valentino J. Stella, Roger Rajewski, The University Of Kansas filed Critical Valentino J. Stella
Publication of CA2119154A1 publication Critical patent/CA2119154A1/en
Application granted granted Critical
Publication of CA2119154C publication Critical patent/CA2119154C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Abstract

Sulfoalkyl ether cyclodextrin derivatives and their use as solubilizing agents for water insoluble drugs for oral, intranasal, or parenteral administration are disclosed.
CA002119154A 1992-07-27 1993-07-26 Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof Expired - Lifetime CA2119154C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/918,702 1992-07-27
US07/918,702 US5376645A (en) 1990-01-23 1992-07-27 Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof

Publications (2)

Publication Number Publication Date
CA2119154A1 true CA2119154A1 (en) 1994-02-03
CA2119154C CA2119154C (en) 1998-06-16

Family

ID=25440795

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002119154A Expired - Lifetime CA2119154C (en) 1992-07-27 1993-07-26 Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof

Country Status (16)

Country Link
US (1) US5376645A (en)
EP (1) EP0620828B2 (en)
JP (1) JP3393253B2 (en)
KR (1) KR100279111B1 (en)
AT (1) ATE217325T1 (en)
AU (1) AU672814B2 (en)
CA (1) CA2119154C (en)
DE (1) DE69331900T3 (en)
DK (1) DK0620828T4 (en)
ES (1) ES2176206T5 (en)
GE (1) GEP19991649B (en)
MD (1) MD1813C2 (en)
PT (1) PT620828E (en)
RU (1) RU2113442C1 (en)
TJ (1) TJ275B (en)
WO (1) WO1994002518A1 (en)

Families Citing this family (570)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0709099A3 (en) * 1994-09-28 1996-07-24 Senju Pharma Co An aqueous nasal suspension comprising cyclodextrin
ZA959469B (en) * 1994-11-15 1996-05-15 South African Druggists Ltd Pharmaceutical composition
US5468502A (en) * 1994-12-20 1995-11-21 American Home Products Corporation Ibuprofen enhancing solvent system
AU5774796A (en) * 1995-06-13 1997-01-09 Dyer, Alison Margaret Pharmaceutical compositions containing lornoxicam and cyclod extrin
JP2000509374A (en) 1996-04-19 2000-07-25 アルファ セラピュティック コーポレイション Method for virus inactivation of lyophilized blood proteins
UA57734C2 (en) 1996-05-07 2003-07-15 Пфайзер Інк. Arylheterocyclic inclusion complexes
US5906981A (en) * 1996-06-04 1999-05-25 Troy Corporation Halopropargyl inclusion complexes
DK0877600T3 (en) * 1996-08-09 2004-02-02 Alcon Mfg Ltd Preservation system for pharmaceutical preparations containing cyclodextrin
DE19716120A1 (en) * 1997-04-17 1998-10-22 Europ Lab Molekularbiolog Use of cholesterol-lowering agents
US6046177A (en) * 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
ATE253941T1 (en) * 1997-06-13 2003-11-15 Cydex Inc COMPOSITION WITH INCREASED STORAGE STABILITY CONTAINING CYCLODEXTRIN AND ACTIVE INGREDIENTS OR ACTIVE INGREDIENTS WHICH ARE DECOMPOSED INTO WATER-INSOLUBLE COMPONENTS
GB9713149D0 (en) * 1997-06-21 1997-08-27 Pfizer Ltd Pharmaceutical formulations
DE69834154T2 (en) * 1997-07-01 2007-01-25 Pfizer Products Inc., Groton Process for the preparation of a cyclodextrin
EP1029872A4 (en) * 1997-11-07 2001-05-02 Daiichi Seiyaku Co Piperazine-cyclodextrin complexes
WO1999042111A1 (en) * 1998-02-23 1999-08-26 Cyclops, Ehf. High-energy cyclodextrin complexes
US6699849B1 (en) 1998-02-23 2004-03-02 Cyclops, Ehf. Cyclodextrin complexes of benzodiazepines
WO2000012137A1 (en) * 1998-09-02 2000-03-09 Allergan Sales, Inc. Preserved cyclodextrin-containing compositions
FR2784584B1 (en) * 1998-10-14 2002-09-20 Adir PROCESS FOR THE PREPARATION OF A NASAL SPRAY SOLUTION CONTAINING ONE OR MORE SEXUAL HORMONES AND A CYCLODEXTRIN
JP2002531530A (en) * 1998-12-04 2002-09-24 カリフォルニア インスティテュート オブ テクノロジー Supramolecular complexes containing therapeutic agents
US7375096B1 (en) 1998-12-04 2008-05-20 California Institute Of Technology Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
CA2359646C (en) 1999-01-21 2008-12-02 Bristol-Myers Squibb Company Complex of ras-farnesyltransferase inhibitor and sulfobutylether-7-.beta.-cyclodextrin or 2-hydroxypropyl-.beta.-cyclodextrin and method
GB9913932D0 (en) 1999-06-15 1999-08-18 Pfizer Ltd Purine derivatives
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
CA2315614C (en) 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
GB9924363D0 (en) 1999-10-14 1999-12-15 Pfizer Central Res Purine derivatives
GB9924361D0 (en) 1999-10-14 1999-12-15 Pfizer Ltd Purine derivatives
WO2001030391A2 (en) * 1999-10-27 2001-05-03 Farmarc Nederland Bv Pharmaceutical composition containing midazolam
WO2001072338A1 (en) * 2000-03-28 2001-10-04 Farmarc Nederland Bv Alprazolam inclusion complexes and pharmaceutical compositions thereof
ATE416791T1 (en) 2000-05-02 2008-12-15 Theravance Inc COMPOSITION CONTAINING A CYCLODEXTRIN AND A GLYCOPEPTIDE ANTIBIOTIC
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
AU5248201A (en) 2000-05-26 2001-12-03 Manoussos Perros Tropane derivatives useful in therapy
US6753322B2 (en) 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
US6921753B2 (en) 2000-06-27 2005-07-26 Pfizer Inc Purine derivatives
US6468989B1 (en) 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
US6420557B1 (en) 2000-07-28 2002-07-16 Pfizer Inc. Crystalline therapeutic agent
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
KR100856523B1 (en) * 2000-08-03 2008-09-04 안타레스 파르마 아이피엘 에이쥐 Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
PE20020300A1 (en) * 2000-08-22 2002-05-10 Pharmacia Corp COMPOSITION OF SOLUTION OF AN ANTIBIOTIC DRUG BASED ON OXAZOLIDINONE WITH IMPROVEMENT OF DRUG LOAD
GB0022695D0 (en) 2000-09-15 2000-11-01 Pfizer Ltd Purine Derivatives
PE20020578A1 (en) 2000-10-10 2002-08-14 Upjohn Co A TOPICAL ANTIBIOTIC COMPOSITION FOR THE TREATMENT OF EYE INFECTIONS
US6548508B2 (en) 2000-10-20 2003-04-15 Pfizer, Inc. Use of PDE V inhibitors for improved fecundity in mammals
US6566556B2 (en) * 2000-12-19 2003-05-20 Nippon Shokubai Co., Ltd. Method for production of alkanolamine and apparatus therefor
JP2005503446A (en) 2001-01-11 2005-02-03 イーストマン ケミカル カンパニー Cyclodextrin sulfonate, guest inclusion complex, production method thereof and related substances
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
IL141647A0 (en) * 2001-02-26 2002-03-10 Yeda Res & Dev Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus
US6579898B2 (en) 2001-03-01 2003-06-17 Pfizer Inc. Compositions having improved bioavailability
US7034013B2 (en) * 2001-03-20 2006-04-25 Cydex, Inc. Formulations containing propofol and a sulfoalkyl ether cyclodextrin
PT1377556E (en) 2001-04-10 2007-06-06 Pfizer Ltd Pyrazole derivatives for treating hiv
WO2002087546A2 (en) * 2001-05-01 2002-11-07 Pfizer Products Inc. Method for manufacturing a low dose pharmaceutical composition
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
US7008934B2 (en) * 2001-06-28 2006-03-07 Baxter International Inc. Composition and method for reducing adverse interactions between phenothiazine derivatives and plasma using cyclodextrins
MXPA03011793A (en) * 2001-06-29 2004-04-02 Maxygen Holdings Ltd Interferon formulations.
GB0116453D0 (en) 2001-07-05 2001-08-29 Imp College Innovations Ltd Method
EP1411915A2 (en) * 2001-07-20 2004-04-28 Dynamit Nobel GmbH Nitrate ester-cyclodextrin complexes for treating diseases, particularly coronary diseases
US6653339B2 (en) 2001-08-15 2003-11-25 Pfizer Inc. Method of treating irritable bowel syndrome
US7141540B2 (en) * 2001-11-30 2006-11-28 Genta Salus Llc Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
GB0129273D0 (en) 2001-12-06 2002-01-23 Pfizer Ltd Crystalline drug form
US6881726B2 (en) 2001-12-24 2005-04-19 Dow Pharmaceutical Sciences Aqueous compositions containing metronidazole
KR20040083493A (en) 2002-02-01 2004-10-02 화이자 프로덕츠 인크. Controlled release pharmaceutical dosage forms of a cholesteryl ester transfer protein inhibitor
AU2003245711A1 (en) 2002-02-11 2003-09-04 Pfizer Inc. Nicotinamide derivatives useful as pde4 inhibitors
US6756392B2 (en) 2002-02-11 2004-06-29 Pfizer Inc Nicotinamide derivatives useful as PDE4 inhibitors
TW200400055A (en) * 2002-02-22 2004-01-01 Pharmacia Corp Ophthalmic formulation with novel gum composition
BR0307898A (en) * 2002-02-22 2004-12-07 Pharmacia Corp Ophthalmic antibiotic drug formulations containing a cyclodextrin compound and cetyl pyridinium chloride
GB0207104D0 (en) 2002-03-26 2002-05-08 Pfizer Ltd Stable hydrate of a muscarinic receptor antagonist
US6855724B2 (en) 2002-04-08 2005-02-15 Agouron Pharmaceuticals, Inc. Tropane derivatives useful in therapy
GB0209022D0 (en) 2002-04-19 2002-05-29 Imp College Innovations Ltd Compounds
US6869939B2 (en) * 2002-05-04 2005-03-22 Cydex, Inc. Formulations containing amiodarone and sulfoalkyl ether cyclodextrin
US6818662B2 (en) * 2002-05-28 2004-11-16 Taisho Pharmaceutical Co., Ltd. Pharmaceutical composition
GB0212749D0 (en) * 2002-06-01 2002-07-10 Boots Co Plc Personal care compositions
EP1542668B1 (en) * 2002-08-20 2009-04-15 Bristol-Myers Squibb Company Aripiprazole complex formulation and method
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
PT2277551E (en) 2002-09-06 2013-08-22 Cerulean Pharma Inc Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
GB0221169D0 (en) 2002-09-12 2002-10-23 Univ Bath Crystal
CA2498410A1 (en) * 2002-09-13 2004-03-25 Cydex, Inc. Capsules containing aqueous fill compositions stabilized with derivatized cyclodextrin
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US7230025B2 (en) 2002-09-26 2007-06-12 Pfizer, Inc. Pyrazole derivatives
US6933312B2 (en) 2002-10-07 2005-08-23 Agouron Pharmaceuticals, Inc. Pyrazole derivatives
IL152575A (en) * 2002-10-31 2008-12-29 Transpharma Medical Ltd Transdermal delivery system for water insoluble drugs
IL152573A (en) * 2002-10-31 2009-11-18 Transpharma Medical Ltd Transdermal delivery system for anti-emetic medication
US7323462B2 (en) 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
KR20070091049A (en) 2002-12-13 2007-09-06 워너-램버트 캄파니 엘엘씨 Alpha-2-delta ligand to treat lower urinary tract symptoms
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
NZ541658A (en) * 2003-01-14 2008-04-30 Teva Pharma Parenteral formulations of peptides for the treatment of systemic lupus erythematosus
UA83816C2 (en) * 2003-01-14 2008-08-26 Тева Фармасьютикал Индастриз, Лтд Pharmaceutical composition comprising a peptide and substituted -cyclodextrin for the treatment of systemic lupus erythematosus
EP1460064A1 (en) 2003-03-14 2004-09-22 Pfizer Limited Indole-2-carboxamide derivatives useful as beta-2 agonists
EP2301549A1 (en) * 2003-04-18 2011-03-30 Advanced Medicine Research Institute Remedies for diseases to be applied to eye
CL2004000826A1 (en) 2003-04-25 2005-03-04 Pfizer USE OF AN AGONIST FOR THE 5-HT2C RECEPTOR TO PREPARE A USEFUL MEDICINAL PRODUCT IN THE TREATMENT OF URINARY INCONTINENCE CAUSED BY STRESS, WITH THE CONDITION THAT THE AGONIST IS NOT 1- [6-CHLORINE-5- (TRIFLUOROMETIL) -2- PIRIDINIL] PIPERAZINA (ORG-129
US7157446B2 (en) * 2003-05-02 2007-01-02 Bristol Myers Squibb Company Complex of ras-farnesyltransferase inhibitor, a cyclodextrin, and ethanol
US7268147B2 (en) 2003-05-15 2007-09-11 Pfizer Inc Compounds useful for the treatment of diseases
DE602004024417D1 (en) 2003-09-03 2010-01-14 Glaxo Group Ltd NEW METHOD FOR THE PRODUCTION OF PLEUROMUTILINE DERIVATIVES
AU2004268840B9 (en) 2003-09-03 2011-02-03 Pfizer Inc. Benzimidazolone compounds having 5-HT4 receptor agonistic activity
US7220772B2 (en) 2003-09-05 2007-05-22 Pfizer, Inc. Pyrazole derivatives
US6960300B2 (en) * 2003-09-08 2005-11-01 Sami Labs Limited Process for preparing water soluble diterpenes and their applications
CA2537402C (en) 2003-09-12 2009-05-05 Pfizer Inc. Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
MXPA06003749A (en) 2003-10-03 2006-06-14 Pfizer Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation.
NZ546106A (en) 2003-10-10 2008-10-31 Antares Pharma Ipl Ag Transdermal pharmaceutical formulation for minimizing skin residues
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
US7129042B2 (en) * 2003-11-03 2006-10-31 Diagnostic Hybrids, Inc. Compositions and methods for detecting severe acute respiratory syndrome coronavirus
ATE497763T1 (en) 2003-11-21 2011-02-15 Zalicus Inc METHODS AND REAGENTS FOR TREATING INFLAMMATORY DISEASES
AU2004312095A1 (en) * 2003-12-31 2005-07-21 Cydex Pharmaceuticals, Inc. Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid prepared from a unit dose suspension
US20070020196A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid prepared from a unit dose suspension
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
PT1708991E (en) 2004-01-22 2007-12-14 Pfizer Sulfonamide derivatives for the treatment of diseases
AU2005214154B2 (en) 2004-01-22 2008-01-24 Pfizer Inc. Sulfonamide derivatives for the treatment of diseases
US7629358B2 (en) 2004-03-17 2009-12-08 Pfizer Inc Compounds useful for the treatment of diseases
AU2005223483B2 (en) 2004-03-18 2009-04-23 Zoetis Llc N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides
US7538141B2 (en) 2004-03-23 2009-05-26 Alan Daniel Brown Compounds for the treatment of diseases
EP1730103B1 (en) 2004-03-23 2010-05-26 Pfizer Limited Formamide derivatives useful as adrenoceptor
CN103554222A (en) * 2004-04-15 2014-02-05 欧尼斯治疗公司 Compounds for enzyme inhibition
US8198270B2 (en) * 2004-04-15 2012-06-12 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
US20050234018A1 (en) * 2004-04-15 2005-10-20 Allergan, Inc. Drug delivery to the back of the eye
SI2708225T1 (en) * 2004-04-23 2019-05-31 Cydex Pharmaceuticals, Inc. DPI Formulation Containing Sulfoalkyl Ether Cyclodextrin
CA2564994A1 (en) 2004-04-30 2005-11-10 Warner-Lambert Company Llc Substituted morpholine compounds for the treatment of central nervous system disorders
US20050250738A1 (en) * 2004-05-06 2005-11-10 Mosher Gerold L Taste-masked formulations containing sertraline and sulfoalkyl ether cyclodextrin
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
SI2030981T1 (en) * 2004-05-10 2014-11-28 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
EP1595881A1 (en) 2004-05-12 2005-11-16 Pfizer Limited Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
AU2005254800B2 (en) 2004-06-15 2010-12-09 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
SI1778686T1 (en) 2004-08-12 2009-02-28 Pfizer Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors
PT1786785E (en) 2004-08-26 2010-05-21 Pfizer Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
ITMI20041763A1 (en) * 2004-09-16 2004-12-16 Altergon Sa NEW INJECTABLE FORMULATIONS CONTAINING PROGESTERONE
MX2007005290A (en) 2004-11-02 2007-07-09 Pfizer Sulfonyl benzimidazole derivatives.
US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
GT200500317A (en) * 2004-11-05 2006-10-27 PROCESS TO PREPARE QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED FROM THEM
US20060105045A1 (en) * 2004-11-08 2006-05-18 Buchanan Charles M Cyclodextrin solubilizers for liquid and semi-solid formulations
US20060105992A1 (en) * 2004-11-08 2006-05-18 Buchanan Charles M Pharmaceutical formulations of cyclodextrins and selective estrogen receptor modulator compounds
EP1819353B1 (en) * 2004-12-07 2011-02-23 Proteolix, Inc. Composition for proteasome inhibition
EP1674098A1 (en) 2004-12-23 2006-06-28 Schering Aktiengesellschaft Stable and tolerable parental formulations of highly reactive organic drug substances with low or no solubility in water
WO2006091885A2 (en) 2005-02-24 2006-08-31 Dr Pharma Nova, Llc A registry method and control system for dea schedule ii-v medicines
CA2601508C (en) 2005-03-17 2012-01-03 Pfizer, Inc. Cyclopropanecarboxamide derivatives
ES2313626T3 (en) 2005-03-21 2009-03-01 Pfizer Limited TRIAZOL DERIVATIVES SUBSTITUTED AS AN OXITOCINE ANTAGONISTS.
US7745494B2 (en) * 2005-04-15 2010-06-29 Albert Einstein College Of Medicine Of Yeshiva University Vitamin K for prevention and treatment of skin rash secondary to anti-EGFR therapy
DK1874331T3 (en) 2005-04-19 2014-12-01 King S College London APPLICATION OF BIP against bone loss and osteoporosis
GT200600162A (en) * 2005-04-24 2007-03-14 METHODS TO MODULATE THE FUNCTION OF THE BLADDER
CA2607780A1 (en) 2005-05-04 2006-11-09 Pfizer Limited Purine derivatives
ES2393768T3 (en) 2005-05-26 2012-12-27 Neuron Systems, Inc Quinoline derivative for the treatment of retinal diseases
US8067399B2 (en) 2005-05-27 2011-11-29 Antares Pharma Ipl Ag Method and apparatus for transdermal or transmucosal application of testosterone
JPWO2006134877A1 (en) * 2005-06-13 2009-01-08 武田薬品工業株式会社 Injection
WO2006134468A1 (en) 2005-06-15 2006-12-21 Pfizer Limited Substituted arylpyrazoles for use against parasitites
US20080146643A1 (en) * 2005-06-15 2008-06-19 Pfizer Limited Combination
US7645786B2 (en) 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
US20080176865A1 (en) * 2005-06-15 2008-07-24 Pfizer Limited Substituted arylpyrazoles
AR054849A1 (en) * 2005-07-26 2007-07-18 Wyeth Corp DIAZEPINOQUINOLINAS, SYNTHESIS OF THE SAME, AND INTERMEDIARIES TO OBTAIN THEM
US20070191306A1 (en) * 2005-08-17 2007-08-16 Bristol-Myers Squibb Company FACTOR Xa INHIBITOR FORMULATION AND METHOD
DE102005041860A1 (en) * 2005-09-02 2007-03-08 Schering Ag Nano-particle embedded- and charged-complex, useful for the production of a pharmaceutical composition, comprises two complex partners, where the complex partner is an embedded anionic and a cationic active substance
MX2008004287A (en) 2005-09-30 2008-10-23 Ovation Pharmaceuticals Inc Novel parenteral carbamazepine formulation.
US20100204178A1 (en) * 2006-10-02 2010-08-12 James Cloyd Novel parenteral carbamazepine formulation
PL2335707T3 (en) * 2005-10-26 2015-10-30 Cydex Pharmaceuticals Inc Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US8716322B2 (en) 2005-11-09 2014-05-06 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
ES2812250T3 (en) 2005-11-28 2021-03-16 Marinus Pharmaceuticals Inc Ganaxolone formulations and procedures for their preparation and use
US20070135586A1 (en) * 2005-12-09 2007-06-14 Shreyas Chakravarti Polyamide blend compositions formed article and process thereof
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
JP2009520823A (en) * 2005-12-20 2009-05-28 ティカ レーケメデル アーベー Methods and systems for delivering corticosteroids with improved pharmacokinetic profiles
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
NL2000323C2 (en) 2005-12-20 2007-11-20 Pfizer Ltd Pyrimidine derivatives.
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070178049A1 (en) * 2005-12-20 2007-08-02 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070141684A1 (en) 2005-12-21 2007-06-21 Pfizer Inc Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
GB0600406D0 (en) 2006-01-10 2006-02-15 Univ Bath Crystal
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
WO2007095341A2 (en) * 2006-02-15 2007-08-23 Tika Läkemedel Ab Sterilization of corticosteroids with reduced mass loss
US20070225274A1 (en) * 2006-03-24 2007-09-27 Wyeth Methods for modulating bladder function
CL2007000773A1 (en) * 2006-03-24 2008-01-25 Wyeth Corp Use of compounds derived from condensed diazepine for the treatment of a cognitive disorder such as add or adhd; or its use to treat spm or pmdd.
AU2007231011A1 (en) * 2006-03-24 2007-10-04 Wyeth New therapeutic combinations for the treatment of depression
PE20081192A1 (en) * 2006-03-24 2008-10-07 Wyeth Corp PAIN TREATMENT
CL2007000775A1 (en) * 2006-03-24 2008-01-25 Wyeth Corp Use of benzofuran-derived compounds for the treatment of a cognitive disorder.
US20070238789A1 (en) * 2006-03-31 2007-10-11 Chin-Ming Chang Prednisolone acetate compositions
BRPI0710287A2 (en) * 2006-04-18 2012-05-29 Ekr Therapeutics Inc pharmaceutical composition, method for treating an individual for high blood pressure, inclusion complex, and methods for treating and preventing acute elevations of blood pressure in a human individual and for inducing hypotension in a human individual.
CA2646667C (en) 2006-04-21 2014-03-11 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
CN100374468C (en) * 2006-05-25 2008-03-12 重庆通量精细化工有限公司 Synthetic process for water soluble sulfoalkyl ether-beta-cyclic dextrine
AU2007261345B2 (en) 2006-06-19 2012-02-23 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
WO2008003317A1 (en) * 2006-07-03 2008-01-10 Genmab A/S Prevention of rash in patients undergoing anti-egfr therapy
AR061889A1 (en) 2006-07-13 2008-10-01 Medichem Sa IMPROVED PROCESS FOR THE PREPARATION OF VORICONAZOL
WO2008012538A2 (en) 2006-07-25 2008-01-31 The Secretary Of State For Defence Live vaccine strains of francisella
US20100022481A1 (en) * 2006-08-02 2010-01-28 Dong Wang Drug Carriers, Their Synthesis, and Methods of Use Thereof
US20080207731A1 (en) 2006-08-23 2008-08-28 Intellect Neurosciences, Inc. 3-(3-indolyl) propionic acid calcium salt and method of making 3-(3-indolyl) propionic acid free acid therefrom
US20100093861A1 (en) 2006-09-15 2010-04-15 Stevia Aps Treatment of insulin resistance or diseases associated with insulin resistance
US20090239942A1 (en) * 2006-09-15 2009-09-24 Cloyd James C Topiramate Compositions and Methods of Making and Using the Same
EP2061458B1 (en) * 2006-09-15 2014-12-10 Regents of the University of Minnesota Topiramate compositions and methods for their use
CA2657550C (en) 2006-09-21 2011-11-01 Raqualia Pharma Inc. Benzimidazole derivatives as selective acid pump inhibitors
JP2010506839A (en) 2006-10-12 2010-03-04 ワイス エルエルシー Methods and compositions with reduced opalescence
MX2009004233A (en) 2006-10-18 2009-08-12 Pfizer Prod Inc Biaryl ether urea compounds.
US8455471B2 (en) 2006-10-20 2013-06-04 Icos Corporation Compositions of CHK1 inhibitors and cyclodextrin
WO2008050199A2 (en) 2006-10-23 2008-05-02 Pfizer Japan Inc. Substituted phenylmethyl bicyclocarboxyamide compounds
US8158609B1 (en) * 2006-11-02 2012-04-17 Novartis Ag Use of cyclodextrins as an active ingredient for treating dry AMD and solubilizing drusen
JP5401319B2 (en) 2006-11-03 2014-01-29 ワイス・エルエルシー Glycolytic inhibitors in cell culture
KR100822133B1 (en) * 2006-11-06 2008-04-15 한미약품 주식회사 Complex formulation for preventing or treating osteoporosis which comprises solid dispersion of vitamin d or its derivative and bisphosphonate
US20100056500A1 (en) * 2006-11-21 2010-03-04 Thitiwan Buranachokaisan Stable Parenteral Formulation
JP2010516625A (en) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド Polymer-drug conjugates with tether groups for controlled drug delivery
DK2115126T3 (en) 2007-03-02 2015-05-04 Wyeth Llc Use of copper and glutamate in cell culture for the preparation of polypeptides
CN101657203B (en) * 2007-03-02 2012-09-05 卧龙岗大学 Compositions and methods for delivery of anti-cancer agents
AU2015255164B2 (en) * 2007-04-27 2017-06-08 Cydex Pharmaceuticals, Inc. Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
WO2008134600A1 (en) * 2007-04-27 2008-11-06 Cydex Pharmaceuticals, Inc. Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
US7960353B2 (en) * 2007-05-10 2011-06-14 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
JP2010527986A (en) * 2007-05-24 2010-08-19 ファイザー・リミテッド Spirocyclic quinazoline derivatives and their use as PDE7 inhibitors
WO2008147556A2 (en) 2007-05-25 2008-12-04 Ipsen Pharma S.A.S. Melanocortin receptor ligands modified with hydantoin
ES2493641T3 (en) * 2007-06-28 2014-09-12 Cydex Pharmaceuticals, Inc. Nasal administration of aqueous corticosteroid solutions
TWI428132B (en) 2007-07-02 2014-03-01 Lilly Co Eli Potentiation of cancer chemotherapy
GB0714030D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
GB0714029D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
KR100929920B1 (en) 2007-09-05 2009-12-04 주식회사 마크로케어 Method for preparing clathrate containing hydrophobic physiologically active ingredient in cyclodextrin and derivatives thereof and use of clathrate prepared thereby
EP2215087B1 (en) 2007-09-05 2013-12-18 Rigel Pharmaceuticals, Inc. Xinafoate salt of n4- (2,2-difluoro-4h-benzo [1,4] oxazin-3-one) - 6-yl] - 5-fluoro-n2 - [3-(methylaminocarbonylmethyleneoxy) phenyl] 2,4-pyrimidinediamine
CL2008002777A1 (en) * 2007-09-21 2010-01-22 Wyeth Corp Method of preparing chiral diazepinoquinoline compounds by recrystallization in a ternary solvent system.
ME02462B (en) * 2007-10-04 2017-02-20 Onyx Therapeutics Inc Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
EP2057982A1 (en) * 2007-11-09 2009-05-13 Archimedes Development Limited Intranasal compositions
US7999741B2 (en) * 2007-12-04 2011-08-16 Avaya Inc. Systems and methods for facilitating a first response mission at an incident scene using precision location
US8192721B2 (en) * 2007-12-13 2012-06-05 Verrow Pharmaceuticals, Inc. Compositions useful for reducing toxicity associated with gadolinium-based contrast agents
US8815953B2 (en) * 2008-03-13 2014-08-26 Spectrum Pharmaceuticals, Inc. Formulations of vitamin K analogs for topical use
GB2458473A (en) 2008-03-17 2009-09-23 Imuthes Ltd 3'-O-allyl- and 3'-O-carboxymethyl- 2'-aminosaccharide derivatives, & amides thereof with peptides, as adjuvants
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
US20110224232A1 (en) * 2008-05-06 2011-09-15 Board Of Regents, The University Of Texas System Treatment of Pulmonary Fungal Infection With Voriconazole via Inhalation
EP2303229A1 (en) * 2008-06-16 2011-04-06 Debiopharm S.A. Concentrated oxaliplatin solution and its method of preparation
US20100022635A1 (en) * 2008-07-28 2010-01-28 University Of Kansas Heat shock protein 90 inhibitor dosing methods
EP2328890B1 (en) 2008-08-06 2012-01-25 Pfizer Inc. 6 substituted 2-heterocyclylamino pyrazine compounds as chk-1 inhibitors
EP2163253B1 (en) 2008-09-15 2013-07-17 ULLRICH, Oliver Extracts from the plant Hornstedtia scyphifera and immunosuppressive effects thereof
US20100093872A1 (en) * 2008-10-15 2010-04-15 Erimos Pharmaceuticals Llc Stable aqueous formulations of water insoluble or poorly soluble drugs
JP5675629B2 (en) 2008-10-21 2015-02-25 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Combination therapy using peptide epoxyketone
WO2010053487A1 (en) 2008-11-07 2010-05-14 Cydex Pharmaceuticals, Inc. Composition containing sulfoalkyl ether cyclodextrin and latanoprost
PE20160116A1 (en) 2008-11-15 2016-03-09 Melinta Therapeutics Inc ANTIMICROBIAL COMPOSITIONS
MX2011005221A (en) 2008-11-21 2011-08-03 Raqualia Pharma Inc Novel pyrazole-3-carboxamide derivative having 5-ht2b receptor antagonist activity.
WO2010080528A1 (en) 2008-12-17 2010-07-15 Genentech, Inc. Hepatitis c virus combination therapy
WO2010079443A1 (en) 2009-01-12 2010-07-15 Pfizer Limited Sulfonamide derivatives
GB0900599D0 (en) 2009-01-14 2009-02-18 Novacta Biosystems Ltd Treatment
TWI453029B (en) 2009-01-14 2014-09-21 Novacta Biosystems Ltd Deoxyactagardine b, pharmaceutical composition comprising the same and method for preparing it
CN102388060B (en) 2009-02-04 2014-09-10 诺瓦克塔生物系统有限公司 Actagardine derivatives
WO2010103070A2 (en) 2009-03-12 2010-09-16 Charité - Universitätsmedizin Berlin Bone morphogenetic protein 2 (bmp2) variants with reduced bmp antagonist sensitivity
TWI504598B (en) 2009-03-20 2015-10-21 Onyx Therapeutics Inc Crystalline tripeptide epoxy ketone protease inhibitors
EP2233502A1 (en) 2009-03-27 2010-09-29 Deutsches Rheuma-Forschungszentrum Berlin Sialylated antigen-specific antibodies for treatment or prophylaxis of unwanted inflammatory immune reactions and methods of producing them
WO2010116270A1 (en) 2009-04-10 2010-10-14 Pfizer Inc. Ep2/4 agonists
GB0906234D0 (en) 2009-04-14 2009-05-20 Secr Defence Vaccine
KR20190071006A (en) 2009-05-13 2019-06-21 사이덱스 파마슈티칼스, 인크. Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
CA2763365C (en) 2009-05-29 2016-09-13 Cydex Pharmaceuticals, Inc. Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
CA2760284A1 (en) 2009-05-29 2010-12-02 Pfizer Limited Novel glucocorticoid receptor agonists
US8492538B1 (en) 2009-06-04 2013-07-23 Jose R. Matos Cyclodextrin derivative salts
EP2266563A1 (en) 2009-06-11 2010-12-29 Charité-Universitätsmedizin Berlin (Charité) Use of opioid receptor antagonists for acute treatment of paraphilic arousal states
EP2442791B1 (en) 2009-06-16 2019-11-27 Pfizer Inc. Dosage forms of apixaban
WO2011004276A1 (en) 2009-07-06 2011-01-13 Pfizer Limited Hepatitis c virus inhibitors
DE102009034368A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-acyloxyalkylenephenyl derivatives, process for their preparation and their use for the treatment of diseases
WO2011041593A1 (en) * 2009-09-30 2011-04-07 University Of Kansas Novobiocin analogues and treatment of polycystic kidney disease
WO2011060179A1 (en) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Use of peptide epoxyketones for metastasis suppression
WO2011077313A1 (en) 2009-12-22 2011-06-30 Pfizer Inc. Piperidinecarboxamides as mpges - 1 inhibitors
NZ601267A (en) 2009-12-23 2014-03-28 Takeda Pharmaceutical Fused heteroaromatic pyrrolidinones as syk inhibitors
WO2011083387A1 (en) 2010-01-07 2011-07-14 Pfizer Limited Hydrochloride salt of biphenyl-2-yl-carbamic acid 1-{9-[(3-fluoro-4-hydroxy-benzoyl)-methyl-amino]-nonyl}-piperidin-4-yl ester
SI2525798T1 (en) 2010-01-21 2018-01-31 Drawbridge Pharmaceuticals Pty Ltd. Anaesthetic formulation
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
US20120309676A1 (en) 2010-02-02 2012-12-06 Sjoerd Nicolaas Wadman Lantibiotic Salts
EP2539358A1 (en) 2010-02-25 2013-01-02 Pfizer Limited Peptide analogues
KR20130075723A (en) 2010-03-01 2013-07-05 오닉스 세라퓨틱스, 인크. Compounds for immunoproteasome inhibition
AU2011228758A1 (en) * 2010-03-13 2012-11-08 Eastpond Laboratories Limited Fat-binding compositions
KR20130094185A (en) 2010-04-07 2013-08-23 오닉스 세라퓨틱스, 인크. Crystalline peptide epoxyketone immunoproteasome inhibitor
US8916593B2 (en) 2010-05-04 2014-12-23 Pfizer Inc. Alkoxy-substituted 2-aminopyridines as ALK inhibitors
WO2011149349A1 (en) 2010-05-26 2011-12-01 Neurophyxia B.V. 2-iminobiotin formulations and uses thereof
WO2011154871A1 (en) 2010-06-10 2011-12-15 Pfizer Limited Hepatitis c virus inhibitors
EP2579869A2 (en) * 2010-06-11 2013-04-17 Baxter International Inc Formulations including amiodarone and salts thereof and methods of their manufacture and use
CA2804593C (en) 2010-07-09 2015-11-24 Pfizer Limited Biphenyloxybenzensulphonamide derivatives useful as sodium channel inhibitors
US9145407B2 (en) 2010-07-09 2015-09-29 Pfizer Limited Sulfonamide compounds
US9096558B2 (en) 2010-07-09 2015-08-04 Pfizer Limited N-sulfonylbenzamide compounds
US9096500B2 (en) 2010-07-12 2015-08-04 Pfizer Limited Acyl sulfonamide compounds
EP2593427B1 (en) 2010-07-12 2014-12-24 Pfizer Limited Sulfonamide derivatives as nav1.7 inhibitors for the treatment of pain
US8772343B2 (en) 2010-07-12 2014-07-08 Pfizer Limited Chemical compounds
CA2801032A1 (en) 2010-07-12 2012-01-19 Pfizer Limited N-sulfonylbenzamide derivatives useful as voltage gated sodium channel inhibitors
US9102621B2 (en) 2010-07-12 2015-08-11 Pfizer Limited Acyl sulfonamide compounds
GB201013507D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
GB201013509D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013508D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
CN103154012B (en) 2010-08-24 2015-11-25 英皇创新有限公司 The sugared dendrimer of poly-propyl ether imines
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
WO2012061413A2 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compositions and methods for the treatment of cancer
EP2640729B1 (en) 2010-11-15 2016-12-21 VIIV Healthcare UK Limited Inhibitors of hiv replication
WO2012095781A1 (en) 2011-01-13 2012-07-19 Pfizer Limited Indazole derivatives as sodium channel inhibitors
KR101914940B1 (en) 2011-01-26 2018-11-06 알러간, 인코포레이티드 Androgen composition for treating an opthalmic condition
US8791107B2 (en) 2011-02-25 2014-07-29 Takeda Pharmaceutical Company Limited N-substituted oxazinopteridines and oxazinopteridinones
WO2012120398A1 (en) 2011-03-04 2012-09-13 Pfizer Limited Aryl substituted carboxamide derivatives as trpm8 modulators
MA35024B1 (en) 2011-04-05 2014-04-03 Pfizer Ltd PYRROLO- [2,3-D] PYRIMIDINE DERIVATIVES AS INHIBITORS OF TROPOMYOSIN-RELATED KINASES
WO2012157288A1 (en) 2011-05-18 2012-11-22 Raqualia Pharma Inc. Polymorph form of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2h-pyran-4-carboxylic acid
TWI544922B (en) 2011-05-19 2016-08-11 愛爾康研究有限公司 High concentration olopatadine ophthalmic composition
KR101731155B1 (en) 2011-06-15 2017-04-27 신톤 비.브이. Stabilized voriconazole composition
WO2012177714A1 (en) 2011-06-22 2012-12-27 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
EP2731959B1 (en) 2011-07-13 2016-02-03 Pfizer Limited Enkephalin analogues
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
WO2013017136A1 (en) 2011-08-02 2013-02-07 Pensieve Biosciences Cyprus Limited Treatment of cognitive impairment
US20160206608A1 (en) 2011-08-02 2016-07-21 Pfizer Inc. Crizotinib for use in the treatment of cancer
DK2753632T3 (en) 2011-09-08 2023-07-10 Sage Therapeutics Inc NEUROACTIVE STEROIDS, COMPOSITIONS AND USE THEREOF
EP3318284B1 (en) 2011-09-18 2022-01-26 Euro-Celtique S.A. Pharmaceutical composition comprising an hdac inhibitor and a cyclopolysaccharide
WO2013054185A1 (en) 2011-10-13 2013-04-18 Pfizer, Inc. Pyrimidine and pyridine derivatives useful in therapy
EP3572417A3 (en) 2011-10-14 2020-03-25 Sage Therapeutics, Inc. 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
JP5363636B2 (en) 2011-10-21 2013-12-11 ファイザー・リミテッド New salts and medical uses
WO2013061205A2 (en) 2011-10-26 2013-05-02 Pfizer Limited Chemical compounds
CN103958481B (en) 2011-10-28 2017-06-30 因西必泰克新有限公司 Can be used for the pyridyl derivatives treated
EP2791108B1 (en) 2011-12-15 2016-07-27 Pfizer Limited Sulfonamide derivatives
WO2013093688A1 (en) 2011-12-19 2013-06-27 Pfizer Limited Sulfonamide derivatives and use thereof as vgsc inhibitors
TW201332572A (en) 2011-12-28 2013-08-16 Otsuka Pharma Co Ltd Pharmaceutical preparation comprising substituted β -cyclodextrin
EP2800740A1 (en) 2012-01-04 2014-11-12 Pfizer Limited N-aminosulfonyl benzamides
GB201201332D0 (en) 2012-01-26 2012-03-14 Imp Innovations Ltd Method
TWI573792B (en) 2012-02-01 2017-03-11 歐陸斯迪公司 Novel therapeutic agents
ES2548228T3 (en) 2012-02-03 2015-10-15 Pfizer Inc Benzimidazole and imidazopyridine derivatives as sodium channel modulators
TW201336527A (en) 2012-02-10 2013-09-16 Alcon Res Ltd Aqueous pharmaceutical composition with enhanced stability
CN104271605B (en) 2012-02-15 2017-07-25 锡德克斯药物公司 The manufacture method of cyclodextrine derivatives
RU2747757C2 (en) 2012-02-28 2021-05-13 Сидекс Фармасьютикалс, Инк. Compositions of alkylated cyclodextrin and methods of their preparation and application
AU2013229173B2 (en) 2012-03-06 2017-06-01 Pfizer Inc. Macrocyclic derivatives for the treatment of proliferative diseases
US9365566B2 (en) 2012-03-27 2016-06-14 Takeda Pharmaceutical Company Limited Cinnoline derivatives
CN104302673B (en) 2012-03-30 2017-09-22 赛博尔泰克股份公司 Anthocyanidin compound
WO2014011695A2 (en) 2012-07-09 2014-01-16 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors
UY34893A (en) 2012-07-10 2014-02-28 Takeda Pharmaceutical DERIVATIVES OF AZAINDOL
JP2015524444A (en) 2012-08-03 2015-08-24 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Cyclodextrins for the treatment of lysosomal storage diseases
US9475816B2 (en) 2012-09-07 2016-10-25 Takeda Pharmaceutical Company Limited Substituted-1,4-dihydropyrazolo[4,3-b]indoles
WO2014045029A1 (en) 2012-09-18 2014-03-27 Ziarco Pharma Ltd 2-(2-aminocyclohexyl)amino-pyrimidine-5-carboxamides as spleen tyrosine kinasei(syk) inhibitors
JP6254169B2 (en) 2012-09-28 2017-12-27 ファイザー・インク Benzamide and heterobenzamide compounds
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
JP2015531394A (en) 2012-10-04 2015-11-02 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ Pyrrolo [2,3-D] pyrimidine tropomyosin-related kinase inhibitor
EP2912036A1 (en) 2012-10-04 2015-09-02 Pfizer Limited Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
CA2885247A1 (en) 2012-10-04 2014-04-10 Pfizer Limited Tropomyosin-related kinase inhibitors
US20150258202A1 (en) * 2012-10-17 2015-09-17 Sapiotec Gmbh Anthocyanidin complex for the treatment of multiple myeloma
MY181829A (en) 2012-10-22 2021-01-08 Cydex Pharmaceuticals Inc Alkylated cyclodextrin compositions and processes for preparing and using the same
AU2013343105B2 (en) 2012-11-08 2016-04-14 Pfizer Inc. Heteroaromatic compounds as dopamine D1 ligands
CN104981472A (en) 2012-11-08 2015-10-14 辉瑞大药厂 Heteroaromatic compounds and their use as dopamine d1 ligands
DK2919791T3 (en) * 2012-11-15 2017-07-17 Sapiotec Gmbh Delphinidine complex as antiflogistic or immunosuppressant active substance
CA2890861C (en) 2012-11-21 2021-03-30 Raqualia Pharma Inc. Polymorphic forms of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2h-pyran-4-carboxylic acid
EP2925725B1 (en) 2012-12-03 2016-11-09 Pfizer Inc. Novel selective androgen receptor modulators
CA2893881C (en) * 2012-12-11 2020-09-22 Sapiotec Gmbh Delphinidin for combating melanoma cells
UA112028C2 (en) 2012-12-14 2016-07-11 Пфайзер Лімітед IMIDAZOPYRIDASINE DERIVATIVES AS HAMBA-RECEPTOR MODULATORS
UA111305C2 (en) 2012-12-21 2016-04-11 Пфайзер Інк. Condensed with lactams of aryl and heteroaryl
CA2898631C (en) 2013-01-23 2023-06-13 Aldeyra Therapeutics, Inc. Toxic aldehyde related diseases and treatment
EP3431475B1 (en) 2013-02-21 2021-04-07 Pfizer Inc Solid forms of a selective cdk4/6 inhibitor
JO3377B1 (en) 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co Pyridinyl and fused pyridinyl triazolone derivatives
PL2968369T3 (en) 2013-03-13 2019-03-29 Sage Therapeutics, Inc. Neuroactive steroids and methods of use thereof
EP2970504A4 (en) 2013-03-13 2017-01-18 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
EP2784083A1 (en) 2013-03-28 2014-10-01 Charité - Universitätsmedizin Berlin Bone Morphogenetic Protein (BMP) variants with highly reduced antagonist sensitivity and enhanced specific biological activity
PL2986623T3 (en) 2013-04-17 2019-04-30 Sage Therapeutics Inc 19-nor c3,3-disubstituted c21-n-pyrazolyl steroids and methods of use thereof
AU2014256228C1 (en) 2013-04-17 2017-09-14 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
TW201443025A (en) 2013-04-19 2014-11-16 Pfizer Ltd Chemical compounds
TW201512171A (en) 2013-04-19 2015-04-01 Pfizer Ltd Chemical compounds
WO2014181213A1 (en) 2013-05-10 2014-11-13 Pfizer Inc. Crystalline form of (sa)-(-)-3-(3-bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1 (2h)-yl)-n,4-dimethylbenzamide
MA38661A1 (en) 2013-06-27 2017-03-31 Pfizer Heteroaromatic compounds and their use as d1 dopamine ligands
US9364458B2 (en) 2013-07-08 2016-06-14 Abbvie Inc. Stabilized pharmaceutical dosage forms comprising atrasentan
GB201312737D0 (en) 2013-07-17 2013-08-28 Univ Greenwich Cyclodextrin
EP3868382A1 (en) 2013-07-19 2021-08-25 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
PT3488852T (en) 2013-08-23 2021-02-03 Sage Therapeutics Inc Neuroactive steroids, compositions, and uses thereof
US8962675B1 (en) 2013-09-12 2015-02-24 Abbvie Inc. Atrasentan mandelate salts
CN104513253A (en) 2013-10-01 2015-04-15 南京波尔泰药业科技有限公司 Macrocyclic compounds for the treatment of proliferative diseases
RU2572334C2 (en) * 2013-12-06 2016-01-10 Общество С Ограниченной Ответственностью "Луфатен" Clathrate complex of arabinogalactan or arabic gum with 20-hydroxyecdysones, method for producing it (versions), pharmaceutical composition and medicinal product
CA2934010A1 (en) 2013-12-20 2015-06-25 Pfizer Limited N-acylpiperidine ether tropomyosin-related kinase inhibitors
UY35945A (en) 2014-01-09 2015-08-31 Takeda Pharmaceutical DERIVATIVES OF AZAINDOL
WO2015106014A1 (en) 2014-01-09 2015-07-16 Takeda Pharmaceutical Company Limited Azaindole derivatives
CN104971355B (en) * 2014-04-02 2018-04-24 上海现代药物制剂工程研究中心有限公司 Composition containing razaxaban and preparation method thereof
WO2015159175A1 (en) 2014-04-15 2015-10-22 Pfizer Inc. Tropomyosin-related kinase inhibitors containing both a 1h-pyrazole and a pyrimidine moiety
TN2016000452A1 (en) 2014-04-25 2018-04-04 Pfizer Heteroaromatic compounds and their use as dopamine d1 ligands.
US9868744B2 (en) 2014-04-25 2018-01-16 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands
EP3134404A1 (en) 2014-04-25 2017-03-01 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
JP6564394B2 (en) 2014-04-28 2019-08-21 ファイザー・インク Heterocyclic compounds and their use as dopamine D1 ligands
EP3137454A1 (en) 2014-04-28 2017-03-08 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
EP3140298A1 (en) 2014-05-07 2017-03-15 Pfizer Inc. Tropomyosin-related kinase inhibitors
GEP20186921B (en) 2014-05-14 2018-11-12 Pfizer Pyrazolopyridines and pyrazolopyrimidines
HUE052692T2 (en) 2014-05-15 2021-05-28 Pfizer Crystalline form of 6-[(4r)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile
KR102471082B1 (en) 2014-05-20 2022-11-25 라퀄리아 파마 인코포레이티드 Benzisoxazole derivative salt
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409485D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409488D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
SI3705488T1 (en) 2014-05-29 2022-10-28 Sage Therapeutics, Inc. Neuroactive steroids, compositions and uses thereof
EP3148992A1 (en) 2014-05-30 2017-04-05 Pfizer Inc. Benzenesulfonamides useful as sodium channel inhibitors
CA2950390C (en) 2014-05-30 2020-09-22 Pfizer Inc. Carbonitrile derivatives as selective androgen receptor modulators
ES2664810T3 (en) 2014-06-12 2018-04-23 Pfizer Limited Imidazopyridazine derivatives as modulators of GABAA receptor activity
WO2015193768A1 (en) 2014-06-17 2015-12-23 Pfizer Inc. Aryl fused lactams as ezh2 modulators
LT3157915T (en) 2014-06-17 2019-04-25 Pfizer Inc. Substituted dihydroisoquinolinone compounds
EP3157528B1 (en) 2014-06-18 2023-09-13 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
WO2015195448A1 (en) 2014-06-18 2015-12-23 Eli Lilly And Company Transdermal formulations of pergolide and uses thereof
WO2016009296A1 (en) 2014-07-16 2016-01-21 Pfizer Inc. N-acylpiperidine ether tropomyosin-related kinase inhibitors
WO2016009303A1 (en) 2014-07-17 2016-01-21 Pfizer Inc. Pharmaceutical combinations comprising gabapentin or pregabalin with nav1.7 inhibitors
WO2016009297A1 (en) 2014-07-18 2016-01-21 Pfizer Inc. Pyridine derivatives as muscarinic m1 receptor positive allosteric modulators
WO2016020784A1 (en) 2014-08-05 2016-02-11 Pfizer Inc. N-acylpyrrolidine ether tropomyosin-related kinase inhibitors
JP6914188B2 (en) * 2014-08-22 2021-08-04 サイデックス・ファーマシューティカルズ・インコーポレイテッド Fractional Alkylated Cyclodextrin Composition and Method for Preparation and Use thereof
WO2016034971A1 (en) 2014-09-04 2016-03-10 Pfizer Limited Sulfonamides derivatives as urat1 inhibitors
JOP20200195A1 (en) 2014-09-08 2017-06-16 Sage Therapeutics Inc Neuroactive steroids, compositions, and uses thereof
WO2016044433A2 (en) 2014-09-16 2016-03-24 Biopharma Works Metformin derivatives
GB201417163D0 (en) 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Substituted pyrimidine derivatives useful in the treatment of autoimmune diseases
GB201417165D0 (en) 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Treatments for Autoimmune Disease
PE20170907A1 (en) 2014-10-07 2017-07-12 Sage Therapeutics Inc NEUROACTIVE COMPOUNDS AND METHODS OF USING THEM
SG10202009859YA (en) 2014-10-16 2020-11-27 Sage Therapeutics Inc Compositions and methods for treating cns disorders
NZ769042A (en) 2014-10-16 2023-12-22 Sage Therapeutics Inc Compositions and methods for treating cns disorders
WO2016067143A1 (en) 2014-10-28 2016-05-06 Pfizer Inc. N-(2-alkyleneimino-3-phenylpropyl)acetamide compounds and their use against pain and pruritus via inhibition of trpa1 channels
LT3224269T (en) 2014-11-27 2020-07-10 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
ES2746839T3 (en) 2014-12-18 2020-03-09 Pfizer Pyrimidine and triazine derivatives and their use as AXL inhibitors
TW201636342A (en) 2014-12-19 2016-10-16 武田藥品工業有限公司 Fumagillol derivatives
JP6342587B2 (en) 2015-01-22 2018-06-13 フィトプラント リサーチ エス．エル． Cannabinoid purification method, composition and kit
ES2764840T3 (en) 2015-01-28 2020-06-04 Univ Bordeaux Use of plerixafor to treat and / or prevent acute exacerbations of chronic obstructive pulmonary disease
CN116139125A (en) 2015-02-02 2023-05-23 梅制药公司 Combination therapy
US20160228454A1 (en) 2015-02-06 2016-08-11 Marinus Pharmaceuticals, Inc. Intravenous ganaxolone formulations and methods of use in treating status epilepticus and other seizure disorders
ES2935476T3 (en) 2015-02-20 2023-03-07 Sage Therapeutics Inc Neuroactive steroids, compositions and uses thereof
CN107278205A (en) 2015-02-24 2017-10-20 辉瑞大药厂 Substituted nucleoside derivates as anticarcinogen
JP6676650B2 (en) 2015-03-13 2020-04-08 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． Conjugates for treating diseases
MX2017011966A (en) 2015-03-19 2018-06-06 Cydex Pharmaceuticals Inc Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same.
WO2016164763A1 (en) 2015-04-10 2016-10-13 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
BR112017026287A2 (en) 2015-06-10 2018-09-18 Vtesse Inc hydroxypropyl beta-cyclodextrin compositions and methods
EP3319610A4 (en) 2015-07-06 2019-03-06 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
IL305404A (en) 2015-07-06 2023-10-01 Sage Therapeutics Inc Oxysterols and methods of use thereof
RS62220B1 (en) 2015-07-06 2021-09-30 Sage Therapeutics Inc Oxysterols and methods of use thereof
US20170007617A1 (en) 2015-07-09 2017-01-12 Gilead Sciences Drive Intravenous formulations of a late sodium current inhibitor
CN107849017B (en) 2015-07-31 2021-03-30 辉瑞公司 1,1, 1-trifluoro-3-hydroxypropan-2-ylcarbamate derivatives and 1,1, 1-trifluoro-4-hydroxybutyl-2-ylcarbamate derivatives as MAGL inhibitors
WO2017035077A1 (en) 2015-08-21 2017-03-02 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
JP2018536677A (en) 2015-12-10 2018-12-13 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 4- (Bifen-3-yl) -1H-pyrazolo [3,4-c] pyridazine derivatives of formula (I) as GABA receptor modulators for use in the treatment of epilepsy and pain
ES2877089T3 (en) 2015-12-24 2021-11-16 Takeda Pharmaceuticals Co Co-crystal, method of production thereof, and medicine containing said co-crystal
TWI726968B (en) 2016-01-07 2021-05-11 開曼群島商Ｃｓ醫藥技術公司 Selective inhibitors of clinically important mutants of the egfr tyrosine kinase
WO2017119732A1 (en) 2016-01-08 2017-07-13 Samsung Electronics Co., Ltd. Electronic device and operating method thereof
AU2017208119B2 (en) 2016-01-15 2019-11-07 Pfizer Inc. 6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine dopamine D3 ligands
MX2018009948A (en) 2016-02-18 2018-12-06 Melinta Therapeutics Inc Oritavancin formulations.
CN109069530A (en) 2016-02-28 2018-12-21 奥尔德拉医疗公司 Allergic eye symptom is treated with cyclodextrin
EP3426772A4 (en) 2016-03-09 2019-08-28 Beijing Percans Oncology Co. Ltd. Tumor cell suspension cultures and related methods
JP7305352B2 (en) * 2016-03-31 2023-07-10 武田薬品工業株式会社 isoquinolinyltriazolone complex
JP7112331B2 (en) 2016-04-01 2022-08-03 セージ セラピューティクス， インコーポレイテッド Oxysterols and their uses
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
EP3454858A4 (en) 2016-05-09 2020-01-15 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
US20190030170A1 (en) * 2016-05-10 2019-01-31 Vireo Health LLC Cannabinoid formulations with improved solubility
CA2969295A1 (en) 2016-06-06 2017-12-06 Pfizer Inc. Substituted carbonucleoside derivatives, and use thereof as a prmt5 inhibitor
DK3481846T3 (en) 2016-07-07 2021-08-16 Sage Therapeutics Inc 11-SUBSTITUTED 24-HYDROXYSTEROLS FOR USE IN THE TREATMENT OF NMDA-RELATED CONDITIONS
CA3030413A1 (en) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C17, c20, and c21 substituted neuroactive steroids and their methods of use
EP3481844B1 (en) 2016-07-11 2024-04-17 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
SG11201811412XA (en) 2016-07-29 2019-02-27 Pfizer Cyclic peptides as c5 a receptor antagonists
US20180042903A1 (en) 2016-08-11 2018-02-15 Ovid Therapeutics Inc. Methods and compositions for treatment of epileptic disorders
MX2019001849A (en) 2016-08-15 2019-05-09 Pfizer Pyridopyrimdinone cdk2/4/6 inhibitors.
US10391105B2 (en) 2016-09-09 2019-08-27 Marinus Pharmaceuticals Inc. Methods of treating certain depressive disorders and delirium tremens
EP3519422B1 (en) 2016-09-30 2022-08-31 Sage Therapeutics, Inc. C7 substituted oxysterols and these compounds for use as nmda modulators
WO2018068832A1 (en) 2016-10-11 2018-04-19 Euro-Celtique S.A. Hodgkin lymphoma therapy
DK3529257T3 (en) 2016-10-18 2023-08-07 Sage Therapeutics Inc OXYSTEROLS AND METHODS OF USING THEREOF
KR102521573B1 (en) 2016-10-18 2023-04-14 세이지 테라퓨틱스, 인크. Oxysterols and methods of their use
CA3043979A1 (en) 2016-11-18 2018-05-24 Aicuris Anti-Infective Cures Gmbh Novel formulations of amidine substituted beta-lactam compounds on the basis of modified cyclodextrins and acidifying agents, their preparation and use as antimicrobial pharmaceutical compositions
US10316021B2 (en) 2016-11-28 2019-06-11 Pfizer Inc. Heteroarylphenoxy benzamide kappa opioid ligands
US11472776B2 (en) 2016-12-20 2022-10-18 Oligomerix, Inc. Quinazolinones that inhibit the formation of tau oligomers and their method of use
SG11201906417RA (en) 2017-01-20 2019-08-27 Pfizer 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives as magl inhibitors
JP6778833B2 (en) 2017-01-20 2020-11-04 深▲チェン▼市塔吉瑞生物医薬有限公司Ｓｈｅｎｚｈｅｎ ＴａｒｇｅｔＲｘ， Ｉｎｃ． (Hetero) arylamide compounds for suppressing kinase activity
WO2018133827A1 (en) 2017-01-20 2018-07-26 深圳市塔吉瑞生物医药有限公司 (hetero)arylamide compound for inhibiting protein kinase activity
RU2726631C1 (en) 2017-01-23 2020-07-15 Пфайзер Инк. Heterocyclic spiro compounds as magl inhibitors
WO2018146698A1 (en) 2017-02-07 2018-08-16 Biophore India Pharmaceuticals Pvt. Ltd. Improved method for the preparation of sulfobutylether beta cyclodextrin sodium
AU2018234919A1 (en) 2017-03-16 2019-09-19 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
DK3600312T3 (en) 2017-03-26 2023-07-31 Takeda Pharmaceuticals Co PIPERIDINYL AND PIPERAZINYL SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6
KR102444482B1 (en) 2017-04-01 2022-09-16 셍커 파마슈티컬스 (지앙수) 엘티디. 1H-imidazo[4,5-H]quinazoline compounds as protein kinase inhibitors
US20180318249A1 (en) 2017-05-03 2018-11-08 Cydex Pharmaceuticals, Inc. Composition containing cyclodextrin and busulfan
GB201709405D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating ovarian cancer
GB201709402D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating t-pll
GB201709403D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating sarcoma
GB201709406D0 (en) 2017-06-13 2017-07-26 Euro-Cletique S A Compounds for treating TNBC
JOP20180057A1 (en) 2017-06-15 2019-01-30 Takeda Pharmaceuticals Co Tetrahydropyridopyrazine modulators of gpr6
MX2019015468A (en) 2017-06-22 2020-08-03 Curadev Pharma Ltd Small molecule modulators of human sting.
CN108623576B (en) 2017-06-26 2021-01-08 深圳市塔吉瑞生物医药有限公司 Indazole compound for inhibiting kinase activity and composition and application thereof
CN110759908B (en) 2017-06-26 2021-03-12 深圳市塔吉瑞生物医药有限公司 N-benzenesulfonyl benzamide compound for inhibiting Bcl-2 protein and composition and application thereof
EP3651734A1 (en) 2017-07-11 2020-05-20 Gilead Sciences, Inc. Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections
KR20200038286A (en) 2017-08-11 2020-04-10 셍커 파마슈티컬스 (지앙수) 엘티디. 1H-pyrazolo [4,3-H] quinazoline compounds acting as protein phosphatase inhibitors
EP3653622B1 (en) 2017-08-30 2022-12-28 Shenzhen TargetRx, Inc. Aminopyrimidine compound and composition comprising same and use thereof
TWI808092B (en) 2017-08-30 2023-07-11 中國大陸商北京軒義醫藥科技有限公司 Cyclic di-nucleotides as stimulator of interferon genes modulators
EP3680236A4 (en) 2017-09-05 2021-04-21 Bioardis LLC Aromatic derivative, preparation method for same, and medical applications thereof
CA3074304A1 (en) 2017-09-11 2019-03-14 Krouzon Pharmaceuticals, Inc. Octahydrocyclopenta[c]pyrrole allosteric inhibitors of shp2
TW201920108A (en) 2017-09-25 2019-06-01 日商武田藥品工業有限公司 N-(cyano-substituted benzyl or pyridinylmethyl)-3-hydroxypicolinamide derivatives
MX2020003425A (en) 2017-10-10 2020-07-29 Aldeyra Therapeutics Inc Treatment of inflammatory disorders.
US20210228596A1 (en) 2017-10-12 2021-07-29 Sage Therapeutics, Inc. Method of treating cns disorders with neurosteroids and gabaergic compounds
KR20200096596A (en) 2017-12-08 2020-08-12 세이지 테라퓨틱스, 인크. Deuterated 21-[4-cyano-pyrazole-1-yl]-19-nor-pregan-3 for the treatment of CNS disorders. Alpha-ol-20-one derivative
WO2019120094A1 (en) 2017-12-21 2019-06-27 深圳市塔吉瑞生物医药有限公司 Arylphosphine oxides for inhibiting kinase activity
CN109627263B (en) 2017-12-21 2022-05-20 深圳市塔吉瑞生物医药有限公司 Diphenylaminopyrimidine compounds for inhibiting kinase activity
EP3730503A4 (en) 2017-12-21 2021-05-05 Shenzhen TargetRx, Inc. Antiviral nucleoside reverse transcriptase inhibitor
WO2019120071A1 (en) 2017-12-21 2019-06-27 深圳市塔吉瑞生物医药有限公司 Novel antiviral nucleoside reverse transcriptase inhibitor
JP2021506904A (en) 2017-12-22 2021-02-22 セージ セラピューティクス， インコーポレイテッド Compositions and Methods for the Treatment of CNS Disorders
IL310454A (en) 2017-12-22 2024-03-01 Sage Therapeutics Inc Compositions and methods for treating cns disorders
JP2021510695A (en) 2018-01-12 2021-04-30 セージ セラピューティクス， インコーポレイテッド Bruises, oxa, and thia-pregnane-20-on-3α-ol compounds for use in the treatment of CNS disorders
WO2019145552A1 (en) 2018-01-29 2019-08-01 Phytoplant Research S.L Methods of purifying cannabinoids using liquid:liquid chromatography
TW201942115A (en) 2018-02-01 2019-11-01 美商輝瑞股份有限公司 Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents
TW201942116A (en) 2018-02-09 2019-11-01 美商輝瑞股份有限公司 Tetrahydroquinazoline derivatives useful as anticancer agents
CN112236423B (en) 2018-03-01 2024-02-06 武田药品工业株式会社 Piperidinyl-3- (aryloxy) propanamides and propionic acid esters
TWI741268B (en) 2018-03-15 2021-10-01 美商輝瑞股份有限公司 Cyclopentane-based modulators of sting (stimulator of interferon genes)
WO2019201194A1 (en) 2018-04-16 2019-10-24 深圳市塔吉瑞生物医药有限公司 Substituted pyrrolotriazine compound, pharmaceutical composition thereof and use thereof
US11358973B2 (en) 2018-04-16 2022-06-14 Shenzhen Targetrx, Inc. Di(hetero)aryl macrocyclic compound for inhibiting protein kinase activity
MX2020011294A (en) 2018-04-26 2020-11-18 Pfizer 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors.
JP2021525809A (en) 2018-05-30 2021-09-27 コンバート ファーマシューティカルズ エス．エー． Prodrugs and their medical use
CA3101975A1 (en) 2018-06-01 2019-12-05 Bayer Cropscience Lp Stabilized fungicidal composition comprising cyclodextrin
WO2019243823A1 (en) 2018-06-21 2019-12-26 Curadev Pharma Limited Azaheterocyclic small molecule modulators of human sting
CN110194772B (en) 2018-07-02 2022-04-05 深圳市塔吉瑞生物医药有限公司 Alkynyl (hetero) aromatic ring compounds for inhibiting protein kinase activity
EP3816162A4 (en) 2018-07-12 2021-08-11 Shenzhen TargetRx, Inc. Diarylpyrazole compound, composition comprising same, and use thereof
CN110272426B (en) 2018-07-17 2022-05-31 深圳市塔吉瑞生物医药有限公司 Alkynyl (hetero) aromatic ring compounds for inhibiting protein kinase activity
US20210309669A1 (en) 2018-07-19 2021-10-07 Pfizer Inc. Heterocyclic Spiro Compounds As MAGL Inhibitors
WO2020033344A1 (en) 2018-08-06 2020-02-13 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
WO2020068986A1 (en) 2018-09-25 2020-04-02 Aldeyra Therapeutics, Inc. Formulations for treatment of dry eye disease
WO2020076728A1 (en) 2018-10-08 2020-04-16 Takeda Pharmaceutical Company Limited SUBSTITUTED OXAZINOPTERIDINONES AS INHIBITORS OF mTOR
WO2020073862A1 (en) 2018-10-10 2020-04-16 深圳市塔吉瑞生物医药有限公司 Dihydroimidazopyrazinone compound, composition including same, and use thereof
BR112021009428A2 (en) 2018-10-12 2021-08-31 Sage Therapeutics, Inc. NEUROACTIVE STEROIDS REPLACED AT POSITION 10 BY A CYCLIC GROUP FOR USE IN THE TREATMENT OF CNS DISORDERS
EP3867261A1 (en) 2018-10-19 2021-08-25 Sage Therapeutics, Inc. 9(11)-unsaturated neuroactive steroids and their methods of use
US11142525B2 (en) 2018-11-15 2021-10-12 Pfizer Inc. Azalactam compounds as HPK1 inhibitors
JP2022510628A (en) 2018-11-29 2022-01-27 ファイザー・インク Pyrazole as a regulator of hemoglobin
CN113383004A (en) 2018-12-05 2021-09-10 萨奇治疗股份有限公司 Neuroactive steroids and methods of use thereof
US20220017539A1 (en) 2018-12-06 2022-01-20 Shenzhen Targetrx, Inc. Substituted pyrazolo[1,5-a]pyridine compound, composition containing the same and use thereof
WO2020118142A1 (en) 2018-12-07 2020-06-11 Marinus Pharmaceuticals, Inc. Ganaxolone for use in prophylaxis and treatment of pospartum depression
WO2020125391A1 (en) 2018-12-21 2020-06-25 深圳市塔吉瑞生物医药有限公司 Aminopyrimidine compound used for inhibiting activity of protein kinase
EP3898646A1 (en) 2018-12-21 2021-10-27 Sage Therapeutics, Inc. 3.alpha.-hydroxy-17.beta.-amide neuroactive steroids and compositions thereof
WO2020141224A1 (en) 2019-01-04 2020-07-09 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
EP3911331A4 (en) 2019-01-14 2023-01-18 Beijing Xuanyi Pharmasciences Co., Ltd. Tetrazolone substituted steroids and use thereof
TWI732431B (en) 2019-01-23 2021-07-01 美商輝瑞股份有限公司 Polymorph
AU2020213761C1 (en) 2019-01-31 2023-08-10 Pfizer Inc. 3-carbonylamino-5-cyclopentyl-1 Fi-pyrazole compounds having inhibitory activity on CDK2
JP7323218B2 (en) 2019-02-18 2023-08-08 深▲チェン▼市塔吉瑞生物医薬有限公司 Substituted Fused Aromatic Ring Derivatives, Compositions Thereof, and Uses Thereof
WO2020173457A1 (en) 2019-02-27 2020-09-03 深圳市塔吉瑞生物医药有限公司 Substituted pyrazole compounds, compositions containing same, and use thereof
TW202102498A (en) 2019-03-22 2021-01-16 日商武田藥品工業股份有限公司 Pyridine-fused imidazole and pyrrole derivatives as ripk2 inhibitors
WO2020198064A1 (en) 2019-03-26 2020-10-01 Aldeyra Therapeutics, Inc. Ophthalmic formulations and uses thereof
EP3946606A1 (en) 2019-03-27 2022-02-09 Insilico Medicine IP Limited Bicyclic jak inhibitors and uses thereof
CN114072393A (en) 2019-04-29 2022-02-18 索伦特治疗有限责任公司 3-amino-4H-benzo [ E ] [1,2,4] thiadiazine 1, 1-dioxide derivatives as MRGX2 inhibitors
WO2020243488A1 (en) 2019-05-31 2020-12-03 Sage Therapeutics, Inc. Neuroactive steroids and compositions thereof
CN112047938B (en) 2019-06-06 2022-11-22 北京泰德制药股份有限公司 2,4, 6-trisubstituted pyrimidine compounds as ATR kinase inhibitors
CA3144701A1 (en) 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2020264512A1 (en) 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compounds for treating cns disorders
EP3990469A1 (en) 2019-06-27 2022-05-04 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
US11339159B2 (en) 2019-07-17 2022-05-24 Pfizer Inc. Toll-like receptor agonists
EP4003961A2 (en) 2019-07-25 2022-06-01 Curadev Pharma Pvt. Ltd. Small molecule inhibitors of acetyl coenzyme a synthetase short chain 2 (acss2)
CA3145923A1 (en) 2019-08-05 2021-02-11 David Czekai Ganaxolone for use in treatment of status epilepticus
US20230000997A1 (en) 2019-08-06 2023-01-05 L.E.A.F. Holdings Group Llc Processes of preparing polyglutamated antifolates and uses of their compositions
US20220306659A1 (en) 2019-08-23 2022-09-29 Beijing Tide Pharmaceutical Co., Ltd. Compound inhibiting and inducing degradation of egfr and alk
WO2021055326A1 (en) 2019-09-16 2021-03-25 Takeda Pharmaceutical Company Limited Azole-fused pyridazin-3(2h)-one derivatives
CA3155569A1 (en) 2019-09-25 2021-04-01 Pfizer Inc. Polyheterocyclic modulators of sting (stimulator of interferon genes)
WO2021057877A1 (en) 2019-09-26 2021-04-01 深圳市塔吉瑞生物医药有限公司 Substituted aromatic fused ring derivative and composition comprising same, and use thereof
JP2023502889A (en) 2019-11-01 2023-01-26 上海科技大学 EED INHIBITOR, METHOD OF MANUFACTURE THEREOF AND USE THEREOF
MX2022006014A (en) 2019-12-06 2022-06-22 Marinus Pharmaceuticals Inc Ganaxolone for use in treating tuberous sclerosis complex.
WO2021121261A1 (en) 2019-12-16 2021-06-24 北京泰德制药股份有限公司 Compound for inhibiting and inducing degradation of egfr kinase
US20230122967A1 (en) 2020-01-17 2023-04-20 Shengke Pharmaceuticals (Jiangsu) Ltd. Novel compounds as inhibitors of pcsk9
KR20220141328A (en) 2020-02-12 2022-10-19 큐라데브 파마 프라이버트 리미티드 Small molecule STING antagonists
CN115551874A (en) 2020-03-18 2022-12-30 萨奇治疗股份有限公司 Neuroactive steroids and methods of use thereof
AR121682A1 (en) 2020-03-31 2022-06-29 Takeda Pharmaceuticals Co N-(HETEROCYCLIL AND HETEROCYCLILALKYL)-3-BENZYLPYRIDIN-2-AMINE DERIVATIVES AS SSTR4 AGONISTS
AR121683A1 (en) 2020-03-31 2022-06-29 Takeda Pharmaceuticals Co N-HETEROARYLALKYL-2-(HETEROCYCLIL AND HETEROCYCLILMETHYL)ACETAMIDE DERIVATIVES AS SSTR4 AGONISTS
JP2021167301A (en) 2020-04-08 2021-10-21 ファイザー・インク Co-treatment with cdk4/6 and cdk2 inhibitors to suppress tumor adaptation to cdk2 inhibitors
CN115698004A (en) 2020-05-01 2023-02-03 辉瑞公司 Azalactam compounds as HPK1 inhibitors
WO2021225968A1 (en) 2020-05-04 2021-11-11 Takeda Pharmaceutical Company Limited Luminally-acting n-(piperidin-4-yl)benzamide derivatives
WO2021224818A1 (en) 2020-05-08 2021-11-11 Pfizer Inc. Isoindolone compounds as hpk1 inhibitors
KR20230012584A (en) 2020-05-20 2023-01-26 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 2,4,6-trisubstituted pyrimidine compounds as ATR kinase inhibitors
US20230250129A1 (en) 2020-06-24 2023-08-10 Sage Therapeutics, Inc. Neuroactive steroids and compositions thereof
TW202214641A (en) 2020-06-30 2022-04-16 美商艾瑞生藥股份有限公司 Her2 mutation inhibitors
BR112023000654A2 (en) 2020-07-13 2023-04-25 Beijing Tide Pharmaceutical Co Ltd PYRAZOLOPYRMIDINE COMPOUND USED AS AN ATR KINASE INHIBTOR
WO2022013692A1 (en) 2020-07-15 2022-01-20 Pfizer Inc. Polymorphs of (1s,2s,3s,5r)-3-((6-(difluoromethyl)-5-flu­oro-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy)-5-(4-methyl-7h-pyrrolo[2,3-d]­pyrimidin-7-yl)cyclopentane-1,2-diol mono-hydrochloride
WO2022013691A1 (en) 2020-07-15 2022-01-20 Pfizer Inc. Polymorph of (1s,2s,3s,5r)-3-((6-(difluoromethyl)-5-flu­oro-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy)-5-(4-methyl-7h-pyrrolo[2,3-d]­pyrimidin-7-yl)cyclopentane-1,2-diol
WO2022018667A1 (en) 2020-07-24 2022-01-27 Pfizer Inc. Combination therapies using cdk2 and cdc25a inhibitors
GB202011812D0 (en) 2020-07-29 2020-09-09 Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid Compounds
GB202011811D0 (en) 2020-07-29 2020-09-09 Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid Compounds
JP2023538774A (en) 2020-08-27 2023-09-11 晟科薬業（江蘇）有限公司 1H-imidazo[4,5-H]quinazoline compounds as novel selective FLT3 inhibitors
TW202229239A (en) 2020-09-23 2022-08-01 日商武田藥品工業股份有限公司 3-(6-aminopyridin-3-yl)benzamide derivatives as ripk2 inhibitors
JP2023550653A (en) 2020-11-25 2023-12-04 セージ セラピューティクス， インコーポレイテッド Compositions and methods for treating disorders of the CNS
IL306034A (en) 2021-03-18 2023-11-01 Pfizer Modulators of sting (stimulator of interferon genes)
CA3213593A1 (en) 2021-03-31 2022-10-06 Sevenless Therapeutics Limited Sos1 inhibitors and ras inhibitors for use in the treatment of pain
GB202104609D0 (en) 2021-03-31 2021-05-12 Sevenless Therapeutics Ltd New Treatments for Pain
CN117545751A (en) 2021-04-07 2024-02-09 生命爱科 2, 4-diaminopyrimidine derivatives as ULK1/2 inhibitors and their use
US11649299B2 (en) 2021-06-10 2023-05-16 Cyclolab Cyclodextrin Research And Development Laboratory Ltd. Purification of sulfobutylated cyclodextrins with specific ion exchange resins
CA3225045A1 (en) 2021-06-26 2022-12-29 Array Biopharma Inc. Her2 mutation inhibitors
CN117693516A (en) 2021-07-28 2024-03-12 萨奇治疗股份有限公司 Crystalline forms of neuroactive steroid
AU2022326885A1 (en) 2021-08-11 2024-02-15 Curadev Pharma Pvt. Ltd. Small molecule urea derivatives as sting antagonists
CA3228528A1 (en) 2021-08-11 2023-02-16 Monali BANERJEE Small molecule sting antagonists
WO2023049295A1 (en) 2021-09-22 2023-03-30 Sage Therapeutics, Inc. Deuterated positive nmda-modulating compounds and methods of use thereof
WO2023099072A1 (en) 2021-12-01 2023-06-08 Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Compounds
WO2023144692A1 (en) * 2022-01-25 2023-08-03 Leiutis Pharmaceuticals Llp Novel naproxen sodium preparations for parenteral
WO2023156966A1 (en) 2022-02-18 2023-08-24 Beren Therapeutics P.B.C. Compositions of hydroxypropyl-beta-cyclodextrin and methods of purifying the same
WO2023187677A1 (en) 2022-03-30 2023-10-05 Takeda Pharmaceutical Company Limited N-(pyrrolidin-3-yl or piperidin-4-yl)acetamide derivatives
TW202345838A (en) 2022-04-07 2023-12-01 日商武田藥品工業股份有限公司 Fused pyridazine derivatives
WO2023205165A1 (en) * 2022-04-22 2023-10-26 Brii Biosciences Offshore Limited A polymyxin composition and methods for producing the same
EP4332087A1 (en) 2022-04-29 2024-03-06 Beijing Jitai Pharmaceutical Technology Co., Ltd. Lipid nanoparticles
CN116969851A (en) 2022-04-29 2023-10-31 北京剂泰医药科技有限公司 Ionizable lipid compounds
WO2024026337A1 (en) 2022-07-27 2024-02-01 Sage Therapeutics, Inc. Crystalline forms of a neuroactive steroid
US20240109915A1 (en) 2022-07-29 2024-04-04 Pfizer Inc. Novel acc inhibitors
WO2024033845A1 (en) 2022-08-10 2024-02-15 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2024059608A1 (en) 2022-09-15 2024-03-21 Sage Therapeutics, Inc. Deuterated neuroactive steroids
WO2024074827A1 (en) 2022-10-05 2024-04-11 Sevenless Therapeutics Limited New treatments for pain

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3426011A (en) * 1967-02-13 1969-02-04 Corn Products Co Cyclodextrins with anionic properties
JPS503362B1 (en) * 1970-06-10 1975-02-04
CA1222742A (en) * 1981-01-23 1987-06-09 Harry P. Jones INCLUSION COMPLEX OF .beta.-CYCLODEXTRIN AND DIGOXIN
JPS58177949A (en) * 1982-04-12 1983-10-18 Takeda Chem Ind Ltd Clathrate compound of lankacidin-group antibiotic substance
HU191101B (en) * 1983-02-14 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for preparing water-soluble cyclodextrin polymers substituted with ionic groups
EP0146841A3 (en) * 1983-12-17 1986-11-20 Consortium für elektrochemische Industrie GmbH Water soluble mixed ether of beta-cyclodextrin, and process for its preparation
EP0147685B1 (en) * 1983-12-17 1989-04-26 Hoechst Aktiengesellschaft Beta-cyclodextrin and process for its preparation
US4596795A (en) * 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
JPH0651725B2 (en) * 1985-02-28 1994-07-06 メルシャン株式会社 Partially methylated cyclodextrin and method for producing the same
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
US4808232A (en) * 1986-12-08 1989-02-28 American Maize-Products Company Separation and purification of cyclodextrins
JPH0819004B2 (en) * 1986-12-26 1996-02-28 日清製粉株式会社 Sustained-release pharmaceutical preparation
US4774329A (en) * 1987-08-04 1988-09-27 American Maize-Products Company Controlled release agent for cetylpyridinium chloride
KR0166088B1 (en) * 1990-01-23 1999-01-15 . Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
WO1991013100A1 (en) * 1990-03-02 1991-09-05 Australian Commercial Research & Development Limited Cyclodextrin compositions and methods for pharmaceutical and industrial applications

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