CA2111199A1 - Pharmaceutical formulations of osteogenic proteins - Google Patents

Pharmaceutical formulations of osteogenic proteins

Info

Publication number
CA2111199A1
CA2111199A1 CA002111199A CA2111199A CA2111199A1 CA 2111199 A1 CA2111199 A1 CA 2111199A1 CA 002111199 A CA002111199 A CA 002111199A CA 2111199 A CA2111199 A CA 2111199A CA 2111199 A1 CA2111199 A1 CA 2111199A1
Authority
CA
Canada
Prior art keywords
pharmaceutical formulations
osteogenic proteins
poly
osteogenic protein
lactic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002111199A
Other languages
French (fr)
Other versions
CA2111199C (en
Inventor
Eyal Ron
Thomas J. Turek
Benjamin S. Isaacs
Himakshi Patel
Richard A. Kenley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Eyal Ron
Thomas J. Turek
Benjamin S. Isaacs
Himakshi Patel
Richard A. Kenley
Genetics Institute, Inc.
Genetics Institute, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eyal Ron, Thomas J. Turek, Benjamin S. Isaacs, Himakshi Patel, Richard A. Kenley, Genetics Institute, Inc., Genetics Institute, Llc filed Critical Eyal Ron
Publication of CA2111199A1 publication Critical patent/CA2111199A1/en
Application granted granted Critical
Publication of CA2111199C publication Critical patent/CA2111199C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones

Abstract

A composition comprising a pharmaceutically acceptable admixture of an osteogenic protein; a polymer matrix compo-nent selected from the group consisting of poly(lactic acid), poly(glycolic acid), and copolymers of lactic acid and glycolic acid;
and an osteogenic protein-sequestering material.
CA002111199A 1991-06-21 1992-06-22 Pharmaceutical formulations of osteogenic proteins Expired - Fee Related CA2111199C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71872191A 1991-06-21 1991-06-21
US07/718,721 1991-06-21
PCT/US1992/005309 WO1993000050A1 (en) 1991-06-21 1992-06-22 Pharmaceutical formulations of osteogenic proteins

Publications (2)

Publication Number Publication Date
CA2111199A1 true CA2111199A1 (en) 1993-01-07
CA2111199C CA2111199C (en) 2008-08-05

Family

ID=24887221

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002111199A Expired - Fee Related CA2111199C (en) 1991-06-21 1992-06-22 Pharmaceutical formulations of osteogenic proteins

Country Status (15)

Country Link
US (1) US5597897A (en)
EP (1) EP0591392B1 (en)
JP (1) JP3351525B2 (en)
KR (1) KR0145278B1 (en)
AT (1) ATE142460T1 (en)
AU (1) AU663328B2 (en)
CA (1) CA2111199C (en)
DE (1) DE69213739T2 (en)
DK (1) DK0591392T3 (en)
ES (1) ES2094359T3 (en)
FI (1) FI109274B (en)
GR (1) GR3021627T3 (en)
MX (1) MX9203083A (en)
NO (2) NO934573D0 (en)
WO (1) WO1993000050A1 (en)

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CA2111199C (en) 2008-08-05
FI935732A (en) 1993-12-20
AU663328B2 (en) 1995-10-05
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KR0145278B1 (en) 1998-07-15
FI109274B (en) 2002-06-28
DE69213739D1 (en) 1996-10-17
AU2254292A (en) 1993-01-25
WO1993000050A1 (en) 1993-01-07
FI935732A0 (en) 1993-12-20
JPH06508777A (en) 1994-10-06
GR3021627T3 (en) 1997-02-28
US5597897A (en) 1997-01-28
ATE142460T1 (en) 1996-09-15
DE69213739T2 (en) 1997-02-20
DK0591392T3 (en) 1996-09-30
ES2094359T3 (en) 1997-01-16
EP0591392B1 (en) 1996-09-11
NO307402B1 (en) 2000-04-03
JP3351525B2 (en) 2002-11-25
EP0591392A1 (en) 1994-04-13
MX9203083A (en) 1994-08-31

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